-- dump date 20140618_214321 -- class Genbank::misc_feature -- table misc_feature_note -- id note 222523000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 222523000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 222523000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523000004 Walker A motif; other site 222523000005 ATP binding site [chemical binding]; other site 222523000006 Walker B motif; other site 222523000007 arginine finger; other site 222523000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 222523000009 DnaA box-binding interface [nucleotide binding]; other site 222523000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 222523000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 222523000012 putative DNA binding surface [nucleotide binding]; other site 222523000013 dimer interface [polypeptide binding]; other site 222523000014 beta-clamp/clamp loader binding surface; other site 222523000015 beta-clamp/translesion DNA polymerase binding surface; other site 222523000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 222523000017 recombination protein F; Reviewed; Region: recF; PRK00064 222523000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 222523000019 Walker A/P-loop; other site 222523000020 ATP binding site [chemical binding]; other site 222523000021 Q-loop/lid; other site 222523000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523000023 ABC transporter signature motif; other site 222523000024 Walker B; other site 222523000025 D-loop; other site 222523000026 H-loop/switch region; other site 222523000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 222523000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523000029 Mg2+ binding site [ion binding]; other site 222523000030 G-X-G motif; other site 222523000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 222523000032 anchoring element; other site 222523000033 dimer interface [polypeptide binding]; other site 222523000034 ATP binding site [chemical binding]; other site 222523000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 222523000036 active site 222523000037 putative metal-binding site [ion binding]; other site 222523000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 222523000039 DNA gyrase subunit A; Validated; Region: PRK05560 222523000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 222523000041 CAP-like domain; other site 222523000042 active site 222523000043 primary dimer interface [polypeptide binding]; other site 222523000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523000050 YaaC-like Protein; Region: YaaC; pfam14175 222523000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 222523000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 222523000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 222523000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 222523000055 active site 222523000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 222523000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 222523000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 222523000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 222523000061 active site 222523000062 multimer interface [polypeptide binding]; other site 222523000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 222523000064 predicted active site [active] 222523000065 catalytic triad [active] 222523000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 222523000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 222523000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 222523000069 dimer interface [polypeptide binding]; other site 222523000070 active site 222523000071 motif 1; other site 222523000072 motif 2; other site 222523000073 motif 3; other site 222523000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 222523000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523000076 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 222523000077 DNA binding residues [nucleotide binding] 222523000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 222523000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 222523000080 Substrate-binding site [chemical binding]; other site 222523000081 Substrate specificity [chemical binding]; other site 222523000082 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 222523000083 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 222523000084 Substrate-binding site [chemical binding]; other site 222523000085 Substrate specificity [chemical binding]; other site 222523000086 Isochorismatase family; Region: Isochorismatase; pfam00857 222523000087 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 222523000088 catalytic triad [active] 222523000089 conserved cis-peptide bond; other site 222523000090 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 222523000091 nucleoside/Zn binding site; other site 222523000092 dimer interface [polypeptide binding]; other site 222523000093 catalytic motif [active] 222523000094 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 222523000095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523000096 Walker A motif; other site 222523000097 ATP binding site [chemical binding]; other site 222523000098 Walker B motif; other site 222523000099 arginine finger; other site 222523000100 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 222523000101 hypothetical protein; Validated; Region: PRK00153 222523000102 recombination protein RecR; Reviewed; Region: recR; PRK00076 222523000103 RecR protein; Region: RecR; pfam02132 222523000104 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 222523000105 putative active site [active] 222523000106 putative metal-binding site [ion binding]; other site 222523000107 tetramer interface [polypeptide binding]; other site 222523000108 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 222523000109 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 222523000110 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 222523000111 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 222523000112 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 222523000113 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523000114 catalytic residue [active] 222523000115 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 222523000116 thymidylate kinase; Validated; Region: tmk; PRK00698 222523000117 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 222523000118 TMP-binding site; other site 222523000119 ATP-binding site [chemical binding]; other site 222523000120 DNA polymerase III subunit delta'; Validated; Region: PRK08058 222523000121 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 222523000122 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 222523000123 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 222523000124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523000125 S-adenosylmethionine binding site [chemical binding]; other site 222523000126 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 222523000127 GIY-YIG motif/motif A; other site 222523000128 putative active site [active] 222523000129 putative metal binding site [ion binding]; other site 222523000130 Predicted methyltransferases [General function prediction only]; Region: COG0313 222523000131 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 222523000132 putative SAM binding site [chemical binding]; other site 222523000133 putative homodimer interface [polypeptide binding]; other site 222523000134 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 222523000135 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 222523000136 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 222523000137 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 222523000138 active site 222523000139 HIGH motif; other site 222523000140 KMSKS motif; other site 222523000141 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 222523000142 tRNA binding surface [nucleotide binding]; other site 222523000143 anticodon binding site; other site 222523000144 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 222523000145 dimer interface [polypeptide binding]; other site 222523000146 putative tRNA-binding site [nucleotide binding]; other site 222523000147 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 222523000148 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 222523000149 active site 222523000150 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 222523000151 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 222523000152 putative active site [active] 222523000153 putative metal binding site [ion binding]; other site 222523000154 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 222523000155 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 222523000156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523000157 S-adenosylmethionine binding site [chemical binding]; other site 222523000158 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 222523000159 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 222523000160 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 222523000161 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 222523000162 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 222523000163 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 222523000164 pur operon repressor; Provisional; Region: PRK09213 222523000165 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 222523000166 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523000167 active site 222523000168 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 222523000169 homotrimer interaction site [polypeptide binding]; other site 222523000170 putative active site [active] 222523000171 regulatory protein SpoVG; Reviewed; Region: PRK13259 222523000172 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 222523000173 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 222523000174 Substrate binding site; other site 222523000175 Mg++ binding site; other site 222523000176 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 222523000177 active site 222523000178 substrate binding site [chemical binding]; other site 222523000179 CoA binding site [chemical binding]; other site 222523000180 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 222523000181 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 222523000182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523000183 active site 222523000184 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 222523000185 putative active site [active] 222523000186 catalytic residue [active] 222523000187 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 222523000188 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 222523000189 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 222523000190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523000191 ATP binding site [chemical binding]; other site 222523000192 putative Mg++ binding site [ion binding]; other site 222523000193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523000194 nucleotide binding region [chemical binding]; other site 222523000195 ATP-binding site [chemical binding]; other site 222523000196 TRCF domain; Region: TRCF; pfam03461 222523000197 stage V sporulation protein T; Region: spore_V_T; TIGR02851 222523000198 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 222523000199 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 222523000200 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 222523000201 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 222523000202 putative SAM binding site [chemical binding]; other site 222523000203 putative homodimer interface [polypeptide binding]; other site 222523000204 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 222523000205 homodimer interface [polypeptide binding]; other site 222523000206 metal binding site [ion binding]; metal-binding site 222523000207 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 222523000208 homodimer interface [polypeptide binding]; other site 222523000209 active site 222523000210 putative chemical substrate binding site [chemical binding]; other site 222523000211 metal binding site [ion binding]; metal-binding site 222523000212 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523000213 RNA binding surface [nucleotide binding]; other site 222523000214 sporulation protein YabP; Region: spore_yabP; TIGR02892 222523000215 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 222523000216 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 222523000217 Septum formation initiator; Region: DivIC; pfam04977 222523000218 hypothetical protein; Provisional; Region: PRK08582 222523000219 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 222523000220 RNA binding site [nucleotide binding]; other site 222523000221 stage II sporulation protein E; Region: spore_II_E; TIGR02865 222523000222 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 222523000223 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 222523000224 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 222523000225 Ligand Binding Site [chemical binding]; other site 222523000226 TilS substrate binding domain; Region: TilS; pfam09179 222523000227 TilS substrate C-terminal domain; Region: TilS_C; smart00977 222523000228 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523000229 active site 222523000230 FtsH Extracellular; Region: FtsH_ext; pfam06480 222523000231 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 222523000232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523000233 Walker A motif; other site 222523000234 ATP binding site [chemical binding]; other site 222523000235 Walker B motif; other site 222523000236 arginine finger; other site 222523000237 Peptidase family M41; Region: Peptidase_M41; pfam01434 222523000238 pantothenate kinase; Reviewed; Region: PRK13318 222523000239 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 222523000240 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 222523000241 dimerization interface [polypeptide binding]; other site 222523000242 domain crossover interface; other site 222523000243 redox-dependent activation switch; other site 222523000244 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 222523000245 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 222523000246 dimer interface [polypeptide binding]; other site 222523000247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523000248 catalytic residue [active] 222523000249 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 222523000250 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 222523000251 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 222523000252 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 222523000253 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 222523000254 glutamine binding [chemical binding]; other site 222523000255 catalytic triad [active] 222523000256 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 222523000257 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 222523000258 homodimer interface [polypeptide binding]; other site 222523000259 substrate-cofactor binding pocket; other site 222523000260 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523000261 catalytic residue [active] 222523000262 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 222523000263 dihydropteroate synthase; Region: DHPS; TIGR01496 222523000264 substrate binding pocket [chemical binding]; other site 222523000265 dimer interface [polypeptide binding]; other site 222523000266 inhibitor binding site; inhibition site 222523000267 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 222523000268 homooctamer interface [polypeptide binding]; other site 222523000269 active site 222523000270 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 222523000271 catalytic center binding site [active] 222523000272 ATP binding site [chemical binding]; other site 222523000273 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523000274 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523000275 non-specific DNA binding site [nucleotide binding]; other site 222523000276 salt bridge; other site 222523000277 sequence-specific DNA binding site [nucleotide binding]; other site 222523000278 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 222523000279 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 222523000280 FMN binding site [chemical binding]; other site 222523000281 active site 222523000282 catalytic residues [active] 222523000283 substrate binding site [chemical binding]; other site 222523000284 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 222523000285 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 222523000286 dimer interface [polypeptide binding]; other site 222523000287 putative anticodon binding site; other site 222523000288 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 222523000289 motif 1; other site 222523000290 active site 222523000291 motif 2; other site 222523000292 motif 3; other site 222523000293 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 222523000294 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 222523000295 UvrB/uvrC motif; Region: UVR; pfam02151 222523000296 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 222523000297 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 222523000298 ADP binding site [chemical binding]; other site 222523000299 phosphagen binding site; other site 222523000300 substrate specificity loop; other site 222523000301 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 222523000302 Clp amino terminal domain; Region: Clp_N; pfam02861 222523000303 Clp amino terminal domain; Region: Clp_N; pfam02861 222523000304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523000305 Walker A motif; other site 222523000306 ATP binding site [chemical binding]; other site 222523000307 Walker B motif; other site 222523000308 arginine finger; other site 222523000309 UvrB/uvrC motif; Region: UVR; pfam02151 222523000310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523000311 Walker A motif; other site 222523000312 ATP binding site [chemical binding]; other site 222523000313 Walker B motif; other site 222523000314 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 222523000315 DNA repair protein RadA; Provisional; Region: PRK11823 222523000316 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 222523000317 Walker A motif/ATP binding site; other site 222523000318 ATP binding site [chemical binding]; other site 222523000319 Walker B motif; other site 222523000320 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 222523000321 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 222523000322 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 222523000323 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 222523000324 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 222523000325 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 222523000326 putative active site [active] 222523000327 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 222523000328 substrate binding site; other site 222523000329 dimer interface; other site 222523000330 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 222523000331 homotrimer interaction site [polypeptide binding]; other site 222523000332 zinc binding site [ion binding]; other site 222523000333 CDP-binding sites; other site 222523000334 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 222523000335 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 222523000336 active site 222523000337 HIGH motif; other site 222523000338 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 222523000339 active site 222523000340 KMSKS motif; other site 222523000341 serine O-acetyltransferase; Region: cysE; TIGR01172 222523000342 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 222523000343 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 222523000344 trimer interface [polypeptide binding]; other site 222523000345 active site 222523000346 substrate binding site [chemical binding]; other site 222523000347 CoA binding site [chemical binding]; other site 222523000348 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 222523000349 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 222523000350 active site 222523000351 HIGH motif; other site 222523000352 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 222523000353 KMSKS motif; other site 222523000354 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 222523000355 tRNA binding surface [nucleotide binding]; other site 222523000356 anticodon binding site; other site 222523000357 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 222523000358 active site 222523000359 metal binding site [ion binding]; metal-binding site 222523000360 dimerization interface [polypeptide binding]; other site 222523000361 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 222523000362 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 222523000363 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 222523000364 YacP-like NYN domain; Region: NYN_YacP; pfam05991 222523000365 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 222523000366 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523000367 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 222523000368 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 222523000369 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 222523000370 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 222523000371 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 222523000372 putative homodimer interface [polypeptide binding]; other site 222523000373 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 222523000374 heterodimer interface [polypeptide binding]; other site 222523000375 homodimer interface [polypeptide binding]; other site 222523000376 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 222523000377 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 222523000378 23S rRNA interface [nucleotide binding]; other site 222523000379 L7/L12 interface [polypeptide binding]; other site 222523000380 putative thiostrepton binding site; other site 222523000381 L25 interface [polypeptide binding]; other site 222523000382 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 222523000383 mRNA/rRNA interface [nucleotide binding]; other site 222523000384 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 222523000385 23S rRNA interface [nucleotide binding]; other site 222523000386 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 222523000387 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 222523000388 core dimer interface [polypeptide binding]; other site 222523000389 peripheral dimer interface [polypeptide binding]; other site 222523000390 L10 interface [polypeptide binding]; other site 222523000391 L11 interface [polypeptide binding]; other site 222523000392 putative EF-Tu interaction site [polypeptide binding]; other site 222523000393 putative EF-G interaction site [polypeptide binding]; other site 222523000394 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 222523000395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523000396 S-adenosylmethionine binding site [chemical binding]; other site 222523000397 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 222523000398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 222523000399 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 222523000400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 222523000401 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 222523000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 222523000403 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 222523000404 RPB10 interaction site [polypeptide binding]; other site 222523000405 RPB1 interaction site [polypeptide binding]; other site 222523000406 RPB11 interaction site [polypeptide binding]; other site 222523000407 RPB3 interaction site [polypeptide binding]; other site 222523000408 RPB12 interaction site [polypeptide binding]; other site 222523000409 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 222523000410 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 222523000411 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 222523000412 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 222523000413 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 222523000414 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 222523000415 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 222523000416 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 222523000417 G-loop; other site 222523000418 DNA binding site [nucleotide binding] 222523000419 hypothetical protein; Provisional; Region: PRK06683 222523000420 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 222523000421 S17 interaction site [polypeptide binding]; other site 222523000422 S8 interaction site; other site 222523000423 16S rRNA interaction site [nucleotide binding]; other site 222523000424 streptomycin interaction site [chemical binding]; other site 222523000425 23S rRNA interaction site [nucleotide binding]; other site 222523000426 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 222523000427 30S ribosomal protein S7; Validated; Region: PRK05302 222523000428 elongation factor G; Reviewed; Region: PRK00007 222523000429 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 222523000430 G1 box; other site 222523000431 putative GEF interaction site [polypeptide binding]; other site 222523000432 GTP/Mg2+ binding site [chemical binding]; other site 222523000433 Switch I region; other site 222523000434 G2 box; other site 222523000435 G3 box; other site 222523000436 Switch II region; other site 222523000437 G4 box; other site 222523000438 G5 box; other site 222523000439 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 222523000440 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 222523000441 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 222523000442 elongation factor Tu; Reviewed; Region: PRK00049 222523000443 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 222523000444 G1 box; other site 222523000445 GEF interaction site [polypeptide binding]; other site 222523000446 GTP/Mg2+ binding site [chemical binding]; other site 222523000447 Switch I region; other site 222523000448 G2 box; other site 222523000449 G3 box; other site 222523000450 Switch II region; other site 222523000451 G4 box; other site 222523000452 G5 box; other site 222523000453 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 222523000454 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 222523000455 Antibiotic Binding Site [chemical binding]; other site 222523000456 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 222523000457 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 222523000458 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 222523000459 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 222523000460 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 222523000461 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 222523000462 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 222523000463 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 222523000464 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 222523000465 putative translocon binding site; other site 222523000466 protein-rRNA interface [nucleotide binding]; other site 222523000467 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 222523000468 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 222523000469 G-X-X-G motif; other site 222523000470 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 222523000471 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 222523000472 23S rRNA interface [nucleotide binding]; other site 222523000473 5S rRNA interface [nucleotide binding]; other site 222523000474 putative antibiotic binding site [chemical binding]; other site 222523000475 L25 interface [polypeptide binding]; other site 222523000476 L27 interface [polypeptide binding]; other site 222523000477 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 222523000478 23S rRNA interface [nucleotide binding]; other site 222523000479 putative translocon interaction site; other site 222523000480 signal recognition particle (SRP54) interaction site; other site 222523000481 L23 interface [polypeptide binding]; other site 222523000482 trigger factor interaction site; other site 222523000483 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 222523000484 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 222523000485 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 222523000486 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 222523000487 RNA binding site [nucleotide binding]; other site 222523000488 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 222523000489 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 222523000490 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 222523000491 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 222523000492 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 222523000493 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 222523000494 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 222523000495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 222523000496 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 222523000497 5S rRNA interface [nucleotide binding]; other site 222523000498 L27 interface [polypeptide binding]; other site 222523000499 23S rRNA interface [nucleotide binding]; other site 222523000500 L5 interface [polypeptide binding]; other site 222523000501 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 222523000502 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 222523000503 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 222523000504 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 222523000505 23S rRNA binding site [nucleotide binding]; other site 222523000506 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 222523000507 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 222523000508 SecY translocase; Region: SecY; pfam00344 222523000509 adenylate kinase; Reviewed; Region: adk; PRK00279 222523000510 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 222523000511 AMP-binding site [chemical binding]; other site 222523000512 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 222523000513 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 222523000514 active site 222523000515 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 222523000516 rRNA binding site [nucleotide binding]; other site 222523000517 predicted 30S ribosome binding site; other site 222523000518 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 222523000519 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 222523000520 30S ribosomal protein S13; Region: bact_S13; TIGR03631 222523000521 30S ribosomal protein S11; Validated; Region: PRK05309 222523000522 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 222523000523 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 222523000524 alphaNTD - beta interaction site [polypeptide binding]; other site 222523000525 alphaNTD homodimer interface [polypeptide binding]; other site 222523000526 alphaNTD - beta' interaction site [polypeptide binding]; other site 222523000527 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 222523000528 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 222523000529 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 222523000530 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 222523000531 Walker A/P-loop; other site 222523000532 ATP binding site [chemical binding]; other site 222523000533 Q-loop/lid; other site 222523000534 ABC transporter signature motif; other site 222523000535 Walker B; other site 222523000536 D-loop; other site 222523000537 H-loop/switch region; other site 222523000538 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 222523000539 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 222523000540 Walker A/P-loop; other site 222523000541 ATP binding site [chemical binding]; other site 222523000542 Q-loop/lid; other site 222523000543 ABC transporter signature motif; other site 222523000544 Walker B; other site 222523000545 D-loop; other site 222523000546 H-loop/switch region; other site 222523000547 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 222523000548 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 222523000549 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 222523000550 dimerization interface 3.5A [polypeptide binding]; other site 222523000551 active site 222523000552 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 222523000553 23S rRNA interface [nucleotide binding]; other site 222523000554 L3 interface [polypeptide binding]; other site 222523000555 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 222523000556 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 222523000557 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 222523000558 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 222523000559 active site 222523000560 metal binding site [ion binding]; metal-binding site 222523000561 Domain of unknown function DUF59; Region: DUF59; pfam01883 222523000562 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 222523000563 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 222523000564 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 222523000565 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523000566 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 222523000567 NodB motif; other site 222523000568 putative active site [active] 222523000569 putative catalytic site [active] 222523000570 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 222523000571 Arginase family; Region: Arginase; cd09989 222523000572 agmatinase; Region: agmatinase; TIGR01230 222523000573 active site 222523000574 Mn binding site [ion binding]; other site 222523000575 oligomer interface [polypeptide binding]; other site 222523000576 Uncharacterized conserved protein [Function unknown]; Region: COG1624 222523000577 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 222523000578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 222523000579 YbbR-like protein; Region: YbbR; pfam07949 222523000580 YbbR-like protein; Region: YbbR; pfam07949 222523000581 YbbR-like protein; Region: YbbR; pfam07949 222523000582 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 222523000583 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 222523000584 active site 222523000585 substrate binding site [chemical binding]; other site 222523000586 metal binding site [ion binding]; metal-binding site 222523000587 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 222523000588 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 222523000589 glutaminase active site [active] 222523000590 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 222523000591 dimer interface [polypeptide binding]; other site 222523000592 active site 222523000593 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 222523000594 dimer interface [polypeptide binding]; other site 222523000595 active site 222523000596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 222523000597 TPR repeat; Region: TPR_11; pfam13414 222523000598 binding surface 222523000599 TPR motif; other site 222523000600 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 222523000601 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 222523000602 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 222523000603 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523000604 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523000605 non-specific DNA binding site [nucleotide binding]; other site 222523000606 salt bridge; other site 222523000607 sequence-specific DNA binding site [nucleotide binding]; other site 222523000608 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 222523000609 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 222523000610 putative active site [active] 222523000611 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523000612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523000613 Walker A/P-loop; other site 222523000614 ATP binding site [chemical binding]; other site 222523000615 Q-loop/lid; other site 222523000616 ABC transporter signature motif; other site 222523000617 Walker B; other site 222523000618 D-loop; other site 222523000619 H-loop/switch region; other site 222523000620 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 222523000621 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 222523000622 HlyD family secretion protein; Region: HlyD_3; pfam13437 222523000623 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 222523000624 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 222523000625 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 222523000626 AAA domain; Region: AAA_22; pfam13401 222523000627 TniQ; Region: TniQ; pfam06527 222523000628 TniQ; Region: TniQ; pfam06527 222523000629 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 222523000630 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 222523000631 Integrase core domain; Region: rve; pfam00665 222523000632 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 222523000633 AAA domain; Region: AAA_22; pfam13401 222523000634 Walker A motif; other site 222523000635 ATP binding site [chemical binding]; other site 222523000636 Walker B motif; other site 222523000637 TniQ; Region: TniQ; pfam06527 222523000638 eyes absent protein conserved domain; Region: EYA-cons_domain; TIGR01658 222523000639 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 222523000640 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 222523000641 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 222523000642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523000643 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 222523000644 classical (c) SDRs; Region: SDR_c; cd05233 222523000645 NAD(P) binding site [chemical binding]; other site 222523000646 active site 222523000647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523000648 ABC-ATPase subunit interface; other site 222523000649 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 222523000650 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 222523000651 Walker A/P-loop; other site 222523000652 ATP binding site [chemical binding]; other site 222523000653 Q-loop/lid; other site 222523000654 ABC transporter signature motif; other site 222523000655 Walker B; other site 222523000656 D-loop; other site 222523000657 H-loop/switch region; other site 222523000658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 222523000659 NIL domain; Region: NIL; pfam09383 222523000660 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 222523000661 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 222523000662 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523000663 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 222523000664 putative NAD(P) binding site [chemical binding]; other site 222523000665 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 222523000666 FAD binding domain; Region: FAD_binding_4; pfam01565 222523000667 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 222523000668 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523000669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523000670 putative substrate translocation pore; other site 222523000671 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 222523000672 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 222523000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523000674 putative substrate translocation pore; other site 222523000675 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 222523000676 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 222523000677 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523000678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523000679 dimer interface [polypeptide binding]; other site 222523000680 conserved gate region; other site 222523000681 putative PBP binding loops; other site 222523000682 ABC-ATPase subunit interface; other site 222523000683 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523000684 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 222523000685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523000686 dimer interface [polypeptide binding]; other site 222523000687 conserved gate region; other site 222523000688 putative PBP binding loops; other site 222523000689 ABC-ATPase subunit interface; other site 222523000690 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 222523000691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523000692 Walker A/P-loop; other site 222523000693 ATP binding site [chemical binding]; other site 222523000694 Q-loop/lid; other site 222523000695 ABC transporter signature motif; other site 222523000696 Walker B; other site 222523000697 D-loop; other site 222523000698 H-loop/switch region; other site 222523000699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 222523000700 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 222523000701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523000702 Walker A/P-loop; other site 222523000703 ATP binding site [chemical binding]; other site 222523000704 Q-loop/lid; other site 222523000705 ABC transporter signature motif; other site 222523000706 Walker B; other site 222523000707 D-loop; other site 222523000708 H-loop/switch region; other site 222523000709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 222523000710 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523000711 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523000712 peptide binding site [polypeptide binding]; other site 222523000713 YusW-like protein; Region: YusW; pfam14039 222523000714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 222523000715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523000716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523000717 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 222523000718 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 222523000719 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523000720 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523000721 peptide binding site [polypeptide binding]; other site 222523000722 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523000723 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523000724 peptide binding site [polypeptide binding]; other site 222523000725 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 222523000726 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 222523000727 active site 222523000728 catalytic tetrad [active] 222523000729 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 222523000730 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 222523000731 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 222523000732 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 222523000733 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 222523000734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523000735 dimer interface [polypeptide binding]; other site 222523000736 conserved gate region; other site 222523000737 putative PBP binding loops; other site 222523000738 ABC-ATPase subunit interface; other site 222523000739 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 222523000740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 222523000741 DNA binding domain, excisionase family; Region: excise; TIGR01764 222523000742 PBP superfamily domain; Region: PBP_like; pfam12727 222523000743 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 222523000744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523000745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523000746 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 222523000747 putative dimerization interface [polypeptide binding]; other site 222523000748 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523000749 EamA-like transporter family; Region: EamA; pfam00892 222523000750 YrzO-like protein; Region: YrzO; pfam14142 222523000751 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 222523000752 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 222523000753 putative acyl-acceptor binding pocket; other site 222523000754 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523000755 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523000756 DNA binding site [nucleotide binding] 222523000757 domain linker motif; other site 222523000758 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 222523000759 putative ligand binding site [chemical binding]; other site 222523000760 putative dimerization interface [polypeptide binding]; other site 222523000761 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523000762 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523000763 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523000764 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523000765 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 222523000766 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 222523000767 active site 222523000768 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 222523000769 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 222523000770 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 222523000771 lysozyme catalytic site [active] 222523000772 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 222523000773 nucleotide binding site/active site [active] 222523000774 HIT family signature motif; other site 222523000775 catalytic residue [active] 222523000776 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 222523000777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523000778 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523000779 ABC transporter; Region: ABC_tran_2; pfam12848 222523000780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523000781 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 222523000782 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 222523000783 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 222523000784 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 222523000785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523000786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523000787 dimer interface [polypeptide binding]; other site 222523000788 conserved gate region; other site 222523000789 putative PBP binding loops; other site 222523000790 ABC-ATPase subunit interface; other site 222523000791 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523000792 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 222523000793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523000794 dimer interface [polypeptide binding]; other site 222523000795 conserved gate region; other site 222523000796 putative PBP binding loops; other site 222523000797 ABC-ATPase subunit interface; other site 222523000798 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 222523000799 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523000800 Walker A/P-loop; other site 222523000801 ATP binding site [chemical binding]; other site 222523000802 Q-loop/lid; other site 222523000803 ABC transporter signature motif; other site 222523000804 Walker B; other site 222523000805 D-loop; other site 222523000806 H-loop/switch region; other site 222523000807 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 222523000808 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 222523000809 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523000810 Walker A/P-loop; other site 222523000811 ATP binding site [chemical binding]; other site 222523000812 Q-loop/lid; other site 222523000813 ABC transporter signature motif; other site 222523000814 Walker B; other site 222523000815 D-loop; other site 222523000816 H-loop/switch region; other site 222523000817 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 222523000818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523000819 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523000820 active site 222523000821 motif I; other site 222523000822 motif II; other site 222523000823 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523000824 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 222523000825 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 222523000826 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 222523000827 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 222523000828 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 222523000829 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 222523000830 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 222523000831 dimer interface [polypeptide binding]; other site 222523000832 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 222523000833 active site 222523000834 Fe binding site [ion binding]; other site 222523000835 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 222523000836 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 222523000837 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 222523000838 amino acid transporter; Region: 2A0306; TIGR00909 222523000839 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 222523000840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523000841 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523000842 putative substrate translocation pore; other site 222523000843 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 222523000844 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 222523000845 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 222523000846 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 222523000847 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 222523000848 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523000849 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523000850 helicase 45; Provisional; Region: PTZ00424 222523000851 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 222523000852 ATP binding site [chemical binding]; other site 222523000853 Mg++ binding site [ion binding]; other site 222523000854 motif III; other site 222523000855 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523000856 nucleotide binding region [chemical binding]; other site 222523000857 ATP-binding site [chemical binding]; other site 222523000858 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 222523000859 Rhomboid family; Region: Rhomboid; pfam01694 222523000860 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 222523000861 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 222523000862 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 222523000863 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 222523000864 alanine racemase; Reviewed; Region: alr; PRK00053 222523000865 active site 222523000866 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 222523000867 dimer interface [polypeptide binding]; other site 222523000868 substrate binding site [chemical binding]; other site 222523000869 catalytic residues [active] 222523000870 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 222523000871 PemK-like protein; Region: PemK; pfam02452 222523000872 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 222523000873 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 222523000874 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 222523000875 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 222523000876 RNA binding site [nucleotide binding]; other site 222523000877 SprT homologues; Region: SprT; cl01182 222523000878 SprT-like family; Region: SprT-like; pfam10263 222523000879 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 222523000880 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 222523000881 Glycoprotease family; Region: Peptidase_M22; pfam00814 222523000882 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 222523000883 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 222523000884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523000885 Coenzyme A binding pocket [chemical binding]; other site 222523000886 UGMP family protein; Validated; Region: PRK09604 222523000887 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 222523000888 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 222523000889 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 222523000890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523000891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523000892 ABC transporter; Region: ABC_tran_2; pfam12848 222523000893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523000894 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 222523000895 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 222523000896 CoA binding domain; Region: CoA_binding; pfam02629 222523000897 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 222523000898 CAAX protease self-immunity; Region: Abi; pfam02517 222523000899 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 222523000900 oligomerisation interface [polypeptide binding]; other site 222523000901 mobile loop; other site 222523000902 roof hairpin; other site 222523000903 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 222523000904 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 222523000905 ring oligomerisation interface [polypeptide binding]; other site 222523000906 ATP/Mg binding site [chemical binding]; other site 222523000907 hinge regions; other site 222523000908 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 222523000909 GMP synthase; Reviewed; Region: guaA; PRK00074 222523000910 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 222523000911 AMP/PPi binding site [chemical binding]; other site 222523000912 candidate oxyanion hole; other site 222523000913 catalytic triad [active] 222523000914 potential glutamine specificity residues [chemical binding]; other site 222523000915 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 222523000916 ATP Binding subdomain [chemical binding]; other site 222523000917 Ligand Binding sites [chemical binding]; other site 222523000918 Dimerization subdomain; other site 222523000919 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 222523000920 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523000921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523000922 active site 222523000923 phosphorylation site [posttranslational modification] 222523000924 intermolecular recognition site; other site 222523000925 dimerization interface [polypeptide binding]; other site 222523000926 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523000927 DNA binding site [nucleotide binding] 222523000928 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523000929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523000930 dimerization interface [polypeptide binding]; other site 222523000931 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523000932 dimer interface [polypeptide binding]; other site 222523000933 phosphorylation site [posttranslational modification] 222523000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523000935 ATP binding site [chemical binding]; other site 222523000936 Mg2+ binding site [ion binding]; other site 222523000937 G-X-G motif; other site 222523000938 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 222523000939 putative ligand binding site [chemical binding]; other site 222523000940 putative catalytic site [active] 222523000941 Methyltransferase domain; Region: Methyltransf_11; pfam08241 222523000942 Putative methyltransferase; Region: Methyltransf_4; cl17290 222523000943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523000944 S-adenosylmethionine binding site [chemical binding]; other site 222523000945 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 222523000946 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 222523000947 UDP-glucose 4-epimerase (G4E), subgroup 5, extended (e) SDRs; Region: UDP_G4E_5_SDR_e; cd05264 222523000948 putative NAD(P) binding site [chemical binding]; other site 222523000949 active site 222523000950 putative substrate binding site [chemical binding]; other site 222523000951 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523000952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523000953 S-adenosylmethionine binding site [chemical binding]; other site 222523000954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 222523000955 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 222523000956 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 222523000957 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523000958 active site 222523000959 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 222523000960 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 222523000961 aspartate racemase; Region: asp_race; TIGR00035 222523000962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523000963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523000964 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523000965 dimerization interface [polypeptide binding]; other site 222523000966 Probable transposase; Region: OrfB_IS605; pfam01385 222523000967 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523000968 EamA-like transporter family; Region: EamA; pfam00892 222523000969 EamA-like transporter family; Region: EamA; pfam00892 222523000970 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 222523000971 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 222523000972 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 222523000973 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 222523000974 NAD binding site [chemical binding]; other site 222523000975 ATP-grasp domain; Region: ATP-grasp; pfam02222 222523000976 adenylosuccinate lyase; Provisional; Region: PRK07492 222523000977 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 222523000978 tetramer interface [polypeptide binding]; other site 222523000979 active site 222523000980 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 222523000981 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 222523000982 ATP binding site [chemical binding]; other site 222523000983 active site 222523000984 substrate binding site [chemical binding]; other site 222523000985 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 222523000986 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 222523000987 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 222523000988 putative active site [active] 222523000989 catalytic triad [active] 222523000990 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 222523000991 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 222523000992 dimerization interface [polypeptide binding]; other site 222523000993 ATP binding site [chemical binding]; other site 222523000994 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 222523000995 dimerization interface [polypeptide binding]; other site 222523000996 ATP binding site [chemical binding]; other site 222523000997 amidophosphoribosyltransferase; Provisional; Region: PRK06781 222523000998 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 222523000999 active site 222523001000 tetramer interface [polypeptide binding]; other site 222523001001 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523001002 active site 222523001003 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 222523001004 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 222523001005 dimerization interface [polypeptide binding]; other site 222523001006 putative ATP binding site [chemical binding]; other site 222523001007 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 222523001008 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 222523001009 active site 222523001010 substrate binding site [chemical binding]; other site 222523001011 cosubstrate binding site; other site 222523001012 catalytic site [active] 222523001013 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 222523001014 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 222523001015 purine monophosphate binding site [chemical binding]; other site 222523001016 dimer interface [polypeptide binding]; other site 222523001017 putative catalytic residues [active] 222523001018 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 222523001019 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 222523001020 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 222523001021 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 222523001022 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 222523001023 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 222523001024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 222523001025 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 222523001026 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 222523001027 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 222523001028 PcrB family; Region: PcrB; pfam01884 222523001029 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 222523001030 substrate binding site [chemical binding]; other site 222523001031 putative active site [active] 222523001032 dimer interface [polypeptide binding]; other site 222523001033 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 222523001034 Part of AAA domain; Region: AAA_19; pfam13245 222523001035 Family description; Region: UvrD_C_2; pfam13538 222523001036 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 222523001037 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 222523001038 nucleotide binding pocket [chemical binding]; other site 222523001039 K-X-D-G motif; other site 222523001040 catalytic site [active] 222523001041 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 222523001042 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 222523001043 Dimer interface [polypeptide binding]; other site 222523001044 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 222523001045 putative dimer interface [polypeptide binding]; other site 222523001046 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 222523001047 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 222523001048 putative dimer interface [polypeptide binding]; other site 222523001049 hypothetical protein; Provisional; Region: PRK10621 222523001050 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523001051 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 222523001052 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 222523001053 Glutamate binding site [chemical binding]; other site 222523001054 homodimer interface [polypeptide binding]; other site 222523001055 NAD binding site [chemical binding]; other site 222523001056 catalytic residues [active] 222523001057 Isochorismatase family; Region: Isochorismatase; pfam00857 222523001058 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 222523001059 catalytic triad [active] 222523001060 conserved cis-peptide bond; other site 222523001061 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 222523001062 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 222523001063 Walker A/P-loop; other site 222523001064 ATP binding site [chemical binding]; other site 222523001065 Q-loop/lid; other site 222523001066 ABC transporter signature motif; other site 222523001067 Walker B; other site 222523001068 D-loop; other site 222523001069 H-loop/switch region; other site 222523001070 NIL domain; Region: NIL; pfam09383 222523001071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523001072 dimer interface [polypeptide binding]; other site 222523001073 conserved gate region; other site 222523001074 ABC-ATPase subunit interface; other site 222523001075 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 222523001076 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 222523001077 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 222523001078 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 222523001079 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 222523001080 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 222523001081 P loop; other site 222523001082 Nucleotide binding site [chemical binding]; other site 222523001083 DTAP/Switch II; other site 222523001084 Switch I; other site 222523001085 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 222523001086 putative dimer interface [polypeptide binding]; other site 222523001087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523001088 MarR family; Region: MarR; pfam01047 222523001089 MarR family; Region: MarR_2; cl17246 222523001090 yiaA/B two helix domain; Region: YiaAB; pfam05360 222523001091 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 222523001092 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 222523001093 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 222523001094 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 222523001095 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 222523001096 GatB domain; Region: GatB_Yqey; pfam02637 222523001097 putative lipid kinase; Reviewed; Region: PRK13337 222523001098 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 222523001099 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 222523001100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523001101 motif II; other site 222523001102 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 222523001103 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523001104 inhibitor-cofactor binding pocket; inhibition site 222523001105 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523001106 catalytic residue [active] 222523001107 PAS domain; Region: PAS_9; pfam13426 222523001108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523001109 putative active site [active] 222523001110 heme pocket [chemical binding]; other site 222523001111 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 222523001112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523001113 Walker A motif; other site 222523001114 ATP binding site [chemical binding]; other site 222523001115 Walker B motif; other site 222523001116 arginine finger; other site 222523001117 succinic semialdehyde dehydrogenase; Region: PLN02278 222523001118 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 222523001119 tetramerization interface [polypeptide binding]; other site 222523001120 NAD(P) binding site [chemical binding]; other site 222523001121 catalytic residues [active] 222523001122 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 222523001123 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 222523001124 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 222523001125 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 222523001126 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523001127 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 222523001128 putative active site [active] 222523001129 putative metal binding site [ion binding]; other site 222523001130 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523001131 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523001132 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523001133 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 222523001134 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 222523001135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523001136 S-adenosylmethionine binding site [chemical binding]; other site 222523001137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523001138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523001139 non-specific DNA binding site [nucleotide binding]; other site 222523001140 salt bridge; other site 222523001141 sequence-specific DNA binding site [nucleotide binding]; other site 222523001142 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 222523001143 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 222523001144 cofactor binding site; other site 222523001145 DNA binding site [nucleotide binding] 222523001146 substrate interaction site [chemical binding]; other site 222523001147 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 222523001148 homodimer interface [polypeptide binding]; other site 222523001149 putative active site [active] 222523001150 catalytic site [active] 222523001151 Z1 domain; Region: Z1; pfam10593 222523001152 Putative catalytic domain of type II restriction enzyme NgoFVII and similar proteins; Region: PLDc_RE_NgoFVII; cd09177 222523001153 PLD-like domain; Region: PLDc_2; pfam13091 222523001154 putative homodimer interface [polypeptide binding]; other site 222523001155 putative active site [active] 222523001156 catalytic site [active] 222523001157 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 222523001158 non-specific DNA binding site [nucleotide binding]; other site 222523001159 salt bridge; other site 222523001160 sequence-specific DNA binding site [nucleotide binding]; other site 222523001161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523001162 non-specific DNA binding site [nucleotide binding]; other site 222523001163 salt bridge; other site 222523001164 sequence-specific DNA binding site [nucleotide binding]; other site 222523001165 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 222523001166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 222523001167 DNA binding residues [nucleotide binding] 222523001168 Protein of unknown function (DUF2800); Region: DUF2800; pfam10926 222523001169 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 222523001170 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 222523001171 active site 222523001172 DNA binding site [nucleotide binding] 222523001173 catalytic site [active] 222523001174 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523001175 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523001176 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 222523001177 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 222523001178 AntA/AntB antirepressor; Region: AntA; pfam08346 222523001179 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 222523001180 Virulence-associated protein E; Region: VirE; pfam05272 222523001181 VRR-NUC domain; Region: VRR_NUC; pfam08774 222523001182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523001183 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 222523001184 ATP binding site [chemical binding]; other site 222523001185 putative Mg++ binding site [ion binding]; other site 222523001186 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523001187 DNA binding residues [nucleotide binding] 222523001188 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 222523001189 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 222523001190 active site 222523001191 Phage terminase, small subunit; Region: Terminase_4; cl01525 222523001192 S-adenosylmethionine synthetase; Provisional; Region: PRK12459 222523001193 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 222523001194 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 222523001195 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 222523001196 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 222523001197 ParB-like nuclease domain; Region: ParB; smart00470 222523001198 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 222523001199 DNA methylase; Region: N6_N4_Mtase; pfam01555 222523001200 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 222523001201 cofactor binding site; other site 222523001202 DNA binding site [nucleotide binding] 222523001203 substrate interaction site [chemical binding]; other site 222523001204 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 222523001205 Domain of unknown function (DUF4314); Region: DUF4314; pfam14192 222523001206 Phage Terminase; Region: Terminase_1; pfam03354 222523001207 Phage-related protein [Function unknown]; Region: COG4695 222523001208 Phage portal protein; Region: Phage_portal; pfam04860 222523001209 Clp protease; Region: CLP_protease; pfam00574 222523001210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 222523001211 oligomer interface [polypeptide binding]; other site 222523001212 active site residues [active] 222523001213 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 222523001214 Phage capsid family; Region: Phage_capsid; pfam05065 222523001215 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 222523001216 oligomerization interface [polypeptide binding]; other site 222523001217 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 222523001218 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 222523001219 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 222523001220 Phage-related minor tail protein [Function unknown]; Region: COG5280 222523001221 membrane protein P6; Region: PHA01399 222523001222 Phage tail protein; Region: Sipho_tail; pfam05709 222523001223 Holin family; Region: Phage_holin_4; pfam05105 222523001224 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 222523001225 amidase catalytic site [active] 222523001226 Zn binding residues [ion binding]; other site 222523001227 substrate binding site [chemical binding]; other site 222523001228 Sporulation related domain; Region: SPOR; pfam05036 222523001229 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 222523001230 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523001231 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523001232 catalytic residues [active] 222523001233 catalytic nucleophile [active] 222523001234 Recombinase; Region: Recombinase; pfam07508 222523001235 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 222523001236 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523001237 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523001238 catalytic residues [active] 222523001239 catalytic nucleophile [active] 222523001240 Recombinase; Region: Recombinase; pfam07508 222523001241 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 222523001242 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523001243 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 222523001244 DNA binding residues [nucleotide binding] 222523001245 dimer interface [polypeptide binding]; other site 222523001246 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 222523001247 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 222523001248 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 222523001249 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 222523001250 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 222523001251 FMN binding site [chemical binding]; other site 222523001252 active site 222523001253 catalytic residues [active] 222523001254 substrate binding site [chemical binding]; other site 222523001255 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 222523001256 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 222523001257 GAF domain; Region: GAF_3; pfam13492 222523001258 PAS domain; Region: PAS_9; pfam13426 222523001259 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523001260 dimer interface [polypeptide binding]; other site 222523001261 phosphorylation site [posttranslational modification] 222523001262 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523001263 ATP binding site [chemical binding]; other site 222523001264 Mg2+ binding site [ion binding]; other site 222523001265 G-X-G motif; other site 222523001266 Protein of unknown function DUF91; Region: DUF91; cl00709 222523001267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 222523001268 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 222523001269 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 222523001270 Protein of unknown function DUF45; Region: DUF45; pfam01863 222523001271 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 222523001272 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 222523001273 active site 222523001274 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 222523001275 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 222523001276 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 222523001277 metal binding site [ion binding]; metal-binding site 222523001278 putative dimer interface [polypeptide binding]; other site 222523001279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523001280 S-adenosylmethionine binding site [chemical binding]; other site 222523001281 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 222523001282 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 222523001283 catalytic residue [active] 222523001284 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 222523001285 catalytic residues [active] 222523001286 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523001287 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523001288 peroxiredoxin; Region: AhpC; TIGR03137 222523001289 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 222523001290 dimer interface [polypeptide binding]; other site 222523001291 decamer (pentamer of dimers) interface [polypeptide binding]; other site 222523001292 catalytic triad [active] 222523001293 peroxidatic and resolving cysteines [active] 222523001294 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 222523001295 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 222523001296 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 222523001297 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 222523001298 intersubunit interface [polypeptide binding]; other site 222523001299 active site 222523001300 Zn2+ binding site [ion binding]; other site 222523001301 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523001302 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523001303 ABC-ATPase subunit interface; other site 222523001304 dimer interface [polypeptide binding]; other site 222523001305 putative PBP binding regions; other site 222523001306 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523001307 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523001308 ABC-ATPase subunit interface; other site 222523001309 dimer interface [polypeptide binding]; other site 222523001310 putative PBP binding regions; other site 222523001311 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 222523001312 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 222523001313 putative ligand binding residues [chemical binding]; other site 222523001314 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 222523001315 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523001316 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 222523001317 DNA binding domain, excisionase family; Region: excise; TIGR01764 222523001318 Sm and related proteins; Region: Sm_like; cl00259 222523001319 Sm1 motif; other site 222523001320 RNA binding site [nucleotide binding]; other site 222523001321 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 222523001322 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 222523001323 hypothetical protein; Provisional; Region: PRK06851 222523001324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523001325 Walker A motif; other site 222523001326 ATP binding site [chemical binding]; other site 222523001327 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 222523001328 G1 box; other site 222523001329 GTP/Mg2+ binding site [chemical binding]; other site 222523001330 G2 box; other site 222523001331 Switch I region; other site 222523001332 G3 box; other site 222523001333 Switch II region; other site 222523001334 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 222523001335 benzoate transport; Region: 2A0115; TIGR00895 222523001336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523001337 putative substrate translocation pore; other site 222523001338 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 222523001339 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 222523001340 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 222523001341 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 222523001342 [2Fe-2S] cluster binding site [ion binding]; other site 222523001343 Fatty acid desaturase; Region: FA_desaturase; pfam00487 222523001344 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 222523001345 putative di-iron ligands [ion binding]; other site 222523001346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523001347 dimer interface [polypeptide binding]; other site 222523001348 conserved gate region; other site 222523001349 putative PBP binding loops; other site 222523001350 ABC-ATPase subunit interface; other site 222523001351 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 222523001352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523001353 substrate binding pocket [chemical binding]; other site 222523001354 membrane-bound complex binding site; other site 222523001355 hinge residues; other site 222523001356 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523001357 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523001358 Walker A/P-loop; other site 222523001359 ATP binding site [chemical binding]; other site 222523001360 Q-loop/lid; other site 222523001361 ABC transporter signature motif; other site 222523001362 Walker B; other site 222523001363 D-loop; other site 222523001364 H-loop/switch region; other site 222523001365 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 222523001366 HAMP domain; Region: HAMP; pfam00672 222523001367 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523001368 dimer interface [polypeptide binding]; other site 222523001369 putative CheW interface [polypeptide binding]; other site 222523001370 Arginine repressor [Transcription]; Region: ArgR; COG1438 222523001371 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 222523001372 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 222523001373 arginine deiminase; Provisional; Region: PRK01388 222523001374 ornithine carbamoyltransferase; Validated; Region: PRK02102 222523001375 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 222523001376 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 222523001377 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 222523001378 carbamate kinase; Reviewed; Region: PRK12686 222523001379 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 222523001380 putative substrate binding site [chemical binding]; other site 222523001381 nucleotide binding site [chemical binding]; other site 222523001382 nucleotide binding site [chemical binding]; other site 222523001383 homodimer interface [polypeptide binding]; other site 222523001384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 222523001385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 222523001386 ligand binding site [chemical binding]; other site 222523001387 flexible hinge region; other site 222523001388 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 222523001389 putative switch regulator; other site 222523001390 non-specific DNA interactions [nucleotide binding]; other site 222523001391 DNA binding site [nucleotide binding] 222523001392 sequence specific DNA binding site [nucleotide binding]; other site 222523001393 putative cAMP binding site [chemical binding]; other site 222523001394 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 222523001395 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 222523001396 Berberine and berberine like; Region: BBE; pfam08031 222523001397 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 222523001398 FAD binding domain; Region: FAD_binding_4; pfam01565 222523001399 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 222523001400 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 222523001401 Ca binding site [ion binding]; other site 222523001402 active site 222523001403 catalytic site [active] 222523001404 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 222523001405 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 222523001406 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 222523001407 active site turn [active] 222523001408 phosphorylation site [posttranslational modification] 222523001409 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 222523001410 putative catalytic site [active] 222523001411 putative metal binding site [ion binding]; other site 222523001412 putative phosphate binding site [ion binding]; other site 222523001413 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 222523001414 Predicted membrane protein [Function unknown]; Region: COG1511 222523001415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523001416 DNA topoisomerase III; Provisional; Region: PRK07726 222523001417 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 222523001418 active site 222523001419 putative interdomain interaction site [polypeptide binding]; other site 222523001420 putative metal-binding site [ion binding]; other site 222523001421 putative nucleotide binding site [chemical binding]; other site 222523001422 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 222523001423 domain I; other site 222523001424 DNA binding groove [nucleotide binding] 222523001425 phosphate binding site [ion binding]; other site 222523001426 domain II; other site 222523001427 domain III; other site 222523001428 nucleotide binding site [chemical binding]; other site 222523001429 catalytic site [active] 222523001430 domain IV; other site 222523001431 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 222523001432 substrate binding site [chemical binding]; other site 222523001433 multimerization interface [polypeptide binding]; other site 222523001434 ATP binding site [chemical binding]; other site 222523001435 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 222523001436 thiamine phosphate binding site [chemical binding]; other site 222523001437 active site 222523001438 pyrophosphate binding site [ion binding]; other site 222523001439 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 222523001440 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 222523001441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523001442 dimerization interface [polypeptide binding]; other site 222523001443 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523001444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523001445 dimer interface [polypeptide binding]; other site 222523001446 putative CheW interface [polypeptide binding]; other site 222523001447 Domain of unknown function DUF77; Region: DUF77; pfam01910 222523001448 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 222523001449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523001450 dimer interface [polypeptide binding]; other site 222523001451 conserved gate region; other site 222523001452 putative PBP binding loops; other site 222523001453 ABC-ATPase subunit interface; other site 222523001454 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 222523001455 NMT1/THI5 like; Region: NMT1; pfam09084 222523001456 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 222523001457 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 222523001458 Walker A/P-loop; other site 222523001459 ATP binding site [chemical binding]; other site 222523001460 Q-loop/lid; other site 222523001461 ABC transporter signature motif; other site 222523001462 Walker B; other site 222523001463 D-loop; other site 222523001464 H-loop/switch region; other site 222523001465 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 222523001466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523001467 Walker A/P-loop; other site 222523001468 ATP binding site [chemical binding]; other site 222523001469 Q-loop/lid; other site 222523001470 ABC transporter signature motif; other site 222523001471 Walker B; other site 222523001472 D-loop; other site 222523001473 H-loop/switch region; other site 222523001474 ABC transporter; Region: ABC_tran_2; pfam12848 222523001475 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523001476 Glyco_18 domain; Region: Glyco_18; smart00636 222523001477 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 222523001478 active site 222523001479 CBD_II domain; Region: CBD_II; smart00637 222523001480 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 222523001481 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523001482 catalytic residues [active] 222523001483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523001484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523001485 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 222523001486 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523001487 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523001488 putative substrate translocation pore; other site 222523001489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523001490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523001491 non-specific DNA binding site [nucleotide binding]; other site 222523001492 salt bridge; other site 222523001493 sequence-specific DNA binding site [nucleotide binding]; other site 222523001494 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 222523001495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523001496 putative substrate translocation pore; other site 222523001497 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 222523001498 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 222523001499 YesK-like protein; Region: YesK; pfam14150 222523001500 prolyl-tRNA synthetase; Provisional; Region: PRK08661 222523001501 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 222523001502 dimer interface [polypeptide binding]; other site 222523001503 motif 1; other site 222523001504 active site 222523001505 motif 2; other site 222523001506 motif 3; other site 222523001507 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 222523001508 anticodon binding site; other site 222523001509 zinc-binding site [ion binding]; other site 222523001510 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 222523001511 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 222523001512 nucleotide binding site [chemical binding]; other site 222523001513 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 222523001514 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 222523001515 putative metal binding site [ion binding]; other site 222523001516 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 222523001517 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 222523001518 putative metal binding site [ion binding]; other site 222523001519 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 222523001520 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 222523001521 putative metal binding site [ion binding]; other site 222523001522 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 222523001523 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 222523001524 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 222523001525 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 222523001526 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 222523001527 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523001528 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 222523001529 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 222523001530 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 222523001531 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 222523001532 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 222523001533 Low molecular weight phosphatase family; Region: LMWPc; cd00115 222523001534 active site 222523001535 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 222523001536 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 222523001537 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 222523001538 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523001539 Soluble P-type ATPase [General function prediction only]; Region: COG4087 222523001540 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523001541 EamA-like transporter family; Region: EamA; pfam00892 222523001542 EamA-like transporter family; Region: EamA; pfam00892 222523001543 YhhN-like protein; Region: YhhN; pfam07947 222523001544 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 222523001545 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523001546 Catalytic site [active] 222523001547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523001548 binding surface 222523001549 Tetratricopeptide repeat; Region: TPR_16; pfam13432 222523001550 TPR motif; other site 222523001551 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 222523001552 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523001553 Predicted membrane protein [Function unknown]; Region: COG2510 222523001554 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 222523001555 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 222523001556 calcium/proton exchanger (cax); Region: cax; TIGR00378 222523001557 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 222523001558 YfkD-like protein; Region: YfkD; pfam14167 222523001559 Radical SAM superfamily; Region: Radical_SAM; pfam04055 222523001560 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523001561 FeS/SAM binding site; other site 222523001562 YfkB-like domain; Region: YfkB; pfam08756 222523001563 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 222523001564 Fumarase C-terminus; Region: Fumerase_C; pfam05683 222523001565 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 222523001566 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 222523001567 NodB motif; other site 222523001568 active site 222523001569 catalytic site [active] 222523001570 Cd binding site [ion binding]; other site 222523001571 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 222523001572 endonuclease III; Region: ENDO3c; smart00478 222523001573 minor groove reading motif; other site 222523001574 helix-hairpin-helix signature motif; other site 222523001575 substrate binding pocket [chemical binding]; other site 222523001576 active site 222523001577 TRAM domain; Region: TRAM; pfam01938 222523001578 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 222523001579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523001580 S-adenosylmethionine binding site [chemical binding]; other site 222523001581 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 222523001582 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 222523001583 dimerization interface 3.5A [polypeptide binding]; other site 222523001584 active site 222523001585 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 222523001586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523001587 Walker A motif; other site 222523001588 ATP binding site [chemical binding]; other site 222523001589 Walker B motif; other site 222523001590 arginine finger; other site 222523001591 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 222523001592 hypothetical protein; Validated; Region: PRK06748 222523001593 S-methylmethionine transporter; Provisional; Region: PRK11387 222523001594 acetylornithine deacetylase; Validated; Region: PRK08596 222523001595 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 222523001596 metal binding site [ion binding]; metal-binding site 222523001597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523001598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523001599 non-specific DNA binding site [nucleotide binding]; other site 222523001600 salt bridge; other site 222523001601 sequence-specific DNA binding site [nucleotide binding]; other site 222523001602 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 222523001603 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 222523001604 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 222523001605 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 222523001606 glutaminase A; Region: Gln_ase; TIGR03814 222523001607 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 222523001608 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 222523001609 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 222523001610 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 222523001611 active site turn [active] 222523001612 phosphorylation site [posttranslational modification] 222523001613 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523001614 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523001615 Sm and related proteins; Region: Sm_like; cl00259 222523001616 heptamer interface [polypeptide binding]; other site 222523001617 Sm1 motif; other site 222523001618 hexamer interface [polypeptide binding]; other site 222523001619 RNA binding site [nucleotide binding]; other site 222523001620 Sm2 motif; other site 222523001621 Sm and related proteins; Region: Sm_like; cl00259 222523001622 heptamer interface [polypeptide binding]; other site 222523001623 Sm1 motif; other site 222523001624 hexamer interface [polypeptide binding]; other site 222523001625 RNA binding site [nucleotide binding]; other site 222523001626 Sm2 motif; other site 222523001627 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 222523001628 active site 222523001629 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 222523001630 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 222523001631 active site 222523001632 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 222523001633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523001634 NAD(P) binding site [chemical binding]; other site 222523001635 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 222523001636 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 222523001637 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 222523001638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523001639 NAD(P) binding site [chemical binding]; other site 222523001640 active site 222523001641 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523001642 active site 222523001643 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 222523001644 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523001645 active site 222523001646 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 222523001647 Pyruvate formate lyase 1; Region: PFL1; cd01678 222523001648 coenzyme A binding site [chemical binding]; other site 222523001649 active site 222523001650 catalytic residues [active] 222523001651 glycine loop; other site 222523001652 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 222523001653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523001654 FeS/SAM binding site; other site 222523001655 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 222523001656 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 222523001657 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 222523001658 YfhE-like protein; Region: YfhE; pfam14152 222523001659 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523001660 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 222523001661 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 222523001662 active site 222523001663 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 222523001664 TIGR01777 family protein; Region: yfcH 222523001665 putative NAD(P) binding site [chemical binding]; other site 222523001666 putative active site [active] 222523001667 recombination regulator RecX; Provisional; Region: recX; PRK14135 222523001668 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 222523001669 YpzG-like protein; Region: YpzG; pfam14139 222523001670 Small acid-soluble spore protein K family; Region: SspK; pfam08176 222523001671 WVELL protein; Region: WVELL; pfam14043 222523001672 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 222523001673 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 222523001674 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 222523001675 minor groove reading motif; other site 222523001676 helix-hairpin-helix signature motif; other site 222523001677 substrate binding pocket [chemical binding]; other site 222523001678 active site 222523001679 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 222523001680 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 222523001681 DNA binding and oxoG recognition site [nucleotide binding] 222523001682 YgaB-like protein; Region: YgaB; pfam14182 222523001683 hypothetical protein; Provisional; Region: PRK13662 222523001684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523001685 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523001686 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 222523001687 Walker A/P-loop; other site 222523001688 ATP binding site [chemical binding]; other site 222523001689 Q-loop/lid; other site 222523001690 ABC transporter signature motif; other site 222523001691 Walker B; other site 222523001692 D-loop; other site 222523001693 H-loop/switch region; other site 222523001694 Predicted membrane protein [Function unknown]; Region: COG4129 222523001695 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 222523001696 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 222523001697 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 222523001698 active site 222523001699 dimer interface [polypeptide binding]; other site 222523001700 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 222523001701 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 222523001702 active site 222523001703 FMN binding site [chemical binding]; other site 222523001704 substrate binding site [chemical binding]; other site 222523001705 3Fe-4S cluster binding site [ion binding]; other site 222523001706 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 222523001707 domain_subunit interface; other site 222523001708 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 222523001709 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523001710 inhibitor-cofactor binding pocket; inhibition site 222523001711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523001712 catalytic residue [active] 222523001713 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 222523001714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523001715 Walker A/P-loop; other site 222523001716 ATP binding site [chemical binding]; other site 222523001717 Q-loop/lid; other site 222523001718 ABC transporter signature motif; other site 222523001719 Walker B; other site 222523001720 D-loop; other site 222523001721 H-loop/switch region; other site 222523001722 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 222523001723 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 222523001724 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 222523001725 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 222523001726 Ion channel; Region: Ion_trans_2; pfam07885 222523001727 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 222523001728 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 222523001729 catalytic triad [active] 222523001730 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 222523001731 metal binding site 2 [ion binding]; metal-binding site 222523001732 putative DNA binding helix; other site 222523001733 metal binding site 1 [ion binding]; metal-binding site 222523001734 dimer interface [polypeptide binding]; other site 222523001735 structural Zn2+ binding site [ion binding]; other site 222523001736 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 222523001737 hypothetical protein; Provisional; Region: PRK12378 222523001738 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 222523001739 nudix motif; other site 222523001740 Transglycosylase; Region: Transgly; pfam00912 222523001741 Thioredoxin; Region: Thioredoxin_4; pfam13462 222523001742 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 222523001743 epoxyqueuosine reductase; Region: TIGR00276 222523001744 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 222523001745 Putative amidase domain; Region: Amidase_6; pfam12671 222523001746 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 222523001747 PAS fold; Region: PAS_4; pfam08448 222523001748 PAS domain; Region: PAS_9; pfam13426 222523001749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523001750 putative active site [active] 222523001751 heme pocket [chemical binding]; other site 222523001752 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 222523001753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523001754 metal binding site [ion binding]; metal-binding site 222523001755 active site 222523001756 I-site; other site 222523001757 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 222523001758 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 222523001759 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 222523001760 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 222523001761 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523001762 heme-binding site [chemical binding]; other site 222523001763 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001764 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001765 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001766 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001767 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001768 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001769 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 222523001770 Leucine-rich repeats; other site 222523001771 Substrate binding site [chemical binding]; other site 222523001772 Leucine rich repeat; Region: LRR_8; pfam13855 222523001773 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523001774 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 222523001775 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 222523001776 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523001777 substrate binding pocket [chemical binding]; other site 222523001778 membrane-bound complex binding site; other site 222523001779 hinge residues; other site 222523001780 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523001781 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523001782 Walker A/P-loop; other site 222523001783 ATP binding site [chemical binding]; other site 222523001784 Q-loop/lid; other site 222523001785 ABC transporter signature motif; other site 222523001786 Walker B; other site 222523001787 D-loop; other site 222523001788 H-loop/switch region; other site 222523001789 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 222523001790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523001791 dimer interface [polypeptide binding]; other site 222523001792 conserved gate region; other site 222523001793 putative PBP binding loops; other site 222523001794 ABC-ATPase subunit interface; other site 222523001795 BCCT family transporter; Region: BCCT; pfam02028 222523001796 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 222523001797 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 222523001798 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 222523001799 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 222523001800 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 222523001801 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 222523001802 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 222523001803 Cache domain; Region: Cache_1; pfam02743 222523001804 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523001805 dimerization interface [polypeptide binding]; other site 222523001806 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523001807 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523001808 dimer interface [polypeptide binding]; other site 222523001809 putative CheW interface [polypeptide binding]; other site 222523001810 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 222523001811 PAS domain; Region: PAS_8; pfam13188 222523001812 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523001813 ATP binding site [chemical binding]; other site 222523001814 Mg2+ binding site [ion binding]; other site 222523001815 G-X-G motif; other site 222523001816 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 222523001817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523001818 active site 222523001819 phosphorylation site [posttranslational modification] 222523001820 intermolecular recognition site; other site 222523001821 dimerization interface [polypeptide binding]; other site 222523001822 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 222523001823 Citrate transporter; Region: CitMHS; pfam03600 222523001824 hypothetical protein; Provisional; Region: PRK12784 222523001825 NosL; Region: NosL; cl01769 222523001826 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 222523001827 Ankyrin repeat; Region: Ank; pfam00023 222523001828 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 222523001829 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 222523001830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523001831 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 222523001832 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 222523001833 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523001834 Walker A/P-loop; other site 222523001835 ATP binding site [chemical binding]; other site 222523001836 Q-loop/lid; other site 222523001837 ABC transporter signature motif; other site 222523001838 Walker B; other site 222523001839 D-loop; other site 222523001840 H-loop/switch region; other site 222523001841 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 222523001842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523001843 dimer interface [polypeptide binding]; other site 222523001844 putative PBP binding loops; other site 222523001845 ABC-ATPase subunit interface; other site 222523001846 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 222523001847 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 222523001848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523001849 dimer interface [polypeptide binding]; other site 222523001850 conserved gate region; other site 222523001851 putative PBP binding loops; other site 222523001852 ABC-ATPase subunit interface; other site 222523001853 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 222523001854 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 222523001855 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523001856 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 222523001857 active site 222523001858 metal binding site [ion binding]; metal-binding site 222523001859 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523001860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523001861 active site 222523001862 phosphorylation site [posttranslational modification] 222523001863 intermolecular recognition site; other site 222523001864 dimerization interface [polypeptide binding]; other site 222523001865 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523001866 DNA binding site [nucleotide binding] 222523001867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523001868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523001869 dimer interface [polypeptide binding]; other site 222523001870 phosphorylation site [posttranslational modification] 222523001871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523001872 ATP binding site [chemical binding]; other site 222523001873 Mg2+ binding site [ion binding]; other site 222523001874 G-X-G motif; other site 222523001875 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 222523001876 putative active site [active] 222523001877 sensory histidine kinase DcuS; Provisional; Region: PRK11086 222523001878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523001879 ATP binding site [chemical binding]; other site 222523001880 Mg2+ binding site [ion binding]; other site 222523001881 G-X-G motif; other site 222523001882 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 222523001883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523001884 active site 222523001885 phosphorylation site [posttranslational modification] 222523001886 intermolecular recognition site; other site 222523001887 dimerization interface [polypeptide binding]; other site 222523001888 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 222523001889 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 222523001890 Malic enzyme, N-terminal domain; Region: malic; pfam00390 222523001891 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 222523001892 putative NAD(P) binding site [chemical binding]; other site 222523001893 EamA-like transporter family; Region: EamA; pfam00892 222523001894 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523001895 EamA-like transporter family; Region: EamA; pfam00892 222523001896 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523001897 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523001898 DNA-binding site [nucleotide binding]; DNA binding site 222523001899 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523001900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523001901 homodimer interface [polypeptide binding]; other site 222523001902 catalytic residue [active] 222523001903 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 222523001904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523001905 Coenzyme A binding pocket [chemical binding]; other site 222523001906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523001907 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 222523001908 dimerization interface [polypeptide binding]; other site 222523001909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523001910 dimer interface [polypeptide binding]; other site 222523001911 phosphorylation site [posttranslational modification] 222523001912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523001913 ATP binding site [chemical binding]; other site 222523001914 Mg2+ binding site [ion binding]; other site 222523001915 G-X-G motif; other site 222523001916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523001917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523001918 active site 222523001919 phosphorylation site [posttranslational modification] 222523001920 intermolecular recognition site; other site 222523001921 dimerization interface [polypeptide binding]; other site 222523001922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523001923 DNA binding site [nucleotide binding] 222523001924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 222523001925 Arrestin_N terminal like; Region: LDB19; pfam13002 222523001926 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523001927 Coenzyme A binding pocket [chemical binding]; other site 222523001928 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 222523001929 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 222523001930 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 222523001931 catalytic loop [active] 222523001932 iron binding site [ion binding]; other site 222523001933 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 222523001934 4Fe-4S binding domain; Region: