-- dump date 20140618_214703 -- class Genbank::misc_feature -- table misc_feature_note -- id note 288681000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 288681000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000004 Walker A motif; other site 288681000005 ATP binding site [chemical binding]; other site 288681000006 Walker B motif; other site 288681000007 arginine finger; other site 288681000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 288681000009 DnaA box-binding interface [nucleotide binding]; other site 288681000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 288681000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 288681000012 putative DNA binding surface [nucleotide binding]; other site 288681000013 dimer interface [polypeptide binding]; other site 288681000014 beta-clamp/clamp loader binding surface; other site 288681000015 beta-clamp/translesion DNA polymerase binding surface; other site 288681000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 288681000017 recombination protein F; Reviewed; Region: recF; PRK00064 288681000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 288681000019 Walker A/P-loop; other site 288681000020 ATP binding site [chemical binding]; other site 288681000021 Q-loop/lid; other site 288681000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681000023 ABC transporter signature motif; other site 288681000024 Walker B; other site 288681000025 D-loop; other site 288681000026 H-loop/switch region; other site 288681000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 288681000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681000029 Mg2+ binding site [ion binding]; other site 288681000030 G-X-G motif; other site 288681000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 288681000032 anchoring element; other site 288681000033 dimer interface [polypeptide binding]; other site 288681000034 ATP binding site [chemical binding]; other site 288681000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 288681000036 active site 288681000037 putative metal-binding site [ion binding]; other site 288681000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 288681000039 DNA gyrase subunit A; Validated; Region: PRK05560 288681000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 288681000041 CAP-like domain; other site 288681000042 active site 288681000043 primary dimer interface [polypeptide binding]; other site 288681000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681000050 YaaC-like Protein; Region: YaaC; pfam14175 288681000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 288681000052 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 288681000053 active site 288681000054 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681000055 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681000056 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 288681000057 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 288681000058 active site 288681000059 multimer interface [polypeptide binding]; other site 288681000060 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 288681000061 predicted active site [active] 288681000062 catalytic triad [active] 288681000063 seryl-tRNA synthetase; Provisional; Region: PRK05431 288681000064 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 288681000065 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 288681000066 dimer interface [polypeptide binding]; other site 288681000067 active site 288681000068 motif 1; other site 288681000069 motif 2; other site 288681000070 motif 3; other site 288681000071 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 288681000072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681000073 DNA binding residues [nucleotide binding] 288681000074 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 288681000075 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 288681000076 Substrate-binding site [chemical binding]; other site 288681000077 Substrate specificity [chemical binding]; other site 288681000078 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 288681000079 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 288681000080 Substrate-binding site [chemical binding]; other site 288681000081 Substrate specificity [chemical binding]; other site 288681000082 Isochorismatase family; Region: Isochorismatase; pfam00857 288681000083 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 288681000084 catalytic triad [active] 288681000085 conserved cis-peptide bond; other site 288681000086 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 288681000087 nucleoside/Zn binding site; other site 288681000088 dimer interface [polypeptide binding]; other site 288681000089 catalytic motif [active] 288681000090 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 288681000091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000092 Walker A motif; other site 288681000093 ATP binding site [chemical binding]; other site 288681000094 Walker B motif; other site 288681000095 arginine finger; other site 288681000096 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 288681000097 hypothetical protein; Validated; Region: PRK00153 288681000098 recombination protein RecR; Reviewed; Region: recR; PRK00076 288681000099 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 288681000100 RecR protein; Region: RecR; pfam02132 288681000101 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 288681000102 putative active site [active] 288681000103 putative metal-binding site [ion binding]; other site 288681000104 tetramer interface [polypeptide binding]; other site 288681000105 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 288681000106 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 288681000107 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 288681000108 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 288681000109 homodimer interface [polypeptide binding]; other site 288681000110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681000111 catalytic residue [active] 288681000112 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 288681000113 thymidylate kinase; Validated; Region: tmk; PRK00698 288681000114 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 288681000115 TMP-binding site; other site 288681000116 ATP-binding site [chemical binding]; other site 288681000117 DNA polymerase III subunit delta'; Validated; Region: PRK08058 288681000118 DNA polymerase III subunit delta'; Validated; Region: PRK08485 288681000119 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 288681000120 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 288681000121 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 288681000122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681000123 S-adenosylmethionine binding site [chemical binding]; other site 288681000124 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 288681000125 GIY-YIG motif/motif A; other site 288681000126 putative active site [active] 288681000127 putative metal binding site [ion binding]; other site 288681000128 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 288681000129 putative SAM binding site [chemical binding]; other site 288681000130 putative homodimer interface [polypeptide binding]; other site 288681000131 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681000132 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 288681000133 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 288681000134 active site 288681000135 HIGH motif; other site 288681000136 KMSKS motif; other site 288681000137 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 288681000138 tRNA binding surface [nucleotide binding]; other site 288681000139 anticodon binding site; other site 288681000140 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 288681000141 dimer interface [polypeptide binding]; other site 288681000142 putative tRNA-binding site [nucleotide binding]; other site 288681000143 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 288681000144 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 288681000145 active site 288681000146 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 288681000147 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 288681000148 putative active site [active] 288681000149 putative metal binding site [ion binding]; other site 288681000150 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 288681000151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681000152 S-adenosylmethionine binding site [chemical binding]; other site 288681000153 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 288681000154 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 288681000155 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 288681000156 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 288681000157 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288681000158 pur operon repressor; Provisional; Region: PRK09213 288681000159 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 288681000160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000161 active site 288681000162 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 288681000163 homotrimer interaction site [polypeptide binding]; other site 288681000164 putative active site [active] 288681000165 regulatory protein SpoVG; Reviewed; Region: PRK13259 288681000166 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 288681000167 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 288681000168 Substrate binding site; other site 288681000169 Mg++ binding site; other site 288681000170 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 288681000171 active site 288681000172 substrate binding site [chemical binding]; other site 288681000173 CoA binding site [chemical binding]; other site 288681000174 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 288681000175 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 288681000176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000177 active site 288681000178 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 288681000179 putative active site [active] 288681000180 catalytic residue [active] 288681000181 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 288681000182 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 288681000183 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 288681000184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681000185 ATP binding site [chemical binding]; other site 288681000186 putative Mg++ binding site [ion binding]; other site 288681000187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681000188 nucleotide binding region [chemical binding]; other site 288681000189 ATP-binding site [chemical binding]; other site 288681000190 TRCF domain; Region: TRCF; pfam03461 288681000191 stage V sporulation protein T; Region: spore_V_T; TIGR02851 288681000192 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 288681000193 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 288681000194 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 288681000195 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 288681000196 putative SAM binding site [chemical binding]; other site 288681000197 putative homodimer interface [polypeptide binding]; other site 288681000198 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 288681000199 homodimer interface [polypeptide binding]; other site 288681000200 metal binding site [ion binding]; metal-binding site 288681000201 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 288681000202 homodimer interface [polypeptide binding]; other site 288681000203 active site 288681000204 putative chemical substrate binding site [chemical binding]; other site 288681000205 metal binding site [ion binding]; metal-binding site 288681000206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681000207 RNA binding surface [nucleotide binding]; other site 288681000208 sporulation protein YabP; Region: spore_yabP; TIGR02892 288681000209 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 288681000210 Septum formation initiator; Region: DivIC; pfam04977 288681000211 hypothetical protein; Provisional; Region: PRK08582 288681000212 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 288681000213 RNA binding site [nucleotide binding]; other site 288681000214 stage II sporulation protein E; Region: spore_II_E; TIGR02865 288681000215 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 288681000216 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 288681000217 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 288681000218 Ligand Binding Site [chemical binding]; other site 288681000219 TilS substrate binding domain; Region: TilS; pfam09179 288681000220 TilS substrate C-terminal domain; Region: TilS_C; smart00977 288681000221 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000222 active site 288681000223 FtsH Extracellular; Region: FtsH_ext; pfam06480 288681000224 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 288681000225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000226 Walker A motif; other site 288681000227 ATP binding site [chemical binding]; other site 288681000228 Walker B motif; other site 288681000229 arginine finger; other site 288681000230 Peptidase family M41; Region: Peptidase_M41; pfam01434 288681000231 pantothenate kinase; Reviewed; Region: PRK13318 288681000232 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 288681000233 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 288681000234 dimerization interface [polypeptide binding]; other site 288681000235 domain crossover interface; other site 288681000236 redox-dependent activation switch; other site 288681000237 cysteine synthase; Region: PLN02565 288681000238 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288681000239 dimer interface [polypeptide binding]; other site 288681000240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681000241 catalytic residue [active] 288681000242 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 288681000243 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 288681000244 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 288681000245 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 288681000246 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 288681000247 glutamine binding [chemical binding]; other site 288681000248 catalytic triad [active] 288681000249 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 288681000250 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 288681000251 homodimer interface [polypeptide binding]; other site 288681000252 substrate-cofactor binding pocket; other site 288681000253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681000254 catalytic residue [active] 288681000255 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 288681000256 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 288681000257 substrate binding pocket [chemical binding]; other site 288681000258 dimer interface [polypeptide binding]; other site 288681000259 inhibitor binding site; inhibition site 288681000260 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 288681000261 homooctamer interface [polypeptide binding]; other site 288681000262 active site 288681000263 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 288681000264 catalytic center binding site [active] 288681000265 ATP binding site [chemical binding]; other site 288681000266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681000267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681000268 non-specific DNA binding site [nucleotide binding]; other site 288681000269 salt bridge; other site 288681000270 sequence-specific DNA binding site [nucleotide binding]; other site 288681000271 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 288681000272 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 288681000273 FMN binding site [chemical binding]; other site 288681000274 active site 288681000275 catalytic residues [active] 288681000276 substrate binding site [chemical binding]; other site 288681000277 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 288681000278 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 288681000279 dimer interface [polypeptide binding]; other site 288681000280 putative anticodon binding site; other site 288681000281 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 288681000282 motif 1; other site 288681000283 active site 288681000284 motif 2; other site 288681000285 motif 3; other site 288681000286 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 288681000287 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 288681000288 UvrB/uvrC motif; Region: UVR; pfam02151 288681000289 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 288681000290 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 288681000291 ADP binding site [chemical binding]; other site 288681000292 phosphagen binding site; other site 288681000293 substrate specificity loop; other site 288681000294 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 288681000295 Clp amino terminal domain; Region: Clp_N; pfam02861 288681000296 Clp amino terminal domain; Region: Clp_N; pfam02861 288681000297 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000298 Walker A motif; other site 288681000299 ATP binding site [chemical binding]; other site 288681000300 Walker B motif; other site 288681000301 arginine finger; other site 288681000302 UvrB/uvrC motif; Region: UVR; pfam02151 288681000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681000304 Walker A motif; other site 288681000305 ATP binding site [chemical binding]; other site 288681000306 Walker B motif; other site 288681000307 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 288681000308 DNA repair protein RadA; Provisional; Region: PRK11823 288681000309 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 288681000310 Walker A motif/ATP binding site; other site 288681000311 ATP binding site [chemical binding]; other site 288681000312 Walker B motif; other site 288681000313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 288681000314 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 288681000315 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288681000316 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 288681000317 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 288681000318 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 288681000319 putative active site [active] 288681000320 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 288681000321 substrate binding site; other site 288681000322 dimer interface; other site 288681000323 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 288681000324 homotrimer interaction site [polypeptide binding]; other site 288681000325 zinc binding site [ion binding]; other site 288681000326 CDP-binding sites; other site 288681000327 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 288681000328 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 288681000329 active site 288681000330 HIGH motif; other site 288681000331 KMSKS motif; other site 288681000332 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 288681000333 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 288681000334 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 288681000335 trimer interface [polypeptide binding]; other site 288681000336 active site 288681000337 substrate binding site [chemical binding]; other site 288681000338 CoA binding site [chemical binding]; other site 288681000339 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 288681000340 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 288681000341 active site 288681000342 HIGH motif; other site 288681000343 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 288681000344 KMSKS motif; other site 288681000345 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 288681000346 tRNA binding surface [nucleotide binding]; other site 288681000347 anticodon binding site; other site 288681000348 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 288681000349 active site 288681000350 metal binding site [ion binding]; metal-binding site 288681000351 dimerization interface [polypeptide binding]; other site 288681000352 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 288681000353 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 288681000354 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 288681000355 YacP-like NYN domain; Region: NYN_YacP; pfam05991 288681000356 RNA polymerase factor sigma-70; Validated; Region: PRK08295 288681000357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681000358 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 288681000359 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 288681000360 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 288681000361 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 288681000362 putative homodimer interface [polypeptide binding]; other site 288681000363 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 288681000364 heterodimer interface [polypeptide binding]; other site 288681000365 homodimer interface [polypeptide binding]; other site 288681000366 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 288681000367 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 288681000368 23S rRNA interface [nucleotide binding]; other site 288681000369 L7/L12 interface [polypeptide binding]; other site 288681000370 putative thiostrepton binding site; other site 288681000371 L25 interface [polypeptide binding]; other site 288681000372 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 288681000373 mRNA/rRNA interface [nucleotide binding]; other site 288681000374 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 288681000375 23S rRNA interface [nucleotide binding]; other site 288681000376 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 288681000377 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 288681000378 core dimer interface [polypeptide binding]; other site 288681000379 peripheral dimer interface [polypeptide binding]; other site 288681000380 L10 interface [polypeptide binding]; other site 288681000381 L11 interface [polypeptide binding]; other site 288681000382 putative EF-Tu interaction site [polypeptide binding]; other site 288681000383 putative EF-G interaction site [polypeptide binding]; other site 288681000384 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 288681000385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681000386 S-adenosylmethionine binding site [chemical binding]; other site 288681000387 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 288681000388 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 288681000389 RPB12 interaction site [polypeptide binding]; other site 288681000390 RPB1 interaction site [polypeptide binding]; other site 288681000391 RPB10 interaction site [polypeptide binding]; other site 288681000392 RPB11 interaction site [polypeptide binding]; other site 288681000393 RPB3 interaction site [polypeptide binding]; other site 288681000394 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 288681000395 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 288681000396 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 288681000397 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 288681000398 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 288681000399 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 288681000400 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 288681000401 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 288681000402 G-loop; other site 288681000403 DNA binding site [nucleotide binding] 288681000404 hypothetical protein; Provisional; Region: PRK06683 288681000405 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 288681000406 S17 interaction site [polypeptide binding]; other site 288681000407 S8 interaction site; other site 288681000408 16S rRNA interaction site [nucleotide binding]; other site 288681000409 streptomycin interaction site [chemical binding]; other site 288681000410 23S rRNA interaction site [nucleotide binding]; other site 288681000411 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 288681000412 30S ribosomal protein S7; Validated; Region: PRK05302 288681000413 elongation factor G; Reviewed; Region: PRK00007 288681000414 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 288681000415 G1 box; other site 288681000416 putative GEF interaction site [polypeptide binding]; other site 288681000417 GTP/Mg2+ binding site [chemical binding]; other site 288681000418 Switch I region; other site 288681000419 G2 box; other site 288681000420 G3 box; other site 288681000421 Switch II region; other site 288681000422 G4 box; other site 288681000423 G5 box; other site 288681000424 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 288681000425 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 288681000426 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 288681000427 elongation factor Tu; Reviewed; Region: PRK00049 288681000428 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 288681000429 G1 box; other site 288681000430 GEF interaction site [polypeptide binding]; other site 288681000431 GTP/Mg2+ binding site [chemical binding]; other site 288681000432 Switch I region; other site 288681000433 G2 box; other site 288681000434 G3 box; other site 288681000435 Switch II region; other site 288681000436 G4 box; other site 288681000437 G5 box; other site 288681000438 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 288681000439 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 288681000440 Antibiotic Binding Site [chemical binding]; other site 288681000441 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 288681000442 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 288681000443 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 288681000444 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 288681000445 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 288681000446 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 288681000447 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 288681000448 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 288681000449 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 288681000450 putative translocon binding site; other site 288681000451 protein-rRNA interface [nucleotide binding]; other site 288681000452 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 288681000453 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 288681000454 G-X-X-G motif; other site 288681000455 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 288681000456 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 288681000457 23S rRNA interface [nucleotide binding]; other site 288681000458 5S rRNA interface [nucleotide binding]; other site 288681000459 putative antibiotic binding site [chemical binding]; other site 288681000460 L25 interface [polypeptide binding]; other site 288681000461 L27 interface [polypeptide binding]; other site 288681000462 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 288681000463 23S rRNA interface [nucleotide binding]; other site 288681000464 putative translocon interaction site; other site 288681000465 signal recognition particle (SRP54) interaction site; other site 288681000466 L23 interface [polypeptide binding]; other site 288681000467 trigger factor interaction site; other site 288681000468 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 288681000469 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 288681000470 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 288681000471 RNA binding site [nucleotide binding]; other site 288681000472 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 288681000473 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 288681000474 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 288681000475 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 288681000476 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 288681000477 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 288681000478 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 288681000479 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 288681000480 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 288681000481 5S rRNA interface [nucleotide binding]; other site 288681000482 L27 interface [polypeptide binding]; other site 288681000483 23S rRNA interface [nucleotide binding]; other site 288681000484 L5 interface [polypeptide binding]; other site 288681000485 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 288681000486 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 288681000487 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 288681000488 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 288681000489 23S rRNA binding site [nucleotide binding]; other site 288681000490 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 288681000491 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 288681000492 SecY translocase; Region: SecY; pfam00344 288681000493 adenylate kinase; Reviewed; Region: adk; PRK00279 288681000494 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 288681000495 AMP-binding site [chemical binding]; other site 288681000496 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 288681000497 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288681000498 active site 288681000499 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 288681000500 rRNA binding site [nucleotide binding]; other site 288681000501 predicted 30S ribosome binding site; other site 288681000502 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 288681000503 30S ribosomal protein S11; Validated; Region: PRK05309 288681000504 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 288681000505 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 288681000506 alphaNTD - beta interaction site [polypeptide binding]; other site 288681000507 alphaNTD homodimer interface [polypeptide binding]; other site 288681000508 alphaNTD - beta' interaction site [polypeptide binding]; other site 288681000509 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 288681000510 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 288681000511 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 288681000512 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288681000513 Walker A/P-loop; other site 288681000514 ATP binding site [chemical binding]; other site 288681000515 Q-loop/lid; other site 288681000516 ABC transporter signature motif; other site 288681000517 Walker B; other site 288681000518 D-loop; other site 288681000519 H-loop/switch region; other site 288681000520 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 288681000521 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288681000522 Walker A/P-loop; other site 288681000523 ATP binding site [chemical binding]; other site 288681000524 Q-loop/lid; other site 288681000525 ABC transporter signature motif; other site 288681000526 Walker B; other site 288681000527 D-loop; other site 288681000528 H-loop/switch region; other site 288681000529 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 288681000530 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 288681000531 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 288681000532 dimerization interface 3.5A [polypeptide binding]; other site 288681000533 active site 288681000534 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 288681000535 23S rRNA interface [nucleotide binding]; other site 288681000536 L3 interface [polypeptide binding]; other site 288681000537 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 288681000538 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 288681000539 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 288681000540 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681000541 active site 288681000542 metal binding site [ion binding]; metal-binding site 288681000543 Domain of unknown function DUF59; Region: DUF59; pfam01883 288681000544 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 288681000545 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 288681000546 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 288681000547 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681000548 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 288681000549 NodB motif; other site 288681000550 putative active site [active] 288681000551 putative catalytic site [active] 288681000552 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 288681000553 Arginase family; Region: Arginase; cd09989 288681000554 agmatinase; Region: agmatinase; TIGR01230 288681000555 active site 288681000556 Mn binding site [ion binding]; other site 288681000557 oligomer interface [polypeptide binding]; other site 288681000558 Uncharacterized conserved protein [Function unknown]; Region: COG1624 288681000559 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288681000560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 288681000561 YbbR-like protein; Region: YbbR; pfam07949 288681000562 YbbR-like protein; Region: YbbR; pfam07949 288681000563 YbbR-like protein; Region: YbbR; pfam07949 288681000564 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 288681000565 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 288681000566 active site 288681000567 substrate binding site [chemical binding]; other site 288681000568 metal binding site [ion binding]; metal-binding site 288681000569 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 288681000570 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 288681000571 glutaminase active site [active] 288681000572 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 288681000573 dimer interface [polypeptide binding]; other site 288681000574 active site 288681000575 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 288681000576 dimer interface [polypeptide binding]; other site 288681000577 active site 288681000578 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681000579 Transcriptional regulators [Transcription]; Region: GntR; COG1802 288681000580 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681000581 DNA-binding site [nucleotide binding]; DNA binding site 288681000582 FCD domain; Region: FCD; pfam07729 288681000583 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 288681000584 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 288681000585 N- and C-terminal domain interface [polypeptide binding]; other site 288681000586 active site 288681000587 catalytic site [active] 288681000588 metal binding site [ion binding]; metal-binding site 288681000589 carbohydrate binding site [chemical binding]; other site 288681000590 ATP binding site [chemical binding]; other site 288681000591 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288681000592 gluconate transporter; Region: gntP; TIGR00791 288681000593 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288681000594 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 288681000595 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 288681000596 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 288681000597 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288681000598 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 288681000599 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 288681000600 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 288681000601 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 288681000602 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681000603 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681000604 DNA binding residues [nucleotide binding] 288681000605 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 288681000606 classical (c) SDRs; Region: SDR_c; cd05233 288681000607 NAD(P) binding site [chemical binding]; other site 288681000608 active site 288681000609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000610 ABC-ATPase subunit interface; other site 288681000611 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 288681000612 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 288681000613 Walker A/P-loop; other site 288681000614 ATP binding site [chemical binding]; other site 288681000615 Q-loop/lid; other site 288681000616 ABC transporter signature motif; other site 288681000617 Walker B; other site 288681000618 D-loop; other site 288681000619 H-loop/switch region; other site 288681000620 NIL domain; Region: NIL; pfam09383 288681000621 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 288681000622 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681000623 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 288681000624 putative NAD(P) binding site [chemical binding]; other site 288681000625 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 288681000626 FAD binding domain; Region: FAD_binding_4; pfam01565 288681000627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681000628 putative substrate translocation pore; other site 288681000629 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 288681000630 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 288681000631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681000632 putative substrate translocation pore; other site 288681000633 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 288681000634 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 288681000635 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000637 dimer interface [polypeptide binding]; other site 288681000638 conserved gate region; other site 288681000639 putative PBP binding loops; other site 288681000640 ABC-ATPase subunit interface; other site 288681000641 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681000642 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681000643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000644 putative PBP binding loops; other site 288681000645 dimer interface [polypeptide binding]; other site 288681000646 ABC-ATPase subunit interface; other site 288681000647 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681000648 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681000649 Walker A/P-loop; other site 288681000650 ATP binding site [chemical binding]; other site 288681000651 Q-loop/lid; other site 288681000652 ABC transporter signature motif; other site 288681000653 Walker B; other site 288681000654 D-loop; other site 288681000655 H-loop/switch region; other site 288681000656 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681000657 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288681000658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681000659 Walker A/P-loop; other site 288681000660 ATP binding site [chemical binding]; other site 288681000661 Q-loop/lid; other site 288681000662 ABC transporter signature motif; other site 288681000663 Walker B; other site 288681000664 D-loop; other site 288681000665 H-loop/switch region; other site 288681000666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 288681000667 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681000668 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681000669 peptide binding site [polypeptide binding]; other site 288681000670 YusW-like protein; Region: YusW; pfam14039 288681000671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681000672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681000673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681000674 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681000675 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681000676 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681000677 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681000678 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681000679 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681000680 peptide binding site [polypeptide binding]; other site 288681000681 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681000682 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681000683 peptide binding site [polypeptide binding]; other site 288681000684 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681000685 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681000686 active site 288681000687 catalytic tetrad [active] 288681000688 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 288681000689 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 288681000690 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 288681000691 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 288681000692 Sugar transport protein; Region: Sugar_transport; pfam06800 288681000693 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 288681000694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000695 dimer interface [polypeptide binding]; other site 288681000696 conserved gate region; other site 288681000697 putative PBP binding loops; other site 288681000698 ABC-ATPase subunit interface; other site 288681000699 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 288681000700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 288681000701 dimerization interface [polypeptide binding]; other site 288681000702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681000703 membrane-bound complex binding site; other site 288681000704 hinge residues; other site 288681000705 DNA binding domain, excisionase family; Region: excise; TIGR01764 288681000706 PBP superfamily domain; Region: PBP_like; pfam12727 288681000707 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681000708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681000709 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 288681000710 putative dimerization interface [polypeptide binding]; other site 288681000711 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681000712 EamA-like transporter family; Region: EamA; pfam00892 288681000713 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288681000714 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288681000715 putative acyl-acceptor binding pocket; other site 288681000716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681000717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681000718 DNA binding site [nucleotide binding] 288681000719 domain linker motif; other site 288681000720 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681000721 putative ligand binding site [chemical binding]; other site 288681000722 putative dimerization interface [polypeptide binding]; other site 288681000723 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681000724 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681000725 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681000726 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681000727 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 288681000728 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 288681000729 active site 288681000730 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 288681000731 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 288681000732 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 288681000733 lysozyme catalytic site [active] 288681000734 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 288681000735 nucleotide binding site/active site [active] 288681000736 HIT family signature motif; other site 288681000737 catalytic residue [active] 288681000738 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681000739 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681000740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681000741 ABC transporter; Region: ABC_tran_2; pfam12848 288681000742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681000743 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288681000744 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 288681000745 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681000746 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000747 dimer interface [polypeptide binding]; other site 288681000748 conserved gate region; other site 288681000749 putative PBP binding loops; other site 288681000750 ABC-ATPase subunit interface; other site 288681000751 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681000752 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681000753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681000754 dimer interface [polypeptide binding]; other site 288681000755 conserved gate region; other site 288681000756 putative PBP binding loops; other site 288681000757 ABC-ATPase subunit interface; other site 288681000758 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681000759 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681000760 Walker A/P-loop; other site 288681000761 ATP binding site [chemical binding]; other site 288681000762 Q-loop/lid; other site 288681000763 ABC transporter signature motif; other site 288681000764 Walker B; other site 288681000765 D-loop; other site 288681000766 H-loop/switch region; other site 288681000767 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681000768 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 288681000769 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681000770 Walker A/P-loop; other site 288681000771 ATP binding site [chemical binding]; other site 288681000772 Q-loop/lid; other site 288681000773 ABC transporter signature motif; other site 288681000774 Walker B; other site 288681000775 D-loop; other site 288681000776 H-loop/switch region; other site 288681000777 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681000778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681000779 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681000780 active site 288681000781 motif I; other site 288681000782 motif II; other site 288681000783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681000784 motif II; other site 288681000785 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 288681000786 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 288681000787 dimer interface [polypeptide binding]; other site 288681000788 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 288681000789 active site 288681000790 Fe binding site [ion binding]; other site 288681000791 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 288681000792 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 288681000793 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 288681000794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681000795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681000796 putative substrate translocation pore; other site 288681000797 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 288681000798 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 288681000799 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 288681000800 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 288681000801 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681000802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681000803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681000804 helicase 45; Provisional; Region: PTZ00424 288681000805 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681000806 ATP binding site [chemical binding]; other site 288681000807 Mg++ binding site [ion binding]; other site 288681000808 motif III; other site 288681000809 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681000810 nucleotide binding region [chemical binding]; other site 288681000811 ATP-binding site [chemical binding]; other site 288681000812 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 288681000813 Rhomboid family; Region: Rhomboid; pfam01694 288681000814 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 288681000815 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 288681000816 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 288681000817 alanine racemase; Reviewed; Region: alr; PRK00053 288681000818 active site 288681000819 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681000820 dimer interface [polypeptide binding]; other site 288681000821 substrate binding site [chemical binding]; other site 288681000822 catalytic residues [active] 288681000823 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 288681000824 PemK-like protein; Region: PemK; pfam02452 288681000825 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 288681000826 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 288681000827 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 288681000828 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 288681000829 RNA binding site [nucleotide binding]; other site 288681000830 hypothetical protein; Provisional; Region: PRK04351 288681000831 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 288681000832 Glycoprotease family; Region: Peptidase_M22; pfam00814 288681000833 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 288681000834 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 288681000835 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681000836 Coenzyme A binding pocket [chemical binding]; other site 288681000837 UGMP family protein; Validated; Region: PRK09604 288681000838 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 288681000839 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 288681000840 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681000841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681000842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681000843 ABC transporter; Region: ABC_tran_2; pfam12848 288681000844 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681000845 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 288681000846 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 288681000847 CoA binding domain; Region: CoA_binding; pfam02629 288681000848 CAAX protease self-immunity; Region: Abi; pfam02517 288681000849 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 288681000850 oligomerisation interface [polypeptide binding]; other site 288681000851 mobile loop; other site 288681000852 roof hairpin; other site 288681000853 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 288681000854 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 288681000855 ring oligomerisation interface [polypeptide binding]; other site 288681000856 ATP/Mg binding site [chemical binding]; other site 288681000857 stacking interactions; other site 288681000858 hinge regions; other site 288681000859 Uncharacterized conserved protein [Function unknown]; Region: COG5444 288681000860 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 288681000861 GMP synthase; Reviewed; Region: guaA; PRK00074 288681000862 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 288681000863 AMP/PPi binding site [chemical binding]; other site 288681000864 candidate oxyanion hole; other site 288681000865 catalytic triad [active] 288681000866 potential glutamine specificity residues [chemical binding]; other site 288681000867 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 288681000868 ATP Binding subdomain [chemical binding]; other site 288681000869 Ligand Binding sites [chemical binding]; other site 288681000870 Dimerization subdomain; other site 288681000871 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681000872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681000873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681000874 active site 288681000875 phosphorylation site [posttranslational modification] 288681000876 intermolecular recognition site; other site 288681000877 dimerization interface [polypeptide binding]; other site 288681000878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681000879 DNA binding site [nucleotide binding] 288681000880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681000881 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681000882 dimerization interface [polypeptide binding]; other site 288681000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681000884 dimer interface [polypeptide binding]; other site 288681000885 phosphorylation site [posttranslational modification] 288681000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681000887 ATP binding site [chemical binding]; other site 288681000888 Mg2+ binding site [ion binding]; other site 288681000889 G-X-G motif; other site 288681000890 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681000891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681000892 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288681000893 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 288681000894 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 288681000895 catalytic residues [active] 288681000896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000897 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681000898 NAD(P) binding site [chemical binding]; other site 288681000899 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681000900 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 288681000901 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681000902 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681000903 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681000904 Walker A/P-loop; other site 288681000905 ATP binding site [chemical binding]; other site 288681000906 Q-loop/lid; other site 288681000907 ABC transporter signature motif; other site 288681000908 Walker B; other site 288681000909 D-loop; other site 288681000910 H-loop/switch region; other site 288681000911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681000912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681000913 dimer interface [polypeptide binding]; other site 288681000914 phosphorylation site [posttranslational modification] 288681000915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681000916 ATP binding site [chemical binding]; other site 288681000917 Mg2+ binding site [ion binding]; other site 288681000918 G-X-G motif; other site 288681000919 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681000920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681000921 active site 288681000922 phosphorylation site [posttranslational modification] 288681000923 intermolecular recognition site; other site 288681000924 dimerization interface [polypeptide binding]; other site 288681000925 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681000926 DNA binding site [nucleotide binding] 288681000927 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681000928 EamA-like transporter family; Region: EamA; pfam00892 288681000929 EamA-like transporter family; Region: EamA; pfam00892 288681000930 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 288681000931 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 288681000932 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 288681000933 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 288681000934 NAD binding site [chemical binding]; other site 288681000935 ATP-grasp domain; Region: ATP-grasp; pfam02222 288681000936 adenylosuccinate lyase; Provisional; Region: PRK07492 288681000937 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 288681000938 tetramer interface [polypeptide binding]; other site 288681000939 active site 288681000940 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 288681000941 ATP binding site [chemical binding]; other site 288681000942 active site 288681000943 substrate binding site [chemical binding]; other site 288681000944 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 288681000945 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 288681000946 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 288681000947 putative active site [active] 288681000948 catalytic triad [active] 288681000949 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 288681000950 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 288681000951 dimerization interface [polypeptide binding]; other site 288681000952 ATP binding site [chemical binding]; other site 288681000953 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 288681000954 dimerization interface [polypeptide binding]; other site 288681000955 ATP binding site [chemical binding]; other site 288681000956 amidophosphoribosyltransferase; Provisional; Region: PRK06781 288681000957 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 288681000958 active site 288681000959 tetramer interface [polypeptide binding]; other site 288681000960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681000961 active site 288681000962 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 288681000963 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 288681000964 dimerization interface [polypeptide binding]; other site 288681000965 putative ATP binding site [chemical binding]; other site 288681000966 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 288681000967 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 288681000968 active site 288681000969 substrate binding site [chemical binding]; other site 288681000970 cosubstrate binding site; other site 288681000971 catalytic site [active] 288681000972 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 288681000973 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 288681000974 purine monophosphate binding site [chemical binding]; other site 288681000975 dimer interface [polypeptide binding]; other site 288681000976 putative catalytic residues [active] 288681000977 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 288681000978 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 288681000979 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 288681000980 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 288681000981 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 288681000982 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 288681000983 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 288681000984 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 288681000985 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 288681000986 PcrB family; Region: PcrB; pfam01884 288681000987 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 288681000988 substrate binding site [chemical binding]; other site 288681000989 putative active site [active] 288681000990 dimer interface [polypeptide binding]; other site 288681000991 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 288681000992 Part of AAA domain; Region: AAA_19; pfam13245 288681000993 Family description; Region: UvrD_C_2; pfam13538 288681000994 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 288681000995 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 288681000996 nucleotide binding pocket [chemical binding]; other site 288681000997 K-X-D-G motif; other site 288681000998 catalytic site [active] 288681000999 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 288681001000 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 288681001001 Dimer interface [polypeptide binding]; other site 288681001002 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 288681001003 putative dimer interface [polypeptide binding]; other site 288681001004 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 288681001005 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 288681001006 putative dimer interface [polypeptide binding]; other site 288681001007 hypothetical protein; Provisional; Region: PRK10621 288681001008 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681001009 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 288681001010 Glutamate binding site [chemical binding]; other site 288681001011 homodimer interface [polypeptide binding]; other site 288681001012 NAD binding site [chemical binding]; other site 288681001013 catalytic residues [active] 288681001014 Isochorismatase family; Region: Isochorismatase; pfam00857 288681001015 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681001016 catalytic triad [active] 288681001017 conserved cis-peptide bond; other site 288681001018 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 288681001019 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 288681001020 Walker A/P-loop; other site 288681001021 ATP binding site [chemical binding]; other site 288681001022 Q-loop/lid; other site 288681001023 ABC transporter signature motif; other site 288681001024 Walker B; other site 288681001025 D-loop; other site 288681001026 H-loop/switch region; other site 288681001027 NIL domain; Region: NIL; pfam09383 288681001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001029 dimer interface [polypeptide binding]; other site 288681001030 conserved gate region; other site 288681001031 putative PBP binding loops; other site 288681001032 ABC-ATPase subunit interface; other site 288681001033 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 288681001034 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 288681001035 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 288681001036 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 288681001037 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 288681001038 P loop; other site 288681001039 Nucleotide binding site [chemical binding]; other site 288681001040 DTAP/Switch II; other site 288681001041 Switch I; other site 288681001042 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 288681001043 putative dimer interface [polypeptide binding]; other site 288681001044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681001045 MarR family; Region: MarR; pfam01047 288681001046 MarR family; Region: MarR_2; cl17246 288681001047 yiaA/B two helix domain; Region: YiaAB; pfam05360 288681001048 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 288681001049 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 288681001050 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 288681001051 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 288681001052 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 288681001053 GatB domain; Region: GatB_Yqey; pfam02637 288681001054 putative lipid kinase; Reviewed; Region: PRK13337 288681001055 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 288681001056 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 288681001057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288681001058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001059 S-adenosylmethionine binding site [chemical binding]; other site 288681001060 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681001061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681001062 motif II; other site 288681001063 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 288681001064 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681001065 inhibitor-cofactor binding pocket; inhibition site 288681001066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001067 catalytic residue [active] 288681001068 PAS domain; Region: PAS_9; pfam13426 288681001069 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681001070 putative active site [active] 288681001071 heme pocket [chemical binding]; other site 288681001072 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 288681001073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001074 Walker A motif; other site 288681001075 ATP binding site [chemical binding]; other site 288681001076 Walker B motif; other site 288681001077 arginine finger; other site 288681001078 succinic semialdehyde dehydrogenase; Region: PLN02278 288681001079 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 288681001080 tetramerization interface [polypeptide binding]; other site 288681001081 NAD(P) binding site [chemical binding]; other site 288681001082 catalytic residues [active] 288681001083 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 288681001084 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 288681001085 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 288681001086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681001087 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 288681001088 putative active site [active] 288681001089 putative metal binding site [ion binding]; other site 288681001090 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681001091 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 288681001092 putative active site [active] 288681001093 putative metal binding site [ion binding]; other site 288681001094 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681001095 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681001096 Nucleoside recognition; Region: Gate; pfam07670 288681001097 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681001098 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 288681001099 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 288681001100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001101 S-adenosylmethionine binding site [chemical binding]; other site 288681001102 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 288681001103 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 288681001104 FMN binding site [chemical binding]; other site 288681001105 active site 288681001106 catalytic residues [active] 288681001107 substrate binding site [chemical binding]; other site 288681001108 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 288681001109 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 288681001110 GAF domain; Region: GAF_3; pfam13492 288681001111 GAF domain; Region: GAF_2; pfam13185 288681001112 PAS domain; Region: PAS_9; pfam13426 288681001113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001114 dimer interface [polypeptide binding]; other site 288681001115 phosphorylation site [posttranslational modification] 288681001116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001117 ATP binding site [chemical binding]; other site 288681001118 Mg2+ binding site [ion binding]; other site 288681001119 G-X-G motif; other site 288681001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 288681001121 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 288681001122 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 288681001123 Protein of unknown function DUF45; Region: DUF45; pfam01863 288681001124 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 288681001125 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 288681001126 active site 288681001127 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 288681001128 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 288681001129 amidohydrolase; Region: amidohydrolases; TIGR01891 288681001130 metal binding site [ion binding]; metal-binding site 288681001131 putative dimer interface [polypeptide binding]; other site 288681001132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001133 S-adenosylmethionine binding site [chemical binding]; other site 288681001134 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 288681001135 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 288681001136 catalytic residue [active] 288681001137 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 288681001138 catalytic residues [active] 288681001139 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681001140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681001141 peroxiredoxin; Region: AhpC; TIGR03137 288681001142 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 288681001143 dimer interface [polypeptide binding]; other site 288681001144 decamer (pentamer of dimers) interface [polypeptide binding]; other site 288681001145 catalytic triad [active] 288681001146 peroxidatic and resolving cysteines [active] 288681001147 5-methylribose kinase; Reviewed; Region: PRK12396 288681001148 Phosphotransferase enzyme family; Region: APH; pfam01636 288681001149 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 288681001150 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 288681001151 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 288681001152 intersubunit interface [polypeptide binding]; other site 288681001153 active site 288681001154 Zn2+ binding site [ion binding]; other site 288681001155 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681001156 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001157 ABC-ATPase subunit interface; other site 288681001158 dimer interface [polypeptide binding]; other site 288681001159 putative PBP binding regions; other site 288681001160 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681001161 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001162 ABC-ATPase subunit interface; other site 288681001163 dimer interface [polypeptide binding]; other site 288681001164 putative PBP binding regions; other site 288681001165 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681001166 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681001167 putative ligand binding residues [chemical binding]; other site 288681001168 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 288681001169 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681001170 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 288681001171 DNA binding domain, excisionase family; Region: excise; TIGR01764 288681001172 Sm and related proteins; Region: Sm_like; cl00259 288681001173 Sm1 motif; other site 288681001174 RNA binding site [nucleotide binding]; other site 288681001175 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 288681001176 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 288681001177 hypothetical protein; Provisional; Region: PRK06851 288681001178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001179 Walker A motif; other site 288681001180 ATP binding site [chemical binding]; other site 288681001181 NTPase; Region: NTPase_1; cl17478 288681001182 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 288681001183 benzoate transport; Region: 2A0115; TIGR00895 288681001184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001185 putative substrate translocation pore; other site 288681001186 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 288681001187 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681001188 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 288681001189 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 288681001190 [2Fe-2S] cluster binding site [ion binding]; other site 288681001191 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 288681001192 putative di-iron ligands [ion binding]; other site 288681001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001194 dimer interface [polypeptide binding]; other site 288681001195 conserved gate region; other site 288681001196 putative PBP binding loops; other site 288681001197 ABC-ATPase subunit interface; other site 288681001198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681001199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681001200 substrate binding pocket [chemical binding]; other site 288681001201 membrane-bound complex binding site; other site 288681001202 hinge residues; other site 288681001203 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681001204 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288681001205 Walker A/P-loop; other site 288681001206 ATP binding site [chemical binding]; other site 288681001207 Q-loop/lid; other site 288681001208 ABC transporter signature motif; other site 288681001209 Walker B; other site 288681001210 D-loop; other site 288681001211 H-loop/switch region; other site 288681001212 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681001213 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681001214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001215 dimerization interface [polypeptide binding]; other site 288681001216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001217 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001218 dimer interface [polypeptide binding]; other site 288681001219 putative CheW interface [polypeptide binding]; other site 288681001220 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681001221 HAMP domain; Region: HAMP; pfam00672 288681001222 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001223 dimer interface [polypeptide binding]; other site 288681001224 putative CheW interface [polypeptide binding]; other site 288681001225 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 288681001226 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 288681001227 Ca binding site [ion binding]; other site 288681001228 active site 288681001229 catalytic site [active] 288681001230 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 288681001231 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 288681001232 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681001233 active site turn [active] 288681001234 phosphorylation site [posttranslational modification] 288681001235 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 288681001236 putative catalytic site [active] 288681001237 putative metal binding site [ion binding]; other site 288681001238 putative phosphate binding site [ion binding]; other site 288681001239 Predicted membrane protein [Function unknown]; Region: COG1511 288681001240 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681001241 Predicted membrane protein [Function unknown]; Region: COG1511 288681001242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001243 DNA topoisomerase III; Provisional; Region: PRK07726 288681001244 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 288681001245 active site 288681001246 putative interdomain interaction site [polypeptide binding]; other site 288681001247 putative metal-binding site [ion binding]; other site 288681001248 putative nucleotide binding site [chemical binding]; other site 288681001249 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288681001250 domain I; other site 288681001251 DNA binding groove [nucleotide binding] 288681001252 phosphate binding site [ion binding]; other site 288681001253 domain II; other site 288681001254 domain III; other site 288681001255 nucleotide binding site [chemical binding]; other site 288681001256 catalytic site [active] 288681001257 domain IV; other site 288681001258 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 288681001259 substrate binding site [chemical binding]; other site 288681001260 multimerization interface [polypeptide binding]; other site 288681001261 ATP binding site [chemical binding]; other site 288681001262 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 288681001263 thiamine phosphate binding site [chemical binding]; other site 288681001264 active site 288681001265 pyrophosphate binding site [ion binding]; other site 288681001266 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681001267 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 288681001268 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 288681001269 HAMP domain; Region: HAMP; pfam00672 288681001270 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681001271 dimerization interface [polypeptide binding]; other site 288681001272 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001273 dimer interface [polypeptide binding]; other site 288681001274 putative CheW interface [polypeptide binding]; other site 288681001275 Domain of unknown function DUF77; Region: DUF77; pfam01910 288681001276 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288681001277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001278 dimer interface [polypeptide binding]; other site 288681001279 conserved gate region; other site 288681001280 putative PBP binding loops; other site 288681001281 ABC-ATPase subunit interface; other site 288681001282 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 288681001283 NMT1/THI5 like; Region: NMT1; pfam09084 288681001284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681001285 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 288681001286 Walker A/P-loop; other site 288681001287 ATP binding site [chemical binding]; other site 288681001288 Q-loop/lid; other site 288681001289 ABC transporter signature motif; other site 288681001290 Walker B; other site 288681001291 D-loop; other site 288681001292 H-loop/switch region; other site 288681001293 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681001294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681001295 Walker A/P-loop; other site 288681001296 ATP binding site [chemical binding]; other site 288681001297 Q-loop/lid; other site 288681001298 ABC transporter signature motif; other site 288681001299 Walker B; other site 288681001300 D-loop; other site 288681001301 H-loop/switch region; other site 288681001302 ABC transporter; Region: ABC_tran_2; pfam12848 288681001303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681001304 Glyco_18 domain; Region: Glyco_18; smart00636 288681001305 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 288681001306 active site 288681001307 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681001308 Interdomain contacts; other site 288681001309 Cytokine receptor motif; other site 288681001310 Cellulose binding domain; Region: CBM_2; pfam00553 288681001311 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 288681001312 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681001313 catalytic residues [active] 288681001314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681001315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681001316 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 288681001317 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681001318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001319 putative substrate translocation pore; other site 288681001320 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681001321 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681001322 non-specific DNA binding site [nucleotide binding]; other site 288681001323 salt bridge; other site 288681001324 sequence-specific DNA binding site [nucleotide binding]; other site 288681001325 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 288681001326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001327 putative substrate translocation pore; other site 288681001328 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 288681001329 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 288681001330 YesK-like protein; Region: YesK; pfam14150 288681001331 prolyl-tRNA synthetase; Provisional; Region: PRK08661 288681001332 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 288681001333 dimer interface [polypeptide binding]; other site 288681001334 motif 1; other site 288681001335 active site 288681001336 motif 2; other site 288681001337 motif 3; other site 288681001338 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 288681001339 anticodon binding site; other site 288681001340 zinc-binding site [ion binding]; other site 288681001341 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681001342 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681001343 nucleotide binding site [chemical binding]; other site 288681001344 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 288681001345 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 288681001346 putative metal binding site [ion binding]; other site 288681001347 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 288681001348 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 288681001349 putative metal binding site [ion binding]; other site 288681001350 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 288681001351 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 288681001352 putative metal binding site [ion binding]; other site 288681001353 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 288681001354 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 288681001355 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 288681001356 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 288681001357 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 288681001358 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 288681001359 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681001360 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 288681001361 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 288681001362 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 288681001363 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 288681001364 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 288681001365 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288681001366 active site 288681001367 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 288681001368 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 288681001369 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 288681001370 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681001371 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288681001372 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681001373 EamA-like transporter family; Region: EamA; pfam00892 288681001374 EamA-like transporter family; Region: EamA; pfam00892 288681001375 YhhN-like protein; Region: YhhN; pfam07947 288681001376 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681001377 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681001378 Catalytic site [active] 288681001379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681001380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681001381 binding surface 288681001382 TPR motif; other site 288681001383 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681001384 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288681001385 Predicted membrane protein [Function unknown]; Region: COG2510 288681001386 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 288681001387 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 288681001388 calcium/proton exchanger (cax); Region: cax; TIGR00378 288681001389 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 288681001390 YfkD-like protein; Region: YfkD; pfam14167 288681001391 Radical SAM superfamily; Region: Radical_SAM; pfam04055 288681001392 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681001393 FeS/SAM binding site; other site 288681001394 YfkB-like domain; Region: YfkB; pfam08756 288681001395 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 288681001396 Fumarase C-terminus; Region: Fumerase_C; pfam05683 288681001397 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 288681001398 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 288681001399 NodB motif; other site 288681001400 active site 288681001401 catalytic site [active] 288681001402 Cd binding site [ion binding]; other site 288681001403 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681001404 endonuclease III; Region: ENDO3c; smart00478 288681001405 minor groove reading motif; other site 288681001406 helix-hairpin-helix signature motif; other site 288681001407 substrate binding pocket [chemical binding]; other site 288681001408 active site 288681001409 TRAM domain; Region: TRAM; pfam01938 288681001410 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 288681001411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001412 S-adenosylmethionine binding site [chemical binding]; other site 288681001413 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 288681001414 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 288681001415 dimerization interface 3.5A [polypeptide binding]; other site 288681001416 active site 288681001417 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 288681001418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001419 Walker A motif; other site 288681001420 ATP binding site [chemical binding]; other site 288681001421 Walker B motif; other site 288681001422 arginine finger; other site 288681001423 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 288681001424 hypothetical protein; Validated; Region: PRK06748 288681001425 S-methylmethionine transporter; Provisional; Region: PRK11387 288681001426 acetylornithine deacetylase; Validated; Region: PRK08596 288681001427 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288681001428 metal binding site [ion binding]; metal-binding site 288681001429 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681001430 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681001431 non-specific DNA binding site [nucleotide binding]; other site 288681001432 salt bridge; other site 288681001433 sequence-specific DNA binding site [nucleotide binding]; other site 288681001434 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 288681001435 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 288681001436 Domain of unknown function DUF; Region: DUF204; pfam02659 288681001437 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 288681001438 glutaminase A; Region: Gln_ase; TIGR03814 288681001439 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 288681001440 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 288681001441 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681001442 active site turn [active] 288681001443 phosphorylation site [posttranslational modification] 288681001444 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681001445 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681001446 Sm and related proteins; Region: Sm_like; cl00259 288681001447 heptamer interface [polypeptide binding]; other site 288681001448 Sm1 motif; other site 288681001449 hexamer interface [polypeptide binding]; other site 288681001450 RNA binding site [nucleotide binding]; other site 288681001451 Sm2 motif; other site 288681001452 Sm and related proteins; Region: Sm_like; cl00259 288681001453 heptamer interface [polypeptide binding]; other site 288681001454 Sm1 motif; other site 288681001455 hexamer interface [polypeptide binding]; other site 288681001456 RNA binding site [nucleotide binding]; other site 288681001457 Sm2 motif; other site 288681001458 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681001459 Ligand binding site; other site 288681001460 Putative Catalytic site; other site 288681001461 DXD motif; other site 288681001462 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 288681001463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 288681001464 active site 288681001465 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 288681001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001467 NAD(P) binding site [chemical binding]; other site 288681001468 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288681001469 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 288681001470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681001471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681001472 NAD(P) binding site [chemical binding]; other site 288681001473 active site 288681001474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681001475 active site 288681001476 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 288681001477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681001478 active site 288681001479 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 288681001480 Pyruvate formate lyase 1; Region: PFL1; cd01678 288681001481 coenzyme A binding site [chemical binding]; other site 288681001482 active site 288681001483 catalytic residues [active] 288681001484 glycine loop; other site 288681001485 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 288681001486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681001487 FeS/SAM binding site; other site 288681001488 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 288681001489 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 288681001490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681001491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681001492 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 288681001493 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 288681001494 active site 288681001495 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 288681001496 TIGR01777 family protein; Region: yfcH 288681001497 putative NAD(P) binding site [chemical binding]; other site 288681001498 putative active site [active] 288681001499 recombination regulator RecX; Provisional; Region: recX; PRK14135 288681001500 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 288681001501 WVELL protein; Region: WVELL; pfam14043 288681001502 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 288681001503 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 288681001504 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681001505 minor groove reading motif; other site 288681001506 helix-hairpin-helix signature motif; other site 288681001507 substrate binding pocket [chemical binding]; other site 288681001508 active site 288681001509 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 288681001510 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 288681001511 DNA binding and oxoG recognition site [nucleotide binding] 288681001512 small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; TIGR01442 288681001513 YgaB-like protein; Region: YgaB; pfam14182 288681001514 hypothetical protein; Provisional; Region: PRK13662 288681001515 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681001516 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681001517 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 288681001518 Walker A/P-loop; other site 288681001519 ATP binding site [chemical binding]; other site 288681001520 Q-loop/lid; other site 288681001521 ABC transporter signature motif; other site 288681001522 Walker B; other site 288681001523 D-loop; other site 288681001524 H-loop/switch region; other site 288681001525 Predicted membrane protein [Function unknown]; Region: COG4129 288681001526 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 288681001527 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 288681001528 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 288681001529 active site 288681001530 dimer interface [polypeptide binding]; other site 288681001531 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 288681001532 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 288681001533 active site 288681001534 FMN binding site [chemical binding]; other site 288681001535 substrate binding site [chemical binding]; other site 288681001536 3Fe-4S cluster binding site [ion binding]; other site 288681001537 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 288681001538 domain_subunit interface; other site 288681001539 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 288681001540 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681001541 inhibitor-cofactor binding pocket; inhibition site 288681001542 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001543 catalytic residue [active] 288681001544 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 288681001545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681001546 Walker A/P-loop; other site 288681001547 ATP binding site [chemical binding]; other site 288681001548 Q-loop/lid; other site 288681001549 ABC transporter signature motif; other site 288681001550 Walker B; other site 288681001551 D-loop; other site 288681001552 H-loop/switch region; other site 288681001553 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 288681001554 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 288681001555 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 288681001556 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 288681001557 Ion channel; Region: Ion_trans_2; pfam07885 288681001558 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 288681001559 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 288681001560 catalytic triad [active] 288681001561 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288681001562 metal binding site 2 [ion binding]; metal-binding site 288681001563 putative DNA binding helix; other site 288681001564 metal binding site 1 [ion binding]; metal-binding site 288681001565 dimer interface [polypeptide binding]; other site 288681001566 structural Zn2+ binding site [ion binding]; other site 288681001567 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 288681001568 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 288681001569 hypothetical protein; Provisional; Region: PRK12378 288681001570 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681001571 nudix motif; other site 288681001572 Transglycosylase; Region: Transgly; pfam00912 288681001573 Thioredoxin; Region: Thioredoxin_4; pfam13462 288681001574 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 288681001575 epoxyqueuosine reductase; Region: TIGR00276 288681001576 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 288681001577 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 288681001578 HEAT-like repeat; Region: HEAT_EZ; pfam13513 288681001579 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 288681001580 Putative amidase domain; Region: Amidase_6; pfam12671 288681001581 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 288681001582 PAS fold; Region: PAS_4; pfam08448 288681001583 PAS domain S-box; Region: sensory_box; TIGR00229 288681001584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681001585 putative active site [active] 288681001586 heme pocket [chemical binding]; other site 288681001587 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681001588 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681001589 metal binding site [ion binding]; metal-binding site 288681001590 active site 288681001591 I-site; other site 288681001592 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681001593 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 288681001594 PrkA AAA domain; Region: AAA_PrkA; smart00763 288681001595 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 288681001596 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 288681001597 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681001598 heme-binding site [chemical binding]; other site 288681001599 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001600 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001601 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 288681001602 Substrate binding site [chemical binding]; other site 288681001603 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001604 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001605 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001606 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001607 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001608 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 288681001609 Leucine-rich repeats; other site 288681001610 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001611 Leucine rich repeat; Region: LRR_8; pfam13855 288681001612 Substrate binding site [chemical binding]; other site 288681001613 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681001614 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681001615 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681001616 Coenzyme A binding pocket [chemical binding]; other site 288681001617 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 288681001618 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681001619 substrate binding pocket [chemical binding]; other site 288681001620 membrane-bound complex binding site; other site 288681001621 hinge residues; other site 288681001622 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681001623 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288681001624 Walker A/P-loop; other site 288681001625 ATP binding site [chemical binding]; other site 288681001626 Q-loop/lid; other site 288681001627 ABC transporter signature motif; other site 288681001628 Walker B; other site 288681001629 D-loop; other site 288681001630 H-loop/switch region; other site 288681001631 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288681001632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001633 dimer interface [polypeptide binding]; other site 288681001634 conserved gate region; other site 288681001635 putative PBP binding loops; other site 288681001636 ABC-ATPase subunit interface; other site 288681001637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001638 dimer interface [polypeptide binding]; other site 288681001639 conserved gate region; other site 288681001640 putative PBP binding loops; other site 288681001641 ABC-ATPase subunit interface; other site 288681001642 BCCT family transporter; Region: BCCT; pfam02028 288681001643 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 288681001644 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681001645 FOG: PKD repeat [General function prediction only]; Region: COG3291 288681001646 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 288681001647 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681001648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 288681001649 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 288681001650 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681001651 Cache domain; Region: Cache_1; pfam02743 288681001652 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001653 dimerization interface [polypeptide binding]; other site 288681001654 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681001655 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001656 dimer interface [polypeptide binding]; other site 288681001657 putative CheW interface [polypeptide binding]; other site 288681001658 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 288681001659 PAS domain; Region: PAS; smart00091 288681001660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001661 ATP binding site [chemical binding]; other site 288681001662 Mg2+ binding site [ion binding]; other site 288681001663 G-X-G motif; other site 288681001664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001665 active site 288681001666 phosphorylation site [posttranslational modification] 288681001667 intermolecular recognition site; other site 288681001668 dimerization interface [polypeptide binding]; other site 288681001669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681001670 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681001671 Probable transposase; Region: OrfB_IS605; pfam01385 288681001672 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 288681001673 Citrate transporter; Region: CitMHS; pfam03600 288681001674 hypothetical protein; Provisional; Region: PRK12784 288681001675 NosL; Region: NosL; cl01769 288681001676 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681001677 Ankyrin repeat; Region: Ank; pfam00023 288681001678 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681001679 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681001680 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681001681 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 288681001682 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288681001683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681001684 Walker A/P-loop; other site 288681001685 ATP binding site [chemical binding]; other site 288681001686 Q-loop/lid; other site 288681001687 ABC transporter signature motif; other site 288681001688 Walker B; other site 288681001689 D-loop; other site 288681001690 H-loop/switch region; other site 288681001691 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 288681001692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001693 dimer interface [polypeptide binding]; other site 288681001694 conserved gate region; other site 288681001695 putative PBP binding loops; other site 288681001696 ABC-ATPase subunit interface; other site 288681001697 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288681001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681001699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001700 dimer interface [polypeptide binding]; other site 288681001701 conserved gate region; other site 288681001702 putative PBP binding loops; other site 288681001703 ABC-ATPase subunit interface; other site 288681001704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288681001705 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 288681001706 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681001707 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 288681001708 active site 288681001709 metal binding site [ion binding]; metal-binding site 288681001710 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001712 active site 288681001713 phosphorylation site [posttranslational modification] 288681001714 intermolecular recognition site; other site 288681001715 dimerization interface [polypeptide binding]; other site 288681001716 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681001717 DNA binding site [nucleotide binding] 288681001718 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681001719 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001720 dimer interface [polypeptide binding]; other site 288681001721 phosphorylation site [posttranslational modification] 288681001722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001723 ATP binding site [chemical binding]; other site 288681001724 Mg2+ binding site [ion binding]; other site 288681001725 G-X-G motif; other site 288681001726 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 288681001727 putative active site [active] 288681001728 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681001729 Cache domain; Region: Cache_1; pfam02743 288681001730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001731 dimerization interface [polypeptide binding]; other site 288681001732 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681001733 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681001734 dimer interface [polypeptide binding]; other site 288681001735 putative CheW interface [polypeptide binding]; other site 288681001736 sensory histidine kinase DcuS; Provisional; Region: PRK11086 288681001737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001738 ATP binding site [chemical binding]; other site 288681001739 Mg2+ binding site [ion binding]; other site 288681001740 G-X-G motif; other site 288681001741 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 288681001742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001743 active site 288681001744 phosphorylation site [posttranslational modification] 288681001745 intermolecular recognition site; other site 288681001746 dimerization interface [polypeptide binding]; other site 288681001747 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 288681001748 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 288681001749 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288681001750 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 288681001751 putative NAD(P) binding site [chemical binding]; other site 288681001752 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681001753 EamA-like transporter family; Region: EamA; pfam00892 288681001754 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681001755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681001756 DNA-binding site [nucleotide binding]; DNA binding site 288681001757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681001758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001759 homodimer interface [polypeptide binding]; other site 288681001760 catalytic residue [active] 288681001761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681001762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681001763 Coenzyme A binding pocket [chemical binding]; other site 288681001764 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681001765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681001766 dimerization interface [polypeptide binding]; other site 288681001767 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681001768 dimer interface [polypeptide binding]; other site 288681001769 phosphorylation site [posttranslational modification] 288681001770 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681001771 ATP binding site [chemical binding]; other site 288681001772 Mg2+ binding site [ion binding]; other site 288681001773 G-X-G motif; other site 288681001774 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681001775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681001776 active site 288681001777 phosphorylation site [posttranslational modification] 288681001778 intermolecular recognition site; other site 288681001779 dimerization interface [polypeptide binding]; other site 288681001780 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681001781 DNA binding site [nucleotide binding] 288681001782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681001783 Arrestin_N terminal like; Region: LDB19; pfam13002 288681001784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681001785 Coenzyme A binding pocket [chemical binding]; other site 288681001786 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 288681001787 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 288681001788 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 288681001789 catalytic loop [active] 288681001790 iron binding site [ion binding]; other site 288681001791 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 288681001792 4Fe-4S binding domain; Region: Fer4; pfam00037 288681001793 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 288681001794 [4Fe-4S] binding site [ion binding]; other site 288681001795 molybdopterin cofactor binding site; other site 288681001796 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 288681001797 molybdopterin cofactor binding site; other site 288681001798 Uncharacterized conserved protein [Function unknown]; Region: COG2427 288681001799 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 288681001800 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681001801 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 288681001802 putative active site [active] 288681001803 catalytic site [active] 288681001804 putative metal binding site [ion binding]; other site 288681001805 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 288681001806 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 288681001807 hexamer interface [polypeptide binding]; other site 288681001808 ligand binding site [chemical binding]; other site 288681001809 putative active site [active] 288681001810 NAD(P) binding site [chemical binding]; other site 288681001811 amino acid transporter; Region: 2A0306; TIGR00909 288681001812 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 288681001813 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681001814 dimerization interface [polypeptide binding]; other site 288681001815 putative DNA binding site [nucleotide binding]; other site 288681001816 putative Zn2+ binding site [ion binding]; other site 288681001817 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681001818 metal-binding site [ion binding] 288681001819 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288681001820 Heavy-metal-associated domain; Region: HMA; pfam00403 288681001821 metal-binding site [ion binding] 288681001822 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681001823 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288681001824 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 288681001825 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 288681001826 active site 288681001827 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681001828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681001829 non-specific DNA binding site [nucleotide binding]; other site 288681001830 salt bridge; other site 288681001831 sequence-specific DNA binding site [nucleotide binding]; other site 288681001832 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681001833 binding surface 288681001834 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681001835 TPR motif; other site 288681001836 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681001837 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681001838 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681001839 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681001840 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 288681001841 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681001842 active site 288681001843 Zn binding site [ion binding]; other site 288681001844 Uncharacterized conserved protein [Function unknown]; Region: COG0398 288681001845 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288681001846 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 288681001847 VanW like protein; Region: VanW; pfam04294 288681001848 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681001849 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681001850 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681001851 Nucleoside recognition; Region: Gate; pfam07670 288681001852 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681001853 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 288681001854 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681001855 putative metal binding site [ion binding]; other site 288681001856 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681001857 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681001858 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681001859 Transporter associated domain; Region: CorC_HlyC; smart01091 288681001860 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 288681001861 Aspartase; Region: Aspartase; cd01357 288681001862 active sites [active] 288681001863 tetramer interface [polypeptide binding]; other site 288681001864 L-lactate permease; Region: Lactate_perm; cl00701 288681001865 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 288681001866 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681001867 dimerization interface [polypeptide binding]; other site 288681001868 putative Zn2+ binding site [ion binding]; other site 288681001869 putative DNA binding site [nucleotide binding]; other site 288681001870 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 288681001871 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 288681001872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681001873 putative substrate translocation pore; other site 288681001874 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 288681001875 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 288681001876 siderophore binding site; other site 288681001877 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681001878 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001879 ABC-ATPase subunit interface; other site 288681001880 dimer interface [polypeptide binding]; other site 288681001881 putative PBP binding regions; other site 288681001882 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681001883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681001884 ABC-ATPase subunit interface; other site 288681001885 dimer interface [polypeptide binding]; other site 288681001886 putative PBP binding regions; other site 288681001887 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681001888 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681001889 Walker A/P-loop; other site 288681001890 ATP binding site [chemical binding]; other site 288681001891 Q-loop/lid; other site 288681001892 ABC transporter signature motif; other site 288681001893 Walker B; other site 288681001894 D-loop; other site 288681001895 H-loop/switch region; other site 288681001896 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681001897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681001898 S-adenosylmethionine binding site [chemical binding]; other site 288681001899 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 288681001900 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 288681001901 substrate-cofactor binding pocket; other site 288681001902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681001903 catalytic residue [active] 288681001904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681001905 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 288681001906 NAD binding site [chemical binding]; other site 288681001907 homodimer interface [polypeptide binding]; other site 288681001908 active site 288681001909 putative substrate binding site [chemical binding]; other site 288681001910 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681001911 active site 288681001912 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681001913 nudix motif; other site 288681001914 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 288681001915 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 288681001916 metal ion-dependent adhesion site (MIDAS); other site 288681001917 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681001918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681001919 Walker A motif; other site 288681001920 ATP binding site [chemical binding]; other site 288681001921 Walker B motif; other site 288681001922 arginine finger; other site 288681001923 cardiolipin synthetase; Reviewed; Region: PRK12452 288681001924 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288681001925 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681001926 putative active site [active] 288681001927 catalytic site [active] 288681001928 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681001929 putative active site [active] 288681001930 catalytic site [active] 288681001931 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681001932 PAS domain; Region: PAS_9; pfam13426 288681001933 putative active site [active] 288681001934 heme pocket [chemical binding]; other site 288681001935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681001936 metal binding site [ion binding]; metal-binding site 288681001937 active site 288681001938 I-site; other site 288681001939 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681001940 Amino acid permease; Region: AA_permease_2; pfam13520 288681001941 Spore germination protein; Region: Spore_permease; cl17796 288681001942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681001943 DNA-binding site [nucleotide binding]; DNA binding site 288681001944 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 288681001945 UTRA domain; Region: UTRA; pfam07702 288681001946 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 288681001947 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681001948 active site turn [active] 288681001949 phosphorylation site [posttranslational modification] 288681001950 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 288681001951 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 288681001952 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 288681001953 Ca binding site [ion binding]; other site 288681001954 active site 288681001955 catalytic site [active] 288681001956 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681001957 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681001958 Spore germination protein; Region: Spore_permease; cl17796 288681001959 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681001960 CAAX protease self-immunity; Region: Abi; pfam02517 288681001961 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681001962 active site 288681001963 ATP binding site [chemical binding]; other site 288681001964 substrate binding site [chemical binding]; other site 288681001965 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681001966 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 288681001967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681001968 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288681001969 Walker A/P-loop; other site 288681001970 ATP binding site [chemical binding]; other site 288681001971 Q-loop/lid; other site 288681001972 ABC transporter signature motif; other site 288681001973 Walker B; other site 288681001974 D-loop; other site 288681001975 H-loop/switch region; other site 288681001976 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 288681001977 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681001978 substrate binding pocket [chemical binding]; other site 288681001979 membrane-bound complex binding site; other site 288681001980 hinge residues; other site 288681001981 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 288681001982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001983 dimer interface [polypeptide binding]; other site 288681001984 conserved gate region; other site 288681001985 putative PBP binding loops; other site 288681001986 ABC-ATPase subunit interface; other site 288681001987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681001988 dimer interface [polypeptide binding]; other site 288681001989 conserved gate region; other site 288681001990 putative PBP binding loops; other site 288681001991 ABC-ATPase subunit interface; other site 288681001992 S-methylmethionine transporter; Provisional; Region: PRK11387 288681001993 OsmC-like protein; Region: OsmC; pfam02566 288681001994 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 288681001995 nucleotide binding site/active site [active] 288681001996 HIT family signature motif; other site 288681001997 catalytic residue [active] 288681001998 RNA polymerase sigma factor; Provisional; Region: PRK12542 288681001999 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681002000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681002001 DNA binding residues [nucleotide binding] 288681002002 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 288681002003 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681002004 HTH domain; Region: HTH_11; pfam08279 288681002005 WYL domain; Region: WYL; pfam13280 288681002006 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 288681002007 RibD C-terminal domain; Region: RibD_C; cl17279 288681002008 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681002009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681002010 dimerization interface [polypeptide binding]; other site 288681002011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681002012 dimer interface [polypeptide binding]; other site 288681002013 phosphorylation site [posttranslational modification] 288681002014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002015 ATP binding site [chemical binding]; other site 288681002016 Mg2+ binding site [ion binding]; other site 288681002017 G-X-G motif; other site 288681002018 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681002019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002020 active site 288681002021 phosphorylation site [posttranslational modification] 288681002022 intermolecular recognition site; other site 288681002023 dimerization interface [polypeptide binding]; other site 288681002024 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681002025 DNA binding site [nucleotide binding] 288681002026 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 288681002027 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 288681002028 Sulfate transporter family; Region: Sulfate_transp; pfam00916 288681002029 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 288681002030 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288681002031 Ligand Binding Site [chemical binding]; other site 288681002032 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 288681002033 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 288681002034 peptide binding site [polypeptide binding]; other site 288681002035 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 288681002036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002037 dimer interface [polypeptide binding]; other site 288681002038 conserved gate region; other site 288681002039 putative PBP binding loops; other site 288681002040 ABC-ATPase subunit interface; other site 288681002041 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681002042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002043 putative PBP binding loops; other site 288681002044 ABC-ATPase subunit interface; other site 288681002045 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288681002046 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681002047 Walker A/P-loop; other site 288681002048 ATP binding site [chemical binding]; other site 288681002049 Q-loop/lid; other site 288681002050 ABC transporter signature motif; other site 288681002051 Walker B; other site 288681002052 D-loop; other site 288681002053 H-loop/switch region; other site 288681002054 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 288681002055 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681002056 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681002057 Walker A/P-loop; other site 288681002058 ATP binding site [chemical binding]; other site 288681002059 Q-loop/lid; other site 288681002060 ABC transporter signature motif; other site 288681002061 Walker B; other site 288681002062 D-loop; other site 288681002063 H-loop/switch region; other site 288681002064 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681002065 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 288681002066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002067 putative substrate translocation pore; other site 288681002068 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681002069 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681002070 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681002071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002072 putative substrate translocation pore; other site 288681002073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681002074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681002075 DNA binding site [nucleotide binding] 288681002076 domain linker motif; other site 288681002077 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 288681002078 dimerization interface [polypeptide binding]; other site 288681002079 ligand binding site [chemical binding]; other site 288681002080 sodium binding site [ion binding]; other site 288681002081 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681002082 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 288681002083 substrate binding site [chemical binding]; other site 288681002084 dimer interface [polypeptide binding]; other site 288681002085 ATP binding site [chemical binding]; other site 288681002086 D-ribose pyranase; Provisional; Region: PRK11797 288681002087 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 288681002088 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 288681002089 Walker A/P-loop; other site 288681002090 ATP binding site [chemical binding]; other site 288681002091 Q-loop/lid; other site 288681002092 ABC transporter signature motif; other site 288681002093 Walker B; other site 288681002094 D-loop; other site 288681002095 H-loop/switch region; other site 288681002096 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 288681002097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288681002098 TM-ABC transporter signature motif; other site 288681002099 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 288681002100 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 288681002101 ligand binding site [chemical binding]; other site 288681002102 dimerization interface [polypeptide binding]; other site 288681002103 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 288681002104 active site 288681002105 intersubunit interactions; other site 288681002106 catalytic residue [active] 288681002107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 288681002108 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 288681002109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002111 putative substrate translocation pore; other site 288681002112 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681002113 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 288681002114 putative NAD(P) binding site [chemical binding]; other site 288681002115 catalytic Zn binding site [ion binding]; other site 288681002116 Ion channel; Region: Ion_trans_2; pfam07885 288681002117 Ion channel; Region: Ion_trans_2; pfam07885 288681002118 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 288681002119 Zn binding site [ion binding]; other site 288681002120 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 288681002121 putative catalytic site [active] 288681002122 metal binding site A [ion binding]; metal-binding site 288681002123 phosphate binding site [ion binding]; other site 288681002124 metal binding site C [ion binding]; metal-binding site 288681002125 metal binding site B [ion binding]; metal-binding site 288681002126 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 288681002127 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 288681002128 dimer interface [polypeptide binding]; other site 288681002129 active site 288681002130 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681002131 substrate binding site [chemical binding]; other site 288681002132 catalytic residue [active] 288681002133 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 288681002134 FAD binding domain; Region: FAD_binding_4; pfam01565 288681002135 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 288681002136 VanZ like family; Region: VanZ; pfam04892 288681002137 RDD family; Region: RDD; pfam06271 288681002138 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 288681002139 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681002140 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681002141 dimer interface [polypeptide binding]; other site 288681002142 putative CheW interface [polypeptide binding]; other site 288681002143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 288681002144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 288681002145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681002146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681002147 non-specific DNA binding site [nucleotide binding]; other site 288681002148 salt bridge; other site 288681002149 sequence-specific DNA binding site [nucleotide binding]; other site 288681002150 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 288681002151 active site 288681002152 catalytic site [active] 288681002153 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 288681002154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002155 putative substrate translocation pore; other site 288681002156 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 288681002157 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 288681002158 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 288681002159 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 288681002160 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681002161 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681002162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681002163 non-specific DNA binding site [nucleotide binding]; other site 288681002164 salt bridge; other site 288681002165 sequence-specific DNA binding site [nucleotide binding]; other site 288681002166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681002167 Coenzyme A binding pocket [chemical binding]; other site 288681002168 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 288681002169 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681002170 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681002171 TrkA-N domain; Region: TrkA_N; pfam02254 288681002172 TrkA-C domain; Region: TrkA_C; pfam02080 288681002173 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 288681002174 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 288681002175 Subunit I/III interface [polypeptide binding]; other site 288681002176 Subunit III/IV interface [polypeptide binding]; other site 288681002177 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 288681002178 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 288681002179 D-pathway; other site 288681002180 Putative ubiquinol binding site [chemical binding]; other site 288681002181 Low-spin heme (heme b) binding site [chemical binding]; other site 288681002182 Putative water exit pathway; other site 288681002183 Binuclear center (heme o3/CuB) [ion binding]; other site 288681002184 K-pathway; other site 288681002185 Putative proton exit pathway; other site 288681002186 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 288681002187 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 288681002188 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 288681002189 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 288681002190 putative active site [active] 288681002191 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681002192 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 288681002193 metal binding site [ion binding]; metal-binding site 288681002194 dimer interface [polypeptide binding]; other site 288681002195 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 288681002196 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 288681002197 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681002198 Na binding site [ion binding]; other site 288681002199 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681002200 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 288681002201 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681002202 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681002203 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 288681002204 Nucleoside recognition; Region: Gate; pfam07670 288681002205 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 288681002206 Nucleoside recognition; Region: Gate; pfam07670 288681002207 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 288681002208 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 288681002209 G1 box; other site 288681002210 GTP/Mg2+ binding site [chemical binding]; other site 288681002211 Switch I region; other site 288681002212 G2 box; other site 288681002213 G3 box; other site 288681002214 Switch II region; other site 288681002215 G4 box; other site 288681002216 G5 box; other site 288681002217 FeoA domain; Region: FeoA; pfam04023 288681002218 phosphate binding protein; Region: ptsS_2; TIGR02136 288681002219 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 288681002220 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 288681002221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002222 dimer interface [polypeptide binding]; other site 288681002223 conserved gate region; other site 288681002224 putative PBP binding loops; other site 288681002225 ABC-ATPase subunit interface; other site 288681002226 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 288681002227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002228 dimer interface [polypeptide binding]; other site 288681002229 conserved gate region; other site 288681002230 putative PBP binding loops; other site 288681002231 ABC-ATPase subunit interface; other site 288681002232 AAA domain; Region: AAA_33; pfam13671 288681002233 AAA domain; Region: AAA_17; pfam13207 288681002234 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 288681002235 FOG: CBS domain [General function prediction only]; Region: COG0517 288681002236 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 288681002237 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 288681002238 