Fer4; pfam00037 222523001935 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 222523001936 [4Fe-4S] binding site [ion binding]; other site 222523001937 molybdopterin cofactor binding site; other site 222523001938 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 222523001939 molybdopterin cofactor binding site; other site 222523001940 Uncharacterized conserved protein [Function unknown]; Region: COG2427 222523001941 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 222523001942 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 222523001943 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 222523001944 putative active site [active] 222523001945 catalytic site [active] 222523001946 putative metal binding site [ion binding]; other site 222523001947 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 222523001948 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 222523001949 hexamer interface [polypeptide binding]; other site 222523001950 ligand binding site [chemical binding]; other site 222523001951 putative active site [active] 222523001952 NAD(P) binding site [chemical binding]; other site 222523001953 amino acid transporter; Region: 2A0306; TIGR00909 222523001954 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 222523001955 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523001956 dimerization interface [polypeptide binding]; other site 222523001957 putative DNA binding site [nucleotide binding]; other site 222523001958 putative Zn2+ binding site [ion binding]; other site 222523001959 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523001960 metal-binding site [ion binding] 222523001961 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523001962 Heavy-metal-associated domain; Region: HMA; pfam00403 222523001963 metal-binding site [ion binding] 222523001964 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523001965 Soluble P-type ATPase [General function prediction only]; Region: COG4087 222523001966 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 222523001967 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 222523001968 active site 222523001969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523001970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523001971 non-specific DNA binding site [nucleotide binding]; other site 222523001972 salt bridge; other site 222523001973 sequence-specific DNA binding site [nucleotide binding]; other site 222523001974 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523001975 TPR motif; other site 222523001976 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523001977 binding surface 222523001978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523001979 binding surface 222523001980 TPR motif; other site 222523001981 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 222523001982 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 222523001983 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 222523001984 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 222523001985 active site 222523001986 Zn binding site [ion binding]; other site 222523001987 Uncharacterized conserved protein [Function unknown]; Region: COG0398 222523001988 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523001989 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 222523001990 VanW like protein; Region: VanW; pfam04294 222523001991 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 222523001992 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523001993 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523001994 Nucleoside recognition; Region: Gate; pfam07670 222523001995 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523001996 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523001997 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 222523001998 putative metal binding site [ion binding]; other site 222523001999 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 222523002000 Domain of unknown function DUF21; Region: DUF21; pfam01595 222523002001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 222523002002 Transporter associated domain; Region: CorC_HlyC; smart01091 222523002003 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 222523002004 Aspartase; Region: Aspartase; cd01357 222523002005 active sites [active] 222523002006 tetramer interface [polypeptide binding]; other site 222523002007 L-lactate permease; Region: Lactate_perm; cl00701 222523002008 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 222523002009 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523002010 dimerization interface [polypeptide binding]; other site 222523002011 putative Zn2+ binding site [ion binding]; other site 222523002012 putative DNA binding site [nucleotide binding]; other site 222523002013 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 222523002014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523002016 putative substrate translocation pore; other site 222523002017 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 222523002018 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 222523002019 siderophore binding site; other site 222523002020 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523002021 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523002022 ABC-ATPase subunit interface; other site 222523002023 dimer interface [polypeptide binding]; other site 222523002024 putative PBP binding regions; other site 222523002025 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 222523002026 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523002027 ABC-ATPase subunit interface; other site 222523002028 dimer interface [polypeptide binding]; other site 222523002029 putative PBP binding regions; other site 222523002030 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 222523002031 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 222523002032 Walker A/P-loop; other site 222523002033 ATP binding site [chemical binding]; other site 222523002034 Q-loop/lid; other site 222523002035 ABC transporter signature motif; other site 222523002036 Walker B; other site 222523002037 D-loop; other site 222523002038 H-loop/switch region; other site 222523002039 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523002040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523002041 S-adenosylmethionine binding site [chemical binding]; other site 222523002042 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 222523002043 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 222523002044 substrate-cofactor binding pocket; other site 222523002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523002046 catalytic residue [active] 222523002047 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 222523002048 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 222523002049 NAD binding site [chemical binding]; other site 222523002050 homodimer interface [polypeptide binding]; other site 222523002051 active site 222523002052 putative substrate binding site [chemical binding]; other site 222523002053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523002054 active site 222523002055 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 222523002056 nudix motif; other site 222523002057 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 222523002058 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 222523002059 metal ion-dependent adhesion site (MIDAS); other site 222523002060 MoxR-like ATPases [General function prediction only]; Region: COG0714 222523002061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523002062 Walker A motif; other site 222523002063 ATP binding site [chemical binding]; other site 222523002064 Walker B motif; other site 222523002065 arginine finger; other site 222523002066 cardiolipin synthetase; Reviewed; Region: PRK12452 222523002067 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 222523002068 putative active site [active] 222523002069 catalytic site [active] 222523002070 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 222523002071 putative active site [active] 222523002072 catalytic site [active] 222523002073 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523002074 PAS domain; Region: PAS_9; pfam13426 222523002075 putative active site [active] 222523002076 heme pocket [chemical binding]; other site 222523002077 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523002078 metal binding site [ion binding]; metal-binding site 222523002079 active site 222523002080 I-site; other site 222523002081 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 222523002082 putrescine transporter; Provisional; Region: potE; PRK10655 222523002083 Spore germination protein; Region: Spore_permease; cl17796 222523002084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523002085 DNA-binding site [nucleotide binding]; DNA binding site 222523002086 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 222523002087 UTRA domain; Region: UTRA; pfam07702 222523002088 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 222523002089 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 222523002090 active site turn [active] 222523002091 phosphorylation site [posttranslational modification] 222523002092 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 222523002093 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 222523002094 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 222523002095 Ca binding site [ion binding]; other site 222523002096 active site 222523002097 catalytic site [active] 222523002098 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 222523002099 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 222523002100 Spore germination protein; Region: Spore_permease; cl17796 222523002101 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523002102 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523002103 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 222523002104 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523002105 active site 222523002106 ATP binding site [chemical binding]; other site 222523002107 substrate binding site [chemical binding]; other site 222523002108 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 222523002109 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 222523002110 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523002111 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523002112 Walker A/P-loop; other site 222523002113 ATP binding site [chemical binding]; other site 222523002114 Q-loop/lid; other site 222523002115 ABC transporter signature motif; other site 222523002116 Walker B; other site 222523002117 D-loop; other site 222523002118 H-loop/switch region; other site 222523002119 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 222523002120 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523002121 substrate binding pocket [chemical binding]; other site 222523002122 membrane-bound complex binding site; other site 222523002123 hinge residues; other site 222523002124 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 222523002125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002126 dimer interface [polypeptide binding]; other site 222523002127 conserved gate region; other site 222523002128 putative PBP binding loops; other site 222523002129 ABC-ATPase subunit interface; other site 222523002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002131 dimer interface [polypeptide binding]; other site 222523002132 conserved gate region; other site 222523002133 putative PBP binding loops; other site 222523002134 ABC-ATPase subunit interface; other site 222523002135 S-methylmethionine transporter; Provisional; Region: PRK11387 222523002136 OsmC-like protein; Region: OsmC; pfam02566 222523002137 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 222523002138 nucleotide binding site/active site [active] 222523002139 HIT family signature motif; other site 222523002140 catalytic residue [active] 222523002141 RNA polymerase sigma factor; Provisional; Region: PRK12542 222523002142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523002143 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523002144 DNA binding residues [nucleotide binding] 222523002145 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 222523002146 Predicted transcriptional regulator [Transcription]; Region: COG2378 222523002147 HTH domain; Region: HTH_11; pfam08279 222523002148 WYL domain; Region: WYL; pfam13280 222523002149 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 222523002150 RibD C-terminal domain; Region: RibD_C; cl17279 222523002151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523002152 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523002153 dimerization interface [polypeptide binding]; other site 222523002154 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523002155 dimer interface [polypeptide binding]; other site 222523002156 phosphorylation site [posttranslational modification] 222523002157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523002158 ATP binding site [chemical binding]; other site 222523002159 Mg2+ binding site [ion binding]; other site 222523002160 G-X-G motif; other site 222523002161 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523002162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523002163 active site 222523002164 phosphorylation site [posttranslational modification] 222523002165 intermolecular recognition site; other site 222523002166 dimerization interface [polypeptide binding]; other site 222523002167 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523002168 DNA binding site [nucleotide binding] 222523002169 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 222523002170 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 222523002171 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 222523002172 Sulfate transporter family; Region: Sulfate_transp; pfam00916 222523002173 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 222523002174 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 222523002175 Ligand Binding Site [chemical binding]; other site 222523002176 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 222523002177 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 222523002178 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 222523002179 peptide binding site [polypeptide binding]; other site 222523002180 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 222523002181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002182 dimer interface [polypeptide binding]; other site 222523002183 conserved gate region; other site 222523002184 putative PBP binding loops; other site 222523002185 ABC-ATPase subunit interface; other site 222523002186 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523002187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002188 putative PBP binding loops; other site 222523002189 ABC-ATPase subunit interface; other site 222523002190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 222523002191 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523002192 Walker A/P-loop; other site 222523002193 ATP binding site [chemical binding]; other site 222523002194 Q-loop/lid; other site 222523002195 ABC transporter signature motif; other site 222523002196 Walker B; other site 222523002197 D-loop; other site 222523002198 H-loop/switch region; other site 222523002199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 222523002200 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 222523002201 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523002202 Walker A/P-loop; other site 222523002203 ATP binding site [chemical binding]; other site 222523002204 Q-loop/lid; other site 222523002205 ABC transporter signature motif; other site 222523002206 Walker B; other site 222523002207 D-loop; other site 222523002208 H-loop/switch region; other site 222523002209 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 222523002210 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 222523002211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002212 putative substrate translocation pore; other site 222523002213 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523002214 MarR family; Region: MarR; pfam01047 222523002215 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 222523002216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002217 putative substrate translocation pore; other site 222523002218 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523002219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523002220 DNA binding site [nucleotide binding] 222523002221 domain linker motif; other site 222523002222 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 222523002223 dimerization interface [polypeptide binding]; other site 222523002224 ligand binding site [chemical binding]; other site 222523002225 sodium binding site [ion binding]; other site 222523002226 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 222523002227 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 222523002228 substrate binding site [chemical binding]; other site 222523002229 dimer interface [polypeptide binding]; other site 222523002230 ATP binding site [chemical binding]; other site 222523002231 D-ribose pyranase; Provisional; Region: PRK11797 222523002232 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 222523002233 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 222523002234 Walker A/P-loop; other site 222523002235 ATP binding site [chemical binding]; other site 222523002236 Q-loop/lid; other site 222523002237 ABC transporter signature motif; other site 222523002238 Walker B; other site 222523002239 D-loop; other site 222523002240 H-loop/switch region; other site 222523002241 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 222523002242 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 222523002243 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 222523002244 TM-ABC transporter signature motif; other site 222523002245 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 222523002246 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 222523002247 ligand binding site [chemical binding]; other site 222523002248 dimerization interface [polypeptide binding]; other site 222523002249 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 222523002250 active site 222523002251 intersubunit interactions; other site 222523002252 catalytic residue [active] 222523002253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 222523002254 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 222523002255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523002257 putative substrate translocation pore; other site 222523002258 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 222523002259 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 222523002260 putative NAD(P) binding site [chemical binding]; other site 222523002261 catalytic Zn binding site [ion binding]; other site 222523002262 Ion channel; Region: Ion_trans_2; pfam07885 222523002263 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 222523002264 Zn binding site [ion binding]; other site 222523002265 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 222523002266 putative catalytic site [active] 222523002267 metal binding site A [ion binding]; metal-binding site 222523002268 phosphate binding site [ion binding]; other site 222523002269 metal binding site C [ion binding]; metal-binding site 222523002270 metal binding site B [ion binding]; metal-binding site 222523002271 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 222523002272 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 222523002273 dimer interface [polypeptide binding]; other site 222523002274 active site 222523002275 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 222523002276 substrate binding site [chemical binding]; other site 222523002277 catalytic residue [active] 222523002278 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 222523002279 FAD binding domain; Region: FAD_binding_4; pfam01565 222523002280 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 222523002281 VanZ like family; Region: VanZ; pfam04892 222523002282 RDD family; Region: RDD; pfam06271 222523002283 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 222523002284 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523002285 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523002286 dimer interface [polypeptide binding]; other site 222523002287 putative CheW interface [polypeptide binding]; other site 222523002288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 222523002289 3D domain; Region: 3D; cl01439 222523002290 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523002291 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523002292 non-specific DNA binding site [nucleotide binding]; other site 222523002293 salt bridge; other site 222523002294 sequence-specific DNA binding site [nucleotide binding]; other site 222523002295 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 222523002296 active site 222523002297 catalytic site [active] 222523002298 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 222523002299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002300 POT family; Region: PTR2; cl17359 222523002301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002302 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 222523002303 Archaeal flagella protein; Region: Arch_fla_DE; cl01322 222523002304 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 222523002305 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 222523002306 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 222523002307 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 222523002308 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 222523002309 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523002310 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523002311 non-specific DNA binding site [nucleotide binding]; other site 222523002312 salt bridge; other site 222523002313 sequence-specific DNA binding site [nucleotide binding]; other site 222523002314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523002315 Coenzyme A binding pocket [chemical binding]; other site 222523002316 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 222523002317 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 222523002318 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 222523002319 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 222523002320 TrkA-N domain; Region: TrkA_N; pfam02254 222523002321 TrkA-C domain; Region: TrkA_C; pfam02080 222523002322 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 222523002323 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 222523002324 Subunit I/III interface [polypeptide binding]; other site 222523002325 Subunit III/IV interface [polypeptide binding]; other site 222523002326 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 222523002327 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 222523002328 D-pathway; other site 222523002329 Putative ubiquinol binding site [chemical binding]; other site 222523002330 Low-spin heme (heme b) binding site [chemical binding]; other site 222523002331 Putative water exit pathway; other site 222523002332 Binuclear center (heme o3/CuB) [ion binding]; other site 222523002333 K-pathway; other site 222523002334 Putative proton exit pathway; other site 222523002335 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 222523002336 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 222523002337 S-methylmethionine transporter; Provisional; Region: PRK11387 222523002338 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 222523002339 putative active site [active] 222523002340 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 222523002341 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 222523002342 metal binding site [ion binding]; metal-binding site 222523002343 dimer interface [polypeptide binding]; other site 222523002344 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 222523002345 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 222523002346 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 222523002347 Na binding site [ion binding]; other site 222523002348 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523002349 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 222523002350 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 222523002351 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 222523002352 FeoA domain; Region: FeoA; pfam04023 222523002353 phosphate binding protein; Region: ptsS_2; TIGR02136 222523002354 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 222523002355 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 222523002356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002357 dimer interface [polypeptide binding]; other site 222523002358 conserved gate region; other site 222523002359 putative PBP binding loops; other site 222523002360 ABC-ATPase subunit interface; other site 222523002361 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 222523002362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002363 dimer interface [polypeptide binding]; other site 222523002364 conserved gate region; other site 222523002365 putative PBP binding loops; other site 222523002366 ABC-ATPase subunit interface; other site 222523002367 AAA domain; Region: AAA_33; pfam13671 222523002368 AAA domain; Region: AAA_17; pfam13207 222523002369 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 222523002370 FOG: CBS domain [General function prediction only]; Region: COG0517 222523002371 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 222523002372 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 222523002373 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 222523002374 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523002375 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523002376 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523002377 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523002378 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523002379 Putative transcription activator [Transcription]; Region: TenA; COG0819 222523002380 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 222523002381 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 222523002382 Walker A/P-loop; other site 222523002383 ATP binding site [chemical binding]; other site 222523002384 Q-loop/lid; other site 222523002385 ABC transporter signature motif; other site 222523002386 Walker B; other site 222523002387 D-loop; other site 222523002388 H-loop/switch region; other site 222523002389 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 222523002390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002391 dimer interface [polypeptide binding]; other site 222523002392 conserved gate region; other site 222523002393 putative PBP binding loops; other site 222523002394 ABC-ATPase subunit interface; other site 222523002395 NMT1/THI5 like; Region: NMT1; pfam09084 222523002396 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 222523002397 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 222523002398 thiamine phosphate binding site [chemical binding]; other site 222523002399 active site 222523002400 pyrophosphate binding site [ion binding]; other site 222523002401 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 222523002402 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 222523002403 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 222523002404 thiS-thiF/thiG interaction site; other site 222523002405 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 222523002406 ThiS interaction site; other site 222523002407 putative active site [active] 222523002408 tetramer interface [polypeptide binding]; other site 222523002409 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 222523002410 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 222523002411 ATP binding site [chemical binding]; other site 222523002412 substrate interface [chemical binding]; other site 222523002413 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 222523002414 dimer interface [polypeptide binding]; other site 222523002415 substrate binding site [chemical binding]; other site 222523002416 ATP binding site [chemical binding]; other site 222523002417 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 222523002418 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 222523002419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523002420 Soluble P-type ATPase [General function prediction only]; Region: COG4087 222523002421 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 222523002422 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 222523002423 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 222523002424 Ligand Binding Site [chemical binding]; other site 222523002425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523002427 putative substrate translocation pore; other site 222523002428 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523002429 MarR family; Region: MarR; pfam01047 222523002430 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 222523002431 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 222523002432 active site 222523002433 nucleophile elbow; other site 222523002434 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 222523002435 short chain dehydrogenase; Provisional; Region: PRK06701 222523002436 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 222523002437 NAD binding site [chemical binding]; other site 222523002438 metal binding site [ion binding]; metal-binding site 222523002439 active site 222523002440 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 222523002441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 222523002442 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 222523002443 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523002444 catalytic residues [active] 222523002445 putative disulfide oxidoreductase; Provisional; Region: PRK03113 222523002446 YhdB-like protein; Region: YhdB; pfam14148 222523002447 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 222523002448 Spore germination protein; Region: Spore_permease; pfam03845 222523002449 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523002450 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 222523002451 putative FMN binding site [chemical binding]; other site 222523002452 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 222523002453 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 222523002454 Flagellin N-methylase; Region: FliB; pfam03692 222523002455 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 222523002456 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 222523002457 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 222523002458 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 222523002459 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 222523002460 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523002461 ATP binding site [chemical binding]; other site 222523002462 putative Mg++ binding site [ion binding]; other site 222523002463 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523002464 nucleotide binding region [chemical binding]; other site 222523002465 ATP-binding site [chemical binding]; other site 222523002466 HsdM N-terminal domain; Region: HsdM_N; pfam12161 222523002467 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 222523002468 Methyltransferase domain; Region: Methyltransf_26; pfam13659 222523002469 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 222523002470 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 222523002471 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 222523002472 Helix-turn-helix domain; Region: HTH_17; pfam12728 222523002473 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 222523002474 DHH family; Region: DHH; pfam01368 222523002475 DHHA1 domain; Region: DHHA1; pfam02272 222523002476 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523002477 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 222523002478 catalytic residues [active] 222523002479 catalytic nucleophile [active] 222523002480 Presynaptic Site I dimer interface [polypeptide binding]; other site 222523002481 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 222523002482 Synaptic Flat tetramer interface [polypeptide binding]; other site 222523002483 Recombinase; Region: Recombinase; pfam07508 222523002484 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 222523002485 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523002486 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523002487 salt bridge; other site 222523002488 non-specific DNA binding site [nucleotide binding]; other site 222523002489 sequence-specific DNA binding site [nucleotide binding]; other site 222523002490 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523002491 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523002492 catalytic residues [active] 222523002493 catalytic nucleophile [active] 222523002494 Recombinase; Region: Recombinase; pfam07508 222523002495 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523002496 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523002497 catalytic residues [active] 222523002498 catalytic nucleophile [active] 222523002499 Recombinase; Region: Recombinase; pfam07508 222523002500 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 222523002501 SpoVR like protein; Region: SpoVR; pfam04293 222523002502 Domain of unknown function (DUF1837); Region: DUF1837; pfam08878 222523002503 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523002504 ATP binding site [chemical binding]; other site 222523002505 putative Mg++ binding site [ion binding]; other site 222523002506 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523002507 nucleotide binding region [chemical binding]; other site 222523002508 ATP-binding site [chemical binding]; other site 222523002509 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 222523002510 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 222523002511 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 222523002512 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 222523002513 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 222523002514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523002515 putative DNA binding site [nucleotide binding]; other site 222523002516 putative Zn2+ binding site [ion binding]; other site 222523002517 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523002518 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 222523002519 Protein of unknown function (DUF3238); Region: DUF3238; pfam11579 222523002520 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 222523002521 putative homodimer interface [polypeptide binding]; other site 222523002522 putative homotetramer interface [polypeptide binding]; other site 222523002523 putative metal binding site [ion binding]; other site 222523002524 putative homodimer-homodimer interface [polypeptide binding]; other site 222523002525 putative allosteric switch controlling residues; other site 222523002526 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 222523002527 CPxP motif; other site 222523002528 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 222523002529 active site residue [active] 222523002530 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 222523002531 active site residue [active] 222523002532 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523002533 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 222523002534 CPxP motif; other site 222523002535 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 222523002536 active site residue [active] 222523002537 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 222523002538 active site residue [active] 222523002539 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 222523002540 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523002541 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 222523002542 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 222523002543 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 222523002544 NADP binding site [chemical binding]; other site 222523002545 dimer interface [polypeptide binding]; other site 222523002546 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 222523002547 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 222523002548 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 222523002549 PhoU domain; Region: PhoU; pfam01895 222523002550 PhoU domain; Region: PhoU; pfam01895 222523002551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523002553 putative substrate translocation pore; other site 222523002554 Uncharacterized conserved protein [Function unknown]; Region: COG3589 222523002555 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 222523002556 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 222523002557 HTH domain; Region: HTH_11; pfam08279 222523002558 Mga helix-turn-helix domain; Region: Mga; pfam05043 222523002559 PRD domain; Region: PRD; pfam00874 222523002560 PRD domain; Region: PRD; pfam00874 222523002561 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 222523002562 active site 222523002563 P-loop; other site 222523002564 phosphorylation site [posttranslational modification] 222523002565 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 222523002566 active site 222523002567 phosphorylation site [posttranslational modification] 222523002568 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 222523002569 active site 222523002570 methionine cluster; other site 222523002571 phosphorylation site [posttranslational modification] 222523002572 metal binding site [ion binding]; metal-binding site 222523002573 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 222523002574 active site 222523002575 P-loop; other site 222523002576 phosphorylation site [posttranslational modification] 222523002577 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 222523002578 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 222523002579 Uncharacterized conserved protein [Function unknown]; Region: COG3589 222523002580 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 222523002581 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523002582 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523002583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 222523002584 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 222523002585 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523002586 FtsX-like permease family; Region: FtsX; pfam02687 222523002587 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523002588 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523002589 Walker A/P-loop; other site 222523002590 ATP binding site [chemical binding]; other site 222523002591 Q-loop/lid; other site 222523002592 ABC transporter signature motif; other site 222523002593 Walker B; other site 222523002594 D-loop; other site 222523002595 H-loop/switch region; other site 222523002596 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 222523002597 HlyD family secretion protein; Region: HlyD_3; pfam13437 222523002598 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 222523002599 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 222523002600 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523002601 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523002602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002603 dimer interface [polypeptide binding]; other site 222523002604 conserved gate region; other site 222523002605 ABC-ATPase subunit interface; other site 222523002606 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 222523002607 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 222523002608 dimanganese center [ion binding]; other site 222523002609 CotJB protein; Region: CotJB; pfam12652 222523002610 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 222523002611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523002612 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523002613 active site 222523002614 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 222523002615 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 222523002616 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 222523002617 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 222523002618 putative DNA binding site [nucleotide binding]; other site 222523002619 putative homodimer interface [polypeptide binding]; other site 222523002620 Uncharacterized conserved protein [Function unknown]; Region: COG3339 222523002621 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 222523002622 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523002623 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 222523002624 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 222523002625 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 222523002626 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523002627 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 222523002628 active site 222523002629 metal binding site [ion binding]; metal-binding site 222523002630 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 222523002631 Interdomain contacts; other site 222523002632 Cytokine receptor motif; other site 222523002633 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 222523002634 amino acid transporter; Region: 2A0306; TIGR00909 222523002635 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 222523002636 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 222523002637 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 222523002638 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 222523002639 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 222523002640 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 222523002641 putative active site [active] 222523002642 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 222523002643 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 222523002644 putative active site [active] 222523002645 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 222523002646 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 222523002647 active site turn [active] 222523002648 phosphorylation site [posttranslational modification] 222523002649 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 222523002650 Uncharacterized conserved protein [Function unknown]; Region: COG3589 222523002651 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 222523002652 DoxX; Region: DoxX; pfam07681 222523002653 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 222523002654 hypothetical protein; Provisional; Region: PRK06770 222523002655 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523002656 EamA-like transporter family; Region: EamA; pfam00892 222523002657 EamA-like transporter family; Region: EamA; pfam00892 222523002658 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523002659 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 222523002660 AsnC family; Region: AsnC_trans_reg; pfam01037 222523002661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523002662 Coenzyme A binding pocket [chemical binding]; other site 222523002663 short chain dehydrogenase; Provisional; Region: PRK06924 222523002664 classical (c) SDRs; Region: SDR_c; cd05233 222523002665 NAD(P) binding site [chemical binding]; other site 222523002666 active site 222523002667 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523002668 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 222523002669 DNA binding residues [nucleotide binding] 222523002670 putative dimer interface [polypeptide binding]; other site 222523002671 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 222523002672 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 222523002673 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523002674 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523002675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523002677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002678 Predicted transcriptional regulators [Transcription]; Region: COG1733 222523002679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523002680 putative DNA binding site [nucleotide binding]; other site 222523002681 putative Zn2+ binding site [ion binding]; other site 222523002682 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 222523002683 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 222523002684 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 222523002685 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 222523002686 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 222523002687 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 222523002688 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523002689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002690 putative substrate translocation pore; other site 222523002691 intracellular protease, PfpI family; Region: PfpI; TIGR01382 222523002692 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 222523002693 proposed catalytic triad [active] 222523002694 conserved cys residue [active] 222523002695 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 222523002696 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 222523002697 Spore germination protein; Region: Spore_permease; cl17796 222523002698 glutamate racemase; Provisional; Region: PRK00865 222523002699 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 222523002700 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 222523002701 tetrameric interface [polypeptide binding]; other site 222523002702 activator binding site; other site 222523002703 NADP binding site [chemical binding]; other site 222523002704 substrate binding site [chemical binding]; other site 222523002705 catalytic residues [active] 222523002706 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523002707 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 222523002708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523002709 Walker A/P-loop; other site 222523002710 ATP binding site [chemical binding]; other site 222523002711 Q-loop/lid; other site 222523002712 ABC transporter signature motif; other site 222523002713 Walker B; other site 222523002714 D-loop; other site 222523002715 H-loop/switch region; other site 222523002716 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523002717 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 222523002718 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 222523002719 Walker A/P-loop; other site 222523002720 ATP binding site [chemical binding]; other site 222523002721 Q-loop/lid; other site 222523002722 ABC transporter signature motif; other site 222523002723 Walker B; other site 222523002724 D-loop; other site 222523002725 H-loop/switch region; other site 222523002726 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 222523002727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523002728 substrate binding pocket [chemical binding]; other site 222523002729 membrane-bound complex binding site; other site 222523002730 hinge residues; other site 222523002731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002732 dimer interface [polypeptide binding]; other site 222523002733 conserved gate region; other site 222523002734 putative PBP binding loops; other site 222523002735 ABC-ATPase subunit interface; other site 222523002736 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523002737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523002738 Walker A/P-loop; other site 222523002739 ATP binding site [chemical binding]; other site 222523002740 Q-loop/lid; other site 222523002741 ABC transporter signature motif; other site 222523002742 Walker B; other site 222523002743 D-loop; other site 222523002744 H-loop/switch region; other site 222523002745 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 222523002746 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 222523002747 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 222523002748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 222523002749 hypothetical protein; Provisional; Region: PRK13676 222523002750 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 222523002751 acetolactate synthase; Reviewed; Region: PRK08617 222523002752 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 222523002753 PYR/PP interface [polypeptide binding]; other site 222523002754 dimer interface [polypeptide binding]; other site 222523002755 TPP binding site [chemical binding]; other site 222523002756 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 222523002757 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 222523002758 TPP-binding site [chemical binding]; other site 222523002759 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 222523002760 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 222523002761 active site 222523002762 DNA binding site [nucleotide binding] 222523002763 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 222523002764 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523002765 active site 222523002766 motif I; other site 222523002767 motif II; other site 222523002768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523002769 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 222523002770 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002771 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002772 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002773 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002774 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002775 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002776 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002777 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002778 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002779 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002780 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002781 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 222523002782 amidase catalytic site [active] 222523002783 Zn binding residues [ion binding]; other site 222523002784 substrate binding site [chemical binding]; other site 222523002785 S-layer homology domain; Region: SLH; pfam00395 222523002786 S-layer homology domain; Region: SLH; pfam00395 222523002787 S-layer homology domain; Region: SLH; pfam00395 222523002788 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 222523002789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523002790 FeS/SAM binding site; other site 222523002791 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 222523002792 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 222523002793 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 222523002794 acyl-activating enzyme (AAE) consensus motif; other site 222523002795 acyl-activating enzyme (AAE) consensus motif; other site 222523002796 putative AMP binding site [chemical binding]; other site 222523002797 putative active site [active] 222523002798 putative CoA binding site [chemical binding]; other site 222523002799 Collagen binding domain; Region: Collagen_bind; pfam05737 222523002800 Cna protein B-type domain; Region: Cna_B; pfam05738 222523002801 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 222523002802 domain interaction interfaces [polypeptide binding]; other site 222523002803 high affinity sulphate transporter 1; Region: sulP; TIGR00815 222523002804 Sulfate transporter family; Region: Sulfate_transp; pfam00916 222523002805 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 222523002806 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 222523002807 ATP binding site [chemical binding]; other site 222523002808 putative Mg++ binding site [ion binding]; other site 222523002809 stage V sporulation protein B; Region: spore_V_B; TIGR02900 222523002810 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 222523002811 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 222523002812 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 222523002813 DHHW protein; Region: DHHW; pfam14286 222523002814 DHHW protein; Region: DHHW; pfam14286 222523002815 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 222523002816 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 222523002817 enoyl-CoA hydratase; Provisional; Region: PRK07659 222523002818 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 222523002819 substrate binding site [chemical binding]; other site 222523002820 oxyanion hole (OAH) forming residues; other site 222523002821 trimer interface [polypeptide binding]; other site 222523002822 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 222523002823 metal binding site [ion binding]; metal-binding site 222523002824 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 222523002825 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 222523002826 putative oligomer interface [polypeptide binding]; other site 222523002827 putative active site [active] 222523002828 metal binding site [ion binding]; metal-binding site 222523002829 S-layer homology domain; Region: SLH; pfam00395 222523002830 S-layer homology domain; Region: SLH; pfam00395 222523002831 S-layer homology domain; Region: SLH; pfam00395 222523002832 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 222523002833 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 222523002834 active site 222523002835 metal binding site [ion binding]; metal-binding site 222523002836 TIGR01177 family protein; Region: TIGR01177 222523002837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523002838 S-adenosylmethionine binding site [chemical binding]; other site 222523002839 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 222523002840 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 222523002841 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523002842 active site 222523002843 DNA binding site [nucleotide binding] 222523002844 Int/Topo IB signature motif; other site 222523002845 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 222523002846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523002847 active site 222523002848 DNA binding site [nucleotide binding] 222523002849 Int/Topo IB signature motif; other site 222523002850 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 222523002851 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 222523002852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523002853 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 222523002854 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523002855 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 222523002856 NodB motif; other site 222523002857 active site 222523002858 catalytic site [active] 222523002859 metal binding site [ion binding]; metal-binding site 222523002860 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 222523002861 proline racemase; Provisional; Region: PRK13969 222523002862 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 222523002863 ornithine cyclodeaminase; Validated; Region: PRK08618 222523002864 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 222523002865 NAD(P) binding site [chemical binding]; other site 222523002866 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 222523002867 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 222523002868 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 222523002869 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523002870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002871 dimer interface [polypeptide binding]; other site 222523002872 conserved gate region; other site 222523002873 putative PBP binding loops; other site 222523002874 ABC-ATPase subunit interface; other site 222523002875 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523002876 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 222523002877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523002878 dimer interface [polypeptide binding]; other site 222523002879 conserved gate region; other site 222523002880 putative PBP binding loops; other site 222523002881 ABC-ATPase subunit interface; other site 222523002882 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 222523002883 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523002884 Walker A/P-loop; other site 222523002885 ATP binding site [chemical binding]; other site 222523002886 Q-loop/lid; other site 222523002887 ABC transporter signature motif; other site 222523002888 Walker B; other site 222523002889 D-loop; other site 222523002890 H-loop/switch region; other site 222523002891 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 222523002892 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 222523002893 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523002894 Walker A/P-loop; other site 222523002895 ATP binding site [chemical binding]; other site 222523002896 Q-loop/lid; other site 222523002897 ABC transporter signature motif; other site 222523002898 Walker B; other site 222523002899 D-loop; other site 222523002900 H-loop/switch region; other site 222523002901 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 222523002902 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 222523002903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523002904 putative substrate translocation pore; other site 222523002905 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 222523002906 PAS domain; Region: PAS; smart00091 222523002907 putative active site [active] 222523002908 heme pocket [chemical binding]; other site 222523002909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523002910 ATP binding site [chemical binding]; other site 222523002911 Mg2+ binding site [ion binding]; other site 222523002912 G-X-G motif; other site 222523002913 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 222523002914 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523002915 active site 222523002916 phosphorylation site [posttranslational modification] 222523002917 intermolecular recognition site; other site 222523002918 dimerization interface [polypeptide binding]; other site 222523002919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 222523002920 Nuclease-related domain; Region: NERD; pfam08378 222523002921 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 222523002922 Family description; Region: UvrD_C_2; pfam13538 222523002923 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 222523002924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 222523002925 Protein of unknown function (DUF524); Region: DUF524; pfam04411 222523002926 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 222523002927 DNA methylase; Region: N6_N4_Mtase; cl17433 222523002928 DNA methylase; Region: N6_N4_Mtase; pfam01555 222523002929 type III restriction-modification system StyLTI enzyme res; Provisional; Region: PRK15483 222523002930 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 222523002931 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 222523002932 VRR-NUC domain; Region: VRR_NUC; pfam08774 222523002933 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 222523002934 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523002935 ATP binding site [chemical binding]; other site 222523002936 putative Mg++ binding site [ion binding]; other site 222523002937 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523002938 nucleotide binding region [chemical binding]; other site 222523002939 ATP-binding site [chemical binding]; other site 222523002940 HEAT repeats; Region: HEAT_2; pfam13646 222523002941 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 222523002942 metal binding site [ion binding]; metal-binding site 222523002943 ParB-like nuclease domain; Region: ParB; smart00470 222523002944 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 222523002945 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 222523002946 replicative DNA helicase; Provisional; Region: PRK06749 222523002947 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 222523002948 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 222523002949 Walker A motif; other site 222523002950 ATP binding site [chemical binding]; other site 222523002951 Walker B motif; other site 222523002952 DNA binding loops [nucleotide binding] 222523002953 Predicted transcriptional regulators [Transcription]; Region: COG1378 222523002954 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 222523002955 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 222523002956 C-terminal domain interface [polypeptide binding]; other site 222523002957 sugar binding site [chemical binding]; other site 222523002958 hypothetical protein; Provisional; Region: PRK10621 222523002959 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523002960 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523002961 EamA-like transporter family; Region: EamA; pfam00892 222523002962 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 222523002963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523002964 YmzC-like protein; Region: YmzC; pfam14157 222523002965 Domain of unknown function (DUF4259); Region: DUF4259; pfam14078 222523002966 Transcriptional regulators [Transcription]; Region: MarR; COG1846 222523002967 MarR family; Region: MarR_2; pfam12802 222523002968 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 222523002969 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 222523002970 ATP synthase I chain; Region: ATP_synt_I; pfam03899 222523002971 VanZ like family; Region: VanZ; pfam04892 222523002972 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 222523002973 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 222523002974 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 222523002975 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 222523002976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523002977 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 222523002978 dihydroxyacetone kinase; Provisional; Region: PRK14479 222523002979 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 222523002980 DAK2 domain; Region: Dak2; pfam02734 222523002981 Bacterial SH3 domain; Region: SH3_3; cl17532 222523002982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523002983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 222523002984 TPR motif; other site 222523002985 binding surface 222523002986 Short C-terminal domain; Region: SHOCT; pfam09851 222523002987 CAAX protease self-immunity; Region: Abi; pfam02517 222523002988 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523002989 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523002990 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 222523002991 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 222523002992 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 222523002993 active site 222523002994 dimer interface [polypeptide binding]; other site 222523002995 non-prolyl cis peptide bond; other site 222523002996 insertion regions; other site 222523002997 ATP-grasp domain; Region: ATP-grasp_4; cl17255 222523002998 DAK2 domain; Region: Dak2; cl03685 222523002999 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 222523003000 Predicted transcriptional regulator [Transcription]; Region: COG1959 222523003001 Transcriptional regulator; Region: Rrf2; pfam02082 222523003002 S-layer homology domain; Region: SLH; pfam00395 222523003003 S-layer homology domain; Region: SLH; pfam00395 222523003004 S-layer homology domain; Region: SLH; pfam00395 222523003005 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 222523003006 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523003007 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523003008 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 222523003009 S-layer homology domain; Region: SLH; pfam00395 222523003010 S-layer homology domain; Region: SLH; pfam00395 222523003011 S-layer homology domain; Region: SLH; pfam00395 222523003012 hypothetical protein; Provisional; Region: PRK06770 222523003013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523003014 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523003015 active site 222523003016 Heat induced stress protein YflT; Region: YflT; pfam11181 222523003017 CsbD-like; Region: CsbD; pfam05532 222523003018 Predicted membrane protein [Function unknown]; Region: COG2261 222523003019 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 222523003020 anti sigma factor interaction site; other site 222523003021 regulatory phosphorylation site [posttranslational modification]; other site 222523003022 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 222523003023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523003024 ATP binding site [chemical binding]; other site 222523003025 Mg2+ binding site [ion binding]; other site 222523003026 G-X-G motif; other site 222523003027 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 222523003028 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523003029 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 222523003030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523003031 DNA binding residues [nucleotide binding] 222523003032 Ferritin-like domain; Region: Ferritin; pfam00210 222523003033 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 222523003034 dinuclear metal binding motif [ion binding]; other site 222523003035 Response regulator receiver domain; Region: Response_reg; pfam00072 222523003036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523003037 active site 222523003038 phosphorylation site [posttranslational modification] 222523003039 intermolecular recognition site; other site 222523003040 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 222523003041 dimerization interface [polypeptide binding]; other site 222523003042 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 222523003043 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 222523003044 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 222523003045 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 222523003046 CHASE3 domain; Region: CHASE3; pfam05227 222523003047 GAF domain; Region: GAF; pfam01590 222523003048 GAF domain; Region: GAF_2; pfam13185 222523003049 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523003050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523003051 dimer interface [polypeptide binding]; other site 222523003052 phosphorylation site [posttranslational modification] 222523003053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523003054 ATP binding site [chemical binding]; other site 222523003055 Mg2+ binding site [ion binding]; other site 222523003056 G-X-G motif; other site 222523003057 Response regulator receiver domain; Region: Response_reg; pfam00072 222523003058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523003059 active site 222523003060 phosphorylation site [posttranslational modification] 222523003061 intermolecular recognition site; other site 222523003062 dimerization interface [polypeptide binding]; other site 222523003063 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 222523003064 hypothetical protein; Provisional; Region: PRK12856 222523003065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523003066 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 222523003067 Probable transposase; Region: OrfB_IS605; pfam01385 222523003068 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523003069 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 222523003070 NADP binding site [chemical binding]; other site 222523003071 dimer interface [polypeptide binding]; other site 222523003072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523003073 Histidine kinase; Region: HisKA_3; pfam07730 222523003074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523003075 ATP binding site [chemical binding]; other site 222523003076 Mg2+ binding site [ion binding]; other site 222523003077 G-X-G motif; other site 222523003078 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523003079 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523003080 active site 222523003081 phosphorylation site [posttranslational modification] 222523003082 intermolecular recognition site; other site 222523003083 dimerization interface [polypeptide binding]; other site 222523003084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523003085 DNA binding residues [nucleotide binding] 222523003086 dimerization interface [polypeptide binding]; other site 222523003087 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 222523003088 YhzD-like protein; Region: YhzD; pfam14120 222523003089 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 222523003090 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523003091 active site 222523003092 metal binding site [ion binding]; metal-binding site 222523003093 DNA binding site [nucleotide binding] 222523003094 AAA domain; Region: AAA_27; pfam13514 222523003095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523003096 Q-loop/lid; other site 222523003097 ABC transporter signature motif; other site 222523003098 Walker B; other site 222523003099 D-loop; other site 222523003100 H-loop/switch region; other site 222523003101 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 222523003102 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 222523003103 generic binding surface I; other site 222523003104 generic binding surface II; other site 222523003105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523003106 Zn2+ binding site [ion binding]; other site 222523003107 Mg2+ binding site [ion binding]; other site 222523003108 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 222523003109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523003110 Zn binding site [ion binding]; other site 222523003111 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 222523003112 Zn binding site [ion binding]; other site 222523003113 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 222523003114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523003115 Zn binding site [ion binding]; other site 222523003116 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 222523003117 Zn binding site [ion binding]; other site 222523003118 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; pfam09965 222523003119 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 222523003120 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523003121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523003122 DNA binding residues [nucleotide binding] 222523003123 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 222523003124 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523003125 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 222523003126 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 222523003127 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 222523003128 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 222523003129 amphipathic channel; other site 222523003130 Asn-Pro-Ala signature motifs; other site 222523003131 glycerol kinase; Provisional; Region: glpK; PRK00047 222523003132 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 222523003133 N- and C-terminal domain interface [polypeptide binding]; other site 222523003134 active site 222523003135 MgATP binding site [chemical binding]; other site 222523003136 catalytic site [active] 222523003137 metal binding site [ion binding]; metal-binding site 222523003138 glycerol binding site [chemical binding]; other site 222523003139 homotetramer interface [polypeptide binding]; other site 222523003140 homodimer interface [polypeptide binding]; other site 222523003141 FBP binding site [chemical binding]; other site 222523003142 protein IIAGlc interface [polypeptide binding]; other site 222523003143 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 222523003144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 222523003145 Helix-turn-helix domain; Region: HTH_28; pfam13518 222523003146 Helix-turn-helix domain; Region: HTH_28; pfam13518 222523003147 putative transposase OrfB; Reviewed; Region: PHA02517 222523003148 HTH-like domain; Region: HTH_21; pfam13276 222523003149 Integrase core domain; Region: rve; pfam00665 222523003150 Integrase core domain; Region: rve_2; pfam13333 222523003151 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 222523003152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523003153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523003154 DNA binding residues [nucleotide binding] 222523003155 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 222523003156 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523003157 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 222523003158 Family description; Region: UvrD_C_2; pfam13538 222523003159 Domain of unknown function DUF87; Region: DUF87; pfam01935 222523003160 AAA-like domain; Region: AAA_10; pfam12846 222523003161 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 222523003162 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 222523003163 nucleotide binding site [chemical binding]; other site 222523003164 putative NEF/HSP70 interaction site [polypeptide binding]; other site 222523003165 SBD interface [polypeptide binding]; other site 222523003166 DnaJ domain; Region: DnaJ; pfam00226 222523003167 TPR repeat; Region: TPR_11; pfam13414 222523003168 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523003169 TPR motif; other site 222523003170 binding surface 222523003171 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523003172 binding surface 222523003173 TPR motif; other site 222523003174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523003175 binding surface 222523003176 Tetratricopeptide repeat; Region: TPR_16; pfam13432 222523003177 TPR motif; other site 222523003178 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523003179 binding surface 222523003180 Tetratricopeptide repeat; Region: TPR_16; pfam13432 222523003181 TPR motif; other site 222523003182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 222523003183 stage V sporulation protein K; Region: spore_V_K; TIGR02881 222523003184 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003185 Walker A motif; other site 222523003186 ATP binding site [chemical binding]; other site 222523003187 Walker B motif; other site 222523003188 arginine finger; other site 222523003189 stage V sporulation protein K; Region: spore_V_K; TIGR02881 222523003190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003191 Walker A motif; other site 222523003192 ATP binding site [chemical binding]; other site 222523003193 Walker B motif; other site 222523003194 arginine finger; other site 222523003195 stage V sporulation protein K; Region: spore_V_K; TIGR02881 222523003196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003197 Walker A motif; other site 222523003198 ATP binding site [chemical binding]; other site 222523003199 Walker B motif; other site 222523003200 arginine finger; other site 222523003201 stage V sporulation protein K; Region: spore_V_K; TIGR02881 222523003202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003203 Walker A motif; other site 222523003204 ATP binding site [chemical binding]; other site 222523003205 Walker B motif; other site 222523003206 arginine finger; other site 222523003207 stage V sporulation protein K; Region: spore_V_K; TIGR02881 222523003208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003209 Walker A motif; other site 222523003210 ATP binding site [chemical binding]; other site 222523003211 Walker B motif; other site 222523003212 arginine finger; other site 222523003213 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 222523003214 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 222523003215 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 222523003216 transcriptional regulator Hpr; Provisional; Region: PRK13777 222523003217 MarR family; Region: MarR; pfam01047 222523003218 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 222523003219 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 222523003220 HIT family signature motif; other site 222523003221 catalytic residue [active] 222523003222 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 222523003223 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523003224 Walker A/P-loop; other site 222523003225 ATP binding site [chemical binding]; other site 222523003226 Q-loop/lid; other site 222523003227 ABC transporter signature motif; other site 222523003228 Walker B; other site 222523003229 D-loop; other site 222523003230 H-loop/switch region; other site 222523003231 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 222523003232 EcsC protein family; Region: EcsC; pfam12787 222523003233 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523003234 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523003235 Uncharacterized conserved protein [Function unknown]; Region: COG3402 222523003236 Predicted membrane protein [Function unknown]; Region: COG3428 222523003237 Bacterial PH domain; Region: DUF304; pfam03703 222523003238 Bacterial PH domain; Region: DUF304; cl01348 222523003239 Bacterial PH domain; Region: DUF304; pfam03703 222523003240 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 222523003241 MAEBL; Provisional; Region: PTZ00121 222523003242 Uncharacterized conserved protein [Function unknown]; Region: COG3402 222523003243 Predicted membrane protein [Function unknown]; Region: COG3428 222523003244 Bacterial PH domain; Region: DUF304; pfam03703 222523003245 Bacterial PH domain; Region: DUF304; pfam03703 222523003246 Bacterial PH domain; Region: DUF304; pfam03703 222523003247 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 222523003248 Transglycosylase; Region: Transgly; pfam00912 222523003249 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 222523003250 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523003251 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 222523003252 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 222523003253 substrate binding site [chemical binding]; other site 222523003254 active site 222523003255 ferrochelatase; Provisional; Region: PRK12435 222523003256 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 222523003257 C-terminal domain interface [polypeptide binding]; other site 222523003258 active site 222523003259 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 222523003260 active site 222523003261 N-terminal domain interface [polypeptide binding]; other site 222523003262 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 222523003263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523003264 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 222523003265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 222523003266 Fn3 associated; Region: Fn3_assoc; pfam13287 222523003267 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 222523003268 generic binding surface II; other site 222523003269 generic binding surface I; other site 222523003270 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 222523003271 putative active site [active] 222523003272 putative catalytic site [active] 222523003273 putative Mg binding site IVb [ion binding]; other site 222523003274 putative phosphate binding site [ion binding]; other site 222523003275 putative DNA binding site [nucleotide binding]; other site 222523003276 putative Mg binding site IVa [ion binding]; other site 222523003277 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523003278 Penicillinase repressor; Region: Pencillinase_R; pfam03965 222523003279 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 222523003280 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523003281 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523003282 Predicted membrane protein [Function unknown]; Region: COG1511 222523003283 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 222523003284 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 222523003285 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 222523003286 Domain of unknown function (DUF3508); Region: DUF3508; pfam12018 222523003287 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 222523003288 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 222523003289 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 222523003290 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 222523003291 Yip1 domain; Region: Yip1; pfam04893 222523003292 DinB superfamily; Region: DinB_2; pfam12867 222523003293 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 222523003294 Predicted transcriptional regulator [Transcription]; Region: COG2378 222523003295 HTH domain; Region: HTH_11; pfam08279 222523003296 WYL domain; Region: WYL; pfam13280 222523003297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523003298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523003299 DNA binding site [nucleotide binding] 222523003300 domain linker motif; other site 222523003301 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 222523003302 putative dimerization interface [polypeptide binding]; other site 222523003303 putative ligand binding site [chemical binding]; other site 222523003304 YhfH-like protein; Region: YhfH; pfam14149 222523003305 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 222523003306 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 222523003307 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 222523003308 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 222523003309 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 222523003310 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 222523003311 acyl-activating enzyme (AAE) consensus motif; other site 222523003312 putative AMP binding site [chemical binding]; other site 222523003313 putative active site [active] 222523003314 putative CoA binding site [chemical binding]; other site 222523003315 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523003316 heme-binding site [chemical binding]; other site 222523003317 S-layer homology domain; Region: SLH; pfam00395 222523003318 S-layer homology domain; Region: SLH; pfam00395 222523003319 S-layer homology domain; Region: SLH; pfam00395 222523003320 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 222523003321 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523003322 substrate binding pocket [chemical binding]; other site 222523003323 membrane-bound complex binding site; other site 222523003324 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 222523003325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003326 dimer interface [polypeptide binding]; other site 222523003327 conserved gate region; other site 222523003328 putative PBP binding loops; other site 222523003329 ABC-ATPase subunit interface; other site 222523003330 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 222523003331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003332 dimer interface [polypeptide binding]; other site 222523003333 conserved gate region; other site 222523003334 putative PBP binding loops; other site 222523003335 ABC-ATPase subunit interface; other site 222523003336 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 222523003337 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 222523003338 Walker A/P-loop; other site 222523003339 ATP binding site [chemical binding]; other site 222523003340 Q-loop/lid; other site 222523003341 ABC transporter signature motif; other site 222523003342 Walker B; other site 222523003343 D-loop; other site 222523003344 H-loop/switch region; other site 222523003345 TOBE-like domain; Region: TOBE_3; pfam12857 222523003346 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 222523003347 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 222523003348 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 222523003349 RHS Repeat; Region: RHS_repeat; pfam05593 222523003350 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 222523003351 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 222523003352 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 222523003353 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 222523003354 RHS protein; Region: RHS; pfam03527 222523003355 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 222523003356 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 222523003357 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 222523003358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523003359 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523003360 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523003361 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 222523003362 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 222523003363 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523003364 putative active site [active] 222523003365 putative metal binding site [ion binding]; other site 222523003366 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523003367 Zn2+ binding site [ion binding]; other site 222523003368 Mg2+ binding site [ion binding]; other site 222523003369 Putative zinc-finger; Region: zf-HC2; pfam13490 222523003370 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 222523003371 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 222523003372 RNA polymerase sigma factor; Provisional; Region: PRK12541 222523003373 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523003374 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523003375 DNA binding residues [nucleotide binding] 222523003376 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523003377 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 222523003378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523003379 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 222523003380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523003381 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523003382 dimer interface [polypeptide binding]; other site 222523003383 phosphorylation site [posttranslational modification] 222523003384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523003385 ATP binding site [chemical binding]; other site 222523003386 Mg2+ binding site [ion binding]; other site 222523003387 G-X-G motif; other site 222523003388 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523003389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523003390 active site 222523003391 phosphorylation site [posttranslational modification] 222523003392 intermolecular recognition site; other site 222523003393 dimerization interface [polypeptide binding]; other site 222523003394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523003395 DNA binding site [nucleotide binding] 222523003396 CAAX protease self-immunity; Region: Abi; pfam02517 222523003397 Peptidase family M48; Region: Peptidase_M48; pfam01435 222523003398 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523003399 EamA-like transporter family; Region: EamA; pfam00892 222523003400 EamA-like transporter family; Region: EamA; pfam00892 222523003401 S-layer homology domain; Region: SLH; pfam00395 222523003402 S-layer homology domain; Region: SLH; pfam00395 222523003403 S-layer homology domain; Region: SLH; pfam00395 222523003404 S-layer homology domain; Region: SLH; pfam00395 222523003405 S-layer homology domain; Region: SLH; pfam00395 222523003406 S-layer homology domain; Region: SLH; pfam00395 222523003407 S-layer homology domain; Region: SLH; pfam00395 222523003408 S-layer homology domain; Region: SLH; pfam00395 222523003409 S-layer homology domain; Region: SLH; pfam00395 222523003410 malate synthase A; Region: malate_syn_A; TIGR01344 222523003411 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 222523003412 active site 222523003413 isocitrate lyase; Provisional; Region: PRK15063 222523003414 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 222523003415 tetramer interface [polypeptide binding]; other site 222523003416 active site 222523003417 Mg2+/Mn2+ binding site [ion binding]; other site 222523003418 Phosphotransferase enzyme family; Region: APH; pfam01636 222523003419 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523003420 active site 222523003421 substrate binding site [chemical binding]; other site 222523003422 ATP binding site [chemical binding]; other site 222523003423 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 222523003424 DNA-binding site [nucleotide binding]; DNA binding site 222523003425 RNA-binding motif; other site 222523003426 ComK protein; Region: ComK; pfam06338 222523003427 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523003428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523003429 active site 222523003430 phosphorylation site [posttranslational modification] 222523003431 intermolecular recognition site; other site 222523003432 dimerization interface [polypeptide binding]; other site 222523003433 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523003434 DNA binding residues [nucleotide binding] 222523003435 dimerization interface [polypeptide binding]; other site 222523003436 Uncharacterized conserved protein [Function unknown]; Region: COG0398 222523003437 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523003438 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 222523003439 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523003440 Catalytic site [active] 222523003441 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523003442 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 222523003443 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 222523003444 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 222523003445 Part of AAA domain; Region: AAA_19; pfam13245 222523003446 Family description; Region: UvrD_C_2; pfam13538 222523003447 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 222523003448 hypothetical protein; Provisional; Region: PRK07758 222523003449 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523003450 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 222523003451 Spore germination protein GerPC; Region: GerPC; pfam10737 222523003452 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 222523003453 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523003454 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 222523003455 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 222523003456 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 222523003457 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 222523003458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523003459 inhibitor-cofactor binding pocket; inhibition site 222523003460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523003461 catalytic residue [active] 222523003462 hypothetical protein; Provisional; Region: PRK13673 222523003463 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 222523003464 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 222523003465 active site 222523003466 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 222523003467 dimer interface [polypeptide binding]; other site 222523003468 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 222523003469 Ligand Binding Site [chemical binding]; other site 222523003470 Molecular Tunnel; other site 222523003471 ferrochelatase; Provisional; Region: PRK12435 222523003472 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 222523003473 C-terminal domain interface [polypeptide binding]; other site 222523003474 active site 222523003475 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 222523003476 active site 222523003477 N-terminal domain interface [polypeptide binding]; other site 222523003478 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 222523003479 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 222523003480 tetramer interface [polypeptide binding]; other site 222523003481 heme binding pocket [chemical binding]; other site 222523003482 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523003483 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 222523003484 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 222523003485 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523003486 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 222523003487 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523003488 motif II; other site 222523003489 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 222523003490 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 222523003491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523003492 sequence-specific DNA binding site [nucleotide binding]; other site 222523003493 salt bridge; other site 222523003494 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 222523003495 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 222523003496 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 222523003497 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 222523003498 active site 222523003499 catalytic site [active] 222523003500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523003501 non-specific DNA binding site [nucleotide binding]; other site 222523003502 salt bridge; other site 222523003503 sequence-specific DNA binding site [nucleotide binding]; other site 222523003504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 222523003505 binding surface 222523003506 TPR motif; other site 222523003507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523003508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 222523003509 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 222523003510 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 222523003511 S1 domain; Region: S1_2; pfam13509 222523003512 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 222523003513 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 222523003514 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 222523003515 RHS Repeat; Region: RHS_repeat; pfam05593 222523003516 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 222523003517 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 222523003518 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 222523003519 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 222523003520 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 222523003521 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 222523003522 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523003523 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523003524 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523003525 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523003526 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 222523003527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523003528 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523003529 active site 222523003530 motif I; other site 222523003531 motif II; other site 222523003532 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 222523003533 YjzC-like protein; Region: YjzC; pfam14168 222523003534 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 222523003535 Clp amino terminal domain; Region: Clp_N; pfam02861 222523003536 Clp amino terminal domain; Region: Clp_N; pfam02861 222523003537 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003538 Walker A motif; other site 222523003539 ATP binding site [chemical binding]; other site 222523003540 Walker B motif; other site 222523003541 arginine finger; other site 222523003542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523003543 Walker A motif; other site 222523003544 ATP binding site [chemical binding]; other site 222523003545 Walker B motif; other site 222523003546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 222523003547 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 222523003548 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 222523003549 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 222523003550 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 222523003551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523003552 NAD(P) binding site [chemical binding]; other site 222523003553 active site 222523003554 ComZ; Region: ComZ; pfam10815 222523003555 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 222523003556 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 222523003557 dimer interface [polypeptide binding]; other site 222523003558 active site 222523003559 CoA binding pocket [chemical binding]; other site 222523003560 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 222523003561 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 222523003562 dimer interface [polypeptide binding]; other site 222523003563 active site 222523003564 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 222523003565 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 222523003566 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 222523003567 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 222523003568 active site 222523003569 HIGH motif; other site 222523003570 dimer interface [polypeptide binding]; other site 222523003571 KMSKS motif; other site 222523003572 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 222523003573 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523003574 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523003575 peptide binding site [polypeptide binding]; other site 222523003576 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523003577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003578 dimer interface [polypeptide binding]; other site 222523003579 conserved gate region; other site 222523003580 putative PBP binding loops; other site 222523003581 ABC-ATPase subunit interface; other site 222523003582 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523003583 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 222523003584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003585 dimer interface [polypeptide binding]; other site 222523003586 conserved gate region; other site 222523003587 putative PBP binding loops; other site 222523003588 ABC-ATPase subunit interface; other site 222523003589 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 222523003590 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523003591 Walker A/P-loop; other site 222523003592 ATP binding site [chemical binding]; other site 222523003593 Q-loop/lid; other site 222523003594 ABC transporter signature motif; other site 222523003595 Walker B; other site 222523003596 D-loop; other site 222523003597 H-loop/switch region; other site 222523003598 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 222523003599 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 222523003600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 222523003601 Walker A/P-loop; other site 222523003602 ATP binding site [chemical binding]; other site 222523003603 Q-loop/lid; other site 222523003604 ABC transporter signature motif; other site 222523003605 Walker B; other site 222523003606 D-loop; other site 222523003607 H-loop/switch region; other site 222523003608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 222523003609 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 222523003610 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 222523003611 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523003612 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523003613 peptide binding site [polypeptide binding]; other site 222523003614 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 222523003615 ArsC family; Region: ArsC; pfam03960 222523003616 putative catalytic residues [active] 222523003617 thiol/disulfide switch; other site 222523003618 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 222523003619 adaptor protein; Provisional; Region: PRK02315 222523003620 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 222523003621 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 222523003622 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 222523003623 putative active site [active] 222523003624 catalytic site [active] 222523003625 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 222523003626 putative active site [active] 222523003627 catalytic site [active] 222523003628 Competence protein CoiA-like family; Region: CoiA; cl11541 222523003629 oligoendopeptidase F; Region: pepF; TIGR00181 222523003630 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 222523003631 active site 222523003632 Zn binding site [ion binding]; other site 222523003633 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 222523003634 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 222523003635 catalytic residues [active] 222523003636 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 222523003637 apolar tunnel; other site 222523003638 heme binding site [chemical binding]; other site 222523003639 dimerization interface [polypeptide binding]; other site 222523003640 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 222523003641 putative active site [active] 222523003642 putative metal binding residues [ion binding]; other site 222523003643 signature motif; other site 222523003644 putative triphosphate binding site [ion binding]; other site 222523003645 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 222523003646 synthetase active site [active] 222523003647 NTP binding site [chemical binding]; other site 222523003648 metal binding site [ion binding]; metal-binding site 222523003649 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 222523003650 ATP-NAD kinase; Region: NAD_kinase; pfam01513 222523003651 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 222523003652 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 222523003653 active site 222523003654 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 222523003655 trimer interface [polypeptide binding]; other site 222523003656 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 222523003657 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 222523003658 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 222523003659 active site 222523003660 metal binding site [ion binding]; metal-binding site 222523003661 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 222523003662 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 222523003663 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 222523003664 active site 222523003665 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523003666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523003667 S-adenosylmethionine binding site [chemical binding]; other site 222523003668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 222523003669 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 222523003670 putative metal binding site; other site 222523003671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523003672 binding surface 222523003673 TPR motif; other site 222523003674 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 222523003675 binding surface 222523003676 TPR motif; other site 222523003677 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523003678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523003679 S-adenosylmethionine binding site [chemical binding]; other site 222523003680 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 222523003681 catalytic residues [active] 222523003682 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 222523003683 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 222523003684 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523003685 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 222523003686 active site 222523003687 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 222523003688 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 222523003689 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 222523003690 NAD binding site [chemical binding]; other site 222523003691 substrate binding site [chemical binding]; other site 222523003692 homodimer interface [polypeptide binding]; other site 222523003693 active site 222523003694 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 222523003695 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 222523003696 NADP binding site [chemical binding]; other site 222523003697 active site 222523003698 putative substrate binding site [chemical binding]; other site 222523003699 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 222523003700 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 222523003701 NAD binding site [chemical binding]; other site 222523003702 homotetramer interface [polypeptide binding]; other site 222523003703 homodimer interface [polypeptide binding]; other site 222523003704 substrate binding site [chemical binding]; other site 222523003705 active site 222523003706 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 222523003707 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 222523003708 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 222523003709 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 222523003710 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 222523003711 Part of AAA domain; Region: AAA_19; pfam13245 222523003712 Family description; Region: UvrD_C_2; pfam13538 222523003713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 222523003714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523003715 Coenzyme A binding pocket [chemical binding]; other site 222523003716 hypothetical protein; Provisional; Region: PRK13679 222523003717 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 222523003718 Putative esterase; Region: Esterase; pfam00756 222523003719 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 222523003720 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523003721 EamA-like transporter family; Region: EamA; pfam00892 222523003722 EamA-like transporter family; Region: EamA; pfam00892 222523003723 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 222523003724 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 222523003725 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 222523003726 Na binding site [ion binding]; other site 222523003727 anthranilate synthase component I; Provisional; Region: PRK13570 222523003728 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 222523003729 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 222523003730 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 222523003731 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 222523003732 glutamine binding [chemical binding]; other site 222523003733 catalytic triad [active] 222523003734 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 222523003735 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 222523003736 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 222523003737 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 222523003738 active site 222523003739 ribulose/triose binding site [chemical binding]; other site 222523003740 phosphate binding site [ion binding]; other site 222523003741 substrate (anthranilate) binding pocket [chemical binding]; other site 222523003742 product (indole) binding pocket [chemical binding]; other site 222523003743 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 222523003744 active site 222523003745 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 222523003746 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 222523003747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523003748 catalytic residue [active] 222523003749 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 222523003750 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 222523003751 substrate binding site [chemical binding]; other site 222523003752 active site 222523003753 catalytic residues [active] 222523003754 heterodimer interface [polypeptide binding]; other site 222523003755 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 222523003756 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 222523003757 L-lactate permease; Region: Lactate_perm; cl00701 222523003758 Probable transposase; Region: OrfB_IS605; pfam01385 222523003759 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 222523003760 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 222523003761 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 222523003762 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 222523003763 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 222523003764 Double zinc ribbon; Region: DZR; pfam12773 222523003765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523003766 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 222523003767 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523003768 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 222523003769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523003770 Coenzyme A binding pocket [chemical binding]; other site 222523003771 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 222523003772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523003773 S-adenosylmethionine binding site [chemical binding]; other site 222523003774 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 222523003775 NADPH bind site [chemical binding]; other site 222523003776 putative FMN binding site [chemical binding]; other site 222523003777 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 222523003778 putative FMN binding site [chemical binding]; other site 222523003779 NADPH bind site [chemical binding]; other site 222523003780 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 222523003781 YcaO-like family; Region: YcaO; pfam02624 222523003782 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 222523003783 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 222523003784 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 222523003785 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 222523003786 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 222523003787 E3 interaction surface; other site 222523003788 lipoyl attachment site [posttranslational modification]; other site 222523003789 e3 binding domain; Region: E3_binding; pfam02817 222523003790 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 222523003791 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 222523003792 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 222523003793 TPP-binding site [chemical binding]; other site 222523003794 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 222523003795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523003796 salt bridge; other site 222523003797 non-specific DNA binding site [nucleotide binding]; other site 222523003798 sequence-specific DNA binding site [nucleotide binding]; other site 222523003799 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 222523003800 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 222523003801 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523003802 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 222523003803 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 222523003804 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523003805 Catalytic site [active] 222523003806 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 222523003807 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 222523003808 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 222523003809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523003810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523003811 non-specific DNA binding site [nucleotide binding]; other site 222523003812 salt bridge; other site 222523003813 sequence-specific DNA binding site [nucleotide binding]; other site 222523003814 Anti-repressor SinI; Region: SinI; pfam08671 222523003815 Anti-repressor SinI; Region: SinI; pfam08671 222523003816 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 222523003817 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 222523003818 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 222523003819 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 222523003820 NAD(P) binding site [chemical binding]; other site 222523003821 catalytic residues [active] 222523003822 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 222523003823 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 222523003824 Walker A/P-loop; other site 222523003825 ATP binding site [chemical binding]; other site 222523003826 Q-loop/lid; other site 222523003827 ABC transporter signature motif; other site 222523003828 Walker B; other site 222523003829 D-loop; other site 222523003830 H-loop/switch region; other site 222523003831 TOBE domain; Region: TOBE_2; pfam08402 222523003832 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 222523003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003834 dimer interface [polypeptide binding]; other site 222523003835 conserved gate region; other site 222523003836 putative PBP binding loops; other site 222523003837 ABC-ATPase subunit interface; other site 222523003838 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 222523003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003840 dimer interface [polypeptide binding]; other site 222523003841 conserved gate region; other site 222523003842 putative PBP binding loops; other site 222523003843 ABC-ATPase subunit interface; other site 222523003844 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 222523003845 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 222523003846 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 222523003847 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 222523003848 active site 222523003849 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 222523003850 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 222523003851 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 222523003852 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 222523003853 active site 222523003854 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 222523003855 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 222523003856 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 222523003857 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 222523003858 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 222523003859 Cysteine-rich domain; Region: CCG; pfam02754 222523003860 Cysteine-rich domain; Region: CCG; pfam02754 222523003861 FAD binding domain; Region: FAD_binding_4; pfam01565 222523003862 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 222523003863 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 222523003864 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 222523003865 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 222523003866 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523003867 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523003868 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523003869 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523003870 active site 222523003871 phosphorylation site [posttranslational modification] 222523003872 intermolecular recognition site; other site 222523003873 dimerization interface [polypeptide binding]; other site 222523003874 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523003875 DNA binding site [nucleotide binding] 222523003876 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 222523003877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523003878 dimerization interface [polypeptide binding]; other site 222523003879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523003880 dimer interface [polypeptide binding]; other site 222523003881 phosphorylation site [posttranslational modification] 222523003882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523003883 ATP binding site [chemical binding]; other site 222523003884 Mg2+ binding site [ion binding]; other site 222523003885 G-X-G motif; other site 222523003886 Transcriptional regulators [Transcription]; Region: FadR; COG2186 222523003887 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523003888 DNA-binding site [nucleotide binding]; DNA binding site 222523003889 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 222523003890 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 222523003891 Cysteine-rich domain; Region: CCG; pfam02754 222523003892 Cysteine-rich domain; Region: CCG; pfam02754 222523003893 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 222523003894 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 222523003895 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 222523003896 Uncharacterized conserved protein [Function unknown]; Region: COG1556 222523003897 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 222523003898 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 222523003899 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 222523003900 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 222523003901 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 222523003902 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 222523003903 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 222523003904 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 222523003905 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 222523003906 dimer interaction site [polypeptide binding]; other site 222523003907 substrate-binding tunnel; other site 222523003908 active site 222523003909 catalytic site [active] 222523003910 substrate binding site [chemical binding]; other site 222523003911 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 222523003912 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 222523003913 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523003914 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 222523003915 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 222523003916 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 222523003917 NAD(P) binding site [chemical binding]; other site 222523003918 homotetramer interface [polypeptide binding]; other site 222523003919 homodimer interface [polypeptide binding]; other site 222523003920 active site 222523003921 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 222523003922 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 222523003923 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 222523003924 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 222523003925 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 222523003926 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 222523003927 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 222523003928 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 222523003929 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 222523003930 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 222523003931 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 222523003932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523003933 Walker A/P-loop; other site 222523003934 ATP binding site [chemical binding]; other site 222523003935 Q-loop/lid; other site 222523003936 ABC transporter signature motif; other site 222523003937 Walker B; other site 222523003938 D-loop; other site 222523003939 H-loop/switch region; other site 222523003940 TOBE domain; Region: TOBE_2; pfam08402 222523003941 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 222523003942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003943 dimer interface [polypeptide binding]; other site 222523003944 conserved gate region; other site 222523003945 putative PBP binding loops; other site 222523003946 ABC-ATPase subunit interface; other site 222523003947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523003948 dimer interface [polypeptide binding]; other site 222523003949 conserved gate region; other site 222523003950 putative PBP binding loops; other site 222523003951 ABC-ATPase subunit interface; other site 222523003952 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 222523003953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523003954 motif II; other site 222523003955 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 222523003956 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523003957 catalytic residue [active] 222523003958 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 222523003959 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 222523003960 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 222523003961 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 222523003962 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523003963 heme-binding site [chemical binding]; other site 222523003964 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 222523003965 Leucine-rich repeats; other site 222523003966 Leucine rich repeat; Region: LRR_8; pfam13855 222523003967 Substrate binding site [chemical binding]; other site 222523003968 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523003969 Leucine rich repeat; Region: LRR_8; pfam13855 222523003970 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523003971 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523003972 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523003973 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 222523003974 S-layer homology domain; Region: SLH; pfam00395 222523003975 S-layer homology domain; Region: SLH; pfam00395 222523003976 S-layer homology domain; Region: SLH; pfam00395 222523003977 hypothetical protein; Validated; Region: PRK06755 222523003978 intersubunit interface [polypeptide binding]; other site 222523003979 active site 222523003980 Zn2+ binding site [ion binding]; other site 222523003981 FOG: CBS domain [General function prediction only]; Region: COG0517 222523003982 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 222523003983 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 222523003984 NodB motif; other site 222523003985 putative active site [active] 222523003986 putative catalytic site [active] 222523003987 Zn binding site [ion binding]; other site 222523003988 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 222523003989 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 222523003990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523003991 dimer interface [polypeptide binding]; other site 222523003992 phosphorylation site [posttranslational modification] 222523003993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523003994 ATP binding site [chemical binding]; other site 222523003995 Mg2+ binding site [ion binding]; other site 222523003996 G-X-G motif; other site 222523003997 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523003998 MarR family; Region: MarR; pfam01047 222523003999 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 222523004000 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 222523004001 active site 222523004002 Zn binding site [ion binding]; other site 222523004003 DinB superfamily; Region: DinB_2; pfam12867 222523004004 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 222523004005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523004006 dimer interface [polypeptide binding]; other site 222523004007 phosphorylation site [posttranslational modification] 222523004008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523004009 ATP binding site [chemical binding]; other site 222523004010 Mg2+ binding site [ion binding]; other site 222523004011 G-X-G motif; other site 222523004012 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 222523004013 Ligand Binding Site [chemical binding]; other site 222523004014 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 222523004015 active site 222523004016 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 222523004017 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 222523004018 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 222523004019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523004020 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523004021 Coenzyme A binding pocket [chemical binding]; other site 222523004022 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 222523004023 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 222523004024 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 222523004025 Class I ribonucleotide reductase; Region: RNR_I; cd01679 222523004026 active site 222523004027 dimer interface [polypeptide binding]; other site 222523004028 catalytic residues [active] 222523004029 effector binding site; other site 222523004030 R2 peptide binding site; other site 222523004031 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 222523004032 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 222523004033 dimer interface [polypeptide binding]; other site 222523004034 putative radical transfer pathway; other site 222523004035 diiron center [ion binding]; other site 222523004036 tyrosyl radical; other site 222523004037 Predicted transcriptional regulators [Transcription]; Region: COG1725 222523004038 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523004039 DNA-binding site [nucleotide binding]; DNA binding site 222523004040 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 222523004041 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523004042 Walker A/P-loop; other site 222523004043 ATP binding site [chemical binding]; other site 222523004044 Q-loop/lid; other site 222523004045 ABC transporter signature motif; other site 222523004046 Walker B; other site 222523004047 D-loop; other site 222523004048 H-loop/switch region; other site 222523004049 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523004050 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523004051 Walker A/P-loop; other site 222523004052 ATP binding site [chemical binding]; other site 222523004053 Q-loop/lid; other site 222523004054 ABC transporter signature motif; other site 222523004055 Walker B; other site 222523004056 D-loop; other site 222523004057 H-loop/switch region; other site 222523004058 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 222523004059 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 222523004060 CAAX protease self-immunity; Region: Abi; pfam02517 222523004061 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 222523004062 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 222523004063 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523004064 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523004065 putative DNA binding site [nucleotide binding]; other site 222523004066 putative Zn2+ binding site [ion binding]; other site 222523004067 AsnC family; Region: AsnC_trans_reg; pfam01037 222523004068 Uncharacterized conserved protein [Function unknown]; Region: COG2128 222523004069 SseB protein; Region: SseB; cl06279 222523004070 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 222523004071 dimer interface [polypeptide binding]; other site 222523004072 catalytic triad [active] 222523004073 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 222523004074 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 222523004075 FMN binding site [chemical binding]; other site 222523004076 substrate binding site [chemical binding]; other site 222523004077 putative catalytic residue [active] 222523004078 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 222523004079 DltD N-terminal region; Region: DltD_N; pfam04915 222523004080 DltD central region; Region: DltD_M; pfam04918 222523004081 DltD C-terminal region; Region: DltD_C; pfam04914 222523004082 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 222523004083 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 222523004084 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 222523004085 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 222523004086 acyl-activating enzyme (AAE) consensus motif; other site 222523004087 AMP binding site [chemical binding]; other site 222523004088 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 222523004089 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 222523004090 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 222523004091 metal binding site [ion binding]; metal-binding site 222523004092 dimer interface [polypeptide binding]; other site 222523004093 flavodoxin; Provisional; Region: PRK06756 222523004094 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 222523004095 Phosphotransferase enzyme family; Region: APH; pfam01636 222523004096 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523004097 active site 222523004098 substrate binding site [chemical binding]; other site 222523004099 ATP binding site [chemical binding]; other site 222523004100 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 222523004101 multidrug efflux protein; Reviewed; Region: PRK01766 222523004102 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 222523004103 cation binding site [ion binding]; other site 222523004104 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 222523004105 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 222523004106 hydrophobic ligand binding site; other site 222523004107 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523004108 catalytic residues [active] 222523004109 Regulatory protein YrvL; Region: YrvL; pfam14184 222523004110 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523004111 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 222523004112 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 222523004113 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 222523004114 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 222523004115 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 222523004116 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 222523004117 hypothetical protein; Provisional; Region: PRK03094 222523004118 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 222523004119 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 222523004120 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 222523004121 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 222523004122 homodimer interface [polypeptide binding]; other site 222523004123 substrate-cofactor binding pocket; other site 222523004124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523004125 catalytic residue [active] 222523004126 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 222523004127 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 222523004128 PYR/PP interface [polypeptide binding]; other site 222523004129 dimer interface [polypeptide binding]; other site 222523004130 TPP binding site [chemical binding]; other site 222523004131 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 222523004132 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 222523004133 TPP-binding site [chemical binding]; other site 222523004134 dimer interface [polypeptide binding]; other site 222523004135 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 222523004136 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 222523004137 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 222523004138 ketol-acid reductoisomerase; Provisional; Region: PRK05479 222523004139 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 222523004140 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 222523004141 2-isopropylmalate synthase; Validated; Region: PRK00915 222523004142 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 222523004143 active site 222523004144 catalytic residues [active] 222523004145 metal binding site [ion binding]; metal-binding site 222523004146 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 222523004147 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 222523004148 tartrate dehydrogenase; Region: TTC; TIGR02089 222523004149 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 222523004150 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 222523004151 substrate binding site [chemical binding]; other site 222523004152 ligand binding site [chemical binding]; other site 222523004153 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 222523004154 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 222523004155 substrate binding site [chemical binding]; other site 222523004156 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 222523004157 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 222523004158 dimer interface [polypeptide binding]; other site 222523004159 motif 1; other site 222523004160 active site 222523004161 motif 2; other site 222523004162 motif 3; other site 222523004163 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 222523004164 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 222523004165 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 222523004166 histidinol dehydrogenase; Region: hisD; TIGR00069 222523004167 NAD binding site [chemical binding]; other site 222523004168 dimerization interface [polypeptide binding]; other site 222523004169 product binding site; other site 222523004170 substrate binding site [chemical binding]; other site 222523004171 zinc binding site [ion binding]; other site 222523004172 catalytic residues [active] 222523004173 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 222523004174 putative active site pocket [active] 222523004175 4-fold oligomerization interface [polypeptide binding]; other site 222523004176 metal binding residues [ion binding]; metal-binding site 222523004177 3-fold/trimer interface [polypeptide binding]; other site 222523004178 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 222523004179 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 222523004180 putative active site [active] 222523004181 oxyanion strand; other site 222523004182 catalytic triad [active] 222523004183 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 222523004184 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 222523004185 catalytic residues [active] 222523004186 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 222523004187 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 222523004188 substrate binding site [chemical binding]; other site 222523004189 glutamase interaction surface [polypeptide binding]; other site 222523004190 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 222523004191 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 222523004192 metal binding site [ion binding]; metal-binding site 222523004193 histidinol-phosphatase; Validated; Region: PRK06740 222523004194 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 222523004195 dimer interface [polypeptide binding]; other site 222523004196 active site 222523004197 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 222523004198 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 222523004199 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 222523004200 putative ligand binding site [chemical binding]; other site 222523004201 putative NAD binding site [chemical binding]; other site 222523004202 catalytic site [active] 222523004203 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 222523004204 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 222523004205 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 222523004206 Sulfatase; Region: Sulfatase; pfam00884 222523004207 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 222523004208 diaminopimelate decarboxylase; Region: lysA; TIGR01048 222523004209 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 222523004210 active site 222523004211 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 222523004212 substrate binding site [chemical binding]; other site 222523004213 catalytic residues [active] 222523004214 dimer interface [polypeptide binding]; other site 222523004215 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 222523004216 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 222523004217 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 222523004218 Active Sites [active] 222523004219 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 222523004220 ATP-sulfurylase; Region: ATPS; cd00517 222523004221 active site 222523004222 HXXH motif; other site 222523004223 flexible loop; other site 222523004224 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 222523004225 AAA domain; Region: AAA_18; pfam13238 222523004226 ligand-binding site [chemical binding]; other site 222523004227 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 222523004228 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 222523004229 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 222523004230 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 222523004231 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 222523004232 diphthine synthase; Region: dph5; TIGR00522 222523004233 active site 222523004234 SAM binding site [chemical binding]; other site 222523004235 homodimer interface [polypeptide binding]; other site 222523004236 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 222523004237 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 222523004238 putative active site [active] 222523004239 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 222523004240 putative active site [active] 222523004241 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 222523004242 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 222523004243 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 222523004244 Na2 binding site [ion binding]; other site 222523004245 putative substrate binding site 1 [chemical binding]; other site 222523004246 Na binding site 1 [ion binding]; other site 222523004247 putative substrate binding site 2 [chemical binding]; other site 222523004248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 222523004249 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523004250 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523004251 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 222523004252 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 222523004253 Protein of unknown function (DUF402); Region: DUF402; cl00979 222523004254 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 222523004255 Vpu protein; Region: Vpu; pfam00558 222523004256 PspA/IM30 family; Region: PspA_IM30; pfam04012 222523004257 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 222523004258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523004259 Histidine kinase; Region: HisKA_3; pfam07730 222523004260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523004261 ATP binding site [chemical binding]; other site 222523004262 Mg2+ binding site [ion binding]; other site 222523004263 G-X-G motif; other site 222523004264 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523004265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523004266 active site 222523004267 phosphorylation site [posttranslational modification] 222523004268 intermolecular recognition site; other site 222523004269 dimerization interface [polypeptide binding]; other site 222523004270 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523004271 DNA binding residues [nucleotide binding] 222523004272 dimerization interface [polypeptide binding]; other site 222523004273 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 222523004274 E3 interaction surface; other site 222523004275 lipoyl attachment site [posttranslational modification]; other site 222523004276 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 222523004277 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523004278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523004279 S-adenosylmethionine binding site [chemical binding]; other site 222523004280 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 222523004281 Peptidase family M50; Region: Peptidase_M50; pfam02163 222523004282 active site 222523004283 putative substrate binding region [chemical binding]; other site 222523004284 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 222523004285 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 222523004286 heme-binding site [chemical binding]; other site 222523004287 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 222523004288 FAD binding pocket [chemical binding]; other site 222523004289 FAD binding motif [chemical binding]; other site 222523004290 phosphate binding motif [ion binding]; other site 222523004291 beta-alpha-beta structure motif; other site 222523004292 NAD binding pocket [chemical binding]; other site 222523004293 Heme binding pocket [chemical binding]; other site 222523004294 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 222523004295 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 222523004296 ligand binding site [chemical binding]; other site 222523004297 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 222523004298 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523004299 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 222523004300 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 222523004301 Transglycosylase; Region: Transgly; pfam00912 222523004302 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 222523004303 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523004304 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 222523004305 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 222523004306 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523004307 putative active site [active] 222523004308 heme pocket [chemical binding]; other site 222523004309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523004310 dimer interface [polypeptide binding]; other site 222523004311 phosphorylation site [posttranslational modification] 222523004312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523004313 ATP binding site [chemical binding]; other site 222523004314 Mg2+ binding site [ion binding]; other site 222523004315 G-X-G motif; other site 222523004316 Protein of unknown function DUF72; Region: DUF72; pfam01904 222523004317 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 222523004318 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523004319 active site 222523004320 DNA binding site [nucleotide binding] 222523004321 Int/Topo IB signature motif; other site 222523004322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523004323 dimerization interface [polypeptide binding]; other site 222523004324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523004325 dimer interface [polypeptide binding]; other site 222523004326 phosphorylation site [posttranslational modification] 222523004327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523004328 ATP binding site [chemical binding]; other site 222523004329 Mg2+ binding site [ion binding]; other site 222523004330 G-X-G motif; other site 222523004331 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 222523004332 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 222523004333 Predicted integral membrane protein [Function unknown]; Region: COG0392 222523004334 Uncharacterized conserved protein [Function unknown]; Region: COG2898 222523004335 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 222523004336 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 222523004337 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 222523004338 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 222523004339 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 222523004340 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523004341 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 222523004342 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 222523004343 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 222523004344 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 222523004345 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 222523004346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523004347 RNA binding surface [nucleotide binding]; other site 222523004348 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 222523004349 active site 222523004350 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 222523004351 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 222523004352 catalytic residues [active] 222523004353 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 222523004354 ResB-like family; Region: ResB; pfam05140 222523004355 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 222523004356 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 222523004357 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523004358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523004359 active site 222523004360 phosphorylation site [posttranslational modification] 222523004361 intermolecular recognition site; other site 222523004362 dimerization interface [polypeptide binding]; other site 222523004363 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523004364 DNA binding site [nucleotide binding] 222523004365 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 222523004366 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523004367 dimerization interface [polypeptide binding]; other site 222523004368 PAS domain; Region: PAS; smart00091 222523004369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523004370 dimer interface [polypeptide binding]; other site 222523004371 phosphorylation site [posttranslational modification] 222523004372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523004373 ATP binding site [chemical binding]; other site 222523004374 Mg2+ binding site [ion binding]; other site 222523004375 G-X-G motif; other site 222523004376 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 222523004377 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523004378 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523004379 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523004380 Predicted membrane protein [Function unknown]; Region: COG3601 222523004381 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 222523004382 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 222523004383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 222523004384 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 222523004385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523004386 ATP binding site [chemical binding]; other site 222523004387 putative Mg++ binding site [ion binding]; other site 222523004388 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 222523004389 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523004390 nucleotide binding region [chemical binding]; other site 222523004391 ATP-binding site [chemical binding]; other site 222523004392 CAAX protease self-immunity; Region: Abi; pfam02517 222523004393 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523004394 phosphodiesterase YaeI; Provisional; Region: PRK11340 222523004395 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 222523004396 putative active site [active] 222523004397 putative metal binding site [ion binding]; other site 222523004398 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523004399 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 222523004400 DNA binding residues [nucleotide binding] 222523004401 B12 binding domain; Region: B12-binding_2; pfam02607 222523004402 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 222523004403 adaptor protein; Provisional; Region: PRK02899 222523004404 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 222523004405 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 222523004406 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 222523004407 NAD(P) binding site [chemical binding]; other site 222523004408 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 222523004409 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 222523004410 amidase catalytic site [active] 222523004411 Zn binding residues [ion binding]; other site 222523004412 substrate binding site [chemical binding]; other site 222523004413 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 222523004414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 222523004415 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523004416 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 222523004417 active site 222523004418 homotetramer interface [polypeptide binding]; other site 222523004419 homodimer interface [polypeptide binding]; other site 222523004420 cytidylate kinase; Provisional; Region: cmk; PRK00023 222523004421 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 222523004422 CMP-binding site; other site 222523004423 The sites determining sugar specificity; other site 222523004424 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 222523004425 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 222523004426 RNA binding site [nucleotide binding]; other site 222523004427 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 222523004428 RNA binding site [nucleotide binding]; other site 222523004429 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 222523004430 RNA binding site [nucleotide binding]; other site 222523004431 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 222523004432 RNA binding site [nucleotide binding]; other site 222523004433 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 222523004434 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 222523004435 homotetramer interface [polypeptide binding]; other site 222523004436 FMN binding site [chemical binding]; other site 222523004437 homodimer contacts [polypeptide binding]; other site 222523004438 putative active site [active] 222523004439 putative substrate binding site [chemical binding]; other site 222523004440 YpzI-like protein; Region: YpzI; pfam14140 222523004441 YIEGIA protein; Region: YIEGIA; pfam14045 222523004442 GTP-binding protein Der; Reviewed; Region: PRK00093 222523004443 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 222523004444 G1 box; other site 222523004445 GTP/Mg2+ binding site [chemical binding]; other site 222523004446 Switch I region; other site 222523004447 G2 box; other site 222523004448 Switch II region; other site 222523004449 G3 box; other site 222523004450 G4 box; other site 222523004451 G5 box; other site 222523004452 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 222523004453 G1 box; other site 222523004454 GTP/Mg2+ binding site [chemical binding]; other site 222523004455 Switch I region; other site 222523004456 G2 box; other site 222523004457 G3 box; other site 222523004458 Switch II region; other site 222523004459 G4 box; other site 222523004460 G5 box; other site 222523004461 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 222523004462 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 222523004463 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 222523004464 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 222523004465 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 222523004466 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 222523004467 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 222523004468 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 222523004469 IHF dimer interface [polypeptide binding]; other site 222523004470 IHF - DNA interface [nucleotide binding]; other site 222523004471 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 222523004472 homodecamer interface [polypeptide binding]; other site 222523004473 GTP cyclohydrolase I; Provisional; Region: PLN03044 222523004474 active site 222523004475 putative catalytic site residues [active] 222523004476 zinc binding site [ion binding]; other site 222523004477 GTP-CH-I/GFRP interaction surface; other site 222523004478 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 222523004479 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 222523004480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523004481 S-adenosylmethionine binding site [chemical binding]; other site 222523004482 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 222523004483 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 222523004484 substrate binding pocket [chemical binding]; other site 222523004485 chain length determination region; other site 222523004486 substrate-Mg2+ binding site; other site 222523004487 catalytic residues [active] 222523004488 aspartate-rich region 1; other site 222523004489 active site lid residues [active] 222523004490 aspartate-rich region 2; other site 222523004491 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 222523004492 active site 222523004493 multimer interface [polypeptide binding]; other site 222523004494 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 222523004495 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 222523004496 Tetramer interface [polypeptide binding]; other site 222523004497 active site 222523004498 FMN-binding site [chemical binding]; other site 222523004499 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 222523004500 active site 222523004501 dimer interface [polypeptide binding]; other site 222523004502 metal binding site [ion binding]; metal-binding site 222523004503 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 222523004504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523004505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523004506 homodimer interface [polypeptide binding]; other site 222523004507 catalytic residue [active] 222523004508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523004509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523004510 binding surface 222523004511 TPR motif; other site 222523004512 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 222523004513 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523004514 binding surface 222523004515 TPR motif; other site 222523004516 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523004517 TPR repeat; Region: TPR_11; pfam13414 222523004518 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523004519 binding surface 222523004520 TPR motif; other site 222523004521 hypothetical protein; Provisional; Region: PRK03636 222523004522 UPF0302 domain; Region: UPF0302; pfam08864 222523004523 IDEAL domain; Region: IDEAL; pfam08858 222523004524 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 222523004525 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 222523004526 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 222523004527 iron-sulfur cluster [ion binding]; other site 222523004528 [2Fe-2S] cluster binding site [ion binding]; other site 222523004529 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 222523004530 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 222523004531 interchain domain interface [polypeptide binding]; other site 222523004532 intrachain domain interface; other site 222523004533 heme bH binding site [chemical binding]; other site 222523004534 Qi binding site; other site 222523004535 heme bL binding site [chemical binding]; other site 222523004536 Qo binding site; other site 222523004537 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 222523004538 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 222523004539 interchain domain interface [polypeptide binding]; other site 222523004540 intrachain domain interface; other site 222523004541 Qi binding site; other site 222523004542 Qo binding site; other site 222523004543 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 222523004544 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 222523004545 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 222523004546 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 222523004547 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 222523004548 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 222523004549 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 222523004550 active site 222523004551 Fe-S cluster binding site [ion binding]; other site 222523004552 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523004553 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523004554 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523004555 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523004556 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 222523004557 homodimer interface [polypeptide binding]; other site 222523004558 metal binding site [ion binding]; metal-binding site 222523004559 dihydrodipicolinate reductase; Provisional; Region: PRK00048 222523004560 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 222523004561 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 222523004562 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 222523004563 active site 222523004564 dimer interfaces [polypeptide binding]; other site 222523004565 catalytic residues [active] 222523004566 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 222523004567 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 222523004568 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 222523004569 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 222523004570 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 222523004571 active site 222523004572 NTP binding site [chemical binding]; other site 222523004573 metal binding triad [ion binding]; metal-binding site 222523004574 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 222523004575 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 222523004576 Biotin operon repressor [Transcription]; Region: BirA; COG1654 222523004577 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 222523004578 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 222523004579 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 222523004580 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 222523004581 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 222523004582 oligomerization interface [polypeptide binding]; other site 222523004583 active site 222523004584 metal binding site [ion binding]; metal-binding site 222523004585 pantoate--beta-alanine ligase; Region: panC; TIGR00018 222523004586 Pantoate-beta-alanine ligase; Region: PanC; cd00560 222523004587 active site 222523004588 ATP-binding site [chemical binding]; other site 222523004589 pantoate-binding site; other site 222523004590 HXXH motif; other site 222523004591 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 222523004592 tetramerization interface [polypeptide binding]; other site 222523004593 active site 222523004594 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 222523004595 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 222523004596 active site 222523004597 catalytic site [active] 222523004598 substrate binding site [chemical binding]; other site 222523004599 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 222523004600 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 222523004601 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 222523004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 222523004603 aspartate aminotransferase; Provisional; Region: PRK05764 222523004604 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523004605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523004606 homodimer interface [polypeptide binding]; other site 222523004607 catalytic residue [active] 222523004608 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 222523004609 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 222523004610 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 222523004611 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 222523004612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 222523004613 minor groove reading motif; other site 222523004614 helix-hairpin-helix signature motif; other site 222523004615 substrate binding pocket [chemical binding]; other site 222523004616 active site 222523004617 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 222523004618 Transglycosylase; Region: Transgly; pfam00912 222523004619 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 222523004620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 222523004621 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 222523004622 Interdomain contacts; other site 222523004623 Cytokine receptor motif; other site 222523004624 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 222523004625 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 222523004626 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 222523004627 YppF-like protein; Region: YppF; pfam14178 222523004628 YppG-like protein; Region: YppG; pfam14179 222523004629 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 222523004630 hypothetical protein; Provisional; Region: PRK13660 222523004631 cell division protein GpsB; Provisional; Region: PRK14127 222523004632 DivIVA domain; Region: DivI1A_domain; TIGR03544 222523004633 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 222523004634 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 222523004635 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 222523004636 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 222523004637 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 222523004638 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 222523004639 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 222523004640 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 222523004641 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 222523004642 active site 222523004643 Zn binding site [ion binding]; other site 222523004644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523004645 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523004646 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 222523004647 active site 222523004648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523004649 active site 222523004650 xanthine permease; Region: pbuX; TIGR03173 222523004651 Predicted membrane protein [Function unknown]; Region: COG2311 222523004652 Protein of unknown function (DUF418); Region: DUF418; cl12135 222523004653 Protein of unknown function (DUF418); Region: DUF418; pfam04235 222523004654 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 222523004655 Dynamin family; Region: Dynamin_N; pfam00350 222523004656 G1 box; other site 222523004657 GTP/Mg2+ binding site [chemical binding]; other site 222523004658 G2 box; other site 222523004659 Switch I region; other site 222523004660 G3 box; other site 222523004661 Switch II region; other site 222523004662 G4 box; other site 222523004663 G5 box; other site 222523004664 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 222523004665 Dynamin family; Region: Dynamin_N; pfam00350 222523004666 G1 box; other site 222523004667 GTP/Mg2+ binding site [chemical binding]; other site 222523004668 G2 box; other site 222523004669 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 222523004670 G3 box; other site 222523004671 Switch II region; other site 222523004672 GTP/Mg2+ binding site [chemical binding]; other site 222523004673 G4 box; other site 222523004674 G5 box; other site 222523004675 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 222523004676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523004677 Coenzyme A binding pocket [chemical binding]; other site 222523004678 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 222523004679 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 222523004680 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 222523004681 active site residue [active] 222523004682 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 222523004683 active site residue [active] 222523004684 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 222523004685 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523004686 5'-3' exonuclease; Region: 53EXOc; smart00475 222523004687 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 222523004688 active site 222523004689 metal binding site 1 [ion binding]; metal-binding site 222523004690 putative 5' ssDNA interaction site; other site 222523004691 metal binding site 3; metal-binding site 222523004692 metal binding site 2 [ion binding]; metal-binding site 222523004693 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 222523004694 putative DNA binding site [nucleotide binding]; other site 222523004695 putative metal binding site [ion binding]; other site 222523004696 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 222523004697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523004698 Coenzyme A binding pocket [chemical binding]; other site 222523004699 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 222523004700 Isochorismatase family; Region: Isochorismatase; pfam00857 222523004701 catalytic triad [active] 222523004702 conserved cis-peptide bond; other site 222523004703 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523004704 EamA-like transporter family; Region: EamA; pfam00892 222523004705 EamA-like transporter family; Region: EamA; pfam00892 222523004706 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 222523004707 RNA/DNA hybrid binding site [nucleotide binding]; other site 222523004708 active site 222523004709 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 222523004710 active site 222523004711 catalytic residues [active] 222523004712 QueT transporter; Region: QueT; pfam06177 222523004713 hypothetical protein; Validated; Region: PRK07708 222523004714 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 222523004715 RNA/DNA hybrid binding site [nucleotide binding]; other site 222523004716 active site 222523004717 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 222523004718 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 222523004719 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 222523004720 DNA-binding site [nucleotide binding]; DNA binding site 222523004721 RNA-binding motif; other site 222523004722 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 222523004723 LysE type translocator; Region: LysE; pfam01810 222523004724 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 222523004725 Protein of unknown function, DUF485; Region: DUF485; pfam04341 222523004726 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 222523004727 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 222523004728 Na binding site [ion binding]; other site 222523004729 aminotransferase; Validated; Region: PRK07678 222523004730 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523004731 inhibitor-cofactor binding pocket; inhibition site 222523004732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523004733 catalytic residue [active] 222523004734 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 222523004735 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 222523004736 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 222523004737 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 222523004738 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523004739 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 222523004740 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523004741 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 222523004742 DNA binding residues [nucleotide binding] 222523004743 drug binding residues [chemical binding]; other site 222523004744 dimer interface [polypeptide binding]; other site 222523004745 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 222523004746 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 222523004747 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 222523004748 Predicted membrane protein [Function unknown]; Region: COG2323 222523004749 Uncharacterized conserved protein [Function unknown]; Region: COG1434 222523004750 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 222523004751 putative active site [active] 222523004752 Tic20-like protein; Region: Tic20; pfam09685 222523004753 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 222523004754 dimer interface [polypeptide binding]; other site 222523004755 FMN binding site [chemical binding]; other site 222523004756 NADPH bind site [chemical binding]; other site 222523004757 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523004758 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523004759 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523004760 putative substrate translocation pore; other site 222523004761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523004762 dimerization interface [polypeptide binding]; other site 222523004763 putative DNA binding site [nucleotide binding]; other site 222523004764 putative Zn2+ binding site [ion binding]; other site 222523004765 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523004766 active site 222523004767 metal binding site [ion binding]; metal-binding site 222523004768 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523004769 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 222523004770 bacterial Hfq-like; Region: Hfq; cd01716 222523004771 hexamer interface [polypeptide binding]; other site 222523004772 Sm1 motif; other site 222523004773 RNA binding site [nucleotide binding]; other site 222523004774 Sm2 motif; other site 222523004775 HD domain; Region: HD_3; pfam13023 222523004776 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 222523004777 flagellar motor protein MotP; Reviewed; Region: PRK06743 222523004778 flagellar motor protein MotS; Reviewed; Region: PRK06742 222523004779 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 222523004780 ligand binding site [chemical binding]; other site 222523004781 Response regulator receiver domain; Region: Response_reg; pfam00072 222523004782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523004783 active site 222523004784 phosphorylation site [posttranslational modification] 222523004785 intermolecular recognition site; other site 222523004786 dimerization interface [polypeptide binding]; other site 222523004787 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 222523004788 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 222523004789 putative binding surface; other site 222523004790 active site 222523004791 P2 response regulator binding domain; Region: P2; pfam07194 222523004792 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 222523004793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523004794 ATP binding site [chemical binding]; other site 222523004795 Mg2+ binding site [ion binding]; other site 222523004796 G-X-G motif; other site 222523004797 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 222523004798 flagellar motor switch protein; Reviewed; Region: PRK06782 222523004799 CheC-like family; Region: CheC; pfam04509 222523004800 CheC-like family; Region: CheC; pfam04509 222523004801 CheC-like family; Region: CheC; pfam04509 222523004802 CheC-like family; Region: CheC; pfam04509 222523004803 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 222523004804 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 222523004805 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 222523004806 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 222523004807 Protein of unknown function (DUF327); Region: DUF327; pfam03885 222523004808 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 222523004809 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 222523004810 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 222523004811 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 222523004812 flagellar capping protein; Validated; Region: fliD; PRK06798 222523004813 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 222523004814 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 222523004815 Flagellar protein FliS; Region: FliS; cl00654 222523004816 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 222523004817 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 222523004818 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 222523004819 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 222523004820 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 222523004821 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 222523004822 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 222523004823 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 222523004824 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 222523004825 FliG C-terminal domain; Region: FliG_C; pfam01706 222523004826 flagellar assembly protein H; Validated; Region: fliH; PRK06800 222523004827 Flagellar assembly protein FliH; Region: FliH; pfam02108 222523004828 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 222523004829 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 222523004830 Walker A motif; other site 222523004831 ATP binding site [chemical binding]; other site 222523004832 Walker B motif; other site 222523004833 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 222523004834 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 222523004835 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 222523004836 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 222523004837 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 222523004838 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 222523004839 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 222523004840 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 222523004841 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 222523004842 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 222523004843 Response regulator receiver domain; Region: Response_reg; pfam00072 222523004844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523004845 active site 222523004846 phosphorylation site [posttranslational modification] 222523004847 intermolecular recognition site; other site 222523004848 dimerization interface [polypeptide binding]; other site 222523004849 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 222523004850 flagellin; Provisional; Region: PRK12807 222523004851 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 222523004852 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 222523004853 flagellin; Provisional; Region: PRK12808 222523004854 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 222523004855 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 222523004856 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 222523004857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 222523004858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 222523004859 catalytic residue [active] 222523004860 flagellar motor switch protein; Validated; Region: PRK06789 222523004861 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 222523004862 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 222523004863 flagellar motor switch protein; Validated; Region: PRK06788 222523004864 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 222523004865 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 222523004866 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 222523004867 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 222523004868 FHIPEP family; Region: FHIPEP; pfam00771 222523004869 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 222523004870 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 222523004871 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 222523004872 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 222523004873 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 222523004874 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 222523004875 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 222523004876 Predicted transcriptional regulators [Transcription]; Region: COG1378 222523004877 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 222523004878 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 222523004879 C-terminal domain interface [polypeptide binding]; other site 222523004880 sugar binding site [chemical binding]; other site 222523004881 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 222523004882 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 222523004883 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 222523004884 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523004885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523004886 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 222523004887 Dienelactone hydrolase family; Region: DLH; pfam01738 222523004888 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 222523004889 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 222523004890 active site 222523004891 catalytic site [active] 222523004892 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 222523004893 active site 222523004894 catalytic site [active] 222523004895 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 222523004896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523004897 non-specific DNA binding site [nucleotide binding]; other site 222523004898 salt bridge; other site 222523004899 sequence-specific DNA binding site [nucleotide binding]; other site 222523004900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523004901 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523004902 putative substrate translocation pore; other site 222523004903 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 222523004904 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523004905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523004906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523004907 dimerization interface [polypeptide binding]; other site 222523004908 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 222523004909 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523004910 Walker A/P-loop; other site 222523004911 ATP binding site [chemical binding]; other site 222523004912 Q-loop/lid; other site 222523004913 ABC transporter signature motif; other site 222523004914 Walker B; other site 222523004915 D-loop; other site 222523004916 H-loop/switch region; other site 222523004917 TOBE domain; Region: TOBE_2; pfam08402 222523004918 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 222523004919 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 222523004920 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 222523004921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523004922 dimer interface [polypeptide binding]; other site 222523004923 conserved gate region; other site 222523004924 putative PBP binding loops; other site 222523004925 ABC-ATPase subunit interface; other site 222523004926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523004927 dimer interface [polypeptide binding]; other site 222523004928 conserved gate region; other site 222523004929 putative PBP binding loops; other site 222523004930 ABC-ATPase subunit interface; other site 222523004931 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 222523004932 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 222523004933 Beta-Casp domain; Region: Beta-Casp; smart01027 222523004934 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 222523004935 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 222523004936 short chain dehydrogenase; Provisional; Region: PRK08226 222523004937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523004938 NAD(P) binding site [chemical binding]; other site 222523004939 active site 222523004940 Cupin; Region: Cupin_1; smart00835 222523004941 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 222523004942 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 222523004943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523004944 catalytic core [active] 222523004945 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 222523004946 hypothetical protein; Provisional; Region: PRK09272 222523004947 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 222523004948 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 222523004949 active site 222523004950 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 222523004951 dimer interface [polypeptide binding]; other site 222523004952 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 222523004953 Ligand Binding Site [chemical binding]; other site 222523004954 Molecular Tunnel; other site 222523004955 RNA polymerase factor sigma-70; Validated; Region: PRK06811 222523004956 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523004957 DNA binding residues [nucleotide binding] 222523004958 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 222523004959 VPS10 domain; Region: VPS10; smart00602 222523004960 VPS10 domain; Region: VPS10; smart00602 222523004961 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 222523004962 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 222523004963 Transcriptional regulators [Transcription]; Region: GntR; COG1802 222523004964 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523004965 DNA-binding site [nucleotide binding]; DNA binding site 222523004966 FCD domain; Region: FCD; pfam07729 222523004967 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523004968 EamA-like transporter family; Region: EamA; pfam00892 222523004969 EamA-like transporter family; Region: EamA; pfam00892 222523004970 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 222523004971 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 222523004972 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 222523004973 Predicted permeases [General function prediction only]; Region: COG0701 222523004974 TIGR03943 family protein; Region: TIGR03943 222523004975 Methyltransferase domain; Region: Methyltransf_24; pfam13578 222523004976 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 222523004977 fumarate hydratase; Reviewed; Region: fumC; PRK00485 222523004978 Class II fumarases; Region: Fumarase_classII; cd01362 222523004979 active site 222523004980 tetramer interface [polypeptide binding]; other site 222523004981 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 222523004982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523004983 Walker B; other site 222523004984 D-loop; other site 222523004985 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 222523004986 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 222523004987 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 222523004988 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 222523004989 active site pocket [active] 222523004990 oxyanion hole [active] 222523004991 catalytic triad [active] 222523004992 active site nucleophile [active] 222523004993 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 222523004994 Penicillinase repressor; Region: Pencillinase_R; pfam03965 222523004995 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 222523004996 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 222523004997 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 222523004998 catalytic residues [active] 222523004999 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 222523005000 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 222523005001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523005002 non-specific DNA binding site [nucleotide binding]; other site 222523005003 salt bridge; other site 222523005004 sequence-specific DNA binding site [nucleotide binding]; other site 222523005005 Cupin domain; Region: Cupin_2; pfam07883 222523005006 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 222523005007 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 222523005008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523005009 catalytic residue [active] 222523005010 Protein of unknown function (DUF445); Region: DUF445; pfam04286 222523005011 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 222523005012 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 222523005013 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523005014 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523005015 DNA binding residues [nucleotide binding] 222523005016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523005017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523005018 active site 222523005019 phosphorylation site [posttranslational modification] 222523005020 intermolecular recognition site; other site 222523005021 dimerization interface [polypeptide binding]; other site 222523005022 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523005023 DNA binding residues [nucleotide binding] 222523005024 dimerization interface [polypeptide binding]; other site 222523005025 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523005026 Histidine kinase; Region: HisKA_3; pfam07730 222523005027 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 222523005028 Mg2+ binding site [ion binding]; other site 222523005029 G-X-G motif; other site 222523005030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523005031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523005032 Walker A/P-loop; other site 222523005033 ATP binding site [chemical binding]; other site 222523005034 Q-loop/lid; other site 222523005035 ABC transporter signature motif; other site 222523005036 Walker B; other site 222523005037 D-loop; other site 222523005038 H-loop/switch region; other site 222523005039 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 222523005040 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 222523005041 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 222523005042 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 222523005043 PGAP1-like protein; Region: PGAP1; pfam07819 222523005044 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 222523005045 putative active site [active] 222523005046 catalytic site [active] 222523005047 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 222523005048 PLD-like domain; Region: PLDc_2; pfam13091 222523005049 putative active site [active] 222523005050 catalytic site [active] 222523005051 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 222523005052 putative nucleotide binding site [chemical binding]; other site 222523005053 uridine monophosphate binding site [chemical binding]; other site 222523005054 homohexameric interface [polypeptide binding]; other site 222523005055 aspartate ammonia-lyase; Provisional; Region: PRK14515 222523005056 Aspartase; Region: Aspartase; cd01357 222523005057 active sites [active] 222523005058 tetramer interface [polypeptide binding]; other site 222523005059 malate dehydrogenase; Provisional; Region: PRK13529 222523005060 Malic enzyme, N-terminal domain; Region: malic; pfam00390 222523005061 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 222523005062 NAD(P) binding site [chemical binding]; other site 222523005063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523005064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523005065 ATP binding site [chemical binding]; other site 222523005066 Mg2+ binding site [ion binding]; other site 222523005067 G-X-G motif; other site 222523005068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523005069 Response regulator receiver domain; Region: Response_reg; pfam00072 222523005070 active site 222523005071 phosphorylation site [posttranslational modification] 222523005072 intermolecular recognition site; other site 222523005073 dimerization interface [polypeptide binding]; other site 222523005074 YcbB domain; Region: YcbB; pfam08664 222523005075 SWIM zinc finger; Region: SWIM; pfam04434 222523005076 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 222523005077 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 222523005078 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523005079 ATP binding site [chemical binding]; other site 222523005080 putative Mg++ binding site [ion binding]; other site 222523005081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523005082 nucleotide binding region [chemical binding]; other site 222523005083 ATP-binding site [chemical binding]; other site 222523005084 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 222523005085 dimer interface [polypeptide binding]; other site 222523005086 active site 222523005087 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523005088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523005089 non-specific DNA binding site [nucleotide binding]; other site 222523005090 salt bridge; other site 222523005091 sequence-specific DNA binding site [nucleotide binding]; other site 222523005092 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 222523005093 putative dimer interface [polypeptide binding]; other site 222523005094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523005095 aspartate kinase; Reviewed; Region: PRK06635 222523005096 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 222523005097 putative nucleotide binding site [chemical binding]; other site 222523005098 putative catalytic residues [active] 222523005099 putative Mg ion binding site [ion binding]; other site 222523005100 putative aspartate binding site [chemical binding]; other site 222523005101 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 222523005102 putative allosteric regulatory site; other site 222523005103 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 222523005104 putative allosteric regulatory residue; other site 222523005105 DoxX-like family; Region: DoxX_3; pfam13781 222523005106 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 222523005107 YndJ-like protein; Region: YndJ; pfam14158 222523005108 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 222523005109 putative active site [active] 222523005110 nucleotide binding site [chemical binding]; other site 222523005111 nudix motif; other site 222523005112 putative metal binding site [ion binding]; other site 222523005113 S-layer homology domain; Region: SLH; pfam00395 222523005114 S-layer homology domain; Region: SLH; pfam00395 222523005115 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 222523005116 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 222523005117 active site 222523005118 metal binding site [ion binding]; metal-binding site 222523005119 S-layer homology domain; Region: SLH; pfam00395 222523005120 S-layer homology domain; Region: SLH; pfam00395 222523005121 S-layer homology domain; Region: SLH; pfam00395 222523005122 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 222523005123 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523005124 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523005125 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523005126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523005127 putative substrate translocation pore; other site 222523005128 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 222523005129 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 222523005130 Walker A/P-loop; other site 222523005131 ATP binding site [chemical binding]; other site 222523005132 Q-loop/lid; other site 222523005133 ABC transporter signature motif; other site 222523005134 Walker B; other site 222523005135 D-loop; other site 222523005136 H-loop/switch region; other site 222523005137 TOBE domain; Region: TOBE; pfam03459 222523005138 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 222523005139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 222523005140 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 222523005141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523005142 dimer interface [polypeptide binding]; other site 222523005143 conserved gate region; other site 222523005144 putative PBP binding loops; other site 222523005145 ABC-ATPase subunit interface; other site 222523005146 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 222523005147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523005148 dimer interface [polypeptide binding]; other site 222523005149 conserved gate region; other site 222523005150 putative PBP binding loops; other site 222523005151 ABC-ATPase subunit interface; other site 222523005152 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 222523005153 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 222523005154 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 222523005155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 222523005156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523005157 DNA-binding site [nucleotide binding]; DNA binding site 222523005158 UTRA domain; Region: UTRA; pfam07702 222523005159 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 222523005160 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 222523005161 dimer interface [polypeptide binding]; other site 222523005162 active site 222523005163 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 222523005164 putative active site [active] 222523005165 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 222523005166 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 222523005167 active site 222523005168 dimer interface [polypeptide binding]; other site 222523005169 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 222523005170 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 222523005171 intersubunit interface [polypeptide binding]; other site 222523005172 active site 222523005173 zinc binding site [ion binding]; other site 222523005174 Na+ binding site [ion binding]; other site 222523005175 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 222523005176 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 222523005177 putative substrate binding site [chemical binding]; other site 222523005178 putative ATP binding site [chemical binding]; other site 222523005179 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 222523005180 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 222523005181 nucleotide binding site [chemical binding]; other site 222523005182 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 222523005183 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523005184 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523005185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523005186 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523005187 putative substrate translocation pore; other site 222523005188 CDK-activating kinase assembly factor MAT1; Region: MAT1; pfam06391 222523005189 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 222523005190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523005191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523005192 putative substrate translocation pore; other site 222523005193 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 222523005194 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 222523005195 dimer interface [polypeptide binding]; other site 222523005196 active site 222523005197 CoA binding pocket [chemical binding]; other site 222523005198 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 222523005199 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 222523005200 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 222523005201 HflX GTPase family; Region: HflX; cd01878 222523005202 G1 box; other site 222523005203 GTP/Mg2+ binding site [chemical binding]; other site 222523005204 Switch I region; other site 222523005205 G2 box; other site 222523005206 G3 box; other site 222523005207 Switch II region; other site 222523005208 G4 box; other site 222523005209 G5 box; other site 222523005210 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523005211 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523005212 peptide binding site [polypeptide binding]; other site 222523005213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523005214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523005215 putative substrate translocation pore; other site 222523005216 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 222523005217 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 222523005218 dimer interface [polypeptide binding]; other site 222523005219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523005220 catalytic residue [active] 222523005221 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523005222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005223 Coenzyme A binding pocket [chemical binding]; other site 222523005224 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 222523005225 stage V sporulation protein B; Region: spore_V_B; TIGR02900 222523005226 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 222523005227 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 222523005228 Na2 binding site [ion binding]; other site 222523005229 putative substrate binding site 1 [chemical binding]; other site 222523005230 Na binding site 1 [ion binding]; other site 222523005231 putative substrate binding site 2 [chemical binding]; other site 222523005232 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523005233 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 222523005234 NodB motif; other site 222523005235 putative active site [active] 222523005236 putative catalytic site [active] 222523005237 putative Zn binding site [ion binding]; other site 222523005238 Mor transcription activator family; Region: Mor; cl02360 222523005239 Predicted membrane protein [Function unknown]; Region: COG2323 222523005240 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 222523005241 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 222523005242 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 222523005243 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 222523005244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 222523005245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 222523005246 methionine sulfoxide reductase A; Provisional; Region: PRK14054 222523005247 short chain dehydrogenase; Provisional; Region: PRK12747 222523005248 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 222523005249 NADP binding site [chemical binding]; other site 222523005250 homodimer interface [polypeptide binding]; other site 222523005251 active site 222523005252 substrate binding site [chemical binding]; other site 222523005253 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 222523005254 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 222523005255 homodimer interface [polypeptide binding]; other site 222523005256 substrate-cofactor binding pocket; other site 222523005257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523005258 catalytic residue [active] 222523005259 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 222523005260 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 222523005261 PYR/PP interface [polypeptide binding]; other site 222523005262 dimer interface [polypeptide binding]; other site 222523005263 TPP binding site [chemical binding]; other site 222523005264 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 222523005265 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 222523005266 TPP-binding site [chemical binding]; other site 222523005267 dimer interface [polypeptide binding]; other site 222523005268 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 222523005269 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 222523005270 putative valine binding site [chemical binding]; other site 222523005271 dimer interface [polypeptide binding]; other site 222523005272 ketol-acid reductoisomerase; Provisional; Region: PRK05479 222523005273 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 222523005274 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 222523005275 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 222523005276 threonine dehydratase; Validated; Region: PRK08639 222523005277 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 222523005278 tetramer interface [polypeptide binding]; other site 222523005279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523005280 catalytic residue [active] 222523005281 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 222523005282 putative Ile/Val binding site [chemical binding]; other site 222523005283 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 222523005284 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 222523005285 putative active site [active] 222523005286 putative metal binding site [ion binding]; other site 222523005287 Protein of unknown function (DUF554); Region: DUF554; pfam04474 222523005288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523005289 drug efflux system protein MdtG; Provisional; Region: PRK09874 222523005290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523005291 putative substrate translocation pore; other site 222523005292 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 222523005293 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 222523005294 putative active site [active] 222523005295 metal binding site [ion binding]; metal-binding site 222523005296 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 222523005297 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523005298 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 222523005299 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 222523005300 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 222523005301 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 222523005302 LytTr DNA-binding domain; Region: LytTR; pfam04397 222523005303 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 222523005304 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 222523005305 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 222523005306 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 222523005307 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523005308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005309 Coenzyme A binding pocket [chemical binding]; other site 222523005310 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 222523005311 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 222523005312 active site 222523005313 putative substrate binding pocket [chemical binding]; other site 222523005314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523005315 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 222523005316 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523005317 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523005318 peptide binding site [polypeptide binding]; other site 222523005319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523005320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005321 Coenzyme A binding pocket [chemical binding]; other site 222523005322 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523005323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523005324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523005325 active site 222523005326 phosphorylation site [posttranslational modification] 222523005327 intermolecular recognition site; other site 222523005328 dimerization interface [polypeptide binding]; other site 222523005329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523005330 DNA binding site [nucleotide binding] 222523005331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523005332 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523005333 dimerization interface [polypeptide binding]; other site 222523005334 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523005335 dimer interface [polypeptide binding]; other site 222523005336 phosphorylation site [posttranslational modification] 222523005337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523005338 ATP binding site [chemical binding]; other site 222523005339 Mg2+ binding site [ion binding]; other site 222523005340 G-X-G motif; other site 222523005341 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523005342 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523005343 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523005344 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 222523005345 manganese transport protein MntH; Reviewed; Region: PRK00701 222523005346 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 222523005347 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 222523005348 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 222523005349 active site residue [active] 222523005350 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 222523005351 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 222523005352 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 222523005353 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 222523005354 Amino acid permease; Region: AA_permease_2; pfam13520 222523005355 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 222523005356 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 222523005357 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 222523005358 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 222523005359 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523005360 DNA binding residues [nucleotide binding] 222523005361 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 222523005362 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 222523005363 intersubunit interface [polypeptide binding]; other site 222523005364 active site 222523005365 catalytic residue [active] 222523005366 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523005367 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523005368 Nucleoside recognition; Region: Gate; pfam07670 222523005369 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523005370 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 222523005371 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 222523005372 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 222523005373 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 222523005374 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 222523005375 active site 222523005376 catalytic motif [active] 222523005377 Zn binding site [ion binding]; other site 222523005378 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 222523005379 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 222523005380 hypothetical protein; Provisional; Region: PRK01631 222523005381 proline aminopeptidase P II; Provisional; Region: PRK10879 222523005382 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 222523005383 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 222523005384 active site 222523005385 DNA topoisomerase III; Provisional; Region: PRK07726 222523005386 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 222523005387 active site 222523005388 putative interdomain interaction site [polypeptide binding]; other site 222523005389 putative metal-binding site [ion binding]; other site 222523005390 putative nucleotide binding site [chemical binding]; other site 222523005391 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 222523005392 domain I; other site 222523005393 DNA binding groove [nucleotide binding] 222523005394 phosphate binding site [ion binding]; other site 222523005395 domain II; other site 222523005396 domain III; other site 222523005397 nucleotide binding site [chemical binding]; other site 222523005398 catalytic site [active] 222523005399 domain IV; other site 222523005400 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 222523005401 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 222523005402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523005403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523005404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523005405 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523005406 Walker A/P-loop; other site 222523005407 ATP binding site [chemical binding]; other site 222523005408 Q-loop/lid; other site 222523005409 ABC transporter signature motif; other site 222523005410 Walker B; other site 222523005411 D-loop; other site 222523005412 H-loop/switch region; other site 222523005413 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523005414 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523005415 Walker A/P-loop; other site 222523005416 ATP binding site [chemical binding]; other site 222523005417 Q-loop/lid; other site 222523005418 ABC transporter signature motif; other site 222523005419 Walker B; other site 222523005420 D-loop; other site 222523005421 H-loop/switch region; other site 222523005422 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 222523005423 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 222523005424 Sodium Bile acid symporter family; Region: SBF; cl17470 222523005425 azoreductase; Provisional; Region: PRK13555 222523005426 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 222523005427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523005428 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 222523005429 dimer interface [polypeptide binding]; other site 222523005430 substrate binding site [chemical binding]; other site 222523005431 metal binding site [ion binding]; metal-binding site 222523005432 CopC domain; Region: CopC; pfam04234 222523005433 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 222523005434 YtkA-like; Region: YtkA; pfam13115 222523005435 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 222523005436 EamA-like transporter family; Region: EamA; pfam00892 222523005437 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523005438 EamA-like transporter family; Region: EamA; pfam00892 222523005439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523005440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523005441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523005442 dimerization interface [polypeptide binding]; other site 222523005443 Rrf2 family protein; Region: rrf2_super; TIGR00738 222523005444 Transcriptional regulator; Region: Rrf2; pfam02082 222523005445 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 222523005446 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 222523005447 catalytic residues [active] 222523005448 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 222523005449 dimer interface [polypeptide binding]; other site 222523005450 FMN binding site [chemical binding]; other site 222523005451 amidase; Provisional; Region: PRK06707 222523005452 Amidase; Region: Amidase; cl11426 222523005453 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 222523005454 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 222523005455 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 222523005456 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523005457 NAD binding site [chemical binding]; other site 222523005458 dimer interface [polypeptide binding]; other site 222523005459 substrate binding site [chemical binding]; other site 222523005460 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 222523005461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 222523005462 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 222523005463 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 222523005464 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 222523005465 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 222523005466 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 222523005467 putative ligand binding site [chemical binding]; other site 222523005468 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 222523005469 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 222523005470 Walker A/P-loop; other site 222523005471 ATP binding site [chemical binding]; other site 222523005472 Q-loop/lid; other site 222523005473 ABC transporter signature motif; other site 222523005474 Walker B; other site 222523005475 D-loop; other site 222523005476 H-loop/switch region; other site 222523005477 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 222523005478 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 222523005479 Walker A/P-loop; other site 222523005480 ATP binding site [chemical binding]; other site 222523005481 Q-loop/lid; other site 222523005482 ABC transporter signature motif; other site 222523005483 Walker B; other site 222523005484 D-loop; other site 222523005485 H-loop/switch region; other site 222523005486 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 222523005487 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 222523005488 TM-ABC transporter signature motif; other site 222523005489 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 222523005490 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 222523005491 TM-ABC transporter signature motif; other site 222523005492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523005493 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 222523005494 LysR substrate binding domain; Region: LysR_substrate; pfam03466 222523005495 dimerization interface [polypeptide binding]; other site 222523005496 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 222523005497 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523005498 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523005499 putative Zn2+ binding site [ion binding]; other site 222523005500 putative DNA binding site [nucleotide binding]; other site 222523005501 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 222523005502 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 222523005503 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 222523005504 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 222523005505 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 222523005506 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 222523005507 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 222523005508 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 222523005509 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523005510 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 222523005511 Walker A/P-loop; other site 222523005512 ATP binding site [chemical binding]; other site 222523005513 Q-loop/lid; other site 222523005514 ABC transporter signature motif; other site 222523005515 Walker B; other site 222523005516 D-loop; other site 222523005517 H-loop/switch region; other site 222523005518 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 222523005519 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523005520 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 222523005521 Walker A/P-loop; other site 222523005522 ATP binding site [chemical binding]; other site 222523005523 Q-loop/lid; other site 222523005524 ABC transporter signature motif; other site 222523005525 Walker B; other site 222523005526 D-loop; other site 222523005527 H-loop/switch region; other site 222523005528 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 222523005529 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 222523005530 active site 222523005531 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 222523005532 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523005533 active site 222523005534 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523005535 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523005536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 222523005537 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 222523005538 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 222523005539 inhibitor-cofactor binding pocket; inhibition site 222523005540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523005541 catalytic residue [active] 222523005542 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 222523005543 trimer interface [polypeptide binding]; other site 222523005544 active site 222523005545 substrate binding site [chemical binding]; other site 222523005546 CoA binding site [chemical binding]; other site 222523005547 EamA-like transporter family; Region: EamA; pfam00892 222523005548 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 222523005549 putative dimer interface [polypeptide binding]; other site 222523005550 catalytic triad [active] 222523005551 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523005552 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 222523005553 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 222523005554 dimer interface [polypeptide binding]; other site 222523005555 FMN binding site [chemical binding]; other site 222523005556 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523005557 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523005558 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523005559 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 222523005560 NlpC/P60 family; Region: NLPC_P60; pfam00877 222523005561 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523005562 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523005563 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523005564 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523005565 Walker A/P-loop; other site 222523005566 ATP binding site [chemical binding]; other site 222523005567 Q-loop/lid; other site 222523005568 ABC transporter signature motif; other site 222523005569 Walker B; other site 222523005570 D-loop; other site 222523005571 H-loop/switch region; other site 222523005572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523005573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523005574 active site 222523005575 phosphorylation site [posttranslational modification] 222523005576 intermolecular recognition site; other site 222523005577 dimerization interface [polypeptide binding]; other site 222523005578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523005579 DNA binding site [nucleotide binding] 222523005580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523005581 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523005582 dimerization interface [polypeptide binding]; other site 222523005583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523005584 dimer interface [polypeptide binding]; other site 222523005585 phosphorylation site [posttranslational modification] 222523005586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523005587 ATP binding site [chemical binding]; other site 222523005588 Mg2+ binding site [ion binding]; other site 222523005589 G-X-G motif; other site 222523005590 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 222523005591 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 222523005592 classical (c) SDRs; Region: SDR_c; cd05233 222523005593 NAD(P) binding site [chemical binding]; other site 222523005594 active site 222523005595 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 222523005596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523005597 S-adenosylmethionine binding site [chemical binding]; other site 222523005598 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 222523005599 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523005600 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 222523005601 NodB motif; other site 222523005602 active site 222523005603 catalytic site [active] 222523005604 metal binding site [ion binding]; metal-binding site 222523005605 SdpI/YhfL protein family; Region: SdpI; pfam13630 222523005606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 222523005607 nudix motif; other site 222523005608 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 222523005609 homoserine dehydrogenase; Provisional; Region: PRK06349 222523005610 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 222523005611 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 222523005612 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 222523005613 threonine synthase; Reviewed; Region: PRK06721 222523005614 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 222523005615 homodimer interface [polypeptide binding]; other site 222523005616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523005617 catalytic residue [active] 222523005618 homoserine kinase; Provisional; Region: PRK01212 222523005619 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 222523005620 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 222523005621 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 222523005622 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 222523005623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523005624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523005625 active site 222523005626 phosphorylation site [posttranslational modification] 222523005627 intermolecular recognition site; other site 222523005628 dimerization interface [polypeptide binding]; other site 222523005629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523005630 DNA binding site [nucleotide binding] 222523005631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523005632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523005633 dimerization interface [polypeptide binding]; other site 222523005634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523005635 dimer interface [polypeptide binding]; other site 222523005636 phosphorylation site [posttranslational modification] 222523005637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523005638 ATP binding site [chemical binding]; other site 222523005639 Mg2+ binding site [ion binding]; other site 222523005640 G-X-G motif; other site 222523005641 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523005642 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 222523005643 NodB motif; other site 222523005644 active site 222523005645 catalytic site [active] 222523005646 Zn binding site [ion binding]; other site 222523005647 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 222523005648 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 222523005649 MgtC family; Region: MgtC; pfam02308 222523005650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523005651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005652 Coenzyme A binding pocket [chemical binding]; other site 222523005653 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 222523005654 Lysine efflux permease [General function prediction only]; Region: COG1279 222523005655 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 222523005656 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 222523005657 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 222523005658 active site 222523005659 nucleophile elbow; other site 222523005660 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 222523005661 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 222523005662 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 222523005663 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 222523005664 nudix motif; other site 222523005665 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 222523005666 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 222523005667 homodimer interface [polypeptide binding]; other site 222523005668 NAD binding pocket [chemical binding]; other site 222523005669 ATP binding pocket [chemical binding]; other site 222523005670 Mg binding site [ion binding]; other site 222523005671 active-site loop [active] 222523005672 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523005673 FtsX-like permease family; Region: FtsX; pfam02687 222523005674 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 222523005675 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 222523005676 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 222523005677 active site 222523005678 catalytic residues [active] 222523005679 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523005680 dimerization interface [polypeptide binding]; other site 222523005681 putative DNA binding site [nucleotide binding]; other site 222523005682 putative Zn2+ binding site [ion binding]; other site 222523005683 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 222523005684 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 222523005685 active site 222523005686 catalytic tetrad [active] 222523005687 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 222523005688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523005689 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 222523005690 Protein of unknown function (DUF664); Region: DUF664; pfam04978 222523005691 GTPase RsgA; Reviewed; Region: PRK01889 222523005692 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 222523005693 RNA binding site [nucleotide binding]; other site 222523005694 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 222523005695 GTPase/Zn-binding domain interface [polypeptide binding]; other site 222523005696 GTP/Mg2+ binding site [chemical binding]; other site 222523005697 G4 box; other site 222523005698 G5 box; other site 222523005699 G1 box; other site 222523005700 Switch I region; other site 222523005701 G2 box; other site 222523005702 G3 box; other site 222523005703 Switch II region; other site 222523005704 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 222523005705 Cache domain; Region: Cache_1; pfam02743 222523005706 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 222523005707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523005708 dimerization interface [polypeptide binding]; other site 222523005709 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523005710 dimer interface [polypeptide binding]; other site 222523005711 putative CheW interface [polypeptide binding]; other site 222523005712 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 222523005713 Uncharacterized membrane protein [Function unknown]; Region: COG3949 222523005714 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 222523005715 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 222523005716 dimerization interface [polypeptide binding]; other site 222523005717 DPS ferroxidase diiron center [ion binding]; other site 222523005718 ion pore; other site 222523005719 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 222523005720 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 222523005721 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 222523005722 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 222523005723 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 222523005724 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 222523005725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 222523005726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523005727 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523005728 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 222523005729 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 222523005730 active site 222523005731 catalytic tetrad [active] 222523005732 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 222523005733 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 222523005734 P-loop, Walker A motif; other site 222523005735 Base recognition motif; other site 222523005736 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 222523005737 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523005738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005739 Coenzyme A binding pocket [chemical binding]; other site 222523005740 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 222523005741 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 222523005742 metal binding site [ion binding]; metal-binding site 222523005743 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 222523005744 NADH(P)-binding; Region: NAD_binding_10; pfam13460 222523005745 NAD binding site [chemical binding]; other site 222523005746 active site 222523005747 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 222523005748 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 222523005749 active site 222523005750 FMN binding site [chemical binding]; other site 222523005751 substrate binding site [chemical binding]; other site 222523005752 homotetramer interface [polypeptide binding]; other site 222523005753 catalytic residue [active] 222523005754 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 222523005755 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 222523005756 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 222523005757 DNA binding site [nucleotide binding] 222523005758 active site 222523005759 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 222523005760 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523005761 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523005762 peptide binding site [polypeptide binding]; other site 222523005763 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 222523005764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523005765 active site 222523005766 metal binding site [ion binding]; metal-binding site 222523005767 short chain dehydrogenase; Provisional; Region: PRK08309 222523005768 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523005769 catalytic core [active] 222523005770 ssDNA binding protein; Region: Viral_DNA_bp; cl17757 222523005771 CotH protein; Region: CotH; pfam08757 222523005772 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 222523005773 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 222523005774 nudix motif; other site 222523005775 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 222523005776 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523005777 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 222523005778 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 222523005779 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 222523005780 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 222523005781 Cl binding site [ion binding]; other site 222523005782 oligomer interface [polypeptide binding]; other site 222523005783 Predicted permeases [General function prediction only]; Region: COG0701 222523005784 Predicted membrane protein [Function unknown]; Region: COG3689 222523005785 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 222523005786 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 222523005787 