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 288681002239 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681002240 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681002241 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681002242 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681002243 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681002244 Putative transcription activator [Transcription]; Region: TenA; COG0819 288681002245 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681002246 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 288681002247 Walker A/P-loop; other site 288681002248 ATP binding site [chemical binding]; other site 288681002249 Q-loop/lid; other site 288681002250 ABC transporter signature motif; other site 288681002251 Walker B; other site 288681002252 D-loop; other site 288681002253 H-loop/switch region; other site 288681002254 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288681002255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002256 dimer interface [polypeptide binding]; other site 288681002257 conserved gate region; other site 288681002258 putative PBP binding loops; other site 288681002259 ABC-ATPase subunit interface; other site 288681002260 NMT1/THI5 like; Region: NMT1; pfam09084 288681002261 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 288681002262 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 288681002263 thiamine phosphate binding site [chemical binding]; other site 288681002264 active site 288681002265 pyrophosphate binding site [ion binding]; other site 288681002266 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 288681002267 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 288681002268 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 288681002269 thiS-thiF/thiG interaction site; other site 288681002270 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 288681002271 ThiS interaction site; other site 288681002272 putative active site [active] 288681002273 tetramer interface [polypeptide binding]; other site 288681002274 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 288681002275 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681002276 ATP binding site [chemical binding]; other site 288681002277 substrate interface [chemical binding]; other site 288681002278 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 288681002279 dimer interface [polypeptide binding]; other site 288681002280 substrate binding site [chemical binding]; other site 288681002281 ATP binding site [chemical binding]; other site 288681002282 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 288681002283 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 288681002284 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681002285 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288681002286 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 288681002287 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 288681002288 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 288681002289 Ligand Binding Site [chemical binding]; other site 288681002290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002291 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002292 putative substrate translocation pore; other site 288681002293 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681002294 MarR family; Region: MarR; pfam01047 288681002295 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 288681002296 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 288681002297 active site 288681002298 nucleophile elbow; other site 288681002299 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681002300 short chain dehydrogenase; Provisional; Region: PRK06701 288681002301 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 288681002302 NAD binding site [chemical binding]; other site 288681002303 metal binding site [ion binding]; metal-binding site 288681002304 active site 288681002305 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 288681002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 288681002307 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 288681002308 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681002309 catalytic residues [active] 288681002310 putative disulfide oxidoreductase; Provisional; Region: PRK03113 288681002311 YhdB-like protein; Region: YhdB; pfam14148 288681002312 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 288681002313 Spore germination protein; Region: Spore_permease; cl17796 288681002314 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681002315 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681002316 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681002317 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 288681002318 putative FMN binding site [chemical binding]; other site 288681002319 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 288681002320 SpoVR like protein; Region: SpoVR; pfam04293 288681002321 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 288681002322 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 288681002323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681002324 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681002325 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 288681002326 active site residue [active] 288681002327 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 288681002328 putative homodimer interface [polypeptide binding]; other site 288681002329 putative homotetramer interface [polypeptide binding]; other site 288681002330 putative metal binding site [ion binding]; other site 288681002331 putative homodimer-homodimer interface [polypeptide binding]; other site 288681002332 putative allosteric switch controlling residues; other site 288681002333 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 288681002334 CPxP motif; other site 288681002335 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681002336 active site residue [active] 288681002337 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 288681002338 active site residue [active] 288681002339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681002340 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 288681002341 CPxP motif; other site 288681002342 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681002343 active site residue [active] 288681002344 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681002345 active site residue [active] 288681002346 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 288681002347 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681002348 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681002349 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 288681002350 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 288681002351 NADP binding site [chemical binding]; other site 288681002352 dimer interface [polypeptide binding]; other site 288681002353 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 288681002354 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 288681002355 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 288681002356 PhoU domain; Region: PhoU; pfam01895 288681002357 PhoU domain; Region: PhoU; pfam01895 288681002358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002360 putative substrate translocation pore; other site 288681002361 Uncharacterized conserved protein [Function unknown]; Region: COG3589 288681002362 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 288681002363 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 288681002364 HTH domain; Region: HTH_11; pfam08279 288681002365 Mga helix-turn-helix domain; Region: Mga; pfam05043 288681002366 PRD domain; Region: PRD; pfam00874 288681002367 PRD domain; Region: PRD; pfam00874 288681002368 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 288681002369 active site 288681002370 P-loop; other site 288681002371 phosphorylation site [posttranslational modification] 288681002372 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288681002373 active site 288681002374 phosphorylation site [posttranslational modification] 288681002375 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 288681002376 active site 288681002377 methionine cluster; other site 288681002378 phosphorylation site [posttranslational modification] 288681002379 metal binding site [ion binding]; metal-binding site 288681002380 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681002381 active site 288681002382 P-loop; other site 288681002383 phosphorylation site [posttranslational modification] 288681002384 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 288681002385 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681002386 Uncharacterized conserved protein [Function unknown]; Region: COG3589 288681002387 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 288681002388 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681002389 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681002390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 288681002391 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681002392 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681002393 FtsX-like permease family; Region: FtsX; pfam02687 288681002394 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681002395 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681002396 Walker A/P-loop; other site 288681002397 ATP binding site [chemical binding]; other site 288681002398 Q-loop/lid; other site 288681002399 ABC transporter signature motif; other site 288681002400 Walker B; other site 288681002401 D-loop; other site 288681002402 H-loop/switch region; other site 288681002403 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 288681002404 HlyD family secretion protein; Region: HlyD_3; pfam13437 288681002405 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 288681002406 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 288681002407 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681002408 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681002409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002410 dimer interface [polypeptide binding]; other site 288681002411 conserved gate region; other site 288681002412 ABC-ATPase subunit interface; other site 288681002413 FtsX-like permease family; Region: FtsX; pfam02687 288681002414 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 288681002415 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 288681002416 dimanganese center [ion binding]; other site 288681002417 CotJB protein; Region: CotJB; pfam12652 288681002418 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 288681002419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002420 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681002421 active site 288681002422 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002423 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002424 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 288681002425 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 288681002426 putative DNA binding site [nucleotide binding]; other site 288681002427 putative homodimer interface [polypeptide binding]; other site 288681002428 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 288681002429 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681002430 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288681002431 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 288681002432 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 288681002433 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 288681002434 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681002435 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681002436 active site 288681002437 metal binding site [ion binding]; metal-binding site 288681002438 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681002439 Interdomain contacts; other site 288681002440 Cytokine receptor motif; other site 288681002441 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 288681002442 amino acid transporter; Region: 2A0306; TIGR00909 288681002443 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 288681002444 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 288681002445 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681002446 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 288681002447 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 288681002448 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288681002449 putative active site [active] 288681002450 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 288681002451 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 288681002452 putative active site [active] 288681002453 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 288681002454 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681002455 active site turn [active] 288681002456 phosphorylation site [posttranslational modification] 288681002457 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 288681002458 Probable transposase; Region: OrfB_IS605; pfam01385 288681002459 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681002460 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 288681002461 Uncharacterized conserved protein [Function unknown]; Region: COG3589 288681002462 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 288681002463 DoxX; Region: DoxX; pfam07681 288681002464 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 288681002465 hypothetical protein; Provisional; Region: PRK06770 288681002466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681002467 EamA-like transporter family; Region: EamA; pfam00892 288681002468 EamA-like transporter family; Region: EamA; pfam00892 288681002469 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288681002470 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 288681002471 AsnC family; Region: AsnC_trans_reg; pfam01037 288681002472 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681002473 Coenzyme A binding pocket [chemical binding]; other site 288681002474 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 288681002475 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 288681002476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681002478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002481 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681002482 MarR family; Region: MarR; pfam01047 288681002483 hypothetical protein; Provisional; Region: PRK06847 288681002484 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288681002485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002486 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681002487 putative substrate translocation pore; other site 288681002488 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 288681002489 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 288681002490 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 288681002491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681002493 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 288681002494 Cytochrome P450; Region: p450; cl12078 288681002495 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 288681002496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681002497 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681002498 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 288681002499 putative NAD(P) binding site [chemical binding]; other site 288681002500 catalytic Zn binding site [ion binding]; other site 288681002501 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681002502 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681002503 putative DNA binding site [nucleotide binding]; other site 288681002504 putative Zn2+ binding site [ion binding]; other site 288681002505 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 288681002506 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 288681002507 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 288681002508 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 288681002509 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 288681002510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681002511 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681002512 putative substrate translocation pore; other site 288681002513 intracellular protease, PfpI family; Region: PfpI; TIGR01382 288681002514 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 288681002515 proposed catalytic triad [active] 288681002516 conserved cys residue [active] 288681002517 hydroperoxidase II; Provisional; Region: katE; PRK11249 288681002518 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 288681002519 tetramer interface [polypeptide binding]; other site 288681002520 heme binding pocket [chemical binding]; other site 288681002521 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 288681002522 domain interactions; other site 288681002523 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 288681002524 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 288681002525 Spore germination protein; Region: Spore_permease; cl17796 288681002526 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 288681002527 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 288681002528 tetrameric interface [polypeptide binding]; other site 288681002529 activator binding site; other site 288681002530 NADP binding site [chemical binding]; other site 288681002531 substrate binding site [chemical binding]; other site 288681002532 catalytic residues [active] 288681002533 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681002534 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 288681002535 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681002536 Walker A/P-loop; other site 288681002537 ATP binding site [chemical binding]; other site 288681002538 Q-loop/lid; other site 288681002539 ABC transporter signature motif; other site 288681002540 Walker B; other site 288681002541 D-loop; other site 288681002542 H-loop/switch region; other site 288681002543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681002544 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 288681002545 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681002546 Walker A/P-loop; other site 288681002547 ATP binding site [chemical binding]; other site 288681002548 Q-loop/lid; other site 288681002549 ABC transporter signature motif; other site 288681002550 Walker B; other site 288681002551 D-loop; other site 288681002552 H-loop/switch region; other site 288681002553 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681002554 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681002555 substrate binding pocket [chemical binding]; other site 288681002556 membrane-bound complex binding site; other site 288681002557 hinge residues; other site 288681002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002559 dimer interface [polypeptide binding]; other site 288681002560 conserved gate region; other site 288681002561 putative PBP binding loops; other site 288681002562 ABC-ATPase subunit interface; other site 288681002563 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681002564 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288681002565 Walker A/P-loop; other site 288681002566 ATP binding site [chemical binding]; other site 288681002567 Q-loop/lid; other site 288681002568 ABC transporter signature motif; other site 288681002569 Walker B; other site 288681002570 D-loop; other site 288681002571 H-loop/switch region; other site 288681002572 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681002573 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 288681002574 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 288681002575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 288681002576 hypothetical protein; Provisional; Region: PRK13676 288681002577 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 288681002578 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681002579 Histidine kinase; Region: HisKA_3; pfam07730 288681002580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002581 ATP binding site [chemical binding]; other site 288681002582 Mg2+ binding site [ion binding]; other site 288681002583 G-X-G motif; other site 288681002584 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681002585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002586 active site 288681002587 phosphorylation site [posttranslational modification] 288681002588 intermolecular recognition site; other site 288681002589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681002590 dimerization interface [polypeptide binding]; other site 288681002591 DNA binding residues [nucleotide binding] 288681002592 WxL domain surface cell wall-binding; Region: WxL; pfam13731 288681002593 WxL domain surface cell wall-binding; Region: WxL; pfam13731 288681002594 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 288681002595 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 288681002596 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 288681002597 acetolactate synthase; Reviewed; Region: PRK08617 288681002598 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681002599 PYR/PP interface [polypeptide binding]; other site 288681002600 dimer interface [polypeptide binding]; other site 288681002601 TPP binding site [chemical binding]; other site 288681002602 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681002603 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 288681002604 TPP-binding site [chemical binding]; other site 288681002605 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 288681002606 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 288681002607 active site 288681002608 DNA binding site [nucleotide binding] 288681002609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 288681002610 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681002611 active site 288681002612 motif I; other site 288681002613 motif II; other site 288681002614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681002615 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 288681002616 Cna protein B-type domain; Region: Cna_B; pfam05738 288681002617 Cna protein B-type domain; Region: Cna_B; pfam05738 288681002618 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681002619 amidase catalytic site [active] 288681002620 Zn binding residues [ion binding]; other site 288681002621 substrate binding site [chemical binding]; other site 288681002622 S-layer homology domain; Region: SLH; pfam00395 288681002623 S-layer homology domain; Region: SLH; pfam00395 288681002624 S-layer homology domain; Region: SLH; pfam00395 288681002625 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 288681002626 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 288681002627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681002628 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 288681002629 acyl-activating enzyme (AAE) consensus motif; other site 288681002630 acyl-activating enzyme (AAE) consensus motif; other site 288681002631 putative AMP binding site [chemical binding]; other site 288681002632 putative active site [active] 288681002633 putative CoA binding site [chemical binding]; other site 288681002634 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 288681002635 Sulfate transporter family; Region: Sulfate_transp; pfam00916 288681002636 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 288681002637 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 288681002638 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 288681002639 ATP binding site [chemical binding]; other site 288681002640 putative Mg++ binding site [ion binding]; other site 288681002641 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 288681002642 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681002643 nucleotide binding region [chemical binding]; other site 288681002644 ATP-binding site [chemical binding]; other site 288681002645 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681002646 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 288681002647 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 288681002648 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 288681002649 S-layer homology domain; Region: SLH; pfam00395 288681002650 S-layer homology domain; Region: SLH; pfam00395 288681002651 S-layer homology domain; Region: SLH; pfam00395 288681002652 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 288681002653 S-layer homology domain; Region: SLH; pfam00395 288681002654 S-layer homology domain; Region: SLH; pfam00395 288681002655 S-layer homology domain; Region: SLH; pfam00395 288681002656 DHHW protein; Region: DHHW; pfam14286 288681002657 DHHW protein; Region: DHHW; pfam14286 288681002658 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 288681002659 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 288681002660 enoyl-CoA hydratase; Provisional; Region: PRK07659 288681002661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681002662 substrate binding site [chemical binding]; other site 288681002663 oxyanion hole (OAH) forming residues; other site 288681002664 trimer interface [polypeptide binding]; other site 288681002665 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 288681002666 metal binding site [ion binding]; metal-binding site 288681002667 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 288681002668 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 288681002669 putative oligomer interface [polypeptide binding]; other site 288681002670 putative active site [active] 288681002671 metal binding site [ion binding]; metal-binding site 288681002672 S-layer homology domain; Region: SLH; pfam00395 288681002673 S-layer homology domain; Region: SLH; pfam00395 288681002674 S-layer homology domain; Region: SLH; pfam00395 288681002675 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 288681002676 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681002677 active site 288681002678 metal binding site [ion binding]; metal-binding site 288681002679 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 288681002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681002681 S-adenosylmethionine binding site [chemical binding]; other site 288681002682 proline racemase; Provisional; Region: PRK13969 288681002683 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681002684 ornithine cyclodeaminase; Validated; Region: PRK08618 288681002685 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 288681002686 NAD(P) binding site [chemical binding]; other site 288681002687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288681002688 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 288681002689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681002690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002691 dimer interface [polypeptide binding]; other site 288681002692 conserved gate region; other site 288681002693 putative PBP binding loops; other site 288681002694 ABC-ATPase subunit interface; other site 288681002695 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681002696 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681002697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681002698 dimer interface [polypeptide binding]; other site 288681002699 conserved gate region; other site 288681002700 putative PBP binding loops; other site 288681002701 ABC-ATPase subunit interface; other site 288681002702 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681002703 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681002704 Walker A/P-loop; other site 288681002705 ATP binding site [chemical binding]; other site 288681002706 Q-loop/lid; other site 288681002707 ABC transporter signature motif; other site 288681002708 Walker B; other site 288681002709 D-loop; other site 288681002710 H-loop/switch region; other site 288681002711 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681002712 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 288681002713 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681002714 Walker A/P-loop; other site 288681002715 ATP binding site [chemical binding]; other site 288681002716 Q-loop/lid; other site 288681002717 ABC transporter signature motif; other site 288681002718 Walker B; other site 288681002719 D-loop; other site 288681002720 H-loop/switch region; other site 288681002721 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681002722 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681002723 WYL domain; Region: WYL; pfam13280 288681002724 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288681002725 Dynamin family; Region: Dynamin_N; pfam00350 288681002726 G1 box; other site 288681002727 GTP/Mg2+ binding site [chemical binding]; other site 288681002728 G2 box; other site 288681002729 Switch I region; other site 288681002730 G3 box; other site 288681002731 Switch II region; other site 288681002732 G4 box; other site 288681002733 G5 box; other site 288681002734 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288681002735 Dynamin family; Region: Dynamin_N; pfam00350 288681002736 G1 box; other site 288681002737 GTP/Mg2+ binding site [chemical binding]; other site 288681002738 G2 box; other site 288681002739 Switch I region; other site 288681002740 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288681002741 G3 box; other site 288681002742 Switch II region; other site 288681002743 G4 box; other site 288681002744 G5 box; other site 288681002745 Domain of unknown function DUF87; Region: DUF87; pfam01935 288681002746 AAA-like domain; Region: AAA_10; pfam12846 288681002747 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 288681002748 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 288681002749 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 288681002750 HTH domain; Region: HTH_11; pfam08279 288681002751 WYL domain; Region: WYL; pfam13280 288681002752 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 288681002753 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 288681002754 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 288681002755 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 288681002756 Domain of unknown function DUF87; Region: DUF87; pfam01935 288681002757 AAA-like domain; Region: AAA_10; pfam12846 288681002758 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 288681002759 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 288681002760 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 288681002761 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681002762 catalytic residue [active] 288681002763 DNA sulfur modification protein DndE; Region: DNA_S_dndE; TIGR03184 288681002764 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 288681002765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681002766 Walker A/P-loop; other site 288681002767 ATP binding site [chemical binding]; other site 288681002768 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 288681002769 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 288681002770 Active Sites [active] 288681002771 DNA sulfur modification protein DndB; Region: DNA_S_dndB; TIGR03233 288681002772 DGQHR domain; Region: DGQHR; TIGR03187 288681002773 Tic20-like protein; Region: Tic20; pfam09685 288681002774 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681002775 DNA binding residues [nucleotide binding] 288681002776 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681002777 dimer interface [polypeptide binding]; other site 288681002778 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 288681002779 metal binding site [ion binding]; metal-binding site 288681002780 Helix-turn-helix domain; Region: HTH_36; pfam13730 288681002781 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 288681002782 replicative DNA helicase; Provisional; Region: PRK06749 288681002783 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 288681002784 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 288681002785 Walker A motif; other site 288681002786 ATP binding site [chemical binding]; other site 288681002787 Walker B motif; other site 288681002788 DNA binding loops [nucleotide binding] 288681002789 Predicted transcriptional regulators [Transcription]; Region: COG1378 288681002790 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 288681002791 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 288681002792 C-terminal domain interface [polypeptide binding]; other site 288681002793 sugar binding site [chemical binding]; other site 288681002794 hypothetical protein; Provisional; Region: PRK10621 288681002795 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681002796 Predicted permease; Region: DUF318; cl17795 288681002797 Predicted permease; Region: DUF318; cl17795 288681002798 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681002799 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681002800 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 288681002801 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681002802 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 288681002803 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 288681002804 CGNR zinc finger; Region: zf-CGNR; pfam11706 288681002805 HPP family; Region: HPP; pfam04982 288681002806 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 288681002807 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681002808 putative NAD(P) binding site [chemical binding]; other site 288681002809 active site 288681002810 putative substrate binding site [chemical binding]; other site 288681002811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681002812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681002813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681002814 YmzC-like protein; Region: YmzC; pfam14157 288681002815 transcriptional antiterminator BglG; Provisional; Region: PRK09772 288681002816 CAT RNA binding domain; Region: CAT_RBD; smart01061 288681002817 PRD domain; Region: PRD; pfam00874 288681002818 PRD domain; Region: PRD; pfam00874 288681002819 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 288681002820 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681002821 active site turn [active] 288681002822 phosphorylation site [posttranslational modification] 288681002823 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 288681002824 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 288681002825 HPr interaction site; other site 288681002826 glycerol kinase (GK) interaction site [polypeptide binding]; other site 288681002827 active site 288681002828 phosphorylation site [posttranslational modification] 288681002829 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 288681002830 beta-galactosidase; Region: BGL; TIGR03356 288681002831 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681002832 MarR family; Region: MarR_2; pfam12802 288681002833 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 288681002834 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 288681002835 ATP synthase I chain; Region: ATP_synt_I; pfam03899 288681002836 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 288681002837 VanZ like family; Region: VanZ; pfam04892 288681002838 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 288681002839 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 288681002840 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 288681002841 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 288681002842 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 288681002843 dihydroxyacetone kinase; Provisional; Region: PRK14479 288681002844 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 288681002845 DAK2 domain; Region: Dak2; pfam02734 288681002846 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 288681002847 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681002848 Transcriptional regulator; Region: Rrf2; pfam02082 288681002849 DAK2 domain; Region: Dak2; pfam02734 288681002850 Bacterial SH3 domain; Region: SH3_3; cl17532 288681002851 CAAX protease self-immunity; Region: Abi; pfam02517 288681002852 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 288681002853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681002854 Zn2+ binding site [ion binding]; other site 288681002855 Mg2+ binding site [ion binding]; other site 288681002856 S-layer homology domain; Region: SLH; pfam00395 288681002857 S-layer homology domain; Region: SLH; pfam00395 288681002858 S-layer homology domain; Region: SLH; pfam00395 288681002859 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 288681002860 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681002861 Transcriptional regulator PadR-like family; Region: PadR; cl17335 288681002862 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 288681002863 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 288681002864 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681002866 active site 288681002867 Heat induced stress protein YflT; Region: YflT; pfam11181 288681002868 CsbD-like; Region: CsbD; pfam05532 288681002869 Predicted membrane protein [Function unknown]; Region: COG2261 288681002870 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 288681002871 anti sigma factor interaction site; other site 288681002872 regulatory phosphorylation site [posttranslational modification]; other site 288681002873 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 288681002874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002875 ATP binding site [chemical binding]; other site 288681002876 Mg2+ binding site [ion binding]; other site 288681002877 G-X-G motif; other site 288681002878 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 288681002879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681002880 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681002881 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681002882 DNA binding residues [nucleotide binding] 288681002883 Ferritin-like domain; Region: Ferritin; pfam00210 288681002884 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 288681002885 dinuclear metal binding motif [ion binding]; other site 288681002886 Response regulator receiver domain; Region: Response_reg; pfam00072 288681002887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002888 active site 288681002889 phosphorylation site [posttranslational modification] 288681002890 intermolecular recognition site; other site 288681002891 dimerization interface [polypeptide binding]; other site 288681002892 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 288681002893 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 288681002894 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 288681002895 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 288681002896 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 288681002897 CHASE3 domain; Region: CHASE3; pfam05227 288681002898 GAF domain; Region: GAF; pfam01590 288681002899 GAF domain; Region: GAF_2; pfam13185 288681002900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681002901 dimer interface [polypeptide binding]; other site 288681002902 phosphorylation site [posttranslational modification] 288681002903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002904 ATP binding site [chemical binding]; other site 288681002905 Mg2+ binding site [ion binding]; other site 288681002906 G-X-G motif; other site 288681002907 Response regulator receiver domain; Region: Response_reg; pfam00072 288681002908 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002909 active site 288681002910 phosphorylation site [posttranslational modification] 288681002911 intermolecular recognition site; other site 288681002912 dimerization interface [polypeptide binding]; other site 288681002913 regulatory protein interface [polypeptide binding]; other site 288681002914 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 288681002915 regulatory phosphorylation site [posttranslational modification]; other site 288681002916 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 288681002917 hypothetical protein; Provisional; Region: PRK12856 288681002918 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681002919 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681002920 active site 288681002921 phosphorylation site [posttranslational modification] 288681002922 intermolecular recognition site; other site 288681002923 dimerization interface [polypeptide binding]; other site 288681002924 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681002925 DNA binding site [nucleotide binding] 288681002926 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681002927 HAMP domain; Region: HAMP; pfam00672 288681002928 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681002929 dimer interface [polypeptide binding]; other site 288681002930 phosphorylation site [posttranslational modification] 288681002931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681002932 ATP binding site [chemical binding]; other site 288681002933 Mg2+ binding site [ion binding]; other site 288681002934 G-X-G motif; other site 288681002935 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681002936 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681002937 Walker A/P-loop; other site 288681002938 ATP binding site [chemical binding]; other site 288681002939 Q-loop/lid; other site 288681002940 ABC transporter signature motif; other site 288681002941 Walker B; other site 288681002942 D-loop; other site 288681002943 H-loop/switch region; other site 288681002944 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681002945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 288681002946 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 288681002947 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681002948 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681002949 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 288681002950 NADP binding site [chemical binding]; other site 288681002951 dimer interface [polypeptide binding]; other site 288681002952 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 288681002953 YhzD-like protein; Region: YhzD; pfam14120 288681002954 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 288681002955 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681002956 active site 288681002957 metal binding site [ion binding]; metal-binding site 288681002958 DNA binding site [nucleotide binding] 288681002959 AAA domain; Region: AAA_27; pfam13514 288681002960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681002961 Q-loop/lid; other site 288681002962 ABC transporter signature motif; other site 288681002963 Walker B; other site 288681002964 D-loop; other site 288681002965 H-loop/switch region; other site 288681002966 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 288681002967 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 288681002968 generic binding surface I; other site 288681002969 generic binding surface II; other site 288681002970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681002971 Zn2+ binding site [ion binding]; other site 288681002972 Mg2+ binding site [ion binding]; other site 288681002973 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681002974 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 288681002975 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 288681002976 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681002977 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 288681002978 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681002979 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002980 Zn binding site [ion binding]; other site 288681002981 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681002982 Zn binding site [ion binding]; other site 288681002983 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681002984 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681002985 Zn binding site [ion binding]; other site 288681002986 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681002987 Zn binding site [ion binding]; other site 288681002988 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681002989 TPR motif; other site 288681002990 binding surface 288681002991 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681002992 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 288681002993 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 288681002994 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002995 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 288681002996 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 288681002997 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 288681002998 amphipathic channel; other site 288681002999 Asn-Pro-Ala signature motifs; other site 288681003000 glycerol kinase; Provisional; Region: glpK; PRK00047 288681003001 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 288681003002 N- and C-terminal domain interface [polypeptide binding]; other site 288681003003 active site 288681003004 MgATP binding site [chemical binding]; other site 288681003005 catalytic site [active] 288681003006 metal binding site [ion binding]; metal-binding site 288681003007 glycerol binding site [chemical binding]; other site 288681003008 homotetramer interface [polypeptide binding]; other site 288681003009 homodimer interface [polypeptide binding]; other site 288681003010 FBP binding site [chemical binding]; other site 288681003011 protein IIAGlc interface [polypeptide binding]; other site 288681003012 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 288681003013 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 288681003014 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681003015 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681003016 DNA binding residues [nucleotide binding] 288681003017 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 288681003018 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681003019 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 288681003020 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681003021 MarR family; Region: MarR; pfam01047 288681003022 DoxX-like family; Region: DoxX_2; pfam13564 288681003023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681003024 putative substrate translocation pore; other site 288681003025 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681003026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681003027 putative substrate translocation pore; other site 288681003028 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 288681003029 Part of AAA domain; Region: AAA_19; pfam13245 288681003030 Family description; Region: UvrD_C_2; pfam13538 288681003031 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 288681003032 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 288681003033 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 288681003034 transcriptional regulator Hpr; Provisional; Region: PRK13777 288681003035 MarR family; Region: MarR; pfam01047 288681003036 YtxH-like protein; Region: YtxH; cl02079 288681003037 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 288681003038 HIT family signature motif; other site 288681003039 catalytic residue [active] 288681003040 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681003041 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681003042 Walker A/P-loop; other site 288681003043 ATP binding site [chemical binding]; other site 288681003044 Q-loop/lid; other site 288681003045 ABC transporter signature motif; other site 288681003046 Walker B; other site 288681003047 D-loop; other site 288681003048 H-loop/switch region; other site 288681003049 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 288681003050 EcsC protein family; Region: EcsC; pfam12787 288681003051 Protein of unknown function (DUF1433); Region: DUF1433; pfam07252 288681003052 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 288681003053 nucleophilic elbow; other site 288681003054 catalytic triad; other site 288681003055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681003056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681003057 Uncharacterized conserved protein [Function unknown]; Region: COG3402 288681003058 Predicted membrane protein [Function unknown]; Region: COG3428 288681003059 Bacterial PH domain; Region: DUF304; pfam03703 288681003060 Bacterial PH domain; Region: DUF304; cl01348 288681003061 Bacterial PH domain; Region: DUF304; pfam03703 288681003062 S-layer homology domain; Region: SLH; pfam00395 288681003063 S-layer homology domain; Region: SLH; pfam00395 288681003064 S-layer homology domain; Region: SLH; pfam00395 288681003065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 288681003066 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 288681003067 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 288681003068 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 288681003069 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681003070 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681003071 DNA binding residues [nucleotide binding] 288681003072 drug binding residues [chemical binding]; other site 288681003073 dimer interface [polypeptide binding]; other site 288681003074 Uncharacterized conserved protein [Function unknown]; Region: COG3402 288681003075 Predicted membrane protein [Function unknown]; Region: COG3428 288681003076 Bacterial PH domain; Region: DUF304; pfam03703 288681003077 Bacterial PH domain; Region: DUF304; pfam03703 288681003078 Bacterial PH domain; Region: DUF304; pfam03703 288681003079 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 288681003080 Transglycosylase; Region: Transgly; pfam00912 288681003081 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681003082 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681003083 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 288681003084 substrate binding site [chemical binding]; other site 288681003085 active site 288681003086 ferrochelatase; Provisional; Region: PRK12435 288681003087 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 288681003088 C-terminal domain interface [polypeptide binding]; other site 288681003089 active site 288681003090 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 288681003091 active site 288681003092 N-terminal domain interface [polypeptide binding]; other site 288681003093 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 288681003094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681003095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 288681003096 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 288681003097 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 288681003098 Fn3 associated; Region: Fn3_assoc; pfam13287 288681003099 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 288681003100 generic binding surface II; other site 288681003101 generic binding surface I; other site 288681003102 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 288681003103 putative active site [active] 288681003104 putative catalytic site [active] 288681003105 putative Mg binding site IVb [ion binding]; other site 288681003106 putative phosphate binding site [ion binding]; other site 288681003107 putative DNA binding site [nucleotide binding]; other site 288681003108 putative Mg binding site IVa [ion binding]; other site 288681003109 Penicillinase repressor; Region: Pencillinase_R; pfam03965 288681003110 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 288681003111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681003112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681003113 Predicted membrane protein [Function unknown]; Region: COG1511 288681003114 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681003115 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 288681003116 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 288681003117 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681003118 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 288681003119 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681003120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681003121 Coenzyme A binding pocket [chemical binding]; other site 288681003122 DinB superfamily; Region: DinB_2; pfam12867 288681003123 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 288681003124 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681003125 HTH domain; Region: HTH_11; pfam08279 288681003126 WYL domain; Region: WYL; pfam13280 288681003127 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681003128 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681003129 DNA binding site [nucleotide binding] 288681003130 domain linker motif; other site 288681003131 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681003132 putative dimerization interface [polypeptide binding]; other site 288681003133 putative ligand binding site [chemical binding]; other site 288681003134 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 288681003135 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288681003136 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 288681003137 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 288681003138 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 288681003139 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 288681003140 acyl-activating enzyme (AAE) consensus motif; other site 288681003141 putative AMP binding site [chemical binding]; other site 288681003142 putative active site [active] 288681003143 putative CoA binding site [chemical binding]; other site 288681003144 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 288681003145 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681003146 heme-binding site [chemical binding]; other site 288681003147 S-layer homology domain; Region: SLH; pfam00395 288681003148 S-layer homology domain; Region: SLH; pfam00395 288681003149 S-layer homology domain; Region: SLH; pfam00395 288681003150 Leukocidin/Hemolysin toxin family; Region: Leukocidin; pfam07968 288681003151 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681003152 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681003153 putative active site [active] 288681003154 putative metal binding site [ion binding]; other site 288681003155 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681003156 Zn2+ binding site [ion binding]; other site 288681003157 Mg2+ binding site [ion binding]; other site 288681003158 Putative zinc-finger; Region: zf-HC2; pfam13490 288681003159 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 288681003160 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 288681003161 RNA polymerase sigma factor; Provisional; Region: PRK12541 288681003162 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681003163 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681003164 DNA binding residues [nucleotide binding] 288681003165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681003166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681003167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681003168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 288681003169 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681003170 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681003171 active site 288681003172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681003173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003174 dimer interface [polypeptide binding]; other site 288681003175 phosphorylation site [posttranslational modification] 288681003176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003177 ATP binding site [chemical binding]; other site 288681003178 Mg2+ binding site [ion binding]; other site 288681003179 G-X-G motif; other site 288681003180 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681003181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681003182 active site 288681003183 phosphorylation site [posttranslational modification] 288681003184 intermolecular recognition site; other site 288681003185 dimerization interface [polypeptide binding]; other site 288681003186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681003187 DNA binding site [nucleotide binding] 288681003188 CAAX protease self-immunity; Region: Abi; pfam02517 288681003189 Peptidase family M48; Region: Peptidase_M48; pfam01435 288681003190 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681003191 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681003192 dimerization interface [polypeptide binding]; other site 288681003193 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681003194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681003195 dimer interface [polypeptide binding]; other site 288681003196 putative CheW interface [polypeptide binding]; other site 288681003197 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681003198 EamA-like transporter family; Region: EamA; pfam00892 288681003199 EamA-like transporter family; Region: EamA; pfam00892 288681003200 S-layer homology domain; Region: SLH; pfam00395 288681003201 S-layer homology domain; Region: SLH; pfam00395 288681003202 S-layer homology domain; Region: SLH; pfam00395 288681003203 S-layer homology domain; Region: SLH; pfam00395 288681003204 S-layer homology domain; Region: SLH; pfam00395 288681003205 S-layer homology domain; Region: SLH; pfam00395 288681003206 S-layer homology domain; Region: SLH; pfam00395 288681003207 S-layer homology domain; Region: SLH; pfam00395 288681003208 S-layer homology domain; Region: SLH; pfam00395 288681003209 malate synthase A; Region: malate_syn_A; TIGR01344 288681003210 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 288681003211 active site 288681003212 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288681003213 tetramer interface [polypeptide binding]; other site 288681003214 active site 288681003215 Mg2+/Mn2+ binding site [ion binding]; other site 288681003216 Phosphotransferase enzyme family; Region: APH; pfam01636 288681003217 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 288681003218 active site 288681003219 substrate binding site [chemical binding]; other site 288681003220 ATP binding site [chemical binding]; other site 288681003221 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288681003222 DNA-binding site [nucleotide binding]; DNA binding site 288681003223 RNA-binding motif; other site 288681003224 ComK protein; Region: ComK; pfam06338 288681003225 Uncharacterized conserved protein [Function unknown]; Region: COG0398 288681003226 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681003227 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681003228 Catalytic site [active] 288681003229 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 288681003230 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 288681003231 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 288681003232 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 288681003233 Part of AAA domain; Region: AAA_19; pfam13245 288681003234 Family description; Region: UvrD_C_2; pfam13538 288681003235 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 288681003236 hypothetical protein; Provisional; Region: PRK07758 288681003237 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681003238 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 288681003239 Spore germination protein GerPC; Region: GerPC; pfam10737 288681003240 Spore germination GerPB; Region: GerPB; pfam10803 288681003241 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681003242 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681003243 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 288681003244 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 288681003245 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681003246 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 288681003247 inhibitor-cofactor binding pocket; inhibition site 288681003248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681003249 catalytic residue [active] 288681003250 hypothetical protein; Provisional; Region: PRK13673 288681003251 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 288681003252 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 288681003253 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288681003254 dimer interface [polypeptide binding]; other site 288681003255 active site 288681003256 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288681003257 Ligand Binding Site [chemical binding]; other site 288681003258 Molecular Tunnel; other site 288681003259 ferrochelatase; Provisional; Region: PRK12435 288681003260 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 288681003261 C-terminal domain interface [polypeptide binding]; other site 288681003262 active site 288681003263 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 288681003264 active site 288681003265 N-terminal domain interface [polypeptide binding]; other site 288681003266 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288681003267 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 288681003268 tetramer interface [polypeptide binding]; other site 288681003269 heme binding pocket [chemical binding]; other site 288681003270 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 288681003271 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 288681003272 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 288681003273 active site 288681003274 catalytic site [active] 288681003275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681003276 non-specific DNA binding site [nucleotide binding]; other site 288681003277 salt bridge; other site 288681003278 sequence-specific DNA binding site [nucleotide binding]; other site 288681003279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681003280 binding surface 288681003281 TPR motif; other site 288681003282 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681003283 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 288681003284 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 288681003285 S1 domain; Region: S1_2; pfam13509 288681003286 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 288681003287 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 288681003288 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681003289 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681003290 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681003291 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681003292 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 288681003293 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681003294 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681003295 active site 288681003296 motif I; other site 288681003297 motif II; other site 288681003298 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288681003299 YjzC-like protein; Region: YjzC; pfam14168 288681003300 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 288681003301 Clp amino terminal domain; Region: Clp_N; pfam02861 288681003302 Clp amino terminal domain; Region: Clp_N; pfam02861 288681003303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681003304 Walker A motif; other site 288681003305 ATP binding site [chemical binding]; other site 288681003306 Walker B motif; other site 288681003307 arginine finger; other site 288681003308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681003309 Walker A motif; other site 288681003310 ATP binding site [chemical binding]; other site 288681003311 Walker B motif; other site 288681003312 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 288681003313 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 288681003314 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 288681003315 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 288681003316 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681003317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681003318 NAD(P) binding site [chemical binding]; other site 288681003319 active site 288681003320 ComZ; Region: ComZ; pfam10815 288681003321 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 288681003322 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681003323 dimer interface [polypeptide binding]; other site 288681003324 active site 288681003325 CoA binding pocket [chemical binding]; other site 288681003326 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 288681003327 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 288681003328 dimer interface [polypeptide binding]; other site 288681003329 active site 288681003330 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 288681003331 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 288681003332 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 288681003333 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 288681003334 active site 288681003335 HIGH motif; other site 288681003336 dimer interface [polypeptide binding]; other site 288681003337 KMSKS motif; other site 288681003338 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 288681003339 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681003340 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681003341 peptide binding site [polypeptide binding]; other site 288681003342 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681003343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003344 dimer interface [polypeptide binding]; other site 288681003345 conserved gate region; other site 288681003346 putative PBP binding loops; other site 288681003347 ABC-ATPase subunit interface; other site 288681003348 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681003349 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681003350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003351 dimer interface [polypeptide binding]; other site 288681003352 conserved gate region; other site 288681003353 putative PBP binding loops; other site 288681003354 ABC-ATPase subunit interface; other site 288681003355 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681003356 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681003357 Walker A/P-loop; other site 288681003358 ATP binding site [chemical binding]; other site 288681003359 Q-loop/lid; other site 288681003360 ABC transporter signature motif; other site 288681003361 Walker B; other site 288681003362 D-loop; other site 288681003363 H-loop/switch region; other site 288681003364 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681003365 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 288681003366 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681003367 Walker A/P-loop; other site 288681003368 ATP binding site [chemical binding]; other site 288681003369 Q-loop/lid; other site 288681003370 ABC transporter signature motif; other site 288681003371 Walker B; other site 288681003372 D-loop; other site 288681003373 H-loop/switch region; other site 288681003374 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 288681003375 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288681003376 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 288681003377 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681003378 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681003379 peptide binding site [polypeptide binding]; other site 288681003380 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 288681003381 putative catalytic residues [active] 288681003382 thiol/disulfide switch; other site 288681003383 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 288681003384 adaptor protein; Provisional; Region: PRK02315 288681003385 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 288681003386 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 288681003387 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681003388 putative active site [active] 288681003389 catalytic site [active] 288681003390 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681003391 putative active site [active] 288681003392 catalytic site [active] 288681003393 Competence protein CoiA-like family; Region: CoiA; cl11541 288681003394 oligoendopeptidase F; Region: pepF; TIGR00181 288681003395 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 288681003396 active site 288681003397 Zn binding site [ion binding]; other site 288681003398 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 288681003399 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 288681003400 catalytic residues [active] 288681003401 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 288681003402 apolar tunnel; other site 288681003403 heme binding site [chemical binding]; other site 288681003404 dimerization interface [polypeptide binding]; other site 288681003405 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 288681003406 putative active site [active] 288681003407 putative metal binding residues [ion binding]; other site 288681003408 signature motif; other site 288681003409 putative triphosphate binding site [ion binding]; other site 288681003410 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288681003411 synthetase active site [active] 288681003412 NTP binding site [chemical binding]; other site 288681003413 metal binding site [ion binding]; metal-binding site 288681003414 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 288681003415 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 288681003416 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288681003417 active site 288681003418 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 288681003419 trimer interface [polypeptide binding]; other site 288681003420 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 288681003421 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 288681003422 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 288681003423 active site 288681003424 metal binding site [ion binding]; metal-binding site 288681003425 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 288681003426 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681003427 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 288681003428 active site 288681003429 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681003430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003431 S-adenosylmethionine binding site [chemical binding]; other site 288681003432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288681003433 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 288681003434 putative metal binding site; other site 288681003435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681003436 binding surface 288681003437 TPR motif; other site 288681003438 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681003439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003440 S-adenosylmethionine binding site [chemical binding]; other site 288681003441 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 288681003442 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 288681003443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681003444 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 288681003445 active site 288681003446 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 288681003447 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 288681003448 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 288681003449 NAD binding site [chemical binding]; other site 288681003450 substrate binding site [chemical binding]; other site 288681003451 homodimer interface [polypeptide binding]; other site 288681003452 active site 288681003453 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 288681003454 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 288681003455 NADP binding site [chemical binding]; other site 288681003456 active site 288681003457 putative substrate binding site [chemical binding]; other site 288681003458 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 288681003459 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 288681003460 NAD binding site [chemical binding]; other site 288681003461 homotetramer interface [polypeptide binding]; other site 288681003462 homodimer interface [polypeptide binding]; other site 288681003463 substrate binding site [chemical binding]; other site 288681003464 active site 288681003465 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 288681003466 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 288681003467 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 288681003468 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 288681003469 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 288681003470 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 288681003471 Part of AAA domain; Region: AAA_19; pfam13245 288681003472 Family description; Region: UvrD_C_2; pfam13538 288681003473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 288681003474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681003475 Coenzyme A binding pocket [chemical binding]; other site 288681003476 hypothetical protein; Provisional; Region: PRK13679 288681003477 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288681003478 Putative esterase; Region: Esterase; pfam00756 288681003479 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 288681003480 EamA-like transporter family; Region: EamA; pfam00892 288681003481 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681003482 EamA-like transporter family; Region: EamA; pfam00892 288681003483 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681003484 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 288681003485 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 288681003486 Na binding site [ion binding]; other site 288681003487 anthranilate synthase component I; Provisional; Region: PRK13570 288681003488 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 288681003489 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 288681003490 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 288681003491 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 288681003492 glutamine binding [chemical binding]; other site 288681003493 catalytic triad [active] 288681003494 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 288681003495 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288681003496 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288681003497 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 288681003498 active site 288681003499 ribulose/triose binding site [chemical binding]; other site 288681003500 phosphate binding site [ion binding]; other site 288681003501 substrate (anthranilate) binding pocket [chemical binding]; other site 288681003502 product (indole) binding pocket [chemical binding]; other site 288681003503 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 288681003504 active site 288681003505 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 288681003506 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 288681003507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681003508 catalytic residue [active] 288681003509 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 288681003510 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 288681003511 substrate binding site [chemical binding]; other site 288681003512 active site 288681003513 catalytic residues [active] 288681003514 heterodimer interface [polypeptide binding]; other site 288681003515 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 288681003516 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 288681003517 L-lactate permease; Region: Lactate_perm; cl00701 288681003518 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 288681003519 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 288681003520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681003521 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 288681003522 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681003523 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681003524 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681003525 Coenzyme A binding pocket [chemical binding]; other site 288681003526 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 288681003527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003528 S-adenosylmethionine binding site [chemical binding]; other site 288681003529 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288681003530 NADPH bind site [chemical binding]; other site 288681003531 putative FMN binding site [chemical binding]; other site 288681003532 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288681003533 putative FMN binding site [chemical binding]; other site 288681003534 NADPH bind site [chemical binding]; other site 288681003535 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 288681003536 YcaO-like family; Region: YcaO; pfam02624 288681003537 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 288681003538 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 288681003539 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 288681003540 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 288681003541 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681003542 E3 interaction surface; other site 288681003543 lipoyl attachment site [posttranslational modification]; other site 288681003544 e3 binding domain; Region: E3_binding; pfam02817 288681003545 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288681003546 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 288681003547 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 288681003548 TPP-binding site [chemical binding]; other site 288681003549 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 288681003550 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681003551 salt bridge; other site 288681003552 non-specific DNA binding site [nucleotide binding]; other site 288681003553 sequence-specific DNA binding site [nucleotide binding]; other site 288681003554 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 288681003555 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681003556 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 288681003557 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 288681003558 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 288681003559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681003560 S-adenosylmethionine binding site [chemical binding]; other site 288681003561 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681003562 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681003563 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 288681003564 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681003565 Catalytic site [active] 288681003566 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681003567 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 288681003568 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 288681003569 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681003570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681003571 non-specific DNA binding site [nucleotide binding]; other site 288681003572 salt bridge; other site 288681003573 sequence-specific DNA binding site [nucleotide binding]; other site 288681003574 Anti-repressor SinI; Region: SinI; pfam08671 288681003575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 288681003576 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 288681003577 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 288681003578 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 288681003579 NAD(P) binding site [chemical binding]; other site 288681003580 catalytic residues [active] 288681003581 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 288681003582 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 288681003583 Walker A/P-loop; other site 288681003584 ATP binding site [chemical binding]; other site 288681003585 Q-loop/lid; other site 288681003586 ABC transporter signature motif; other site 288681003587 Walker B; other site 288681003588 D-loop; other site 288681003589 H-loop/switch region; other site 288681003590 TOBE domain; Region: TOBE_2; pfam08402 288681003591 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 288681003592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003593 dimer interface [polypeptide binding]; other site 288681003594 conserved gate region; other site 288681003595 putative PBP binding loops; other site 288681003596 ABC-ATPase subunit interface; other site 288681003597 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 288681003598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003599 dimer interface [polypeptide binding]; other site 288681003600 conserved gate region; other site 288681003601 putative PBP binding loops; other site 288681003602 ABC-ATPase subunit interface; other site 288681003603 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 288681003604 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 288681003605 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 288681003606 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 288681003607 active site 288681003608 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 288681003609 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 288681003610 ABC-2 type transporter; Region: ABC2_membrane; cl17235 288681003611 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 288681003612 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288681003613 active site 288681003614 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288681003615 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 288681003616 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 288681003617 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681003618 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 288681003619 Cysteine-rich domain; Region: CCG; pfam02754 288681003620 Cysteine-rich domain; Region: CCG; pfam02754 288681003621 FAD binding domain; Region: FAD_binding_4; pfam01565 288681003622 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 288681003623 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 288681003624 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 288681003625 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288681003626 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 288681003627 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 288681003628 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681003629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681003630 active site 288681003631 phosphorylation site [posttranslational modification] 288681003632 intermolecular recognition site; other site 288681003633 dimerization interface [polypeptide binding]; other site 288681003634 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681003635 DNA binding site [nucleotide binding] 288681003636 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681003637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681003638 dimerization interface [polypeptide binding]; other site 288681003639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003640 dimer interface [polypeptide binding]; other site 288681003641 phosphorylation site [posttranslational modification] 288681003642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003643 ATP binding site [chemical binding]; other site 288681003644 Mg2+ binding site [ion binding]; other site 288681003645 G-X-G motif; other site 288681003646 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288681003647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681003648 DNA-binding site [nucleotide binding]; DNA binding site 288681003649 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 288681003650 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 288681003651 Cysteine-rich domain; Region: CCG; pfam02754 288681003652 Cysteine-rich domain; Region: CCG; pfam02754 288681003653 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 288681003654 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 288681003655 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 288681003656 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 288681003657 Uncharacterized conserved protein [Function unknown]; Region: COG1556 288681003658 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 288681003659 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 288681003660 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 288681003661 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 288681003662 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 288681003663 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 288681003664 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288681003665 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681003666 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 288681003667 dimer interaction site [polypeptide binding]; other site 288681003668 substrate-binding tunnel; other site 288681003669 active site 288681003670 catalytic site [active] 288681003671 substrate binding site [chemical binding]; other site 288681003672 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 288681003673 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 288681003674 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681003675 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 288681003676 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 288681003677 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 288681003678 NAD(P) binding site [chemical binding]; other site 288681003679 active site 288681003680 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 288681003681 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 288681003682 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 288681003683 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 288681003684 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681003685 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 288681003686 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288681003687 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 288681003688 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 288681003689 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 288681003690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681003691 Walker A/P-loop; other site 288681003692 ATP binding site [chemical binding]; other site 288681003693 Q-loop/lid; other site 288681003694 ABC transporter signature motif; other site 288681003695 Walker B; other site 288681003696 D-loop; other site 288681003697 H-loop/switch region; other site 288681003698 TOBE domain; Region: TOBE_2; pfam08402 288681003699 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 288681003700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003701 dimer interface [polypeptide binding]; other site 288681003702 conserved gate region; other site 288681003703 putative PBP binding loops; other site 288681003704 ABC-ATPase subunit interface; other site 288681003705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681003706 dimer interface [polypeptide binding]; other site 288681003707 conserved gate region; other site 288681003708 putative PBP binding loops; other site 288681003709 ABC-ATPase subunit interface; other site 288681003710 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 288681003711 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681003712 motif II; other site 288681003713 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 288681003714 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681003715 catalytic residue [active] 288681003716 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 288681003717 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681003718 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 288681003719 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288681003720 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681003721 heme-binding site [chemical binding]; other site 288681003722 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003723 Leucine rich repeat; Region: LRR_8; pfam13855 288681003724 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 288681003725 Leucine rich repeat; Region: LRR_8; pfam13855 288681003726 Leucine-rich repeats; other site 288681003727 Substrate binding site [chemical binding]; other site 288681003728 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003729 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003730 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 288681003731 Leucine rich repeat; Region: LRR_8; pfam13855 288681003732 S-layer homology domain; Region: SLH; pfam00395 288681003733 S-layer homology domain; Region: SLH; pfam00395 288681003734 S-layer homology domain; Region: SLH; pfam00395 288681003735 hypothetical protein; Validated; Region: PRK06755 288681003736 intersubunit interface [polypeptide binding]; other site 288681003737 active site 288681003738 Zn2+ binding site [ion binding]; other site 288681003739 FOG: CBS domain [General function prediction only]; Region: COG0517 288681003740 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 288681003741 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 288681003742 NodB motif; other site 288681003743 putative active site [active] 288681003744 putative catalytic site [active] 288681003745 Zn binding site [ion binding]; other site 288681003746 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681003747 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 288681003748 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003749 dimer interface [polypeptide binding]; other site 288681003750 phosphorylation site [posttranslational modification] 288681003751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003752 ATP binding site [chemical binding]; other site 288681003753 Mg2+ binding site [ion binding]; other site 288681003754 G-X-G motif; other site 288681003755 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681003756 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681003757 dimerization interface [polypeptide binding]; other site 288681003758 putative DNA binding site [nucleotide binding]; other site 288681003759 putative Zn2+ binding site [ion binding]; other site 288681003760 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 288681003761 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 288681003762 active site 288681003763 Zn binding site [ion binding]; other site 288681003764 DinB superfamily; Region: DinB_2; pfam12867 288681003765 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 288681003766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681003767 dimer interface [polypeptide binding]; other site 288681003768 phosphorylation site [posttranslational modification] 288681003769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681003770 ATP binding site [chemical binding]; other site 288681003771 Mg2+ binding site [ion binding]; other site 288681003772 G-X-G motif; other site 288681003773 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 288681003774 Ligand Binding Site [chemical binding]; other site 288681003775 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 288681003776 active site 288681003777 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 288681003778 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 288681003779 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 288681003780 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 288681003781 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 288681003782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681003783 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681003784 Coenzyme A binding pocket [chemical binding]; other site 288681003785 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 288681003786 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 288681003787 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 288681003788 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 288681003789 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 288681003790 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 288681003791 dimer interface [polypeptide binding]; other site 288681003792 putative radical transfer pathway; other site 288681003793 diiron center [ion binding]; other site 288681003794 tyrosyl radical; other site 288681003795 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681003796 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681003797 DNA-binding site [nucleotide binding]; DNA binding site 288681003798 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681003799 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681003800 Walker A/P-loop; other site 288681003801 ATP binding site [chemical binding]; other site 288681003802 Q-loop/lid; other site 288681003803 ABC transporter signature motif; other site 288681003804 Walker B; other site 288681003805 D-loop; other site 288681003806 H-loop/switch region; other site 288681003807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681003808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681003809 Walker A/P-loop; other site 288681003810 ATP binding site [chemical binding]; other site 288681003811 Q-loop/lid; other site 288681003812 ABC transporter signature motif; other site 288681003813 Walker B; other site 288681003814 D-loop; other site 288681003815 H-loop/switch region; other site 288681003816 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 288681003817 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681003818 CAAX protease self-immunity; Region: Abi; pfam02517 288681003819 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 288681003820 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 288681003821 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288681003822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681003823 putative DNA binding site [nucleotide binding]; other site 288681003824 putative Zn2+ binding site [ion binding]; other site 288681003825 AsnC family; Region: AsnC_trans_reg; pfam01037 288681003826 Uncharacterized conserved protein [Function unknown]; Region: COG2128 288681003827 Isochorismatase family; Region: Isochorismatase; pfam00857 288681003828 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681003829 catalytic triad [active] 288681003830 conserved cis-peptide bond; other site 288681003831 SseB protein; Region: SseB; cl06279 288681003832 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 288681003833 dimer interface [polypeptide binding]; other site 288681003834 catalytic triad [active] 288681003835 Nitronate monooxygenase; Region: NMO; pfam03060 288681003836 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 288681003837 FMN binding site [chemical binding]; other site 288681003838 substrate binding site [chemical binding]; other site 288681003839 putative catalytic residue [active] 288681003840 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 288681003841 DltD N-terminal region; Region: DltD_N; pfam04915 288681003842 DltD central region; Region: DltD_M; pfam04918 288681003843 DltD C-terminal region; Region: DltD_C; pfam04914 288681003844 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 288681003845 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 288681003846 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 288681003847 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 288681003848 acyl-activating enzyme (AAE) consensus motif; other site 288681003849 AMP binding site [chemical binding]; other site 288681003850 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 288681003851 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681003852 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 288681003853 metal binding site [ion binding]; metal-binding site 288681003854 dimer interface [polypeptide binding]; other site 288681003855 flavodoxin; Provisional; Region: PRK06756 288681003856 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 288681003857 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681003858 Phosphotransferase enzyme family; Region: APH; pfam01636 288681003859 active site 288681003860 substrate binding site [chemical binding]; other site 288681003861 ATP binding site [chemical binding]; other site 288681003862 multidrug efflux protein; Reviewed; Region: PRK01766 288681003863 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 288681003864 cation binding site [ion binding]; other site 288681003865 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 288681003866 Thioredoxin; Region: Thioredoxin_9; pfam14595 288681003867 Regulatory protein YrvL; Region: YrvL; pfam14184 288681003868 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681003869 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681003870 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681003871 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 288681003872 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 288681003873 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 288681003874 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 288681003875 hypothetical protein; Provisional; Region: PRK03094 288681003876 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 288681003877 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681003878 homodimer interface [polypeptide binding]; other site 288681003879 substrate-cofactor binding pocket; other site 288681003880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681003881 catalytic residue [active] 288681003882 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 288681003883 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681003884 PYR/PP interface [polypeptide binding]; other site 288681003885 dimer interface [polypeptide binding]; other site 288681003886 TPP binding site [chemical binding]; other site 288681003887 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681003888 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 288681003889 TPP-binding site [chemical binding]; other site 288681003890 dimer interface [polypeptide binding]; other site 288681003891 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 288681003892 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 288681003893 putative valine binding site [chemical binding]; other site 288681003894 dimer interface [polypeptide binding]; other site 288681003895 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 288681003896 ketol-acid reductoisomerase; Provisional; Region: PRK05479 288681003897 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 288681003898 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 288681003899 2-isopropylmalate synthase; Validated; Region: PRK00915 288681003900 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 288681003901 active site 288681003902 catalytic residues [active] 288681003903 metal binding site [ion binding]; metal-binding site 288681003904 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 288681003905 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 288681003906 tartrate dehydrogenase; Region: TTC; TIGR02089 288681003907 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 288681003908 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 288681003909 substrate binding site [chemical binding]; other site 288681003910 ligand binding site [chemical binding]; other site 288681003911 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 288681003912 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 288681003913 substrate binding site [chemical binding]; other site 288681003914 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 288681003915 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 288681003916 dimer interface [polypeptide binding]; other site 288681003917 motif 1; other site 288681003918 active site 288681003919 motif 2; other site 288681003920 motif 3; other site 288681003921 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 288681003922 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 288681003923 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 288681003924 histidinol dehydrogenase; Region: hisD; TIGR00069 288681003925 NAD binding site [chemical binding]; other site 288681003926 dimerization interface [polypeptide binding]; other site 288681003927 product binding site; other site 288681003928 substrate binding site [chemical binding]; other site 288681003929 zinc binding site [ion binding]; other site 288681003930 catalytic residues [active] 288681003931 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 288681003932 putative active site pocket [active] 288681003933 4-fold oligomerization interface [polypeptide binding]; other site 288681003934 metal binding residues [ion binding]; metal-binding site 288681003935 3-fold/trimer interface [polypeptide binding]; other site 288681003936 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 288681003937 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 288681003938 putative active site [active] 288681003939 oxyanion strand; other site 288681003940 catalytic triad [active] 288681003941 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 288681003942 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 288681003943 catalytic residues [active] 288681003944 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 288681003945 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 288681003946 substrate binding site [chemical binding]; other site 288681003947 glutamase interaction surface [polypeptide binding]; other site 288681003948 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 288681003949 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 288681003950 metal binding site [ion binding]; metal-binding site 288681003951 histidinol-phosphatase; Validated; Region: PRK06740 288681003952 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 288681003953 dimer interface [polypeptide binding]; other site 288681003954 active site 288681003955 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 288681003956 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 288681003957 putative ligand binding site [chemical binding]; other site 288681003958 putative NAD binding site [chemical binding]; other site 288681003959 catalytic site [active] 288681003960 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 288681003961 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 288681003962 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681003963 Sulfatase; Region: Sulfatase; pfam00884 288681003964 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 288681003965 diaminopimelate decarboxylase; Region: lysA; TIGR01048 288681003966 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 288681003967 active site 288681003968 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681003969 substrate binding site [chemical binding]; other site 288681003970 catalytic residues [active] 288681003971 dimer interface [polypeptide binding]; other site 288681003972 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 288681003973 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 288681003974 Active Sites [active] 288681003975 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 288681003976 ATP-sulfurylase; Region: ATPS; cd00517 288681003977 active site 288681003978 HXXH motif; other site 288681003979 flexible loop; other site 288681003980 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 288681003981 AAA domain; Region: AAA_18; pfam13238 288681003982 ligand-binding site [chemical binding]; other site 288681003983 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 288681003984 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288681003985 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288681003986 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 288681003987 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 288681003988 diphthine synthase; Region: dph5; TIGR00522 288681003989 active site 288681003990 SAM binding site [chemical binding]; other site 288681003991 homodimer interface [polypeptide binding]; other site 288681003992 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 288681003993 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 288681003994 putative active site [active] 288681003995 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 288681003996 putative active site [active] 288681003997 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 288681003998 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 288681003999 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 288681004000 Na2 binding site [ion binding]; other site 288681004001 putative substrate binding site 1 [chemical binding]; other site 288681004002 Na binding site 1 [ion binding]; other site 288681004003 putative substrate binding site 2 [chemical binding]; other site 288681004004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 288681004005 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681004006 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681004007 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681004008 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681004009 Protein of unknown function (DUF402); Region: DUF402; cl00979 288681004010 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 288681004011 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 288681004012 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 288681004013 Vpu protein; Region: Vpu; pfam00558 288681004014 PspA/IM30 family; Region: PspA_IM30; pfam04012 288681004015 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 288681004016 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681004017 Histidine kinase; Region: HisKA_3; pfam07730 288681004018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004019 ATP binding site [chemical binding]; other site 288681004020 Mg2+ binding site [ion binding]; other site 288681004021 G-X-G motif; other site 288681004022 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681004023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004024 active site 288681004025 phosphorylation site [posttranslational modification] 288681004026 intermolecular recognition site; other site 288681004027 dimerization interface [polypeptide binding]; other site 288681004028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681004029 DNA binding residues [nucleotide binding] 288681004030 dimerization interface [polypeptide binding]; other site 288681004031 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681004032 E3 interaction surface; other site 288681004033 lipoyl attachment site [posttranslational modification]; other site 288681004034 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 288681004035 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681004036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681004037 S-adenosylmethionine binding site [chemical binding]; other site 288681004038 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 288681004039 Peptidase family M50; Region: Peptidase_M50; pfam02163 288681004040 active site 288681004041 putative substrate binding region [chemical binding]; other site 288681004042 hypothetical protein; Provisional; Region: PRK06770 288681004043 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 288681004044 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 288681004045 heme-binding site [chemical binding]; other site 288681004046 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 288681004047 FAD binding pocket [chemical binding]; other site 288681004048 FAD binding motif [chemical binding]; other site 288681004049 phosphate binding motif [ion binding]; other site 288681004050 beta-alpha-beta structure motif; other site 288681004051 NAD binding pocket [chemical binding]; other site 288681004052 Heme binding pocket [chemical binding]; other site 288681004053 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 288681004054 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681004055 ligand binding site [chemical binding]; other site 288681004056 flexible hinge region; other site 288681004057 non-specific DNA interactions [nucleotide binding]; other site 288681004058 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 288681004059 DNA binding site [nucleotide binding] 288681004060 sequence specific DNA binding site [nucleotide binding]; other site 288681004061 putative cAMP binding site [chemical binding]; other site 288681004062 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681004063 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 288681004064 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 288681004065 TIGR00153 family protein; Region: TIGR00153 288681004066 Transglycosylase; Region: Transgly; pfam00912 288681004067 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681004068 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681004069 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 288681004070 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 288681004071 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681004072 putative active site [active] 288681004073 heme pocket [chemical binding]; other site 288681004074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681004075 dimer interface [polypeptide binding]; other site 288681004076 phosphorylation site [posttranslational modification] 288681004077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004078 ATP binding site [chemical binding]; other site 288681004079 Mg2+ binding site [ion binding]; other site 288681004080 G-X-G motif; other site 288681004081 Protein of unknown function DUF72; Region: DUF72; pfam01904 288681004082 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 288681004083 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681004084 active site 288681004085 DNA binding site [nucleotide binding] 288681004086 Int/Topo IB signature motif; other site 288681004087 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681004088 dimerization interface [polypeptide binding]; other site 288681004089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681004090 dimer interface [polypeptide binding]; other site 288681004091 phosphorylation site [posttranslational modification] 288681004092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004093 ATP binding site [chemical binding]; other site 288681004094 Mg2+ binding site [ion binding]; other site 288681004095 G-X-G motif; other site 288681004096 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 288681004097 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 288681004098 Probable transposase; Region: OrfB_IS605; pfam01385 288681004099 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681004100 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 288681004101 Predicted integral membrane protein [Function unknown]; Region: COG0392 288681004102 Uncharacterized conserved protein [Function unknown]; Region: COG2898 288681004103 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 288681004104 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 288681004105 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288681004106 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288681004107 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288681004108 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681004109 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681004110 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 288681004111 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 288681004112 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681004113 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681004114 RNA binding surface [nucleotide binding]; other site 288681004115 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 288681004116 active site 288681004117 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288681004118 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 288681004119 catalytic residues [active] 288681004120 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 288681004121 ResB-like family; Region: ResB; pfam05140 288681004122 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 288681004123 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 288681004124 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681004125 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004126 active site 288681004127 phosphorylation site [posttranslational modification] 288681004128 intermolecular recognition site; other site 288681004129 dimerization interface [polypeptide binding]; other site 288681004130 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681004131 DNA binding site [nucleotide binding] 288681004132 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 288681004133 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681004134 dimerization interface [polypeptide binding]; other site 288681004135 PAS domain; Region: PAS; smart00091 288681004136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681004137 dimer interface [polypeptide binding]; other site 288681004138 phosphorylation site [posttranslational modification] 288681004139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004140 ATP binding site [chemical binding]; other site 288681004141 Mg2+ binding site [ion binding]; other site 288681004142 G-X-G motif; other site 288681004143 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 288681004144 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681004145 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681004146 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681004147 Predicted membrane protein [Function unknown]; Region: COG3601 288681004148 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 288681004149 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 288681004150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 288681004151 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288681004152 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681004153 ATP binding site [chemical binding]; other site 288681004154 putative Mg++ binding site [ion binding]; other site 288681004155 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681004156 nucleotide binding region [chemical binding]; other site 288681004157 ATP-binding site [chemical binding]; other site 288681004158 CAAX protease self-immunity; Region: Abi; pfam02517 288681004159 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681004160 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681004161 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681004162 putative active site [active] 288681004163 putative metal binding site [ion binding]; other site 288681004164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681004165 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 288681004166 DNA binding residues [nucleotide binding] 288681004167 B12 binding domain; Region: B12-binding_2; pfam02607 288681004168 adaptor protein; Provisional; Region: PRK02899 288681004169 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 288681004170 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 288681004171 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 288681004172 NAD(P) binding site [chemical binding]; other site 288681004173 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 288681004174 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681004175 amidase catalytic site [active] 288681004176 Zn binding residues [ion binding]; other site 288681004177 substrate binding site [chemical binding]; other site 288681004178 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 288681004179 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 288681004180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681004181 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 288681004182 active site 288681004183 homotetramer interface [polypeptide binding]; other site 288681004184 homodimer interface [polypeptide binding]; other site 288681004185 cytidylate kinase; Provisional; Region: cmk; PRK00023 288681004186 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 288681004187 CMP-binding site; other site 288681004188 The sites determining sugar specificity; other site 288681004189 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 288681004190 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 288681004191 RNA binding site [nucleotide binding]; other site 288681004192 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 288681004193 RNA binding site [nucleotide binding]; other site 288681004194 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 288681004195 RNA binding site [nucleotide binding]; other site 288681004196 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 288681004197 RNA binding site [nucleotide binding]; other site 288681004198 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 288681004199 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 288681004200 homotetramer interface [polypeptide binding]; other site 288681004201 FMN binding site [chemical binding]; other site 288681004202 homodimer contacts [polypeptide binding]; other site 288681004203 putative active site [active] 288681004204 putative substrate binding site [chemical binding]; other site 288681004205 YpzI-like protein; Region: YpzI; pfam14140 288681004206 YIEGIA protein; Region: YIEGIA; pfam14045 288681004207 GTP-binding protein Der; Reviewed; Region: PRK00093 288681004208 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 288681004209 G1 box; other site 288681004210 GTP/Mg2+ binding site [chemical binding]; other site 288681004211 Switch I region; other site 288681004212 G2 box; other site 288681004213 Switch II region; other site 288681004214 G3 box; other site 288681004215 G4 box; other site 288681004216 G5 box; other site 288681004217 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 288681004218 G1 box; other site 288681004219 GTP/Mg2+ binding site [chemical binding]; other site 288681004220 Switch I region; other site 288681004221 G2 box; other site 288681004222 G3 box; other site 288681004223 Switch II region; other site 288681004224 G4 box; other site 288681004225 G5 box; other site 288681004226 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 288681004227 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 288681004228 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 288681004229 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 288681004230 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 288681004231 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 288681004232 histone-like DNA-binding protein HU; Region: HU; cd13831 288681004233 dimer interface [polypeptide binding]; other site 288681004234 DNA binding site [nucleotide binding] 288681004235 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 288681004236 homodecamer interface [polypeptide binding]; other site 288681004237 active site 288681004238 putative catalytic site residues [active] 288681004239 zinc binding site [ion binding]; other site 288681004240 GTP-CH-I/GFRP interaction surface; other site 288681004241 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 288681004242 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 288681004243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681004244 S-adenosylmethionine binding site [chemical binding]; other site 288681004245 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 288681004246 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 288681004247 substrate binding pocket [chemical binding]; other site 288681004248 chain length determination region; other site 288681004249 substrate-Mg2+ binding site; other site 288681004250 catalytic residues [active] 288681004251 aspartate-rich region 1; other site 288681004252 active site lid residues [active] 288681004253 aspartate-rich region 2; other site 288681004254 Nucleoside diphosphate kinase; Region: NDK; pfam00334 288681004255 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 288681004256 active site 288681004257 multimer interface [polypeptide binding]; other site 288681004258 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 288681004259 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 288681004260 Tetramer interface [polypeptide binding]; other site 288681004261 active site 288681004262 FMN-binding site [chemical binding]; other site 288681004263 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 288681004264 active site 288681004265 dimer interface [polypeptide binding]; other site 288681004266 metal binding site [ion binding]; metal-binding site 288681004267 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 288681004268 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681004269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004270 homodimer interface [polypeptide binding]; other site 288681004271 catalytic residue [active] 288681004272 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 288681004273 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681004274 binding surface 288681004275 TPR motif; other site 288681004276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681004277 binding surface 288681004278 TPR motif; other site 288681004279 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681004280 binding surface 288681004281 TPR motif; other site 288681004282 hypothetical protein; Provisional; Region: PRK03636 288681004283 UPF0302 domain; Region: UPF0302; pfam08864 288681004284 IDEAL domain; Region: IDEAL; pfam08858 288681004285 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 288681004286 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 288681004287 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 288681004288 iron-sulfur cluster [ion binding]; other site 288681004289 [2Fe-2S] cluster binding site [ion binding]; other site 288681004290 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 288681004291 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 288681004292 interchain domain interface [polypeptide binding]; other site 288681004293 intrachain domain interface; other site 288681004294 heme bH binding site [chemical binding]; other site 288681004295 Qi binding site; other site 288681004296 heme bL binding site [chemical binding]; other site 288681004297 Qo binding site; other site 288681004298 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 288681004299 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 288681004300 interchain domain interface [polypeptide binding]; other site 288681004301 intrachain domain interface; other site 288681004302 Qi binding site; other site 288681004303 Qo binding site; other site 288681004304 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 288681004305 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 288681004306 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 288681004307 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 288681004308 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 288681004309 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 288681004310 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 288681004311 active site 288681004312 Fe-S cluster binding site [ion binding]; other site 288681004313 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681004314 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681004315 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681004316 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681004317 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 288681004318 homodimer interface [polypeptide binding]; other site 288681004319 metal binding site [ion binding]; metal-binding site 288681004320 dihydrodipicolinate reductase; Provisional; Region: PRK00048 288681004321 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 288681004322 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 288681004323 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 288681004324 active site 288681004325 dimer interfaces [polypeptide binding]; other site 288681004326 catalytic residues [active] 288681004327 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 288681004328 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 288681004329 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 288681004330 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 288681004331 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 288681004332 active site 288681004333 NTP binding site [chemical binding]; other site 288681004334 metal binding triad [ion binding]; metal-binding site 288681004335 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 288681004336 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 288681004337 Biotin operon repressor [Transcription]; Region: BirA; COG1654 288681004338 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 288681004339 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 288681004340 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 288681004341 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 288681004342 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 288681004343 oligomerization interface [polypeptide binding]; other site 288681004344 active site 288681004345 metal binding site [ion binding]; metal-binding site 288681004346 pantoate--beta-alanine ligase; Region: panC; TIGR00018 288681004347 Pantoate-beta-alanine ligase; Region: PanC; cd00560 288681004348 active site 288681004349 ATP-binding site [chemical binding]; other site 288681004350 pantoate-binding site; other site 288681004351 HXXH motif; other site 288681004352 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 288681004353 tetramerization interface [polypeptide binding]; other site 288681004354 active site 288681004355 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 288681004356 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681004357 active site 288681004358 catalytic site [active] 288681004359 substrate binding site [chemical binding]; other site 288681004360 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 288681004361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681004362 nucleotide binding region [chemical binding]; other site 288681004363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 288681004364 aspartate aminotransferase; Provisional; Region: PRK05764 288681004365 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681004366 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004367 homodimer interface [polypeptide binding]; other site 288681004368 catalytic residue [active] 288681004369 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 288681004370 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 288681004371 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 288681004372 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 288681004373 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681004374 minor groove reading motif; other site 288681004375 helix-hairpin-helix signature motif; other site 288681004376 substrate binding pocket [chemical binding]; other site 288681004377 active site 288681004378 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 288681004379 Transglycosylase; Region: Transgly; pfam00912 288681004380 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681004381 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 288681004382 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681004383 Interdomain contacts; other site 288681004384 Cytokine receptor motif; other site 288681004385 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 288681004386 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 288681004387 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 288681004388 YppF-like protein; Region: YppF; pfam14178 288681004389 YppG-like protein; Region: YppG; pfam14179 288681004390 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 288681004391 hypothetical protein; Provisional; Region: PRK13660 288681004392 cell division protein GpsB; Provisional; Region: PRK14127 288681004393 DivIVA domain; Region: DivI1A_domain; TIGR03544 288681004394 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 288681004395 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 288681004396 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 288681004397 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 288681004398 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 288681004399 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 288681004400 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 288681004401 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 288681004402 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 288681004403 active site 288681004404 Zn binding site [ion binding]; other site 288681004405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681004406 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681004407 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 288681004408 Phosphotransferase enzyme family; Region: APH; pfam01636 288681004409 putative active site [active] 288681004410 putative substrate binding site [chemical binding]; other site 288681004411 ATP binding site [chemical binding]; other site 288681004412 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288681004413 active site 288681004414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681004415 active site 288681004416 Sulfate transporter family; Region: Sulfate_transp; cl19250 288681004417 xanthine permease; Region: pbuX; TIGR03173 288681004418 Predicted membrane protein [Function unknown]; Region: COG2311 288681004419 Protein of unknown function (DUF418); Region: DUF418; cl12135 288681004420 Protein of unknown function (DUF418); Region: DUF418; pfam04235 288681004421 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 288681004422 Dynamin family; Region: Dynamin_N; pfam00350 288681004423 G1 box; other site 288681004424 GTP/Mg2+ binding site [chemical binding]; other site 288681004425 G2 box; other site 288681004426 Switch I region; other site 288681004427 G3 box; other site 288681004428 Switch II region; other site 288681004429 G4 box; other site 288681004430 G5 box; other site 288681004431 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288681004432 Dynamin family; Region: Dynamin_N; pfam00350 288681004433 G1 box; other site 288681004434 GTP/Mg2+ binding site [chemical binding]; other site 288681004435 G2 box; other site 288681004436 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 288681004437 G3 box; other site 288681004438 Switch II region; other site 288681004439 GTP/Mg2+ binding site [chemical binding]; other site 288681004440 G4 box; other site 288681004441 G5 box; other site 288681004442 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 288681004443 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681004444 Coenzyme A binding pocket [chemical binding]; other site 288681004445 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 288681004446 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 288681004447 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 288681004448 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 288681004449 active site residue [active] 288681004450 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 288681004451 active site residue [active] 