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 222523005788 putative active site [active] 222523005789 catalytic site [active] 222523005790 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 222523005791 putative active site [active] 222523005792 catalytic site [active] 222523005793 Coat F domain; Region: Coat_F; pfam07875 222523005794 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 222523005795 NADH(P)-binding; Region: NAD_binding_10; pfam13460 222523005796 NAD binding site [chemical binding]; other site 222523005797 substrate binding site [chemical binding]; other site 222523005798 putative active site [active] 222523005799 Protein of unknown function (DUF456); Region: DUF456; pfam04306 222523005800 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 222523005801 Domain of unknown function DUF21; Region: DUF21; pfam01595 222523005802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 222523005803 Transporter associated domain; Region: CorC_HlyC; smart01091 222523005804 FOG: CBS domain [General function prediction only]; Region: COG0517 222523005805 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 222523005806 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 222523005807 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 222523005808 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 222523005809 dimer interface [polypeptide binding]; other site 222523005810 putative tRNA-binding site [nucleotide binding]; other site 222523005811 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 222523005812 DinB superfamily; Region: DinB_2; pfam12867 222523005813 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 222523005814 stage II sporulation protein P; Region: spore_II_P; TIGR02867 222523005815 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523005816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005817 Coenzyme A binding pocket [chemical binding]; other site 222523005818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523005819 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 222523005820 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 222523005821 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 222523005822 nudix motif; other site 222523005823 amidase; Provisional; Region: PRK06828 222523005824 Amidase; Region: Amidase; pfam01425 222523005825 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523005826 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 222523005827 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 222523005828 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 222523005829 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 222523005830 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 222523005831 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 222523005832 Transcriptional regulator [Transcription]; Region: IclR; COG1414 222523005833 Bacterial transcriptional regulator; Region: IclR; pfam01614 222523005834 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 222523005835 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 222523005836 active site 222523005837 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 222523005838 Amidohydrolase; Region: Amidohydro_2; pfam04909 222523005839 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 222523005840 homotrimer interaction site [polypeptide binding]; other site 222523005841 putative active site [active] 222523005842 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 222523005843 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 222523005844 NAD binding site [chemical binding]; other site 222523005845 catalytic residues [active] 222523005846 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 222523005847 acetaldehyde dehydrogenase; Validated; Region: PRK08300 222523005848 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 222523005849 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 222523005850 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 222523005851 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 222523005852 active site 222523005853 catalytic residues [active] 222523005854 metal binding site [ion binding]; metal-binding site 222523005855 DmpG-like communication domain; Region: DmpG_comm; pfam07836 222523005856 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 222523005857 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 222523005858 active site 1 [active] 222523005859 dimer interface [polypeptide binding]; other site 222523005860 hexamer interface [polypeptide binding]; other site 222523005861 active site 2 [active] 222523005862 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523005863 catalytic core [active] 222523005864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523005865 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523005866 active site 222523005867 motif I; other site 222523005868 motif II; other site 222523005869 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523005870 DinB superfamily; Region: DinB_2; pfam12867 222523005871 DinB family; Region: DinB; cl17821 222523005872 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 222523005873 alanine racemase; Reviewed; Region: alr; PRK00053 222523005874 active site 222523005875 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 222523005876 dimer interface [polypeptide binding]; other site 222523005877 substrate binding site [chemical binding]; other site 222523005878 catalytic residues [active] 222523005879 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523005880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523005881 S-adenosylmethionine binding site [chemical binding]; other site 222523005882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005883 Coenzyme A binding pocket [chemical binding]; other site 222523005884 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523005885 active site 222523005886 Phosphotransferase enzyme family; Region: APH; pfam01636 222523005887 ATP binding site [chemical binding]; other site 222523005888 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 222523005889 glycosyltransferase, MGT family; Region: MGT; TIGR01426 222523005890 active site 222523005891 TDP-binding site; other site 222523005892 acceptor substrate-binding pocket; other site 222523005893 homodimer interface [polypeptide binding]; other site 222523005894 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523005895 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523005896 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523005897 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523005898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523005899 DNA-binding site [nucleotide binding]; DNA binding site 222523005900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523005901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523005902 homodimer interface [polypeptide binding]; other site 222523005903 catalytic residue [active] 222523005904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005905 Coenzyme A binding pocket [chemical binding]; other site 222523005906 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523005907 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 222523005908 active site 222523005909 metal binding site [ion binding]; metal-binding site 222523005910 Src Homology 3 domain superfamily; Region: SH3; cl17036 222523005911 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523005912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005913 Coenzyme A binding pocket [chemical binding]; other site 222523005914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523005915 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 222523005916 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523005917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005918 Coenzyme A binding pocket [chemical binding]; other site 222523005919 Cupin domain; Region: Cupin_2; cl17218 222523005920 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523005921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005922 Coenzyme A binding pocket [chemical binding]; other site 222523005923 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523005924 active site 222523005925 ATP binding site [chemical binding]; other site 222523005926 Phosphotransferase enzyme family; Region: APH; pfam01636 222523005927 substrate binding site [chemical binding]; other site 222523005928 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523005929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523005930 Coenzyme A binding pocket [chemical binding]; other site 222523005931 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 222523005932 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523005933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523005934 S-adenosylmethionine binding site [chemical binding]; other site 222523005935 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 222523005936 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 222523005937 Potassium binding sites [ion binding]; other site 222523005938 Cesium cation binding sites [ion binding]; other site 222523005939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 222523005940 DEAD-like helicases superfamily; Region: DEXDc; smart00487 222523005941 ATP binding site [chemical binding]; other site 222523005942 putative Mg++ binding site [ion binding]; other site 222523005943 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523005944 nucleotide binding region [chemical binding]; other site 222523005945 ATP-binding site [chemical binding]; other site 222523005946 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523005947 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 222523005948 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523005949 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 222523005950 NADP binding site [chemical binding]; other site 222523005951 dimer interface [polypeptide binding]; other site 222523005952 RNA polymerase sigma factor; Provisional; Region: PRK12543 222523005953 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523005954 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523005955 DNA binding residues [nucleotide binding] 222523005956 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 222523005957 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 222523005958 ABC1 family; Region: ABC1; cl17513 222523005959 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 222523005960 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 222523005961 catalytic residues [active] 222523005962 dimer interface [polypeptide binding]; other site 222523005963 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 222523005964 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 222523005965 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 222523005966 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 222523005967 Protein of unknown function DUF58; Region: DUF58; pfam01882 222523005968 MoxR-like ATPases [General function prediction only]; Region: COG0714 222523005969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523005970 Walker A motif; other site 222523005971 ATP binding site [chemical binding]; other site 222523005972 Walker B motif; other site 222523005973 arginine finger; other site 222523005974 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 222523005975 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 222523005976 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 222523005977 molybdopterin cofactor binding site; other site 222523005978 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 222523005979 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 222523005980 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 222523005981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 222523005982 nucleotide binding site [chemical binding]; other site 222523005983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 222523005984 xylose isomerase; Provisional; Region: PRK05474 222523005985 xylose isomerase; Region: xylose_isom_A; TIGR02630 222523005986 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 222523005987 N- and C-terminal domain interface [polypeptide binding]; other site 222523005988 D-xylulose kinase; Region: XylB; TIGR01312 222523005989 active site 222523005990 MgATP binding site [chemical binding]; other site 222523005991 catalytic site [active] 222523005992 metal binding site [ion binding]; metal-binding site 222523005993 xylulose binding site [chemical binding]; other site 222523005994 homodimer interface [polypeptide binding]; other site 222523005995 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 222523005996 active site 222523005997 catalytic residues [active] 222523005998 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 222523005999 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006000 putative substrate translocation pore; other site 222523006001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006002 Excalibur calcium-binding domain; Region: Excalibur; smart00894 222523006003 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 222523006004 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 222523006005 PGAP1-like protein; Region: PGAP1; pfam07819 222523006006 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 222523006007 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 222523006008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523006009 Zn2+ binding site [ion binding]; other site 222523006010 Mg2+ binding site [ion binding]; other site 222523006011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 222523006012 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 222523006013 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523006014 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523006015 ABC transporter; Region: ABC_tran_2; pfam12848 222523006016 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523006017 Bax inhibitor 1 like; Region: BaxI_1; cl17691 222523006018 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 222523006019 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 222523006020 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 222523006021 dimer interface [polypeptide binding]; other site 222523006022 ssDNA binding site [nucleotide binding]; other site 222523006023 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523006024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523006025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523006026 hypothetical protein; Provisional; Region: PRK06753 222523006027 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 222523006028 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; cl07364 222523006029 Virulence factor; Region: Virulence_fact; pfam13769 222523006030 HEAT repeats; Region: HEAT_2; pfam13646 222523006031 HEAT repeats; Region: HEAT_2; pfam13646 222523006032 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 222523006033 Protein of unknown function, DUF393; Region: DUF393; pfam04134 222523006034 Disulphide isomerase; Region: Disulph_isomer; pfam06491 222523006035 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 222523006036 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 222523006037 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 222523006038 HIGH motif; other site 222523006039 active site 222523006040 KMSK motif region; other site 222523006041 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 222523006042 tRNA binding surface [nucleotide binding]; other site 222523006043 anticodon binding site; other site 222523006044 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 222523006045 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523006046 Methyltransferase domain; Region: Methyltransf_12; pfam08242 222523006047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006048 binding surface 222523006049 TPR motif; other site 222523006050 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 222523006051 putative active site [active] 222523006052 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006053 binding surface 222523006054 TPR motif; other site 222523006055 TPR repeat; Region: TPR_11; pfam13414 222523006056 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006057 binding surface 222523006058 TPR motif; other site 222523006059 Tetratricopeptide repeat; Region: TPR_16; pfam13432 222523006060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006061 binding surface 222523006062 TPR motif; other site 222523006063 TPR repeat; Region: TPR_11; pfam13414 222523006064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006065 binding surface 222523006066 TPR motif; other site 222523006067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006068 TPR motif; other site 222523006069 binding surface 222523006070 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006071 binding surface 222523006072 TPR motif; other site 222523006073 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523006074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523006075 binding surface 222523006076 TPR motif; other site 222523006077 TPR repeat; Region: TPR_11; pfam13414 222523006078 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 222523006079 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 222523006080 HIGH motif; other site 222523006081 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 222523006082 active site 222523006083 KMSKS motif; other site 222523006084 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 222523006085 tRNA binding surface [nucleotide binding]; other site 222523006086 anticodon binding site; other site 222523006087 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 222523006088 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 222523006089 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 222523006090 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 222523006091 Zn binding site [ion binding]; other site 222523006092 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 222523006093 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 222523006094 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523006095 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523006096 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 222523006097 Na2 binding site [ion binding]; other site 222523006098 putative substrate binding site 1 [chemical binding]; other site 222523006099 Na binding site 1 [ion binding]; other site 222523006100 putative substrate binding site 2 [chemical binding]; other site 222523006101 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523006102 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 222523006103 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 222523006104 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 222523006105 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523006106 motif II; other site 222523006107 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 222523006108 fructuronate transporter; Provisional; Region: PRK10034; cl15264 222523006109 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 222523006110 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 222523006111 active site 222523006112 NAD binding site [chemical binding]; other site 222523006113 metal binding site [ion binding]; metal-binding site 222523006114 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 222523006115 aspartate racemase; Region: asp_race; TIGR00035 222523006116 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 222523006117 homodimer interaction site [polypeptide binding]; other site 222523006118 cofactor binding site; other site 222523006119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523006120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006121 Coenzyme A binding pocket [chemical binding]; other site 222523006122 hypothetical protein; Validated; Region: PRK06769 222523006123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523006124 active site 222523006125 motif I; other site 222523006126 motif II; other site 222523006127 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523006128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006129 Coenzyme A binding pocket [chemical binding]; other site 222523006130 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 222523006131 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523006132 Walker A/P-loop; other site 222523006133 ATP binding site [chemical binding]; other site 222523006134 Q-loop/lid; other site 222523006135 ABC transporter signature motif; other site 222523006136 Walker B; other site 222523006137 D-loop; other site 222523006138 H-loop/switch region; other site 222523006139 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 222523006140 YpjP-like protein; Region: YpjP; pfam14005 222523006141 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 222523006142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523006143 motif II; other site 222523006144 Phosphotransferase enzyme family; Region: APH; pfam01636 222523006145 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523006146 active site 222523006147 substrate binding site [chemical binding]; other site 222523006148 ATP binding site [chemical binding]; other site 222523006149 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523006150 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523006151 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 222523006152 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 222523006153 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 222523006154 thymidylate synthase; Region: thym_sym; TIGR03284 222523006155 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 222523006156 dimerization interface [polypeptide binding]; other site 222523006157 active site 222523006158 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 222523006159 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 222523006160 folate binding site [chemical binding]; other site 222523006161 NADP+ binding site [chemical binding]; other site 222523006162 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 222523006163 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523006164 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 222523006165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523006166 azoreductase; Reviewed; Region: PRK00170 222523006167 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 222523006168 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 222523006169 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 222523006170 putative acyl-acceptor binding pocket; other site 222523006171 Haemolysin-III related; Region: HlyIII; cl03831 222523006172 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 222523006173 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 222523006174 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 222523006175 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 222523006176 EDD domain protein, DegV family; Region: DegV; TIGR00762 222523006177 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 222523006178 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 222523006179 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 222523006180 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 222523006181 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 222523006182 Cu(I) binding site [ion binding]; other site 222523006183 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 222523006184 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 222523006185 putative dimer interface [polypeptide binding]; other site 222523006186 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 222523006187 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 222523006188 dimer interface [polypeptide binding]; other site 222523006189 active site 222523006190 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 222523006191 Ligand Binding Site [chemical binding]; other site 222523006192 Molecular Tunnel; other site 222523006193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523006194 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 222523006195 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 222523006196 siderophore binding site; other site 222523006197 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 222523006198 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 222523006199 homodimer interface [polypeptide binding]; other site 222523006200 substrate-cofactor binding pocket; other site 222523006201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523006202 catalytic residue [active] 222523006203 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 222523006204 FMN binding site [chemical binding]; other site 222523006205 dimer interface [polypeptide binding]; other site 222523006206 Isochorismatase family; Region: Isochorismatase; pfam00857 222523006207 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 222523006208 catalytic triad [active] 222523006209 conserved cis-peptide bond; other site 222523006210 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 222523006211 nudix motif; other site 222523006212 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 222523006213 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 222523006214 putative dimer interface [polypeptide binding]; other site 222523006215 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 222523006216 Mechanosensitive ion channel; Region: MS_channel; pfam00924 222523006217 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 222523006218 GAF domain; Region: GAF; pfam01590 222523006219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523006220 Histidine kinase; Region: HisKA_3; pfam07730 222523006221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523006222 ATP binding site [chemical binding]; other site 222523006223 Mg2+ binding site [ion binding]; other site 222523006224 G-X-G motif; other site 222523006225 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523006226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523006227 active site 222523006228 phosphorylation site [posttranslational modification] 222523006229 intermolecular recognition site; other site 222523006230 dimerization interface [polypeptide binding]; other site 222523006231 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523006232 DNA binding residues [nucleotide binding] 222523006233 dimerization interface [polypeptide binding]; other site 222523006234 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523006235 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523006236 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 222523006237 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 222523006238 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 222523006239 putative active site [active] 222523006240 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 222523006241 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 222523006242 NAD binding site [chemical binding]; other site 222523006243 substrate binding site [chemical binding]; other site 222523006244 catalytic Zn binding site [ion binding]; other site 222523006245 tetramer interface [polypeptide binding]; other site 222523006246 structural Zn binding site [ion binding]; other site 222523006247 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523006248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523006249 dimer interface [polypeptide binding]; other site 222523006250 conserved gate region; other site 222523006251 ABC-ATPase subunit interface; other site 222523006252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523006253 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523006254 dimer interface [polypeptide binding]; other site 222523006255 conserved gate region; other site 222523006256 putative PBP binding loops; other site 222523006257 ABC-ATPase subunit interface; other site 222523006258 DJ-1 family protein; Region: not_thiJ; TIGR01383 222523006259 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 222523006260 conserved cys residue [active] 222523006261 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523006262 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 222523006263 putative DNA binding site [nucleotide binding]; other site 222523006264 putative Zn2+ binding site [ion binding]; other site 222523006265 AsnC family; Region: AsnC_trans_reg; pfam01037 222523006266 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 222523006267 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 222523006268 N- and C-terminal domain interface [polypeptide binding]; other site 222523006269 active site 222523006270 catalytic site [active] 222523006271 metal binding site [ion binding]; metal-binding site 222523006272 carbohydrate binding site [chemical binding]; other site 222523006273 ATP binding site [chemical binding]; other site 222523006274 fructuronate transporter; Provisional; Region: PRK10034; cl15264 222523006275 GntP family permease; Region: GntP_permease; pfam02447 222523006276 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 222523006277 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 222523006278 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 222523006279 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 222523006280 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523006281 active site 222523006282 Predicted flavoprotein [General function prediction only]; Region: COG0431 222523006283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 222523006284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006285 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523006286 putative substrate translocation pore; other site 222523006287 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 222523006288 Uncharacterized conserved protein [Function unknown]; Region: COG1434 222523006289 putative active site [active] 222523006290 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 222523006291 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 222523006292 Walker A/P-loop; other site 222523006293 ATP binding site [chemical binding]; other site 222523006294 Q-loop/lid; other site 222523006295 ABC transporter signature motif; other site 222523006296 Walker B; other site 222523006297 D-loop; other site 222523006298 H-loop/switch region; other site 222523006299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523006300 dimer interface [polypeptide binding]; other site 222523006301 conserved gate region; other site 222523006302 ABC-ATPase subunit interface; other site 222523006303 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 222523006304 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 222523006305 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 222523006306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 222523006307 Protein of unknown function (DUF524); Region: DUF524; pfam04411 222523006308 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 222523006309 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 222523006310 DNA binding residues [nucleotide binding] 222523006311 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 222523006312 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 222523006313 NAD(P) binding site [chemical binding]; other site 222523006314 catalytic residues [active] 222523006315 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 222523006316 Histidine kinase N terminal; Region: HisK_N; pfam09385 222523006317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523006318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523006319 dimer interface [polypeptide binding]; other site 222523006320 phosphorylation site [posttranslational modification] 222523006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523006322 ATP binding site [chemical binding]; other site 222523006323 Mg2+ binding site [ion binding]; other site 222523006324 G-X-G motif; other site 222523006325 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 222523006326 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 222523006327 hypothetical protein; Provisional; Region: PRK06917 222523006328 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523006329 inhibitor-cofactor binding pocket; inhibition site 222523006330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523006331 catalytic residue [active] 222523006332 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 222523006333 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 222523006334 acetylornithine deacetylase; Validated; Region: PRK06915 222523006335 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 222523006336 metal binding site [ion binding]; metal-binding site 222523006337 dimer interface [polypeptide binding]; other site 222523006338 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 222523006339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523006340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 222523006341 PAS fold; Region: PAS_4; pfam08448 222523006342 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 222523006343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523006344 Walker A motif; other site 222523006345 ATP binding site [chemical binding]; other site 222523006346 Walker B motif; other site 222523006347 arginine finger; other site 222523006348 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 222523006349 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 222523006350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523006351 FeS/SAM binding site; other site 222523006352 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 222523006353 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 222523006354 toxin interface [polypeptide binding]; other site 222523006355 Zn binding site [ion binding]; other site 222523006356 hypothetical protein; Provisional; Region: PRK13672 222523006357 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 222523006358 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 222523006359 Catalytic domain of Protein Kinases; Region: PKc; cd00180 222523006360 active site 222523006361 ATP binding site [chemical binding]; other site 222523006362 substrate binding site [chemical binding]; other site 222523006363 activation loop (A-loop); other site 222523006364 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 222523006365 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 222523006366 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 222523006367 active site 222523006368 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 222523006369 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 222523006370 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523006371 catalytic residues [active] 222523006372 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 222523006373 Terminase small subunit; Region: Terminase_2; cl01513 222523006374 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 222523006375 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 222523006376 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523006377 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523006378 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523006379 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523006380 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 222523006381 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 222523006382 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 222523006383 YolD-like protein; Region: YolD; pfam08863 222523006384 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523006385 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 222523006386 KTSC domain; Region: KTSC; pfam13619 222523006387 Transglycosylase; Region: Transgly; pfam00912 222523006388 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 222523006389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523006390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523006392 putative substrate translocation pore; other site 222523006393 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 222523006394 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 222523006395 dimer interface [polypeptide binding]; other site 222523006396 Citrate synthase; Region: Citrate_synt; pfam00285 222523006397 active site 222523006398 coenzyme A binding site [chemical binding]; other site 222523006399 citrylCoA binding site [chemical binding]; other site 222523006400 oxalacetate/citrate binding site [chemical binding]; other site 222523006401 catalytic triad [active] 222523006402 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 222523006403 2-methylcitrate dehydratase; Region: prpD; TIGR02330 222523006404 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 222523006405 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 222523006406 tetramer interface [polypeptide binding]; other site 222523006407 active site 222523006408 Mg2+/Mn2+ binding site [ion binding]; other site 222523006409 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 222523006410 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 222523006411 active site 222523006412 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 222523006413 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 222523006414 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 222523006415 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 222523006416 tetrameric interface [polypeptide binding]; other site 222523006417 NAD binding site [chemical binding]; other site 222523006418 catalytic residues [active] 222523006419 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 222523006420 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 222523006421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 222523006422 substrate binding site [chemical binding]; other site 222523006423 oxyanion hole (OAH) forming residues; other site 222523006424 trimer interface [polypeptide binding]; other site 222523006425 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 222523006426 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 222523006427 exonuclease SbcD; Region: sbcd; TIGR00619 222523006428 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 222523006429 active site 222523006430 metal binding site [ion binding]; metal-binding site 222523006431 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 222523006432 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 222523006433 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 222523006434 Walker A/P-loop; other site 222523006435 ATP binding site [chemical binding]; other site 222523006436 Q-loop/lid; other site 222523006437 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 222523006438 ABC transporter signature motif; other site 222523006439 Walker B; other site 222523006440 D-loop; other site 222523006441 H-loop/switch region; other site 222523006442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523006443 dimerization interface [polypeptide binding]; other site 222523006444 putative DNA binding site [nucleotide binding]; other site 222523006445 putative Zn2+ binding site [ion binding]; other site 222523006446 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 222523006447 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 222523006448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006449 putative substrate translocation pore; other site 222523006450 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 222523006451 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 222523006452 putative NAD(P) binding site [chemical binding]; other site 222523006453 active site 222523006454 isochorismate synthase DhbC; Validated; Region: PRK06923 222523006455 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 222523006456 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 222523006457 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 222523006458 acyl-activating enzyme (AAE) consensus motif; other site 222523006459 active site 222523006460 AMP binding site [chemical binding]; other site 222523006461 substrate binding site [chemical binding]; other site 222523006462 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 222523006463 hydrophobic substrate binding pocket; other site 222523006464 Isochorismatase family; Region: Isochorismatase; pfam00857 222523006465 active site 222523006466 conserved cis-peptide bond; other site 222523006467 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 222523006468 Condensation domain; Region: Condensation; pfam00668 222523006469 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 222523006470 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 222523006471 acyl-activating enzyme (AAE) consensus motif; other site 222523006472 AMP binding site [chemical binding]; other site 222523006473 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 222523006474 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 222523006475 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 222523006476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 222523006477 acyl-activating enzyme (AAE) consensus motif; other site 222523006478 AMP binding site [chemical binding]; other site 222523006479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 222523006480 MbtH-like protein; Region: MbtH; cl01279 222523006481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006482 putative transporter; Provisional; Region: PRK10504 222523006483 putative substrate translocation pore; other site 222523006484 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 222523006485 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 222523006486 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 222523006487 IHF dimer interface [polypeptide binding]; other site 222523006488 IHF - DNA interface [nucleotide binding]; other site 222523006489 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 222523006490 DinB family; Region: DinB; cl17821 222523006491 DinB superfamily; Region: DinB_2; pfam12867 222523006492 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 222523006493 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 222523006494 active site 222523006495 catalytic triad [active] 222523006496 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 222523006497 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 222523006498 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 222523006499 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523006500 RNA binding surface [nucleotide binding]; other site 222523006501 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 222523006502 probable active site [active] 222523006503 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 222523006504 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 222523006505 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 222523006506 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 222523006507 active site 222523006508 dimer interface [polypeptide binding]; other site 222523006509 motif 1; other site 222523006510 motif 2; other site 222523006511 motif 3; other site 222523006512 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 222523006513 anticodon binding site; other site 222523006514 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523006515 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523006516 Walker A/P-loop; other site 222523006517 ATP binding site [chemical binding]; other site 222523006518 Q-loop/lid; other site 222523006519 ABC transporter signature motif; other site 222523006520 Walker B; other site 222523006521 D-loop; other site 222523006522 H-loop/switch region; other site 222523006523 FtsX-like permease family; Region: FtsX; pfam02687 222523006524 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523006525 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523006526 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523006527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006528 putative substrate translocation pore; other site 222523006529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 222523006530 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 222523006531 pyruvate oxidase; Provisional; Region: PRK08611 222523006532 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 222523006533 PYR/PP interface [polypeptide binding]; other site 222523006534 dimer interface [polypeptide binding]; other site 222523006535 tetramer interface [polypeptide binding]; other site 222523006536 TPP binding site [chemical binding]; other site 222523006537 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 222523006538 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 222523006539 TPP-binding site [chemical binding]; other site 222523006540 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 222523006541 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 222523006542 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523006543 S-adenosylmethionine binding site [chemical binding]; other site 222523006544 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 222523006545 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 222523006546 Type II/IV secretion system protein; Region: T2SE; pfam00437 222523006547 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523006548 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 222523006549 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 222523006550 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 222523006551 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 222523006552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006553 Coenzyme A binding pocket [chemical binding]; other site 222523006554 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523006555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523006556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523006557 MMPL family; Region: MMPL; pfam03176 222523006558 MMPL family; Region: MMPL; pfam03176 222523006559 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 222523006560 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 222523006561 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 222523006562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006563 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523006564 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523006565 Coenzyme A binding pocket [chemical binding]; other site 222523006566 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523006567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006568 Coenzyme A binding pocket [chemical binding]; other site 222523006569 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 222523006570 putative acetyltransferase YhhY; Provisional; Region: PRK10140 222523006571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006572 Coenzyme A binding pocket [chemical binding]; other site 222523006573 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 222523006574 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 222523006575 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523006576 protoporphyrinogen oxidase; Provisional; Region: PRK12416 222523006577 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 222523006578 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523006579 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523006580 Cold-inducible protein YdjO; Region: YdjO; pfam14169 222523006581 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 222523006582 DNA-binding site [nucleotide binding]; DNA binding site 222523006583 RNA-binding motif; other site 222523006584 CAAX protease self-immunity; Region: Abi; pfam02517 222523006585 AAA domain; Region: AAA_17; pfam13207 222523006586 AAA domain; Region: AAA_18; pfam13238 222523006587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 222523006588 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523006589 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 222523006590 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523006591 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 222523006592 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523006593 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523006594 active site 222523006595 motif I; other site 222523006596 motif II; other site 222523006597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523006598 hypothetical protein; Provisional; Region: PRK06770 222523006599 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523006600 MarR family; Region: MarR_2; cl17246 222523006601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006602 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 222523006603 putative substrate translocation pore; other site 222523006604 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523006605 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523006606 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523006607 dimerization interface [polypeptide binding]; other site 222523006608 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 222523006609 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 222523006610 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 222523006611 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 222523006612 active site 222523006613 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 222523006614 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 222523006615 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523006616 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523006617 dimerization interface [polypeptide binding]; other site 222523006618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523006619 Probable transposase; Region: OrfB_IS605; pfam01385 222523006620 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 222523006621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 222523006622 MOSC domain; Region: MOSC; pfam03473 222523006623 3-alpha domain; Region: 3-alpha; pfam03475 222523006624 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523006626 Coenzyme A binding pocket [chemical binding]; other site 222523006627 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 222523006628 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523006629 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523006630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523006631 Walker A/P-loop; other site 222523006632 ATP binding site [chemical binding]; other site 222523006633 Q-loop/lid; other site 222523006634 ABC transporter signature motif; other site 222523006635 Walker B; other site 222523006636 D-loop; other site 222523006637 H-loop/switch region; other site 222523006638 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523006639 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523006640 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 222523006641 Walker A/P-loop; other site 222523006642 ATP binding site [chemical binding]; other site 222523006643 Q-loop/lid; other site 222523006644 ABC transporter signature motif; other site 222523006645 Walker B; other site 222523006646 D-loop; other site 222523006647 H-loop/switch region; other site 222523006648 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523006649 Herpes virus U44 protein; Region: Herpes_U44; pfam04533 222523006650 LysE type translocator; Region: LysE; cl00565 222523006651 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 222523006652 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523006653 non-specific DNA binding site [nucleotide binding]; other site 222523006654 salt bridge; other site 222523006655 sequence-specific DNA binding site [nucleotide binding]; other site 222523006656 Cupin domain; Region: Cupin_2; pfam07883 222523006657 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 222523006658 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 222523006659 BclB C-terminal domain; Region: exospore_TM; TIGR03721 222523006660 Cupin; Region: Cupin_1; smart00835 222523006661 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 222523006662 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 222523006663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523006664 S-adenosylmethionine binding site [chemical binding]; other site 222523006665 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 222523006666 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 222523006667 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 222523006668 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 222523006669 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 222523006670 active site 222523006671 P-loop; other site 222523006672 phosphorylation site [posttranslational modification] 222523006673 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 222523006674 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 222523006675 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 222523006676 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 222523006677 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 222523006678 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 222523006679 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 222523006680 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523006681 catalytic residue [active] 222523006682 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 222523006683 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 222523006684 tetramer interface [polypeptide binding]; other site 222523006685 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523006686 catalytic residue [active] 222523006687 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523006688 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523006689 putative DNA binding site [nucleotide binding]; other site 222523006690 putative Zn2+ binding site [ion binding]; other site 222523006691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523006693 putative substrate translocation pore; other site 222523006694 Uncharacterized conserved protein [Function unknown]; Region: COG3339 222523006695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523006696 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 222523006697 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 222523006698 ATP binding site [chemical binding]; other site 222523006699 Mg++ binding site [ion binding]; other site 222523006700 motif III; other site 222523006701 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523006702 nucleotide binding region [chemical binding]; other site 222523006703 ATP-binding site [chemical binding]; other site 222523006704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523006705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523006706 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523006707 putative substrate translocation pore; other site 222523006708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 222523006709 FtsX-like permease family; Region: FtsX; pfam02687 222523006710 FtsX-like permease family; Region: FtsX; pfam02687 222523006711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523006712 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523006713 Walker A/P-loop; other site 222523006714 ATP binding site [chemical binding]; other site 222523006715 Q-loop/lid; other site 222523006716 ABC transporter signature motif; other site 222523006717 Walker B; other site 222523006718 D-loop; other site 222523006719 H-loop/switch region; other site 222523006720 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523006721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523006722 S-adenosylmethionine binding site [chemical binding]; other site 222523006723 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 222523006724 dimer interface [polypeptide binding]; other site 222523006725 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523006726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523006727 S-adenosylmethionine binding site [chemical binding]; other site 222523006728 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 222523006729 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 222523006730 dimer interface [polypeptide binding]; other site 222523006731 PYR/PP interface [polypeptide binding]; other site 222523006732 TPP binding site [chemical binding]; other site 222523006733 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 222523006734 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 222523006735 TPP-binding site [chemical binding]; other site 222523006736 dimer interface [polypeptide binding]; other site 222523006737 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523006738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523006739 putative DNA binding site [nucleotide binding]; other site 222523006740 putative Zn2+ binding site [ion binding]; other site 222523006741 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523006742 catalytic core [active] 222523006743 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523006744 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 222523006745 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 222523006746 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 222523006747 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 222523006748 metal binding site [ion binding]; metal-binding site 222523006749 dimer interface [polypeptide binding]; other site 222523006750 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 222523006751 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523006752 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 222523006753 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 222523006754 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 222523006755 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 222523006756 active site 222523006757 catalytic triad [active] 222523006758 oxyanion hole [active] 222523006759 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 222523006760 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523006761 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 222523006762 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523006763 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 222523006764 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523006765 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523006766 DNA binding residues [nucleotide binding] 222523006767 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523006768 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523006769 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523006770 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523006771 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523006772 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523006773 beta-lactamase TEM; Provisional; Region: PRK15442 222523006774 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 222523006775 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 222523006776 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523006777 putative active site [active] 222523006778 putative metal binding site [ion binding]; other site 222523006779 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523006780 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 222523006781 Walker A/P-loop; other site 222523006782 ATP binding site [chemical binding]; other site 222523006783 Q-loop/lid; other site 222523006784 ABC transporter signature motif; other site 222523006785 Walker B; other site 222523006786 D-loop; other site 222523006787 H-loop/switch region; other site 222523006788 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 222523006789 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 222523006790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523006791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523006792 Protein of unknown function (DUF523); Region: DUF523; pfam04463 222523006793 Uncharacterized conserved protein [Function unknown]; Region: COG3272 222523006794 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 222523006795 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 222523006796 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 222523006797 FAD binding site [chemical binding]; other site 222523006798 homotetramer interface [polypeptide binding]; other site 222523006799 substrate binding pocket [chemical binding]; other site 222523006800 catalytic base [active] 222523006801 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 222523006802 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 222523006803 ATP-grasp domain; Region: ATP-grasp_4; cl17255 222523006804 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 222523006805 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 222523006806 carboxyltransferase (CT) interaction site; other site 222523006807 biotinylation site [posttranslational modification]; other site 222523006808 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 222523006809 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 222523006810 active site 222523006811 catalytic residues [active] 222523006812 metal binding site [ion binding]; metal-binding site 222523006813 enoyl-CoA hydratase; Provisional; Region: PRK07657 222523006814 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 222523006815 substrate binding site [chemical binding]; other site 222523006816 oxyanion hole (OAH) forming residues; other site 222523006817 trimer interface [polypeptide binding]; other site 222523006818 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 222523006819 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 222523006820 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 222523006821 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 222523006822 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 222523006823 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 222523006824 acyl-activating enzyme (AAE) consensus motif; other site 222523006825 putative AMP binding site [chemical binding]; other site 222523006826 putative active site [active] 222523006827 putative CoA binding site [chemical binding]; other site 222523006828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 222523006829 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006830 Coenzyme A binding pocket [chemical binding]; other site 222523006831 hypothetical protein; Provisional; Region: PRK08233 222523006832 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 222523006833 active site 222523006834 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523006835 DinB family; Region: DinB; cl17821 222523006836 DinB superfamily; Region: DinB_2; pfam12867 222523006837 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 222523006838 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523006839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523006840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523006841 dimer interface [polypeptide binding]; other site 222523006842 phosphorylation site [posttranslational modification] 222523006843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523006844 ATP binding site [chemical binding]; other site 222523006845 Mg2+ binding site [ion binding]; other site 222523006846 G-X-G motif; other site 222523006847 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523006848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523006849 active site 222523006850 phosphorylation site [posttranslational modification] 222523006851 intermolecular recognition site; other site 222523006852 dimerization interface [polypeptide binding]; other site 222523006853 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523006854 DNA binding site [nucleotide binding] 222523006855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523006856 Zn2+ binding site [ion binding]; other site 222523006857 Mg2+ binding site [ion binding]; other site 222523006858 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 222523006859 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 222523006860 NADH(P)-binding; Region: NAD_binding_10; pfam13460 222523006861 NAD binding site [chemical binding]; other site 222523006862 substrate binding site [chemical binding]; other site 222523006863 putative active site [active] 222523006864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523006865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006866 Coenzyme A binding pocket [chemical binding]; other site 222523006867 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523006868 Coenzyme A binding pocket [chemical binding]; other site 222523006869 ribonucleotide-diphosphate reductase subunit alpha; Provisional; Region: PRK12365 222523006870 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 222523006871 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 222523006872 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 222523006873 active site 222523006874 Zn binding site [ion binding]; other site 222523006875 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 222523006876 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 222523006877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 222523006878 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523006879 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523006880 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 222523006881 putative hydrophobic ligand binding site [chemical binding]; other site 222523006882 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523006883 AAA domain; Region: AAA_21; pfam13304 222523006884 Walker A/P-loop; other site 222523006885 ATP binding site [chemical binding]; other site 222523006886 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523006887 ABC transporter signature motif; other site 222523006888 Walker B; other site 222523006889 D-loop; other site 222523006890 H-loop/switch region; other site 222523006891 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 222523006892 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 222523006893 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 222523006894 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523006895 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523006896 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523006897 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523006898 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 222523006899 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523006900 DNA binding residues [nucleotide binding] 222523006901 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 222523006902 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 222523006903 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523006904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523006905 putative substrate translocation pore; other site 222523006906 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 222523006907 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 222523006908 active site 222523006909 ATP binding site [chemical binding]; other site 222523006910 substrate binding site [chemical binding]; other site 222523006911 activation loop (A-loop); other site 222523006912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 222523006913 S-adenosylmethionine binding site [chemical binding]; other site 222523006914 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523006915 Phosphotransferase enzyme family; Region: APH; pfam01636 222523006916 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523006917 active site 222523006918 substrate binding site [chemical binding]; other site 222523006919 ATP binding site [chemical binding]; other site 222523006920 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 222523006921 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523006922 Walker A/P-loop; other site 222523006923 ATP binding site [chemical binding]; other site 222523006924 Q-loop/lid; other site 222523006925 ABC transporter signature motif; other site 222523006926 Walker B; other site 222523006927 D-loop; other site 222523006928 H-loop/switch region; other site 222523006929 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523006930 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 222523006931 active site 222523006932 ATP binding site [chemical binding]; other site 222523006933 substrate binding site [chemical binding]; other site 222523006934 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 222523006935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523006936 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 222523006937 Zn binding site [ion binding]; other site 222523006938 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 222523006939 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 222523006940 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523006941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523006942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523006943 homodimer interface [polypeptide binding]; other site 222523006944 catalytic residue [active] 222523006945 Probable transposase; Region: OrfB_IS605; pfam01385 222523006946 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523006947 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 222523006948 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 222523006949 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 222523006950 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 222523006951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 222523006952 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 222523006953 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 222523006954 putative NAD(P) binding site [chemical binding]; other site 222523006955 Predicted membrane protein [Function unknown]; Region: COG2323 222523006956 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523006957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523006958 S-adenosylmethionine binding site [chemical binding]; other site 222523006959 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 222523006960 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 222523006961 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523006962 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523006963 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523006964 S-adenosylmethionine binding site [chemical binding]; other site 222523006965 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 222523006966 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 222523006967 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 222523006968 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 222523006969 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523006970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523006971 active site 222523006972 phosphorylation site [posttranslational modification] 222523006973 intermolecular recognition site; other site 222523006974 dimerization interface [polypeptide binding]; other site 222523006975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523006976 DNA binding site [nucleotide binding] 222523006977 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523006978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 222523006979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523006980 ATP binding site [chemical binding]; other site 222523006981 Mg2+ binding site [ion binding]; other site 222523006982 G-X-G motif; other site 222523006983 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 222523006984 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523006985 ABC transporter; Region: ABC_tran_2; pfam12848 222523006986 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523006987 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523006988 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523006989 Walker A/P-loop; other site 222523006990 ATP binding site [chemical binding]; other site 222523006991 Q-loop/lid; other site 222523006992 ABC transporter signature motif; other site 222523006993 Walker B; other site 222523006994 D-loop; other site 222523006995 H-loop/switch region; other site 222523006996 FtsX-like permease family; Region: FtsX; pfam02687 222523006997 hypothetical protein; Provisional; Region: PRK06760 222523006998 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 222523006999 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 222523007000 homoserine dehydrogenase; Validated; Region: PRK06813 222523007001 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 222523007002 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523007003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523007004 DNA-binding site [nucleotide binding]; DNA binding site 222523007005 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523007006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007007 homodimer interface [polypeptide binding]; other site 222523007008 catalytic residue [active] 222523007009 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 222523007010 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 222523007011 ATP-grasp domain; Region: ATP-grasp_4; cl17255 222523007012 Putative transcription activator [Transcription]; Region: TenA; COG0819 222523007013 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 222523007014 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523007015 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 222523007016 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 222523007017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007018 Coenzyme A binding pocket [chemical binding]; other site 222523007019 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523007020 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 222523007021 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 222523007022 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 222523007023 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 222523007024 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 222523007025 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 222523007026 Protein of unknown function; Region: DUF3658; pfam12395 222523007027 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 222523007028 Cytochrome P450; Region: p450; cl12078 222523007029 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007030 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523007031 putative substrate translocation pore; other site 222523007032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007033 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 222523007034 trimer interface [polypeptide binding]; other site 222523007035 active site 222523007036 substrate binding site [chemical binding]; other site 222523007037 CoA binding site [chemical binding]; other site 222523007038 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 222523007039 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523007040 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523007041 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 222523007042 Cytochrome P450; Region: p450; cl12078 222523007043 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 222523007044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523007045 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523007046 active site 222523007047 motif I; other site 222523007048 motif II; other site 222523007049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523007050 PAS domain S-box; Region: sensory_box; TIGR00229 222523007051 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523007052 putative active site [active] 222523007053 heme pocket [chemical binding]; other site 222523007054 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 222523007055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523007056 dimer interface [polypeptide binding]; other site 222523007057 phosphorylation site [posttranslational modification] 222523007058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523007059 ATP binding site [chemical binding]; other site 222523007060 Mg2+ binding site [ion binding]; other site 222523007061 G-X-G motif; other site 222523007062 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523007063 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523007064 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523007065 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 222523007066 glycosyltransferase, MGT family; Region: MGT; TIGR01426 222523007067 active site 222523007068 TDP-binding site; other site 222523007069 acceptor substrate-binding pocket; other site 222523007070 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 222523007071 aspartate racemase; Region: asp_race; TIGR00035 222523007072 hypothetical protein; Provisional; Region: PRK13661 222523007073 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 222523007074 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 222523007075 Walker A/P-loop; other site 222523007076 ATP binding site [chemical binding]; other site 222523007077 Q-loop/lid; other site 222523007078 ABC transporter signature motif; other site 222523007079 Walker B; other site 222523007080 D-loop; other site 222523007081 H-loop/switch region; other site 222523007082 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 222523007083 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 222523007084 Walker A/P-loop; other site 222523007085 ATP binding site [chemical binding]; other site 222523007086 Q-loop/lid; other site 222523007087 ABC transporter signature motif; other site 222523007088 Walker B; other site 222523007089 D-loop; other site 222523007090 H-loop/switch region; other site 222523007091 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 222523007092 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 222523007093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523007094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523007095 dimer interface [polypeptide binding]; other site 222523007096 phosphorylation site [posttranslational modification] 222523007097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523007098 ATP binding site [chemical binding]; other site 222523007099 Mg2+ binding site [ion binding]; other site 222523007100 G-X-G motif; other site 222523007101 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 222523007102 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 222523007103 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523007104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523007105 active site 222523007106 phosphorylation site [posttranslational modification] 222523007107 intermolecular recognition site; other site 222523007108 dimerization interface [polypeptide binding]; other site 222523007109 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523007110 DNA binding site [nucleotide binding] 222523007111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523007112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523007113 dimerization interface [polypeptide binding]; other site 222523007114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523007115 dimer interface [polypeptide binding]; other site 222523007116 phosphorylation site [posttranslational modification] 222523007117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523007118 ATP binding site [chemical binding]; other site 222523007119 Mg2+ binding site [ion binding]; other site 222523007120 G-X-G motif; other site 222523007121 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523007122 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 222523007123 NAD(P) binding site [chemical binding]; other site 222523007124 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 222523007125 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 222523007126 active site 222523007127 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523007128 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523007129 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523007130 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 222523007131 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 222523007132 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523007133 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523007134 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 222523007135 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 222523007136 classical (c) SDRs; Region: SDR_c; cd05233 222523007137 NAD(P) binding site [chemical binding]; other site 222523007138 active site 222523007139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007140 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523007141 putative substrate translocation pore; other site 222523007142 VanZ like family; Region: VanZ; pfam04892 222523007143 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 222523007144 EDD domain protein, DegV family; Region: DegV; TIGR00762 222523007145 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 222523007146 Putative amidotransferase; Region: DUF4066; pfam13278 222523007147 conserved cys residue [active] 222523007148 Predicted transcriptional regulator [Transcription]; Region: COG2378 222523007149 HTH domain; Region: HTH_11; pfam08279 222523007150 WYL domain; Region: WYL; pfam13280 222523007151 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 222523007152 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 222523007153 conserved cys residue [active] 222523007154 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 222523007155 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 222523007156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007157 catalytic residue [active] 222523007158 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523007159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523007160 Cytochrome P450; Region: p450; cl12078 222523007161 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 222523007162 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 222523007163 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523007164 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 222523007165 DNA binding residues [nucleotide binding] 222523007166 putative dimer interface [polypeptide binding]; other site 222523007167 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523007168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007169 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007170 Coenzyme A binding pocket [chemical binding]; other site 222523007171 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 222523007172 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 222523007173 active site 222523007174 catalytic site [active] 222523007175 metal binding site [ion binding]; metal-binding site 222523007176 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 222523007177 active site 222523007178 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 222523007179 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523007180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523007181 DNA-binding site [nucleotide binding]; DNA binding site 222523007182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523007183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007184 homodimer interface [polypeptide binding]; other site 222523007185 catalytic residue [active] 222523007186 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523007187 EamA-like transporter family; Region: EamA; pfam00892 222523007188 EamA-like transporter family; Region: EamA; pfam00892 222523007189 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 222523007190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007191 Coenzyme A binding pocket [chemical binding]; other site 222523007192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 222523007193 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 222523007194 nudix motif; other site 222523007195 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 222523007196 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 222523007197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007198 putative substrate translocation pore; other site 222523007199 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 222523007200 nudix motif; other site 222523007201 DNA polymerase III subunit beta; Validated; Region: PRK06673 222523007202 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 222523007203 putative DNA binding surface [nucleotide binding]; other site 222523007204 dimer interface [polypeptide binding]; other site 222523007205 beta-clamp/clamp loader binding surface; other site 222523007206 beta-clamp/translesion DNA polymerase binding surface; other site 222523007207 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 222523007208 putative active site [active] 222523007209 nucleotide binding site [chemical binding]; other site 222523007210 nudix motif; other site 222523007211 putative metal binding site [ion binding]; other site 222523007212 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523007213 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 222523007214 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 222523007215 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 222523007216 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 222523007217 homotrimer interaction site [polypeptide binding]; other site 222523007218 putative active site [active] 222523007219 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 222523007220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007221 Coenzyme A binding pocket [chemical binding]; other site 222523007222 metal-dependent hydrolase; Provisional; Region: PRK13291 222523007223 DinB superfamily; Region: DinB_2; pfam12867 222523007224 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007225 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523007226 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 222523007227 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523007228 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 222523007229 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 222523007230 GIY-YIG motif/motif A; other site 222523007231 active site 222523007232 catalytic site [active] 222523007233 putative DNA binding site [nucleotide binding]; other site 222523007234 metal binding site [ion binding]; metal-binding site 222523007235 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007237 Coenzyme A binding pocket [chemical binding]; other site 222523007238 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 222523007239 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 222523007240 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 222523007241 active site 222523007242 ATP binding site [chemical binding]; other site 222523007243 substrate binding site [chemical binding]; other site 222523007244 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 222523007245 nudix motif; other site 222523007246 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 222523007247 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 222523007248 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 222523007249 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 222523007250 MepB protein; Region: MepB; pfam08877 222523007251 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 222523007252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523007253 motif II; other site 222523007254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523007255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523007256 active site 222523007257 phosphorylation site [posttranslational modification] 222523007258 intermolecular recognition site; other site 222523007259 dimerization interface [polypeptide binding]; other site 222523007260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523007261 DNA binding site [nucleotide binding] 222523007262 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 222523007263 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523007264 dimerization interface [polypeptide binding]; other site 222523007265 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523007266 dimer interface [polypeptide binding]; other site 222523007267 phosphorylation site [posttranslational modification] 222523007268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523007269 ATP binding site [chemical binding]; other site 222523007270 Mg2+ binding site [ion binding]; other site 222523007271 G-X-G motif; other site 222523007272 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 222523007273 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 222523007274 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523007275 Spore germination protein; Region: Spore_permease; cl17796 222523007276 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523007277 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523007278 Walker A/P-loop; other site 222523007279 ATP binding site [chemical binding]; other site 222523007280 Q-loop/lid; other site 222523007281 ABC transporter signature motif; other site 222523007282 Walker B; other site 222523007283 D-loop; other site 222523007284 H-loop/switch region; other site 222523007285 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523007286 FtsX-like permease family; Region: FtsX; pfam02687 222523007287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 222523007288 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 222523007289 active site 222523007290 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 222523007291 carbohydrate binding site [chemical binding]; other site 222523007292 pullulanase, type I; Region: pulA_typeI; TIGR02104 222523007293 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 222523007294 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 222523007295 Ca binding site [ion binding]; other site 222523007296 active site 222523007297 catalytic site [active] 222523007298 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 222523007299 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 222523007300 active site 222523007301 Zn binding site [ion binding]; other site 222523007302 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 222523007303 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 222523007304 putative metal binding site [ion binding]; other site 222523007305 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523007306 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 222523007307 SecY translocase; Region: SecY; pfam00344 222523007308 DnaA N-terminal domain; Region: DnaA_N; pfam11638 222523007309 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 222523007310 EamA-like transporter family; Region: EamA; pfam00892 222523007311 EamA-like transporter family; Region: EamA; pfam00892 222523007312 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523007313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523007314 DNA-binding site [nucleotide binding]; DNA binding site 222523007315 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523007316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007317 homodimer interface [polypeptide binding]; other site 222523007318 catalytic residue [active] 222523007319 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523007320 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 222523007321 putative NAD(P) binding site [chemical binding]; other site 222523007322 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523007323 TAP-like protein; Region: Abhydrolase_4; pfam08386 222523007324 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 222523007325 Mg binding site [ion binding]; other site 222523007326 nucleotide binding site [chemical binding]; other site 222523007327 putative protofilament interface [polypeptide binding]; other site 222523007328 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 222523007329 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 222523007330 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523007331 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 222523007332 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 222523007333 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 222523007334 germination protein YpeB; Region: spore_YpeB; TIGR02889 222523007335 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 222523007336 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 222523007337 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 222523007338 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 222523007339 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523007340 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523007341 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 222523007342 arylformamidase; Region: trp_arylform; TIGR03035 222523007343 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 222523007344 kynureninase; Region: kynureninase; TIGR01814 222523007345 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523007346 catalytic residue [active] 222523007347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523007348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523007349 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 222523007350 nudix motif; other site 222523007351 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 222523007352 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 222523007353 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 222523007354 GAF domain; Region: GAF; pfam01590 222523007355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523007356 Walker A motif; other site 222523007357 ATP binding site [chemical binding]; other site 222523007358 Walker B motif; other site 222523007359 arginine finger; other site 222523007360 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 222523007361 NIPSNAP; Region: NIPSNAP; pfam07978 222523007362 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 222523007363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007364 Coenzyme A binding pocket [chemical binding]; other site 222523007365 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 222523007366 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 222523007367 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 222523007368 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 222523007369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523007370 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523007371 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 222523007372 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 222523007373 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 222523007374 E3 interaction surface; other site 222523007375 lipoyl attachment site [posttranslational modification]; other site 222523007376 e3 binding domain; Region: E3_binding; pfam02817 222523007377 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 222523007378 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 222523007379 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 222523007380 alpha subunit interface [polypeptide binding]; other site 222523007381 TPP binding site [chemical binding]; other site 222523007382 heterodimer interface [polypeptide binding]; other site 222523007383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523007384 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 222523007385 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 222523007386 tetramer interface [polypeptide binding]; other site 222523007387 TPP-binding site [chemical binding]; other site 222523007388 heterodimer interface [polypeptide binding]; other site 222523007389 phosphorylation loop region [posttranslational modification] 222523007390 DinB superfamily; Region: DinB_2; pfam12867 222523007391 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 222523007392 short chain dehydrogenase; Provisional; Region: PRK06914 222523007393 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 222523007394 NADP binding site [chemical binding]; other site 222523007395 active site 222523007396 steroid binding site; other site 222523007397 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 222523007398 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 222523007399 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 222523007400 nudix motif; other site 222523007401 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 222523007402 Protein phosphatase 2C; Region: PP2C_2; pfam13672 222523007403 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 222523007404 nucleotide binding site/active site [active] 222523007405 HIT family signature motif; other site 222523007406 catalytic residue [active] 222523007407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523007408 dimer interface [polypeptide binding]; other site 222523007409 conserved gate region; other site 222523007410 putative PBP binding loops; other site 222523007411 ABC-ATPase subunit interface; other site 222523007412 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 222523007413 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 222523007414 Walker A/P-loop; other site 222523007415 ATP binding site [chemical binding]; other site 222523007416 Q-loop/lid; other site 222523007417 ABC transporter signature motif; other site 222523007418 Walker B; other site 222523007419 D-loop; other site 222523007420 H-loop/switch region; other site 222523007421 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 222523007422 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 222523007423 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 222523007424 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 222523007425 Clp protease; Region: CLP_protease; pfam00574 222523007426 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 222523007427 oligomer interface [polypeptide binding]; other site 222523007428 active site residues [active] 222523007429 RNA polymerase factor sigma-70; Validated; Region: PRK06704 222523007430 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523007431 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 222523007432 DNA binding residues [nucleotide binding] 222523007433 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 222523007434 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 222523007435 catalytic loop [active] 222523007436 iron binding site [ion binding]; other site 222523007437 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 222523007438 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523007439 active site 222523007440 dimer interface [polypeptide binding]; other site 222523007441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007442 Coenzyme A binding pocket [chemical binding]; other site 222523007443 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 222523007444 Chitin binding domain; Region: Chitin_bind_3; pfam03067 222523007445 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 222523007446 Interdomain contacts; other site 222523007447 Cytokine receptor motif; other site 222523007448 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 222523007449 Interdomain contacts; other site 222523007450 Cytokine receptor motif; other site 222523007451 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 222523007452 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 222523007453 glycosyltransferase, MGT family; Region: MGT; TIGR01426 222523007454 active site 222523007455 TDP-binding site; other site 222523007456 acceptor substrate-binding pocket; other site 222523007457 homodimer interface [polypeptide binding]; other site 222523007458 Uncharacterized conserved protein [Function unknown]; Region: COG1262 222523007459 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 222523007460 topology modulation protein; Reviewed; Region: PRK08118 222523007461 AAA domain; Region: AAA_17; pfam13207 222523007462 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523007463 active site 222523007464 substrate binding site [chemical binding]; other site 222523007465 ATP binding site [chemical binding]; other site 222523007466 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 222523007467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523007468 S-adenosylmethionine binding site [chemical binding]; other site 222523007469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 222523007470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007471 Coenzyme A binding pocket [chemical binding]; other site 222523007472 S-layer homology domain; Region: SLH; pfam00395 222523007473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007474 Coenzyme A binding pocket [chemical binding]; other site 222523007475 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 222523007476 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 222523007477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007478 Coenzyme A binding pocket [chemical binding]; other site 222523007479 Protein of unknown function (DUF952); Region: DUF952; pfam06108 222523007480 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 222523007481 Part of AAA domain; Region: AAA_19; pfam13245 222523007482 Family description; Region: UvrD_C_2; pfam13538 222523007483 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523007484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523007485 S-adenosylmethionine binding site [chemical binding]; other site 222523007486 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 222523007487 putative active site pocket [active] 222523007488 dimerization interface [polypeptide binding]; other site 222523007489 putative catalytic residue [active] 222523007490 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 222523007491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523007492 ATP binding site [chemical binding]; other site 222523007493 putative Mg++ binding site [ion binding]; other site 222523007494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523007495 nucleotide binding region [chemical binding]; other site 222523007496 ATP-binding site [chemical binding]; other site 222523007497 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 222523007498 HRDC domain; Region: HRDC; pfam00570 222523007499 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 222523007500 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 222523007501 active site 222523007502 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 222523007503 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 222523007504 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 222523007505 active site 222523007506 metal binding site [ion binding]; metal-binding site 222523007507 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 222523007508 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 222523007509 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 222523007510 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 222523007511 active site 222523007512 Zn binding site [ion binding]; other site 222523007513 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 222523007514 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 222523007515 DHHA2 domain; Region: DHHA2; pfam02833 222523007516 Chitin binding domain; Region: Chitin_bind_3; pfam03067 222523007517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523007518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007519 Coenzyme A binding pocket [chemical binding]; other site 222523007520 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 222523007521 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 222523007522 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 222523007523 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 222523007524 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 222523007525 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 222523007526 NAD(P) binding site [chemical binding]; other site 222523007527 catalytic residues [active] 222523007528 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 222523007529 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 222523007530 inhibitor site; inhibition site 222523007531 active site 222523007532 dimer interface [polypeptide binding]; other site 222523007533 catalytic residue [active] 222523007534 Proline racemase; Region: Pro_racemase; pfam05544 222523007535 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 222523007536 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 222523007537 Proline racemase; Region: Pro_racemase; pfam05544 222523007538 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 222523007539 hydroxyglutarate oxidase; Provisional; Region: PRK11728 222523007540 PAS domain; Region: PAS; smart00091 222523007541 PAS domain; Region: PAS_9; pfam13426 222523007542 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 222523007543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523007544 Walker A motif; other site 222523007545 ATP binding site [chemical binding]; other site 222523007546 Walker B motif; other site 222523007547 arginine finger; other site 222523007548 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 222523007549 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 222523007550 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 222523007551 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 222523007552 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 222523007553 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523007554 DinB superfamily; Region: DinB_2; pfam12867 222523007555 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 222523007556 DltD N-terminal region; Region: DltD_N; pfam04915 222523007557 DltD central region; Region: DltD_M; pfam04918 222523007558 DltD C-terminal region; Region: DltD_C; pfam04914 222523007559 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007561 Coenzyme A binding pocket [chemical binding]; other site 222523007562 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523007563 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523007564 peptide binding site [polypeptide binding]; other site 222523007565 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 222523007566 NlpC/P60 family; Region: NLPC_P60; pfam00877 222523007567 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 222523007568 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 222523007569 active site 222523007570 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 222523007571 DJ-1 family protein; Region: not_thiJ; TIGR01383 222523007572 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 222523007573 conserved cys residue [active] 222523007574 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 222523007575 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 222523007576 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 222523007577 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 222523007578 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 222523007579 active site 222523007580 catalytic motif [active] 222523007581 Zn binding site [ion binding]; other site 222523007582 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523007583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523007584 S-adenosylmethionine binding site [chemical binding]; other site 222523007585 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 222523007586 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 222523007587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523007588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523007589 dimerization interface [polypeptide binding]; other site 222523007590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523007591 dimer interface [polypeptide binding]; other site 222523007592 phosphorylation site [posttranslational modification] 222523007593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523007594 ATP binding site [chemical binding]; other site 222523007595 Mg2+ binding site [ion binding]; other site 222523007596 G-X-G motif; other site 222523007597 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523007598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523007599 active site 222523007600 phosphorylation site [posttranslational modification] 222523007601 intermolecular recognition site; other site 222523007602 dimerization interface [polypeptide binding]; other site 222523007603 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523007604 DNA binding site [nucleotide binding] 222523007605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523007606 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 222523007607 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 222523007608 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 222523007609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523007610 motif II; other site 222523007611 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 222523007612 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 222523007613 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 222523007614 Zn binding site [ion binding]; other site 222523007615 Probable transposase; Region: OrfB_IS605; pfam01385 222523007616 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 222523007617 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 222523007618 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 222523007619 Spore germination protein; Region: Spore_permease; cl17796 222523007620 Amino acid permease; Region: AA_permease_2; pfam13520 222523007621 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523007622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523007623 putative DNA binding site [nucleotide binding]; other site 222523007624 putative Zn2+ binding site [ion binding]; other site 222523007625 AsnC family; Region: AsnC_trans_reg; pfam01037 222523007626 EDD domain protein, DegV family; Region: DegV; TIGR00762 222523007627 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 222523007628 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 222523007629 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 222523007630 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 222523007631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007632 Coenzyme A binding pocket [chemical binding]; other site 222523007633 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 222523007634 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007636 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523007637 putative substrate translocation pore; other site 222523007638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007639 putative substrate translocation pore; other site 222523007640 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 222523007641 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 222523007642 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 222523007643 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 222523007644 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 222523007645 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 222523007646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523007648 putative substrate translocation pore; other site 222523007649 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 222523007650 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 222523007651 active site 222523007652 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 222523007653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523007654 S-adenosylmethionine binding site [chemical binding]; other site 222523007655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007656 putative substrate translocation pore; other site 222523007657 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523007658 aspartate aminotransferase; Provisional; Region: PRK07681 222523007659 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523007660 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007661 homodimer interface [polypeptide binding]; other site 222523007662 catalytic residue [active] 222523007663 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 222523007664 pantothenate kinase; Provisional; Region: PRK13317 222523007665 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 222523007666 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 222523007667 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 222523007668 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 222523007669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523007670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523007671 Walker A/P-loop; other site 222523007672 ATP binding site [chemical binding]; other site 222523007673 Q-loop/lid; other site 222523007674 ABC transporter signature motif; other site 222523007675 Walker B; other site 222523007676 D-loop; other site 222523007677 H-loop/switch region; other site 222523007678 Predicted transcriptional regulators [Transcription]; Region: COG1725 222523007679 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523007680 DNA-binding site [nucleotide binding]; DNA binding site 222523007681 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 222523007682 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 222523007683 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 222523007684 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 222523007685 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 222523007686 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 222523007687 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 222523007688 Domain of unknown function DUF20; Region: UPF0118; pfam01594 222523007689 HNH endonuclease; Region: HNH_5; pfam14279 222523007690 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 222523007691 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 222523007692 active site 222523007693 dimer interface [polypeptide binding]; other site 222523007694 non-prolyl cis peptide bond; other site 222523007695 insertion regions; other site 222523007696 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 222523007697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 222523007698 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 222523007699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523007700 substrate binding pocket [chemical binding]; other site 222523007701 membrane-bound complex binding site; other site 222523007702 hinge residues; other site 222523007703 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 222523007704 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 222523007705 Walker A/P-loop; other site 222523007706 ATP binding site [chemical binding]; other site 222523007707 Q-loop/lid; other site 222523007708 