288681004452 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 288681004453 Predicted membrane protein [Function unknown]; Region: COG3766 288681004454 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 288681004455 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 288681004456 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 288681004457 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681004458 5'-3' exonuclease; Region: 53EXOc; smart00475 288681004459 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 288681004460 active site 288681004461 metal binding site 1 [ion binding]; metal-binding site 288681004462 putative 5' ssDNA interaction site; other site 288681004463 metal binding site 3; metal-binding site 288681004464 metal binding site 2 [ion binding]; metal-binding site 288681004465 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 288681004466 putative DNA binding site [nucleotide binding]; other site 288681004467 putative metal binding site [ion binding]; other site 288681004468 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004469 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004470 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004471 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004472 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004473 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004474 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004475 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004476 Domain of unknown function DUF11; Region: DUF11; cl17728 288681004477 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004478 Domain of unknown function DUF11; Region: DUF11; cl17728 288681004479 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004480 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004481 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004482 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004483 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004484 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004485 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004486 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004487 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004488 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004489 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004490 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004491 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004492 Domain of unknown function DUF11; Region: DUF11; cl17728 288681004493 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004494 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004495 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681004496 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 288681004497 Coenzyme A binding pocket [chemical binding]; other site 288681004498 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681004499 Isochorismatase family; Region: Isochorismatase; pfam00857 288681004500 catalytic triad [active] 288681004501 conserved cis-peptide bond; other site 288681004502 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681004503 EamA-like transporter family; Region: EamA; pfam00892 288681004504 EamA-like transporter family; Region: EamA; pfam00892 288681004505 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 288681004506 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681004507 active site 288681004508 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 288681004509 active site 288681004510 catalytic residues [active] 288681004511 QueT transporter; Region: QueT; pfam06177 288681004512 hypothetical protein; Validated; Region: PRK07708 288681004513 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 288681004514 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681004515 active site 288681004516 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 288681004517 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288681004518 DNA-binding site [nucleotide binding]; DNA binding site 288681004519 RNA-binding motif; other site 288681004520 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 288681004521 LysE type translocator; Region: LysE; pfam01810 288681004522 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 288681004523 Protein of unknown function, DUF485; Region: DUF485; pfam04341 288681004524 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681004525 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 288681004526 Na binding site [ion binding]; other site 288681004527 aminotransferase; Validated; Region: PRK07678 288681004528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681004529 inhibitor-cofactor binding pocket; inhibition site 288681004530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681004531 catalytic residue [active] 288681004532 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 288681004533 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 288681004534 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681004535 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288681004536 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681004537 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681004538 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681004539 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681004540 DNA binding residues [nucleotide binding] 288681004541 drug binding residues [chemical binding]; other site 288681004542 dimer interface [polypeptide binding]; other site 288681004543 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 288681004544 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 288681004545 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 288681004546 Predicted membrane protein [Function unknown]; Region: COG2323 288681004547 Uncharacterized conserved protein [Function unknown]; Region: COG1434 288681004548 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681004549 putative active site [active] 288681004550 Tic20-like protein; Region: Tic20; pfam09685 288681004551 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 288681004552 dimer interface [polypeptide binding]; other site 288681004553 FMN binding site [chemical binding]; other site 288681004554 NADPH bind site [chemical binding]; other site 288681004555 DJ-1 family protein; Region: not_thiJ; TIGR01383 288681004556 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 288681004557 conserved cys residue [active] 288681004558 RNA polymerase factor sigma-70; Validated; Region: PRK06811 288681004559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681004560 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681004561 DNA binding residues [nucleotide binding] 288681004562 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681004563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004564 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004565 putative substrate translocation pore; other site 288681004566 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681004567 dimerization interface [polypeptide binding]; other site 288681004568 putative DNA binding site [nucleotide binding]; other site 288681004569 putative Zn2+ binding site [ion binding]; other site 288681004570 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004572 putative substrate translocation pore; other site 288681004573 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681004574 active site 288681004575 metal binding site [ion binding]; metal-binding site 288681004576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681004577 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681004578 bacterial Hfq-like; Region: Hfq; cd01716 288681004579 hexamer interface [polypeptide binding]; other site 288681004580 Sm1 motif; other site 288681004581 RNA binding site [nucleotide binding]; other site 288681004582 Sm2 motif; other site 288681004583 HD domain; Region: HD_3; pfam13023 288681004584 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 288681004585 flagellar motor protein MotP; Reviewed; Region: PRK06743 288681004586 flagellar motor protein MotS; Reviewed; Region: PRK06742 288681004587 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 288681004588 ligand binding site [chemical binding]; other site 288681004589 Response regulator receiver domain; Region: Response_reg; pfam00072 288681004590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004591 active site 288681004592 phosphorylation site [posttranslational modification] 288681004593 intermolecular recognition site; other site 288681004594 dimerization interface [polypeptide binding]; other site 288681004595 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 288681004596 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 288681004597 putative binding surface; other site 288681004598 active site 288681004599 P2 response regulator binding domain; Region: P2; pfam07194 288681004600 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 288681004601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004602 ATP binding site [chemical binding]; other site 288681004603 Mg2+ binding site [ion binding]; other site 288681004604 G-X-G motif; other site 288681004605 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 288681004606 flagellar motor switch protein; Reviewed; Region: PRK06782 288681004607 CheC-like family; Region: CheC; pfam04509 288681004608 CheC-like family; Region: CheC; pfam04509 288681004609 CheC-like family; Region: CheC; pfam04509 288681004610 CheC-like family; Region: CheC; pfam04509 288681004611 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 288681004612 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 288681004613 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 288681004614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681004615 Protein of unknown function (DUF327); Region: DUF327; pfam03885 288681004616 Glutamate-cysteine ligase; Region: GshA; pfam08886 288681004617 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 288681004618 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 288681004619 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 288681004620 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 288681004621 flagellar capping protein; Validated; Region: fliD; PRK06798 288681004622 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 288681004623 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 288681004624 Flagellar protein FliS; Region: FliS; cl00654 288681004625 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 288681004626 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 288681004627 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 288681004628 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 288681004629 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 288681004630 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 288681004631 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 288681004632 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 288681004633 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 288681004634 FliG C-terminal domain; Region: FliG_C; pfam01706 288681004635 flagellar assembly protein H; Validated; Region: fliH; PRK06800 288681004636 Flagellar assembly protein FliH; Region: FliH; pfam02108 288681004637 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 288681004638 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288681004639 Walker A motif; other site 288681004640 ATP binding site [chemical binding]; other site 288681004641 Walker B motif; other site 288681004642 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 288681004643 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 288681004644 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 288681004645 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 288681004646 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 288681004647 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 288681004648 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 288681004649 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 288681004650 Response regulator receiver domain; Region: Response_reg; pfam00072 288681004651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004652 active site 288681004653 phosphorylation site [posttranslational modification] 288681004654 intermolecular recognition site; other site 288681004655 dimerization interface [polypeptide binding]; other site 288681004656 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 288681004657 flagellin; Provisional; Region: PRK12807 288681004658 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 288681004659 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 288681004660 flagellin; Provisional; Region: PRK12808 288681004661 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 288681004662 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 288681004663 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 288681004664 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 288681004665 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288681004666 catalytic residue [active] 288681004667 flagellar motor switch protein; Validated; Region: PRK06789 288681004668 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 288681004669 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 288681004670 flagellar motor switch protein; Validated; Region: PRK06788 288681004671 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 288681004672 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 288681004673 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 288681004674 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 288681004675 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 288681004676 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 288681004677 FHIPEP family; Region: FHIPEP; pfam00771 288681004678 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 288681004679 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 288681004680 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 288681004681 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 288681004682 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 288681004683 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 288681004684 Predicted transcriptional regulators [Transcription]; Region: COG1378 288681004685 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 288681004686 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 288681004687 C-terminal domain interface [polypeptide binding]; other site 288681004688 sugar binding site [chemical binding]; other site 288681004689 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 288681004690 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 288681004691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681004692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681004693 Dienelactone hydrolase family; Region: DLH; pfam01738 288681004694 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 288681004695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681004696 non-specific DNA binding site [nucleotide binding]; other site 288681004697 salt bridge; other site 288681004698 sequence-specific DNA binding site [nucleotide binding]; other site 288681004699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004700 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004701 putative substrate translocation pore; other site 288681004702 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 288681004703 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681004704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681004705 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681004706 dimerization interface [polypeptide binding]; other site 288681004707 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 288681004708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681004709 Walker A/P-loop; other site 288681004710 ATP binding site [chemical binding]; other site 288681004711 Q-loop/lid; other site 288681004712 ABC transporter signature motif; other site 288681004713 Walker B; other site 288681004714 D-loop; other site 288681004715 H-loop/switch region; other site 288681004716 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 288681004717 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 288681004718 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 288681004719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004720 dimer interface [polypeptide binding]; other site 288681004721 conserved gate region; other site 288681004722 putative PBP binding loops; other site 288681004723 ABC-ATPase subunit interface; other site 288681004724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004725 dimer interface [polypeptide binding]; other site 288681004726 conserved gate region; other site 288681004727 putative PBP binding loops; other site 288681004728 ABC-ATPase subunit interface; other site 288681004729 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 288681004730 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 288681004731 Beta-Casp domain; Region: Beta-Casp; pfam10996 288681004732 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681004733 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 288681004734 Cupin; Region: Cupin_1; smart00835 288681004735 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 288681004736 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 288681004737 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681004738 catalytic core [active] 288681004739 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681004740 hypothetical protein; Provisional; Region: PRK09272 288681004741 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681004742 MarR family; Region: MarR_2; pfam12802 288681004743 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681004744 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288681004745 active site 288681004746 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 288681004747 dimer interface [polypeptide binding]; other site 288681004748 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288681004749 Ligand Binding Site [chemical binding]; other site 288681004750 Molecular Tunnel; other site 288681004751 RNA polymerase factor sigma-70; Validated; Region: PRK06811 288681004752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681004753 DNA binding residues [nucleotide binding] 288681004754 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 288681004755 VPS10 domain; Region: VPS10; smart00602 288681004756 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 288681004757 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681004758 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 288681004759 DNA-binding site [nucleotide binding]; DNA binding site 288681004760 FCD domain; Region: FCD; pfam07729 288681004761 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681004762 EamA-like transporter family; Region: EamA; pfam00892 288681004763 EamA-like transporter family; Region: EamA; pfam00892 288681004764 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288681004765 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 288681004766 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 288681004767 Methyltransferase domain; Region: Methyltransf_24; pfam13578 288681004768 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 288681004769 fumarate hydratase; Reviewed; Region: fumC; PRK00485 288681004770 Class II fumarases; Region: Fumarase_classII; cd01362 288681004771 active site 288681004772 tetramer interface [polypeptide binding]; other site 288681004773 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681004774 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 288681004775 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288681004776 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 288681004777 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 288681004778 active site pocket [active] 288681004779 oxyanion hole [active] 288681004780 catalytic triad [active] 288681004781 active site nucleophile [active] 288681004782 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 288681004783 Penicillinase repressor; Region: Penicillinase_R; pfam03965 288681004784 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 288681004785 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 288681004786 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 288681004787 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288681004788 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 288681004789 catalytic residues [active] 288681004790 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 288681004791 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681004792 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681004793 non-specific DNA binding site [nucleotide binding]; other site 288681004794 salt bridge; other site 288681004795 sequence-specific DNA binding site [nucleotide binding]; other site 288681004796 Cupin domain; Region: Cupin_2; pfam07883 288681004797 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 288681004798 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 288681004799 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681004800 catalytic residue [active] 288681004801 Protein of unknown function (DUF445); Region: DUF445; pfam04286 288681004802 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 288681004803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681004804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681004805 DNA binding residues [nucleotide binding] 288681004806 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681004807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004808 active site 288681004809 phosphorylation site [posttranslational modification] 288681004810 intermolecular recognition site; other site 288681004811 dimerization interface [polypeptide binding]; other site 288681004812 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681004813 DNA binding residues [nucleotide binding] 288681004814 dimerization interface [polypeptide binding]; other site 288681004815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681004816 Histidine kinase; Region: HisKA_3; pfam07730 288681004817 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681004818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681004819 Walker A/P-loop; other site 288681004820 ATP binding site [chemical binding]; other site 288681004821 Q-loop/lid; other site 288681004822 ABC transporter signature motif; other site 288681004823 Walker B; other site 288681004824 D-loop; other site 288681004825 H-loop/switch region; other site 288681004826 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 288681004827 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 288681004828 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 288681004829 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 288681004830 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681004831 PLD-like domain; Region: PLDc_2; pfam13091 288681004832 putative active site [active] 288681004833 catalytic site [active] 288681004834 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681004835 PLD-like domain; Region: PLDc_2; pfam13091 288681004836 putative active site [active] 288681004837 catalytic site [active] 288681004838 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 288681004839 putative nucleotide binding site [chemical binding]; other site 288681004840 uridine monophosphate binding site [chemical binding]; other site 288681004841 homohexameric interface [polypeptide binding]; other site 288681004842 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681004843 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 288681004844 aspartate ammonia-lyase; Provisional; Region: PRK14515 288681004845 Aspartase; Region: Aspartase; cd01357 288681004846 active sites [active] 288681004847 tetramer interface [polypeptide binding]; other site 288681004848 malate dehydrogenase; Provisional; Region: PRK13529 288681004849 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288681004850 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 288681004851 NAD(P) binding site [chemical binding]; other site 288681004852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681004853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681004854 ATP binding site [chemical binding]; other site 288681004855 Mg2+ binding site [ion binding]; other site 288681004856 G-X-G motif; other site 288681004857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681004858 Response regulator receiver domain; Region: Response_reg; pfam00072 288681004859 active site 288681004860 phosphorylation site [posttranslational modification] 288681004861 intermolecular recognition site; other site 288681004862 dimerization interface [polypeptide binding]; other site 288681004863 YcbB domain; Region: YcbB; pfam08664 288681004864 SWIM zinc finger; Region: SWIM; pfam04434 288681004865 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 288681004866 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 288681004867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681004868 ATP binding site [chemical binding]; other site 288681004869 putative Mg++ binding site [ion binding]; other site 288681004870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681004871 nucleotide binding region [chemical binding]; other site 288681004872 ATP-binding site [chemical binding]; other site 288681004873 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 288681004874 dimer interface [polypeptide binding]; other site 288681004875 active site 288681004876 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681004877 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681004878 non-specific DNA binding site [nucleotide binding]; other site 288681004879 salt bridge; other site 288681004880 sequence-specific DNA binding site [nucleotide binding]; other site 288681004881 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 288681004882 putative dimer interface [polypeptide binding]; other site 288681004883 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681004884 aspartate kinase; Reviewed; Region: PRK06635 288681004885 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 288681004886 putative nucleotide binding site [chemical binding]; other site 288681004887 putative catalytic residues [active] 288681004888 putative Mg ion binding site [ion binding]; other site 288681004889 putative aspartate binding site [chemical binding]; other site 288681004890 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 288681004891 putative allosteric regulatory site; other site 288681004892 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 288681004893 putative allosteric regulatory residue; other site 288681004894 DoxX-like family; Region: DoxX_3; pfam13781 288681004895 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 288681004896 YndJ-like protein; Region: YndJ; pfam14158 288681004897 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681004898 putative active site [active] 288681004899 nucleotide binding site [chemical binding]; other site 288681004900 nudix motif; other site 288681004901 putative metal binding site [ion binding]; other site 288681004902 S-layer homology domain; Region: SLH; pfam00395 288681004903 S-layer homology domain; Region: SLH; pfam00395 288681004904 S-layer homology domain; Region: SLH; pfam00395 288681004905 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 288681004906 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681004907 active site 288681004908 metal binding site [ion binding]; metal-binding site 288681004909 S-layer homology domain; Region: SLH; pfam00395 288681004910 S-layer homology domain; Region: SLH; pfam00395 288681004911 S-layer homology domain; Region: SLH; pfam00395 288681004912 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 288681004913 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681004914 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004915 putative substrate translocation pore; other site 288681004916 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288681004917 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 288681004918 Walker A/P-loop; other site 288681004919 ATP binding site [chemical binding]; other site 288681004920 Q-loop/lid; other site 288681004921 ABC transporter signature motif; other site 288681004922 Walker B; other site 288681004923 D-loop; other site 288681004924 H-loop/switch region; other site 288681004925 TOBE domain; Region: TOBE; pfam03459 288681004926 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 288681004927 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 288681004928 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288681004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004930 dimer interface [polypeptide binding]; other site 288681004931 conserved gate region; other site 288681004932 putative PBP binding loops; other site 288681004933 ABC-ATPase subunit interface; other site 288681004934 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288681004935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681004936 dimer interface [polypeptide binding]; other site 288681004937 conserved gate region; other site 288681004938 putative PBP binding loops; other site 288681004939 ABC-ATPase subunit interface; other site 288681004940 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681004941 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681004942 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288681004943 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681004944 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681004945 DNA-binding site [nucleotide binding]; DNA binding site 288681004946 UTRA domain; Region: UTRA; pfam07702 288681004947 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 288681004948 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 288681004949 dimer interface [polypeptide binding]; other site 288681004950 active site 288681004951 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 288681004952 putative active site [active] 288681004953 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 288681004954 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 288681004955 active site 288681004956 dimer interface [polypeptide binding]; other site 288681004957 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 288681004958 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681004959 intersubunit interface [polypeptide binding]; other site 288681004960 active site 288681004961 zinc binding site [ion binding]; other site 288681004962 Na+ binding site [ion binding]; other site 288681004963 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 288681004964 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 288681004965 putative substrate binding site [chemical binding]; other site 288681004966 putative ATP binding site [chemical binding]; other site 288681004967 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681004968 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681004969 nucleotide binding site [chemical binding]; other site 288681004970 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 288681004971 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681004972 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681004973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681004975 putative substrate translocation pore; other site 288681004976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681004977 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681004978 putative substrate translocation pore; other site 288681004979 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 288681004980 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681004981 dimer interface [polypeptide binding]; other site 288681004982 active site 288681004983 CoA binding pocket [chemical binding]; other site 288681004984 NTR domain, TIMP-like subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by...; Region: NTR_TIMP_like; cd03577 288681004985 Metzincin-binding interface; other site 288681004986 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 288681004987 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 288681004988 HflX GTPase family; Region: HflX; cd01878 288681004989 G1 box; other site 288681004990 GTP/Mg2+ binding site [chemical binding]; other site 288681004991 Switch I region; other site 288681004992 G2 box; other site 288681004993 G3 box; other site 288681004994 Switch II region; other site 288681004995 G4 box; other site 288681004996 G5 box; other site 288681004997 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681004998 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681004999 peptide binding site [polypeptide binding]; other site 288681005000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681005002 putative substrate translocation pore; other site 288681005003 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288681005004 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288681005005 dimer interface [polypeptide binding]; other site 288681005006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005007 catalytic residue [active] 288681005008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005009 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681005010 Coenzyme A binding pocket [chemical binding]; other site 288681005011 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 288681005012 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 288681005013 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 288681005014 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 288681005015 Na2 binding site [ion binding]; other site 288681005016 putative substrate binding site 1 [chemical binding]; other site 288681005017 Na binding site 1 [ion binding]; other site 288681005018 putative substrate binding site 2 [chemical binding]; other site 288681005019 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681005020 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 288681005021 NodB motif; other site 288681005022 putative active site [active] 288681005023 putative catalytic site [active] 288681005024 putative Zn binding site [ion binding]; other site 288681005025 Mor transcription activator family; Region: Mor; cl02360 288681005026 Predicted membrane protein [Function unknown]; Region: COG2323 288681005027 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 288681005028 methionine sulfoxide reductase A; Provisional; Region: PRK14054 288681005029 short chain dehydrogenase; Provisional; Region: PRK12747 288681005030 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 288681005031 NADP binding site [chemical binding]; other site 288681005032 homodimer interface [polypeptide binding]; other site 288681005033 active site 288681005034 substrate binding site [chemical binding]; other site 288681005035 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 288681005036 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681005037 homodimer interface [polypeptide binding]; other site 288681005038 substrate-cofactor binding pocket; other site 288681005039 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005040 catalytic residue [active] 288681005041 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 288681005042 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681005043 PYR/PP interface [polypeptide binding]; other site 288681005044 dimer interface [polypeptide binding]; other site 288681005045 TPP binding site [chemical binding]; other site 288681005046 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681005047 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 288681005048 TPP-binding site [chemical binding]; other site 288681005049 dimer interface [polypeptide binding]; other site 288681005050 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 288681005051 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 288681005052 putative valine binding site [chemical binding]; other site 288681005053 dimer interface [polypeptide binding]; other site 288681005054 ketol-acid reductoisomerase; Provisional; Region: PRK05479 288681005055 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 288681005056 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 288681005057 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 288681005058 threonine dehydratase; Validated; Region: PRK08639 288681005059 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 288681005060 tetramer interface [polypeptide binding]; other site 288681005061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005062 catalytic residue [active] 288681005063 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 288681005064 putative Ile/Val binding site [chemical binding]; other site 288681005065 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 288681005066 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 288681005067 putative active site [active] 288681005068 putative metal binding site [ion binding]; other site 288681005069 Protein of unknown function (DUF554); Region: DUF554; pfam04474 288681005070 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005071 Coenzyme A binding pocket [chemical binding]; other site 288681005072 drug efflux system protein MdtG; Provisional; Region: PRK09874 288681005073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005074 putative substrate translocation pore; other site 288681005075 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 288681005076 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 288681005077 putative active site [active] 288681005078 metal binding site [ion binding]; metal-binding site 288681005079 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 288681005080 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681005081 LytTr DNA-binding domain; Region: LytTR; pfam04397 288681005082 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681005083 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 288681005084 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 288681005085 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 288681005086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005088 Coenzyme A binding pocket [chemical binding]; other site 288681005089 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 288681005090 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 288681005091 active site 288681005092 putative substrate binding pocket [chemical binding]; other site 288681005093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681005094 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681005095 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681005096 peptide binding site [polypeptide binding]; other site 288681005097 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 288681005098 hypothetical protein; Provisional; Region: PRK06922 288681005099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005100 S-adenosylmethionine binding site [chemical binding]; other site 288681005101 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 288681005102 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681005103 FeS/SAM binding site; other site 288681005104 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 288681005105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681005106 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681005107 Coenzyme A binding pocket [chemical binding]; other site 288681005108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681005109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681005110 active site 288681005111 phosphorylation site [posttranslational modification] 288681005112 intermolecular recognition site; other site 288681005113 dimerization interface [polypeptide binding]; other site 288681005114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681005115 DNA binding site [nucleotide binding] 288681005116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681005117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681005118 dimerization interface [polypeptide binding]; other site 288681005119 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681005120 dimer interface [polypeptide binding]; other site 288681005121 phosphorylation site [posttranslational modification] 288681005122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005123 ATP binding site [chemical binding]; other site 288681005124 Mg2+ binding site [ion binding]; other site 288681005125 G-X-G motif; other site 288681005126 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681005127 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681005128 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681005129 manganese transport protein MntH; Reviewed; Region: PRK00701 288681005130 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 288681005131 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 288681005132 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 288681005133 active site residue [active] 288681005134 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 288681005135 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 288681005136 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 288681005137 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 288681005138 Amino acid permease; Region: AA_permease_2; pfam13520 288681005139 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 288681005140 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 288681005141 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 288681005142 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 288681005143 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288681005144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681005145 DNA binding residues [nucleotide binding] 288681005146 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288681005147 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 288681005148 intersubunit interface [polypeptide binding]; other site 288681005149 active site 288681005150 catalytic residue [active] 288681005151 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681005152 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681005153 Nucleoside recognition; Region: Gate; pfam07670 288681005154 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681005155 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 288681005156 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288681005157 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288681005158 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 288681005159 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 288681005160 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681005161 active site 288681005162 catalytic motif [active] 288681005163 Zn binding site [ion binding]; other site 288681005164 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 288681005165 hypothetical protein; Provisional; Region: PRK01631 288681005166 Family description; Region: DsbD_2; pfam13386 288681005167 VPS10 domain; Region: VPS10; smart00602 288681005168 proline aminopeptidase P II; Provisional; Region: PRK10879 288681005169 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 288681005170 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 288681005171 active site 288681005172 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 288681005173 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 288681005174 Condensation domain; Region: Condensation; pfam00668 288681005175 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288681005176 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288681005177 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681005178 acyl-activating enzyme (AAE) consensus motif; other site 288681005179 AMP binding site [chemical binding]; other site 288681005180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681005181 Condensation domain; Region: Condensation; pfam00668 288681005182 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 288681005183 Condensation domain; Region: Condensation; pfam00668 288681005184 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288681005185 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681005186 acyl-activating enzyme (AAE) consensus motif; other site 288681005187 AMP binding site [chemical binding]; other site 288681005188 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681005189 Condensation domain; Region: Condensation; pfam00668 288681005190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288681005191 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288681005192 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681005193 acyl-activating enzyme (AAE) consensus motif; other site 288681005194 AMP binding site [chemical binding]; other site 288681005195 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681005196 Condensation domain; Region: Condensation; pfam00668 288681005197 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 288681005198 Condensation domain; Region: Condensation; pfam00668 288681005199 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288681005200 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681005201 acyl-activating enzyme (AAE) consensus motif; other site 288681005202 AMP binding site [chemical binding]; other site 288681005203 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681005204 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681005205 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 288681005206 acyl-activating enzyme (AAE) consensus motif; other site 288681005207 AMP binding site [chemical binding]; other site 288681005208 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681005209 Condensation domain; Region: Condensation; pfam00668 288681005210 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 288681005211 Condensation domain; Region: Condensation; pfam00668 288681005212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 288681005213 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681005214 acyl-activating enzyme (AAE) consensus motif; other site 288681005215 AMP binding site [chemical binding]; other site 288681005216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681005217 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681005218 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681005219 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 288681005220 Walker A/P-loop; other site 288681005221 ATP binding site [chemical binding]; other site 288681005222 Q-loop/lid; other site 288681005223 ABC transporter signature motif; other site 288681005224 Walker B; other site 288681005225 D-loop; other site 288681005226 H-loop/switch region; other site 288681005227 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 288681005228 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 288681005229 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681005230 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681005231 Walker A/P-loop; other site 288681005232 ATP binding site [chemical binding]; other site 288681005233 Q-loop/lid; other site 288681005234 ABC transporter signature motif; other site 288681005235 Walker B; other site 288681005236 D-loop; other site 288681005237 H-loop/switch region; other site 288681005238 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681005239 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 288681005240 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681005241 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681005242 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681005243 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 288681005244 DNA topoisomerase III; Provisional; Region: PRK07726 288681005245 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 288681005246 active site 288681005247 putative interdomain interaction site [polypeptide binding]; other site 288681005248 putative metal-binding site [ion binding]; other site 288681005249 putative nucleotide binding site [chemical binding]; other site 288681005250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288681005251 domain I; other site 288681005252 DNA binding groove [nucleotide binding] 288681005253 phosphate binding site [ion binding]; other site 288681005254 domain II; other site 288681005255 domain III; other site 288681005256 nucleotide binding site [chemical binding]; other site 288681005257 catalytic site [active] 288681005258 domain IV; other site 288681005259 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 288681005260 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 288681005261 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 288681005262 Sodium Bile acid symporter family; Region: SBF; cl17470 288681005263 azoreductase; Provisional; Region: PRK13555 288681005264 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 288681005265 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681005266 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 288681005267 dimer interface [polypeptide binding]; other site 288681005268 substrate binding site [chemical binding]; other site 288681005269 metal binding site [ion binding]; metal-binding site 288681005270 CopC domain; Region: CopC; pfam04234 288681005271 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 288681005272 YtkA-like; Region: YtkA; pfam13115 288681005273 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 288681005274 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681005275 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 288681005276 EamA-like transporter family; Region: EamA; pfam00892 288681005277 EamA-like transporter family; Region: EamA; pfam00892 288681005278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681005279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681005280 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681005281 dimerization interface [polypeptide binding]; other site 288681005282 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681005283 Transcriptional regulator; Region: Rrf2; pfam02082 288681005284 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 288681005285 catalytic residues [active] 288681005286 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681005287 dimer interface [polypeptide binding]; other site 288681005288 FMN binding site [chemical binding]; other site 288681005289 amidase; Provisional; Region: PRK06707 288681005290 Amidase; Region: Amidase; cl11426 288681005291 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681005292 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 288681005293 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 288681005294 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681005295 NAD binding site [chemical binding]; other site 288681005296 dimer interface [polypeptide binding]; other site 288681005297 substrate binding site [chemical binding]; other site 288681005298 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 288681005299 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681005300 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288681005301 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 288681005302 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 288681005303 S-layer homology domain; Region: SLH; pfam00395 288681005304 S-layer homology domain; Region: SLH; pfam00395 288681005305 S-layer homology domain; Region: SLH; pfam00395 288681005306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681005307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681005308 acyl-CoA synthetase; Validated; Region: PRK06839 288681005309 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681005310 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 288681005311 acyl-activating enzyme (AAE) consensus motif; other site 288681005312 putative AMP binding site [chemical binding]; other site 288681005313 putative active site [active] 288681005314 putative CoA binding site [chemical binding]; other site 288681005315 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 288681005316 dimer interaction site [polypeptide binding]; other site 288681005317 substrate-binding tunnel; other site 288681005318 active site 288681005319 catalytic site [active] 288681005320 substrate binding site [chemical binding]; other site 288681005321 hypothetical protein; Validated; Region: PRK06840 288681005322 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 288681005323 active site 288681005324 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 288681005325 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 288681005326 putative ligand binding site [chemical binding]; other site 288681005327 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 288681005328 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 288681005329 Walker A/P-loop; other site 288681005330 ATP binding site [chemical binding]; other site 288681005331 Q-loop/lid; other site 288681005332 ABC transporter signature motif; other site 288681005333 Walker B; other site 288681005334 D-loop; other site 288681005335 H-loop/switch region; other site 288681005336 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 288681005337 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 288681005338 Walker A/P-loop; other site 288681005339 ATP binding site [chemical binding]; other site 288681005340 Q-loop/lid; other site 288681005341 ABC transporter signature motif; other site 288681005342 Walker B; other site 288681005343 D-loop; other site 288681005344 H-loop/switch region; other site 288681005345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288681005346 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 288681005347 TM-ABC transporter signature motif; other site 288681005348 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 288681005349 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 288681005350 TM-ABC transporter signature motif; other site 288681005351 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681005352 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 288681005353 LysR substrate binding domain; Region: LysR_substrate; pfam03466 288681005354 dimerization interface [polypeptide binding]; other site 288681005355 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 288681005356 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681005357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681005358 putative Zn2+ binding site [ion binding]; other site 288681005359 putative DNA binding site [nucleotide binding]; other site 288681005360 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 288681005361 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288681005362 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 288681005363 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 288681005364 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 288681005365 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 288681005366 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 288681005367 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 288681005368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681005369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681005370 Walker A/P-loop; other site 288681005371 ATP binding site [chemical binding]; other site 288681005372 Q-loop/lid; other site 288681005373 ABC transporter signature motif; other site 288681005374 Walker B; other site 288681005375 D-loop; other site 288681005376 H-loop/switch region; other site 288681005377 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 288681005378 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681005379 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 288681005380 Walker A/P-loop; other site 288681005381 ATP binding site [chemical binding]; other site 288681005382 Q-loop/lid; other site 288681005383 ABC transporter signature motif; other site 288681005384 Walker B; other site 288681005385 D-loop; other site 288681005386 H-loop/switch region; other site 288681005387 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3972 288681005388 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681005389 putative dimer interface [polypeptide binding]; other site 288681005390 catalytic triad [active] 288681005391 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681005392 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681005393 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681005394 dimer interface [polypeptide binding]; other site 288681005395 FMN binding site [chemical binding]; other site 288681005396 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681005397 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681005398 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681005399 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288681005400 NlpC/P60 family; Region: NLPC_P60; pfam00877 288681005401 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681005402 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681005403 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681005404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681005405 Walker A/P-loop; other site 288681005406 ATP binding site [chemical binding]; other site 288681005407 Q-loop/lid; other site 288681005408 ABC transporter signature motif; other site 288681005409 Walker B; other site 288681005410 D-loop; other site 288681005411 H-loop/switch region; other site 288681005412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681005413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681005414 active site 288681005415 phosphorylation site [posttranslational modification] 288681005416 intermolecular recognition site; other site 288681005417 dimerization interface [polypeptide binding]; other site 288681005418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681005419 DNA binding site [nucleotide binding] 288681005420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681005421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681005422 dimerization interface [polypeptide binding]; other site 288681005423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681005424 dimer interface [polypeptide binding]; other site 288681005425 phosphorylation site [posttranslational modification] 288681005426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005427 ATP binding site [chemical binding]; other site 288681005428 Mg2+ binding site [ion binding]; other site 288681005429 G-X-G motif; other site 288681005430 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 288681005431 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 288681005432 classical (c) SDRs; Region: SDR_c; cd05233 288681005433 NAD(P) binding site [chemical binding]; other site 288681005434 active site 288681005435 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288681005436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005437 S-adenosylmethionine binding site [chemical binding]; other site 288681005438 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 288681005439 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681005440 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 288681005441 NodB motif; other site 288681005442 active site 288681005443 catalytic site [active] 288681005444 metal binding site [ion binding]; metal-binding site 288681005445 SdpI/YhfL protein family; Region: SdpI; pfam13630 288681005446 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681005447 nudix motif; other site 288681005448 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 288681005449 homoserine dehydrogenase; Provisional; Region: PRK06349 288681005450 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 288681005451 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288681005452 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 288681005453 threonine synthase; Reviewed; Region: PRK06721 288681005454 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 288681005455 homodimer interface [polypeptide binding]; other site 288681005456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005457 catalytic residue [active] 288681005458 homoserine kinase; Provisional; Region: PRK01212 288681005459 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 288681005460 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288681005461 Protein of unknown function (DUF1183); Region: DUF1183; pfam06682 288681005462 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 288681005463 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 288681005464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681005465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681005466 active site 288681005467 phosphorylation site [posttranslational modification] 288681005468 intermolecular recognition site; other site 288681005469 dimerization interface [polypeptide binding]; other site 288681005470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681005471 DNA binding site [nucleotide binding] 288681005472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681005473 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681005474 dimerization interface [polypeptide binding]; other site 288681005475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681005476 dimer interface [polypeptide binding]; other site 288681005477 phosphorylation site [posttranslational modification] 288681005478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681005479 ATP binding site [chemical binding]; other site 288681005480 Mg2+ binding site [ion binding]; other site 288681005481 G-X-G motif; other site 288681005482 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681005483 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681005484 NodB motif; other site 288681005485 active site 288681005486 catalytic site [active] 288681005487 Zn binding site [ion binding]; other site 288681005488 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 288681005489 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 288681005490 MgtC family; Region: MgtC; pfam02308 288681005491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005493 Coenzyme A binding pocket [chemical binding]; other site 288681005494 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 288681005495 IucA / IucC family; Region: IucA_IucC; pfam04183 288681005496 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 288681005497 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 288681005498 IucA / IucC family; Region: IucA_IucC; pfam04183 288681005499 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 288681005500 acyl-CoA synthetase; Validated; Region: PRK08308 288681005501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681005502 acyl-activating enzyme (AAE) consensus motif; other site 288681005503 AMP binding site [chemical binding]; other site 288681005504 active site 288681005505 CoA binding site [chemical binding]; other site 288681005506 acyl carrier protein; Provisional; Region: PRK07639 288681005507 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681005508 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681005509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005510 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681005511 putative substrate translocation pore; other site 288681005512 Lysine efflux permease [General function prediction only]; Region: COG1279 288681005513 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681005514 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681005515 DNA-binding site [nucleotide binding]; DNA binding site 288681005516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681005517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005518 homodimer interface [polypeptide binding]; other site 288681005519 catalytic residue [active] 288681005520 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 288681005521 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 288681005522 active site 288681005523 nucleophile elbow; other site 288681005524 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 288681005525 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 288681005526 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 288681005527 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681005528 nudix motif; other site 288681005529 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 288681005530 homodimer interface [polypeptide binding]; other site 288681005531 NAD binding pocket [chemical binding]; other site 288681005532 ATP binding pocket [chemical binding]; other site 288681005533 Mg binding site [ion binding]; other site 288681005534 active-site loop [active] 288681005535 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681005536 FtsX-like permease family; Region: FtsX; pfam02687 288681005537 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005538 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681005539 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 288681005540 Subtilase family; Region: Peptidase_S8; pfam00082 288681005541 active site 288681005542 catalytic residues [active] 288681005543 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681005544 dimerization interface [polypeptide binding]; other site 288681005545 putative DNA binding site [nucleotide binding]; other site 288681005546 putative Zn2+ binding site [ion binding]; other site 288681005547 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681005548 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681005549 active site 288681005550 catalytic tetrad [active] 288681005551 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681005552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005553 putative substrate translocation pore; other site 288681005554 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 288681005555 Protein of unknown function (DUF664); Region: DUF664; pfam04978 288681005556 DinB superfamily; Region: DinB_2; pfam12867 288681005557 GTPase RsgA; Reviewed; Region: PRK01889 288681005558 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681005559 RNA binding site [nucleotide binding]; other site 288681005560 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 288681005561 GTPase/Zn-binding domain interface [polypeptide binding]; other site 288681005562 GTP/Mg2+ binding site [chemical binding]; other site 288681005563 G4 box; other site 288681005564 G5 box; other site 288681005565 G1 box; other site 288681005566 Switch I region; other site 288681005567 G2 box; other site 288681005568 G3 box; other site 288681005569 Switch II region; other site 288681005570 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 288681005571 Cache domain; Region: Cache_1; pfam02743 288681005572 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681005573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681005574 dimerization interface [polypeptide binding]; other site 288681005575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681005576 dimer interface [polypeptide binding]; other site 288681005577 putative CheW interface [polypeptide binding]; other site 288681005578 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 288681005579 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288681005580 Ferritin-like domain; Region: Ferritin; pfam00210 288681005581 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 288681005582 dimerization interface [polypeptide binding]; other site 288681005583 DPS ferroxidase diiron center [ion binding]; other site 288681005584 ion pore; other site 288681005585 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 288681005586 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681005587 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 288681005588 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 288681005589 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 288681005590 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 288681005591 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681005592 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681005593 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681005594 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681005595 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681005596 active site 288681005597 catalytic tetrad [active] 288681005598 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 288681005599 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 288681005600 P-loop, Walker A motif; other site 288681005601 Base recognition motif; other site 288681005602 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 288681005603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005605 Coenzyme A binding pocket [chemical binding]; other site 288681005606 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959 288681005607 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681005608 transposase (08) fragment; frameshift mutation 288681005609 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 288681005610 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 288681005611 metal binding site [ion binding]; metal-binding site 288681005612 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 288681005613 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681005614 NAD binding site [chemical binding]; other site 288681005615 active site 288681005616 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 288681005617 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 288681005618 active site 288681005619 FMN binding site [chemical binding]; other site 288681005620 substrate binding site [chemical binding]; other site 288681005621 homotetramer interface [polypeptide binding]; other site 288681005622 catalytic residue [active] 288681005623 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 288681005624 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 288681005625 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288681005626 DNA binding site [nucleotide binding] 288681005627 active site 288681005628 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 288681005629 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681005630 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681005631 peptide binding site [polypeptide binding]; other site 288681005632 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 288681005633 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681005634 active site 288681005635 metal binding site [ion binding]; metal-binding site 288681005636 short chain dehydrogenase; Provisional; Region: PRK08309 288681005637 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681005638 catalytic core [active] 288681005639 CotH protein; Region: CotH; pfam08757 288681005640 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 288681005641 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 288681005642 nudix motif; other site 288681005643 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681005644 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288681005645 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 288681005646 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 288681005647 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 288681005648 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 288681005649 Cl binding site [ion binding]; other site 288681005650 oligomer interface [polypeptide binding]; other site 288681005651 Predicted permeases [General function prediction only]; Region: COG0701 288681005652 Predicted membrane protein [Function unknown]; Region: COG3689 288681005653 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 288681005654 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681005655 PLD-like domain; Region: PLDc_2; pfam13091 288681005656 putative active site [active] 288681005657 catalytic site [active] 288681005658 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681005659 PLD-like domain; Region: PLDc_2; pfam13091 288681005660 putative active site [active] 288681005661 catalytic site [active] 288681005662 Coat F domain; Region: Coat_F; pfam07875 288681005663 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 288681005664 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681005665 NAD binding site [chemical binding]; other site 288681005666 substrate binding site [chemical binding]; other site 288681005667 putative active site [active] 288681005668 Protein of unknown function (DUF456); Region: DUF456; pfam04306 288681005669 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681005670 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681005671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681005672 Transporter associated domain; Region: CorC_HlyC; smart01091 288681005673 FOG: CBS domain [General function prediction only]; Region: COG0517 288681005674 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 288681005675 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 288681005676 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 288681005677 dimer interface [polypeptide binding]; other site 288681005678 putative tRNA-binding site [nucleotide binding]; other site 288681005679 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 288681005680 DinB superfamily; Region: DinB_2; pfam12867 288681005681 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 288681005682 stage II sporulation protein P; Region: spore_II_P; TIGR02867 288681005683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681005684 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005685 Coenzyme A binding pocket [chemical binding]; other site 288681005686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681005687 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 288681005688 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288681005689 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 288681005690 nudix motif; other site 288681005691 amidase; Provisional; Region: PRK06828 288681005692 Amidase; Region: Amidase; pfam01425 288681005693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005694 putative substrate translocation pore; other site 288681005695 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 288681005696 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 288681005697 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 288681005698 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681005699 catalytic core [active] 288681005700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005701 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681005702 active site 288681005703 motif I; other site 288681005704 motif II; other site 288681005705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681005706 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 288681005707 alanine racemase; Reviewed; Region: alr; PRK00053 288681005708 active site 288681005709 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681005710 dimer interface [polypeptide binding]; other site 288681005711 substrate binding site [chemical binding]; other site 288681005712 catalytic residues [active] 288681005713 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681005714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005715 S-adenosylmethionine binding site [chemical binding]; other site 288681005716 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005717 Coenzyme A binding pocket [chemical binding]; other site 288681005718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005719 Coenzyme A binding pocket [chemical binding]; other site 288681005720 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 288681005721 glycosyltransferase, MGT family; Region: MGT; TIGR01426 288681005722 active site 288681005723 TDP-binding site; other site 288681005724 acceptor substrate-binding pocket; other site 288681005725 homodimer interface [polypeptide binding]; other site 288681005726 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681005727 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681005728 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681005729 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681005730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681005731 DNA-binding site [nucleotide binding]; DNA binding site 288681005732 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681005733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681005734 homodimer interface [polypeptide binding]; other site 288681005735 catalytic residue [active] 288681005736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005737 Coenzyme A binding pocket [chemical binding]; other site 288681005738 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681005739 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 288681005740 active site 288681005741 metal binding site [ion binding]; metal-binding site 288681005742 Src Homology 3 domain superfamily; Region: SH3; cl17036 288681005743 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288681005744 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681005745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005746 Coenzyme A binding pocket [chemical binding]; other site 288681005747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681005748 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 288681005749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005751 Coenzyme A binding pocket [chemical binding]; other site 288681005752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681005753 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681005754 Coenzyme A binding pocket [chemical binding]; other site 288681005755 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681005756 active site 288681005757 ATP binding site [chemical binding]; other site 288681005758 Phosphotransferase enzyme family; Region: APH; pfam01636 288681005759 substrate binding site [chemical binding]; other site 288681005760 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 288681005761 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 288681005762 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681005763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005764 S-adenosylmethionine binding site [chemical binding]; other site 288681005765 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 288681005766 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 288681005767 Potassium binding sites [ion binding]; other site 288681005768 Cesium cation binding sites [ion binding]; other site 288681005769 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 288681005770 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288681005771 ATP binding site [chemical binding]; other site 288681005772 putative Mg++ binding site [ion binding]; other site 288681005773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681005774 nucleotide binding region [chemical binding]; other site 288681005775 ATP-binding site [chemical binding]; other site 288681005776 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681005777 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288681005778 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681005779 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 288681005780 NADP binding site [chemical binding]; other site 288681005781 dimer interface [polypeptide binding]; other site 288681005782 RNA polymerase sigma factor; Provisional; Region: PRK12543 288681005783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681005784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681005785 DNA binding residues [nucleotide binding] 288681005786 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 288681005787 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 288681005788 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681005789 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 288681005790 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 288681005791 catalytic residues [active] 288681005792 dimer interface [polypeptide binding]; other site 288681005793 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 288681005794 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 288681005795 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 288681005796 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681005797 Protein of unknown function DUF58; Region: DUF58; pfam01882 288681005798 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681005799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681005800 Walker A motif; other site 288681005801 ATP binding site [chemical binding]; other site 288681005802 Walker B motif; other site 288681005803 arginine finger; other site 288681005804 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 288681005805 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 288681005806 [4Fe-4S] binding site [ion binding]; other site 288681005807 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288681005808 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288681005809 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 288681005810 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 288681005811 molybdopterin cofactor binding site; other site 288681005812 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 288681005813 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 288681005814 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 288681005815 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 288681005816 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681005817 ligand binding site [chemical binding]; other site 288681005818 flexible hinge region; other site 288681005819 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 288681005820 putative switch regulator; other site 288681005821 non-specific DNA interactions [nucleotide binding]; other site 288681005822 DNA binding site [nucleotide binding] 288681005823 sequence specific DNA binding site [nucleotide binding]; other site 288681005824 putative cAMP binding site [chemical binding]; other site 288681005825 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 288681005826 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681005827 FeS/SAM binding site; other site 288681005828 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288681005829 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 288681005830 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681005831 ATP binding site [chemical binding]; other site 288681005832 substrate interface [chemical binding]; other site 288681005833 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288681005834 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288681005835 dimer interface [polypeptide binding]; other site 288681005836 putative functional site; other site 288681005837 putative MPT binding site; other site 288681005838 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288681005839 MoaE homodimer interface [polypeptide binding]; other site 288681005840 MoaD interaction [polypeptide binding]; other site 288681005841 active site residues [active] 288681005842 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 288681005843 MoaE interaction surface [polypeptide binding]; other site 288681005844 MoeB interaction surface [polypeptide binding]; other site 288681005845 thiocarboxylated glycine; other site 288681005846 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 288681005847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681005848 putative substrate translocation pore; other site 288681005849 Predicted permeases [General function prediction only]; Region: COG0679 288681005850 precorrin-2 dehydrogenase; Validated; Region: PRK06719 288681005851 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 288681005852 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 288681005853 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 288681005854 putative active site [active] 288681005855 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 288681005856 putative active site [active] 288681005857 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 288681005858 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 288681005859 active site 288681005860 SAM binding site [chemical binding]; other site 288681005861 homodimer interface [polypeptide binding]; other site 288681005862 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 288681005863 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 288681005864 [2Fe-2S] cluster binding site [ion binding]; other site 288681005865 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 288681005866 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681005867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681005868 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 288681005869 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 288681005870 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 288681005871 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 288681005872 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 288681005873 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 288681005874 Fe binding site [ion binding]; other site 288681005875 Excalibur calcium-binding domain; Region: Excalibur; smart00894 288681005876 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 288681005877 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 288681005878 PGAP1-like protein; Region: PGAP1; pfam07819 288681005879 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 288681005880 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 288681005881 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 288681005882 active site flap/lid [active] 288681005883 nucleophilic elbow; other site 288681005884 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 288681005885 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 288681005886 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681005887 Zn2+ binding site [ion binding]; other site 288681005888 Mg2+ binding site [ion binding]; other site 288681005889 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 288681005890 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681005891 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681005892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681005893 ABC transporter; Region: ABC_tran_2; pfam12848 288681005894 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681005895 Bax inhibitor 1 like; Region: BaxI_1; cl17691 288681005896 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 288681005897 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 288681005898 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 288681005899 dimer interface [polypeptide binding]; other site 288681005900 ssDNA binding site [nucleotide binding]; other site 288681005901 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681005902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681005903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681005904 hypothetical protein; Provisional; Region: PRK06753 288681005905 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288681005906 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 288681005907 Virulence factor; Region: Virulence_fact; pfam13769 288681005908 HEAT repeats; Region: HEAT_2; pfam13646 288681005909 HEAT repeats; Region: HEAT_2; pfam13646 288681005910 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 288681005911 Protein of unknown function, DUF393; Region: DUF393; pfam04134 288681005912 Disulphide isomerase; Region: Disulph_isomer; pfam06491 288681005913 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 288681005914 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 288681005915 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 288681005916 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 288681005917 active site 288681005918 HIGH motif; other site 288681005919 KMSK motif region; other site 288681005920 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 288681005921 tRNA binding surface [nucleotide binding]; other site 288681005922 anticodon binding site; other site 288681005923 Methyltransferase domain; Region: Methyltransf_32; pfam13679 288681005924 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681005925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681005926 S-adenosylmethionine binding site [chemical binding]; other site 288681005927 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 288681005928 putative active site [active] 288681005929 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005930 binding surface 288681005931 TPR motif; other site 288681005932 TPR repeat; Region: TPR_11; pfam13414 288681005933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005934 binding surface 288681005935 TPR motif; other site 288681005936 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681005937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005938 binding surface 288681005939 TPR motif; other site 288681005940 TPR repeat; Region: TPR_11; pfam13414 288681005941 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005942 binding surface 288681005943 TPR motif; other site 288681005944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005945 TPR motif; other site 288681005946 TPR repeat; Region: TPR_11; pfam13414 288681005947 binding surface 288681005948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005949 binding surface 288681005950 TPR motif; other site 288681005951 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681005952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005953 binding surface 288681005954 TPR motif; other site 288681005955 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 288681005956 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288681005957 HIGH motif; other site 288681005958 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288681005959 active site 288681005960 KMSKS motif; other site 288681005961 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 288681005962 tRNA binding surface [nucleotide binding]; other site 288681005963 anticodon binding site; other site 288681005964 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681005965 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681005966 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 288681005967 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 288681005968 Zn binding site [ion binding]; other site 288681005969 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 288681005970 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681005971 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681005972 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681005973 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 288681005974 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 288681005975 Dimer interface [polypeptide binding]; other site 288681005976 anticodon binding site; other site 288681005977 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 288681005978 homodimer interface [polypeptide binding]; other site 288681005979 motif 1; other site 288681005980 motif 2; other site 288681005981 active site 288681005982 motif 3; other site 288681005983 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 288681005984 metal ion-dependent adhesion site (MIDAS); other site 288681005985 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 288681005986 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 288681005987 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 288681005988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681005989 Walker A motif; other site 288681005990 ATP binding site [chemical binding]; other site 288681005991 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 288681005992 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681005993 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681005994 active site 288681005995 ATP binding site [chemical binding]; other site 288681005996 substrate binding site [chemical binding]; other site 288681005997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681005998 binding surface 288681005999 TPR motif; other site 288681006000 TPR repeat; Region: TPR_11; pfam13414 288681006001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681006002 binding surface 288681006003 TPR motif; other site 288681006004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681006005 binding surface 288681006006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681006007 TPR motif; other site 288681006008 Protein of unknown function (DUF975); Region: DUF975; cl10504 288681006009 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681006010 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 288681006011 catalytic residues [active] 288681006012 catalytic nucleophile [active] 288681006013 Recombinase; Region: Recombinase; pfam07508 288681006014 Transposase; Region: DEDD_Tnp_IS110; pfam01548 288681006015 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 288681006016 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 288681006017 Protein of unknown function, DUF600; Region: DUF600; pfam04634 288681006018 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 288681006019 Na2 binding site [ion binding]; other site 288681006020 putative substrate binding site 1 [chemical binding]; other site 288681006021 Na binding site 1 [ion binding]; other site 288681006022 putative substrate binding site 2 [chemical binding]; other site 288681006023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681006024 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 288681006025 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 288681006026 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681006027 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681006028 motif II; other site 288681006029 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 288681006030 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288681006031 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 288681006032 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 288681006033 active site 288681006034 NAD binding site [chemical binding]; other site 288681006035 metal binding site [ion binding]; metal-binding site 288681006036 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 288681006037 aspartate racemase; Region: asp_race; TIGR00035 288681006038 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 288681006039 homodimer interaction site [polypeptide binding]; other site 288681006040 cofactor binding site; other site 288681006041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006042 Coenzyme A binding pocket [chemical binding]; other site 288681006043 hypothetical protein; Validated; Region: PRK06769 288681006044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681006045 active site 288681006046 motif I; other site 288681006047 motif II; other site 288681006048 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681006049 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006050 Coenzyme A binding pocket [chemical binding]; other site 288681006051 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 288681006052 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681006053 Walker A/P-loop; other site 288681006054 ATP binding site [chemical binding]; other site 288681006055 Q-loop/lid; other site 288681006056 ABC transporter signature motif; other site 288681006057 Walker B; other site 288681006058 D-loop; other site 288681006059 H-loop/switch region; other site 288681006060 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 288681006061 YpjP-like protein; Region: YpjP; pfam14005 288681006062 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681006063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681006064 motif II; other site 288681006065 hypothetical protein; Provisional; Region: PRK06724 288681006066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681006067 active site 288681006068 metal binding site [ion binding]; metal-binding site 288681006069 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 288681006070 Phosphotransferase enzyme family; Region: APH; pfam01636 288681006071 active site 288681006072 substrate binding site [chemical binding]; other site 288681006073 ATP binding site [chemical binding]; other site 288681006074 Peptidase family S41; Region: Peptidase_S41; pfam03572 288681006075 Active site serine [active] 288681006076 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681006077 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681006078 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 288681006079 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 288681006080 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 288681006081 thymidylate synthase; Region: thym_sym; TIGR03284 288681006082 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 288681006083 dimerization interface [polypeptide binding]; other site 288681006084 active site 288681006085 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 288681006086 folate binding site [chemical binding]; other site 288681006087 NADP+ binding site [chemical binding]; other site 288681006088 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 288681006089 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006090 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288681006091 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681006092 azoreductase; Reviewed; Region: PRK00170 288681006093 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288681006094 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 288681006095 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 288681006096 putative acyl-acceptor binding pocket; other site 288681006097 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 288681006098 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 288681006099 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 288681006100 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 288681006101 EDD domain protein, DegV family; Region: DegV; TIGR00762 288681006102 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 288681006103 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 288681006104 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 288681006105 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 288681006106 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 288681006107 Cu(I) binding site [ion binding]; other site 288681006108 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 288681006109 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 288681006110 putative dimer interface [polypeptide binding]; other site 288681006111 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 288681006112 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 288681006113 active site 288681006114 dimer interface [polypeptide binding]; other site 288681006115 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 288681006116 Ligand Binding Site [chemical binding]; other site 288681006117 Molecular Tunnel; other site 288681006118 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681006119 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681006120 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 288681006121 siderophore binding site; other site 288681006122 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 288681006123 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681006124 homodimer interface [polypeptide binding]; other site 288681006125 substrate-cofactor binding pocket; other site 288681006126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006127 catalytic residue [active] 288681006128 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 288681006129 FMN binding site [chemical binding]; other site 288681006130 dimer interface [polypeptide binding]; other site 288681006131 Isochorismatase family; Region: Isochorismatase; pfam00857 288681006132 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 288681006133 catalytic triad [active] 288681006134 conserved cis-peptide bond; other site 288681006135 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681006136 nudix motif; other site 288681006137 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 288681006138 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 288681006139 putative dimer interface [polypeptide binding]; other site 288681006140 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 288681006141 Mechanosensitive ion channel; Region: MS_channel; pfam00924 288681006142 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 288681006143 GAF domain; Region: GAF; pfam01590 288681006144 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681006145 Histidine kinase; Region: HisKA_3; pfam07730 288681006146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006147 ATP binding site [chemical binding]; other site 288681006148 Mg2+ binding site [ion binding]; other site 288681006149 G-X-G motif; other site 288681006150 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681006151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681006152 active site 288681006153 phosphorylation site [posttranslational modification] 288681006154 intermolecular recognition site; other site 288681006155 dimerization interface [polypeptide binding]; other site 288681006156 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681006157 DNA binding residues [nucleotide binding] 288681006158 dimerization interface [polypeptide binding]; other site 288681006159 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 288681006160 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 288681006161 putative active site [active] 288681006162 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 288681006163 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 288681006164 NAD binding site [chemical binding]; other site 288681006165 substrate binding site [chemical binding]; other site 288681006166 catalytic Zn binding site [ion binding]; other site 288681006167 tetramer interface [polypeptide binding]; other site 288681006168 structural Zn binding site [ion binding]; other site 288681006169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681006170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681006171 dimer interface [polypeptide binding]; other site 288681006172 conserved gate region; other site 288681006173 ABC-ATPase subunit interface; other site 288681006174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681006175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681006176 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681006177 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681006178 Erythromycin esterase; Region: Erythro_esteras; pfam05139 288681006179 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 288681006180 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 288681006181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681006182 active site 288681006183 Predicted flavoprotein [General function prediction only]; Region: COG0431 288681006184 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288681006185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006186 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006187 putative substrate translocation pore; other site 288681006188 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681006189 Uncharacterized conserved protein [Function unknown]; Region: COG1434 288681006190 putative active site [active] 288681006191 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 288681006192 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 288681006193 Walker A/P-loop; other site 288681006194 ATP binding site [chemical binding]; other site 288681006195 Q-loop/lid; other site 288681006196 ABC transporter signature motif; other site 288681006197 Walker B; other site 288681006198 D-loop; other site 288681006199 H-loop/switch region; other site 288681006200 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681006201 dimer interface [polypeptide binding]; other site 288681006202 conserved gate region; other site 288681006203 ABC-ATPase subunit interface; other site 288681006204 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 288681006205 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 288681006206 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 288681006207 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 288681006208 Protein of unknown function (DUF524); Region: DUF524; pfam04411 288681006209 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 288681006210 Helix-turn-helix domain; Region: HTH_17; cl17695 288681006211 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681006212 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681006213 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681006214 Transporter associated domain; Region: CorC_HlyC; smart01091 288681006215 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 288681006216 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681006217 NAD(P) binding site [chemical binding]; other site 288681006218 catalytic residues [active] 288681006219 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 288681006220 Histidine kinase N terminal; Region: HisK_N; pfam09385 288681006221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681006222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681006223 dimer interface [polypeptide binding]; other site 288681006224 phosphorylation site [posttranslational modification] 288681006225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006226 ATP binding site [chemical binding]; other site 288681006227 Mg2+ binding site [ion binding]; other site 288681006228 G-X-G motif; other site 288681006229 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 288681006230 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 288681006231 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 288681006232 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681006233 inhibitor-cofactor binding pocket; inhibition site 288681006234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006235 catalytic residue [active] 288681006236 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 288681006237 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 288681006238 acetylornithine deacetylase; Validated; Region: PRK06915 288681006239 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 288681006240 metal binding site [ion binding]; metal-binding site 288681006241 dimer interface [polypeptide binding]; other site 288681006242 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 288681006243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681006244 PAS fold; Region: PAS_4; pfam08448 288681006245 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 288681006246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681006247 Walker A motif; other site 288681006248 ATP binding site [chemical binding]; other site 288681006249 Walker B motif; other site 288681006250 arginine finger; other site 288681006251 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 288681006252 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 288681006253 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681006254 FeS/SAM binding site; other site 288681006255 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 288681006256 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 288681006257 toxin interface [polypeptide binding]; other site 288681006258 Zn binding site [ion binding]; other site 288681006259 hypothetical protein; Provisional; Region: PRK13672 288681006260 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 288681006261 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 288681006262 YozD-like protein; Region: YozD; pfam14162 288681006263 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288681006264 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288681006265 active site 288681006266 ATP binding site [chemical binding]; other site 288681006267 substrate binding site [chemical binding]; other site 288681006268 activation loop (A-loop); other site 288681006269 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 288681006270 SpoOM protein; Region: Spo0M; pfam07070 288681006271 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 288681006272 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 288681006273 active site 288681006274 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 288681006275 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 288681006276 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681006277 catalytic residues [active] 288681006278 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 288681006279 CHRD domain; Region: CHRD; pfam07452 288681006280 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 288681006281 C1q domain; Region: C1q; cl17543 288681006282 C1q domain; Region: C1q; cl17543 288681006283 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 288681006284 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 288681006285 YolD-like protein; Region: YolD; pfam08863 288681006286 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681006287 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 288681006288 Transglycosylase; Region: Transgly; pfam00912 288681006289 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681006290 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681006291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681006293 putative substrate translocation pore; other site 288681006294 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 288681006295 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 288681006296 dimer interface [polypeptide binding]; other site 288681006297 Citrate synthase; Region: Citrate_synt; pfam00285 288681006298 active site 288681006299 coenzyme A binding site [chemical binding]; other site 288681006300 citrylCoA binding site [chemical binding]; other site 288681006301 oxalacetate/citrate binding site [chemical binding]; other site 288681006302 catalytic triad [active] 288681006303 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 288681006304 2-methylcitrate dehydratase; Region: prpD; TIGR02330 288681006305 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288681006306 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 288681006307 tetramer interface [polypeptide binding]; other site 288681006308 active site 288681006309 Mg2+/Mn2+ binding site [ion binding]; other site 288681006310 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288681006311 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681006312 active site 288681006313 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 288681006314 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 288681006315 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 288681006316 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288681006317 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 288681006318 tetrameric interface [polypeptide binding]; other site 288681006319 NAD binding site [chemical binding]; other site 288681006320 catalytic residues [active] 288681006321 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 288681006322 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 288681006323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681006324 substrate binding site [chemical binding]; other site 288681006325 oxyanion hole (OAH) forming residues; other site 288681006326 trimer interface [polypeptide binding]; other site 288681006327 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 288681006328 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 288681006329 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 288681006330 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 288681006331 active site 288681006332 metal binding site [ion binding]; metal-binding site 288681006333 DNA binding site [nucleotide binding] 288681006334 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 288681006335 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 288681006336 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 288681006337 Walker A/P-loop; other site 288681006338 ATP binding site [chemical binding]; other site 288681006339 Q-loop/lid; other site 288681006340 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 288681006341 ABC transporter signature motif; other site 288681006342 Walker B; other site 288681006343 D-loop; other site 288681006344 H-loop/switch region; other site 288681006345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681006346 dimerization interface [polypeptide binding]; other site 288681006347 putative DNA binding site [nucleotide binding]; other site 288681006348 putative Zn2+ binding site [ion binding]; other site 288681006349 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 288681006350 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 288681006351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006352 putative substrate translocation pore; other site 288681006353 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 288681006354 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 288681006355 putative NAD(P) binding site [chemical binding]; other site 288681006356 active site 288681006357 isochorismate synthase DhbC; Validated; Region: PRK06923 288681006358 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 288681006359 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 288681006360 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 288681006361 acyl-activating enzyme (AAE) consensus motif; other site 288681006362 active site 288681006363 AMP binding site [chemical binding]; other site 288681006364 substrate binding site [chemical binding]; other site 288681006365 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 288681006366 hydrophobic substrate binding pocket; other site 288681006367 Isochorismatase family; Region: Isochorismatase; pfam00857 288681006368 active site 288681006369 conserved cis-peptide bond; other site 288681006370 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 288681006371 Condensation domain; Region: Condensation; pfam00668 288681006372 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 288681006373 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 288681006374 acyl-activating enzyme (AAE) consensus motif; other site 288681006375 AMP binding site [chemical binding]; other site 288681006376 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681006377 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 288681006378 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 288681006379 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 288681006380 acyl-activating enzyme (AAE) consensus motif; other site 288681006381 AMP binding site [chemical binding]; other site 288681006382 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 288681006383 MbtH-like protein; Region: MbtH; cl01279 288681006384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006385 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681006386 putative substrate translocation pore; other site 288681006387 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 288681006388 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 288681006389 histone-like DNA-binding protein HU; Region: HU; cd13831 288681006390 dimer interface [polypeptide binding]; other site 288681006391 DNA binding site [nucleotide binding] 288681006392 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 288681006393 DinB family; Region: DinB; cl17821 288681006394 DinB superfamily; Region: DinB_2; pfam12867 288681006395 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 288681006396 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 288681006397 active site 288681006398 catalytic triad [active] 288681006399 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681006400 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681006401 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 288681006402 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681006403 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681006404 RNA binding surface [nucleotide binding]; other site 288681006405 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 288681006406 probable active site [active] 288681006407 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 288681006408 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 288681006409 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 288681006410 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 288681006411 active site 288681006412 dimer interface [polypeptide binding]; other site 288681006413 motif 1; other site 288681006414 motif 2; other site 288681006415 motif 3; other site 288681006416 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 288681006417 anticodon binding site; other site 288681006418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681006419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681006420 Walker A/P-loop; other site 288681006421 ATP binding site [chemical binding]; other site 288681006422 Q-loop/lid; other site 288681006423 ABC transporter signature motif; other site 288681006424 Walker B; other site 288681006425 D-loop; other site 288681006426 H-loop/switch region; other site 288681006427 FtsX-like permease family; Region: FtsX; pfam02687 288681006428 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681006429 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 288681006430 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681006433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681006434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681006435 dimer interface [polypeptide binding]; other site 288681006436 conserved gate region; other site 288681006437 ABC-ATPase subunit interface; other site 288681006438 pyruvate oxidase; Provisional; Region: PRK08611 288681006439 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 288681006440 PYR/PP interface [polypeptide binding]; other site 288681006441 dimer interface [polypeptide binding]; other site 288681006442 tetramer interface [polypeptide binding]; other site 288681006443 TPP binding site [chemical binding]; other site 288681006444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681006445 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 288681006446 TPP-binding site [chemical binding]; other site 288681006447 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 288681006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006449 S-adenosylmethionine binding site [chemical binding]; other site 288681006450 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681006451 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 288681006452 active site 288681006453 dimerization interface [polypeptide binding]; other site 288681006454 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 288681006455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 288681006456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681006457 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006458 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681006459 MMPL family; Region: MMPL; pfam03176 288681006460 MMPL family; Region: MMPL; pfam03176 288681006461 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 288681006462 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 288681006463 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 288681006464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006465 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681006466 Coenzyme A binding pocket [chemical binding]; other site 288681006467 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681006468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006469 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681006470 Coenzyme A binding pocket [chemical binding]; other site 288681006471 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 288681006472 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 288681006473 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 288681006474 putative acetyltransferase YhhY; Provisional; Region: PRK10140 288681006475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006476 Coenzyme A binding pocket [chemical binding]; other site 288681006477 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681006478 EamA-like transporter family; Region: EamA; pfam00892 288681006479 EamA-like transporter family; Region: EamA; pfam00892 288681006480 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681006481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681006482 non-specific DNA binding site [nucleotide binding]; other site 288681006483 salt bridge; other site 288681006484 sequence-specific DNA binding site [nucleotide binding]; other site 288681006485 Cupin domain; Region: Cupin_2; pfam07883 288681006486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681006487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681006488 protoporphyrinogen oxidase; Provisional; Region: PRK12416 288681006489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681006490 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 288681006491 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681006492 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681006493 Cold-inducible protein YdjO; Region: YdjO; pfam14169 288681006494 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288681006495 DNA-binding site [nucleotide binding]; DNA binding site 288681006496 RNA-binding motif; other site 288681006497 CAAX protease self-immunity; Region: Abi; pfam02517 288681006498 AAA domain; Region: AAA_17; pfam13207 288681006499 AAA domain; Region: AAA_18; pfam13238 288681006500 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 288681006501 active site 288681006502 metal binding site [ion binding]; metal-binding site 288681006503 hypothetical protein; Provisional; Region: PRK06770 288681006504 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681006505 MarR family; Region: MarR_2; cl17246 288681006506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006507 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681006508 putative substrate translocation pore; other site 288681006509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681006510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681006511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681006512 dimerization interface [polypeptide binding]; other site 288681006513 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 288681006514 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 288681006515 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 288681006516 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 288681006517 active site 288681006518 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 288681006519 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 288681006520 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681006521 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681006522 dimerization interface [polypeptide binding]; other site 288681006523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 288681006524 MOSC domain; Region: MOSC; pfam03473 288681006525 3-alpha domain; Region: 3-alpha; pfam03475 288681006526 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006527 Coenzyme A binding pocket [chemical binding]; other site 288681006528 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 288681006529 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681006530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681006531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681006532 Walker A/P-loop; other site 288681006533 ATP binding site [chemical binding]; other site 288681006534 Q-loop/lid; other site 288681006535 ABC transporter signature motif; other site 288681006536 Walker B; other site 288681006537 D-loop; other site 288681006538 H-loop/switch region; other site 288681006539 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681006540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681006541 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 288681006542 Walker A/P-loop; other site 288681006543 ATP binding site [chemical binding]; other site 288681006544 Q-loop/lid; other site 288681006545 ABC transporter signature motif; other site 288681006546 Walker B; other site 288681006547 D-loop; other site 288681006548 H-loop/switch region; other site 288681006549 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681006550 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 288681006551 active site 288681006552 metal binding site [ion binding]; metal-binding site 288681006553 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 288681006554 LysE type translocator; Region: LysE; cl00565 288681006555 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681006556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681006557 non-specific DNA binding site [nucleotide binding]; other site 288681006558 salt bridge; other site 288681006559 sequence-specific DNA binding site [nucleotide binding]; other site 288681006560 Cupin domain; Region: Cupin_2; pfam07883 288681006561 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 288681006562 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 288681006563 BclB C-terminal domain; Region: exospore_TM; TIGR03721 288681006564 Cupin; Region: Cupin_1; smart00835 288681006565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681006566 Zn2+ binding site [ion binding]; other site 288681006567 Mg2+ binding site [ion binding]; other site 288681006568 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 288681006569 metal binding triad [ion binding]; metal-binding site 288681006570 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 288681006571 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 288681006572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681006573 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 288681006574 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681006575 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 288681006576 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 288681006577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006578 S-adenosylmethionine binding site [chemical binding]; other site 288681006579 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 288681006580 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 288681006581 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 288681006582 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 288681006583 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 288681006584 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681006585 active site 288681006586 P-loop; other site 288681006587 phosphorylation site [posttranslational modification] 288681006588 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 288681006589 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681006590 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 288681006591 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681006592 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681006593 nucleotide binding site [chemical binding]; other site 288681006594 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 288681006595 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 288681006596 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 288681006597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681006598 catalytic residue [active] 288681006599 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 288681006600 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 288681006601 tetramer interface [polypeptide binding]; other site 288681006602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006603 catalytic residue [active] 288681006604 Uncharacterized conserved protein [Function unknown]; Region: COG3339 288681006605 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681006606 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 288681006607 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681006608 ATP binding site [chemical binding]; other site 288681006609 Mg++ binding site [ion binding]; other site 288681006610 motif III; other site 288681006611 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681006612 nucleotide binding region [chemical binding]; other site 288681006613 ATP-binding site [chemical binding]; other site 288681006614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681006616 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006618 putative substrate translocation pore; other site 288681006619 FtsX-like permease family; Region: FtsX; pfam02687 288681006620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681006621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681006622 Walker A/P-loop; other site 288681006623 ATP binding site [chemical binding]; other site 288681006624 Q-loop/lid; other site 288681006625 ABC transporter signature motif; other site 288681006626 Walker B; other site 288681006627 D-loop; other site 288681006628 H-loop/switch region; other site 288681006629 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681006630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006631 S-adenosylmethionine binding site [chemical binding]; other site 288681006632 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 288681006633 dimer interface [polypeptide binding]; other site 288681006634 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 288681006635 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 288681006636 dimer interface [polypeptide binding]; other site 288681006637 PYR/PP interface [polypeptide binding]; other site 288681006638 TPP binding site [chemical binding]; other site 288681006639 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681006640 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 288681006641 TPP-binding site [chemical binding]; other site 288681006642 dimer interface [polypeptide binding]; other site 288681006643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 288681006644 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681006645 putative DNA binding site [nucleotide binding]; other site 288681006646 putative Zn2+ binding site [ion binding]; other site 288681006647 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681006648 catalytic core [active] 288681006649 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 288681006650 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 288681006651 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 288681006652 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 288681006653 metal binding site [ion binding]; metal-binding site 288681006654 dimer interface [polypeptide binding]; other site 288681006655 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 288681006656 active site 288681006657 catalytic triad [active] 288681006658 oxyanion hole [active] 288681006659 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 288681006660 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681006661 