ABC transporter signature motif; other site 222523007709 Walker B; other site 222523007710 D-loop; other site 222523007711 H-loop/switch region; other site 222523007712 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523007713 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523007714 Protein of unknown function (DUF402); Region: DUF402; pfam04167 222523007715 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 222523007716 nudix motif; other site 222523007717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 222523007718 binding surface 222523007719 TPR motif; other site 222523007720 hypothetical protein; Provisional; Region: PRK09620 222523007721 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 222523007722 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 222523007723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 222523007724 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523007725 Coenzyme A binding pocket [chemical binding]; other site 222523007726 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 222523007727 DinB superfamily; Region: DinB_2; pfam12867 222523007728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 222523007729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007730 Coenzyme A binding pocket [chemical binding]; other site 222523007731 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007732 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523007733 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 222523007734 active site 222523007735 NTP binding site [chemical binding]; other site 222523007736 metal binding triad [ion binding]; metal-binding site 222523007737 antibiotic binding site [chemical binding]; other site 222523007738 A new structural DNA glycosylase; Region: AlkD_like; cd06561 222523007739 active site 222523007740 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 222523007741 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 222523007742 NodB motif; other site 222523007743 active site 222523007744 catalytic site [active] 222523007745 Zn binding site [ion binding]; other site 222523007746 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 222523007747 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 222523007748 active site 222523007749 P-loop; other site 222523007750 phosphorylation site [posttranslational modification] 222523007751 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 222523007752 active site 222523007753 phosphorylation site [posttranslational modification] 222523007754 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 222523007755 HTH domain; Region: HTH_11; pfam08279 222523007756 Mga helix-turn-helix domain; Region: Mga; pfam05043 222523007757 PRD domain; Region: PRD; pfam00874 222523007758 PRD domain; Region: PRD; pfam00874 222523007759 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 222523007760 active site 222523007761 P-loop; other site 222523007762 phosphorylation site [posttranslational modification] 222523007763 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 222523007764 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 222523007765 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 222523007766 Sulfatase; Region: Sulfatase; pfam00884 222523007767 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 222523007768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523007769 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523007770 ABC transporter; Region: ABC_tran_2; pfam12848 222523007771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523007772 hypothetical protein; Provisional; Region: PRK06761 222523007773 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 222523007774 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 222523007775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523007776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523007777 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 222523007778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007779 Coenzyme A binding pocket [chemical binding]; other site 222523007780 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 222523007781 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 222523007782 hinge; other site 222523007783 active site 222523007784 prephenate dehydrogenase; Validated; Region: PRK06545 222523007785 prephenate dehydrogenase; Validated; Region: PRK08507 222523007786 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 222523007787 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 222523007788 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523007789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007790 homodimer interface [polypeptide binding]; other site 222523007791 catalytic residue [active] 222523007792 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 222523007793 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 222523007794 Tetramer interface [polypeptide binding]; other site 222523007795 active site 222523007796 FMN-binding site [chemical binding]; other site 222523007797 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 222523007798 Chorismate mutase type II; Region: CM_2; cl00693 222523007799 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 222523007800 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 222523007801 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 222523007802 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 222523007803 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523007804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007805 Coenzyme A binding pocket [chemical binding]; other site 222523007806 Isochorismatase family; Region: Isochorismatase; pfam00857 222523007807 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 222523007808 catalytic triad [active] 222523007809 conserved cis-peptide bond; other site 222523007810 YfzA-like protein; Region: YfzA; pfam14118 222523007811 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 222523007812 active site 222523007813 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523007814 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523007815 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 222523007816 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 222523007817 malate:quinone oxidoreductase; Validated; Region: PRK05257 222523007818 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 222523007819 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 222523007820 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 222523007821 ligand binding site [chemical binding]; other site 222523007822 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 222523007823 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 222523007824 TM-ABC transporter signature motif; other site 222523007825 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 222523007826 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 222523007827 TM-ABC transporter signature motif; other site 222523007828 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 222523007829 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 222523007830 Walker A/P-loop; other site 222523007831 ATP binding site [chemical binding]; other site 222523007832 Q-loop/lid; other site 222523007833 ABC transporter signature motif; other site 222523007834 Walker B; other site 222523007835 D-loop; other site 222523007836 H-loop/switch region; other site 222523007837 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 222523007838 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 222523007839 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 222523007840 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 222523007841 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 222523007842 putative N- and C-terminal domain interface [polypeptide binding]; other site 222523007843 putative active site [active] 222523007844 putative MgATP binding site [chemical binding]; other site 222523007845 catalytic site [active] 222523007846 metal binding site [ion binding]; metal-binding site 222523007847 putative carbohydrate binding site [chemical binding]; other site 222523007848 Cupin domain; Region: Cupin_2; pfam07883 222523007849 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 222523007850 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 222523007851 putative active site; other site 222523007852 catalytic residue [active] 222523007853 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007854 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523007855 Chorismate mutase type II; Region: CM_2; cl00693 222523007856 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523007857 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 222523007858 active site 222523007859 metal binding site [ion binding]; metal-binding site 222523007860 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 222523007861 active site 222523007862 NTP binding site [chemical binding]; other site 222523007863 metal binding triad [ion binding]; metal-binding site 222523007864 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 222523007865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007866 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523007867 putative substrate translocation pore; other site 222523007868 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523007869 putative DNA binding site [nucleotide binding]; other site 222523007870 putative Zn2+ binding site [ion binding]; other site 222523007871 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523007872 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523007873 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523007874 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 222523007875 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 222523007876 putative catalytic cysteine [active] 222523007877 gamma-glutamyl kinase; Provisional; Region: PRK05429 222523007878 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 222523007879 nucleotide binding site [chemical binding]; other site 222523007880 homotetrameric interface [polypeptide binding]; other site 222523007881 putative phosphate binding site [ion binding]; other site 222523007882 putative allosteric binding site; other site 222523007883 PUA domain; Region: PUA; pfam01472 222523007884 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 222523007885 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 222523007886 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 222523007887 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 222523007888 putative metal binding site [ion binding]; other site 222523007889 putative dimer interface [polypeptide binding]; other site 222523007890 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 222523007891 Transcriptional regulator [Transcription]; Region: IclR; COG1414 222523007892 Bacterial transcriptional regulator; Region: IclR; pfam01614 222523007893 S-methylmethionine transporter; Provisional; Region: PRK11387 222523007894 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 222523007895 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 222523007896 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 222523007897 putative di-iron ligands [ion binding]; other site 222523007898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 222523007899 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 222523007900 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 222523007901 dimer interface [polypeptide binding]; other site 222523007902 Alkaline phosphatase homologues; Region: alkPPc; smart00098 222523007903 active site 222523007904 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 222523007905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523007906 salt bridge; other site 222523007907 non-specific DNA binding site [nucleotide binding]; other site 222523007908 sequence-specific DNA binding site [nucleotide binding]; other site 222523007909 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 222523007910 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 222523007911 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 222523007912 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 222523007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 222523007914 active site 222523007915 phosphorylation site [posttranslational modification] 222523007916 intermolecular recognition site; other site 222523007917 LytTr DNA-binding domain; Region: LytTR; pfam04397 222523007918 uridine kinase; Provisional; Region: PRK07667 222523007919 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523007920 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523007921 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523007922 Coenzyme A binding pocket [chemical binding]; other site 222523007923 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523007924 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 222523007925 active site 222523007926 metal binding site [ion binding]; metal-binding site 222523007927 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 222523007928 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523007929 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523007930 MoxR-like ATPases [General function prediction only]; Region: COG0714 222523007931 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523007932 Walker A motif; other site 222523007933 ATP binding site [chemical binding]; other site 222523007934 Walker B motif; other site 222523007935 arginine finger; other site 222523007936 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 222523007937 Protein of unknown function DUF58; Region: DUF58; pfam01882 222523007938 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 222523007939 proline/glycine betaine transporter; Provisional; Region: PRK10642 222523007940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523007941 putative substrate translocation pore; other site 222523007942 acetylornithine aminotransferase; Provisional; Region: PRK02627 222523007943 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523007944 inhibitor-cofactor binding pocket; inhibition site 222523007945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523007946 catalytic residue [active] 222523007947 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 222523007948 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 222523007949 tetramer interface [polypeptide binding]; other site 222523007950 heme binding pocket [chemical binding]; other site 222523007951 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 222523007952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523007953 dimer interface [polypeptide binding]; other site 222523007954 conserved gate region; other site 222523007955 putative PBP binding loops; other site 222523007956 ABC-ATPase subunit interface; other site 222523007957 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 222523007958 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 222523007959 Walker A/P-loop; other site 222523007960 ATP binding site [chemical binding]; other site 222523007961 Q-loop/lid; other site 222523007962 ABC transporter signature motif; other site 222523007963 Walker B; other site 222523007964 D-loop; other site 222523007965 H-loop/switch region; other site 222523007966 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 222523007967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523007968 membrane-bound complex binding site; other site 222523007969 hinge residues; other site 222523007970 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 222523007971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523007972 MarR family; Region: MarR; pfam01047 222523007973 LysE type translocator; Region: LysE; pfam01810 222523007974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523007975 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523007976 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 222523007977 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 222523007978 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 222523007979 Protein of unknown function DUF58; Region: DUF58; pfam01882 222523007980 MoxR-like ATPases [General function prediction only]; Region: COG0714 222523007981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523007982 Walker A motif; other site 222523007983 ATP binding site [chemical binding]; other site 222523007984 Walker B motif; other site 222523007985 arginine finger; other site 222523007986 Uncharacterized conserved protein [Function unknown]; Region: COG1359 222523007987 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 222523007988 dimer interface [polypeptide binding]; other site 222523007989 FMN binding site [chemical binding]; other site 222523007990 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523007991 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523007992 putative DNA binding site [nucleotide binding]; other site 222523007993 putative Zn2+ binding site [ion binding]; other site 222523007994 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 222523007995 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 222523007996 G1 box; other site 222523007997 putative GEF interaction site [polypeptide binding]; other site 222523007998 GTP/Mg2+ binding site [chemical binding]; other site 222523007999 Switch I region; other site 222523008000 G2 box; other site 222523008001 G3 box; other site 222523008002 Switch II region; other site 222523008003 G4 box; other site 222523008004 G5 box; other site 222523008005 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 222523008006 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 222523008007 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 222523008008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523008009 TPR motif; other site 222523008010 binding surface 222523008011 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 222523008012 nudix motif; other site 222523008013 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 222523008014 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523008015 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523008016 Walker A/P-loop; other site 222523008017 ATP binding site [chemical binding]; other site 222523008018 Q-loop/lid; other site 222523008019 ABC transporter signature motif; other site 222523008020 Walker B; other site 222523008021 D-loop; other site 222523008022 H-loop/switch region; other site 222523008023 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 222523008024 FtsX-like permease family; Region: FtsX; pfam02687 222523008025 FtsX-like permease family; Region: FtsX; pfam02687 222523008026 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523008027 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523008028 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 222523008029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523008030 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 222523008031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523008032 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008033 Coenzyme A binding pocket [chemical binding]; other site 222523008034 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 222523008035 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 222523008036 nudix motif; other site 222523008037 EamA-like transporter family; Region: EamA; pfam00892 222523008038 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523008039 EamA-like transporter family; Region: EamA; pfam00892 222523008040 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523008041 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523008042 DNA-binding site [nucleotide binding]; DNA binding site 222523008043 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523008044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523008045 homodimer interface [polypeptide binding]; other site 222523008046 catalytic residue [active] 222523008047 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 222523008048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523008049 hypothetical protein; Validated; Region: PRK00124 222523008050 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 222523008051 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 222523008052 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 222523008053 active site 222523008054 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 222523008055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523008056 active site 222523008057 metal binding site [ion binding]; metal-binding site 222523008058 Phosphotransferase enzyme family; Region: APH; pfam01636 222523008059 active site 222523008060 substrate binding site [chemical binding]; other site 222523008061 ATP binding site [chemical binding]; other site 222523008062 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523008063 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 222523008064 active site 222523008065 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523008066 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523008067 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523008068 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523008069 Coenzyme A binding pocket [chemical binding]; other site 222523008070 lysine transporter; Provisional; Region: PRK10836 222523008071 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 222523008072 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523008073 DNA binding residues [nucleotide binding] 222523008074 dimer interface [polypeptide binding]; other site 222523008075 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 222523008076 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 222523008077 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 222523008078 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 222523008079 putative active site [active] 222523008080 nucleotide binding site [chemical binding]; other site 222523008081 nudix motif; other site 222523008082 putative metal binding site [ion binding]; other site 222523008083 Cephalosporin hydroxylase; Region: CmcI; pfam04989 222523008084 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 222523008085 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523008086 Catalytic site [active] 222523008087 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523008088 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523008089 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523008090 NAD-dependent deacetylase; Provisional; Region: PRK00481 222523008091 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 222523008092 NAD+ binding site [chemical binding]; other site 222523008093 substrate binding site [chemical binding]; other site 222523008094 Zn binding site [ion binding]; other site 222523008095 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 222523008096 putative substrate binding pocket [chemical binding]; other site 222523008097 AC domain interface; other site 222523008098 catalytic triad [active] 222523008099 AB domain interface; other site 222523008100 interchain disulfide; other site 222523008101 Predicted membrane protein [Function unknown]; Region: COG3817 222523008102 Protein of unknown function (DUF979); Region: DUF979; pfam06166 222523008103 Protein of unknown function (DUF969); Region: DUF969; pfam06149 222523008104 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 222523008105 putative active site [active] 222523008106 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 222523008107 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 222523008108 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 222523008109 Transcriptional regulator [Transcription]; Region: IclR; COG1414 222523008110 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 222523008111 Bacterial transcriptional regulator; Region: IclR; pfam01614 222523008112 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 222523008113 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523008114 Catalytic site [active] 222523008115 CutC family; Region: CutC; cl01218 222523008116 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 222523008117 stage II sporulation protein P; Region: spore_II_P; TIGR02867 222523008118 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 222523008119 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 222523008120 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 222523008121 Uncharacterized conserved protein [Function unknown]; Region: COG1434 222523008122 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 222523008123 putative active site [active] 222523008124 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523008125 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523008126 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 222523008127 Nucleoside recognition; Region: Gate; pfam07670 222523008128 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523008129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008130 Coenzyme A binding pocket [chemical binding]; other site 222523008131 Uncharacterized conserved protein [Function unknown]; Region: COG1633 222523008132 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 222523008133 dinuclear metal binding motif [ion binding]; other site 222523008134 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 222523008135 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 222523008136 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 222523008137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523008138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008139 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 222523008140 phosphoenolpyruvate synthase; Validated; Region: PRK06241 222523008141 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 222523008142 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 222523008143 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 222523008144 glycosyltransferase, MGT family; Region: MGT; TIGR01426 222523008145 active site 222523008146 TDP-binding site; other site 222523008147 acceptor substrate-binding pocket; other site 222523008148 homodimer interface [polypeptide binding]; other site 222523008149 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523008150 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 222523008151 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 222523008152 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 222523008153 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 222523008154 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 222523008155 NAD binding site [chemical binding]; other site 222523008156 catalytic Zn binding site [ion binding]; other site 222523008157 structural Zn binding site [ion binding]; other site 222523008158 YolD-like protein; Region: YolD; pfam08863 222523008159 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 222523008160 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 222523008161 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523008162 active site 222523008163 DNA binding site [nucleotide binding] 222523008164 Int/Topo IB signature motif; other site 222523008165 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523008166 active site 222523008167 DNA binding site [nucleotide binding] 222523008168 Int/Topo IB signature motif; other site 222523008169 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 222523008170 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 222523008171 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 222523008172 DNA polymerase IV; Reviewed; Region: PRK03103 222523008173 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 222523008174 active site 222523008175 DNA binding site [nucleotide binding] 222523008176 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 222523008177 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 222523008178 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 222523008179 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 222523008180 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 222523008181 putative active site [active] 222523008182 putative metal binding site [ion binding]; other site 222523008183 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 222523008184 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523008185 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523008186 TAP-like protein; Region: Abhydrolase_4; pfam08386 222523008187 Isochorismatase family; Region: Isochorismatase; pfam00857 222523008188 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 222523008189 catalytic triad [active] 222523008190 dimer interface [polypeptide binding]; other site 222523008191 conserved cis-peptide bond; other site 222523008192 Isochorismatase family; Region: Isochorismatase; pfam00857 222523008193 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 222523008194 catalytic triad [active] 222523008195 dimer interface [polypeptide binding]; other site 222523008196 conserved cis-peptide bond; other site 222523008197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 222523008198 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 222523008199 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 222523008200 active site 222523008201 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523008202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523008203 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523008204 dimerization interface [polypeptide binding]; other site 222523008205 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 222523008206 Cl binding site [ion binding]; other site 222523008207 oligomer interface [polypeptide binding]; other site 222523008208 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 222523008209 plasmid segregation protein ParM; Provisional; Region: PRK13917 222523008210 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 222523008211 Mg binding site [ion binding]; other site 222523008212 nucleotide binding site [chemical binding]; other site 222523008213 putative protofilament interface [polypeptide binding]; other site 222523008214 Heat induced stress protein YflT; Region: YflT; pfam11181 222523008215 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 222523008216 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 222523008217 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523008218 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523008219 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 222523008220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523008221 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523008222 dimerization interface [polypeptide binding]; other site 222523008223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523008224 dimer interface [polypeptide binding]; other site 222523008225 phosphorylation site [posttranslational modification] 222523008226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523008227 ATP binding site [chemical binding]; other site 222523008228 Mg2+ binding site [ion binding]; other site 222523008229 G-X-G motif; other site 222523008230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523008231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523008232 active site 222523008233 phosphorylation site [posttranslational modification] 222523008234 intermolecular recognition site; other site 222523008235 dimerization interface [polypeptide binding]; other site 222523008236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523008237 DNA binding site [nucleotide binding] 222523008238 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 222523008239 putative active site [active] 222523008240 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 222523008241 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 222523008242 TspO/MBR family; Region: TspO_MBR; pfam03073 222523008243 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 222523008244 DNA photolyase; Region: DNA_photolyase; pfam00875 222523008245 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523008246 Transcriptional regulator PadR-like family; Region: PadR; cl17335 222523008247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008248 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 222523008249 putative substrate translocation pore; other site 222523008250 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 222523008251 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 222523008252 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 222523008253 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 222523008254 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 222523008255 zinc binding site [ion binding]; other site 222523008256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 222523008257 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 222523008258 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 222523008259 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 222523008260 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 222523008261 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 222523008262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008263 putative substrate translocation pore; other site 222523008264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523008266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008267 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523008268 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 222523008269 NodB motif; other site 222523008270 active site 222523008271 catalytic site [active] 222523008272 Zn binding site [ion binding]; other site 222523008273 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523008274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008275 Coenzyme A binding pocket [chemical binding]; other site 222523008276 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 222523008277 UbiA prenyltransferase family; Region: UbiA; pfam01040 222523008278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523008279 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 222523008280 Probable transposase; Region: OrfB_IS605; pfam01385 222523008281 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523008282 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 222523008283 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 222523008284 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 222523008285 DJ-1 family protein; Region: not_thiJ; TIGR01383 222523008286 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 222523008287 conserved cys residue [active] 222523008288 Phosphotransferase enzyme family; Region: APH; pfam01636 222523008289 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 222523008290 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 222523008291 Low molecular weight phosphatase family; Region: LMWPc; cd00115 222523008292 active site 222523008293 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 222523008294 arsenical-resistance protein; Region: acr3; TIGR00832 222523008295 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523008296 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 222523008297 putative metal binding site [ion binding]; other site 222523008298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523008299 dimerization interface [polypeptide binding]; other site 222523008300 putative DNA binding site [nucleotide binding]; other site 222523008301 putative Zn2+ binding site [ion binding]; other site 222523008302 DinB superfamily; Region: DinB_2; pfam12867 222523008303 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 222523008304 RibD C-terminal domain; Region: RibD_C; cl17279 222523008305 RibD C-terminal domain; Region: RibD_C; cl17279 222523008306 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 222523008307 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 222523008308 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 222523008309 FtsX-like permease family; Region: FtsX; pfam02687 222523008310 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 222523008311 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523008312 FtsX-like permease family; Region: FtsX; pfam02687 222523008313 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523008314 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523008315 Walker A/P-loop; other site 222523008316 ATP binding site [chemical binding]; other site 222523008317 Q-loop/lid; other site 222523008318 ABC transporter signature motif; other site 222523008319 Walker B; other site 222523008320 D-loop; other site 222523008321 H-loop/switch region; other site 222523008322 Peptidase family M50; Region: Peptidase_M50; pfam02163 222523008323 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 222523008324 active site 222523008325 putative substrate binding region [chemical binding]; other site 222523008326 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 222523008327 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523008328 FeS/SAM binding site; other site 222523008329 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 222523008330 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 222523008331 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523008332 FeS/SAM binding site; other site 222523008333 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 222523008334 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 222523008335 active site 222523008336 NTP binding site [chemical binding]; other site 222523008337 metal binding triad [ion binding]; metal-binding site 222523008338 antibiotic binding site [chemical binding]; other site 222523008339 HEPN domain; Region: HEPN; cl00824 222523008340 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 222523008341 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 222523008342 putative NAD(P) binding site [chemical binding]; other site 222523008343 active site 222523008344 putative substrate binding site [chemical binding]; other site 222523008345 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523008346 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523008347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008348 AsnC family; Region: AsnC_trans_reg; pfam01037 222523008349 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523008350 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 222523008351 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 222523008352 metal binding site [ion binding]; metal-binding site 222523008353 AAA domain; Region: AAA_11; pfam13086 222523008354 Part of AAA domain; Region: AAA_19; pfam13245 222523008355 Erp protein C-terminus; Region: Erp_C; pfam06780 222523008356 AAA domain; Region: AAA_30; pfam13604 222523008357 AAA domain; Region: AAA_12; pfam13087 222523008358 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 222523008359 putative active site [active] 222523008360 catalytic site [active] 222523008361 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523008362 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 222523008363 active site 222523008364 metal binding site [ion binding]; metal-binding site 222523008365 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 222523008366 hypothetical protein; Provisional; Region: PRK06770 222523008367 Putative mono-oxygenase ydhR; Region: ydhR; cl07420 222523008368 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 222523008369 Cytochrome P450; Region: p450; pfam00067 222523008370 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 222523008371 Flavodoxin; Region: Flavodoxin_1; pfam00258 222523008372 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 222523008373 FAD binding pocket [chemical binding]; other site 222523008374 FAD binding motif [chemical binding]; other site 222523008375 catalytic residues [active] 222523008376 NAD binding pocket [chemical binding]; other site 222523008377 phosphate binding motif [ion binding]; other site 222523008378 beta-alpha-beta structure motif; other site 222523008379 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 222523008380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008381 putative substrate translocation pore; other site 222523008382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008383 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 222523008384 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 222523008385 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 222523008386 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523008387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008388 putative substrate translocation pore; other site 222523008389 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 222523008390 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 222523008391 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 222523008392 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 222523008393 putative NAD(P) binding site [chemical binding]; other site 222523008394 catalytic Zn binding site [ion binding]; other site 222523008395 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 222523008396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008397 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 222523008398 Cytochrome P450; Region: p450; cl12078 222523008399 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 222523008400 Cytochrome P450; Region: p450; cl12078 222523008401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523008402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008403 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 222523008404 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 222523008405 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 222523008406 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 222523008407 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 222523008408 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 222523008409 D-cysteine desulfhydrase; Validated; Region: PRK03910 222523008410 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 222523008411 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523008412 catalytic residue [active] 222523008413 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 222523008414 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523008415 active site 222523008416 metal binding site [ion binding]; metal-binding site 222523008417 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 222523008418 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 222523008419 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 222523008420 AAA domain; Region: AAA_33; pfam13671 222523008421 AAA domain; Region: AAA_17; pfam13207 222523008422 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 222523008423 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523008424 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523008425 Walker A/P-loop; other site 222523008426 ATP binding site [chemical binding]; other site 222523008427 Q-loop/lid; other site 222523008428 ABC transporter signature motif; other site 222523008429 Walker B; other site 222523008430 D-loop; other site 222523008431 H-loop/switch region; other site 222523008432 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 222523008433 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523008434 FtsX-like permease family; Region: FtsX; pfam02687 222523008435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523008436 dimerization interface [polypeptide binding]; other site 222523008437 putative DNA binding site [nucleotide binding]; other site 222523008438 Predicted transcriptional regulator [Transcription]; Region: COG2345 222523008439 putative Zn2+ binding site [ion binding]; other site 222523008440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008441 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523008442 putative substrate translocation pore; other site 222523008443 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 222523008444 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523008445 dimerization interface [polypeptide binding]; other site 222523008446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523008447 dimer interface [polypeptide binding]; other site 222523008448 phosphorylation site [posttranslational modification] 222523008449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523008450 ATP binding site [chemical binding]; other site 222523008451 Mg2+ binding site [ion binding]; other site 222523008452 G-X-G motif; other site 222523008453 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523008454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523008455 active site 222523008456 phosphorylation site [posttranslational modification] 222523008457 intermolecular recognition site; other site 222523008458 dimerization interface [polypeptide binding]; other site 222523008459 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523008460 DNA binding site [nucleotide binding] 222523008461 Predicted membrane protein [Function unknown]; Region: COG2364 222523008462 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523008463 Transcriptional regulators [Transcription]; Region: MarR; COG1846 222523008464 MarR family; Region: MarR; pfam01047 222523008465 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 222523008466 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008467 Coenzyme A binding pocket [chemical binding]; other site 222523008468 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 222523008469 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523008470 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523008471 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523008472 2TM domain; Region: 2TM; pfam13239 222523008473 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 222523008474 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 222523008475 putative dimer interface [polypeptide binding]; other site 222523008476 catalytic triad [active] 222523008477 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 222523008478 Uncharacterized conserved protein [Function unknown]; Region: COG4198 222523008479 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 222523008480 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 222523008481 glyoxylate reductase; Reviewed; Region: PRK13243 222523008482 putative ligand binding site [chemical binding]; other site 222523008483 putative NAD binding site [chemical binding]; other site 222523008484 putative catalytic site [active] 222523008485 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 222523008486 L-serine binding site [chemical binding]; other site 222523008487 ACT domain interface; other site 222523008488 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 222523008489 homodimer interface [polypeptide binding]; other site 222523008490 substrate-cofactor binding pocket; other site 222523008491 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523008492 catalytic residue [active] 222523008493 Uncharacterized conserved protein [Function unknown]; Region: COG2155 222523008494 CAAX protease self-immunity; Region: Abi; pfam02517 222523008495 Erythromycin esterase; Region: Erythro_esteras; pfam05139 222523008496 Putative sensor; Region: Sensor; pfam13796 222523008497 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523008498 Histidine kinase; Region: HisKA_3; pfam07730 222523008499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523008500 ATP binding site [chemical binding]; other site 222523008501 Mg2+ binding site [ion binding]; other site 222523008502 G-X-G motif; other site 222523008503 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523008504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523008505 active site 222523008506 phosphorylation site [posttranslational modification] 222523008507 intermolecular recognition site; other site 222523008508 dimerization interface [polypeptide binding]; other site 222523008509 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523008510 DNA binding residues [nucleotide binding] 222523008511 dimerization interface [polypeptide binding]; other site 222523008512 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 222523008513 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 222523008514 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 222523008515 active site 222523008516 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 222523008517 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 222523008518 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 222523008519 amidase catalytic site [active] 222523008520 Zn binding residues [ion binding]; other site 222523008521 substrate binding site [chemical binding]; other site 222523008522 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523008523 S-layer homology domain; Region: SLH; pfam00395 222523008524 S-layer homology domain; Region: SLH; pfam00395 222523008525 S-layer homology domain; Region: SLH; pfam00395 222523008526 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 222523008527 A new structural DNA glycosylase; Region: AlkD_like; cd06561 222523008528 active site 222523008529 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 222523008530 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 222523008531 putative metal binding site [ion binding]; other site 222523008532 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523008533 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 222523008534 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 222523008535 NETI protein; Region: NETI; pfam14044 222523008536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008537 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523008538 putative substrate translocation pore; other site 222523008539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523008540 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523008541 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523008542 MarR family; Region: MarR_2; pfam12802 222523008543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523008544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008545 putative substrate translocation pore; other site 222523008546 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523008547 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523008548 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 222523008549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523008550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008551 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 222523008552 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 222523008553 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 222523008554 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 222523008555 SWIM zinc finger; Region: SWIM; pfam04434 222523008556 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 222523008557 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 222523008558 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 222523008559 Walker A/P-loop; other site 222523008560 ATP binding site [chemical binding]; other site 222523008561 Q-loop/lid; other site 222523008562 ABC transporter signature motif; other site 222523008563 Walker B; other site 222523008564 D-loop; other site 222523008565 H-loop/switch region; other site 222523008566 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 222523008567 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 222523008568 Walker A/P-loop; other site 222523008569 ATP binding site [chemical binding]; other site 222523008570 Q-loop/lid; other site 222523008571 ABC transporter signature motif; other site 222523008572 Walker B; other site 222523008573 D-loop; other site 222523008574 H-loop/switch region; other site 222523008575 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 222523008576 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 222523008577 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 222523008578 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 222523008579 Predicted membrane protein [Function unknown]; Region: COG1288 222523008580 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 222523008581 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 222523008582 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523008583 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 222523008584 DDE domain; Region: DDE_Tnp_IS240; pfam13610 222523008585 Integrase core domain; Region: rve; pfam00665 222523008586 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523008587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008588 Coenzyme A binding pocket [chemical binding]; other site 222523008589 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523008590 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 222523008591 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523008592 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 222523008593 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523008594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523008595 non-specific DNA binding site [nucleotide binding]; other site 222523008596 salt bridge; other site 222523008597 sequence-specific DNA binding site [nucleotide binding]; other site 222523008598 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 222523008599 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523008600 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 222523008601 putative active site [active] 222523008602 putative NTP binding site [chemical binding]; other site 222523008603 putative nucleic acid binding site [nucleotide binding]; other site 222523008604 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 222523008605 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 222523008606 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 222523008607 putative deacylase active site [active] 222523008608 histidyl-tRNA synthetase; Provisional; Region: PRK12420 222523008609 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 222523008610 dimer interface [polypeptide binding]; other site 222523008611 motif 1; other site 222523008612 active site 222523008613 motif 2; other site 222523008614 motif 3; other site 222523008615 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 222523008616 anticodon binding site; other site 222523008617 pyruvate kinase; Validated; Region: PRK06739 222523008618 active site 222523008619 domain interfaces; other site 222523008620 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 222523008621 classical (c) SDRs; Region: SDR_c; cd05233 222523008622 NAD(P) binding site [chemical binding]; other site 222523008623 active site 222523008624 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 222523008625 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523008626 Walker A/P-loop; other site 222523008627 ATP binding site [chemical binding]; other site 222523008628 Q-loop/lid; other site 222523008629 ABC transporter signature motif; other site 222523008630 Walker B; other site 222523008631 D-loop; other site 222523008632 H-loop/switch region; other site 222523008633 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 222523008634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523008635 non-specific DNA binding site [nucleotide binding]; other site 222523008636 salt bridge; other site 222523008637 sequence-specific DNA binding site [nucleotide binding]; other site 222523008638 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 222523008639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523008640 motif II; other site 222523008641 Phosphotransferase enzyme family; Region: APH; pfam01636 222523008642 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523008643 active site 222523008644 substrate binding site [chemical binding]; other site 222523008645 ATP binding site [chemical binding]; other site 222523008646 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 222523008647 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 222523008648 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 222523008649 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 222523008650 nudix motif; other site 222523008651 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 222523008652 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523008653 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523008654 active site 222523008655 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 222523008656 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 222523008657 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 222523008658 maltose O-acetyltransferase; Provisional; Region: PRK10092 222523008659 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 222523008660 active site 222523008661 substrate binding site [chemical binding]; other site 222523008662 trimer interface [polypeptide binding]; other site 222523008663 CoA binding site [chemical binding]; other site 222523008664 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 222523008665 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 222523008666 active site 222523008667 HIGH motif; other site 222523008668 dimer interface [polypeptide binding]; other site 222523008669 KMSKS motif; other site 222523008670 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 222523008671 Domain of unknown function DUF20; Region: UPF0118; pfam01594 222523008672 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008673 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523008674 Coenzyme A binding pocket [chemical binding]; other site 222523008675 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 222523008676 homodimer interaction site [polypeptide binding]; other site 222523008677 cofactor binding site; other site 222523008678 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 222523008679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523008680 S-adenosylmethionine binding site [chemical binding]; other site 222523008681 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 222523008682 CGNR zinc finger; Region: zf-CGNR; pfam11706 222523008683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523008685 putative substrate translocation pore; other site 222523008686 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 222523008687 hypothetical protein; Provisional; Region: PRK04164 222523008688 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523008689 ATP synthase I chain; Region: ATP_synt_I; pfam03899 222523008690 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 222523008691 Domain of unknown function DUF21; Region: DUF21; pfam01595 222523008692 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 222523008693 Transporter associated domain; Region: CorC_HlyC; smart01091 222523008694 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 222523008695 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523008696 DNA binding residues [nucleotide binding] 222523008697 putative dimer interface [polypeptide binding]; other site 222523008698 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 222523008699 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 222523008700 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 222523008701 substrate binding site; other site 222523008702 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 222523008703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523008704 NAD(P) binding site [chemical binding]; other site 222523008705 active site 222523008706 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 222523008707 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523008709 S-adenosylmethionine binding site [chemical binding]; other site 222523008710 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 222523008711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523008712 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 222523008713 NAD(P) binding site [chemical binding]; other site 222523008714 active site 222523008715 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 222523008716 Variant SH3 domain; Region: SH3_2; pfam07653 222523008717 Src Homology 3 domain superfamily; Region: SH3; cl17036 222523008718 EamA-like transporter family; Region: EamA; pfam00892 222523008719 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523008720 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 222523008721 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 222523008722 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 222523008723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 222523008724 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 222523008725 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 222523008726 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 222523008727 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 222523008728 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 222523008729 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 222523008730 N- and C-terminal domain interface [polypeptide binding]; other site 222523008731 active site 222523008732 catalytic site [active] 222523008733 metal binding site [ion binding]; metal-binding site 222523008734 carbohydrate binding site [chemical binding]; other site 222523008735 ATP binding site [chemical binding]; other site 222523008736 GntP family permease; Region: GntP_permease; pfam02447 222523008737 fructuronate transporter; Provisional; Region: PRK10034; cl15264 222523008738 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 222523008739 active site 222523008740 intersubunit interactions; other site 222523008741 catalytic residue [active] 222523008742 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 222523008743 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 222523008744 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 222523008745 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 222523008746 TPP-binding site [chemical binding]; other site 222523008747 dimer interface [polypeptide binding]; other site 222523008748 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 222523008749 PYR/PP interface [polypeptide binding]; other site 222523008750 dimer interface [polypeptide binding]; other site 222523008751 TPP binding site [chemical binding]; other site 222523008752 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523008753 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 222523008754 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 222523008755 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 222523008756 hypothetical protein; Provisional; Region: PRK02487 222523008757 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 222523008758 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 222523008759 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 222523008760 IDEAL domain; Region: IDEAL; pfam08858 222523008761 Transcriptional regulator; Region: Rrf2; pfam02082 222523008762 Rrf2 family protein; Region: rrf2_super; TIGR00738 222523008763 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 222523008764 ArsC family; Region: ArsC; pfam03960 222523008765 putative catalytic residues [active] 222523008766 thiol/disulfide switch; other site 222523008767 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 222523008768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523008769 DNA-binding site [nucleotide binding]; DNA binding site 222523008770 UTRA domain; Region: UTRA; pfam07702 222523008771 putative oxidoreductase; Provisional; Region: PRK10206 222523008772 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 222523008773 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 222523008774 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 222523008775 putative hydrophobic ligand binding site [chemical binding]; other site 222523008776 protein interface [polypeptide binding]; other site 222523008777 gate; other site 222523008778 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 222523008779 catalytic triad [active] 222523008780 oxyanion hole [active] 222523008781 active site 222523008782 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523008783 Phosphotransferase enzyme family; Region: APH; pfam01636 222523008784 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 222523008785 substrate binding site [chemical binding]; other site 222523008786 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 222523008787 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 222523008788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008789 Coenzyme A binding pocket [chemical binding]; other site 222523008790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523008791 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523008792 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523008793 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523008794 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523008795 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 222523008796 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 222523008797 acyl-activating enzyme (AAE) consensus motif; other site 222523008798 AMP binding site [chemical binding]; other site 222523008799 active site 222523008800 CoA binding site [chemical binding]; other site 222523008801 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 222523008802 Predicted transcriptional regulators [Transcription]; Region: COG1733 222523008803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523008804 dimerization interface [polypeptide binding]; other site 222523008805 putative DNA binding site [nucleotide binding]; other site 222523008806 putative Zn2+ binding site [ion binding]; other site 222523008807 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523008808 dimerization interface [polypeptide binding]; other site 222523008809 putative DNA binding site [nucleotide binding]; other site 222523008810 putative Zn2+ binding site [ion binding]; other site 222523008811 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 222523008812 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 222523008813 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523008814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523008815 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 222523008816 active site 222523008817 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 222523008818 Predicted transcriptional regulator [Transcription]; Region: COG2378 222523008819 HTH domain; Region: HTH_11; pfam08279 222523008820 WYL domain; Region: WYL; pfam13280 222523008821 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 222523008822 nudix motif; other site 222523008823 ABC-2 type transporter; Region: ABC2_membrane; cl17235 222523008824 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 222523008825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523008826 Walker A/P-loop; other site 222523008827 ATP binding site [chemical binding]; other site 222523008828 Q-loop/lid; other site 222523008829 ABC transporter signature motif; other site 222523008830 Walker B; other site 222523008831 D-loop; other site 222523008832 H-loop/switch region; other site 222523008833 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 222523008834 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523008835 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523008836 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 222523008837 ACS interaction site; other site 222523008838 CODH interaction site; other site 222523008839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523008840 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 222523008841 metal binding site [ion binding]; metal-binding site 222523008842 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 222523008843 hypothetical protein; Provisional; Region: PRK06771 222523008844 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523008845 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523008846 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 222523008847 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 222523008848 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523008849 active site 222523008850 metal binding site [ion binding]; metal-binding site 222523008851 homotetramer interface [polypeptide binding]; other site 222523008852 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 222523008853 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 222523008854 ligand binding site [chemical binding]; other site 222523008855 flexible hinge region; other site 222523008856 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 222523008857 Protein of unknown function, DUF606; Region: DUF606; pfam04657 222523008858 Protein of unknown function, DUF606; Region: DUF606; pfam04657 222523008859 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523008860 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 222523008861 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 222523008862 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 222523008863 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523008864 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523008865 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 222523008866 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 222523008867 putative NAD(P) binding site [chemical binding]; other site 222523008868 dimer interface [polypeptide binding]; other site 222523008869 putative transport protein YifK; Provisional; Region: PRK10746 222523008870 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 222523008871 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523008872 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 222523008873 Probable transposase; Region: OrfB_IS605; pfam01385 222523008874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008875 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 222523008876 active site 222523008877 catalytic motif [active] 222523008878 Zn binding site [ion binding]; other site 222523008879 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 222523008880 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 222523008881 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 222523008882 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 222523008883 transmembrane helices; other site 222523008884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523008885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008886 Coenzyme A binding pocket [chemical binding]; other site 222523008887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523008888 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 222523008889 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 222523008890 putative ligand binding residues [chemical binding]; other site 222523008891 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 222523008892 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523008893 ABC-ATPase subunit interface; other site 222523008894 dimer interface [polypeptide binding]; other site 222523008895 putative PBP binding regions; other site 222523008896 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523008897 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523008898 ABC-ATPase subunit interface; other site 222523008899 dimer interface [polypeptide binding]; other site 222523008900 putative PBP binding regions; other site 222523008901 Protein of unknown function (DUF817); Region: DUF817; pfam05675 222523008902 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 222523008903 DinB superfamily; Region: DinB_2; pfam12867 222523008904 DinB family; Region: DinB; cl17821 222523008905 DinB superfamily; Region: DinB_2; pfam12867 222523008906 CAAX protease self-immunity; Region: Abi; pfam02517 222523008907 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 222523008908 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 222523008909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523008910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523008911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523008912 dimerization interface [polypeptide binding]; other site 222523008913 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523008914 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 222523008915 NADP binding site [chemical binding]; other site 222523008916 dimer interface [polypeptide binding]; other site 222523008917 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523008918 catalytic core [active] 222523008919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008920 Coenzyme A binding pocket [chemical binding]; other site 222523008921 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 222523008922 MutS domain III; Region: MutS_III; pfam05192 222523008923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523008924 Walker A/P-loop; other site 222523008925 ATP binding site [chemical binding]; other site 222523008926 Q-loop/lid; other site 222523008927 ABC transporter signature motif; other site 222523008928 Walker B; other site 222523008929 D-loop; other site 222523008930 H-loop/switch region; other site 222523008931 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 222523008932 oligoendopeptidase F; Region: pepF; TIGR00181 222523008933 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 222523008934 active site 222523008935 Zn binding site [ion binding]; other site 222523008936 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 222523008937 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523008938 DNA binding residues [nucleotide binding] 222523008939 drug binding residues [chemical binding]; other site 222523008940 dimer interface [polypeptide binding]; other site 222523008941 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 222523008942 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 222523008943 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 222523008944 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 222523008945 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523008946 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523008947 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523008948 putative substrate translocation pore; other site 222523008949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523008950 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523008951 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523008952 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 222523008953 putative dimerization interface [polypeptide binding]; other site 222523008954 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 222523008955 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 222523008956 putative active site [active] 222523008957 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 222523008958 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 222523008959 active site 222523008960 catalytic site [active] 222523008961 metal binding site [ion binding]; metal-binding site 222523008962 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 222523008963 Part of AAA domain; Region: AAA_19; pfam13245 222523008964 Family description; Region: UvrD_C_2; pfam13538 222523008965 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523008966 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523008967 FAD binding domain; Region: FAD_binding_3; pfam01494 222523008968 hypothetical protein; Provisional; Region: PRK07236 222523008969 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523008970 dimerization interface [polypeptide binding]; other site 222523008971 putative DNA binding site [nucleotide binding]; other site 222523008972 putative Zn2+ binding site [ion binding]; other site 222523008973 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 222523008974 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 222523008975 putative NAD(P) binding site [chemical binding]; other site 222523008976 Uncharacterized conserved protein [Function unknown]; Region: COG0397 222523008977 hypothetical protein; Validated; Region: PRK00029 222523008978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 222523008979 TPR motif; other site 222523008980 binding surface 222523008981 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523008982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523008983 TPR motif; other site 222523008984 binding surface 222523008985 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 222523008986 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 222523008987 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 222523008988 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 222523008989 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 222523008990 Sodium Bile acid symporter family; Region: SBF; cl17470 222523008991 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 222523008992 FAD binding domain; Region: FAD_binding_4; pfam01565 222523008993 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523008994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523008995 Coenzyme A binding pocket [chemical binding]; other site 222523008996 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523008997 MarR family; Region: MarR_2; pfam12802 222523008998 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 222523008999 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 222523009000 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 222523009001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523009002 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523009003 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 222523009004 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 222523009005 FOG: PKD repeat [General function prediction only]; Region: COG3291 222523009006 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 222523009007 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 222523009008 MgtC family; Region: MgtC; pfam02308 222523009009 Predicted acetyltransferase [General function prediction only]; Region: COG3981 222523009010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523009011 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 222523009012 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 222523009013 putative metal binding site [ion binding]; other site 222523009014 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 222523009015 active site 222523009016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523009017 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 222523009018 substrate binding pocket [chemical binding]; other site 222523009019 membrane-bound complex binding site; other site 222523009020 hinge residues; other site 222523009021 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523009022 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523009023 Walker A/P-loop; other site 222523009024 ATP binding site [chemical binding]; other site 222523009025 Q-loop/lid; other site 222523009026 ABC transporter signature motif; other site 222523009027 Walker B; other site 222523009028 D-loop; other site 222523009029 H-loop/switch region; other site 222523009030 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 222523009031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523009032 dimer interface [polypeptide binding]; other site 222523009033 conserved gate region; other site 222523009034 putative PBP binding loops; other site 222523009035 ABC-ATPase subunit interface; other site 222523009036 VanW like protein; Region: VanW; pfam04294 222523009037 Sensor protein DegS; Region: DegS; pfam05384 222523009038 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 222523009039 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 222523009040 exonuclease; Provisional; Region: PRK06722 222523009041 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 222523009042 active site 222523009043 catalytic site [active] 222523009044 substrate binding site [chemical binding]; other site 222523009045 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 222523009046 DNA-binding site [nucleotide binding]; DNA binding site 222523009047 RNA-binding motif; other site 222523009048 flavodoxin; Provisional; Region: PRK06703 222523009049 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 222523009050 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 222523009051 nudix motif; other site 222523009052 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 222523009053 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 222523009054 trimer interface [polypeptide binding]; other site 222523009055 active site 222523009056 substrate binding site [chemical binding]; other site 222523009057 CoA binding site [chemical binding]; other site 222523009058 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009059 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009060 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009061 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009062 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009063 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009064 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009065 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009066 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009067 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009068 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009069 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009070 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009071 short chain dehydrogenase; Provisional; Region: PRK06924 222523009072 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 222523009073 NADP binding site [chemical binding]; other site 222523009074 homodimer interface [polypeptide binding]; other site 222523009075 active site 222523009076 Predicted acetyltransferase [General function prediction only]; Region: COG3393 222523009077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523009078 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 222523009079 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 222523009080 active sites [active] 222523009081 tetramer interface [polypeptide binding]; other site 222523009082 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523009083 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523009084 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 222523009085 active site 222523009086 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 222523009087 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 222523009088 Na binding site [ion binding]; other site 222523009089 Protein of unknown function (DUF997); Region: DUF997; pfam06196 222523009090 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 222523009091 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 222523009092 NAD(P) binding site [chemical binding]; other site 222523009093 catalytic residues [active] 222523009094 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 222523009095 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 222523009096 NAD(P) binding site [chemical binding]; other site 222523009097 homotetramer interface [polypeptide binding]; other site 222523009098 homodimer interface [polypeptide binding]; other site 222523009099 active site 222523009100 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 222523009101 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 222523009102 Divergent PAP2 family; Region: DUF212; pfam02681 222523009103 Predicted permeases [General function prediction only]; Region: RarD; COG2962 222523009104 EamA-like transporter family; Region: EamA; pfam00892 222523009105 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 222523009106 antiporter inner membrane protein; Provisional; Region: PRK11670 222523009107 Domain of unknown function DUF59; Region: DUF59; pfam01883 222523009108 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 222523009109 Walker A motif; other site 222523009110 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 222523009111 MoaE interaction surface [polypeptide binding]; other site 222523009112 MoeB interaction surface [polypeptide binding]; other site 222523009113 thiocarboxylated glycine; other site 222523009114 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 222523009115 MoaE homodimer interface [polypeptide binding]; other site 222523009116 MoaD interaction [polypeptide binding]; other site 222523009117 active site residues [active] 222523009118 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 222523009119 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 222523009120 dimer interface [polypeptide binding]; other site 222523009121 putative functional site; other site 222523009122 putative MPT binding site; other site 222523009123 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 222523009124 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 222523009125 ATP binding site [chemical binding]; other site 222523009126 substrate interface [chemical binding]; other site 222523009127 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 222523009128 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 222523009129 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523009130 FeS/SAM binding site; other site 222523009131 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 222523009132 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 222523009133 Uncharacterized conserved protein [Function unknown]; Region: COG5609 222523009134 Uncharacterized conserved protein [Function unknown]; Region: COG2427 222523009135 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 222523009136 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 222523009137 catalytic loop [active] 222523009138 iron binding site [ion binding]; other site 222523009139 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 222523009140 4Fe-4S binding domain; Region: Fer4; pfam00037 222523009141 4Fe-4S binding domain; Region: Fer4; pfam00037 222523009142 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 222523009143 [4Fe-4S] binding site [ion binding]; other site 222523009144 molybdopterin cofactor binding site; other site 222523009145 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 222523009146 molybdopterin cofactor binding site; other site 222523009147 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523009148 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523009149 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 222523009150 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 222523009151 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 222523009152 Tubulin like; Region: Tubulin_2; pfam13809 222523009153 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 222523009154 metal ion-dependent adhesion site (MIDAS); other site 222523009155 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523009156 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 222523009157 active site 222523009158 metal binding site [ion binding]; metal-binding site 222523009159 Methyltransferase domain; Region: Methyltransf_31; pfam13847 222523009160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523009161 S-adenosylmethionine binding site [chemical binding]; other site 222523009162 O-methyltransferase; Region: Methyltransf_2; pfam00891 222523009163 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523009164 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523009165 peptide binding site [polypeptide binding]; other site 222523009166 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523009167 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523009168 peptide binding site [polypeptide binding]; other site 222523009169 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 222523009170 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 222523009171 peptide binding site [polypeptide binding]; other site 222523009172 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 222523009173 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 222523009174 Transcriptional regulator [Transcription]; Region: LytR; COG1316 222523009175 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 222523009176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523009177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523009178 DNA binding residues [nucleotide binding] 222523009179 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 222523009180 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523009181 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523009182 Walker A/P-loop; other site 222523009183 ATP binding site [chemical binding]; other site 222523009184 Q-loop/lid; other site 222523009185 ABC transporter signature motif; other site 222523009186 Walker B; other site 222523009187 D-loop; other site 222523009188 H-loop/switch region; other site 222523009189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523009190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523009191 HTH domain; Region: HTH_11; pfam08279 222523009192 WYL domain; Region: WYL; pfam13280 222523009193 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 222523009194 dimer interface [polypeptide binding]; other site 222523009195 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523009196 putative oxidoreductase; Provisional; Region: PRK11579 222523009197 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 222523009198 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 222523009199 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 222523009200 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 222523009201 CAP-like domain; other site 222523009202 active site 222523009203 primary dimer interface [polypeptide binding]; other site 222523009204 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523009205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523009206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523009207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 222523009208 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 222523009209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523009210 ATP binding site [chemical binding]; other site 222523009211 Mg2+ binding site [ion binding]; other site 222523009212 G-X-G motif; other site 222523009213 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 222523009214 anchoring element; other site 222523009215 dimer interface [polypeptide binding]; other site 222523009216 ATP binding site [chemical binding]; other site 222523009217 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 222523009218 active site 222523009219 putative metal-binding site [ion binding]; other site 222523009220 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 222523009221 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 222523009222 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 222523009223 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 222523009224 protein binding site [polypeptide binding]; other site 222523009225 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523009226 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523009227 active site 222523009228 phosphorylation site [posttranslational modification] 222523009229 intermolecular recognition site; other site 222523009230 dimerization interface [polypeptide binding]; other site 222523009231 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523009232 DNA binding site [nucleotide binding] 222523009233 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 222523009234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523009235 FeS/SAM binding site; other site 222523009236 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 222523009237 Class III ribonucleotide reductase; Region: RNR_III; cd01675 222523009238 effector binding site; other site 222523009239 active site 222523009240 Zn binding site [ion binding]; other site 222523009241 glycine loop; other site 222523009242 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 222523009243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 222523009244 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 222523009245 active site 222523009246 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 222523009247 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523009248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523009249 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 222523009250 active site 222523009251 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 222523009252 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 222523009253 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 222523009254 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 222523009255 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 222523009256 active site 222523009257 catalytic site [active] 222523009258 substrate binding site [chemical binding]; other site 222523009259 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 222523009260 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 222523009261 catalytic residues [active] 222523009262 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523009263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523009264 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 222523009265 Walker A/P-loop; other site 222523009266 ATP binding site [chemical binding]; other site 222523009267 ABC transporter signature motif; other site 222523009268 Walker B; other site 222523009269 D-loop; other site 222523009270 H-loop/switch region; other site 222523009271 aconitate hydratase; Validated; Region: PRK09277 222523009272 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 222523009273 substrate binding site [chemical binding]; other site 222523009274 ligand binding site [chemical binding]; other site 222523009275 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 222523009276 substrate binding site [chemical binding]; other site 222523009277 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 222523009278 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523009279 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 222523009280 NodB motif; other site 222523009281 active site 222523009282 catalytic site [active] 222523009283 metal binding site [ion binding]; metal-binding site 222523009284 Small acid-soluble spore protein P family; Region: SspP; cl12105 222523009285 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 222523009286 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 222523009287 putative dimer interface [polypeptide binding]; other site 222523009288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523009289 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523009290 putative substrate translocation pore; other site 222523009291 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 222523009292 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 222523009293 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 222523009294 nudix motif; other site 222523009295 SAP domain; Region: SAP; pfam02037 222523009296 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 222523009297 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 222523009298 dimer interface [polypeptide binding]; other site 222523009299 active site 222523009300 acyl-CoA synthetase; Validated; Region: PRK07638 222523009301 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 222523009302 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 222523009303 acyl-activating enzyme (AAE) consensus motif; other site 222523009304 acyl-activating enzyme (AAE) consensus motif; other site 222523009305 AMP binding site [chemical binding]; other site 222523009306 active site 222523009307 CoA binding site [chemical binding]; other site 222523009308 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 222523009309 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 222523009310 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 222523009311 dimer interface [polypeptide binding]; other site 222523009312 acyl-activating enzyme (AAE) consensus motif; other site 222523009313 putative active site [active] 222523009314 AMP binding site [chemical binding]; other site 222523009315 putative CoA binding site [chemical binding]; other site 222523009316 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 222523009317 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523009318 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523009319 Walker A/P-loop; other site 222523009320 ATP binding site [chemical binding]; other site 222523009321 Q-loop/lid; other site 222523009322 ABC transporter signature motif; other site 222523009323 Walker B; other site 222523009324 D-loop; other site 222523009325 H-loop/switch region; other site 222523009326 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523009327 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523009328 non-specific DNA binding site [nucleotide binding]; other site 222523009329 salt bridge; other site 222523009330 sequence-specific DNA binding site [nucleotide binding]; other site 222523009331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523009332 Coenzyme A binding pocket [chemical binding]; other site 222523009333 High-affinity nickel-transport protein; Region: NicO; cl00964 222523009334 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 222523009335 UreD urease accessory protein; Region: UreD; pfam01774 222523009336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 222523009337 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 222523009338 UreF; Region: UreF; pfam01730 222523009339 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 222523009340 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 222523009341 dimer interface [polypeptide binding]; other site 222523009342 catalytic residues [active] 222523009343 urease subunit alpha; Reviewed; Region: ureC; PRK13207 222523009344 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 222523009345 subunit interactions [polypeptide binding]; other site 222523009346 active site 222523009347 flap region; other site 222523009348 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 222523009349 gamma-beta subunit interface [polypeptide binding]; other site 222523009350 alpha-beta subunit interface [polypeptide binding]; other site 222523009351 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 222523009352 alpha-gamma subunit interface [polypeptide binding]; other site 222523009353 beta-gamma subunit interface [polypeptide binding]; other site 222523009354 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 222523009355 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 222523009356 amidase catalytic site [active] 222523009357 Zn binding residues [ion binding]; other site 222523009358 substrate binding site [chemical binding]; other site 222523009359 active site 222523009360 Protein phosphatase 2C; Region: PP2C_2; pfam13672 222523009361 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523009362 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523009363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523009364 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 222523009365 dimer interface [polypeptide binding]; other site 222523009366 putative metal binding site [ion binding]; other site 222523009367 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523009368 PAS domain; Region: PAS_9; pfam13426 222523009369 putative active site [active] 222523009370 heme pocket [chemical binding]; other site 222523009371 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 222523009372 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523009373 putative active site [active] 222523009374 heme pocket [chemical binding]; other site 222523009375 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523009376 dimer interface [polypeptide binding]; other site 222523009377 phosphorylation site [posttranslational modification] 222523009378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523009379 ATP binding site [chemical binding]; other site 222523009380 Mg2+ binding site [ion binding]; other site 222523009381 G-X-G motif; other site 222523009382 Predicted esterase [General function prediction only]; Region: COG0400 222523009383 putative hydrolase; Provisional; Region: PRK11460 222523009384 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 222523009385 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523009386 Zn binding site [ion binding]; other site 222523009387 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 222523009388 Zn binding site [ion binding]; other site 222523009389 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 222523009390 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 222523009391 Na binding site [ion binding]; other site 222523009392 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 222523009393 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 222523009394 active site 222523009395 FMN binding site [chemical binding]; other site 222523009396 substrate binding site [chemical binding]; other site 222523009397 3Fe-4S cluster binding site [ion binding]; other site 222523009398 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 222523009399 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 222523009400 FMN binding site [chemical binding]; other site 222523009401 active site 222523009402 substrate binding site [chemical binding]; other site 222523009403 catalytic residue [active] 222523009404 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 222523009405 agmatinase; Region: agmatinase; TIGR01230 222523009406 Agmatinase-like family; Region: Agmatinase-like; cd09990 222523009407 active site 222523009408 oligomer interface [polypeptide binding]; other site 222523009409 Mn binding site [ion binding]; other site 222523009410 imidazolonepropionase; Validated; Region: PRK09356 222523009411 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 222523009412 active site 222523009413 urocanate hydratase; Provisional; Region: PRK05414 222523009414 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 222523009415 active sites [active] 222523009416 tetramer interface [polypeptide binding]; other site 222523009417 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 222523009418 hexamer interface [polypeptide binding]; other site 222523009419 RNA binding site [nucleotide binding]; other site 222523009420 Histidine-zinc binding site [chemical binding]; other site 222523009421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523009422 S-adenosylmethionine binding site [chemical binding]; other site 222523009423 DJ-1 family protein; Region: not_thiJ; TIGR01383 222523009424 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 222523009425 conserved cys residue [active] 222523009426 AAA domain; Region: AAA_28; pfam13521 222523009427 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 222523009428 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009429 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009430 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009431 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009432 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009433 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009434 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009435 Domain of unknown function DUF11; Region: DUF11; cl17728 222523009436 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009437 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009438 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009439 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009440 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009441 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009442 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009443 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009444 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523009445 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 222523009446 putative active site [active] 222523009447 putative NTP binding site [chemical binding]; other site 222523009448 putative nucleic acid binding site [nucleotide binding]; other site 222523009449 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 222523009450 active site 222523009451 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009452 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009453 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523009454 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 222523009455 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 222523009456 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 222523009457 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523009458 EamA-like transporter family; Region: EamA; pfam00892 222523009459 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 222523009460 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 222523009461 metal binding site [ion binding]; metal-binding site 222523009462 dimer interface [polypeptide binding]; other site 222523009463 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 222523009464 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 222523009465 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523009466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523009467 Walker A/P-loop; other site 222523009468 ATP binding site [chemical binding]; other site 222523009469 Q-loop/lid; other site 222523009470 ABC transporter signature motif; other site 222523009471 Walker B; other site 222523009472 D-loop; other site 222523009473 H-loop/switch region; other site 222523009474 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 222523009475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523009476 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 222523009477 putative dimerization interface [polypeptide binding]; other site 222523009478 putative substrate binding pocket [chemical binding]; other site 222523009479 holin-like protein; Validated; Region: PRK01658 222523009480 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 222523009481 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 222523009482 nudix motif; other site 222523009483 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 222523009484 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 222523009485 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 222523009486 amidase catalytic site [active] 222523009487 Zn binding residues [ion binding]; other site 222523009488 substrate binding site [chemical binding]; other site 222523009489 S-layer homology domain; Region: SLH; pfam00395 222523009490 S-layer homology domain; Region: SLH; pfam00395 222523009491 S-layer homology domain; Region: SLH; pfam00395 222523009492 Nuclease-related domain; Region: NERD; pfam08378 222523009493 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 222523009494 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 222523009495 active site 222523009496 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523009497 Bacterial SH3 domain homologues; Region: SH3b; smart00287 222523009498 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523009499 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523009500 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 222523009501 Walker A/P-loop; other site 222523009502 ATP binding site [chemical binding]; other site 222523009503 Q-loop/lid; other site 222523009504 ABC transporter signature motif; other site 222523009505 Walker B; other site 222523009506 D-loop; other site 222523009507 H-loop/switch region; other site 222523009508 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523009509 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 222523009510 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523009511 Walker A/P-loop; other site 222523009512 ATP binding site [chemical binding]; other site 222523009513 Q-loop/lid; other site 222523009514 ABC transporter signature motif; other site 222523009515 Walker B; other site 222523009516 D-loop; other site 222523009517 H-loop/switch region; other site 222523009518 hypothetical protein; Provisional; Region: PRK01844 222523009519 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 222523009520 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 222523009521 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 222523009522 TPP-binding site [chemical binding]; other site 222523009523 dimer interface [polypeptide binding]; other site 222523009524 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 222523009525 PYR/PP interface [polypeptide binding]; other site 222523009526 dimer interface [polypeptide binding]; other site 222523009527 TPP binding site [chemical binding]; other site 222523009528 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523009529 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 222523009530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523009531 dimer interface [polypeptide binding]; other site 222523009532 conserved gate region; other site 222523009533 ABC-ATPase subunit interface; other site 222523009534 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 222523009535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523009536 dimer interface [polypeptide binding]; other site 222523009537 conserved gate region; other site 222523009538 ABC-ATPase subunit interface; other site 222523009539 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 222523009540 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 222523009541 Walker A/P-loop; other site 222523009542 ATP binding site [chemical binding]; other site 222523009543 Q-loop/lid; other site 222523009544 ABC transporter signature motif; other site 222523009545 Walker B; other site 222523009546 D-loop; other site 222523009547 H-loop/switch region; other site 222523009548 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 222523009549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523009550 membrane-bound complex binding site; other site 222523009551 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 222523009552 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 222523009553 active site 222523009554 metal binding site [ion binding]; metal-binding site 222523009555 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 222523009556 hypothetical protein; Provisional; Region: PRK01546 222523009557 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523009558 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523009559 catalytic residues [active] 222523009560 catalytic nucleophile [active] 222523009561 LexA repressor; Validated; Region: PRK00215 222523009562 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523009563 putative DNA binding site [nucleotide binding]; other site 222523009564 putative Zn2+ binding site [ion binding]; other site 222523009565 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 222523009566 Catalytic site [active] 222523009567 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 222523009568 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 222523009569 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 222523009570 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523009571 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523009572 glutamine synthetase, type I; Region: GlnA; TIGR00653 222523009573 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 222523009574 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 222523009575 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 222523009576 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523009577 DNA binding residues [nucleotide binding] 222523009578 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 222523009579 Aluminium resistance protein; Region: Alum_res; pfam06838 222523009580 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 222523009581 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 222523009582 HflX GTPase family; Region: HflX; cd01878 222523009583 G1 box; other site 222523009584 GTP/Mg2+ binding site [chemical binding]; other site 222523009585 Switch I region; other site 222523009586 G2 box; other site 222523009587 G3 box; other site 222523009588 Switch II region; other site 222523009589 G4 box; other site 222523009590 G5 box; other site 222523009591 Predicted membrane protein [Function unknown]; Region: COG2860 222523009592 UPF0126 domain; Region: UPF0126; pfam03458 222523009593 UPF0126 domain; Region: UPF0126; pfam03458 222523009594 stage V sporulation protein K; Region: spore_V_K; TIGR02881 222523009595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523009596 Walker A motif; other site 222523009597 ATP binding site [chemical binding]; other site 222523009598 Walker B motif; other site 222523009599 arginine finger; other site 222523009600 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 222523009601 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 222523009602 active site 222523009603 catalytic residues [active] 222523009604 DNA binding site [nucleotide binding] 222523009605 Int/Topo IB signature motif; other site 222523009606 bacterial Hfq-like; Region: Hfq; cd01716 222523009607 hexamer interface [polypeptide binding]; other site 222523009608 Sm1 motif; other site 222523009609 RNA binding site [nucleotide binding]; other site 222523009610 Sm2 motif; other site 222523009611 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 222523009612 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 222523009613 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523009614 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523009615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 222523009616 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 222523009617 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 222523009618 active site 222523009619 phosphorylation site [posttranslational modification] 222523009620 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 222523009621 active site 222523009622 P-loop; other site 222523009623 phosphorylation site [posttranslational modification] 222523009624 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 222523009625 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 222523009626 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 222523009627 putative substrate binding site [chemical binding]; other site 222523009628 putative ATP binding site [chemical binding]; other site 222523009629 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 222523009630 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 222523009631 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 222523009632 