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681006662 DNA binding residues [nucleotide binding] 288681006663 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 288681006664 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006665 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681006666 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681006667 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006668 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681006669 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681006670 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 288681006671 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681006672 active site 288681006673 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681006674 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681006675 DNA binding site [nucleotide binding] 288681006676 domain linker motif; other site 288681006677 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681006678 dimerization interface [polypeptide binding]; other site 288681006679 ligand binding site [chemical binding]; other site 288681006680 polyol permease family; Region: 2A0118; TIGR00897 288681006681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006682 putative substrate translocation pore; other site 288681006683 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681006684 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681006685 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288681006686 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681006687 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681006688 substrate binding site [chemical binding]; other site 288681006689 ATP binding site [chemical binding]; other site 288681006690 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288681006691 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 288681006692 tetrameric interface [polypeptide binding]; other site 288681006693 NAD binding site [chemical binding]; other site 288681006694 catalytic residues [active] 288681006695 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 288681006696 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681006697 PYR/PP interface [polypeptide binding]; other site 288681006698 dimer interface [polypeptide binding]; other site 288681006699 TPP binding site [chemical binding]; other site 288681006700 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681006701 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 288681006702 TPP-binding site; other site 288681006703 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681006704 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 288681006705 Metal-binding active site; metal-binding site 288681006706 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681006707 intersubunit interface [polypeptide binding]; other site 288681006708 active site 288681006709 zinc binding site [ion binding]; other site 288681006710 Na+ binding site [ion binding]; other site 288681006711 KduI/IolB family; Region: KduI; pfam04962 288681006712 DinB superfamily; Region: DinB_2; pfam12867 288681006713 DinB superfamily; Region: DinB_2; pfam12867 288681006714 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681006715 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 288681006716 active site 288681006717 metal binding site [ion binding]; metal-binding site 288681006718 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681006719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681006720 TPR motif; other site 288681006721 binding surface 288681006722 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681006723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681006724 salt bridge; other site 288681006725 non-specific DNA binding site [nucleotide binding]; other site 288681006726 sequence-specific DNA binding site [nucleotide binding]; other site 288681006727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681006728 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681006729 Probable transposase; Region: OrfB_IS605; pfam01385 288681006730 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681006731 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 288681006732 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288681006733 S-layer homology domain; Region: SLH; pfam00395 288681006734 S-layer homology domain; Region: SLH; pfam00395 288681006735 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 288681006736 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 288681006737 active site 288681006738 metal binding site [ion binding]; metal-binding site 288681006739 beta-channel forming cytolysin; Region: hlyII; TIGR01002 288681006740 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006741 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681006742 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681006743 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681006744 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681006745 PAS fold; Region: PAS_4; pfam08448 288681006746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681006747 putative active site [active] 288681006748 heme pocket [chemical binding]; other site 288681006749 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681006750 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681006751 metal binding site [ion binding]; metal-binding site 288681006752 active site 288681006753 I-site; other site 288681006754 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681006755 Tar ligand binding domain homologue; Region: TarH; pfam02203 288681006756 Cache domain; Region: Cache_1; pfam02743 288681006757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681006758 dimerization interface [polypeptide binding]; other site 288681006759 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681006760 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681006761 dimer interface [polypeptide binding]; other site 288681006762 putative CheW interface [polypeptide binding]; other site 288681006763 Homeodomain-like domain; Region: HTH_23; cl17451 288681006764 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 288681006765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681006766 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 288681006767 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681006768 active site residue [active] 288681006769 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681006770 active site residue [active] 288681006771 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681006772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681006773 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681006774 Walker A/P-loop; other site 288681006775 ATP binding site [chemical binding]; other site 288681006776 Q-loop/lid; other site 288681006777 ABC transporter signature motif; other site 288681006778 Walker B; other site 288681006779 D-loop; other site 288681006780 H-loop/switch region; other site 288681006781 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 288681006782 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 288681006783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681006784 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681006785 Protein of unknown function (DUF523); Region: DUF523; pfam04463 288681006786 Uncharacterized conserved protein [Function unknown]; Region: COG3272 288681006787 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 288681006788 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681006789 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 288681006790 FAD binding site [chemical binding]; other site 288681006791 homotetramer interface [polypeptide binding]; other site 288681006792 substrate binding pocket [chemical binding]; other site 288681006793 catalytic base [active] 288681006794 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 288681006795 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681006796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288681006797 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 288681006798 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288681006799 carboxyltransferase (CT) interaction site; other site 288681006800 biotinylation site [posttranslational modification]; other site 288681006801 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 288681006802 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 288681006803 active site 288681006804 catalytic residues [active] 288681006805 metal binding site [ion binding]; metal-binding site 288681006806 enoyl-CoA hydratase; Provisional; Region: PRK07657 288681006807 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681006808 substrate binding site [chemical binding]; other site 288681006809 oxyanion hole (OAH) forming residues; other site 288681006810 trimer interface [polypeptide binding]; other site 288681006811 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 288681006812 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 288681006813 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 288681006814 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 288681006815 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 288681006816 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 288681006817 acyl-activating enzyme (AAE) consensus motif; other site 288681006818 putative AMP binding site [chemical binding]; other site 288681006819 putative active site [active] 288681006820 putative CoA binding site [chemical binding]; other site 288681006821 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681006822 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006823 Coenzyme A binding pocket [chemical binding]; other site 288681006824 hypothetical protein; Provisional; Region: PRK08233 288681006825 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 288681006826 active site 288681006827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681006828 DinB family; Region: DinB; cl17821 288681006829 DinB superfamily; Region: DinB_2; pfam12867 288681006830 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681006831 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681006832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681006833 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681006834 dimer interface [polypeptide binding]; other site 288681006835 phosphorylation site [posttranslational modification] 288681006836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006837 ATP binding site [chemical binding]; other site 288681006838 Mg2+ binding site [ion binding]; other site 288681006839 G-X-G motif; other site 288681006840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681006841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681006842 active site 288681006843 phosphorylation site [posttranslational modification] 288681006844 intermolecular recognition site; other site 288681006845 dimerization interface [polypeptide binding]; other site 288681006846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681006847 DNA binding site [nucleotide binding] 288681006848 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681006849 Zn2+ binding site [ion binding]; other site 288681006850 Mg2+ binding site [ion binding]; other site 288681006851 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 288681006852 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 288681006853 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681006854 NAD binding site [chemical binding]; other site 288681006855 substrate binding site [chemical binding]; other site 288681006856 putative active site [active] 288681006857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681006858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006859 Coenzyme A binding pocket [chemical binding]; other site 288681006860 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681006861 Coenzyme A binding pocket [chemical binding]; other site 288681006862 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681006863 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681006864 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681006865 active site 288681006866 Zn binding site [ion binding]; other site 288681006867 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 288681006868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 288681006869 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 288681006870 putative hydrophobic ligand binding site [chemical binding]; other site 288681006871 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681006872 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681006873 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681006874 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681006875 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681006876 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681006877 DNA binding residues [nucleotide binding] 288681006878 drug binding residues [chemical binding]; other site 288681006879 dimer interface [polypeptide binding]; other site 288681006880 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 288681006881 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006883 putative substrate translocation pore; other site 288681006884 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681006885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006886 S-adenosylmethionine binding site [chemical binding]; other site 288681006887 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 288681006888 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681006889 serine/threonine protein kinase; Provisional; Region: PRK14879 288681006890 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 288681006891 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 288681006892 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681006893 active site 288681006894 ATP binding site [chemical binding]; other site 288681006895 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 288681006896 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681006897 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 288681006898 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 288681006899 active site 288681006900 Zn binding site [ion binding]; other site 288681006901 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 288681006902 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681006903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681006904 DNA-binding site [nucleotide binding]; DNA binding site 288681006905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681006906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006907 homodimer interface [polypeptide binding]; other site 288681006908 catalytic residue [active] 288681006909 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681006910 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 288681006911 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 288681006912 putative NAD(P) binding site [chemical binding]; other site 288681006913 Predicted membrane protein [Function unknown]; Region: COG2323 288681006914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006915 S-adenosylmethionine binding site [chemical binding]; other site 288681006916 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681006917 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681006918 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 288681006919 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681006920 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681006921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681006922 S-adenosylmethionine binding site [chemical binding]; other site 288681006923 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 288681006924 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 288681006925 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 288681006926 active site 288681006927 HIGH motif; other site 288681006928 KMSKS motif; other site 288681006929 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681006930 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 288681006931 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681006932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681006933 active site 288681006934 phosphorylation site [posttranslational modification] 288681006935 intermolecular recognition site; other site 288681006936 dimerization interface [polypeptide binding]; other site 288681006937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681006938 DNA binding site [nucleotide binding] 288681006939 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681006940 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 288681006941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681006942 ATP binding site [chemical binding]; other site 288681006943 Mg2+ binding site [ion binding]; other site 288681006944 G-X-G motif; other site 288681006945 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 288681006946 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681006947 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681006948 ABC transporter; Region: ABC_tran_2; pfam12848 288681006949 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681006950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681006951 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681006952 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 288681006953 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681006954 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681006955 Walker A/P-loop; other site 288681006956 ATP binding site [chemical binding]; other site 288681006957 Q-loop/lid; other site 288681006958 ABC transporter signature motif; other site 288681006959 Walker B; other site 288681006960 D-loop; other site 288681006961 H-loop/switch region; other site 288681006962 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681006963 FtsX-like permease family; Region: FtsX; pfam02687 288681006964 hypothetical protein; Provisional; Region: PRK06760 288681006965 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 288681006966 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 288681006967 homoserine dehydrogenase; Validated; Region: PRK06813 288681006968 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 288681006969 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288681006970 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681006971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681006972 DNA-binding site [nucleotide binding]; DNA binding site 288681006973 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681006974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681006975 homodimer interface [polypeptide binding]; other site 288681006976 catalytic residue [active] 288681006977 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 288681006978 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 288681006979 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288681006980 Putative transcription activator [Transcription]; Region: TenA; COG0819 288681006981 Septum formation initiator; Region: DivIC; cl17659 288681006982 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 288681006983 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 288681006984 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 288681006985 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 288681006986 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 288681006987 Protein of unknown function; Region: DUF3658; pfam12395 288681006988 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 288681006989 Cytochrome P450; Region: p450; cl12078 288681006990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006991 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681006992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681006993 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 288681006994 trimer interface [polypeptide binding]; other site 288681006995 active site 288681006996 substrate binding site [chemical binding]; other site 288681006997 CoA binding site [chemical binding]; other site 288681006998 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681006999 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681007000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 288681007001 Cytochrome P450; Region: p450; cl12078 288681007002 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 288681007003 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007004 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681007005 active site 288681007006 motif I; other site 288681007007 motif II; other site 288681007008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007009 PAS domain S-box; Region: sensory_box; TIGR00229 288681007010 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681007011 putative active site [active] 288681007012 heme pocket [chemical binding]; other site 288681007013 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 288681007014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681007015 dimer interface [polypeptide binding]; other site 288681007016 phosphorylation site [posttranslational modification] 288681007017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007018 ATP binding site [chemical binding]; other site 288681007019 Mg2+ binding site [ion binding]; other site 288681007020 G-X-G motif; other site 288681007021 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681007022 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681007023 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681007024 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681007025 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 288681007026 glycosyltransferase, MGT family; Region: MGT; TIGR01426 288681007027 active site 288681007028 TDP-binding site; other site 288681007029 acceptor substrate-binding pocket; other site 288681007030 homodimer interface [polypeptide binding]; other site 288681007031 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 288681007032 aspartate racemase; Region: asp_race; TIGR00035 288681007033 hypothetical protein; Provisional; Region: PRK13661 288681007034 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 288681007035 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288681007036 Walker A/P-loop; other site 288681007037 ATP binding site [chemical binding]; other site 288681007038 Q-loop/lid; other site 288681007039 ABC transporter signature motif; other site 288681007040 Walker B; other site 288681007041 D-loop; other site 288681007042 H-loop/switch region; other site 288681007043 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 288681007044 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288681007045 Walker A/P-loop; other site 288681007046 ATP binding site [chemical binding]; other site 288681007047 Q-loop/lid; other site 288681007048 ABC transporter signature motif; other site 288681007049 Walker B; other site 288681007050 D-loop; other site 288681007051 H-loop/switch region; other site 288681007052 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 288681007053 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 288681007054 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681007055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681007056 dimer interface [polypeptide binding]; other site 288681007057 phosphorylation site [posttranslational modification] 288681007058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007059 ATP binding site [chemical binding]; other site 288681007060 Mg2+ binding site [ion binding]; other site 288681007061 G-X-G motif; other site 288681007062 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007063 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 288681007064 active site 288681007065 ATP binding site [chemical binding]; other site 288681007066 substrate binding site [chemical binding]; other site 288681007067 activation loop (A-loop); other site 288681007068 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 288681007069 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681007070 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 288681007071 NAD(P) binding site [chemical binding]; other site 288681007072 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681007073 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 288681007074 active site 288681007075 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681007076 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681007077 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681007078 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 288681007079 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 288681007080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007081 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681007082 putative substrate translocation pore; other site 288681007083 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681007084 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681007085 putative acetyltransferase; Provisional; Region: PRK03624 288681007086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007087 Coenzyme A binding pocket [chemical binding]; other site 288681007088 VanZ like family; Region: VanZ; pfam04892 288681007089 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 288681007090 EDD domain protein, DegV family; Region: DegV; TIGR00762 288681007091 Putative amidotransferase; Region: DUF4066; pfam13278 288681007092 conserved cys residue [active] 288681007093 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 288681007094 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 288681007095 Predicted transcriptional regulator [Transcription]; Region: COG2378 288681007096 HTH domain; Region: HTH_11; pfam08279 288681007097 WYL domain; Region: WYL; pfam13280 288681007098 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 288681007099 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 288681007100 conserved cys residue [active] 288681007101 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681007102 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681007103 Walker A/P-loop; other site 288681007104 ATP binding site [chemical binding]; other site 288681007105 Q-loop/lid; other site 288681007106 ABC transporter signature motif; other site 288681007107 Walker B; other site 288681007108 D-loop; other site 288681007109 H-loop/switch region; other site 288681007110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 288681007111 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681007112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 288681007113 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681007114 Penicillinase repressor; Region: Pencillinase_R; pfam03965 288681007115 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 288681007116 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681007117 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681007118 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_39; cd04699 288681007119 nudix motif; other site 288681007120 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg1; cd04777 288681007121 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681007122 DNA binding residues [nucleotide binding] 288681007123 putative dimer interface [polypeptide binding]; other site 288681007124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007125 S-adenosylmethionine binding site [chemical binding]; other site 288681007126 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681007127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007129 Coenzyme A binding pocket [chemical binding]; other site 288681007130 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 288681007131 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681007132 active site 288681007133 catalytic site [active] 288681007134 metal binding site [ion binding]; metal-binding site 288681007135 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 288681007136 active site 288681007137 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 288681007138 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681007139 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681007140 DNA-binding site [nucleotide binding]; DNA binding site 288681007141 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007143 homodimer interface [polypeptide binding]; other site 288681007144 catalytic residue [active] 288681007145 EamA-like transporter family; Region: EamA; pfam00892 288681007146 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681007147 EamA-like transporter family; Region: EamA; pfam00892 288681007148 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 288681007149 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681007150 Coenzyme A binding pocket [chemical binding]; other site 288681007151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 288681007152 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681007153 nudix motif; other site 288681007154 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 288681007155 Beta-lactamase; Region: Beta-lactamase; cl17358 288681007156 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681007157 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681007158 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 288681007159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 288681007160 putative substrate translocation pore; other site 288681007161 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681007162 nudix motif; other site 288681007163 DNA polymerase III subunit beta; Validated; Region: PRK06673 288681007164 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 288681007165 putative DNA binding surface [nucleotide binding]; other site 288681007166 dimer interface [polypeptide binding]; other site 288681007167 beta-clamp/clamp loader binding surface; other site 288681007168 beta-clamp/translesion DNA polymerase binding surface; other site 288681007169 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681007170 putative active site [active] 288681007171 nucleotide binding site [chemical binding]; other site 288681007172 nudix motif; other site 288681007173 putative metal binding site [ion binding]; other site 288681007174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681007175 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 288681007176 homotrimer interaction site [polypeptide binding]; other site 288681007177 putative active site [active] 288681007178 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 288681007179 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 288681007180 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 288681007181 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 288681007182 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 288681007183 YxiJ-like protein; Region: YxiJ; pfam14176 288681007184 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 288681007185 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 288681007186 active site 288681007187 nucleophile elbow; other site 288681007188 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 288681007189 pentamer interface [polypeptide binding]; other site 288681007190 dodecaamer interface [polypeptide binding]; other site 288681007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007192 Coenzyme A binding pocket [chemical binding]; other site 288681007193 metal-dependent hydrolase; Provisional; Region: PRK13291 288681007194 DinB superfamily; Region: DinB_2; pfam12867 288681007195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007196 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681007197 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 288681007198 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 288681007199 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288681007200 GIY-YIG motif/motif A; other site 288681007201 active site 288681007202 catalytic site [active] 288681007203 putative DNA binding site [nucleotide binding]; other site 288681007204 metal binding site [ion binding]; metal-binding site 288681007205 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007206 Coenzyme A binding pocket [chemical binding]; other site 288681007207 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 288681007208 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 288681007209 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 288681007210 active site 288681007211 ATP binding site [chemical binding]; other site 288681007212 substrate binding site [chemical binding]; other site 288681007213 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 288681007214 nudix motif; other site 288681007215 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681007216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681007217 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 288681007218 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 288681007219 MepB protein; Region: MepB; pfam08877 288681007220 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 288681007221 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007222 motif II; other site 288681007223 DinB superfamily; Region: DinB_2; pfam12867 288681007224 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 288681007225 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 288681007226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681007227 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 288681007228 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681007229 active site 288681007230 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 288681007231 carbohydrate binding site [chemical binding]; other site 288681007232 pullulanase, type I; Region: pulA_typeI; TIGR02104 288681007233 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 288681007234 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 288681007235 Ca binding site [ion binding]; other site 288681007236 active site 288681007237 catalytic site [active] 288681007238 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 288681007239 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681007240 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681007241 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681007242 active site 288681007243 Zn binding site [ion binding]; other site 288681007244 Putative zinc-finger; Region: zf-HC2; pfam13490 288681007245 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 288681007246 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 288681007247 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681007248 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681007249 DNA binding residues [nucleotide binding] 288681007250 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681007251 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681007252 active site 288681007253 metal binding site [ion binding]; metal-binding site 288681007254 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681007255 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 288681007256 SecY translocase; Region: SecY; pfam00344 288681007257 hypothetical protein; Validated; Region: PRK06672 288681007258 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681007259 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681007260 DnaA N-terminal domain; Region: DnaA_N; pfam11638 288681007261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681007262 EamA-like transporter family; Region: EamA; pfam00892 288681007263 EamA-like transporter family; Region: EamA; pfam00892 288681007264 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681007265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681007266 DNA-binding site [nucleotide binding]; DNA binding site 288681007267 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007268 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007269 homodimer interface [polypeptide binding]; other site 288681007270 catalytic residue [active] 288681007271 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681007272 TAP-like protein; Region: Abhydrolase_4; pfam08386 288681007273 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 288681007274 Mg binding site [ion binding]; other site 288681007275 nucleotide binding site [chemical binding]; other site 288681007276 putative protofilament interface [polypeptide binding]; other site 288681007277 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 288681007278 Predicted membrane protein [Function unknown]; Region: COG4129 288681007279 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 288681007280 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681007281 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 288681007282 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 288681007283 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 288681007284 germination protein YpeB; Region: spore_YpeB; TIGR02889 288681007285 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 288681007286 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 288681007287 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681007288 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 288681007289 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681007290 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681007291 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 288681007292 arylformamidase; Region: trp_arylform; TIGR03035 288681007293 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 288681007294 kynureninase; Region: kynureninase; TIGR01814 288681007295 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681007296 catalytic residue [active] 288681007297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681007298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681007299 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681007300 nudix motif; other site 288681007301 N-acetyltransferase; Region: Acetyltransf_2; cl00949 288681007302 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 288681007303 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 288681007304 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 288681007305 GAF domain; Region: GAF; pfam01590 288681007306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007307 Walker A motif; other site 288681007308 ATP binding site [chemical binding]; other site 288681007309 Walker B motif; other site 288681007310 arginine finger; other site 288681007311 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 288681007312 NIPSNAP; Region: NIPSNAP; pfam07978 288681007313 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681007314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007315 Coenzyme A binding pocket [chemical binding]; other site 288681007316 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681007317 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 288681007318 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288681007319 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 288681007320 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 288681007321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681007322 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681007323 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 288681007324 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288681007325 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681007326 E3 interaction surface; other site 288681007327 lipoyl attachment site [posttranslational modification]; other site 288681007328 e3 binding domain; Region: E3_binding; pfam02817 288681007329 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288681007330 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288681007331 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288681007332 alpha subunit interface [polypeptide binding]; other site 288681007333 TPP binding site [chemical binding]; other site 288681007334 heterodimer interface [polypeptide binding]; other site 288681007335 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681007336 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 288681007337 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288681007338 tetramer interface [polypeptide binding]; other site 288681007339 TPP-binding site [chemical binding]; other site 288681007340 heterodimer interface [polypeptide binding]; other site 288681007341 phosphorylation loop region [posttranslational modification] 288681007342 DinB superfamily; Region: DinB_2; pfam12867 288681007343 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 288681007344 short chain dehydrogenase; Provisional; Region: PRK06914 288681007345 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 288681007346 NADP binding site [chemical binding]; other site 288681007347 active site 288681007348 steroid binding site; other site 288681007349 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 288681007350 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 288681007351 AAA domain; Region: AAA_18; pfam13238 288681007352 active site 288681007353 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 288681007354 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 288681007355 nudix motif; other site 288681007356 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 288681007357 Protein phosphatase 2C; Region: PP2C_2; pfam13672 288681007358 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 288681007359 nucleotide binding site/active site [active] 288681007360 HIT family signature motif; other site 288681007361 catalytic residue [active] 288681007362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681007363 dimer interface [polypeptide binding]; other site 288681007364 conserved gate region; other site 288681007365 putative PBP binding loops; other site 288681007366 ABC-ATPase subunit interface; other site 288681007367 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 288681007368 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 288681007369 Walker A/P-loop; other site 288681007370 ATP binding site [chemical binding]; other site 288681007371 Q-loop/lid; other site 288681007372 ABC transporter signature motif; other site 288681007373 Walker B; other site 288681007374 D-loop; other site 288681007375 H-loop/switch region; other site 288681007376 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 288681007377 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 288681007378 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 288681007379 Clp protease; Region: CLP_protease; pfam00574 288681007380 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288681007381 oligomer interface [polypeptide binding]; other site 288681007382 active site residues [active] 288681007383 RNA polymerase factor sigma-70; Validated; Region: PRK06704 288681007384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681007385 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681007386 DNA binding residues [nucleotide binding] 288681007387 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 288681007388 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 288681007389 catalytic loop [active] 288681007390 iron binding site [ion binding]; other site 288681007391 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 288681007392 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681007393 active site 288681007394 dimer interface [polypeptide binding]; other site 288681007395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007396 Coenzyme A binding pocket [chemical binding]; other site 288681007397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 288681007398 Chitin binding domain; Region: Chitin_bind_3; pfam03067 288681007399 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681007400 Interdomain contacts; other site 288681007401 Cytokine receptor motif; other site 288681007402 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681007403 Interdomain contacts; other site 288681007404 Cytokine receptor motif; other site 288681007405 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 288681007406 topology modulation protein; Reviewed; Region: PRK08118 288681007407 AAA domain; Region: AAA_17; pfam13207 288681007408 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 288681007409 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 288681007410 substrate binding site [chemical binding]; other site 288681007411 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 288681007412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007413 S-adenosylmethionine binding site [chemical binding]; other site 288681007414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 288681007415 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007416 Coenzyme A binding pocket [chemical binding]; other site 288681007417 S-layer homology domain; Region: SLH; pfam00395 288681007418 S-layer homology domain; Region: SLH; pfam00395 288681007419 S-layer homology domain; Region: SLH; pfam00395 288681007420 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 288681007421 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681007422 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 288681007423 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 288681007424 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 288681007425 active site 288681007426 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 288681007427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007428 Coenzyme A binding pocket [chemical binding]; other site 288681007429 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 288681007430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007431 Coenzyme A binding pocket [chemical binding]; other site 288681007432 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681007433 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681007434 Protein of unknown function (DUF952); Region: DUF952; pfam06108 288681007435 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 288681007436 Part of AAA domain; Region: AAA_19; pfam13245 288681007437 Family description; Region: UvrD_C_2; pfam13538 288681007438 CAAX protease self-immunity; Region: Abi; pfam02517 288681007439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007440 S-adenosylmethionine binding site [chemical binding]; other site 288681007441 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 288681007442 putative active site pocket [active] 288681007443 dimerization interface [polypeptide binding]; other site 288681007444 putative catalytic residue [active] 288681007445 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 288681007446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681007447 ATP binding site [chemical binding]; other site 288681007448 putative Mg++ binding site [ion binding]; other site 288681007449 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681007450 nucleotide binding region [chemical binding]; other site 288681007451 ATP-binding site [chemical binding]; other site 288681007452 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 288681007453 HRDC domain; Region: HRDC; pfam00570 288681007454 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 288681007455 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 288681007456 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 288681007457 active site 288681007458 Zn binding site [ion binding]; other site 288681007459 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 288681007460 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 288681007461 DHHA2 domain; Region: DHHA2; pfam02833 288681007462 Chitin binding domain; Region: Chitin_bind_3; pfam03067 288681007463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681007464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007465 Coenzyme A binding pocket [chemical binding]; other site 288681007466 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 288681007467 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681007468 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 288681007469 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 288681007470 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 288681007471 NAD(P) binding site [chemical binding]; other site 288681007472 catalytic residues [active] 288681007473 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 288681007474 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 288681007475 inhibitor site; inhibition site 288681007476 active site 288681007477 dimer interface [polypeptide binding]; other site 288681007478 catalytic residue [active] 288681007479 Proline racemase; Region: Pro_racemase; pfam05544 288681007480 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681007481 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681007482 Proline racemase; Region: Pro_racemase; pfam05544 288681007483 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681007484 hydroxyglutarate oxidase; Provisional; Region: PRK11728 288681007485 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 288681007486 PAS domain; Region: PAS_10; pfam13596 288681007487 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 288681007488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007489 Walker A motif; other site 288681007490 ATP binding site [chemical binding]; other site 288681007491 Walker B motif; other site 288681007492 arginine finger; other site 288681007493 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 288681007494 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 288681007495 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 288681007496 catalytic loop [active] 288681007497 iron binding site [ion binding]; other site 288681007498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 288681007499 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681007500 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 288681007501 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681007502 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 288681007503 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681007504 active site 288681007505 metal binding site [ion binding]; metal-binding site 288681007506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007507 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681007508 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 288681007509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681007510 Zn2+ binding site [ion binding]; other site 288681007511 Mg2+ binding site [ion binding]; other site 288681007512 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681007513 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288681007514 DinB superfamily; Region: DinB_2; pfam12867 288681007515 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 288681007516 DltD N-terminal region; Region: DltD_N; pfam04915 288681007517 DltD central region; Region: DltD_M; pfam04918 288681007518 DltD C-terminal region; Region: DltD_C; pfam04914 288681007519 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007521 Coenzyme A binding pocket [chemical binding]; other site 288681007522 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681007523 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681007524 peptide binding site [polypeptide binding]; other site 288681007525 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288681007526 NlpC/P60 family; Region: NLPC_P60; pfam00877 288681007527 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 288681007528 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 288681007529 active site 288681007530 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 288681007531 Septum formation initiator; Region: DivIC; pfam04977 288681007532 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 288681007533 DJ-1 family protein; Region: not_thiJ; TIGR01383 288681007534 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 288681007535 conserved cys residue [active] 288681007536 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681007537 active site 288681007538 catalytic motif [active] 288681007539 Zn binding site [ion binding]; other site 288681007540 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681007541 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007542 S-adenosylmethionine binding site [chemical binding]; other site 288681007543 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 288681007544 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 288681007545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681007546 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681007547 dimerization interface [polypeptide binding]; other site 288681007548 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681007549 dimer interface [polypeptide binding]; other site 288681007550 phosphorylation site [posttranslational modification] 288681007551 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681007552 ATP binding site [chemical binding]; other site 288681007553 Mg2+ binding site [ion binding]; other site 288681007554 G-X-G motif; other site 288681007555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681007556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681007557 active site 288681007558 phosphorylation site [posttranslational modification] 288681007559 intermolecular recognition site; other site 288681007560 dimerization interface [polypeptide binding]; other site 288681007561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681007562 DNA binding site [nucleotide binding] 288681007563 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681007564 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681007565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007566 motif II; other site 288681007567 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 288681007568 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 288681007569 Phosphotransferase enzyme family; Region: APH; pfam01636 288681007570 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681007571 substrate binding site [chemical binding]; other site 288681007572 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681007573 Phosphotransferase enzyme family; Region: APH; pfam01636 288681007574 active site 288681007575 ATP binding site [chemical binding]; other site 288681007576 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 288681007577 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 288681007578 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681007579 Zn binding site [ion binding]; other site 288681007580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681007581 non-specific DNA binding site [nucleotide binding]; other site 288681007582 salt bridge; other site 288681007583 sequence-specific DNA binding site [nucleotide binding]; other site 288681007584 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681007585 EDD domain protein, DegV family; Region: DegV; TIGR00762 288681007586 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 288681007587 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 288681007588 Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into: topo type IA; Region: Topoisomer_IB_N; cl02774 288681007589 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 288681007590 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 288681007591 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007592 Coenzyme A binding pocket [chemical binding]; other site 288681007593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681007594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007595 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681007596 putative substrate translocation pore; other site 288681007597 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 288681007598 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 288681007599 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 288681007600 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 288681007601 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 288681007602 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 288681007603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681007605 putative substrate translocation pore; other site 288681007606 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 288681007607 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 288681007608 active site 288681007609 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 288681007610 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681007611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681007612 S-adenosylmethionine binding site [chemical binding]; other site 288681007613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007614 putative substrate translocation pore; other site 288681007615 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681007616 aspartate aminotransferase; Provisional; Region: PRK07681 288681007617 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007618 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007619 homodimer interface [polypeptide binding]; other site 288681007620 catalytic residue [active] 288681007621 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 288681007622 pantothenate kinase; Provisional; Region: PRK13317 288681007623 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 288681007624 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 288681007625 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 288681007626 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 288681007627 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681007628 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681007629 Walker A/P-loop; other site 288681007630 ATP binding site [chemical binding]; other site 288681007631 Q-loop/lid; other site 288681007632 ABC transporter signature motif; other site 288681007633 Walker B; other site 288681007634 D-loop; other site 288681007635 H-loop/switch region; other site 288681007636 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681007637 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681007638 DNA-binding site [nucleotide binding]; DNA binding site 288681007639 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681007640 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681007641 HNH endonuclease; Region: HNH_5; pfam14279 288681007642 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 288681007643 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 288681007644 active site 288681007645 dimer interface [polypeptide binding]; other site 288681007646 non-prolyl cis peptide bond; other site 288681007647 insertion regions; other site 288681007648 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288681007649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681007650 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 288681007651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681007652 substrate binding pocket [chemical binding]; other site 288681007653 membrane-bound complex binding site; other site 288681007654 hinge residues; other site 288681007655 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681007656 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 288681007657 Walker A/P-loop; other site 288681007658 ATP binding site [chemical binding]; other site 288681007659 Q-loop/lid; other site 288681007660 ABC transporter signature motif; other site 288681007661 Walker B; other site 288681007662 D-loop; other site 288681007663 H-loop/switch region; other site 288681007664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681007665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681007666 Protein of unknown function (DUF402); Region: DUF402; pfam04167 288681007667 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 288681007668 nudix motif; other site 288681007669 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681007670 binding surface 288681007671 TPR motif; other site 288681007672 hypothetical protein; Provisional; Region: PRK09620 288681007673 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 288681007674 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 288681007675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 288681007676 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681007677 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 288681007678 DinB superfamily; Region: DinB_2; pfam12867 288681007679 Protein of unknown function (DUF664); Region: DUF664; pfam04978 288681007680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 288681007681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007682 Coenzyme A binding pocket [chemical binding]; other site 288681007683 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007684 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681007685 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681007686 active site 288681007687 NTP binding site [chemical binding]; other site 288681007688 metal binding triad [ion binding]; metal-binding site 288681007689 antibiotic binding site [chemical binding]; other site 288681007690 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288681007691 A new structural DNA glycosylase; Region: AlkD_like; cd06561 288681007692 active site 288681007693 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 288681007694 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681007695 NodB motif; other site 288681007696 active site 288681007697 catalytic site [active] 288681007698 Zn binding site [ion binding]; other site 288681007699 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 288681007700 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 288681007701 active site 288681007702 P-loop; other site 288681007703 phosphorylation site [posttranslational modification] 288681007704 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 288681007705 HTH domain; Region: HTH_11; pfam08279 288681007706 Mga helix-turn-helix domain; Region: Mga; pfam05043 288681007707 PRD domain; Region: PRD; pfam00874 288681007708 PRD domain; Region: PRD; pfam00874 288681007709 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 288681007710 active site 288681007711 P-loop; other site 288681007712 phosphorylation site [posttranslational modification] 288681007713 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288681007714 active site 288681007715 phosphorylation site [posttranslational modification] 288681007716 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 288681007717 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681007718 Sulfatase; Region: Sulfatase; pfam00884 288681007719 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 288681007720 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681007721 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681007722 ABC transporter; Region: ABC_tran_2; pfam12848 288681007723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681007724 hypothetical protein; Provisional; Region: PRK06761 288681007725 MMPL family; Region: MMPL; pfam03176 288681007726 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 288681007727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681007728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681007729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007730 Coenzyme A binding pocket [chemical binding]; other site 288681007731 Sterol carrier protein domain; Region: SCP2_2; pfam13530 288681007732 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 288681007733 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 288681007734 hinge; other site 288681007735 active site 288681007736 prephenate dehydrogenase; Validated; Region: PRK06545 288681007737 prephenate dehydrogenase; Validated; Region: PRK08507 288681007738 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 288681007739 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 288681007740 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681007741 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007742 homodimer interface [polypeptide binding]; other site 288681007743 catalytic residue [active] 288681007744 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 288681007745 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 288681007746 Tetramer interface [polypeptide binding]; other site 288681007747 active site 288681007748 FMN-binding site [chemical binding]; other site 288681007749 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 288681007750 Chorismate mutase type II; Region: CM_2; cl00693 288681007751 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 288681007752 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 288681007753 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 288681007754 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 288681007755 Isochorismatase family; Region: Isochorismatase; pfam00857 288681007756 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681007757 catalytic triad [active] 288681007758 conserved cis-peptide bond; other site 288681007759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007761 Coenzyme A binding pocket [chemical binding]; other site 288681007762 YfzA-like protein; Region: YfzA; pfam14118 288681007763 hypothetical protein; Provisional; Region: PRK06762 288681007764 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG1102 288681007765 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681007766 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681007767 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 288681007768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007770 