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 222523009633 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 222523009634 dimer interface [polypeptide binding]; other site 222523009635 active site 222523009636 metal binding site [ion binding]; metal-binding site 222523009637 Predicted membrane protein [Function unknown]; Region: COG2322 222523009638 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 222523009639 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 222523009640 Glyco_18 domain; Region: Glyco_18; smart00636 222523009641 putative active site [active] 222523009642 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 222523009643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523009644 putative active site [active] 222523009645 putative metal binding site [ion binding]; other site 222523009646 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 222523009647 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 222523009648 IHF dimer interface [polypeptide binding]; other site 222523009649 IHF - DNA interface [nucleotide binding]; other site 222523009650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523009651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523009652 Coenzyme A binding pocket [chemical binding]; other site 222523009653 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523009654 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523009655 metal-binding site [ion binding] 222523009656 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523009657 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523009658 metal-binding site [ion binding] 222523009659 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523009660 Soluble P-type ATPase [General function prediction only]; Region: COG4087 222523009661 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523009662 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523009663 metal-binding site [ion binding] 222523009664 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 222523009665 putative homodimer interface [polypeptide binding]; other site 222523009666 putative homotetramer interface [polypeptide binding]; other site 222523009667 putative allosteric switch controlling residues; other site 222523009668 putative metal binding site [ion binding]; other site 222523009669 putative homodimer-homodimer interface [polypeptide binding]; other site 222523009670 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 222523009671 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 222523009672 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 222523009673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523009674 catalytic core [active] 222523009675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523009676 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523009677 dimerization interface [polypeptide binding]; other site 222523009678 putative DNA binding site [nucleotide binding]; other site 222523009679 putative Zn2+ binding site [ion binding]; other site 222523009680 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 222523009681 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 222523009682 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 222523009683 Walker A/P-loop; other site 222523009684 ATP binding site [chemical binding]; other site 222523009685 Q-loop/lid; other site 222523009686 ABC transporter signature motif; other site 222523009687 Walker B; other site 222523009688 D-loop; other site 222523009689 H-loop/switch region; other site 222523009690 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 222523009691 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523009692 ABC-ATPase subunit interface; other site 222523009693 dimer interface [polypeptide binding]; other site 222523009694 putative PBP binding regions; other site 222523009695 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523009696 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523009697 ABC-ATPase subunit interface; other site 222523009698 dimer interface [polypeptide binding]; other site 222523009699 putative PBP binding regions; other site 222523009700 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 222523009701 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 222523009702 putative ligand binding residues [chemical binding]; other site 222523009703 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 222523009704 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 222523009705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523009706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523009707 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 222523009708 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 222523009709 DNA binding site [nucleotide binding] 222523009710 active site 222523009711 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 222523009712 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 222523009713 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 222523009714 minor groove reading motif; other site 222523009715 helix-hairpin-helix signature motif; other site 222523009716 substrate binding pocket [chemical binding]; other site 222523009717 active site 222523009718 peptidase T; Region: peptidase-T; TIGR01882 222523009719 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 222523009720 metal binding site [ion binding]; metal-binding site 222523009721 dimer interface [polypeptide binding]; other site 222523009722 Predicted membrane protein [Function unknown]; Region: COG2364 222523009723 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523009724 hypothetical protein; Provisional; Region: PRK06764 222523009725 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523009726 catalytic core [active] 222523009727 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523009728 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523009729 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 222523009730 active site 222523009731 PAS domain S-box; Region: sensory_box; TIGR00229 222523009732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523009733 putative active site [active] 222523009734 heme pocket [chemical binding]; other site 222523009735 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 222523009736 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523009737 metal binding site [ion binding]; metal-binding site 222523009738 active site 222523009739 I-site; other site 222523009740 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 222523009741 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 222523009742 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523009743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523009744 active site 222523009745 motif I; other site 222523009746 motif II; other site 222523009747 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 222523009748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 222523009749 ligand binding site [chemical binding]; other site 222523009750 flexible hinge region; other site 222523009751 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 222523009752 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 222523009753 LrgB-like family; Region: LrgB; cl00596 222523009754 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 222523009755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523009756 DNA-binding site [nucleotide binding]; DNA binding site 222523009757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523009758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523009759 homodimer interface [polypeptide binding]; other site 222523009760 catalytic residue [active] 222523009761 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 222523009762 active site 222523009763 catalytic site [active] 222523009764 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 222523009765 putative active site [active] 222523009766 putative catalytic triad [active] 222523009767 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 222523009768 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523009769 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 222523009770 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523009771 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 222523009772 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 222523009773 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 222523009774 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 222523009775 Sulfatase; Region: Sulfatase; pfam00884 222523009776 Tetratricopeptide repeat; Region: TPR_16; pfam13432 222523009777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523009778 binding surface 222523009779 TPR motif; other site 222523009780 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 222523009781 G1 box; other site 222523009782 GTP/Mg2+ binding site [chemical binding]; other site 222523009783 Switch I region; other site 222523009784 G3 box; other site 222523009785 Switch II region; other site 222523009786 G4 box; other site 222523009787 G5 box; other site 222523009788 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 222523009789 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 222523009790 active site 222523009791 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 222523009792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523009793 ATP binding site [chemical binding]; other site 222523009794 Mg2+ binding site [ion binding]; other site 222523009795 G-X-G motif; other site 222523009796 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 222523009797 ATP binding site [chemical binding]; other site 222523009798 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 222523009799 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 222523009800 MutS domain I; Region: MutS_I; pfam01624 222523009801 MutS domain II; Region: MutS_II; pfam05188 222523009802 MutS domain III; Region: MutS_III; pfam05192 222523009803 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 222523009804 Walker A/P-loop; other site 222523009805 ATP binding site [chemical binding]; other site 222523009806 Q-loop/lid; other site 222523009807 ABC transporter signature motif; other site 222523009808 Walker B; other site 222523009809 D-loop; other site 222523009810 H-loop/switch region; other site 222523009811 Outer spore coat protein E (CotE); Region: CotE; pfam10628 222523009812 Predicted membrane protein [Function unknown]; Region: COG4550 222523009813 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 222523009814 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 222523009815 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523009816 FeS/SAM binding site; other site 222523009817 TRAM domain; Region: TRAM; pfam01938 222523009818 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 222523009819 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 222523009820 TPP-binding site [chemical binding]; other site 222523009821 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 222523009822 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 222523009823 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 222523009824 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 222523009825 dimer interface [polypeptide binding]; other site 222523009826 PYR/PP interface [polypeptide binding]; other site 222523009827 TPP binding site [chemical binding]; other site 222523009828 substrate binding site [chemical binding]; other site 222523009829 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523009830 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 222523009831 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 222523009832 active site 222523009833 dimer interface [polypeptide binding]; other site 222523009834 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 222523009835 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 222523009836 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 222523009837 putative active site [active] 222523009838 metal binding site [ion binding]; metal-binding site 222523009839 homodimer binding site [polypeptide binding]; other site 222523009840 phosphodiesterase; Provisional; Region: PRK12704 222523009841 Uncharacterized conserved protein [Function unknown]; Region: COG3334 222523009842 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523009843 Zn2+ binding site [ion binding]; other site 222523009844 Mg2+ binding site [ion binding]; other site 222523009845 recombinase A; Provisional; Region: recA; PRK09354 222523009846 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 222523009847 hexamer interface [polypeptide binding]; other site 222523009848 Walker A motif; other site 222523009849 ATP binding site [chemical binding]; other site 222523009850 Walker B motif; other site 222523009851 competence damage-inducible protein A; Provisional; Region: PRK00549 222523009852 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 222523009853 putative MPT binding site; other site 222523009854 Competence-damaged protein; Region: CinA; pfam02464 222523009855 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 222523009856 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 222523009857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523009858 non-specific DNA binding site [nucleotide binding]; other site 222523009859 salt bridge; other site 222523009860 sequence-specific DNA binding site [nucleotide binding]; other site 222523009861 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 222523009862 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 222523009863 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 222523009864 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 222523009865 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 222523009866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523009867 NAD(P) binding site [chemical binding]; other site 222523009868 active site 222523009869 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 222523009870 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 222523009871 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 222523009872 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 222523009873 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 222523009874 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 222523009875 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 222523009876 TM-ABC transporter signature motif; other site 222523009877 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 222523009878 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 222523009879 TM-ABC transporter signature motif; other site 222523009880 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 222523009881 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 222523009882 Walker A/P-loop; other site 222523009883 ATP binding site [chemical binding]; other site 222523009884 Q-loop/lid; other site 222523009885 ABC transporter signature motif; other site 222523009886 Walker B; other site 222523009887 D-loop; other site 222523009888 H-loop/switch region; other site 222523009889 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 222523009890 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 222523009891 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 222523009892 ligand binding site [chemical binding]; other site 222523009893 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 222523009894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523009895 DNA-binding site [nucleotide binding]; DNA binding site 222523009896 UTRA domain; Region: UTRA; pfam07702 222523009897 Tetraspanin family; Region: Tetraspannin; pfam00335 222523009898 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 222523009899 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 222523009900 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 222523009901 YlzJ-like protein; Region: YlzJ; pfam14035 222523009902 Clp protease; Region: CLP_protease; pfam00574 222523009903 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 222523009904 active site 222523009905 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 222523009906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523009907 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 222523009908 Class I aldolases; Region: Aldolase_Class_I; cl17187 222523009909 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 222523009910 dimer interface [polypeptide binding]; other site 222523009911 active site 222523009912 catalytic residue [active] 222523009913 aspartate kinase I; Reviewed; Region: PRK08210 222523009914 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 222523009915 nucleotide binding site [chemical binding]; other site 222523009916 substrate binding site [chemical binding]; other site 222523009917 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 222523009918 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 222523009919 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 222523009920 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 222523009921 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 222523009922 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 222523009923 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 222523009924 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 222523009925 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 222523009926 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 222523009927 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 222523009928 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 222523009929 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 222523009930 NodB motif; other site 222523009931 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 222523009932 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 222523009933 RNase E interface [polypeptide binding]; other site 222523009934 trimer interface [polypeptide binding]; other site 222523009935 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 222523009936 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 222523009937 RNase E interface [polypeptide binding]; other site 222523009938 trimer interface [polypeptide binding]; other site 222523009939 active site 222523009940 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 222523009941 putative nucleic acid binding region [nucleotide binding]; other site 222523009942 G-X-X-G motif; other site 222523009943 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 222523009944 RNA binding site [nucleotide binding]; other site 222523009945 domain interface; other site 222523009946 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 222523009947 16S/18S rRNA binding site [nucleotide binding]; other site 222523009948 S13e-L30e interaction site [polypeptide binding]; other site 222523009949 25S rRNA binding site [nucleotide binding]; other site 222523009950 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 222523009951 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 222523009952 active site 222523009953 Riboflavin kinase; Region: Flavokinase; pfam01687 222523009954 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 222523009955 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 222523009956 RNA binding site [nucleotide binding]; other site 222523009957 active site 222523009958 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 222523009959 Protein of unknown function (DUF503); Region: DUF503; pfam04456 222523009960 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 222523009961 translation initiation factor IF-2; Region: IF-2; TIGR00487 222523009962 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 222523009963 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 222523009964 G1 box; other site 222523009965 putative GEF interaction site [polypeptide binding]; other site 222523009966 GTP/Mg2+ binding site [chemical binding]; other site 222523009967 Switch I region; other site 222523009968 G2 box; other site 222523009969 G3 box; other site 222523009970 Switch II region; other site 222523009971 G4 box; other site 222523009972 G5 box; other site 222523009973 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 222523009974 Translation-initiation factor 2; Region: IF-2; pfam11987 222523009975 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 222523009976 hypothetical protein; Provisional; Region: PRK07714 222523009977 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 222523009978 putative RNA binding cleft [nucleotide binding]; other site 222523009979 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 222523009980 NusA N-terminal domain; Region: NusA_N; pfam08529 222523009981 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 222523009982 RNA binding site [nucleotide binding]; other site 222523009983 homodimer interface [polypeptide binding]; other site 222523009984 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 222523009985 G-X-X-G motif; other site 222523009986 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 222523009987 G-X-X-G motif; other site 222523009988 ribosome maturation protein RimP; Reviewed; Region: PRK00092 222523009989 Sm and related proteins; Region: Sm_like; cl00259 222523009990 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 222523009991 putative oligomer interface [polypeptide binding]; other site 222523009992 putative RNA binding site [nucleotide binding]; other site 222523009993 DNA polymerase III PolC; Validated; Region: polC; PRK00448 222523009994 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523009995 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 222523009996 putative active site [active] 222523009997 putative NTP binding site [chemical binding]; other site 222523009998 putative nucleic acid binding site [nucleotide binding]; other site 222523009999 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 222523010000 active site 222523010001 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 222523010002 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 222523010003 generic binding surface II; other site 222523010004 generic binding surface I; other site 222523010005 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 222523010006 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 222523010007 active site 222523010008 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 222523010009 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 222523010010 active site 222523010011 catalytic site [active] 222523010012 substrate binding site [chemical binding]; other site 222523010013 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 222523010014 prolyl-tRNA synthetase; Provisional; Region: PRK09194 222523010015 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 222523010016 dimer interface [polypeptide binding]; other site 222523010017 motif 1; other site 222523010018 active site 222523010019 motif 2; other site 222523010020 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 222523010021 putative deacylase active site [active] 222523010022 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 222523010023 active site 222523010024 motif 3; other site 222523010025 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 222523010026 anticodon binding site; other site 222523010027 RIP metalloprotease RseP; Region: TIGR00054 222523010028 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 222523010029 active site 222523010030 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 222523010031 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 222523010032 protein binding site [polypeptide binding]; other site 222523010033 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 222523010034 putative substrate binding region [chemical binding]; other site 222523010035 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 222523010036 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 222523010037 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 222523010038 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 222523010039 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 222523010040 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 222523010041 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 222523010042 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 222523010043 catalytic residue [active] 222523010044 putative FPP diphosphate binding site; other site 222523010045 putative FPP binding hydrophobic cleft; other site 222523010046 dimer interface [polypeptide binding]; other site 222523010047 putative IPP diphosphate binding site; other site 222523010048 ribosome recycling factor; Reviewed; Region: frr; PRK00083 222523010049 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 222523010050 hinge region; other site 222523010051 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 222523010052 putative nucleotide binding site [chemical binding]; other site 222523010053 uridine monophosphate binding site [chemical binding]; other site 222523010054 homohexameric interface [polypeptide binding]; other site 222523010055 elongation factor Ts; Provisional; Region: tsf; PRK09377 222523010056 UBA/TS-N domain; Region: UBA; pfam00627 222523010057 Elongation factor TS; Region: EF_TS; pfam00889 222523010058 Elongation factor TS; Region: EF_TS; pfam00889 222523010059 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 222523010060 rRNA interaction site [nucleotide binding]; other site 222523010061 S8 interaction site; other site 222523010062 putative laminin-1 binding site; other site 222523010063 transcriptional repressor CodY; Validated; Region: PRK04158 222523010064 CodY GAF-like domain; Region: CodY; pfam06018 222523010065 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 222523010066 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 222523010067 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 222523010068 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 222523010069 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 222523010070 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 222523010071 active site 222523010072 HslU subunit interaction site [polypeptide binding]; other site 222523010073 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 222523010074 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 222523010075 active site 222523010076 Int/Topo IB signature motif; other site 222523010077 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 222523010078 Glucose inhibited division protein A; Region: GIDA; pfam01134 222523010079 DNA topoisomerase I; Validated; Region: PRK05582 222523010080 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 222523010081 active site 222523010082 interdomain interaction site; other site 222523010083 putative metal-binding site [ion binding]; other site 222523010084 nucleotide binding site [chemical binding]; other site 222523010085 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 222523010086 domain I; other site 222523010087 DNA binding groove [nucleotide binding] 222523010088 phosphate binding site [ion binding]; other site 222523010089 domain II; other site 222523010090 domain III; other site 222523010091 nucleotide binding site [chemical binding]; other site 222523010092 catalytic site [active] 222523010093 domain IV; other site 222523010094 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 222523010095 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 222523010096 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 222523010097 DNA protecting protein DprA; Region: dprA; TIGR00732 222523010098 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 222523010099 CoA binding domain; Region: CoA_binding; smart00881 222523010100 CoA-ligase; Region: Ligase_CoA; pfam00549 222523010101 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 222523010102 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 222523010103 CoA-ligase; Region: Ligase_CoA; pfam00549 222523010104 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 222523010105 RNA/DNA hybrid binding site [nucleotide binding]; other site 222523010106 active site 222523010107 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 222523010108 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 222523010109 GTP/Mg2+ binding site [chemical binding]; other site 222523010110 G4 box; other site 222523010111 G5 box; other site 222523010112 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 222523010113 G1 box; other site 222523010114 G1 box; other site 222523010115 GTP/Mg2+ binding site [chemical binding]; other site 222523010116 Switch I region; other site 222523010117 G2 box; other site 222523010118 G2 box; other site 222523010119 G3 box; other site 222523010120 G3 box; other site 222523010121 Switch II region; other site 222523010122 Switch II region; other site 222523010123 G4 box; other site 222523010124 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 222523010125 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523010126 Catalytic site [active] 222523010127 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 222523010128 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 222523010129 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 222523010130 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 222523010131 RimM N-terminal domain; Region: RimM; pfam01782 222523010132 PRC-barrel domain; Region: PRC; pfam05239 222523010133 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 222523010134 KH domain; Region: KH_4; pfam13083 222523010135 G-X-X-G motif; other site 222523010136 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 222523010137 signal recognition particle protein; Provisional; Region: PRK10867 222523010138 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 222523010139 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 222523010140 P loop; other site 222523010141 GTP binding site [chemical binding]; other site 222523010142 Signal peptide binding domain; Region: SRP_SPB; pfam02978 222523010143 putative DNA-binding protein; Validated; Region: PRK00118 222523010144 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 222523010145 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 222523010146 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 222523010147 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 222523010148 P loop; other site 222523010149 GTP binding site [chemical binding]; other site 222523010150 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 222523010151 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 222523010152 Walker A/P-loop; other site 222523010153 ATP binding site [chemical binding]; other site 222523010154 Q-loop/lid; other site 222523010155 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 222523010156 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 222523010157 ABC transporter signature motif; other site 222523010158 Walker B; other site 222523010159 D-loop; other site 222523010160 H-loop/switch region; other site 222523010161 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 222523010162 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 222523010163 dimerization interface [polypeptide binding]; other site 222523010164 active site 222523010165 metal binding site [ion binding]; metal-binding site 222523010166 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 222523010167 dsRNA binding site [nucleotide binding]; other site 222523010168 acyl carrier protein; Provisional; Region: acpP; PRK00982 222523010169 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 222523010170 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 222523010171 NAD(P) binding site [chemical binding]; other site 222523010172 homotetramer interface [polypeptide binding]; other site 222523010173 homodimer interface [polypeptide binding]; other site 222523010174 active site 222523010175 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 222523010176 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 222523010177 putative phosphate acyltransferase; Provisional; Region: PRK05331 222523010178 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 222523010179 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 222523010180 active site 2 [active] 222523010181 active site 1 [active] 222523010182 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 222523010183 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 222523010184 generic binding surface II; other site 222523010185 ssDNA binding site; other site 222523010186 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523010187 ATP binding site [chemical binding]; other site 222523010188 putative Mg++ binding site [ion binding]; other site 222523010189 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523010190 nucleotide binding region [chemical binding]; other site 222523010191 ATP-binding site [chemical binding]; other site 222523010192 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 222523010193 DAK2 domain; Region: Dak2; pfam02734 222523010194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 222523010195 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 222523010196 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 222523010197 Thiamine pyrophosphokinase; Region: TPK; cd07995 222523010198 active site 222523010199 dimerization interface [polypeptide binding]; other site 222523010200 thiamine binding site [chemical binding]; other site 222523010201 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 222523010202 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 222523010203 substrate binding site [chemical binding]; other site 222523010204 hexamer interface [polypeptide binding]; other site 222523010205 metal binding site [ion binding]; metal-binding site 222523010206 GTPase RsgA; Reviewed; Region: PRK00098 222523010207 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 222523010208 RNA binding site [nucleotide binding]; other site 222523010209 homodimer interface [polypeptide binding]; other site 222523010210 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 222523010211 GTPase/Zn-binding domain interface [polypeptide binding]; other site 222523010212 GTP/Mg2+ binding site [chemical binding]; other site 222523010213 G4 box; other site 222523010214 G5 box; other site 222523010215 G1 box; other site 222523010216 Switch I region; other site 222523010217 G2 box; other site 222523010218 G3 box; other site 222523010219 Switch II region; other site 222523010220 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 222523010221 Catalytic domain of Protein Kinases; Region: PKc; cd00180 222523010222 active site 222523010223 ATP binding site [chemical binding]; other site 222523010224 substrate binding site [chemical binding]; other site 222523010225 activation loop (A-loop); other site 222523010226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 222523010227 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 222523010228 PASTA domain; Region: PASTA; pfam03793 222523010229 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 222523010230 Protein phosphatase 2C; Region: PP2C; pfam00481 222523010231 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 222523010232 active site 222523010233 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 222523010234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523010235 FeS/SAM binding site; other site 222523010236 16S rRNA methyltransferase B; Provisional; Region: PRK14902 222523010237 NusB family; Region: NusB; pfam01029 222523010238 putative RNA binding site [nucleotide binding]; other site 222523010239 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523010240 S-adenosylmethionine binding site [chemical binding]; other site 222523010241 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 222523010242 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 222523010243 putative active site [active] 222523010244 putative cosubstrate binding site; other site 222523010245 substrate binding site [chemical binding]; other site 222523010246 catalytic site [active] 222523010247 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 222523010248 substrate binding site [chemical binding]; other site 222523010249 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 222523010250 active site 222523010251 catalytic residues [active] 222523010252 metal binding site [ion binding]; metal-binding site 222523010253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523010254 primosomal protein N' Region: priA; TIGR00595 222523010255 ATP binding site [chemical binding]; other site 222523010256 putative Mg++ binding site [ion binding]; other site 222523010257 helicase superfamily c-terminal domain; Region: HELICc; smart00490 222523010258 nucleotide binding region [chemical binding]; other site 222523010259 ATP-binding site [chemical binding]; other site 222523010260 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 222523010261 Flavoprotein; Region: Flavoprotein; pfam02441 222523010262 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 222523010263 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 222523010264 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 222523010265 catalytic site [active] 222523010266 G-X2-G-X-G-K; other site 222523010267 hypothetical protein; Provisional; Region: PRK04323 222523010268 hypothetical protein; Provisional; Region: PRK11820 222523010269 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 222523010270 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 222523010271 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 222523010272 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 222523010273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523010274 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 222523010275 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523010276 motif II; other site 222523010277 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 222523010278 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523010279 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 222523010280 Probable transposase; Region: OrfB_IS605; pfam01385 222523010281 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 222523010282 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 222523010283 Domain of unknown function (DUF814); Region: DUF814; pfam05670 222523010284 Protein of unknown function (DUF1311); Region: DUF1311; pfam07007 222523010285 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 222523010286 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 222523010287 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 222523010288 active site 222523010289 DinB family; Region: DinB; cl17821 222523010290 DinB superfamily; Region: DinB_2; pfam12867 222523010291 YoqO-like protein; Region: YoqO; pfam14037 222523010292 YoqO-like protein; Region: YoqO; pfam14037 222523010293 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 222523010294 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 222523010295 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523010296 active site 222523010297 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 222523010298 active site 222523010299 dimer interface [polypeptide binding]; other site 222523010300 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 222523010301 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 222523010302 heterodimer interface [polypeptide binding]; other site 222523010303 active site 222523010304 FMN binding site [chemical binding]; other site 222523010305 homodimer interface [polypeptide binding]; other site 222523010306 substrate binding site [chemical binding]; other site 222523010307 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 222523010308 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 222523010309 FAD binding pocket [chemical binding]; other site 222523010310 FAD binding motif [chemical binding]; other site 222523010311 phosphate binding motif [ion binding]; other site 222523010312 beta-alpha-beta structure motif; other site 222523010313 NAD binding pocket [chemical binding]; other site 222523010314 Iron coordination center [ion binding]; other site 222523010315 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 222523010316 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 222523010317 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 222523010318 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 222523010319 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 222523010320 ATP-grasp domain; Region: ATP-grasp_4; cl17255 222523010321 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 222523010322 IMP binding site; other site 222523010323 dimer interface [polypeptide binding]; other site 222523010324 interdomain contacts; other site 222523010325 partial ornithine binding site; other site 222523010326 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 222523010327 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 222523010328 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 222523010329 catalytic site [active] 222523010330 subunit interface [polypeptide binding]; other site 222523010331 dihydroorotase; Validated; Region: pyrC; PRK09357 222523010332 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 222523010333 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 222523010334 active site 222523010335 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 222523010336 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 222523010337 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 222523010338 uracil transporter; Provisional; Region: PRK10720 222523010339 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 222523010340 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523010341 active site 222523010342 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 222523010343 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523010344 RNA binding surface [nucleotide binding]; other site 222523010345 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 222523010346 active site 222523010347 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 222523010348 lipoprotein signal peptidase; Provisional; Region: PRK14787 222523010349 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 222523010350 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 222523010351 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 222523010352 active site 222523010353 HIGH motif; other site 222523010354 nucleotide binding site [chemical binding]; other site 222523010355 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 222523010356 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 222523010357 active site 222523010358 KMSKS motif; other site 222523010359 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 222523010360 tRNA binding surface [nucleotide binding]; other site 222523010361 anticodon binding site; other site 222523010362 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 222523010363 DivIVA protein; Region: DivIVA; pfam05103 222523010364 DivIVA domain; Region: DivI1A_domain; TIGR03544 222523010365 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 222523010366 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 222523010367 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523010368 RNA binding surface [nucleotide binding]; other site 222523010369 YGGT family; Region: YGGT; pfam02325 222523010370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 222523010371 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 222523010372 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 222523010373 catalytic residue [active] 222523010374 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 222523010375 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 222523010376 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 222523010377 sporulation sigma factor SigG; Reviewed; Region: PRK08215 222523010378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523010379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523010380 DNA binding residues [nucleotide binding] 222523010381 sporulation sigma factor SigE; Reviewed; Region: PRK08301 222523010382 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523010383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523010384 DNA binding residues [nucleotide binding] 222523010385 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 222523010386 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 222523010387 cell division protein FtsZ; Validated; Region: PRK09330 222523010388 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 222523010389 nucleotide binding site [chemical binding]; other site 222523010390 SulA interaction site; other site 222523010391 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 222523010392 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 222523010393 nucleotide binding site [chemical binding]; other site 222523010394 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 222523010395 Cell division protein FtsA; Region: FtsA; pfam14450 222523010396 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 222523010397 Cell division protein FtsQ; Region: FtsQ; pfam03799 222523010398 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 222523010399 FAD binding domain; Region: FAD_binding_4; pfam01565 222523010400 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 222523010401 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 222523010402 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 222523010403 active site 222523010404 homodimer interface [polypeptide binding]; other site 222523010405 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 222523010406 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 222523010407 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 222523010408 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523010409 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523010410 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 222523010411 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 222523010412 Mg++ binding site [ion binding]; other site 222523010413 putative catalytic motif [active] 222523010414 putative substrate binding site [chemical binding]; other site 222523010415 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 222523010416 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 222523010417 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523010418 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523010419 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 222523010420 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523010421 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523010422 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 222523010423 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523010424 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523010425 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523010426 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 222523010427 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 222523010428 Cell division protein FtsL; Region: FtsL; cl11433 222523010429 MraW methylase family; Region: Methyltransf_5; pfam01795 222523010430 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 222523010431 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 222523010432 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 222523010433 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 222523010434 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 222523010435 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 222523010436 hypothetical protein; Provisional; Region: PRK13688 222523010437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523010438 Coenzyme A binding pocket [chemical binding]; other site 222523010439 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 222523010440 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 222523010441 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 222523010442 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 222523010443 hypothetical protein; Provisional; Region: PRK13670 222523010444 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 222523010445 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 222523010446 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 222523010447 protein binding site [polypeptide binding]; other site 222523010448 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 222523010449 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 222523010450 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 222523010451 active site 222523010452 nucleophile elbow; other site 222523010453 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 222523010454 Nucleoside recognition; Region: Gate; pfam07670 222523010455 Nucleoside recognition; Region: Gate; pfam07670 222523010456 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 222523010457 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 222523010458 active site 222523010459 (T/H)XGH motif; other site 222523010460 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 222523010461 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523010462 S-adenosylmethionine binding site [chemical binding]; other site 222523010463 hypothetical protein; Provisional; Region: PRK02886 222523010464 Protein of unknown function (DUF964); Region: DUF964; pfam06133 222523010465 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523010466 catalytic core [active] 222523010467 YlbE-like protein; Region: YlbE; pfam14003 222523010468 Putative coat protein; Region: YlbD_coat; pfam14071 222523010469 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 222523010470 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 222523010471 YugN-like family; Region: YugN; pfam08868 222523010472 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 222523010473 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 222523010474 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 222523010475 Subunit I/III interface [polypeptide binding]; other site 222523010476 Subunit III/IV interface [polypeptide binding]; other site 222523010477 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 222523010478 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 222523010479 D-pathway; other site 222523010480 Putative ubiquinol binding site [chemical binding]; other site 222523010481 Low-spin heme (heme b) binding site [chemical binding]; other site 222523010482 Putative water exit pathway; other site 222523010483 Binuclear center (heme o3/CuB) [ion binding]; other site 222523010484 K-pathway; other site 222523010485 Putative proton exit pathway; other site 222523010486 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 222523010487 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 222523010488 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 222523010489 Cytochrome c; Region: Cytochrom_C; pfam00034 222523010490 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 222523010491 UbiA prenyltransferase family; Region: UbiA; pfam01040 222523010492 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 222523010493 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 222523010494 pyruvate carboxylase; Reviewed; Region: PRK12999 222523010495 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 222523010496 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 222523010497 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 222523010498 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 222523010499 active site 222523010500 catalytic residues [active] 222523010501 metal binding site [ion binding]; metal-binding site 222523010502 homodimer binding site [polypeptide binding]; other site 222523010503 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 222523010504 carboxyltransferase (CT) interaction site; other site 222523010505 biotinylation site [posttranslational modification]; other site 222523010506 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 222523010507 hypothetical protein; Provisional; Region: PRK13666 222523010508 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 222523010509 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 222523010510 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 222523010511 putative active site [active] 222523010512 PhoH-like protein; Region: PhoH; pfam02562 222523010513 hypothetical protein; Provisional; Region: PRK06733 222523010514 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 222523010515 YlaH-like protein; Region: YlaH; pfam14036 222523010516 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 222523010517 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 222523010518 G1 box; other site 222523010519 putative GEF interaction site [polypeptide binding]; other site 222523010520 GTP/Mg2+ binding site [chemical binding]; other site 222523010521 Switch I region; other site 222523010522 G2 box; other site 222523010523 G3 box; other site 222523010524 Switch II region; other site 222523010525 G4 box; other site 222523010526 G5 box; other site 222523010527 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 222523010528 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 222523010529 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 222523010530 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 222523010531 active site 222523010532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 222523010533 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 222523010534 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 222523010535 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 222523010536 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 222523010537 homodimer interface [polypeptide binding]; other site 222523010538 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523010539 catalytic residue [active] 222523010540 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 222523010541 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 222523010542 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 222523010543 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 222523010544 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 222523010545 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523010546 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 222523010547 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 222523010548 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 222523010549 E3 interaction surface; other site 222523010550 lipoyl attachment site [posttranslational modification]; other site 222523010551 e3 binding domain; Region: E3_binding; pfam02817 222523010552 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 222523010553 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 222523010554 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 222523010555 alpha subunit interface [polypeptide binding]; other site 222523010556 TPP binding site [chemical binding]; other site 222523010557 heterodimer interface [polypeptide binding]; other site 222523010558 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523010559 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 222523010560 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 222523010561 TPP-binding site [chemical binding]; other site 222523010562 heterodimer interface [polypeptide binding]; other site 222523010563 tetramer interface [polypeptide binding]; other site 222523010564 phosphorylation loop region [posttranslational modification] 222523010565 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 222523010566 active site 222523010567 catalytic residues [active] 222523010568 metal binding site [ion binding]; metal-binding site 222523010569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523010570 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523010571 active site 222523010572 motif I; other site 222523010573 motif II; other site 222523010574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523010575 hypothetical protein; Provisional; Region: PRK13667 222523010576 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 222523010577 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523010578 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 222523010579 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 222523010580 TrkA-N domain; Region: TrkA_N; pfam02254 222523010581 TrkA-C domain; Region: TrkA_C; pfam02080 222523010582 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 222523010583 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 222523010584 metal binding site [ion binding]; metal-binding site 222523010585 putative dimer interface [polypeptide binding]; other site 222523010586 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 222523010587 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 222523010588 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 222523010589 trimer interface [polypeptide binding]; other site 222523010590 active site 222523010591 substrate binding site [chemical binding]; other site 222523010592 CoA binding site [chemical binding]; other site 222523010593 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523010594 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523010595 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523010596 dimerization interface [polypeptide binding]; other site 222523010597 FOG: CBS domain [General function prediction only]; Region: COG0517 222523010598 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 222523010599 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 222523010600 Protein of unknown function (DUF458); Region: DUF458; pfam04308 222523010601 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 222523010602 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 222523010603 catalytic residues [active] 222523010604 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 222523010605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 222523010606 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 222523010607 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 222523010608 short chain dehydrogenase; Provisional; Region: PRK07677 222523010609 NAD(P) binding site [chemical binding]; other site 222523010610 substrate binding site [chemical binding]; other site 222523010611 homotetramer interface [polypeptide binding]; other site 222523010612 active site 222523010613 homodimer interface [polypeptide binding]; other site 222523010614 phosphodiesterase YaeI; Provisional; Region: PRK11340 222523010615 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 222523010616 putative active site [active] 222523010617 putative metal binding site [ion binding]; other site 222523010618 polyphosphate kinase; Provisional; Region: PRK05443 222523010619 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 222523010620 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 222523010621 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 222523010622 putative domain interface [polypeptide binding]; other site 222523010623 putative active site [active] 222523010624 catalytic site [active] 222523010625 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 222523010626 putative domain interface [polypeptide binding]; other site 222523010627 putative active site [active] 222523010628 catalytic site [active] 222523010629 exopolyphosphatase; Region: exo_poly_only; TIGR03706 222523010630 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 222523010631 YkyB-like protein; Region: YkyB; pfam14177 222523010632 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 222523010633 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523010634 I-site; other site 222523010635 active site 222523010636 metal binding site [ion binding]; metal-binding site 222523010637 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523010638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523010639 putative substrate translocation pore; other site 222523010640 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523010641 Transcriptional regulator PadR-like family; Region: PadR; cl17335 222523010642 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 222523010643 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 222523010644 THF binding site; other site 222523010645 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 222523010646 substrate binding site [chemical binding]; other site 222523010647 THF binding site; other site 222523010648 zinc-binding site [ion binding]; other site 222523010649 Competence protein J (ComJ); Region: ComJ; pfam11033 222523010650 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 222523010651 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 222523010652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523010653 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523010654 dimer interface [polypeptide binding]; other site 222523010655 phosphorylation site [posttranslational modification] 222523010656 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523010657 ATP binding site [chemical binding]; other site 222523010658 Mg2+ binding site [ion binding]; other site 222523010659 G-X-G motif; other site 222523010660 aminotransferase A; Validated; Region: PRK07683 222523010661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523010662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523010663 homodimer interface [polypeptide binding]; other site 222523010664 catalytic residue [active] 222523010665 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523010666 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523010667 DNA binding site [nucleotide binding] 222523010668 domain linker motif; other site 222523010669 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 222523010670 putative dimerization interface [polypeptide binding]; other site 222523010671 putative ligand binding site [chemical binding]; other site 222523010672 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 222523010673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523010674 dimer interface [polypeptide binding]; other site 222523010675 conserved gate region; other site 222523010676 putative PBP binding loops; other site 222523010677 ABC-ATPase subunit interface; other site 222523010678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523010679 dimer interface [polypeptide binding]; other site 222523010680 conserved gate region; other site 222523010681 putative PBP binding loops; other site 222523010682 ABC-ATPase subunit interface; other site 222523010683 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 222523010684 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 222523010685 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 222523010686 homodimer interface [polypeptide binding]; other site 222523010687 maltodextrin glucosidase; Provisional; Region: PRK10785 222523010688 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 222523010689 active site 222523010690 homodimer interface [polypeptide binding]; other site 222523010691 catalytic site [active] 222523010692 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 222523010693 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 222523010694 Ca binding site [ion binding]; other site 222523010695 active site 222523010696 catalytic site [active] 222523010697 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 222523010698 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 222523010699 Walker A/P-loop; other site 222523010700 ATP binding site [chemical binding]; other site 222523010701 Q-loop/lid; other site 222523010702 ABC transporter signature motif; other site 222523010703 Walker B; other site 222523010704 D-loop; other site 222523010705 H-loop/switch region; other site 222523010706 TOBE domain; Region: TOBE_2; pfam08402 222523010707 hypothetical protein; Provisional; Region: PRK06720 222523010708 NAD(P) binding site [chemical binding]; other site 222523010709 RDD family; Region: RDD; pfam06271 222523010710 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 222523010711 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 222523010712 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 222523010713 Predicted ATPase [General function prediction only]; Region: COG3910 222523010714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523010715 Walker A/P-loop; other site 222523010716 ATP binding site [chemical binding]; other site 222523010717 Q-loop/lid; other site 222523010718 ABC transporter signature motif; other site 222523010719 Walker B; other site 222523010720 D-loop; other site 222523010721 H-loop/switch region; other site 222523010722 putative acyltransferase; Provisional; Region: PRK05790 222523010723 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 222523010724 dimer interface [polypeptide binding]; other site 222523010725 active site 222523010726 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 222523010727 nudix motif; other site 222523010728 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 222523010729 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 222523010730 hypothetical protein; Validated; Region: PRK07668 222523010731 hypothetical protein; Validated; Region: PRK07668 222523010732 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523010733 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523010734 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 222523010735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523010736 NAD(P) binding site [chemical binding]; other site 222523010737 active site 222523010738 YvrJ protein family; Region: YvrJ; pfam12841 222523010739 Helix-turn-helix domain; Region: HTH_17; cl17695 222523010740 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523010741 active site 222523010742 Int/Topo IB signature motif; other site 222523010743 DNA binding site [nucleotide binding] 222523010744 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 222523010745 active site 222523010746 catalytic residues [active] 222523010747 DNA binding site [nucleotide binding] 222523010748 Int/Topo IB signature motif; other site 222523010749 Predicted transcriptional regulators [Transcription]; Region: COG1378 222523010750 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 222523010751 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 222523010752 C-terminal domain interface [polypeptide binding]; other site 222523010753 sugar binding site [chemical binding]; other site 222523010754 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 222523010755 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 222523010756 amino acid transporter; Region: 2A0306; TIGR00909 222523010757 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 222523010758 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 222523010759 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 222523010760 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 222523010761 Phosphotransferase enzyme family; Region: APH; pfam01636 222523010762 Predicted amidohydrolase [General function prediction only]; Region: COG0388 222523010763 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 222523010764 putative active site [active] 222523010765 catalytic triad [active] 222523010766 putative dimer interface [polypeptide binding]; other site 222523010767 transaminase; Reviewed; Region: PRK08068 222523010768 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523010769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523010770 homodimer interface [polypeptide binding]; other site 222523010771 catalytic residue [active] 222523010772 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 222523010773 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 222523010774 dimer interface [polypeptide binding]; other site 222523010775 active site 222523010776 catalytic residue [active] 222523010777 metal binding site [ion binding]; metal-binding site 222523010778 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 222523010779 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 222523010780 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 222523010781 intersubunit interface [polypeptide binding]; other site 222523010782 active site 222523010783 Zn2+ binding site [ion binding]; other site 222523010784 ARD/ARD' family; Region: ARD; pfam03079 222523010785 Cupin domain; Region: Cupin_2; pfam07883 222523010786 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 222523010787 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 222523010788 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 222523010789 Beta-lactamase; Region: Beta-lactamase; pfam00144 222523010790 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 222523010791 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 222523010792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523010793 metal binding site [ion binding]; metal-binding site 222523010794 active site 222523010795 I-site; other site 222523010796 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 222523010797 dimer interface [polypeptide binding]; other site 222523010798 FMN binding site [chemical binding]; other site 222523010799 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 222523010800 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 222523010801 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 222523010802 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 222523010803 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 222523010804 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 222523010805 dimerization domain swap beta strand [polypeptide binding]; other site 222523010806 regulatory protein interface [polypeptide binding]; other site 222523010807 active site 222523010808 regulatory phosphorylation site [posttranslational modification]; other site 222523010809 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 222523010810 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 222523010811 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 222523010812 active site turn [active] 222523010813 phosphorylation site [posttranslational modification] 222523010814 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 222523010815 HPr interaction site; other site 222523010816 glycerol kinase (GK) interaction site [polypeptide binding]; other site 222523010817 active site 222523010818 phosphorylation site [posttranslational modification] 222523010819 transcriptional antiterminator BglG; Provisional; Region: PRK09772 222523010820 CAT RNA binding domain; Region: CAT_RBD; smart01061 222523010821 PRD domain; Region: PRD; pfam00874 222523010822 PRD domain; Region: PRD; pfam00874 222523010823 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523010824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523010825 active site 222523010826 motif I; other site 222523010827 motif II; other site 222523010828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523010829 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 222523010830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523010831 DNA-binding site [nucleotide binding]; DNA binding site 222523010832 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 222523010833 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 222523010834 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 222523010835 active site 222523010836 trimer interface [polypeptide binding]; other site 222523010837 allosteric site; other site 222523010838 active site lid [active] 222523010839 hexamer (dimer of trimers) interface [polypeptide binding]; other site 222523010840 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 222523010841 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 222523010842 active site 222523010843 dimer interface [polypeptide binding]; other site 222523010844 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 222523010845 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523010846 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 222523010847 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 222523010848 Domain of unknown function (DUF309); Region: DUF309; pfam03745 222523010849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523010850 Coenzyme A binding pocket [chemical binding]; other site 222523010851 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 222523010852 active site 222523010853 Predicted secreted protein [Function unknown]; Region: COG4086 222523010854 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 222523010855 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523010856 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 222523010857 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 222523010858 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523010859 stage V sporulation protein AD; Validated; Region: PRK08304 222523010860 stage V sporulation protein AD; Provisional; Region: PRK12404 222523010861 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 222523010862 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 222523010863 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 222523010864 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 222523010865 Na2 binding site [ion binding]; other site 222523010866 putative substrate binding site 1 [chemical binding]; other site 222523010867 Na binding site 1 [ion binding]; other site 222523010868 putative substrate binding site 2 [chemical binding]; other site 222523010869 sporulation sigma factor SigF; Validated; Region: PRK05572 222523010870 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523010871 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 222523010872 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523010873 DNA binding residues [nucleotide binding] 222523010874 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 222523010875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523010876 ATP binding site [chemical binding]; other site 222523010877 Mg2+ binding site [ion binding]; other site 222523010878 G-X-G motif; other site 222523010879 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 222523010880 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 222523010881 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523010882 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 222523010883 Predicted transcriptional regulators [Transcription]; Region: COG1725 222523010884 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523010885 DNA-binding site [nucleotide binding]; DNA binding site 222523010886 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523010887 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523010888 Walker A/P-loop; other site 222523010889 ATP binding site [chemical binding]; other site 222523010890 Q-loop/lid; other site 222523010891 ABC transporter signature motif; other site 222523010892 Walker B; other site 222523010893 D-loop; other site 222523010894 H-loop/switch region; other site 222523010895 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 222523010896 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523010897 MarR family; Region: MarR; pfam01047 222523010898 MarR family; Region: MarR_2; cl17246 222523010899 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 222523010900 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 222523010901 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 222523010902 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 222523010903 oligomer interface [polypeptide binding]; other site 222523010904 metal binding site [ion binding]; metal-binding site 222523010905 metal binding site [ion binding]; metal-binding site 222523010906 putative Cl binding site [ion binding]; other site 222523010907 aspartate ring; other site 222523010908 basic sphincter; other site 222523010909 hydrophobic gate; other site 222523010910 periplasmic entrance; other site 222523010911 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 222523010912 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 222523010913 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 222523010914 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 222523010915 purine nucleoside phosphorylase; Provisional; Region: PRK08202 222523010916 phosphopentomutase; Provisional; Region: PRK05362 222523010917 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 222523010918 YtkA-like; Region: YtkA; pfam13115 222523010919 YtkA-like; Region: YtkA; pfam13115 222523010920 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 222523010921 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 222523010922 active site 222523010923 Int/Topo IB signature motif; other site 222523010924 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 222523010925 ferric uptake regulator; Provisional; Region: fur; PRK09462 222523010926 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 222523010927 metal binding site 2 [ion binding]; metal-binding site 222523010928 putative DNA binding helix; other site 222523010929 metal binding site 1 [ion binding]; metal-binding site 222523010930 dimer interface [polypeptide binding]; other site 222523010931 structural Zn2+ binding site [ion binding]; other site 222523010932 stage II sporulation protein M; Region: spo_II_M; TIGR02831 222523010933 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523010934 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523010935 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 222523010936 dimer interface [polypeptide binding]; other site 222523010937 ADP-ribose binding site [chemical binding]; other site 222523010938 active site 222523010939 nudix motif; other site 222523010940 metal binding site [ion binding]; metal-binding site 222523010941 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 222523010942 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 222523010943 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 222523010944 active site 222523010945 catalytic tetrad [active] 222523010946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 222523010947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 222523010948 active site 222523010949 catalytic tetrad [active] 222523010950 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 222523010951 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 222523010952 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 222523010953 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 222523010954 putative active site [active] 222523010955 putative metal binding site [ion binding]; other site 222523010956 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 222523010957 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 222523010958 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523010959 Predicted permease [General function prediction only]; Region: COG2056 222523010960 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 222523010961 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 222523010962 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523010963 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523010964 DNA binding site [nucleotide binding] 222523010965 domain linker motif; other site 222523010966 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 222523010967 dimerization interface [polypeptide binding]; other site 222523010968 ligand binding site [chemical binding]; other site 222523010969 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523010970 Coenzyme A binding pocket [chemical binding]; other site 222523010971 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 222523010972 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 222523010973 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 222523010974 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 222523010975 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 222523010976 catalytic motif [active] 222523010977 Zn binding site [ion binding]; other site 222523010978 RibD C-terminal domain; Region: RibD_C; cl17279 222523010979 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 222523010980 Lumazine binding domain; Region: Lum_binding; pfam00677 222523010981 Lumazine binding domain; Region: Lum_binding; pfam00677 222523010982 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 222523010983 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 222523010984 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 222523010985 dimerization interface [polypeptide binding]; other site 222523010986 active site 222523010987 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 222523010988 homopentamer interface [polypeptide binding]; other site 222523010989 active site 222523010990 biotin synthase; Validated; Region: PRK06256 222523010991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523010992 FeS/SAM binding site; other site 222523010993 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 222523010994 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 222523010995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523010996 S-adenosylmethionine binding site [chemical binding]; other site 222523010997 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 222523010998 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 222523010999 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 222523011000 substrate-cofactor binding pocket; other site 222523011001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011002 catalytic residue [active] 222523011003 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 222523011004 AAA domain; Region: AAA_26; pfam13500 222523011005 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 222523011006 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523011007 inhibitor-cofactor binding pocket; inhibition site 222523011008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011009 catalytic residue [active] 222523011010 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 222523011011 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 222523011012 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 222523011013 active site 222523011014 metal binding site [ion binding]; metal-binding site 222523011015 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 222523011016 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 222523011017 active site 222523011018 catalytic triad [active] 222523011019 oxyanion hole [active] 222523011020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523011021 dimerization interface [polypeptide binding]; other site 222523011022 putative DNA binding site [nucleotide binding]; other site 222523011023 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523011024 putative Zn2+ binding site [ion binding]; other site 222523011025 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 222523011026 ornithine carbamoyltransferase; Provisional; Region: PRK00779 222523011027 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 222523011028 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 222523011029 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 222523011030 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523011031 inhibitor-cofactor binding pocket; inhibition site 222523011032 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011033 catalytic residue [active] 222523011034 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 222523011035 nucleotide binding site [chemical binding]; other site 222523011036 N-acetyl-L-glutamate binding site [chemical binding]; other site 222523011037 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 222523011038 heterotetramer interface [polypeptide binding]; other site 222523011039 active site pocket [active] 222523011040 cleavage site 222523011041 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 222523011042 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 222523011043 YqzH-like protein; Region: YqzH; pfam14164 222523011044 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 222523011045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523011046 NAD(P) binding site [chemical binding]; other site 222523011047 active site 222523011048 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523011049 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 222523011050 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 222523011051 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 222523011052 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 222523011053 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 222523011054 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 222523011055 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 222523011056 putative L-serine binding site [chemical binding]; other site 222523011057 ribonuclease Z; Region: RNase_Z; TIGR02651 222523011058 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 222523011059 magnesium-transporting ATPase; Provisional; Region: PRK15122 222523011060 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 222523011061 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523011062 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 222523011063 Soluble P-type ATPase [General function prediction only]; Region: COG4087 222523011064 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 222523011065 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 222523011066 MgtC family; Region: MgtC; pfam02308 222523011067 DNA polymerase IV; Validated; Region: PRK01810 222523011068 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 222523011069 active site 222523011070 DNA binding site [nucleotide binding] 222523011071 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 222523011072 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 222523011073 peptidase T-like protein; Region: PepT-like; TIGR01883 222523011074 metal binding site [ion binding]; metal-binding site 222523011075 putative dimer interface [polypeptide binding]; other site 222523011076 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523011077 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523011078 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 222523011079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 222523011080 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 222523011081 Predicted membrane protein [Function unknown]; Region: COG4129 222523011082 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 222523011083 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 222523011084 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523011085 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523011086 Walker A/P-loop; other site 222523011087 ATP binding site [chemical binding]; other site 222523011088 Q-loop/lid; other site 222523011089 ABC transporter signature motif; other site 222523011090 Walker B; other site 222523011091 D-loop; other site 222523011092 H-loop/switch region; other site 222523011093 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 222523011094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523011095 dimer interface [polypeptide binding]; other site 222523011096 conserved gate region; other site 222523011097 putative PBP binding loops; other site 222523011098 ABC-ATPase subunit interface; other site 222523011099 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 222523011100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523011101 substrate binding pocket [chemical binding]; other site 222523011102 membrane-bound complex binding site; other site 222523011103 hinge residues; other site 222523011104 Disulphide isomerase; Region: Disulph_isomer; pfam06491 222523011105 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 222523011106 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 222523011107 nudix motif; other site 222523011108 Predicted membrane protein [Function unknown]; Region: COG2323 222523011109 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 222523011110 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 222523011111 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 222523011112 E3 interaction surface; other site 222523011113 lipoyl attachment site [posttranslational modification]; other site 222523011114 e3 binding domain; Region: E3_binding; pfam02817 222523011115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 222523011116 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 222523011117 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 222523011118 alpha subunit interface [polypeptide binding]; other site 222523011119 TPP binding site [chemical binding]; other site 222523011120 heterodimer interface [polypeptide binding]; other site 222523011121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523011122 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 222523011123 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 222523011124 tetramer interface [polypeptide binding]; other site 222523011125 TPP-binding site [chemical binding]; other site 222523011126 heterodimer interface [polypeptide binding]; other site 222523011127 phosphorylation loop region [posttranslational modification] 222523011128 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 222523011129 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 222523011130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523011131 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 222523011132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 222523011133 nucleotide binding site [chemical binding]; other site 222523011134 Acetokinase family; Region: Acetate_kinase; cl17229 222523011135 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 222523011136 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 222523011137 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 222523011138 NAD binding site [chemical binding]; other site 222523011139 Phe binding site; other site 222523011140 phosphate butyryltransferase; Validated; Region: PRK07742 222523011141 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 222523011142 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523011143 putative active site [active] 222523011144 heme pocket [chemical binding]; other site 222523011145 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523011146 putative active site [active] 222523011147 heme pocket [chemical binding]; other site 222523011148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523011149 Walker A motif; other site 222523011150 ATP binding site [chemical binding]; other site 222523011151 Walker B motif; other site 222523011152 arginine finger; other site 222523011153 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 222523011154 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 222523011155 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 222523011156 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 222523011157 active site 222523011158 catalytic site [active] 222523011159 metal binding site [ion binding]; metal-binding site 222523011160 dimer interface [polypeptide binding]; other site 222523011161 YycC-like protein; Region: YycC; pfam14174 222523011162 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 222523011163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523011164 active site 222523011165 phosphorylation site [posttranslational modification] 222523011166 intermolecular recognition site; other site 222523011167 dimerization interface [polypeptide binding]; other site 222523011168 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 222523011169 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 222523011170 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 222523011171 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 222523011172 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 222523011173 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 222523011174 Walker A/P-loop; other site 222523011175 ATP binding site [chemical binding]; other site 222523011176 Q-loop/lid; other site 222523011177 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 222523011178 ABC transporter signature motif; other site 222523011179 Walker B; other site 222523011180 D-loop; other site 222523011181 H-loop/switch region; other site 222523011182 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 222523011183 arginine repressor; Provisional; Region: PRK04280 222523011184 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 222523011185 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 222523011186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523011187 RNA binding surface [nucleotide binding]; other site 222523011188 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 222523011189 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 222523011190 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 222523011191 TPP-binding site; other site 222523011192 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 222523011193 PYR/PP interface [polypeptide binding]; other site 222523011194 dimer interface [polypeptide binding]; other site 222523011195 TPP binding site [chemical binding]; other site 222523011196 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 222523011197 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 222523011198 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 222523011199 substrate binding pocket [chemical binding]; other site 222523011200 chain length determination region; other site 222523011201 substrate-Mg2+ binding site; other site 222523011202 catalytic residues [active] 222523011203 aspartate-rich region 1; other site 222523011204 active site lid residues [active] 222523011205 aspartate-rich region 2; other site 222523011206 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 222523011207 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 222523011208 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 222523011209 generic binding surface II; other site 222523011210 generic binding surface I; other site 222523011211 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 222523011212 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 222523011213 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 222523011214 homodimer interface [polypeptide binding]; other site 222523011215 NADP binding site [chemical binding]; other site 222523011216 substrate binding site [chemical binding]; other site 222523011217 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 222523011218 putative RNA binding site [nucleotide binding]; other site 222523011219 Asp23 family; Region: Asp23; pfam03780 222523011220 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 222523011221 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 222523011222 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 222523011223 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 222523011224 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 222523011225 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 222523011226 carboxyltransferase (CT) interaction site; other site 222523011227 biotinylation site [posttranslational modification]; other site 222523011228 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 222523011229 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 222523011230 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 222523011231 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 222523011232 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 222523011233 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 222523011234 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 222523011235 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 222523011236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523011237 Walker A motif; other site 222523011238 ATP binding site [chemical binding]; other site 222523011239 Walker B motif; other site 222523011240 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 222523011241 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523011242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523011243 elongation factor P; Validated; Region: PRK00529 222523011244 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 222523011245 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 222523011246 RNA binding site [nucleotide binding]; other site 222523011247 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 222523011248 RNA binding site [nucleotide binding]; other site 222523011249 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 222523011250 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 222523011251 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 222523011252 active site 222523011253 Dehydroquinase class II; Region: DHquinase_II; pfam01220 222523011254 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 222523011255 trimer interface [polypeptide binding]; other site 222523011256 active site 222523011257 dimer interface [polypeptide binding]; other site 222523011258 Conserved membrane protein YqhR; Region: YqhR; pfam11085 222523011259 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 222523011260 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 222523011261 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 222523011262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523011263 motif II; other site 222523011264 manganese transport transcriptional regulator; Provisional; Region: PRK03902 222523011265 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 222523011266 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 222523011267 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 222523011268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523011269 FeS/SAM binding site; other site 222523011270 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523011271 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523011272 hypothetical protein; Validated; Region: PRK07668 222523011273 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 222523011274 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 222523011275 active site residue [active] 222523011276 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523011277 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523011278 DNA binding site [nucleotide binding] 222523011279 domain linker motif; other site 222523011280 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 222523011281 putative dimerization interface [polypeptide binding]; other site 222523011282 putative ligand binding site [chemical binding]; other site 222523011283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523011284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523011285 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 222523011286 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 222523011287 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 222523011288 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 222523011289 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 222523011290 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 222523011291 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 222523011292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523011293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523011294 Walker A/P-loop; other site 222523011295 ATP binding site [chemical binding]; other site 222523011296 Q-loop/lid; other site 222523011297 ABC transporter signature motif; other site 222523011298 Walker B; other site 222523011299 D-loop; other site 222523011300 H-loop/switch region; other site 222523011301 Predicted transcriptional regulators [Transcription]; Region: COG1725 222523011302 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523011303 DNA-binding site [nucleotide binding]; DNA binding site 222523011304 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 222523011305 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 222523011306 tetramer interface [polypeptide binding]; other site 222523011307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011308 catalytic residue [active] 222523011309 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 222523011310 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 222523011311 tetramer interface [polypeptide binding]; other site 222523011312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011313 catalytic residue [active] 222523011314 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 222523011315 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 222523011316 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 222523011317 DEAD-like helicases superfamily; Region: DEXDc; smart00487 222523011318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523011319 ATP binding site [chemical binding]; other site 222523011320 putative Mg++ binding site [ion binding]; other site 222523011321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523011322 nucleotide binding region [chemical binding]; other site 222523011323 ATP-binding site [chemical binding]; other site 222523011324 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 222523011325 YqzE-like protein; Region: YqzE; pfam14038 222523011326 shikimate kinase; Reviewed; Region: aroK; PRK00131 222523011327 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 222523011328 ADP binding site [chemical binding]; other site 222523011329 magnesium binding site [ion binding]; other site 222523011330 putative shikimate binding site; other site 222523011331 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 222523011332 ComG operon protein 7; Region: ComGG; pfam14173 222523011333 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 222523011334 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 222523011335 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 222523011336 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 222523011337 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 222523011338 Type II/IV secretion system protein; Region: T2SE; pfam00437 222523011339 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 222523011340 Walker A motif; other site 222523011341 ATP binding site [chemical binding]; other site 222523011342 Walker B motif; other site 222523011343 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523011344 putative DNA binding site [nucleotide binding]; other site 222523011345 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 222523011346 putative Zn2+ binding site [ion binding]; other site 222523011347 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 222523011348 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 222523011349 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 222523011350 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 222523011351 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 222523011352 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 222523011353 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 222523011354 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 222523011355 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 222523011356 active site 222523011357 homodimer interface [polypeptide binding]; other site 222523011358 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 222523011359 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 222523011360 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 222523011361 substrate binding pocket [chemical binding]; other site 222523011362 dimer interface [polypeptide binding]; other site 222523011363 inhibitor binding site; inhibition site 222523011364 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 222523011365 B12 binding site [chemical binding]; other site 222523011366 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 222523011367 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 222523011368 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 222523011369 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 222523011370 FAD binding site [chemical binding]; other site 222523011371 cystathionine gamma-synthase; Reviewed; Region: PRK08247 222523011372 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 222523011373 homodimer interface [polypeptide binding]; other site 222523011374 substrate-cofactor binding pocket; other site 222523011375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011376 catalytic residue [active] 222523011377 cystathionine beta-lyase; Provisional; Region: PRK08064 222523011378 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 222523011379 homodimer interface [polypeptide binding]; other site 222523011380 substrate-cofactor binding pocket; other site 222523011381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011382 catalytic residue [active] 222523011383 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 222523011384 Isochorismatase family; Region: Isochorismatase; pfam00857 222523011385 catalytic triad [active] 222523011386 conserved cis-peptide bond; other site 222523011387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523011388 dimerization interface [polypeptide binding]; other site 222523011389 putative DNA binding site [nucleotide binding]; other site 222523011390 putative Zn2+ binding site [ion binding]; other site 222523011391 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 222523011392 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 222523011393 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 222523011394 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 222523011395 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 222523011396 nucleotide binding site [chemical binding]; other site 222523011397 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 222523011398 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 222523011399 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 222523011400 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 222523011401 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 222523011402 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 222523011403 active site 222523011404 Substrate binding site; other site 222523011405 Mg++ binding site; other site 222523011406 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 222523011407 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 222523011408 active site 222523011409 metal binding site [ion binding]; metal-binding site 222523011410 substrate binding site [chemical binding]; other site 222523011411 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 222523011412 PhoU domain; Region: PhoU; pfam01895 222523011413 PhoU domain; Region: PhoU; pfam01895 222523011414 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 222523011415 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 222523011416 Walker A/P-loop; other site 222523011417 ATP binding site [chemical binding]; other site 222523011418 Q-loop/lid; other site 222523011419 ABC transporter signature motif; other site 222523011420 Walker B; other site 222523011421 D-loop; other site 222523011422 H-loop/switch region; other site 222523011423 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 222523011424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523011425 dimer interface [polypeptide binding]; other site 222523011426 conserved gate region; other site 222523011427 putative PBP binding loops; other site 222523011428 ABC-ATPase subunit interface; other site 222523011429 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 222523011430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523011431 dimer interface [polypeptide binding]; other site 222523011432 conserved gate region; other site 222523011433 putative PBP binding loops; other site 222523011434 ABC-ATPase subunit interface; other site 222523011435 PBP superfamily domain; Region: PBP_like_2; cl17296 222523011436 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523011437 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523011438 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523011439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523011440 putative substrate translocation pore; other site 222523011441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523011442 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 222523011443 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 222523011444 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 222523011445 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 222523011446 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 222523011447 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 222523011448 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 222523011449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 222523011450 metal binding site 2 [ion binding]; metal-binding site 222523011451 putative DNA binding helix; other site 222523011452 metal binding site 1 [ion binding]; metal-binding site 222523011453 dimer interface [polypeptide binding]; other site 222523011454 structural Zn2+ binding site [ion binding]; other site 222523011455 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 222523011456 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523011457 ABC-ATPase subunit interface; other site 222523011458 dimer interface [polypeptide binding]; other site 222523011459 putative PBP binding regions; other site 222523011460 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 222523011461 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 222523011462 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523011463 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523011464 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523011465 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 222523011466 endonuclease IV; Provisional; Region: PRK01060 222523011467 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 222523011468 Metal-binding active site; metal-binding site 222523011469 AP (apurinic/apyrimidinic) site pocket; other site 222523011470 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 222523011471 DNA interaction; other site 222523011472 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 222523011473 DEAD-like helicases superfamily; Region: DEXDc; smart00487 222523011474 ATP binding site [chemical binding]; other site 222523011475 Mg++ binding site [ion binding]; other site 222523011476 motif III; other site 222523011477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523011478 nucleotide binding region [chemical binding]; other site 222523011479 ATP-binding site [chemical binding]; other site 222523011480 YqfQ-like protein; Region: YqfQ; pfam14181 222523011481 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 222523011482 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 222523011483 Uncharacterized conserved protein [Function unknown]; Region: COG0327 222523011484 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 222523011485 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 222523011486 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 222523011487 Uncharacterized conserved protein [Function unknown]; Region: COG0327 222523011488 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 222523011489 Family of unknown function (DUF633); Region: DUF633; pfam04816 222523011490 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 222523011491 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 222523011492 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 222523011493 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 222523011494 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 222523011495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523011496 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 222523011497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523011498 DNA binding residues [nucleotide binding] 222523011499 DNA primase; Validated; Region: dnaG; PRK05667 222523011500 CHC2 zinc finger; Region: zf-CHC2; pfam01807 222523011501 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 222523011502 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 222523011503 active site 222523011504 metal binding site [ion binding]; metal-binding site 222523011505 interdomain interaction site; other site 222523011506 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 222523011507 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 222523011508 PEP synthetase regulatory protein; Provisional; Region: PRK05339 222523011509 HTH domain; Region: HTH_11; pfam08279 222523011510 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 222523011511 FOG: CBS domain [General function prediction only]; Region: COG0517 222523011512 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 222523011513 Recombination protein O N terminal; Region: RecO_N; pfam11967 222523011514 Recombination protein O C terminal; Region: RecO_C; pfam02565 222523011515 YqzL-like protein; Region: YqzL; pfam14006 222523011516 GTPase Era; Reviewed; Region: era; PRK00089 222523011517 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 222523011518 G1 box; other site 222523011519 GTP/Mg2+ binding site [chemical binding]; other site 222523011520 Switch I region; other site 222523011521 G2 box; other site 222523011522 Switch II region; other site 222523011523 G3 box; other site 222523011524 G4 box; other site 222523011525 G5 box; other site 222523011526 KH domain; Region: KH_2; pfam07650 222523011527 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 222523011528 active site 222523011529 catalytic motif [active] 222523011530 Zn binding site [ion binding]; other site 222523011531 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 222523011532 metal-binding heat shock protein; Provisional; Region: PRK00016 222523011533 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 222523011534 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 222523011535 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523011536 Zn2+ binding site [ion binding]; other site 222523011537 Mg2+ binding site [ion binding]; other site 222523011538 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 222523011539 PhoH-like protein; Region: PhoH; pfam02562 222523011540 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 222523011541 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 222523011542 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 222523011543 Yqey-like protein; Region: YqeY; pfam09424 222523011544 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 222523011545 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 222523011546 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 222523011547 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523011548 FeS/SAM binding site; other site 222523011549 TRAM domain; Region: TRAM; cl01282 222523011550 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 222523011551 RNA methyltransferase, RsmE family; Region: TIGR00046 222523011552 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 222523011553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523011554 S-adenosylmethionine binding site [chemical binding]; other site 222523011555 chaperone protein DnaJ; Provisional; Region: PRK14280 222523011556 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 222523011557 HSP70 interaction site [polypeptide binding]; other site 222523011558 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 222523011559 substrate binding site [polypeptide binding]; other site 222523011560 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 222523011561 Zn binding sites [ion binding]; other site 222523011562 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 222523011563 dimer interface [polypeptide binding]; other site 222523011564 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 222523011565 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 222523011566 nucleotide binding site [chemical binding]; other site 222523011567 NEF interaction site [polypeptide binding]; other site 222523011568 SBD interface [polypeptide binding]; other site 222523011569 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 222523011570 GrpE; Region: GrpE; pfam01025 222523011571 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 222523011572 dimer interface [polypeptide binding]; other site 222523011573 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 222523011574 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 222523011575 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 222523011576 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 222523011577 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523011578 FeS/SAM binding site; other site 222523011579 HemN C-terminal domain; Region: HemN_C; pfam06969 222523011580 Predicted transcriptional regulators [Transcription]; Region: COG1733 222523011581 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 222523011582 GTP-binding protein LepA; Provisional; Region: PRK05433 222523011583 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 222523011584 G1 box; other site 222523011585 putative GEF interaction site [polypeptide binding]; other site 222523011586 GTP/Mg2+ binding site [chemical binding]; other site 222523011587 Switch I region; other site 222523011588 G2 box; other site 222523011589 G3 box; other site 222523011590 Switch II region; other site 222523011591 G4 box; other site 222523011592 G5 box; other site 222523011593 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 222523011594 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 222523011595 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 222523011596 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 222523011597 germination protease; Provisional; Region: PRK02858 222523011598 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 222523011599 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 222523011600 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 222523011601 YqzM-like protein; Region: YqzM; pfam14141 222523011602 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 222523011603 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 222523011604 Competence protein; Region: Competence; pfam03772 222523011605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523011606 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 222523011607 catalytic motif [active] 222523011608 Zn binding site [ion binding]; other site 222523011609 SLBB domain; Region: SLBB; pfam10531 222523011610 comEA protein; Region: comE; TIGR01259 222523011611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 222523011612 late competence protein ComER; Validated; Region: PRK07680 222523011613 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 222523011614 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 222523011615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523011616 S-adenosylmethionine binding site [chemical binding]; other site 222523011617 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 222523011618 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523011619 Zn2+ binding site [ion binding]; other site 222523011620 Mg2+ binding site [ion binding]; other site 222523011621 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 222523011622 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 222523011623 active site 222523011624 (T/H)XGH motif; other site 222523011625 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 222523011626 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 222523011627 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 222523011628 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 222523011629 shikimate binding site; other site 222523011630 NAD(P) binding site [chemical binding]; other site 222523011631 GTPase YqeH; Provisional; Region: PRK13796 222523011632 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 222523011633 GTP/Mg2+ binding site [chemical binding]; other site 222523011634 G4 box; other site 222523011635 G5 box; other site 222523011636 G1 box; other site 222523011637 Switch I region; other site 222523011638 G2 box; other site 222523011639 G3 box; other site 222523011640 Switch II region; other site 222523011641 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 222523011642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523011643 active site 222523011644 motif I; other site 222523011645 motif II; other site 222523011646 Sporulation inhibitor A; Region: Sda; pfam08970 222523011647 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 222523011648 sporulation sigma factor SigK; Reviewed; Region: PRK05803 222523011649 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523011650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523011651 DNA binding residues [nucleotide binding] 222523011652 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 222523011653 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 222523011654 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 222523011655 synthetase active site [active] 222523011656 NTP binding site [chemical binding]; other site 222523011657 metal binding site [ion binding]; metal-binding site 222523011658 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 222523011659 dimer interface [polypeptide binding]; other site 222523011660 Alkaline phosphatase homologues; Region: alkPPc; smart00098 222523011661 active site 222523011662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523011663 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 222523011664 Coenzyme A binding pocket [chemical binding]; other site 222523011665 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523011666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523011667 DoxX; Region: DoxX; cl17842 222523011668 CHAT domain; Region: CHAT; cl17868 222523011669 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 222523011670 catalytic core [active] 222523011671 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 222523011672 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 222523011673 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 222523011674 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 222523011675 putative active site [active] 222523011676 catalytic triad [active] 222523011677 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 222523011678 putative integrin binding motif; other site 222523011679 PA/protease domain interface [polypeptide binding]; other site 222523011680 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 222523011681 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 222523011682 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 222523011683 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 222523011684 cofactor binding site; other site 222523011685 metal binding site [ion binding]; metal-binding site 222523011686 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 222523011687 aromatic arch; other site 222523011688 DCoH dimer interaction site [polypeptide binding]; other site 222523011689 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 222523011690 DCoH tetramer interaction site [polypeptide binding]; other site 222523011691 substrate binding site [chemical binding]; other site 222523011692 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 222523011693 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 222523011694 putative metal binding site [ion binding]; other site 222523011695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 222523011696 active site 222523011697 metal binding site [ion binding]; metal-binding site 222523011698 Predicted membrane protein [Function unknown]; Region: COG2259 222523011699 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 222523011700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523011701 non-specific DNA binding site [nucleotide binding]; other site 222523011702 salt bridge; other site 222523011703 sequence-specific DNA binding site [nucleotide binding]; other site 222523011704 Cupin domain; Region: Cupin_2; pfam07883 222523011705 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 222523011706 active site 2 [active] 222523011707 active site 1 [active] 222523011708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523011709 Coenzyme A binding pocket [chemical binding]; other site 222523011710 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523011711 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523011712 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 222523011713 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 222523011714 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 222523011715 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 222523011716 Walker A/P-loop; other site 222523011717 ATP binding site [chemical binding]; other site 222523011718 Q-loop/lid; other site 222523011719 ABC transporter signature motif; other site 222523011720 Walker B; other site 222523011721 D-loop; other site 222523011722 H-loop/switch region; other site 222523011723 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523011724 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523011725 ABC-ATPase subunit interface; other site 222523011726 dimer interface [polypeptide binding]; other site 222523011727 putative PBP binding regions; other site 222523011728 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 222523011729 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 222523011730 intersubunit interface [polypeptide binding]; other site 222523011731 YrhC-like protein; Region: YrhC; pfam14143 222523011732 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 222523011733 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 222523011734 putative catalytic cysteine [active] 222523011735 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 222523011736 putative active site [active] 222523011737 metal binding site [ion binding]; metal-binding site 222523011738 cystathionine beta-lyase; Provisional; Region: PRK07671 222523011739 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 222523011740 homodimer interface [polypeptide binding]; other site 222523011741 substrate-cofactor binding pocket; other site 222523011742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011743 catalytic residue [active] 222523011744 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 222523011745 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 222523011746 dimer interface [polypeptide binding]; other site 222523011747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523011748 catalytic residue [active] 222523011749 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 222523011750 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 222523011751 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523011752 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523011753 S-adenosylmethionine binding site [chemical binding]; other site 222523011754 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 222523011755 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 222523011756 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 222523011757 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 222523011758 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523011759 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 222523011760 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 222523011761 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 222523011762 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 222523011763 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 222523011764 ATP-binding site [chemical binding]; other site 222523011765 Sugar specificity; other site 222523011766 Pyrimidine base specificity; other site 222523011767 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 222523011768 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 222523011769 Peptidase family U32; Region: Peptidase_U32; pfam01136 222523011770 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 222523011771 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 222523011772 Peptidase family U32; Region: Peptidase_U32; pfam01136 222523011773 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 222523011774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523011775 S-adenosylmethionine binding site [chemical binding]; other site 222523011776 YceG-like family; Region: YceG; pfam02618 222523011777 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 222523011778 dimerization interface [polypeptide binding]; other site 222523011779 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 222523011780 hypothetical protein; Provisional; Region: PRK13678 222523011781 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 222523011782 hypothetical protein; Provisional; Region: PRK05473 222523011783 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 222523011784 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 222523011785 motif 1; other site 222523011786 active site 222523011787 motif 2; other site 222523011788 motif 3; other site 222523011789 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 222523011790 DHHA1 domain; Region: DHHA1; pfam02272 222523011791 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 222523011792 Domain of unknown function DUF20; Region: UPF0118; pfam01594 222523011793 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 222523011794 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 222523011795 AAA domain; Region: AAA_30; pfam13604 222523011796 Family description; Region: UvrD_C_2; pfam13538 222523011797 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523011798 TPR motif; other site 222523011799 TPR repeat; Region: TPR_11; pfam13414 222523011800 binding surface 222523011801 TPR repeat; Region: TPR_11; pfam13414 222523011802 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523011803 binding surface 222523011804 TPR motif; other site 222523011805 TPR repeat; Region: TPR_11; pfam13414 222523011806 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 222523011807 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 222523011808 Ligand Binding Site [chemical binding]; other site 222523011809 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 222523011810 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 222523011811 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523011812 catalytic residue [active] 222523011813 Predicted transcriptional regulator [Transcription]; Region: COG1959 222523011814 Transcriptional regulator; Region: Rrf2; pfam02082 222523011815 recombination factor protein RarA; Reviewed; Region: PRK13342 222523011816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523011817 Walker A motif; other site 222523011818 ATP binding site [chemical binding]; other site 222523011819 Walker B motif; other site 222523011820 arginine finger; other site 222523011821 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 222523011822 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 222523011823 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 222523011824 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 222523011825 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 222523011826 putative ATP binding site [chemical binding]; other site 222523011827 putative substrate interface [chemical binding]; other site 222523011828 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 222523011829 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 222523011830 dimer interface [polypeptide binding]; other site 222523011831 anticodon binding site; other site 222523011832 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 222523011833 homodimer interface [polypeptide binding]; other site 222523011834 motif 1; other site 222523011835 active site 222523011836 motif 2; other site 222523011837 GAD domain; Region: GAD; pfam02938 222523011838 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 222523011839 motif 3; other site 222523011840 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 222523011841 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 222523011842 dimer interface [polypeptide binding]; other site 222523011843 motif 1; other site 222523011844 active site 222523011845 motif 2; other site 222523011846 motif 3; other site 222523011847 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 222523011848 anticodon binding site; other site 222523011849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523011850 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 222523011851 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 222523011852 putative active site [active] 222523011853 dimerization interface [polypeptide binding]; other site 222523011854 putative tRNAtyr binding site [nucleotide binding]; other site 222523011855 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 222523011856 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523011857 Zn2+ binding site [ion binding]; other site 222523011858 Mg2+ binding site [ion binding]; other site 222523011859 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 222523011860 synthetase active site [active] 222523011861 NTP binding site [chemical binding]; other site 222523011862 metal binding site [ion binding]; metal-binding site 222523011863 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 222523011864 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 222523011865 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523011866 active site 222523011867 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 222523011868 DHH family; Region: DHH; pfam01368 222523011869 DHHA1 domain; Region: DHHA1; pfam02272 222523011870 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 222523011871 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 222523011872 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 222523011873 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 222523011874 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 222523011875 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 222523011876 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 222523011877 Protein export membrane protein; Region: SecD_SecF; pfam02355 222523011878 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 222523011879 stage V sporulation protein B; Region: spore_V_B; TIGR02900 222523011880 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 222523011881 Predicted membrane protein [Function unknown]; Region: COG2323 222523011882 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 222523011883 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 222523011884 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 222523011885 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 222523011886 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 222523011887 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 222523011888 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 222523011889 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 222523011890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523011891 Walker A motif; other site 222523011892 ATP binding site [chemical binding]; other site 222523011893 Walker B motif; other site 222523011894 arginine finger; other site 222523011895 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 222523011896 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 222523011897 RuvA N terminal domain; Region: RuvA_N; pfam01330 222523011898 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 222523011899 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 222523011900 BofC C-terminal domain; Region: BofC_C; pfam08955 222523011901 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523011902 EamA-like transporter family; Region: EamA; pfam00892 222523011903 EamA-like transporter family; Region: EamA; pfam00892 222523011904 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523011905 dimerization interface [polypeptide binding]; other site 222523011906 putative DNA binding site [nucleotide binding]; other site 222523011907 putative Zn2+ binding site [ion binding]; other site 222523011908 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 222523011909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523011910 quinolinate synthetase; Provisional; Region: PRK09375 222523011911 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 222523011912 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 222523011913 dimerization interface [polypeptide binding]; other site 222523011914 active site 222523011915 L-aspartate oxidase; Provisional; Region: PRK08071 222523011916 L-aspartate oxidase; Provisional; Region: PRK06175 222523011917 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 222523011918 cysteine desulfurase; Provisional; Region: PRK02948 222523011919 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 222523011920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523011921 catalytic residue [active] 222523011922 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 222523011923 HTH domain; Region: HTH_11; pfam08279 222523011924 3H domain; Region: 3H; pfam02829 222523011925 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 222523011926 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 222523011927 putative active site [active] 222523011928 putative FMN binding site [chemical binding]; other site 222523011929 putative substrate binding site [chemical binding]; other site 222523011930 putative catalytic residue [active] 222523011931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523011932 dimerization interface [polypeptide binding]; other site 222523011933 putative DNA binding site [nucleotide binding]; other site 222523011934 putative Zn2+ binding site [ion binding]; other site 222523011935 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 222523011936 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 222523011937 tetrameric interface [polypeptide binding]; other site 222523011938 activator binding site; other site 222523011939 NADP binding site [chemical binding]; other site 222523011940 substrate binding site [chemical binding]; other site 222523011941 catalytic residues [active] 222523011942 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523011943 dimerization interface [polypeptide binding]; other site 222523011944 putative DNA binding site [nucleotide binding]; other site 222523011945 putative Zn2+ binding site [ion binding]; other site 222523011946 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523011947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 222523011948 MOSC domain; Region: MOSC; pfam03473 222523011949 3-alpha domain; Region: 3-alpha; pfam03475 222523011950 prephenate dehydratase; Provisional; Region: PRK11898 222523011951 Prephenate dehydratase; Region: PDT; pfam00800 222523011952 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 222523011953 putative L-Phe binding site [chemical binding]; other site 222523011954 FtsX-like permease family; Region: FtsX; pfam02687 222523011955 FtsX-like permease family; Region: FtsX; pfam02687 222523011956 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523011957 FtsX-like permease family; Region: FtsX; pfam02687 222523011958 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523011959 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523011960 Walker A/P-loop; other site 222523011961 ATP binding site [chemical binding]; other site 222523011962 Q-loop/lid; other site 222523011963 ABC transporter signature motif; other site 222523011964 Walker B; other site 222523011965 D-loop; other site 222523011966 H-loop/switch region; other site 222523011967 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523011968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 222523011969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523011970 ATP binding site [chemical binding]; other site 222523011971 Mg2+ binding site [ion binding]; other site 222523011972 G-X-G motif; other site 222523011973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523011974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523011975 active site 222523011976 phosphorylation site [posttranslational modification] 222523011977 intermolecular recognition site; other site 222523011978 dimerization interface [polypeptide binding]; other site 222523011979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523011980 DNA binding site [nucleotide binding] 222523011981 GTPase CgtA; Reviewed; Region: obgE; PRK12297 222523011982 GTP1/OBG; Region: GTP1_OBG; pfam01018 222523011983 Obg GTPase; Region: Obg; cd01898 222523011984 G1 box; other site 222523011985 GTP/Mg2+ binding site [chemical binding]; other site 222523011986 Switch I region; other site 222523011987 G2 box; other site 222523011988 G3 box; other site 222523011989 Switch II region; other site 222523011990 G4 box; other site 222523011991 G5 box; other site 222523011992 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 222523011993 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 222523011994 hypothetical protein; Provisional; Region: PRK14553 222523011995 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 222523011996 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 222523011997 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 222523011998 homodimer interface [polypeptide binding]; other site 222523011999 oligonucleotide binding site [chemical binding]; other site 222523012000 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 222523012001 Peptidase family M50; Region: Peptidase_M50; pfam02163 222523012002 active site 222523012003 putative substrate binding region [chemical binding]; other site 222523012004 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523012005 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523012006 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 222523012007 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 222523012008 Switch I; other site 222523012009 Switch II; other site 222523012010 septum formation inhibitor; Reviewed; Region: minC; PRK00513 222523012011 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 222523012012 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 222523012013 rod shape-determining protein MreC; Provisional; Region: PRK13922 222523012014 rod shape-determining protein MreC; Region: MreC; pfam04085 222523012015 rod shape-determining protein MreB; Provisional; Region: PRK13927 222523012016 MreB and similar proteins; Region: MreB_like; cd10225 222523012017 nucleotide binding site [chemical binding]; other site 222523012018 Mg binding site [ion binding]; other site 222523012019 putative protofilament interaction site [polypeptide binding]; other site 222523012020 RodZ interaction site [polypeptide binding]; other site 222523012021 hypothetical protein; Reviewed; Region: PRK00024 222523012022 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 222523012023 MPN+ (JAMM) motif; other site 222523012024 Zinc-binding site [ion binding]; other site 222523012025 Maf-like protein; Region: Maf; pfam02545 222523012026 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 222523012027 active site 222523012028 dimer interface [polypeptide binding]; other site 222523012029 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 222523012030 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523012031 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523012032 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 222523012033 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 222523012034 active site 222523012035 HIGH motif; other site 222523012036 nucleotide binding site [chemical binding]; other site 222523012037 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 222523012038 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 222523012039 active site 222523012040 KMSKS motif; other site 222523012041 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 222523012042 tRNA binding surface [nucleotide binding]; other site 222523012043 anticodon binding site; other site 222523012044 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 222523012045 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 222523012046 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 222523012047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 222523012048 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 222523012049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 222523012050 inhibitor-cofactor binding pocket; inhibition site 222523012051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523012052 catalytic residue [active] 222523012053 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 222523012054 dimer interface [polypeptide binding]; other site 222523012055 active site 222523012056 Schiff base residues; other site 222523012057 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 222523012058 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 222523012059 active site 222523012060 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 222523012061 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 222523012062 domain interfaces; other site 222523012063 active site 222523012064 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 222523012065 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 222523012066 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 222523012067 tRNA; other site 222523012068 putative tRNA binding site [nucleotide binding]; other site 222523012069 putative NADP binding site [chemical binding]; other site 222523012070 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 222523012071 Transcriptional regulators [Transcription]; Region: MarR; COG1846 222523012072 MarR family; Region: MarR; pfam01047 222523012073 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 222523012074 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 222523012075 G1 box; other site 222523012076 GTP/Mg2+ binding site [chemical binding]; other site 222523012077 Switch I region; other site 222523012078 G2 box; other site 222523012079 G3 box; other site 222523012080 Switch II region; other site 222523012081 G4 box; other site 222523012082 G5 box; other site 222523012083 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 222523012084 Found in ATP-dependent protease La (LON); Region: LON; smart00464 222523012085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523012086 Walker A motif; other site 222523012087 ATP binding site [chemical binding]; other site 222523012088 Walker B motif; other site 222523012089 arginine finger; other site 222523012090 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 222523012091 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 222523012092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523012093 Walker A motif; other site 222523012094 ATP binding site [chemical binding]; other site 222523012095 Walker B motif; other site 222523012096 arginine finger; other site 222523012097 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 222523012098 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 222523012099 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 222523012100 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523012101 Walker A motif; other site 222523012102 ATP binding site [chemical binding]; other site 222523012103 Walker B motif; other site 222523012104 arginine finger; other site 222523012105 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 222523012106 trigger factor; Provisional; Region: tig; PRK01490 222523012107 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 222523012108 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 222523012109 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 222523012110 pentamer interface [polypeptide binding]; other site 222523012111 dodecaamer interface [polypeptide binding]; other site 222523012112 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 222523012113 Predicted ATPase [General function prediction only]; Region: COG5293 222523012114 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 222523012115 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 222523012116 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 222523012117 putative active site [active] 222523012118 putative metal binding site [ion binding]; other site 222523012119 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 222523012120 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 222523012121 active site 222523012122 metal binding site [ion binding]; metal-binding site 222523012123 homotetramer interface [polypeptide binding]; other site 222523012124 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 222523012125 active site 222523012126 dimerization interface [polypeptide binding]; other site 222523012127 ribonuclease PH; Reviewed; Region: rph; PRK00173 222523012128 Ribonuclease PH; Region: RNase_PH_bact; cd11362 222523012129 hexamer interface [polypeptide binding]; other site 222523012130 active site 222523012131 Sporulation and spore germination; Region: Germane; pfam10646 222523012132 Spore germination protein [General function prediction only]; Region: COG5401 222523012133 Sporulation and spore germination; Region: Germane; pfam10646 222523012134 glutamate racemase; Provisional; Region: PRK00865 222523012135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523012136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 222523012137 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 222523012138 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 222523012139 potential catalytic triad [active] 222523012140 conserved cys residue [active] 222523012141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523012142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523012143 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 222523012144 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 222523012145 potential catalytic triad [active] 222523012146 conserved cys residue [active] 222523012147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 222523012148 dimerization interface [polypeptide binding]; other site 222523012149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523012150 AAA domain; Region: AAA_23; pfam13476 222523012151 Walker A/P-loop; other site 222523012152 ATP binding site [chemical binding]; other site 222523012153 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523012154 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523012155 catalytic residues [active] 222523012156 catalytic nucleophile [active] 222523012157 Recombinase; Region: Recombinase; pfam07508 222523012158 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 222523012159 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 222523012160 pyruvate carboxylase; Region: pyruv_carbox; TIGR01235 222523012161 MjaII restriction endonuclease; Region: RE_MjaII; pfam09520 222523012162 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 222523012163 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 222523012164 cofactor binding site; other site 222523012165 DNA binding site [nucleotide binding] 222523012166 substrate interaction site [chemical binding]; other site 222523012167 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523012168 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523012169 catalytic residues [active] 222523012170 catalytic nucleophile [active] 222523012171 Recombinase; Region: Recombinase; pfam07508 222523012172 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523012173 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523012174 catalytic residues [active] 222523012175 catalytic nucleophile [active] 222523012176 Recombinase; Region: Recombinase; pfam07508 222523012177 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523012178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523012179 non-specific DNA binding site [nucleotide binding]; other site 222523012180 salt bridge; other site 222523012181 sequence-specific DNA binding site [nucleotide binding]; other site 222523012182 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 222523012183 DHH family; Region: DHH; pfam01368 222523012184 DHHA1 domain; Region: DHHA1; pfam02272 222523012185 Helix-turn-helix domain; Region: HTH_17; pfam12728 222523012186 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523012187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523012188 non-specific DNA binding site [nucleotide binding]; other site 222523012189 salt bridge; other site 222523012190 sequence-specific DNA binding site [nucleotide binding]; other site 222523012191 PemK-like protein; Region: PemK; pfam02452 222523012192 Helix-turn-helix domain; Region: HTH_19; pfam12844 222523012193 non-specific DNA binding site [nucleotide binding]; other site 222523012194 salt bridge; other site 222523012195 sequence-specific DNA binding site [nucleotide binding]; other site 222523012196 Domain of unknown function (DUF955); Region: DUF955; pfam06114 222523012197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523012198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523012199 DNA binding residues [nucleotide binding] 222523012200 putative uracil/xanthine transporter; Provisional; Region: PRK11412 222523012201 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 222523012202 active site 222523012203 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 222523012204 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 222523012205 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 222523012206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523012207 non-specific DNA binding site [nucleotide binding]; other site 222523012208 salt bridge; other site 222523012209 sequence-specific DNA binding site [nucleotide binding]; other site 222523012210 Cupin domain; Region: Cupin_2; pfam07883 222523012211 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 222523012212 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 222523012213 amphipathic channel; other site 222523012214 Asn-Pro-Ala signature motifs; other site 222523012215 Predicted transcriptional regulator [Transcription]; Region: COG1959 222523012216 Transcriptional regulator; Region: Rrf2; pfam02082 222523012217 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 222523012218 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 222523012219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523012220 Walker A/P-loop; other site 222523012221 ATP binding site [chemical binding]; other site 222523012222 Q-loop/lid; other site 222523012223 ABC transporter signature motif; other site 222523012224 Walker B; other site 222523012225 D-loop; other site 222523012226 H-loop/switch region; other site 222523012227 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 222523012228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523012229 active site 222523012230 motif I; other site 222523012231 motif II; other site 222523012232 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 222523012233 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 222523012234 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 222523012235 ligand binding site [chemical binding]; other site 222523012236 flagellar motor protein MotA; Validated; Region: PRK08124 222523012237 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 222523012238 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 222523012239 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 222523012240 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 222523012241 active site 222523012242 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 222523012243 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 222523012244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 222523012245 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 222523012246 L-aspartate oxidase; Provisional; Region: PRK06175 222523012247 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 222523012248 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 222523012249 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 222523012250 putative Iron-sulfur protein interface [polypeptide binding]; other site 222523012251 proximal heme binding site [chemical binding]; other site 222523012252 distal heme binding site [chemical binding]; other site 222523012253 putative dimer interface [polypeptide binding]; other site 222523012254 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 222523012255 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 222523012256 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 222523012257 GIY-YIG motif/motif A; other site 222523012258 active site 222523012259 catalytic site [active] 222523012260 putative DNA binding site [nucleotide binding]; other site 222523012261 metal binding site [ion binding]; metal-binding site 222523012262 UvrB/uvrC motif; Region: UVR; pfam02151 222523012263 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 222523012264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523012265 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 222523012266 catalytic residues [active] 222523012267 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 222523012268 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 222523012269 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 222523012270 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 222523012271 Ligand binding site [chemical binding]; other site 222523012272 Electron transfer flavoprotein domain; Region: ETF; pfam01012 222523012273 enoyl-CoA hydratase; Provisional; Region: PRK07658 222523012274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 222523012275 substrate binding site [chemical binding]; other site 222523012276 oxyanion hole (OAH) forming residues; other site 222523012277 trimer interface [polypeptide binding]; other site 222523012278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 222523012279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523012280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523012281 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 222523012282 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 222523012283 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 222523012284 acyl-activating enzyme (AAE) consensus motif; other site 222523012285 putative AMP binding site [chemical binding]; other site 222523012286 putative active site [active] 222523012287 putative CoA binding site [chemical binding]; other site 222523012288 DinB family; Region: DinB; pfam05163 222523012289 DinB superfamily; Region: DinB_2; pfam12867 222523012290 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 222523012291 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 222523012292 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 222523012293 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523012294 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 222523012295 Walker A/P-loop; other site 222523012296 ATP binding site [chemical binding]; other site 222523012297 Q-loop/lid; other site 222523012298 ABC transporter signature motif; other site 222523012299 Walker B; other site 222523012300 D-loop; other site 222523012301 H-loop/switch region; other site 222523012302 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523012303 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523012304 dimer interface [polypeptide binding]; other site 222523012305 phosphorylation site [posttranslational modification] 222523012306 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523012307 ATP binding site [chemical binding]; other site 222523012308 Mg2+ binding site [ion binding]; other site 222523012309 G-X-G motif; other site 222523012310 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523012311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523012312 active site 222523012313 phosphorylation site [posttranslational modification] 222523012314 intermolecular recognition site; other site 222523012315 dimerization interface [polypeptide binding]; other site 222523012316 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523012317 DNA binding site [nucleotide binding] 222523012318 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 222523012319 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 222523012320 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 222523012321 putative RNA binding site [nucleotide binding]; other site 222523012322 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 222523012323 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 222523012324 active site 222523012325 catalytic site [active] 222523012326 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 222523012327 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 222523012328 Walker A/P-loop; other site 222523012329 ATP binding site [chemical binding]; other site 222523012330 Q-loop/lid; other site 222523012331 ABC transporter signature motif; other site 222523012332 Walker B; other site 222523012333 D-loop; other site 222523012334 H-loop/switch region; other site 222523012335 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 222523012336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523012337 ABC-ATPase subunit interface; other site 222523012338 dimer interface [polypeptide binding]; other site 222523012339 putative PBP binding regions; other site 222523012340 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 222523012341 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 222523012342 intersubunit interface [polypeptide binding]; other site 222523012343 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523012344 heme-binding site [chemical binding]; other site 222523012345 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523012346 heme-binding site [chemical binding]; other site 222523012347 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523012348 heme-binding site [chemical binding]; other site 222523012349 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523012350 heme-binding site [chemical binding]; other site 222523012351 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523012352 heme-binding site [chemical binding]; other site 222523012353 heme uptake protein IsdC; Region: IsdC; TIGR03656 222523012354 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 222523012355 heme-binding site [chemical binding]; other site 222523012356 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 222523012357 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 222523012358 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 222523012359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523012360 RNA binding surface [nucleotide binding]; other site 222523012361 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 222523012362 probable active site [active] 222523012363 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 222523012364 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 222523012365 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 222523012366 MutS domain III; Region: MutS_III; pfam05192 222523012367 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 222523012368 Walker A/P-loop; other site 222523012369 ATP binding site [chemical binding]; other site 222523012370 Q-loop/lid; other site 222523012371 ABC transporter signature motif; other site 222523012372 Walker B; other site 222523012373 D-loop; other site 222523012374 H-loop/switch region; other site 222523012375 Smr domain; Region: Smr; pfam01713 222523012376 hypothetical protein; Provisional; Region: PRK08609 222523012377 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 222523012378 active site 222523012379 primer binding site [nucleotide binding]; other site 222523012380 NTP binding site [chemical binding]; other site 222523012381 metal binding triad [ion binding]; metal-binding site 222523012382 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 222523012383 active site 222523012384 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 222523012385 Colicin V production protein; Region: Colicin_V; pfam02674 222523012386 cell division protein ZapA; Provisional; Region: PRK14126 222523012387 ribonuclease HIII; Provisional; Region: PRK00996 222523012388 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 222523012389 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 222523012390 RNA/DNA hybrid binding site [nucleotide binding]; other site 222523012391 active site 222523012392 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 222523012393 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 222523012394 putative dimer interface [polypeptide binding]; other site 222523012395 putative anticodon binding site; other site 222523012396 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 222523012397 homodimer interface [polypeptide binding]; other site 222523012398 motif 1; other site 222523012399 motif 2; other site 222523012400 active site 222523012401 motif 3; other site 222523012402 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 222523012403 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 222523012404 putative tRNA-binding site [nucleotide binding]; other site 222523012405 B3/4 domain; Region: B3_4; pfam03483 222523012406 tRNA synthetase B5 domain; Region: B5; smart00874 222523012407 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 222523012408 dimer interface [polypeptide binding]; other site 222523012409 motif 1; other site 222523012410 motif 3; other site 222523012411 motif 2; other site 222523012412 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 222523012413 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 222523012414 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 222523012415 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 222523012416 dimer interface [polypeptide binding]; other site 222523012417 motif 1; other site 222523012418 active site 222523012419 motif 2; other site 222523012420 motif 3; other site 222523012421 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 222523012422 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 222523012423 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 222523012424 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 222523012425 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 222523012426 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 222523012427 CAAX protease self-immunity; Region: Abi; pfam02517 222523012428 CAAX protease self-immunity; Region: Abi; pfam02517 222523012429 RNA polymerase factor sigma-70; Validated; Region: PRK06811 222523012430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523012431 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 222523012432 putative substrate translocation pore; other site 222523012433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523012434 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 222523012435 HlyD family secretion protein; Region: HlyD_3; pfam13437 222523012436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523012437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523012438 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 222523012439 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 222523012440 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 222523012441 oligomer interface [polypeptide binding]; other site 222523012442 active site 222523012443 metal binding site [ion binding]; metal-binding site 222523012444 dUTPase; Region: dUTPase_2; pfam08761 222523012445 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 222523012446 active site 222523012447 homodimer interface [polypeptide binding]; other site 222523012448 metal binding site [ion binding]; metal-binding site 222523012449 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 222523012450 23S rRNA binding site [nucleotide binding]; other site 222523012451 L21 binding site [polypeptide binding]; other site 222523012452 L13 binding site [polypeptide binding]; other site 222523012453 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 222523012454 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 222523012455 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 222523012456 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 222523012457 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 222523012458 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 222523012459 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 222523012460 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 222523012461 active site 222523012462 dimer interface [polypeptide binding]; other site 222523012463 motif 1; other site 222523012464 motif 2; other site 222523012465 motif 3; other site 222523012466 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 222523012467 anticodon binding site; other site 222523012468 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 222523012469 primosomal protein DnaI; Reviewed; Region: PRK08939 222523012470 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 222523012471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523012472 Walker A motif; other site 222523012473 ATP binding site [chemical binding]; other site 222523012474 Walker B motif; other site 222523012475 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 222523012476 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 222523012477 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 222523012478 ATP cone domain; Region: ATP-cone; pfam03477 222523012479 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 222523012480 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 222523012481 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 222523012482 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 222523012483 dephospho-CoA kinase; Region: TIGR00152 222523012484 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 222523012485 CoA-binding site [chemical binding]; other site 222523012486 ATP-binding [chemical binding]; other site 222523012487 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 222523012488 Domain of unknown function DUF; Region: DUF204; pfam02659 222523012489 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 222523012490 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 222523012491 DNA binding site [nucleotide binding] 222523012492 catalytic residue [active] 222523012493 H2TH interface [polypeptide binding]; other site 222523012494 putative catalytic residues [active] 222523012495 turnover-facilitating residue; other site 222523012496 intercalation triad [nucleotide binding]; other site 222523012497 8OG recognition residue [nucleotide binding]; other site 222523012498 putative reading head residues; other site 222523012499 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 222523012500 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 222523012501 DNA polymerase I; Provisional; Region: PRK05755 222523012502 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 222523012503 active site 222523012504 metal binding site 1 [ion binding]; metal-binding site 222523012505 putative 5' ssDNA interaction site; other site 222523012506 metal binding site 3; metal-binding site 222523012507 metal binding site 2 [ion binding]; metal-binding site 222523012508 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 222523012509 putative DNA binding site [nucleotide binding]; other site 222523012510 putative metal binding site [ion binding]; other site 222523012511 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 222523012512 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 222523012513 active site 222523012514 DNA binding site [nucleotide binding] 222523012515 catalytic site [active] 222523012516 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523012517 dimerization interface [polypeptide binding]; other site 222523012518 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 222523012519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523012520 putative active site [active] 222523012521 heme pocket [chemical binding]; other site 222523012522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523012523 dimer interface [polypeptide binding]; other site 222523012524 phosphorylation site [posttranslational modification] 222523012525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523012526 ATP binding site [chemical binding]; other site 222523012527 Mg2+ binding site [ion binding]; other site 222523012528 G-X-G motif; other site 222523012529 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523012530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523012531 active site 222523012532 phosphorylation site [posttranslational modification] 222523012533 intermolecular recognition site; other site 222523012534 dimerization interface [polypeptide binding]; other site 222523012535 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523012536 DNA binding site [nucleotide binding] 222523012537 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 222523012538 active site 2 [active] 222523012539 active site 1 [active] 222523012540 malate dehydrogenase; Reviewed; Region: PRK06223 222523012541 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 222523012542 NAD(P) binding site [chemical binding]; other site 222523012543 dimer interface [polypeptide binding]; other site 222523012544 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523012545 substrate binding site [chemical binding]; other site 222523012546 isocitrate dehydrogenase; Reviewed; Region: PRK07006 222523012547 isocitrate dehydrogenase; Validated; Region: PRK07362 222523012548 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 222523012549 dimer interface [polypeptide binding]; other site 222523012550 Citrate synthase; Region: Citrate_synt; pfam00285 222523012551 active site 222523012552 citrylCoA binding site [chemical binding]; other site 222523012553 oxalacetate/citrate binding site [chemical binding]; other site 222523012554 coenzyme A binding site [chemical binding]; other site 222523012555 catalytic triad [active] 222523012556 Protein of unknown function (DUF441); Region: DUF441; pfam04284 222523012557 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 222523012558 Domain of unknown function DUF20; Region: UPF0118; pfam01594 222523012559 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 222523012560 pyruvate kinase; Provisional; Region: PRK06354 222523012561 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 222523012562 domain interfaces; other site 222523012563 active site 222523012564 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 222523012565 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 222523012566 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 222523012567 active site 222523012568 ADP/pyrophosphate binding site [chemical binding]; other site 222523012569 dimerization interface [polypeptide binding]; other site 222523012570 allosteric effector site; other site 222523012571 fructose-1,6-bisphosphate binding site; other site 222523012572 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 222523012573 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 222523012574 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 222523012575 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 222523012576 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 222523012577 Transcriptional regulators [Transcription]; Region: FadR; COG2186 222523012578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523012579 DNA-binding site [nucleotide binding]; DNA binding site 222523012580 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 222523012581 Malic enzyme, N-terminal domain; Region: malic; pfam00390 222523012582 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 222523012583 putative NAD(P) binding site [chemical binding]; other site 222523012584 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 222523012585 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 222523012586 active site 222523012587 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 222523012588 generic binding surface II; other site 222523012589 generic binding surface I; other site 222523012590 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 222523012591 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 222523012592 DHH family; Region: DHH; pfam01368 222523012593 DHHA1 domain; Region: DHHA1; pfam02272 222523012594 YtpI-like protein; Region: YtpI; pfam14007 222523012595 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 222523012596 Phosphotransferase enzyme family; Region: APH; pfam01636 222523012597 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523012598 active site 222523012599 ATP binding site [chemical binding]; other site 222523012600 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523012601 substrate binding site [chemical binding]; other site 222523012602 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 222523012603 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523012604 DNA-binding site [nucleotide binding]; DNA binding site 222523012605 DRTGG domain; Region: DRTGG; pfam07085 222523012606 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 222523012607 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 222523012608 active site 2 [active] 222523012609 active site 1 [active] 222523012610 metal-dependent hydrolase; Provisional; Region: PRK00685 222523012611 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 222523012612 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 222523012613 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 222523012614 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 222523012615 active site 222523012616 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 222523012617 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523012618 Coenzyme A binding pocket [chemical binding]; other site 222523012619 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523012620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523012621 Coenzyme A binding pocket [chemical binding]; other site 222523012622 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 222523012623 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 222523012624 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 222523012625 hexamer interface [polypeptide binding]; other site 222523012626 ligand binding site [chemical binding]; other site 222523012627 putative active site [active] 222523012628 NAD(P) binding site [chemical binding]; other site 222523012629 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 222523012630 classical (c) SDRs; Region: SDR_c; cd05233 222523012631 NAD(P) binding site [chemical binding]; other site 222523012632 active site 222523012633 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 222523012634 Ligand Binding Site [chemical binding]; other site 222523012635 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 222523012636 argininosuccinate lyase; Provisional; Region: PRK00855 222523012637 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 222523012638 active sites [active] 222523012639 tetramer interface [polypeptide binding]; other site 222523012640 argininosuccinate synthase; Provisional; Region: PRK13820 222523012641 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 222523012642 ANP binding site [chemical binding]; other site 222523012643 Substrate Binding Site II [chemical binding]; other site 222523012644 Substrate Binding Site I [chemical binding]; other site 222523012645 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523012646 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523012647 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523012648 EcsC protein family; Region: EcsC; pfam12787 222523012649 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 222523012650 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 222523012651 nudix motif; other site 222523012652 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 222523012653 propionate/acetate kinase; Provisional; Region: PRK12379 222523012654 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 222523012655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523012656 S-adenosylmethionine binding site [chemical binding]; other site 222523012657 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 222523012658 dimer interface [polypeptide binding]; other site 222523012659 catalytic triad [active] 222523012660 peroxidatic and resolving cysteines [active] 222523012661 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 222523012662 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 222523012663 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 222523012664 ATP-NAD kinase; Region: NAD_kinase; pfam01513 222523012665 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 222523012666 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 222523012667 active site 222523012668 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523012669 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 222523012670 dimer interface [polypeptide binding]; other site 222523012671 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 222523012672 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 222523012673 acyl-activating enzyme (AAE) consensus motif; other site 222523012674 AMP binding site [chemical binding]; other site 222523012675 active site 222523012676 CoA binding site [chemical binding]; other site 222523012677 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 222523012678 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 222523012679 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 222523012680 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 222523012681 Ligand Binding Site [chemical binding]; other site 222523012682 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 222523012683 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 222523012684 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523012685 catalytic residue [active] 222523012686 septation ring formation regulator EzrA; Provisional; Region: PRK04778 222523012687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523012688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523012689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 222523012690 dimerization interface [polypeptide binding]; other site 222523012691 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523012692 EamA-like transporter family; Region: EamA; pfam00892 222523012693 EamA-like transporter family; Region: EamA; pfam00892 222523012694 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523012695 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523012696 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 222523012697 GAF domain; Region: GAF_2; pfam13185 222523012698 methionine gamma-lyase; Provisional; Region: PRK06767 222523012699 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 222523012700 homodimer interface [polypeptide binding]; other site 222523012701 substrate-cofactor binding pocket; other site 222523012702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523012703 catalytic residue [active] 222523012704 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 222523012705 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 222523012706 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523012707 RNA binding surface [nucleotide binding]; other site 222523012708 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 222523012709 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 222523012710 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 222523012711 active site 222523012712 HIGH motif; other site 222523012713 dimer interface [polypeptide binding]; other site 222523012714 KMSKS motif; other site 222523012715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523012716 RNA binding surface [nucleotide binding]; other site 222523012717 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 222523012718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523012719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523012720 DNA binding residues [nucleotide binding] 222523012721 acetyl-CoA synthetase; Provisional; Region: PRK04319 222523012722 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 222523012723 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 222523012724 active site 222523012725 acyl-activating enzyme (AAE) consensus motif; other site 222523012726 putative CoA binding site [chemical binding]; other site 222523012727 AMP binding site [chemical binding]; other site 222523012728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523012729 Coenzyme A binding pocket [chemical binding]; other site 222523012730 FOG: CBS domain [General function prediction only]; Region: COG0517 222523012731 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 222523012732 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 222523012733 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 222523012734 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 222523012735 active site 222523012736 Zn binding site [ion binding]; other site 222523012737 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523012738 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 222523012739 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 222523012740 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 222523012741 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 222523012742 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 222523012743 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 222523012744 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 222523012745 catabolite control protein A; Region: ccpA; TIGR01481 222523012746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523012747 DNA binding site [nucleotide binding] 222523012748 domain linker motif; other site 222523012749 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 222523012750 dimerization interface [polypeptide binding]; other site 222523012751 effector binding site; other site 222523012752 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 222523012753 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 222523012754 putative dimer interface [polypeptide binding]; other site 222523012755 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 222523012756 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 222523012757 putative dimer interface [polypeptide binding]; other site 222523012758 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 222523012759 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 222523012760 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 222523012761 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 222523012762 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 222523012763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523012764 Coenzyme A binding pocket [chemical binding]; other site 222523012765 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523012766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523012767 Coenzyme A binding pocket [chemical binding]; other site 222523012768 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523012769 EamA-like transporter family; Region: EamA; pfam00892 222523012770 EamA-like transporter family; Region: EamA; pfam00892 222523012771 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 222523012772 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523012773 DNA binding residues [nucleotide binding] 222523012774 putative dimer interface [polypeptide binding]; other site 222523012775 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523012776 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 222523012777 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 222523012778 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 222523012779 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 222523012780 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 222523012781 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 222523012782 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 222523012783 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 222523012784 active site 222523012785 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 222523012786 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 222523012787 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 222523012788 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 222523012789 putative tRNA-binding site [nucleotide binding]; other site 222523012790 hypothetical protein; Provisional; Region: PRK13668 222523012791 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523012792 catalytic residues [active] 222523012793 NTPase; Reviewed; Region: PRK03114 222523012794 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 222523012795 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 222523012796 oligomer interface [polypeptide binding]; other site 222523012797 active site 222523012798 metal binding site [ion binding]; metal-binding site 222523012799 Predicted small secreted protein [Function unknown]; Region: COG5584 222523012800 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523012801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523012802 S-adenosylmethionine binding site [chemical binding]; other site 222523012803 YtzH-like protein; Region: YtzH; pfam14165 222523012804 Phosphotransferase enzyme family; Region: APH; pfam01636 222523012805 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523012806 active site 222523012807 substrate binding site [chemical binding]; other site 222523012808 ATP binding site [chemical binding]; other site 222523012809 pullulanase, type I; Region: pulA_typeI; TIGR02104 222523012810 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 222523012811 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 222523012812 Ca binding site [ion binding]; other site 222523012813 active site 222523012814 catalytic site [active] 222523012815 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 222523012816 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 222523012817 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 222523012818 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 222523012819 dipeptidase PepV; Reviewed; Region: PRK07318 222523012820 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 222523012821 active site 222523012822 metal binding site [ion binding]; metal-binding site 222523012823 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 222523012824 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 222523012825 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523012826 RNA binding surface [nucleotide binding]; other site 222523012827 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 222523012828 active site 222523012829 uracil binding [chemical binding]; other site 222523012830 stage V sporulation protein B; Region: spore_V_B; TIGR02900 222523012831 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 222523012832 HI0933-like protein; Region: HI0933_like; pfam03486 222523012833 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523012834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523012835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523012836 putative substrate translocation pore; other site 222523012837 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523012838 dimerization interface [polypeptide binding]; other site 222523012839 putative DNA binding site [nucleotide binding]; other site 222523012840 putative Zn2+ binding site [ion binding]; other site 222523012841 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 222523012842 putative hydrophobic ligand binding site [chemical binding]; other site 222523012843 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 222523012844 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 222523012845 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 222523012846 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 222523012847 glucose-1-dehydrogenase; Provisional; Region: PRK08936 222523012848 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 222523012849 NAD binding site [chemical binding]; other site 222523012850 homodimer interface [polypeptide binding]; other site 222523012851 active site 222523012852 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 222523012853 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 222523012854 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 222523012855 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 222523012856 MoaE interaction surface [polypeptide binding]; other site 222523012857 MoeB interaction surface [polypeptide binding]; other site 222523012858 thiocarboxylated glycine; other site 222523012859 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 222523012860 MoaE homodimer interface [polypeptide binding]; other site 222523012861 MoaD interaction [polypeptide binding]; other site 222523012862 active site residues [active] 222523012863 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 222523012864 Walker A motif; other site 222523012865 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 222523012866 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 222523012867 dimer interface [polypeptide binding]; other site 222523012868 putative functional site; other site 222523012869 putative MPT binding site; other site 222523012870 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 222523012871 trimer interface [polypeptide binding]; other site 222523012872 dimer interface [polypeptide binding]; other site 222523012873 putative active site [active] 222523012874 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 222523012875 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 222523012876 ATP binding site [chemical binding]; other site 222523012877 substrate interface [chemical binding]; other site 222523012878 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 222523012879 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523012880 FeS/SAM binding site; other site 222523012881 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 222523012882 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523012883 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 222523012884 active site residue [active] 222523012885 homoserine O-acetyltransferase; Provisional; Region: PRK06765 222523012886 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 222523012887 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 222523012888 Spore germination protein; Region: Spore_permease; pfam03845 222523012889 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 222523012890 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 222523012891 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 222523012892 putative nucleotide binding site [chemical binding]; other site 222523012893 putative metal binding site [ion binding]; other site 222523012894 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523012895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523012896 Coenzyme A binding pocket [chemical binding]; other site 222523012897 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 222523012898 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 222523012899 HIGH motif; other site 222523012900 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 222523012901 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 222523012902 active site 222523012903 KMSKS motif; other site 222523012904 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 222523012905 tRNA binding surface [nucleotide binding]; other site 222523012906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523012907 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523012908 putative substrate translocation pore; other site 222523012909 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 222523012910 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 222523012911 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 222523012912 TrkA-C domain; Region: TrkA_C; pfam02080 222523012913 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 222523012914 Int/Topo IB signature motif; other site 222523012915 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523012916 FtsX-like permease family; Region: FtsX; pfam02687 222523012917 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523012918 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523012919 Walker A/P-loop; other site 222523012920 ATP binding site [chemical binding]; other site 222523012921 Q-loop/lid; other site 222523012922 ABC transporter signature motif; other site 222523012923 Walker B; other site 222523012924 D-loop; other site 222523012925 H-loop/switch region; other site 222523012926 Predicted membrane protein [Function unknown]; Region: COG2311 222523012927 Protein of unknown function (DUF418); Region: DUF418; cl12135 222523012928 Protein of unknown function (DUF418); Region: DUF418; pfam04235 222523012929 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 222523012930 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 222523012931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523012932 FeS/SAM binding site; other site 222523012933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523012934 S-adenosylmethionine binding site [chemical binding]; other site 222523012935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523012936 Walker A/P-loop; other site 222523012937 ATP binding site [chemical binding]; other site 222523012938 Q-loop/lid; other site 222523012939 ABC transporter signature motif; other site 222523012940 aspartate racemase; Region: asp_race; TIGR00035 222523012941 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 222523012942 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 222523012943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523012944 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 222523012945 dimer interface [polypeptide binding]; other site 222523012946 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 222523012947 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 222523012948 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 222523012949 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 222523012950 ABC1 family; Region: ABC1; pfam03109 222523012951 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 222523012952 active site 222523012953 ATP binding site [chemical binding]; other site 222523012954 Uncharacterized conserved protein [Function unknown]; Region: COG3937 222523012955 hypothetical protein; Provisional; Region: PRK10279 222523012956 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 222523012957 nucleophile elbow; other site 222523012958 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 222523012959 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 222523012960 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 222523012961 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 222523012962 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 222523012963 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523012964 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 222523012965 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 222523012966 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 222523012967 trimer interface [polypeptide binding]; other site 222523012968 putative metal binding site [ion binding]; other site 222523012969 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 222523012970 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 222523012971 active site 222523012972 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 222523012973 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 222523012974 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 222523012975 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 222523012976 GTP binding site; other site 222523012977 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 222523012978 MPT binding site; other site 222523012979 trimer interface [polypeptide binding]; other site 222523012980 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523012981 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523012982 S-adenosylmethionine synthetase; Validated; Region: PRK05250 222523012983 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 222523012984 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 222523012985 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 222523012986 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 222523012987 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 222523012988 active site 222523012989 substrate-binding site [chemical binding]; other site 222523012990 metal-binding site [ion binding] 222523012991 ATP binding site [chemical binding]; other site 222523012992 ATP synthase I chain; Region: ATP_synt_I; pfam03899 222523012993 EamA-like transporter family; Region: EamA; pfam00892 222523012994 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 222523012995 EamA-like transporter family; Region: EamA; pfam00892 222523012996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 222523012997 Uncharacterized conserved protein [Function unknown]; Region: COG0327 222523012998 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 222523012999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523013000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523013001 ATP binding site [chemical binding]; other site 222523013002 Mg2+ binding site [ion binding]; other site 222523013003 G-X-G motif; other site 222523013004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523013005 dimer interface [polypeptide binding]; other site 222523013006 phosphorylation site [posttranslational modification] 222523013007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523013008 ATP binding site [chemical binding]; other site 222523013009 Mg2+ binding site [ion binding]; other site 222523013010 G-X-G motif; other site 222523013011 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 222523013012 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 222523013013 Secretory lipase; Region: LIP; pfam03583 222523013014 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 222523013015 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 222523013016 Sulfatase; Region: Sulfatase; pfam00884 222523013017 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 222523013018 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 222523013019 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 222523013020 NMT1-like family; Region: NMT1_2; pfam13379 222523013021 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 222523013022 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 222523013023 Walker A/P-loop; other site 222523013024 ATP binding site [chemical binding]; other site 222523013025 Q-loop/lid; other site 222523013026 ABC transporter signature motif; other site 222523013027 Walker B; other site 222523013028 D-loop; other site 222523013029 H-loop/switch region; other site 222523013030 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 222523013031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523013032 dimer interface [polypeptide binding]; other site 222523013033 conserved gate region; other site 222523013034 putative PBP binding loops; other site 222523013035 ABC-ATPase subunit interface; other site 222523013036 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 222523013037 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523013038 motif II; other site 222523013039 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 222523013040 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 222523013041 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 222523013042 nudix motif; other site 222523013043 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 222523013044 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 222523013045 S-ribosylhomocysteinase; Provisional; Region: PRK02260 222523013046 Haemolytic domain; Region: Haemolytic; pfam01809 222523013047 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 222523013048 active site clefts [active] 222523013049 zinc binding site [ion binding]; other site 222523013050 dimer interface [polypeptide binding]; other site 222523013051 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 222523013052 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 222523013053 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 222523013054 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 222523013055 S-layer homology domain; Region: SLH; pfam00395 222523013056 S-layer homology domain; Region: SLH; pfam00395 222523013057 S-layer homology domain; Region: SLH; pfam00395 222523013058 Excalibur calcium-binding domain; Region: Excalibur; smart00894 222523013059 Uncharacterized conserved protein [Function unknown]; Region: COG1434 222523013060 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 222523013061 putative active site [active] 222523013062 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523013063 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523013064 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523013065 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523013066 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 222523013067 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 222523013068 Predicted membrane protein [Function unknown]; Region: COG3766 222523013069 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 222523013070 hypothetical protein; Provisional; Region: PRK12473 222523013071 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 222523013072 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 222523013073 G1 box; other site 222523013074 GTP/Mg2+ binding site [chemical binding]; other site 222523013075 Switch I region; other site 222523013076 G2 box; other site 222523013077 G3 box; other site 222523013078 Switch II region; other site 222523013079 G4 box; other site 222523013080 G5 box; other site 222523013081 Nucleoside recognition; Region: Gate; pfam07670 222523013082 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 222523013083 Nucleoside recognition; Region: Gate; pfam07670 222523013084 FeoA domain; Region: FeoA; pfam04023 222523013085 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 222523013086 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523013087 dimerization interface [polypeptide binding]; other site 222523013088 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523013089 dimer interface [polypeptide binding]; other site 222523013090 phosphorylation site [posttranslational modification] 222523013091 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523013092 ATP binding site [chemical binding]; other site 222523013093 Mg2+ binding site [ion binding]; other site 222523013094 G-X-G motif; other site 222523013095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523013096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523013097 active site 222523013098 phosphorylation site [posttranslational modification] 222523013099 intermolecular recognition site; other site 222523013100 dimerization interface [polypeptide binding]; other site 222523013101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523013102 DNA binding site [nucleotide binding] 222523013103 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 222523013104 active site 222523013105 catalytic site [active] 222523013106 S-layer homology domain; Region: SLH; pfam00395 222523013107 S-layer homology domain; Region: SLH; pfam00395 222523013108 S-layer homology domain; Region: SLH; pfam00395 222523013109 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 222523013110 putative active site [active] 222523013111 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 222523013112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523013113 active site 222523013114 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 222523013115 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 222523013116 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523013117 active site 222523013118 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 222523013119 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 222523013120 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 222523013121 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 222523013122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523013123 S-adenosylmethionine binding site [chemical binding]; other site 222523013124 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523013125 FtsX-like permease family; Region: FtsX; pfam02687 222523013126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523013127 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523013128 Walker A/P-loop; other site 222523013129 ATP binding site [chemical binding]; other site 222523013130 Q-loop/lid; other site 222523013131 ABC transporter signature motif; other site 222523013132 Walker B; other site 222523013133 D-loop; other site 222523013134 H-loop/switch region; other site 222523013135 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 222523013136 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 222523013137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 222523013138 Predicted integral membrane protein [Function unknown]; Region: COG5658 222523013139 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 222523013140 SdpI/YhfL protein family; Region: SdpI; pfam13630 222523013141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523013142 dimerization interface [polypeptide binding]; other site 222523013143 putative DNA binding site [nucleotide binding]; other site 222523013144 putative Zn2+ binding site [ion binding]; other site 222523013145 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523013146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523013147 active site 222523013148 phosphorylation site [posttranslational modification] 222523013149 intermolecular recognition site; other site 222523013150 dimerization interface [polypeptide binding]; other site 222523013151 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523013152 DNA binding site [nucleotide binding] 222523013153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523013154 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 222523013155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523013156 ATP binding site [chemical binding]; other site 222523013157 Mg2+ binding site [ion binding]; other site 222523013158 G-X-G motif; other site 222523013159 FtsX-like permease family; Region: FtsX; pfam02687 222523013160 FtsX-like permease family; Region: FtsX; pfam02687 222523013161 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523013162 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523013163 Walker A/P-loop; other site 222523013164 ATP binding site [chemical binding]; other site 222523013165 Q-loop/lid; other site 222523013166 ABC transporter signature motif; other site 222523013167 Walker B; other site 222523013168 D-loop; other site 222523013169 H-loop/switch region; other site 222523013170 FtsX-like permease family; Region: FtsX; pfam02687 222523013171 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523013172 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523013173 GntP family permease; Region: GntP_permease; pfam02447 222523013174 fructuronate transporter; Provisional; Region: PRK10034; cl15264 222523013175 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 222523013176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 222523013177 DNA-binding site [nucleotide binding]; DNA binding site 222523013178 UTRA domain; Region: UTRA; pfam07702 222523013179 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 222523013180 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 222523013181 substrate binding site [chemical binding]; other site 222523013182 ATP binding site [chemical binding]; other site 222523013183 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 222523013184 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 222523013185 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523013186 catalytic residue [active] 222523013187 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 222523013188 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 222523013189 active site 222523013190 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 222523013191 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 222523013192 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 222523013193 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523013194 HAMP domain; Region: HAMP; pfam00672 222523013195 dimerization interface [polypeptide binding]; other site 222523013196 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523013197 dimer interface [polypeptide binding]; other site 222523013198 phosphorylation site [posttranslational modification] 222523013199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523013200 ATP binding site [chemical binding]; other site 222523013201 Mg2+ binding site [ion binding]; other site 222523013202 G-X-G motif; other site 222523013203 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523013204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523013205 active site 222523013206 phosphorylation site [posttranslational modification] 222523013207 intermolecular recognition site; other site 222523013208 dimerization interface [polypeptide binding]; other site 222523013209 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523013210 DNA binding site [nucleotide binding] 222523013211 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 222523013212 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 222523013213 active site 222523013214 octamer interface [polypeptide binding]; other site 222523013215 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 222523013216 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 222523013217 acyl-activating enzyme (AAE) consensus motif; other site 222523013218 putative AMP binding site [chemical binding]; other site 222523013219 putative active site [active] 222523013220 putative CoA binding site [chemical binding]; other site 222523013221 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 222523013222 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 222523013223 substrate binding site [chemical binding]; other site 222523013224 oxyanion hole (OAH) forming residues; other site 222523013225 trimer interface [polypeptide binding]; other site 222523013226 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 222523013227 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 222523013228 nucleophilic elbow; other site 222523013229 catalytic triad; other site 222523013230 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 222523013231 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 222523013232 dimer interface [polypeptide binding]; other site 222523013233 tetramer interface [polypeptide binding]; other site 222523013234 PYR/PP interface [polypeptide binding]; other site 222523013235 TPP binding site [chemical binding]; other site 222523013236 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 222523013237 TPP-binding site; other site 222523013238 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 222523013239 chorismate binding enzyme; Region: Chorismate_bind; cl10555 222523013240 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 222523013241 UbiA prenyltransferase family; Region: UbiA; pfam01040 222523013242 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 222523013243 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 222523013244 DNA-binding site [nucleotide binding]; DNA binding site 222523013245 RNA-binding motif; other site 222523013246 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 222523013247 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 222523013248 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523013249 DNA binding residues [nucleotide binding] 222523013250 dimer interface [polypeptide binding]; other site 222523013251 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 222523013252 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 222523013253 active site flap/lid [active] 222523013254 nucleophilic elbow; other site 222523013255 catalytic triad [active] 222523013256 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 222523013257 homodimer interface [polypeptide binding]; other site 222523013258 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 222523013259 active site pocket [active] 222523013260 glycogen synthase; Provisional; Region: glgA; PRK00654 222523013261 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 222523013262 ADP-binding pocket [chemical binding]; other site 222523013263 homodimer interface [polypeptide binding]; other site 222523013264 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 222523013265 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 222523013266 ligand binding site; other site 222523013267 oligomer interface; other site 222523013268 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 222523013269 dimer interface [polypeptide binding]; other site 222523013270 N-terminal domain interface [polypeptide binding]; other site 222523013271 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 222523013272 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 222523013273 ligand binding site; other site 222523013274 oligomer interface; other site 222523013275 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 222523013276 dimer interface [polypeptide binding]; other site 222523013277 N-terminal domain interface [polypeptide binding]; other site 222523013278 sulfate 1 binding site; other site 222523013279 glycogen branching enzyme; Provisional; Region: PRK12313 222523013280 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 222523013281 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 222523013282 active site 222523013283 catalytic site [active] 222523013284 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 222523013285 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 222523013286 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 222523013287 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 222523013288 putative active site [active] 222523013289 catalytic triad [active] 222523013290 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 222523013291 PA/protease domain interface [polypeptide binding]; other site 222523013292 putative integrin binding motif; other site 222523013293 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 222523013294 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 222523013295 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 222523013296 dockerin binding interface; other site 222523013297 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 222523013298 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 222523013299 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523013300 NAD binding site [chemical binding]; other site 222523013301 dimer interface [polypeptide binding]; other site 222523013302 substrate binding site [chemical binding]; other site 222523013303 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 222523013304 MgtC family; Region: MgtC; pfam02308 222523013305 Ion channel; Region: Ion_trans_2; pfam07885 222523013306 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 222523013307 TrkA-N domain; Region: TrkA_N; pfam02254 222523013308 YugN-like family; Region: YugN; pfam08868 222523013309 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 222523013310 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 222523013311 active site 222523013312 dimer interface [polypeptide binding]; other site 222523013313 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 222523013314 dimer interface [polypeptide binding]; other site 222523013315 active site 222523013316 Domain of unknown function (DUF378); Region: DUF378; pfam04070 222523013317 general stress protein 13; Validated; Region: PRK08059 222523013318 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 222523013319 RNA binding site [nucleotide binding]; other site 222523013320 hypothetical protein; Validated; Region: PRK07682 222523013321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523013322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523013323 homodimer interface [polypeptide binding]; other site 222523013324 catalytic residue [active] 222523013325 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523013326 AsnC family; Region: AsnC_trans_reg; pfam01037 222523013327 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 222523013328 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 222523013329 dimerization interface [polypeptide binding]; other site 222523013330 ligand binding site [chemical binding]; other site 222523013331 NADP binding site [chemical binding]; other site 222523013332 catalytic site [active] 222523013333 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 222523013334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 222523013335 nucleophilic elbow; other site 222523013336 catalytic triad; other site 222523013337 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 222523013338 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 222523013339 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 222523013340 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523013341 homodimer interface [polypeptide binding]; other site 222523013342 catalytic residue [active] 222523013343 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 222523013344 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 222523013345 E-class dimer interface [polypeptide binding]; other site 222523013346 P-class dimer interface [polypeptide binding]; other site 222523013347 active site 222523013348 Cu2+ binding site [ion binding]; other site 222523013349 Zn2+ binding site [ion binding]; other site 222523013350 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 222523013351 Kinase associated protein B; Region: KapB; pfam08810 222523013352 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 222523013353 active site 222523013354 catalytic site [active] 222523013355 substrate binding site [chemical binding]; other site 222523013356 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 222523013357 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 222523013358 transmembrane helices; other site 222523013359 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 222523013360 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 222523013361 active site 222523013362 glycyl-tRNA synthetase; Provisional; Region: PRK04173 222523013363 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 222523013364 motif 1; other site 222523013365 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 222523013366 active site 222523013367 motif 2; other site 222523013368 motif 3; other site 222523013369 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 222523013370 anticodon binding site; other site 222523013371 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 222523013372 CoenzymeA binding site [chemical binding]; other site 222523013373 subunit interaction site [polypeptide binding]; other site 222523013374 PHB binding site; other site 222523013375 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 222523013376 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 222523013377 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 222523013378 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 222523013379 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 222523013380 active site 222523013381 tetramer interface; other site 222523013382 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 222523013383 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 222523013384 active site 222523013385 substrate binding site [chemical binding]; other site 222523013386 metal binding site [ion binding]; metal-binding site 222523013387 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 222523013388 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 222523013389 multifunctional aminopeptidase A; Provisional; Region: PRK00913 222523013390 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 222523013391 interface (dimer of trimers) [polypeptide binding]; other site 222523013392 Substrate-binding/catalytic site; other site 222523013393 Zn-binding sites [ion binding]; other site 222523013394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 222523013395 Putative membrane protein; Region: YuiB; pfam14068 222523013396 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 222523013397 nudix motif; other site 222523013398 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 222523013399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523013400 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 222523013401 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523013402 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523013403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 222523013404 H+ Antiporter protein; Region: 2A0121; TIGR00900 222523013405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523013406 putative substrate translocation pore; other site 222523013407 Helix-turn-helix domain; Region: HTH_36; pfam13730 222523013408 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 222523013409 Protein of unknown function (DUF523); Region: DUF523; pfam04463 222523013410 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 222523013411 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 222523013412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 222523013413 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 222523013414 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 222523013415 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 222523013416 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 222523013417 hypothetical protein; Provisional; Region: PRK13669 222523013418 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 222523013419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523013420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523013421 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 222523013422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523013423 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523013424 Walker A/P-loop; other site 222523013425 ATP binding site [chemical binding]; other site 222523013426 Q-loop/lid; other site 222523013427 ABC transporter signature motif; other site 222523013428 Walker B; other site 222523013429 D-loop; other site 222523013430 H-loop/switch region; other site 222523013431 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 222523013432 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 222523013433 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 222523013434 PhnA protein; Region: PhnA; pfam03831 222523013435 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 222523013436 CAAX protease self-immunity; Region: Abi; pfam02517 222523013437 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 222523013438 active site 222523013439 NTP binding site [chemical binding]; other site 222523013440 metal binding triad [ion binding]; metal-binding site 222523013441 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 222523013442 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 222523013443 NifU-like domain; Region: NifU; pfam01106 222523013444 spore coat protein YutH; Region: spore_yutH; TIGR02905 222523013445 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 222523013446 tetramer interfaces [polypeptide binding]; other site 222523013447 binuclear metal-binding site [ion binding]; other site 222523013448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 222523013449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523013450 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 222523013451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523013452 active site 222523013453 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 222523013454 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 222523013455 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523013456 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 222523013457 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 222523013458 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 222523013459 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523013460 active site 222523013461 motif I; other site 222523013462 motif II; other site 222523013463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523013464 Predicted transcriptional regulator [Transcription]; Region: COG2345 222523013465 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523013466 putative Zn2+ binding site [ion binding]; other site 222523013467 putative DNA binding site [nucleotide binding]; other site 222523013468 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 222523013469 Uncharacterized conserved protein [Function unknown]; Region: COG2445 222523013470 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 222523013471 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 222523013472 putative active site [active] 222523013473 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 222523013474 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 222523013475 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523013476 RNA binding surface [nucleotide binding]; other site 222523013477 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 222523013478 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 222523013479 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523013480 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 222523013481 DNA binding residues [nucleotide binding] 222523013482 dimer interface [polypeptide binding]; other site 222523013483 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 222523013484 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 222523013485 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 222523013486 catalytic core [active] 222523013487 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 222523013488 putative deacylase active site [active] 222523013489 lipoyl synthase; Provisional; Region: PRK05481 222523013490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523013491 FeS/SAM binding site; other site 222523013492 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523013493 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523013494 sporulation protein YunB; Region: spo_yunB; TIGR02832 222523013495 Uncharacterized conserved protein [Function unknown]; Region: COG3377 222523013496 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 222523013497 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 222523013498 active site 222523013499 metal binding site [ion binding]; metal-binding site 222523013500 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 222523013501 Predicted transcriptional regulators [Transcription]; Region: COG1695 222523013502 Transcriptional regulator PadR-like family; Region: PadR; cl17335 222523013503 VanZ like family; Region: VanZ; pfam04892 222523013504 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 222523013505 FeS assembly protein SufB; Region: sufB; TIGR01980 222523013506 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 222523013507 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 222523013508 trimerization site [polypeptide binding]; other site 222523013509 active site 222523013510 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 222523013511 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 222523013512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 222523013513 catalytic residue [active] 222523013514 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 222523013515 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 222523013516 FeS assembly protein SufD; Region: sufD; TIGR01981 222523013517 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 222523013518 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 222523013519 Walker A/P-loop; other site 222523013520 ATP binding site [chemical binding]; other site 222523013521 Q-loop/lid; other site 222523013522 ABC transporter signature motif; other site 222523013523 Walker B; other site 222523013524 D-loop; other site 222523013525 H-loop/switch region; other site 222523013526 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 222523013527 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 222523013528 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 222523013529 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 222523013530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523013531 ABC-ATPase subunit interface; other site 222523013532 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 222523013533 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 222523013534 Walker A/P-loop; other site 222523013535 ATP binding site [chemical binding]; other site 222523013536 Q-loop/lid; other site 222523013537 ABC transporter signature motif; other site 222523013538 Walker B; other site 222523013539 D-loop; other site 222523013540 H-loop/switch region; other site 222523013541 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 222523013542 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523013543 catalytic residues [active] 222523013544 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 222523013545 putative active site [active] 222523013546 putative metal binding site [ion binding]; other site 222523013547 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 222523013548 lipoyl attachment site [posttranslational modification]; other site 222523013549 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 222523013550 ArsC family; Region: ArsC; pfam03960 222523013551 putative ArsC-like catalytic residues; other site 222523013552 putative TRX-like catalytic residues [active] 222523013553 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 222523013554 active site 222523013555 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 222523013556 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 222523013557 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 222523013558 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 222523013559 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523013560 NAD binding site [chemical binding]; other site 222523013561 dimer interface [polypeptide binding]; other site 222523013562 substrate binding site [chemical binding]; other site 222523013563 Coat F domain; Region: Coat_F; pfam07875 222523013564 CAAX protease self-immunity; Region: Abi; pfam02517 222523013565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523013566 WHG domain; Region: WHG; pfam13305 222523013567 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 222523013568 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 222523013569 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 222523013570 active site 222523013571 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 222523013572 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 222523013573 dimer interface [polypeptide binding]; other site 222523013574 active site 222523013575 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 222523013576 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 222523013577 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 222523013578 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 222523013579 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 222523013580 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 222523013581 substrate binding site [chemical binding]; other site 222523013582 oxyanion hole (OAH) forming residues; other site 222523013583 YuzL-like protein; Region: YuzL; pfam14115 222523013584 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523013585 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 222523013586 Proline dehydrogenase; Region: Pro_dh; cl03282 222523013587 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 222523013588 Domain of unknown function DUF77; Region: DUF77; pfam01910 222523013589 Cache domain; Region: Cache_1; pfam02743 222523013590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523013591 dimerization interface [polypeptide binding]; other site 222523013592 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523013593 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523013594 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523013595 dimer interface [polypeptide binding]; other site 222523013596 putative CheW interface [polypeptide binding]; other site 222523013597 Predicted transcriptional regulators [Transcription]; Region: COG1378 222523013598 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 222523013599 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 222523013600 C-terminal domain interface [polypeptide binding]; other site 222523013601 sugar binding site [chemical binding]; other site 222523013602 TQXA domain; Region: TQXA_dom; TIGR03934 222523013603 Cna protein B-type domain; Region: Cna_B; pfam05738 222523013604 Cna protein B-type domain; Region: Cna_B; pfam05738 222523013605 Cna protein B-type domain; Region: Cna_B; pfam05738 222523013606 Cna protein B-type domain; Region: Cna_B; pfam05738 222523013607 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 222523013608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523013609 putative substrate translocation pore; other site 222523013610 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 222523013611 Spore germination protein; Region: Spore_permease; cl17796 222523013612 MAEBL; Provisional; Region: PTZ00121 222523013613 OxaA-like protein precursor; Validated; Region: PRK01622 222523013614 Uncharacterized conserved protein [Function unknown]; Region: COG1284 222523013615 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 222523013616 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 222523013617 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 222523013618 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 222523013619 hypothetical protein; Provisional; Region: PRK06758 222523013620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523013621 non-specific DNA binding site [nucleotide binding]; other site 222523013622 salt bridge; other site 222523013623 sequence-specific DNA binding site [nucleotide binding]; other site 222523013624 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 222523013625 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 222523013626 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 222523013627 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 222523013628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 222523013629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523013630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523013631 active site 222523013632 phosphorylation site [posttranslational modification] 222523013633 intermolecular recognition site; other site 222523013634 dimerization interface [polypeptide binding]; other site 222523013635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523013636 DNA binding site [nucleotide binding] 222523013637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 222523013638 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523013639 dimer interface [polypeptide binding]; other site 222523013640 phosphorylation site [posttranslational modification] 222523013641 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523013642 ATP binding site [chemical binding]; other site 222523013643 Mg2+ binding site [ion binding]; other site 222523013644 G-X-G motif; other site 222523013645 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 222523013646 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 222523013647 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 222523013648 active site 222523013649 HIGH motif; other site 222523013650 KMSKS motif; other site 222523013651 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 222523013652 tRNA binding surface [nucleotide binding]; other site 222523013653 anticodon binding site; other site 222523013654 Methyltransferase domain; Region: Methyltransf_23; pfam13489 222523013655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523013656 S-adenosylmethionine binding site [chemical binding]; other site 222523013657 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 222523013658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523013659 dimerization interface [polypeptide binding]; other site 222523013660 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523013661 dimer interface [polypeptide binding]; other site 222523013662 putative CheW interface [polypeptide binding]; other site 222523013663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523013664 dimerization interface [polypeptide binding]; other site 222523013665 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523013666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523013667 dimer interface [polypeptide binding]; other site 222523013668 putative CheW interface [polypeptide binding]; other site 222523013669 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 222523013670 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 222523013671 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 222523013672 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 222523013673 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 222523013674 active site 222523013675 Zn binding site [ion binding]; other site 222523013676 Pirin-related protein [General function prediction only]; Region: COG1741 222523013677 Pirin; Region: Pirin; pfam02678 222523013678 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523013679 MarR family; Region: MarR; pfam01047 222523013680 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 222523013681 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 222523013682 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 222523013683 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 222523013684 TrkA-C domain; Region: TrkA_C; pfam02080 222523013685 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 222523013686 amino acid carrier protein; Region: agcS; TIGR00835 222523013687 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 222523013688 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 222523013689 dimerization interface [polypeptide binding]; other site 222523013690 DPS ferroxidase diiron center [ion binding]; other site 222523013691 ion pore; other site 222523013692 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 222523013693 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 222523013694 metal binding site [ion binding]; metal-binding site 222523013695 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 222523013696 Ferritin-like domain; Region: Ferritin; pfam00210 222523013697 ferroxidase diiron center [ion binding]; other site 222523013698 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523013699 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523013700 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523013701 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523013702 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523013703 Nucleoside recognition; Region: Gate; pfam07670 222523013704 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523013705 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 222523013706 amino acid carrier protein; Region: agcS; TIGR00835 222523013707 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 222523013708 amino acid carrier protein; Region: agcS; TIGR00835 222523013709 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 222523013710 NADH(P)-binding; Region: NAD_binding_10; pfam13460 222523013711 NAD binding site [chemical binding]; other site 222523013712 substrate binding site [chemical binding]; other site 222523013713 putative active site [active] 222523013714 Peptidase M60-like family; Region: M60-like; pfam13402 222523013715 Viral enhancin protein; Region: Enhancin; pfam03272 222523013716 TQXA domain; Region: TQXA_dom; TIGR03934 222523013717 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 222523013718 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 222523013719 active site 222523013720 catalytic tetrad [active] 222523013721 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 222523013722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523013723 putative substrate translocation pore; other site 222523013724 Predicted transcriptional regulators [Transcription]; Region: COG1733 222523013725 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523013726 dimerization interface [polypeptide binding]; other site 222523013727 putative DNA binding site [nucleotide binding]; other site 222523013728 putative Zn2+ binding site [ion binding]; other site 222523013729 Uncharacterized conserved protein [Function unknown]; Region: COG2427 222523013730 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 222523013731 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523013732 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 222523013733 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 222523013734 active site 222523013735 HIGH motif; other site 222523013736 dimer interface [polypeptide binding]; other site 222523013737 KMSKS motif; other site 222523013738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 222523013739 RNA binding surface [nucleotide binding]; other site 222523013740 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 222523013741 FAD binding domain; Region: FAD_binding_4; pfam01565 222523013742 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 222523013743 SET domain; Region: SET; pfam00856 222523013744 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 222523013745 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523013746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523013747 dimer interface [polypeptide binding]; other site 222523013748 putative CheW interface [polypeptide binding]; other site 222523013749 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 222523013750 putative phosphate binding site [ion binding]; other site 222523013751 camphor resistance protein CrcB; Provisional; Region: PRK14219 222523013752 camphor resistance protein CrcB; Provisional; Region: PRK14205 222523013753 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 222523013754 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 222523013755 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 222523013756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523013757 Coenzyme A binding pocket [chemical binding]; other site 222523013758 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 222523013759 Nuclease-related domain; Region: NERD; pfam08378 222523013760 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 222523013761 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 222523013762 Walker A/P-loop; other site 222523013763 ATP binding site [chemical binding]; other site 222523013764 Q-loop/lid; other site 222523013765 ABC transporter signature motif; other site 222523013766 Walker B; other site 222523013767 D-loop; other site 222523013768 H-loop/switch region; other site 222523013769 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523013770 ABC-ATPase subunit interface; other site 222523013771 dimer interface [polypeptide binding]; other site 222523013772 putative PBP binding regions; other site 222523013773 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523013774 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523013775 ABC-ATPase subunit interface; other site 222523013776 dimer interface [polypeptide binding]; other site 222523013777 putative PBP binding regions; other site 222523013778 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 222523013779 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 222523013780 putative ligand binding residues [chemical binding]; other site 222523013781 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523013782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523013783 active site 222523013784 phosphorylation site [posttranslational modification] 222523013785 intermolecular recognition site; other site 222523013786 dimerization interface [polypeptide binding]; other site 222523013787 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523013788 DNA binding site [nucleotide binding] 222523013789 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 222523013790 SmpB-tmRNA interface; other site 222523013791 ribonuclease R; Region: RNase_R; TIGR02063 222523013792 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 222523013793 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 222523013794 RNB domain; Region: RNB; pfam00773 222523013795 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 222523013796 RNA binding site [nucleotide binding]; other site 222523013797 Esterase/lipase [General function prediction only]; Region: COG1647 222523013798 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 222523013799 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 222523013800 holin-like protein; Validated; Region: PRK01658 222523013801 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 222523013802 active site 222523013803 enolase; Provisional; Region: eno; PRK00077 222523013804 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 222523013805 dimer interface [polypeptide binding]; other site 222523013806 metal binding site [ion binding]; metal-binding site 222523013807 substrate binding pocket [chemical binding]; other site 222523013808 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 222523013809 phosphoglyceromutase; Provisional; Region: PRK05434 222523013810 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 222523013811 triosephosphate isomerase; Provisional; Region: PRK14565 222523013812 substrate binding site [chemical binding]; other site 222523013813 dimer interface [polypeptide binding]; other site 222523013814 catalytic triad [active] 222523013815 Phosphoglycerate kinase; Region: PGK; pfam00162 222523013816 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 222523013817 substrate binding site [chemical binding]; other site 222523013818 hinge regions; other site 222523013819 ADP binding site [chemical binding]; other site 222523013820 catalytic site [active] 222523013821 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 222523013822 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 222523013823 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 222523013824 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 222523013825 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 222523013826 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 222523013827 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 222523013828 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 222523013829 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 222523013830 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 222523013831 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 222523013832 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 222523013833 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 222523013834 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 222523013835 stage V sporulation protein AD; Provisional; Region: PRK12404 222523013836 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 222523013837 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 222523013838 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 222523013839 Predicted membrane protein [Function unknown]; Region: COG2323 222523013840 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 222523013841 Clp protease; Region: CLP_protease; pfam00574 222523013842 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 222523013843 oligomer interface [polypeptide binding]; other site 222523013844 active site residues [active] 222523013845 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 222523013846 dimerization domain swap beta strand [polypeptide binding]; other site 222523013847 regulatory protein interface [polypeptide binding]; other site 222523013848 active site 222523013849 regulatory phosphorylation site [posttranslational modification]; other site 222523013850 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 222523013851 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 222523013852 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 222523013853 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 222523013854 phosphate binding site [ion binding]; other site 222523013855 putative substrate binding pocket [chemical binding]; other site 222523013856 dimer interface [polypeptide binding]; other site 222523013857 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 222523013858 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 222523013859 putative active site [active] 222523013860 nucleotide binding site [chemical binding]; other site 222523013861 nudix motif; other site 222523013862 putative metal binding site [ion binding]; other site 222523013863 Domain of unknown function (DUF368); Region: DUF368; pfam04018 222523013864 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 222523013865 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 222523013866 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 222523013867 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523013868 binding surface 222523013869 TPR motif; other site 222523013870 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523013871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523013872 binding surface 222523013873 Tetratricopeptide repeat; Region: TPR_16; pfam13432 222523013874 TPR motif; other site 222523013875 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 222523013876 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 222523013877 trimer interface [polypeptide binding]; other site 222523013878 active site 222523013879 substrate binding site [chemical binding]; other site 222523013880 CoA binding site [chemical binding]; other site 222523013881 pyrophosphatase PpaX; Provisional; Region: PRK13288 222523013882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523013883 active site 222523013884 motif I; other site 222523013885 motif II; other site 222523013886 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 222523013887 HPr kinase/phosphorylase; Provisional; Region: PRK05428 222523013888 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 222523013889 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 222523013890 Hpr binding site; other site 222523013891 active site 222523013892 homohexamer subunit interaction site [polypeptide binding]; other site 222523013893 Predicted membrane protein [Function unknown]; Region: COG1950 222523013894 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 222523013895 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 222523013896 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 222523013897 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 222523013898 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 222523013899 excinuclease ABC subunit B; Provisional; Region: PRK05298 222523013900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523013901 ATP binding site [chemical binding]; other site 222523013902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523013903 nucleotide binding region [chemical binding]; other site 222523013904 ATP-binding site [chemical binding]; other site 222523013905 Ultra-violet resistance protein B; Region: UvrB; pfam12344 222523013906 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 222523013907 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523013908 DNA binding residues [nucleotide binding] 222523013909 dimer interface [polypeptide binding]; other site 222523013910 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 222523013911 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523013912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523013913 non-specific DNA binding site [nucleotide binding]; other site 222523013914 salt bridge; other site 222523013915 sequence-specific DNA binding site [nucleotide binding]; other site 222523013916 Predicted membrane protein [Function unknown]; Region: COG2855 222523013917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523013918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523013919 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 222523013920 putative dimerization interface [polypeptide binding]; other site 222523013921 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 222523013922 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 222523013923 DNA binding residues [nucleotide binding] 222523013924 putative dimer interface [polypeptide binding]; other site 222523013925 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 222523013926 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 222523013927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523013928 D-loop; other site 222523013929 H-loop/switch region; other site 222523013930 hypothetical protein; Provisional; Region: PRK12855 222523013931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 222523013932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 222523013933 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 222523013934 Walker A/P-loop; other site 222523013935 ATP binding site [chemical binding]; other site 222523013936 Q-loop/lid; other site 222523013937 ABC transporter signature motif; other site 222523013938 Walker B; other site 222523013939 D-loop; other site 222523013940 H-loop/switch region; other site 222523013941 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 222523013942 protein binding site [polypeptide binding]; other site 222523013943 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 222523013944 C-terminal peptidase (prc); Region: prc; TIGR00225 222523013945 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 222523013946 protein binding site [polypeptide binding]; other site 222523013947 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 222523013948 Catalytic dyad [active] 222523013949 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 222523013950 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 222523013951 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 222523013952 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 222523013953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523013954 Walker A/P-loop; other site 222523013955 ATP binding site [chemical binding]; other site 222523013956 Q-loop/lid; other site 222523013957 ABC transporter signature motif; other site 222523013958 Walker B; other site 222523013959 D-loop; other site 222523013960 H-loop/switch region; other site 222523013961 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 222523013962 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 222523013963 peptide chain release factor 2; Provisional; Region: PRK06746 222523013964 This domain is found in peptide chain release factors; Region: PCRF; smart00937 222523013965 RF-1 domain; Region: RF-1; pfam00472 222523013966 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 222523013967 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 222523013968 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 222523013969 nucleotide binding region [chemical binding]; other site 222523013970 ATP-binding site [chemical binding]; other site 222523013971 SEC-C motif; Region: SEC-C; pfam02810 222523013972 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 222523013973 30S subunit binding site; other site 222523013974 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 222523013975 DNA-binding site [nucleotide binding]; DNA binding site 222523013976 RNA-binding motif; other site 222523013977 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 222523013978 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523013979 active site 222523013980 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 222523013981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523013982 ATP binding site [chemical binding]; other site 222523013983 putative Mg++ binding site [ion binding]; other site 222523013984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523013985 nucleotide binding region [chemical binding]; other site 222523013986 ATP-binding site [chemical binding]; other site 222523013987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 222523013988 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 222523013989 NlpC/P60 family; Region: NLPC_P60; pfam00877 222523013990 Predicted transcriptional regulators [Transcription]; Region: COG1733 222523013991 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523013992 dimerization interface [polypeptide binding]; other site 222523013993 putative DNA binding site [nucleotide binding]; other site 222523013994 putative Zn2+ binding site [ion binding]; other site 222523013995 EDD domain protein, DegV family; Region: DegV; TIGR00762 222523013996 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 222523013997 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 222523013998 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 222523013999 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 222523014000 Transcriptional regulator [Transcription]; Region: LytR; COG1316 222523014001 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 222523014002 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 222523014003 active site 222523014004 homodimer interface [polypeptide binding]; other site 222523014005 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 222523014006 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 222523014007 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 222523014008 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 222523014009 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 222523014010 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 222523014011 Mg++ binding site [ion binding]; other site 222523014012 putative catalytic motif [active] 222523014013 substrate binding site [chemical binding]; other site 222523014014 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 222523014015 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 222523014016 NodB motif; other site 222523014017 active site 222523014018 catalytic site [active] 222523014019 Zn binding site [ion binding]; other site 222523014020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 222523014021 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 222523014022 Walker A motif; other site 222523014023 ATP binding site [chemical binding]; other site 222523014024 Walker B motif; other site 222523014025 arginine finger; other site 222523014026 Transcriptional antiterminator [Transcription]; Region: COG3933 222523014027 PRD domain; Region: PRD; pfam00874 222523014028 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 222523014029 active pocket/dimerization site; other site 222523014030 active site 222523014031 phosphorylation site [posttranslational modification] 222523014032 PRD domain; Region: PRD; pfam00874 222523014033 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 222523014034 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 222523014035 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 222523014036 Chromate transporter; Region: Chromate_transp; pfam02417 222523014037 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 222523014038 putative active site [active] 222523014039 YdjC motif; other site 222523014040 Mg binding site [ion binding]; other site 222523014041 putative homodimer interface [polypeptide binding]; other site 222523014042 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 222523014043 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 222523014044 NAD binding site [chemical binding]; other site 222523014045 sugar binding site [chemical binding]; other site 222523014046 divalent metal binding site [ion binding]; other site 222523014047 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523014048 dimer interface [polypeptide binding]; other site 222523014049 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 222523014050 active site 222523014051 methionine cluster; other site 222523014052 phosphorylation site [posttranslational modification] 222523014053 metal binding site [ion binding]; metal-binding site 222523014054 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 222523014055 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 222523014056 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 222523014057 active site 222523014058 P-loop; other site 222523014059 phosphorylation site [posttranslational modification] 222523014060 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 222523014061 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523014062 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 222523014063 DNA binding residues [nucleotide binding] 222523014064 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 222523014065 methionine cluster; other site 222523014066 active site 222523014067 phosphorylation site [posttranslational modification] 222523014068 metal binding site [ion binding]; metal-binding site 222523014069 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 222523014070 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 222523014071 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 222523014072 active site 222523014073 P-loop; other site 222523014074 phosphorylation site [posttranslational modification] 222523014075 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 222523014076 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 222523014077 Acyltransferase family; Region: Acyl_transf_3; pfam01757 222523014078 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 222523014079 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 222523014080 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 222523014081 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 222523014082 active site 222523014083 catalytic site [active] 222523014084 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014085 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014086 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 222523014087 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 222523014088 Domain of unknown function DUF11; Region: DUF11; pfam01345 222523014089 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 222523014090 conserved repeat domain; Region: B_ant_repeat; TIGR01451 222523014091 Domain of unknown function DUF11; Region: DUF11; cl17728 222523014092 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014093 Predicted membrane protein [Function unknown]; Region: COG1511 222523014094 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 222523014095 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 222523014096 Transcriptional regulator [Transcription]; Region: LysR; COG0583 222523014097 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 222523014098 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 222523014099 putative dimerization interface [polypeptide binding]; other site 222523014100 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 222523014101 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 222523014102 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 222523014103 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 222523014104 transmembrane helices; other site 222523014105 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 222523014106 ThiC-associated domain; Region: ThiC-associated; pfam13667 222523014107 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 222523014108 L-lactate permease; Region: Lactate_perm; cl00701 222523014109 glycolate transporter; Provisional; Region: PRK09695 222523014110 Tic20-like protein; Region: Tic20; pfam09685 222523014111 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 222523014112 Uncharacterized conserved protein [Function unknown]; Region: COG3339 222523014113 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 222523014114 Sulfatase; Region: Sulfatase; pfam00884 222523014115 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 222523014116 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 222523014117 homodimer interface [polypeptide binding]; other site 222523014118 substrate-cofactor binding pocket; other site 222523014119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523014120 catalytic residue [active] 222523014121 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014122 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014123 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014124 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014125 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014126 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 222523014127 NlpC/P60 family; Region: NLPC_P60; pfam00877 222523014128 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 222523014129 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 222523014130 Nucleoside recognition; Region: Gate; pfam07670 222523014131 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 222523014132 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 222523014133 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 222523014134 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 222523014135 DXD motif; other site 222523014136 BCCT family transporter; Region: BCCT; pfam02028 222523014137 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014138 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523014139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 222523014140 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 222523014141 Predicted membrane protein [Function unknown]; Region: COG4640 222523014142 SNF2 Helicase protein; Region: DUF3670; pfam12419 222523014143 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 222523014144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 222523014145 ATP binding site [chemical binding]; other site 222523014146 putative Mg++ binding site [ion binding]; other site 222523014147 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 222523014148 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523014149 nucleotide binding region [chemical binding]; other site 222523014150 ATP-binding site [chemical binding]; other site 222523014151 Predicted integral membrane protein [Function unknown]; Region: COG5652 222523014152 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 222523014153 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 222523014154 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 222523014155 ComK protein; Region: ComK; pfam06338 222523014156 RNA polymerase factor sigma-70; Validated; Region: PRK06759 222523014157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523014158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523014159 DNA binding residues [nucleotide binding] 222523014160 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 222523014161 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 222523014162 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 222523014163 FtsX-like permease family; Region: FtsX; pfam02687 222523014164 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 222523014165 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 222523014166 Walker A/P-loop; other site 222523014167 ATP binding site [chemical binding]; other site 222523014168 Q-loop/lid; other site 222523014169 ABC transporter signature motif; other site 222523014170 Walker B; other site 222523014171 D-loop; other site 222523014172 H-loop/switch region; other site 222523014173 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 222523014174 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 222523014175 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 222523014176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523014177 putative substrate translocation pore; other site 222523014178 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 222523014179 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 222523014180 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 222523014181 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 222523014182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523014183 dimerization interface [polypeptide binding]; other site 222523014184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523014185 dimer interface [polypeptide binding]; other site 222523014186 phosphorylation site [posttranslational modification] 222523014187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523014188 ATP binding site [chemical binding]; other site 222523014189 Mg2+ binding site [ion binding]; other site 222523014190 G-X-G motif; other site 222523014191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523014192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014193 active site 222523014194 phosphorylation site [posttranslational modification] 222523014195 intermolecular recognition site; other site 222523014196 dimerization interface [polypeptide binding]; other site 222523014197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523014198 DNA binding site [nucleotide binding] 222523014199 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 222523014200 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 222523014201 NAD binding site [chemical binding]; other site 222523014202 homodimer interface [polypeptide binding]; other site 222523014203 active site 222523014204 substrate binding site [chemical binding]; other site 222523014205 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 222523014206 UDP-glucose 4-epimerase; Region: PLN02240 222523014207 NAD binding site [chemical binding]; other site 222523014208 homodimer interface [polypeptide binding]; other site 222523014209 active site 222523014210 substrate binding site [chemical binding]; other site 222523014211 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 222523014212 catalytic triad [active] 222523014213 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 222523014214 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 222523014215 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 222523014216 putative NAD(P) binding site [chemical binding]; other site 222523014217 active site 222523014218 putative substrate binding site [chemical binding]; other site 222523014219 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 222523014220 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 222523014221 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 222523014222 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 222523014223 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 222523014224 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 222523014225 active site 222523014226 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 222523014227 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 222523014228 O-Antigen ligase; Region: Wzy_C; pfam04932 222523014229 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 222523014230 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 222523014231 putative ADP-binding pocket [chemical binding]; other site 222523014232 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 222523014233 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 222523014234 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 222523014235 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 222523014236 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 222523014237 active site 222523014238 Bacterial sugar transferase; Region: Bac_transf; pfam02397 222523014239 aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181 222523014240 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 222523014241 inhibitor-cofactor binding pocket; inhibition site 222523014242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523014243 catalytic residue [active] 222523014244 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 222523014245 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 222523014246 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 222523014247 NAD(P) binding site [chemical binding]; other site 222523014248 homodimer interface [polypeptide binding]; other site 222523014249 substrate binding site [chemical binding]; other site 222523014250 active site 222523014251 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 222523014252 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 222523014253 active site 222523014254 tetramer interface; other site 222523014255 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 222523014256 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 222523014257 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 222523014258 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 222523014259 Chain length determinant protein; Region: Wzz; cl15801 222523014260 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 222523014261 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 222523014262 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 222523014263 rod shape-determining protein Mbl; Provisional; Region: PRK13928 222523014264 MreB and similar proteins; Region: MreB_like; cd10225 222523014265 nucleotide binding site [chemical binding]; other site 222523014266 Mg binding site [ion binding]; other site 222523014267 putative protofilament interaction site [polypeptide binding]; other site 222523014268 RodZ interaction site [polypeptide binding]; other site 222523014269 Stage III sporulation protein D; Region: SpoIIID; pfam12116 222523014270 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523014271 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523014272 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 222523014273 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 222523014274 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523014275 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523014276 Walker A/P-loop; other site 222523014277 ATP binding site [chemical binding]; other site 222523014278 Q-loop/lid; other site 222523014279 ABC transporter signature motif; other site 222523014280 Walker B; other site 222523014281 D-loop; other site 222523014282 H-loop/switch region; other site 222523014283 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 222523014284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 222523014285 Walker A/P-loop; other site 222523014286 ATP binding site [chemical binding]; other site 222523014287 Q-loop/lid; other site 222523014288 ABC transporter signature motif; other site 222523014289 Walker B; other site 222523014290 D-loop; other site 222523014291 H-loop/switch region; other site 222523014292 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 222523014293 LytTr DNA-binding domain; Region: LytTR; pfam04397 222523014294 Stage II sporulation protein; Region: SpoIID; pfam08486 222523014295 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 222523014296 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 222523014297 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 222523014298 hinge; other site 222523014299 active site 222523014300 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 222523014301 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 222523014302 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 222523014303 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 222523014304 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 222523014305 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 222523014306 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 222523014307 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 222523014308 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 222523014309 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 222523014310 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 222523014311 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 222523014312 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 222523014313 4Fe-4S binding domain; Region: Fer4; cl02805 222523014314 4Fe-4S binding domain; Region: Fer4; pfam00037 222523014315 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 222523014316 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 222523014317 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 222523014318 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 222523014319 NADH dehydrogenase subunit C; Validated; Region: PRK07735 222523014320 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 222523014321 NADH dehydrogenase subunit B; Validated; Region: PRK06411 222523014322 NADH dehydrogenase subunit A; Validated; Region: PRK07756 222523014323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523014324 PAS domain; Region: PAS_9; pfam13426 222523014325 putative active site [active] 222523014326 heme pocket [chemical binding]; other site 222523014327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 222523014328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523014329 metal binding site [ion binding]; metal-binding site 222523014330 active site 222523014331 I-site; other site 222523014332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 222523014333 Protein of unknown function (DUF975); Region: DUF975; cl10504 222523014334 Protein of unknown function (DUF975); Region: DUF975; cl10504 222523014335 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 222523014336 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 222523014337 gamma subunit interface [polypeptide binding]; other site 222523014338 epsilon subunit interface [polypeptide binding]; other site 222523014339 LBP interface [polypeptide binding]; other site 222523014340 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 222523014341 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 222523014342 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 222523014343 alpha subunit interaction interface [polypeptide binding]; other site 222523014344 Walker A motif; other site 222523014345 ATP binding site [chemical binding]; other site 222523014346 Walker B motif; other site 222523014347 inhibitor binding site; inhibition site 222523014348 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 222523014349 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 222523014350 core domain interface [polypeptide binding]; other site 222523014351 delta subunit interface [polypeptide binding]; other site 222523014352 epsilon subunit interface [polypeptide binding]; other site 222523014353 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 222523014354 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 222523014355 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 222523014356 beta subunit interaction interface [polypeptide binding]; other site 222523014357 Walker A motif; other site 222523014358 ATP binding site [chemical binding]; other site 222523014359 Walker B motif; other site 222523014360 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 222523014361 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 222523014362 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 222523014363 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 222523014364 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 222523014365 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 222523014366 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 222523014367 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 222523014368 ATP synthase I chain; Region: ATP_synt_I; pfam03899 222523014369 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 222523014370 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 222523014371 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 222523014372 active site 222523014373 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 222523014374 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 222523014375 dimer interface [polypeptide binding]; other site 222523014376 active site 222523014377 glycine-pyridoxal phosphate binding site [chemical binding]; other site 222523014378 folate binding site [chemical binding]; other site 222523014379 hypothetical protein; Provisional; Region: PRK13690 222523014380 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 222523014381 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 222523014382 Low molecular weight phosphatase family; Region: LMWPc; cd00115 222523014383 active site 222523014384 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 222523014385 HPr interaction site; other site 222523014386 glycerol kinase (GK) interaction site [polypeptide binding]; other site 222523014387 active site 222523014388 phosphorylation site [posttranslational modification] 222523014389 Predicted membrane protein [Function unknown]; Region: COG2259 222523014390 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 222523014391 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 222523014392 oligomer interface [polypeptide binding]; other site 222523014393 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 222523014394 Predicted membrane protein [Function unknown]; Region: COG1971 222523014395 Domain of unknown function DUF; Region: DUF204; pfam02659 222523014396 Domain of unknown function DUF; Region: DUF204; pfam02659 222523014397 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 222523014398 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 222523014399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 222523014400 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 222523014401 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 222523014402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523014403 S-adenosylmethionine binding site [chemical binding]; other site 222523014404 peptide chain release factor 1; Validated; Region: prfA; PRK00591 222523014405 This domain is found in peptide chain release factors; Region: PCRF; smart00937 222523014406 RF-1 domain; Region: RF-1; pfam00472 222523014407 thymidine kinase; Provisional; Region: PRK04296 222523014408 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 222523014409 transcription termination factor Rho; Provisional; Region: rho; PRK09376 222523014410 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 222523014411 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 222523014412 RNA binding site [nucleotide binding]; other site 222523014413 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 222523014414 multimer interface [polypeptide binding]; other site 222523014415 Walker A motif; other site 222523014416 ATP binding site [chemical binding]; other site 222523014417 Walker B motif; other site 222523014418 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 222523014419 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 222523014420 putative active site [active] 222523014421 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 222523014422 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 222523014423 hinge; other site 222523014424 active site 222523014425 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 222523014426 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 222523014427 intersubunit interface [polypeptide binding]; other site 222523014428 active site 222523014429 zinc binding site [ion binding]; other site 222523014430 Na+ binding site [ion binding]; other site 222523014431 Response regulator receiver domain; Region: Response_reg; pfam00072 222523014432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014433 active site 222523014434 phosphorylation site [posttranslational modification] 222523014435 intermolecular recognition site; other site 222523014436 dimerization interface [polypeptide binding]; other site 222523014437 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 222523014438 CTP synthetase; Validated; Region: pyrG; PRK05380 222523014439 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 222523014440 Catalytic site [active] 222523014441 active site 222523014442 UTP binding site [chemical binding]; other site 222523014443 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 222523014444 active site 222523014445 putative oxyanion hole; other site 222523014446 catalytic triad [active] 222523014447 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 222523014448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523014449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523014450 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 222523014451 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 222523014452 FAD binding site [chemical binding]; other site 222523014453 homotetramer interface [polypeptide binding]; other site 222523014454 substrate binding pocket [chemical binding]; other site 222523014455 catalytic base [active] 222523014456 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 222523014457 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 222523014458 FAD binding site [chemical binding]; other site 222523014459 homotetramer interface [polypeptide binding]; other site 222523014460 substrate binding pocket [chemical binding]; other site 222523014461 catalytic base [active] 222523014462 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 222523014463 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 222523014464 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 222523014465 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 222523014466 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 222523014467 dimer interface [polypeptide binding]; other site 222523014468 active site 222523014469 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 222523014470 4Fe-4S binding domain; Region: Fer4; cl02805 222523014471 Cysteine-rich domain; Region: CCG; pfam02754 222523014472 Cysteine-rich domain; Region: CCG; pfam02754 222523014473 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 222523014474 PLD-like domain; Region: PLDc_2; pfam13091 222523014475 putative active site [active] 222523014476 catalytic site [active] 222523014477 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 222523014478 PLD-like domain; Region: PLDc_2; pfam13091 222523014479 putative active site [active] 222523014480 catalytic site [active] 222523014481 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 222523014482 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 222523014483 PAS domain S-box; Region: sensory_box; TIGR00229 222523014484 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 222523014485 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523014486 metal binding site [ion binding]; metal-binding site 222523014487 active site 222523014488 I-site; other site 222523014489 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 222523014490 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 222523014491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523014492 non-specific DNA binding site [nucleotide binding]; other site 222523014493 salt bridge; other site 222523014494 sequence-specific DNA binding site [nucleotide binding]; other site 222523014495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523014496 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523014497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014498 active site 222523014499 phosphorylation site [posttranslational modification] 222523014500 intermolecular recognition site; other site 222523014501 dimerization interface [polypeptide binding]; other site 222523014502 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523014503 DNA binding residues [nucleotide binding] 222523014504 dimerization interface [polypeptide binding]; other site 222523014505 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523014506 Histidine kinase; Region: HisKA_3; pfam07730 222523014507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523014508 ATP binding site [chemical binding]; other site 222523014509 Mg2+ binding site [ion binding]; other site 222523014510 G-X-G motif; other site 222523014511 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 222523014512 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 222523014513 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523014514 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 222523014515 Walker A/P-loop; other site 222523014516 ATP binding site [chemical binding]; other site 222523014517 Q-loop/lid; other site 222523014518 ABC transporter signature motif; other site 222523014519 Walker B; other site 222523014520 D-loop; other site 222523014521 H-loop/switch region; other site 222523014522 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 222523014523 active site 222523014524 High molecular weight glutenin subunit; Region: Glutenin_hmw; pfam03157 222523014525 MARCKS family; Region: MARCKS; pfam02063 222523014526 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 222523014527 Collagen binding domain; Region: Collagen_bind; pfam05737 222523014528 Collagen binding domain; Region: Collagen_bind; pfam05737 222523014529 Collagen binding domain; Region: Collagen_bind; pfam05737 222523014530 Collagen binding domain; Region: Collagen_bind; pfam05737 222523014531 Collagen binding domain; Region: Collagen_bind; pfam05737 222523014532 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014533 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014534 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014535 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014536 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014537 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014538 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014539 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 222523014540 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014541 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014542 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014543 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014544 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 222523014545 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014546 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014547 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014548 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014549 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014550 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 222523014551 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014552 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014553 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014554 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014555 Cna protein B-type domain; Region: Cna_B; pfam05738 222523014556 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 222523014557 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 222523014558 PA/protease or protease-like domain interface [polypeptide binding]; other site 222523014559 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 222523014560 Peptidase family M28; Region: Peptidase_M28; pfam04389 222523014561 metal binding site [ion binding]; metal-binding site 222523014562 RNA polymerase sigma factor; Provisional; Region: PRK12522 222523014563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 222523014564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 222523014565 DNA binding residues [nucleotide binding] 222523014566 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 222523014567 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 222523014568 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 222523014569 active site 222523014570 HIGH motif; other site 222523014571 KMSK motif region; other site 222523014572 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 222523014573 tRNA binding surface [nucleotide binding]; other site 222523014574 anticodon binding site; other site 222523014575 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 222523014576 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 222523014577 putative dimer interface [polypeptide binding]; other site 222523014578 catalytic triad [active] 222523014579 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 222523014580 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 222523014581 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 222523014582 agmatinase; Region: agmatinase; TIGR01230 222523014583 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 222523014584 putative active site [active] 222523014585 Mn binding site [ion binding]; other site 222523014586 spermidine synthase; Provisional; Region: PRK00811 222523014587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523014588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523014589 Major Facilitator Superfamily; Region: MFS_1; pfam07690 222523014590 putative substrate translocation pore; other site 222523014591 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 222523014592 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 222523014593 DNA binding residues [nucleotide binding] 222523014594 putative dimer interface [polypeptide binding]; other site 222523014595 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 222523014596 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 222523014597 active site 222523014598 catalytic site [active] 222523014599 metal binding site [ion binding]; metal-binding site 222523014600 dimer interface [polypeptide binding]; other site 222523014601 Transglycosylase; Region: Transgly; pfam00912 222523014602 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 222523014603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 222523014604 YwhD family; Region: YwhD; pfam08741 222523014605 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 222523014606 Peptidase family M50; Region: Peptidase_M50; pfam02163 222523014607 active site 222523014608 putative substrate binding region [chemical binding]; other site 222523014609 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 222523014610 active site 1 [active] 222523014611 dimer interface [polypeptide binding]; other site 222523014612 hexamer interface [polypeptide binding]; other site 222523014613 active site 2 [active] 222523014614 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 222523014615 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 222523014616 Zn2+ binding site [ion binding]; other site 222523014617 Mg2+ binding site [ion binding]; other site 222523014618 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 222523014619 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 222523014620 intersubunit interface [polypeptide binding]; other site 222523014621 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 222523014622 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 222523014623 Walker A/P-loop; other site 222523014624 ATP binding site [chemical binding]; other site 222523014625 Q-loop/lid; other site 222523014626 ABC transporter signature motif; other site 222523014627 Walker B; other site 222523014628 D-loop; other site 222523014629 H-loop/switch region; other site 222523014630 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523014631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523014632 ABC-ATPase subunit interface; other site 222523014633 dimer interface [polypeptide binding]; other site 222523014634 putative PBP binding regions; other site 222523014635 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 222523014636 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 222523014637 ABC-ATPase subunit interface; other site 222523014638 dimer interface [polypeptide binding]; other site 222523014639 putative PBP binding regions; other site 222523014640 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 222523014641 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 222523014642 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 222523014643 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 222523014644 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 222523014645 putative heme peroxidase; Provisional; Region: PRK12276 222523014646 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 222523014647 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 222523014648 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 222523014649 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 222523014650 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 222523014651 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 222523014652 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 222523014653 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 222523014654 TrkA-C domain; Region: TrkA_C; pfam02080 222523014655 putative uracil/xanthine transporter; Provisional; Region: PRK11412 222523014656 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 222523014657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523014658 motif II; other site 222523014659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523014660 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 222523014661 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 222523014662 ligand binding site [chemical binding]; other site 222523014663 active site 222523014664 UGI interface [polypeptide binding]; other site 222523014665 catalytic site [active] 222523014666 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 222523014667 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 222523014668 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 222523014669 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 222523014670 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 222523014671 Walker A/P-loop; other site 222523014672 ATP binding site [chemical binding]; other site 222523014673 Q-loop/lid; other site 222523014674 ABC transporter signature motif; other site 222523014675 Walker B; other site 222523014676 D-loop; other site 222523014677 H-loop/switch region; other site 222523014678 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 222523014679 active site 222523014680 catalytic triad [active] 222523014681 oxyanion hole [active] 222523014682 Transcriptional regulators [Transcription]; Region: PurR; COG1609 222523014683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 222523014684 DNA binding site [nucleotide binding] 222523014685 domain linker motif; other site 222523014686 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 222523014687 putative dimerization interface [polypeptide binding]; other site 222523014688 putative ligand binding site [chemical binding]; other site 222523014689 Predicted membrane protein [Function unknown]; Region: COG2364 222523014690 homoserine dehydrogenase; Provisional; Region: PRK06349 222523014691 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 222523014692 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 222523014693 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 222523014694 Homoserine O-succinyltransferase; Region: HTS; pfam04204 222523014695 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 222523014696 proposed active site lysine [active] 222523014697 conserved cys residue [active] 222523014698 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 222523014699 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 222523014700 homodimer interface [polypeptide binding]; other site 222523014701 substrate-cofactor binding pocket; other site 222523014702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 222523014703 catalytic residue [active] 222523014704 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 222523014705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523014706 active site 222523014707 motif I; other site 222523014708 motif II; other site 222523014709 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 222523014710 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 222523014711 ligand binding site [chemical binding]; other site 222523014712 flexible hinge region; other site 222523014713 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 222523014714 azoreductase; Provisional; Region: PRK13556 222523014715 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 222523014716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014717 active site 222523014718 phosphorylation site [posttranslational modification] 222523014719 intermolecular recognition site; other site 222523014720 dimerization interface [polypeptide binding]; other site 222523014721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 222523014722 DNA binding residues [nucleotide binding] 222523014723 dimerization interface [polypeptide binding]; other site 222523014724 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 222523014725 GAF domain; Region: GAF; pfam01590 222523014726 GAF domain; Region: GAF_3; pfam13492 222523014727 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 222523014728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 222523014729 Histidine kinase; Region: HisKA_3; pfam07730 222523014730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523014731 ATP binding site [chemical binding]; other site 222523014732 Mg2+ binding site [ion binding]; other site 222523014733 G-X-G motif; other site 222523014734 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 222523014735 dimer interface [polypeptide binding]; other site 222523014736 substrate binding site [chemical binding]; other site 222523014737 ATP binding site [chemical binding]; other site 222523014738 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 222523014739 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 222523014740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 222523014741 metal binding site [ion binding]; metal-binding site 222523014742 active site 222523014743 I-site; other site 222523014744 Protein of unknown function (DUF466); Region: DUF466; pfam04328 222523014745 carbon starvation protein A; Provisional; Region: PRK15015 222523014746 Carbon starvation protein CstA; Region: CstA; pfam02554 222523014747 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 222523014748 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 222523014749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014750 active site 222523014751 phosphorylation site [posttranslational modification] 222523014752 intermolecular recognition site; other site 222523014753 dimerization interface [polypeptide binding]; other site 222523014754 LytTr DNA-binding domain; Region: LytTR; pfam04397 222523014755 benzoate transport; Region: 2A0115; TIGR00895 222523014756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523014757 putative substrate translocation pore; other site 222523014758 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 222523014759 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 222523014760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 222523014761 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 222523014762 Predicted membrane protein [Function unknown]; Region: COG2860 222523014763 UPF0126 domain; Region: UPF0126; pfam03458 222523014764 UPF0126 domain; Region: UPF0126; pfam03458 222523014765 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 222523014766 heme-binding site [chemical binding]; other site 222523014767 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 222523014768 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 222523014769 dimer interface [polypeptide binding]; other site 222523014770 putative CheW interface [polypeptide binding]; other site 222523014771 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 222523014772 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 222523014773 Fungal specific transcription factor domain; Region: Fungal_trans; cl04389 222523014774 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 222523014775 active site 222523014776 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523014777 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 222523014778 DXD motif; other site 222523014779 Putative Catalytic site; other site 222523014780 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 222523014781 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 222523014782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 222523014783 active site 222523014784 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 222523014785 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523014786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523014787 ABC transporter; Region: ABC_tran_2; pfam12848 222523014788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 222523014789 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 222523014790 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 222523014791 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 222523014792 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 222523014793 Protein export membrane protein; Region: SecD_SecF; cl14618 222523014794 methionine sulfoxide reductase A; Provisional; Region: PRK14054 222523014795 methionine sulfoxide reductase B; Provisional; Region: PRK00222 222523014796 SelR domain; Region: SelR; pfam01641 222523014797 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 222523014798 antiholin-like protein LrgB; Provisional; Region: PRK04288 222523014799 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 222523014800 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 222523014801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014802 active site 222523014803 phosphorylation site [posttranslational modification] 222523014804 intermolecular recognition site; other site 222523014805 dimerization interface [polypeptide binding]; other site 222523014806 LytTr DNA-binding domain; Region: LytTR; pfam04397 222523014807 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 222523014808 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 222523014809 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 222523014810 Histidine kinase; Region: His_kinase; pfam06580 222523014811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523014812 ATP binding site [chemical binding]; other site 222523014813 Mg2+ binding site [ion binding]; other site 222523014814 G-X-G motif; other site 222523014815 benzoate transport; Region: 2A0115; TIGR00895 222523014816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 222523014817 putative substrate translocation pore; other site 222523014818 BCCT family transporter; Region: BCCT; pfam02028 222523014819 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 222523014820 active site 222523014821 dimer interface [polypeptide binding]; other site 222523014822 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 222523014823 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 222523014824 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 222523014825 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 222523014826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 222523014827 NAD(P) binding site [chemical binding]; other site 222523014828 active site 222523014829 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 222523014830 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 222523014831 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 222523014832 GAF domain; Region: GAF_3; pfam13492 222523014833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523014834 binding surface 222523014835 TPR motif; other site 222523014836 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 222523014837 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 222523014838 NodB motif; other site 222523014839 putative active site [active] 222523014840 putative catalytic site [active] 222523014841 putative Zn binding site [ion binding]; other site 222523014842 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 222523014843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 222523014844 Predicted membrane protein [Function unknown]; Region: COG4267 222523014845 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 222523014846 UDP-glucose 4-epimerase; Region: PLN02240 222523014847 NAD binding site [chemical binding]; other site 222523014848 homodimer interface [polypeptide binding]; other site 222523014849 active site 222523014850 substrate binding site [chemical binding]; other site 222523014851 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 222523014852 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 222523014853 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 222523014854 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 222523014855 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 222523014856 ATP binding site [chemical binding]; other site 222523014857 Mg++ binding site [ion binding]; other site 222523014858 motif III; other site 222523014859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523014860 nucleotide binding region [chemical binding]; other site 222523014861 ATP-binding site [chemical binding]; other site 222523014862 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 222523014863 RNA binding site [nucleotide binding]; other site 222523014864 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 222523014865 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 222523014866 active site 222523014867 oligoendopeptidase F; Region: pepF; TIGR00181 222523014868 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 222523014869 active site 222523014870 Zn binding site [ion binding]; other site 222523014871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523014872 FeS/SAM binding site; other site 222523014873 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 222523014874 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523014875 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 222523014876 catalytic residues [active] 222523014877 catalytic nucleophile [active] 222523014878 Presynaptic Site I dimer interface [polypeptide binding]; other site 222523014879 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 222523014880 Synaptic Flat tetramer interface [polypeptide binding]; other site 222523014881 Synaptic Site I dimer interface [polypeptide binding]; other site 222523014882 DNA binding site [nucleotide binding] 222523014883 Recombinase; Region: Recombinase; pfam07508 222523014884 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 222523014885 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 222523014886 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 222523014887 catalytic residues [active] 222523014888 catalytic nucleophile [active] 222523014889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523014890 non-specific DNA binding site [nucleotide binding]; other site 222523014891 salt bridge; other site 222523014892 sequence-specific DNA binding site [nucleotide binding]; other site 222523014893 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 222523014894 DNA methylase; Region: N6_N4_Mtase; cl17433 222523014895 DNA methylase; Region: N6_N4_Mtase; cl17433 222523014896 Methyltransferase domain; Region: Methyltransf_26; pfam13659 222523014897 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 222523014898 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 222523014899 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 222523014900 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 222523014901 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 222523014902 protein binding site [polypeptide binding]; other site 222523014903 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 222523014904 YycH protein; Region: YycI; pfam09648 222523014905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 222523014906 YycH protein; Region: YycH; pfam07435 222523014907 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 222523014908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 222523014909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523014910 dimerization interface [polypeptide binding]; other site 222523014911 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 222523014912 putative active site [active] 222523014913 heme pocket [chemical binding]; other site 222523014914 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523014915 dimer interface [polypeptide binding]; other site 222523014916 phosphorylation site [posttranslational modification] 222523014917 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523014918 ATP binding site [chemical binding]; other site 222523014919 Mg2+ binding site [ion binding]; other site 222523014920 G-X-G motif; other site 222523014921 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523014922 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523014923 active site 222523014924 phosphorylation site [posttranslational modification] 222523014925 intermolecular recognition site; other site 222523014926 dimerization interface [polypeptide binding]; other site 222523014927 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523014928 DNA binding site [nucleotide binding] 222523014929 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 222523014930 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 222523014931 GDP-binding site [chemical binding]; other site 222523014932 ACT binding site; other site 222523014933 IMP binding site; other site 222523014934 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 222523014935 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 222523014936 Walker A motif; other site 222523014937 ATP binding site [chemical binding]; other site 222523014938 Walker B motif; other site 222523014939 DNA binding loops [nucleotide binding] 222523014940 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 222523014941 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 222523014942 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 222523014943 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 222523014944 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 222523014945 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 222523014946 DHH family; Region: DHH; pfam01368 222523014947 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 222523014948 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 222523014949 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 222523014950 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 222523014951 dimer interface [polypeptide binding]; other site 222523014952 ssDNA binding site [nucleotide binding]; other site 222523014953 tetramer (dimer of dimers) interface [polypeptide binding]; other site 222523014954 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 222523014955 GTP-binding protein YchF; Reviewed; Region: PRK09601 222523014956 YchF GTPase; Region: YchF; cd01900 222523014957 G1 box; other site 222523014958 GTP/Mg2+ binding site [chemical binding]; other site 222523014959 Switch I region; other site 222523014960 G2 box; other site 222523014961 Switch II region; other site 222523014962 G3 box; other site 222523014963 G4 box; other site 222523014964 G5 box; other site 222523014965 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 222523014966 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 222523014967 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 222523014968 Mechanosensitive ion channel; Region: MS_channel; pfam00924 222523014969 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 222523014970 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 222523014971 ParB-like nuclease domain; Region: ParB; smart00470 222523014972 KorB domain; Region: KorB; pfam08535 222523014973 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 222523014974 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 222523014975 P-loop; other site 222523014976 Magnesium ion binding site [ion binding]; other site 222523014977 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 222523014978 Magnesium ion binding site [ion binding]; other site 222523014979 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 222523014980 ParB-like nuclease domain; Region: ParBc; pfam02195 222523014981 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 222523014982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523014983 S-adenosylmethionine binding site [chemical binding]; other site 222523014984 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 222523014985 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 222523014986 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 222523014987 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 222523014988 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 222523014989 trmE is a tRNA modification GTPase; Region: trmE; cd04164 222523014990 G1 box; other site 222523014991 GTP/Mg2+ binding site [chemical binding]; other site 222523014992 Switch I region; other site 222523014993 G2 box; other site 222523014994 Switch II region; other site 222523014995 G3 box; other site 222523014996 G4 box; other site 222523014997 G5 box; other site 222523014998 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 222523014999 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 222523015000 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 222523015001 G-X-X-G motif; other site 222523015002 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 222523015003 RxxxH motif; other site 222523015004 OxaA-like protein precursor; Validated; Region: PRK02944 222523015005 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 222523015006 ribonuclease P; Reviewed; Region: rnpA; PRK00499 222523015007 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 222523015008 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523015009 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523015010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523015011 active site 222523015012 DNA binding site [nucleotide binding] 222523015013 Int/Topo IB signature motif; other site 222523015014 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523015015 active site 222523015016 DNA binding site [nucleotide binding] 222523015017 Int/Topo IB signature motif; other site 222523015018 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 222523015019 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 222523015020 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 222523015021 YolD-like protein; Region: YolD; pfam08863 222523015022 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523015023 catalytic residues [active] 222523015024 Predicted membrane protein [Function unknown]; Region: COG2311 222523015025 Protein of unknown function (DUF418); Region: DUF418; cl12135 222523015026 Protein of unknown function (DUF418); Region: DUF418; pfam04235 222523015027 CAAX protease self-immunity; Region: Abi; pfam02517 222523015028 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 222523015029 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 222523015030 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 222523015031 N-acetyl-D-glucosamine binding site [chemical binding]; other site 222523015032 catalytic residue [active] 222523015033 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523015034 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523015035 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 222523015036 NlpC/P60 family; Region: NLPC_P60; pfam00877 222523015037 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 222523015038 AAA-like domain; Region: AAA_10; pfam12846 222523015039 PrgI family protein; Region: PrgI; pfam12666 222523015040 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 222523015041 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 222523015042 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 222523015043 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523015044 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 222523015045 putative active site [active] 222523015046 putative NTP binding site [chemical binding]; other site 222523015047 putative nucleic acid binding site [nucleotide binding]; other site 222523015048 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 222523015049 active site 222523015050 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 222523015051 oxo-acid-lyase/anthranilate synthase; Region: PLN02889 222523015052 WxL domain surface cell wall-binding; Region: WxL; pfam13731 222523015053 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 222523015054 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 222523015055 WxL domain surface cell wall-binding; Region: WxL; pfam13731 222523015056 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 222523015057 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 222523015058 Walker A motif; other site 222523015059 ATP binding site [chemical binding]; other site 222523015060 Walker B motif; other site 222523015061 AAA domain; Region: AAA_31; pfam13614 222523015062 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 222523015063 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 222523015064 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 222523015065 putative transposase OrfB; Reviewed; Region: PHA02517 222523015066 HTH-like domain; Region: HTH_21; pfam13276 222523015067 Integrase core domain; Region: rve; pfam00665 222523015068 Integrase core domain; Region: rve_2; pfam13333 222523015069 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 222523015070 Helix-turn-helix domain; Region: HTH_28; pfam13518 222523015071 Helix-turn-helix domain; Region: HTH_28; pfam13518 222523015072 S-layer homology domain; Region: SLH; pfam00395 222523015073 S-layer homology domain; Region: SLH; pfam00395 222523015074 S-layer homology domain; Region: SLH; pfam00395 222523015075 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 222523015076 Transposase IS200 like; Region: Y1_Tnp; cl00848 222523015077 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 222523015078 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 222523015079 Probable transposase; Region: OrfB_IS605; pfam01385 222523015080 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 222523015081 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 222523015082 DNA binding residues [nucleotide binding] 222523015083 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 222523015084 Replication-relaxation; Region: Replic_Relax; pfam13814 222523015085 Domain of unknown function (DUF373); Region: DUF373; cl12079 222523015086 AAA-like domain; Region: AAA_10; pfam12846 222523015087 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 222523015088 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 222523015089 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 222523015090 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 222523015091 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 222523015092 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523015093 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 222523015094 putative active site [active] 222523015095 putative NTP binding site [chemical binding]; other site 222523015096 putative nucleic acid binding site [nucleotide binding]; other site 222523015097 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 222523015098 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 222523015099 active site 222523015100 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 222523015101 Rad52/22 family double-strand break repair protein; Region: Rad52_Rad22; cl01936 222523015102 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 222523015103 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523015104 putative active site [active] 222523015105 putative NTP binding site [chemical binding]; other site 222523015106 putative nucleic acid binding site [nucleotide binding]; other site 222523015107 DNA polymerase III subunit beta; Validated; Region: PRK05643 222523015108 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 222523015109 putative DNA binding surface [nucleotide binding]; other site 222523015110 dimer interface [polypeptide binding]; other site 222523015111 beta-clamp/clamp loader binding surface; other site 222523015112 beta-clamp/translesion DNA polymerase binding surface; other site 222523015113 Prokaryotic E2 family D; Region: Prok-E2_D; pfam14460 222523015114 PRTRC system protein A; Region: PRTRC_A; TIGR03735 222523015115 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 222523015116 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 222523015117 ATP binding site [chemical binding]; other site 222523015118 substrate interface [chemical binding]; other site 222523015119 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 222523015120 active site 222523015121 NTP binding site [chemical binding]; other site 222523015122 metal binding triad [ion binding]; metal-binding site 222523015123 antibiotic binding site [chemical binding]; other site 222523015124 HEPN domain; Region: HEPN; pfam05168 222523015125 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 222523015126 Active Sites [active] 222523015127 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 222523015128 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 222523015129 active site 222523015130 catalytic residues [active] 222523015131 DNA binding site [nucleotide binding] 222523015132 Int/Topo IB signature motif; other site 222523015133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523015134 non-specific DNA binding site [nucleotide binding]; other site 222523015135 sequence-specific DNA binding site [nucleotide binding]; other site 222523015136 salt bridge; other site 222523015137 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 222523015138 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 222523015139 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 222523015140 putative active site [active] 222523015141 putative NTP binding site [chemical binding]; other site 222523015142 putative nucleic acid binding site [nucleotide binding]; other site 222523015143 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 222523015144 active site 222523015145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 222523015146 S-adenosylmethionine binding site [chemical binding]; other site 222523015147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 222523015148 ATP binding site [chemical binding]; other site 222523015149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 222523015150 nucleotide binding region [chemical binding]; other site 222523015151 ATP-binding site [chemical binding]; other site 222523015152 Nuclease-related domain; Region: NERD; pfam08378 222523015153 DNA topoisomerase III; Provisional; Region: PRK07726 222523015154 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 222523015155 active site 222523015156 putative interdomain interaction site [polypeptide binding]; other site 222523015157 putative metal-binding site [ion binding]; other site 222523015158 putative nucleotide binding site [chemical binding]; other site 222523015159 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 222523015160 domain I; other site 222523015161 DNA binding groove [nucleotide binding] 222523015162 phosphate binding site [ion binding]; other site 222523015163 domain II; other site 222523015164 domain III; other site 222523015165 nucleotide binding site [chemical binding]; other site 222523015166 catalytic site [active] 222523015167 domain IV; other site 222523015168 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 222523015169 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 222523015170 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 222523015171 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 222523015172 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 222523015173 Staphylococcal nuclease homologues; Region: SNc; smart00318 222523015174 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 222523015175 Catalytic site; other site 222523015176 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 222523015177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523015178 dimerization interface [polypeptide binding]; other site 222523015179 putative DNA binding site [nucleotide binding]; other site 222523015180 putative Zn2+ binding site [ion binding]; other site 222523015181 bacterial Hfq-like; Region: Hfq; cd01716 222523015182 hexamer interface [polypeptide binding]; other site 222523015183 Sm1 motif; other site 222523015184 RNA binding site [nucleotide binding]; other site 222523015185 Sm2 motif; other site 222523015186 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523015187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523015188 TPR motif; other site 222523015189 binding surface 222523015190 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 222523015191 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523015192 active site 222523015193 DNA binding site [nucleotide binding] 222523015194 Int/Topo IB signature motif; other site 222523015195 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 222523015196 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 222523015197 active site 222523015198 catalytic residues [active] 222523015199 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 222523015200 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 222523015201 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 222523015202 P loop; other site 222523015203 Nucleotide binding site [chemical binding]; other site 222523015204 DTAP/Switch II; other site 222523015205 Switch I; other site 222523015206 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 222523015207 P loop; other site 222523015208 Nucleotide binding site [chemical binding]; other site 222523015209 DTAP/Switch II; other site 222523015210 Switch I; other site 222523015211 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 222523015212 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 222523015213 Low molecular weight phosphatase family; Region: LMWPc; cd00115 222523015214 active site 222523015215 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 222523015216 arsenical-resistance protein; Region: acr3; TIGR00832 222523015217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523015218 dimerization interface [polypeptide binding]; other site 222523015219 putative DNA binding site [nucleotide binding]; other site 222523015220 putative Zn2+ binding site [ion binding]; other site 222523015221 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 222523015222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 222523015223 Coenzyme A binding pocket [chemical binding]; other site 222523015224 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 222523015225 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 222523015226 amphipathic channel; other site 222523015227 Asn-Pro-Ala signature motifs; other site 222523015228 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 222523015229 B12 binding site [chemical binding]; other site 222523015230 Radical SAM superfamily; Region: Radical_SAM; pfam04055 222523015231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 222523015232 FeS/SAM binding site; other site 222523015233 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523015234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523015235 non-specific DNA binding site [nucleotide binding]; other site 222523015236 salt bridge; other site 222523015237 sequence-specific DNA binding site [nucleotide binding]; other site 222523015238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523015239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 222523015240 TPR motif; other site 222523015241 binding surface 222523015242 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523015243 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523015244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 222523015245 Phosphate transporter family; Region: PHO4; pfam01384 222523015246 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523015247 dimerization interface [polypeptide binding]; other site 222523015248 putative Zn2+ binding site [ion binding]; other site 222523015249 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 222523015250 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 222523015251 MarR family; Region: MarR_2; pfam12802 222523015252 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 222523015253 Predicted permeases [General function prediction only]; Region: COG0701 222523015254 AAA ATPase domain; Region: AAA_16; pfam13191 222523015255 AAA domain; Region: AAA_22; pfam13401 222523015256 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 222523015257 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 222523015258 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523015259 metal-binding site [ion binding] 222523015260 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523015261 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523015262 metal-binding site [ion binding] 222523015263 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 222523015264 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 222523015265 metal-binding site [ion binding] 222523015266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 222523015267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 222523015268 motif II; other site 222523015269 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 222523015270 putative homodimer interface [polypeptide binding]; other site 222523015271 putative homotetramer interface [polypeptide binding]; other site 222523015272 putative allosteric switch controlling residues; other site 222523015273 putative metal binding site [ion binding]; other site 222523015274 putative homodimer-homodimer interface [polypeptide binding]; other site 222523015275 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 222523015276 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 222523015277 metal binding site [ion binding]; metal-binding site 222523015278 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 222523015279 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 222523015280 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 222523015281 catalytic residues [active] 222523015282 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 222523015283 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 222523015284 dimerization interface [polypeptide binding]; other site 222523015285 VPS10 domain; Region: VPS10; smart00602 222523015286 Family description; Region: DsbD_2; pfam13386 222523015287 Predicted metal-binding integral membrane protein [Function unknown]; Region: COG5486 222523015288 Predicted metal-binding integral membrane protein (DUF2182); Region: DUF2182; pfam09948 222523015289 Protein of unknown function (DUF1326); Region: DUF1326; pfam07040 222523015290 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523015291 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523015292 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523015293 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 222523015294 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523015295 Bacterial SH3 domain; Region: SH3_3; pfam08239 222523015296 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 222523015297 Peptidase family M23; Region: Peptidase_M23; pfam01551 222523015298 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 222523015299 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 222523015300 catalytic residues [active] 222523015301 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 222523015302 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 222523015303 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 222523015304 substrate binding pocket [chemical binding]; other site 222523015305 membrane-bound complex binding site; other site 222523015306 hinge residues; other site 222523015307 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 222523015308 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 222523015309 dimer interface [polypeptide binding]; other site 222523015310 conserved gate region; other site 222523015311 putative PBP binding loops; other site 222523015312 ABC-ATPase subunit interface; other site 222523015313 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 222523015314 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 222523015315 Walker A/P-loop; other site 222523015316 ATP binding site [chemical binding]; other site 222523015317 Q-loop/lid; other site 222523015318 ABC transporter signature motif; other site 222523015319 Walker B; other site 222523015320 D-loop; other site 222523015321 H-loop/switch region; other site 222523015322 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 222523015323 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 222523015324 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 222523015325 Copper resistance protein B precursor (CopB); Region: CopB; cl01476 222523015326 Multicopper oxidase; Region: Cu-oxidase; pfam00394 222523015327 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 222523015328 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 222523015329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 222523015330 active site 222523015331 phosphorylation site [posttranslational modification] 222523015332 intermolecular recognition site; other site 222523015333 dimerization interface [polypeptide binding]; other site 222523015334 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 222523015335 DNA binding site [nucleotide binding] 222523015336 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 222523015337 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 222523015338 dimerization interface [polypeptide binding]; other site 222523015339 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 222523015340 dimer interface [polypeptide binding]; other site 222523015341 phosphorylation site [posttranslational modification] 222523015342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 222523015343 ATP binding site [chemical binding]; other site 222523015344 Mg2+ binding site [ion binding]; other site 222523015345 G-X-G motif; other site 222523015346 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 222523015347 stage II sporulation protein P; Region: spore_II_P; TIGR02867 222523015348 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 222523015349 dimerization interface [polypeptide binding]; other site 222523015350 putative DNA binding site [nucleotide binding]; other site 222523015351 putative Zn2+ binding site [ion binding]; other site 222523015352 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 222523015353 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 222523015354 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 222523015355 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 222523015356 Helix-turn-helix domain; Region: HTH_17; pfam12728 222523015357 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 222523015358 active site 222523015359 Int/Topo IB signature motif; other site 222523015360 DNA binding site [nucleotide binding] 222523015361 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 222523015362 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 222523015363 non-specific DNA binding site [nucleotide binding]; other site 222523015364 salt bridge; other site 222523015365 sequence-specific DNA binding site [nucleotide binding]; other site 222523015366 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 222523015367 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 222523015368 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 222523015369 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 222523015370 active site 222523015371 DNA polymerase IV; Reviewed; Region: PRK03103 222523015372 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 222523015373 active site 222523015374 DNA binding site [nucleotide binding] 222523015375 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438