Coenzyme A binding pocket [chemical binding]; other site 288681007771 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 288681007772 enoyl-CoA hydratase; Provisional; Region: PRK06688 288681007773 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681007774 substrate binding site [chemical binding]; other site 288681007775 oxyanion hole (OAH) forming residues; other site 288681007776 trimer interface [polypeptide binding]; other site 288681007777 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 288681007778 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681007779 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 288681007780 putative AMP binding site [chemical binding]; other site 288681007781 putative active site [active] 288681007782 acyl-activating enzyme (AAE) consensus motif; other site 288681007783 putative CoA binding site [chemical binding]; other site 288681007784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007785 Walker B motif; other site 288681007786 arginine finger; other site 288681007787 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 288681007788 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681007789 putative active site [active] 288681007790 heme pocket [chemical binding]; other site 288681007791 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 288681007792 malate:quinone oxidoreductase; Validated; Region: PRK05257 288681007793 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 288681007794 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 288681007795 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 288681007796 ligand binding site [chemical binding]; other site 288681007797 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288681007798 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288681007799 TM-ABC transporter signature motif; other site 288681007800 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288681007801 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 288681007802 TM-ABC transporter signature motif; other site 288681007803 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 288681007804 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 288681007805 Walker A/P-loop; other site 288681007806 ATP binding site [chemical binding]; other site 288681007807 Q-loop/lid; other site 288681007808 ABC transporter signature motif; other site 288681007809 Walker B; other site 288681007810 D-loop; other site 288681007811 H-loop/switch region; other site 288681007812 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 288681007813 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288681007814 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288681007815 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 288681007816 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 288681007817 putative N- and C-terminal domain interface [polypeptide binding]; other site 288681007818 putative active site [active] 288681007819 putative MgATP binding site [chemical binding]; other site 288681007820 catalytic site [active] 288681007821 metal binding site [ion binding]; metal-binding site 288681007822 putative carbohydrate binding site [chemical binding]; other site 288681007823 Cupin domain; Region: Cupin_2; pfam07883 288681007824 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 288681007825 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 288681007826 putative active site; other site 288681007827 catalytic residue [active] 288681007828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007829 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681007830 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 288681007831 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681007832 active site 288681007833 NTP binding site [chemical binding]; other site 288681007834 metal binding triad [ion binding]; metal-binding site 288681007835 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 288681007836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007837 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681007838 putative substrate translocation pore; other site 288681007839 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681007840 putative DNA binding site [nucleotide binding]; other site 288681007841 putative Zn2+ binding site [ion binding]; other site 288681007842 DinB superfamily; Region: DinB_2; pfam12867 288681007843 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681007844 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681007845 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681007846 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 288681007847 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 288681007848 putative catalytic cysteine [active] 288681007849 gamma-glutamyl kinase; Provisional; Region: PRK05429 288681007850 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 288681007851 nucleotide binding site [chemical binding]; other site 288681007852 homotetrameric interface [polypeptide binding]; other site 288681007853 putative phosphate binding site [ion binding]; other site 288681007854 putative allosteric binding site; other site 288681007855 PUA domain; Region: PUA; pfam01472 288681007856 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 288681007857 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 288681007858 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 288681007859 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 288681007860 putative metal binding site [ion binding]; other site 288681007861 putative dimer interface [polypeptide binding]; other site 288681007862 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 288681007863 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288681007864 Bacterial transcriptional regulator; Region: IclR; pfam01614 288681007865 S-methylmethionine transporter; Provisional; Region: PRK11387 288681007866 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 288681007867 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 288681007868 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 288681007869 putative di-iron ligands [ion binding]; other site 288681007870 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 288681007871 dimer interface [polypeptide binding]; other site 288681007872 Alkaline phosphatase homologues; Region: alkPPc; smart00098 288681007873 active site 288681007874 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 288681007875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681007876 salt bridge; other site 288681007877 non-specific DNA binding site [nucleotide binding]; other site 288681007878 sequence-specific DNA binding site [nucleotide binding]; other site 288681007879 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 288681007880 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 288681007881 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 288681007882 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681007883 LytTr DNA-binding domain; Region: LytTR; pfam04397 288681007884 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 288681007885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681007886 motif II; other site 288681007887 uridine kinase; Provisional; Region: PRK07667 288681007888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681007889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681007890 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681007891 Coenzyme A binding pocket [chemical binding]; other site 288681007892 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681007893 active site 288681007894 metal binding site [ion binding]; metal-binding site 288681007895 CAAX protease self-immunity; Region: Abi; pfam02517 288681007896 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 288681007897 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681007898 Transcriptional regulator PadR-like family; Region: PadR; cl17335 288681007899 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681007900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007901 Walker A motif; other site 288681007902 ATP binding site [chemical binding]; other site 288681007903 Walker B motif; other site 288681007904 arginine finger; other site 288681007905 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681007906 Protein of unknown function DUF58; Region: DUF58; pfam01882 288681007907 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 288681007908 proline/glycine betaine transporter; Provisional; Region: PRK10642 288681007909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681007910 putative substrate translocation pore; other site 288681007911 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681007912 active site 288681007913 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681007914 active site 288681007915 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681007916 Ligand binding site; other site 288681007917 Putative Catalytic site; other site 288681007918 DXD motif; other site 288681007919 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681007920 active site 288681007921 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681007922 Ligand binding site; other site 288681007923 Putative Catalytic site; other site 288681007924 DXD motif; other site 288681007925 acetylornithine aminotransferase; Provisional; Region: PRK02627 288681007926 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681007927 inhibitor-cofactor binding pocket; inhibition site 288681007928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681007929 catalytic residue [active] 288681007930 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 288681007931 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288681007932 tetramer interface [polypeptide binding]; other site 288681007933 heme binding pocket [chemical binding]; other site 288681007934 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288681007935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681007936 dimer interface [polypeptide binding]; other site 288681007937 conserved gate region; other site 288681007938 putative PBP binding loops; other site 288681007939 ABC-ATPase subunit interface; other site 288681007940 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681007941 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 288681007942 Walker A/P-loop; other site 288681007943 ATP binding site [chemical binding]; other site 288681007944 Q-loop/lid; other site 288681007945 ABC transporter signature motif; other site 288681007946 Walker B; other site 288681007947 D-loop; other site 288681007948 H-loop/switch region; other site 288681007949 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 288681007950 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681007951 membrane-bound complex binding site; other site 288681007952 hinge residues; other site 288681007953 Arylsulfotransferase (ASST); Region: Arylsulfotran_2; pfam14269 288681007954 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681007955 MarR family; Region: MarR_2; pfam12802 288681007956 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 288681007957 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288681007958 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 288681007959 active site 288681007960 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 288681007961 LysE type translocator; Region: LysE; pfam01810 288681007962 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681007963 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681007964 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 288681007965 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 288681007966 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681007967 Protein of unknown function DUF58; Region: DUF58; pfam01882 288681007968 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681007969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681007970 Walker A motif; other site 288681007971 ATP binding site [chemical binding]; other site 288681007972 Walker B motif; other site 288681007973 arginine finger; other site 288681007974 Uncharacterized conserved protein [Function unknown]; Region: COG1359 288681007975 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 288681007976 dimer interface [polypeptide binding]; other site 288681007977 FMN binding site [chemical binding]; other site 288681007978 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681007979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681007980 putative DNA binding site [nucleotide binding]; other site 288681007981 putative Zn2+ binding site [ion binding]; other site 288681007982 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 288681007983 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 288681007984 G1 box; other site 288681007985 putative GEF interaction site [polypeptide binding]; other site 288681007986 GTP/Mg2+ binding site [chemical binding]; other site 288681007987 Switch I region; other site 288681007988 G2 box; other site 288681007989 G3 box; other site 288681007990 Switch II region; other site 288681007991 G4 box; other site 288681007992 G5 box; other site 288681007993 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 288681007994 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 288681007995 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 288681007996 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 288681007997 nudix motif; other site 288681007998 YfzA-like protein; Region: YfzA; pfam14118 288681007999 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681008000 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681008001 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681008002 Walker A/P-loop; other site 288681008003 ATP binding site [chemical binding]; other site 288681008004 Q-loop/lid; other site 288681008005 ABC transporter signature motif; other site 288681008006 Walker B; other site 288681008007 D-loop; other site 288681008008 H-loop/switch region; other site 288681008009 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681008010 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681008011 DNA-binding site [nucleotide binding]; DNA binding site 288681008012 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 288681008013 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681008014 putative NAD(P) binding site [chemical binding]; other site 288681008015 active site 288681008016 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008017 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681008018 Walker A/P-loop; other site 288681008019 ATP binding site [chemical binding]; other site 288681008020 Q-loop/lid; other site 288681008021 ABC transporter signature motif; other site 288681008022 Walker B; other site 288681008023 D-loop; other site 288681008024 H-loop/switch region; other site 288681008025 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008026 FtsX-like permease family; Region: FtsX; pfam02687 288681008027 FtsX-like permease family; Region: FtsX; pfam02687 288681008028 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008029 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008030 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681008031 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681008032 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 288681008033 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681008034 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008035 Coenzyme A binding pocket [chemical binding]; other site 288681008036 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 288681008037 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 288681008038 nudix motif; other site 288681008039 EamA-like transporter family; Region: EamA; pfam00892 288681008040 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681008041 EamA-like transporter family; Region: EamA; pfam00892 288681008042 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681008043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681008044 DNA-binding site [nucleotide binding]; DNA binding site 288681008045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681008046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681008047 homodimer interface [polypeptide binding]; other site 288681008048 catalytic residue [active] 288681008049 hypothetical protein; Validated; Region: PRK00124 288681008050 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 288681008051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681008052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681008053 phosphorylation site [posttranslational modification] 288681008054 dimer interface [polypeptide binding]; other site 288681008055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008056 ATP binding site [chemical binding]; other site 288681008057 Mg2+ binding site [ion binding]; other site 288681008058 G-X-G motif; other site 288681008059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681008060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008061 active site 288681008062 phosphorylation site [posttranslational modification] 288681008063 intermolecular recognition site; other site 288681008064 dimerization interface [polypeptide binding]; other site 288681008065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681008066 DNA binding site [nucleotide binding] 288681008067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681008068 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 288681008069 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 288681008070 uridine kinase; Validated; Region: PRK06696 288681008071 active site 288681008072 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 288681008073 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681008074 active site 288681008075 metal binding site [ion binding]; metal-binding site 288681008076 Phosphotransferase enzyme family; Region: APH; pfam01636 288681008077 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681008078 active site 288681008079 substrate binding site [chemical binding]; other site 288681008080 ATP binding site [chemical binding]; other site 288681008081 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 288681008082 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681008083 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681008084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008085 Coenzyme A binding pocket [chemical binding]; other site 288681008086 lysine transporter; Provisional; Region: PRK10836 288681008087 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 288681008088 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681008089 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681008090 DNA binding residues [nucleotide binding] 288681008091 dimer interface [polypeptide binding]; other site 288681008092 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681008093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008094 S-adenosylmethionine binding site [chemical binding]; other site 288681008095 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681008096 putative active site [active] 288681008097 nucleotide binding site [chemical binding]; other site 288681008098 nudix motif; other site 288681008099 putative metal binding site [ion binding]; other site 288681008100 Cephalosporin hydroxylase; Region: CmcI; pfam04989 288681008101 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681008102 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681008103 Catalytic site [active] 288681008104 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681008105 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681008106 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681008107 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681008108 NAD-dependent deacetylase; Provisional; Region: PRK00481 288681008109 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 288681008110 NAD+ binding site [chemical binding]; other site 288681008111 substrate binding site [chemical binding]; other site 288681008112 Zn binding site [ion binding]; other site 288681008113 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 288681008114 putative substrate binding pocket [chemical binding]; other site 288681008115 AC domain interface; other site 288681008116 catalytic triad [active] 288681008117 AB domain interface; other site 288681008118 interchain disulfide; other site 288681008119 Predicted membrane protein [Function unknown]; Region: COG3817 288681008120 Protein of unknown function (DUF979); Region: DUF979; pfam06166 288681008121 Protein of unknown function (DUF969); Region: DUF969; pfam06149 288681008122 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 288681008123 putative active site [active] 288681008124 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 288681008125 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 288681008126 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 288681008127 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288681008128 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 288681008129 Bacterial transcriptional regulator; Region: IclR; pfam01614 288681008130 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681008131 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681008132 Catalytic site [active] 288681008133 CutC family; Region: CutC; cl01218 288681008134 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 288681008135 stage II sporulation protein P; Region: spore_II_P; TIGR02867 288681008136 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008137 dimerization interface [polypeptide binding]; other site 288681008138 putative DNA binding site [nucleotide binding]; other site 288681008139 putative Zn2+ binding site [ion binding]; other site 288681008140 DinB superfamily; Region: DinB_2; pfam12867 288681008141 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681008142 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288681008143 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 288681008144 Uncharacterized conserved protein [Function unknown]; Region: COG1434 288681008145 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681008146 putative active site [active] 288681008147 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681008148 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681008149 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 288681008150 Nucleoside recognition; Region: Gate; pfam07670 288681008151 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008152 Coenzyme A binding pocket [chemical binding]; other site 288681008153 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681008154 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681008155 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681008156 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681008157 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 288681008158 phosphoenolpyruvate synthase; Validated; Region: PRK06241 288681008159 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 288681008160 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 288681008161 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 288681008162 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681008163 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 288681008164 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 288681008165 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 288681008166 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 288681008167 LysE type translocator; Region: LysE; pfam01810 288681008168 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 288681008169 Spore germination protein; Region: Spore_permease; cl17796 288681008170 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681008171 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 288681008172 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 288681008173 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681008174 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 288681008175 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681008176 NAD binding site [chemical binding]; other site 288681008177 catalytic Zn binding site [ion binding]; other site 288681008178 structural Zn binding site [ion binding]; other site 288681008179 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 288681008180 dimanganese center [ion binding]; other site 288681008181 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681008182 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681008183 DNA binding residues [nucleotide binding] 288681008184 dimer interface [polypeptide binding]; other site 288681008185 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681008186 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681008187 FtsX-like permease family; Region: FtsX; pfam02687 288681008188 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008189 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681008190 Walker A/P-loop; other site 288681008191 ATP binding site [chemical binding]; other site 288681008192 Q-loop/lid; other site 288681008193 ABC transporter signature motif; other site 288681008194 Walker B; other site 288681008195 D-loop; other site 288681008196 H-loop/switch region; other site 288681008197 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 288681008198 aspartate ammonia-lyase; Provisional; Region: PRK14515 288681008199 Aspartase; Region: Aspartase; cd01357 288681008200 active sites [active] 288681008201 tetramer interface [polypeptide binding]; other site 288681008202 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 288681008203 active site 288681008204 homodimer interface [polypeptide binding]; other site 288681008205 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681008206 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008207 non-specific DNA binding site [nucleotide binding]; other site 288681008208 salt bridge; other site 288681008209 sequence-specific DNA binding site [nucleotide binding]; other site 288681008210 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288681008211 GIY-YIG motif/motif A; other site 288681008212 active site 288681008213 catalytic site [active] 288681008214 putative DNA binding site [nucleotide binding]; other site 288681008215 metal binding site [ion binding]; metal-binding site 288681008216 amino acid transporter; Region: 2A0306; TIGR00909 288681008217 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 288681008218 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 288681008219 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 288681008220 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681008221 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681008222 Spore germination protein; Region: Spore_permease; pfam03845 288681008223 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681008224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008225 Response regulator receiver domain; Region: Response_reg; pfam00072 288681008226 active site 288681008227 phosphorylation site [posttranslational modification] 288681008228 intermolecular recognition site; other site 288681008229 dimerization interface [polypeptide binding]; other site 288681008230 YcbB domain; Region: YcbB; pfam08664 288681008231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681008232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008233 ATP binding site [chemical binding]; other site 288681008234 Mg2+ binding site [ion binding]; other site 288681008235 G-X-G motif; other site 288681008236 glutaminase; Reviewed; Region: PRK12357 288681008237 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 288681008238 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681008239 amino acid carrier protein; Region: agcS; TIGR00835 288681008240 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 288681008241 transmembrane helices; other site 288681008242 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008243 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008244 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 288681008245 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 288681008246 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 288681008247 [2Fe-2S] cluster binding site [ion binding]; other site 288681008248 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 288681008249 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 288681008250 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 288681008251 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681008252 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 288681008253 putative active site [active] 288681008254 putative metal binding site [ion binding]; other site 288681008255 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681008256 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 288681008257 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 288681008258 tetramer interface [polypeptide binding]; other site 288681008259 heme binding pocket [chemical binding]; other site 288681008260 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 288681008261 Cl binding site [ion binding]; other site 288681008262 oligomer interface [polypeptide binding]; other site 288681008263 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 288681008264 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 288681008265 Mg binding site [ion binding]; other site 288681008266 nucleotide binding site [chemical binding]; other site 288681008267 putative protofilament interface [polypeptide binding]; other site 288681008268 Heat induced stress protein YflT; Region: YflT; pfam11181 288681008269 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 288681008270 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 288681008271 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 288681008272 Carbonic anhydrase; Region: Pro_CA; pfam00484 288681008273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 288681008274 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 288681008275 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 288681008276 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 288681008277 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 288681008278 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 288681008279 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 288681008280 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 288681008281 homodimer interface [polypeptide binding]; other site 288681008282 putative substrate binding pocket [chemical binding]; other site 288681008283 diiron center [ion binding]; other site 288681008284 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681008285 putative active site [active] 288681008286 catalytic site [active] 288681008287 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681008288 PLD-like domain; Region: PLDc_2; pfam13091 288681008289 putative active site [active] 288681008290 catalytic site [active] 288681008291 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681008292 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 288681008293 UbiA prenyltransferase family; Region: UbiA; pfam01040 288681008294 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681008295 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 288681008296 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 288681008297 B12 binding site [chemical binding]; other site 288681008298 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 288681008299 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 288681008300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681008302 Walker A/P-loop; other site 288681008303 ATP binding site [chemical binding]; other site 288681008304 Q-loop/lid; other site 288681008305 ABC transporter signature motif; other site 288681008306 Walker B; other site 288681008307 D-loop; other site 288681008308 H-loop/switch region; other site 288681008309 FtsX-like permease family; Region: FtsX; pfam02687 288681008310 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681008311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008312 ATP binding site [chemical binding]; other site 288681008313 Mg2+ binding site [ion binding]; other site 288681008314 G-X-G motif; other site 288681008315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681008316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008317 active site 288681008318 dimerization interface [polypeptide binding]; other site 288681008319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681008320 DNA binding residues [nucleotide binding] 288681008321 dimerization interface [polypeptide binding]; other site 288681008322 Phosphotransferase enzyme family; Region: APH; pfam01636 288681008323 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681008324 active site 288681008325 ATP binding site [chemical binding]; other site 288681008326 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 288681008327 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 288681008328 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288681008329 active site 288681008330 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 288681008331 arsenical-resistance protein; Region: acr3; TIGR00832 288681008332 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008333 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 288681008334 putative metal binding site [ion binding]; other site 288681008335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008336 dimerization interface [polypeptide binding]; other site 288681008337 putative DNA binding site [nucleotide binding]; other site 288681008338 putative Zn2+ binding site [ion binding]; other site 288681008339 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 288681008340 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 288681008341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681008342 binding surface 288681008343 TPR motif; other site 288681008344 TPR repeat; Region: TPR_11; pfam13414 288681008345 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 288681008346 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 288681008347 nucleotide binding site [chemical binding]; other site 288681008348 putative NEF/HSP70 interaction site [polypeptide binding]; other site 288681008349 SBD interface [polypeptide binding]; other site 288681008350 short chain dehydrogenase; Provisional; Region: PRK12746 288681008351 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 288681008352 NADP binding site [chemical binding]; other site 288681008353 homodimer interface [polypeptide binding]; other site 288681008354 active site 288681008355 substrate binding site [chemical binding]; other site 288681008356 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 288681008357 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008358 putative DNA binding site [nucleotide binding]; other site 288681008359 putative Zn2+ binding site [ion binding]; other site 288681008360 AsnC family; Region: AsnC_trans_reg; pfam01037 288681008361 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 288681008362 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681008363 metal binding site [ion binding]; metal-binding site 288681008364 AAA domain; Region: AAA_11; pfam13086 288681008365 Part of AAA domain; Region: AAA_19; pfam13245 288681008366 Erp protein C-terminus; Region: Erp_C; pfam06780 288681008367 AAA domain; Region: AAA_30; pfam13604 288681008368 AAA domain; Region: AAA_12; pfam13087 288681008369 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 288681008370 putative active site [active] 288681008371 catalytic site [active] 288681008372 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008373 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681008374 active site 288681008375 metal binding site [ion binding]; metal-binding site 288681008376 HEAT repeats; Region: HEAT_2; pfam13646 288681008377 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 288681008378 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 288681008379 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 288681008380 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681008381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681008382 putative transporter; Provisional; Region: PRK11021 288681008383 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008384 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008385 hypothetical protein; Provisional; Region: PRK06770 288681008386 putative monooxygenase; Provisional; Region: PRK11118 288681008387 DoxX-like family; Region: DoxX_2; pfam13564 288681008388 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681008389 MarR family; Region: MarR_2; pfam12802 288681008390 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 288681008391 Cytochrome P450; Region: p450; pfam00067 288681008392 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 288681008393 Flavodoxin; Region: Flavodoxin_1; pfam00258 288681008394 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 288681008395 FAD binding pocket [chemical binding]; other site 288681008396 FAD binding motif [chemical binding]; other site 288681008397 catalytic residues [active] 288681008398 NAD binding pocket [chemical binding]; other site 288681008399 phosphate binding motif [ion binding]; other site 288681008400 beta-alpha-beta structure motif; other site 288681008401 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681008402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008403 putative substrate translocation pore; other site 288681008404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008405 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 288681008406 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 288681008407 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 288681008408 D-cysteine desulfhydrase; Validated; Region: PRK03910 288681008409 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 288681008410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681008411 catalytic residue [active] 288681008412 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681008413 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 288681008414 active site 288681008415 metal binding site [ion binding]; metal-binding site 288681008416 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 288681008417 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008418 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008420 salt bridge; other site 288681008421 non-specific DNA binding site [nucleotide binding]; other site 288681008422 sequence-specific DNA binding site [nucleotide binding]; other site 288681008423 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 288681008424 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 288681008425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 288681008426 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681008427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008428 NAD(P) binding site [chemical binding]; other site 288681008429 active site 288681008430 hypothetical protein; Provisional; Region: PRK06849 288681008431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008432 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 288681008433 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 288681008434 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681008435 dimer interface [polypeptide binding]; other site 288681008436 active site 288681008437 CoA binding pocket [chemical binding]; other site 288681008438 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 288681008439 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 288681008440 AAA domain; Region: AAA_33; pfam13671 288681008441 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 288681008442 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008443 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681008444 Walker A/P-loop; other site 288681008445 ATP binding site [chemical binding]; other site 288681008446 Q-loop/lid; other site 288681008447 ABC transporter signature motif; other site 288681008448 Walker B; other site 288681008449 D-loop; other site 288681008450 H-loop/switch region; other site 288681008451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681008453 FtsX-like permease family; Region: FtsX; pfam02687 288681008454 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008455 dimerization interface [polypeptide binding]; other site 288681008456 putative DNA binding site [nucleotide binding]; other site 288681008457 Predicted transcriptional regulator [Transcription]; Region: COG2345 288681008458 putative Zn2+ binding site [ion binding]; other site 288681008459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008460 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681008461 putative substrate translocation pore; other site 288681008462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681008463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681008464 dimerization interface [polypeptide binding]; other site 288681008465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681008466 dimer interface [polypeptide binding]; other site 288681008467 phosphorylation site [posttranslational modification] 288681008468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008469 ATP binding site [chemical binding]; other site 288681008470 Mg2+ binding site [ion binding]; other site 288681008471 G-X-G motif; other site 288681008472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681008473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008474 active site 288681008475 phosphorylation site [posttranslational modification] 288681008476 intermolecular recognition site; other site 288681008477 dimerization interface [polypeptide binding]; other site 288681008478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681008479 DNA binding site [nucleotide binding] 288681008480 Predicted membrane protein [Function unknown]; Region: COG2364 288681008481 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681008482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 288681008483 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 288681008484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008485 Coenzyme A binding pocket [chemical binding]; other site 288681008486 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 288681008487 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681008488 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681008489 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681008490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008491 D-galactonate transporter; Region: 2A0114; TIGR00893 288681008492 putative substrate translocation pore; other site 288681008493 Uncharacterized conserved protein [Function unknown]; Region: COG1556 288681008494 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 288681008495 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 288681008496 4Fe-4S binding domain; Region: Fer4; pfam00037 288681008497 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 288681008498 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 288681008499 Cysteine-rich domain; Region: CCG; pfam02754 288681008500 Cysteine-rich domain; Region: CCG; pfam02754 288681008501 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681008502 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681008503 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681008504 dimerization interface [polypeptide binding]; other site 288681008505 2TM domain; Region: 2TM; pfam13239 288681008506 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681008507 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681008508 putative dimer interface [polypeptide binding]; other site 288681008509 catalytic triad [active] 288681008510 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 288681008511 Uncharacterized conserved protein [Function unknown]; Region: COG4198 288681008512 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 288681008513 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 288681008514 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 288681008515 putative ligand binding site [chemical binding]; other site 288681008516 putative NAD binding site [chemical binding]; other site 288681008517 putative catalytic site [active] 288681008518 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 288681008519 L-serine binding site [chemical binding]; other site 288681008520 ACT domain interface; other site 288681008521 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 288681008522 homodimer interface [polypeptide binding]; other site 288681008523 substrate-cofactor binding pocket; other site 288681008524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681008525 catalytic residue [active] 288681008526 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 288681008527 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 288681008528 RNA polymerase sigma factor SigM; Provisional; Region: PRK09644 288681008529 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681008530 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 288681008531 DNA binding residues [nucleotide binding] 288681008532 Domain of unknown function (DUF378); Region: DUF378; cl00943 288681008533 Cupin domain; Region: Cupin_2; cl17218 288681008534 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 288681008535 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681008536 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 288681008537 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 288681008538 Proteins of 100 residues with WXG; Region: WXG100; cl02005 288681008539 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 288681008540 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 288681008541 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 288681008542 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 288681008543 active site 288681008544 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 288681008545 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681008546 amidase catalytic site [active] 288681008547 Zn binding residues [ion binding]; other site 288681008548 substrate binding site [chemical binding]; other site 288681008549 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681008550 S-layer homology domain; Region: SLH; pfam00395 288681008551 S-layer homology domain; Region: SLH; pfam00395 288681008552 S-layer homology domain; Region: SLH; pfam00395 288681008553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681008554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681008555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008556 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008557 putative substrate translocation pore; other site 288681008558 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288681008559 A new structural DNA glycosylase; Region: AlkD_like; cd06561 288681008560 active site 288681008561 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 288681008562 S-layer homology domain; Region: SLH; pfam00395 288681008563 S-layer homology domain; Region: SLH; pfam00395 288681008564 S-layer homology domain; Region: SLH; pfam00395 288681008565 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 288681008566 putative metal binding site [ion binding]; other site 288681008567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008568 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 288681008569 NETI protein; Region: NETI; pfam14044 288681008570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008572 putative substrate translocation pore; other site 288681008573 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681008574 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681008575 TAP-like protein; Region: Abhydrolase_4; pfam08386 288681008576 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681008577 MarR family; Region: MarR_2; pfam12802 288681008578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008579 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008580 putative substrate translocation pore; other site 288681008581 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008582 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008583 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 288681008584 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 288681008585 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 288681008586 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288681008587 SWIM zinc finger; Region: SWIM; pfam04434 288681008588 YwiC-like protein; Region: YwiC; pfam14256 288681008589 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 288681008590 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681008591 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 288681008592 Walker A/P-loop; other site 288681008593 ATP binding site [chemical binding]; other site 288681008594 Q-loop/lid; other site 288681008595 ABC transporter signature motif; other site 288681008596 Walker B; other site 288681008597 D-loop; other site 288681008598 H-loop/switch region; other site 288681008599 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681008600 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 288681008601 Walker A/P-loop; other site 288681008602 ATP binding site [chemical binding]; other site 288681008603 Q-loop/lid; other site 288681008604 ABC transporter signature motif; other site 288681008605 Walker B; other site 288681008606 D-loop; other site 288681008607 H-loop/switch region; other site 288681008608 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 288681008609 Calreticulin family; Region: Calreticulin; pfam00262 288681008610 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 288681008611 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 288681008612 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 288681008613 Predicted membrane protein [Function unknown]; Region: COG1288 288681008614 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 288681008615 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681008616 DNA binding residues [nucleotide binding] 288681008617 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681008618 dimer interface [polypeptide binding]; other site 288681008619 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 288681008620 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681008621 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 288681008622 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681008623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008624 non-specific DNA binding site [nucleotide binding]; other site 288681008625 salt bridge; other site 288681008626 sequence-specific DNA binding site [nucleotide binding]; other site 288681008627 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 288681008628 putative deacylase active site [active] 288681008629 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008630 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008631 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681008632 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681008633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681008634 Histidine kinase; Region: HisKA_3; pfam07730 288681008635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681008636 ATP binding site [chemical binding]; other site 288681008637 Mg2+ binding site [ion binding]; other site 288681008638 G-X-G motif; other site 288681008639 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681008640 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681008641 active site 288681008642 phosphorylation site [posttranslational modification] 288681008643 intermolecular recognition site; other site 288681008644 dimerization interface [polypeptide binding]; other site 288681008645 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681008646 DNA binding residues [nucleotide binding] 288681008647 dimerization interface [polypeptide binding]; other site 288681008648 histidyl-tRNA synthetase; Provisional; Region: PRK12420 288681008649 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 288681008650 dimer interface [polypeptide binding]; other site 288681008651 motif 1; other site 288681008652 active site 288681008653 motif 2; other site 288681008654 motif 3; other site 288681008655 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 288681008656 anticodon binding site; other site 288681008657 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681008658 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288681008659 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 288681008660 dimer interface [polypeptide binding]; other site 288681008661 FMN binding site [chemical binding]; other site 288681008662 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 288681008663 pyruvate kinase; Validated; Region: PRK06739 288681008664 active site 288681008665 domain interfaces; other site 288681008666 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 288681008667 classical (c) SDRs; Region: SDR_c; cd05233 288681008668 NAD(P) binding site [chemical binding]; other site 288681008669 active site 288681008670 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681008671 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681008672 Walker A/P-loop; other site 288681008673 ATP binding site [chemical binding]; other site 288681008674 Q-loop/lid; other site 288681008675 ABC transporter signature motif; other site 288681008676 Walker B; other site 288681008677 D-loop; other site 288681008678 H-loop/switch region; other site 288681008679 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 288681008680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681008681 non-specific DNA binding site [nucleotide binding]; other site 288681008682 salt bridge; other site 288681008683 sequence-specific DNA binding site [nucleotide binding]; other site 288681008684 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 288681008685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681008686 motif II; other site 288681008687 Phosphotransferase enzyme family; Region: APH; pfam01636 288681008688 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 288681008689 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 288681008690 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 288681008691 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 288681008692 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681008693 nudix motif; other site 288681008694 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 288681008695 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008696 putative metal binding site [ion binding]; other site 288681008697 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 288681008698 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681008699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 288681008702 putative substrate translocation pore; other site 288681008703 maltose O-acetyltransferase; Provisional; Region: PRK10092 288681008704 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 288681008705 active site 288681008706 substrate binding site [chemical binding]; other site 288681008707 trimer interface [polypeptide binding]; other site 288681008708 CoA binding site [chemical binding]; other site 288681008709 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008710 FtsX-like permease family; Region: FtsX; pfam02687 288681008711 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681008712 FtsX-like permease family; Region: FtsX; pfam02687 288681008713 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681008714 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681008715 Walker A/P-loop; other site 288681008716 ATP binding site [chemical binding]; other site 288681008717 Q-loop/lid; other site 288681008718 ABC transporter signature motif; other site 288681008719 Walker B; other site 288681008720 D-loop; other site 288681008721 H-loop/switch region; other site 288681008722 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 288681008723 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 288681008724 active site 288681008725 HIGH motif; other site 288681008726 dimer interface [polypeptide binding]; other site 288681008727 KMSKS motif; other site 288681008728 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 288681008729 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 288681008730 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 288681008731 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 288681008732 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681008733 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681008734 Predicted membrane protein [Function unknown]; Region: COG2261 288681008735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008736 Coenzyme A binding pocket [chemical binding]; other site 288681008737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288681008738 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681008739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008740 S-adenosylmethionine binding site [chemical binding]; other site 288681008741 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 288681008742 CGNR zinc finger; Region: zf-CGNR; pfam11706 288681008743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008744 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681008745 putative substrate translocation pore; other site 288681008746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681008747 TPR motif; other site 288681008748 TPR repeat; Region: TPR_11; pfam13414 288681008749 binding surface 288681008750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681008751 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681008752 TPR motif; other site 288681008753 binding surface 288681008754 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 288681008755 hypothetical protein; Provisional; Region: PRK04164 288681008756 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 288681008757 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 288681008758 Domain of unknown function DUF21; Region: DUF21; pfam01595 288681008759 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 288681008760 Transporter associated domain; Region: CorC_HlyC; smart01091 288681008761 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 288681008762 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681008763 DNA binding residues [nucleotide binding] 288681008764 putative dimer interface [polypeptide binding]; other site 288681008765 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 288681008766 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 288681008767 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 288681008768 substrate binding site; other site 288681008769 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 288681008770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008771 NAD(P) binding site [chemical binding]; other site 288681008772 active site 288681008773 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 288681008774 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681008775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008776 S-adenosylmethionine binding site [chemical binding]; other site 288681008777 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 288681008778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681008779 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 288681008780 NAD(P) binding site [chemical binding]; other site 288681008781 active site 288681008782 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 288681008783 Variant SH3 domain; Region: SH3_2; pfam07653 288681008784 peptide ligand binding site [polypeptide binding]; other site 288681008785 Src Homology 3 domain superfamily; Region: SH3; cl17036 288681008786 EamA-like transporter family; Region: EamA; pfam00892 288681008787 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681008788 EamA-like transporter family; Region: EamA; pfam00892 288681008789 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 288681008790 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 288681008791 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 288681008792 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 288681008793 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 288681008794 N- and C-terminal domain interface [polypeptide binding]; other site 288681008795 active site 288681008796 catalytic site [active] 288681008797 metal binding site [ion binding]; metal-binding site 288681008798 carbohydrate binding site [chemical binding]; other site 288681008799 ATP binding site [chemical binding]; other site 288681008800 GntP family permease; Region: GntP_permease; pfam02447 288681008801 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288681008802 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 288681008803 active site 288681008804 intersubunit interactions; other site 288681008805 catalytic residue [active] 288681008806 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 288681008807 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288681008808 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 288681008809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 288681008810 TPP-binding site [chemical binding]; other site 288681008811 dimer interface [polypeptide binding]; other site 288681008812 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288681008813 PYR/PP interface [polypeptide binding]; other site 288681008814 dimer interface [polypeptide binding]; other site 288681008815 TPP binding site [chemical binding]; other site 288681008816 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681008817 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 288681008818 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 288681008819 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 288681008820 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 288681008821 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681008822 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 288681008823 putative NAD(P) binding site [chemical binding]; other site 288681008824 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 288681008825 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 288681008826 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 288681008827 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681008828 putative NAD(P) binding site [chemical binding]; other site 288681008829 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288681008830 classical (c) SDRs; Region: SDR_c; cd05233 288681008831 NAD(P) binding site [chemical binding]; other site 288681008832 active site 288681008833 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681008834 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681008835 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681008836 active site 288681008837 Zn binding site [ion binding]; other site 288681008838 Viral enhancin protein; Region: Enhancin; pfam03272 288681008839 Peptidase M60-like family; Region: M60-like; pfam13402 288681008840 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681008841 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681008842 dimerization interface [polypeptide binding]; other site 288681008843 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681008844 dimer interface [polypeptide binding]; other site 288681008845 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 288681008846 putative CheW interface [polypeptide binding]; other site 288681008847 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 288681008848 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 288681008849 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288681008850 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288681008851 catalytic motif [active] 288681008852 Zn binding site [ion binding]; other site 288681008853 RibD C-terminal domain; Region: RibD_C; cl17279 288681008854 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288681008855 dimerization interface [polypeptide binding]; other site 288681008856 active site 288681008857 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681008858 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288681008859 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681008860 dimer interface [polypeptide binding]; other site 288681008861 FMN binding site [chemical binding]; other site 288681008862 BNR repeat-like domain; Region: BNR_2; pfam13088 288681008863 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681008864 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681008865 active site 288681008866 catalytic tetrad [active] 288681008867 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681008868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681008869 putative substrate translocation pore; other site 288681008870 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 288681008871 active site 1 [active] 288681008872 dimer interface [polypeptide binding]; other site 288681008873 hexamer interface [polypeptide binding]; other site 288681008874 active site 2 [active] 288681008875 dimer interface [polypeptide binding]; other site 288681008876 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 288681008877 hexamer interface [polypeptide binding]; other site 288681008878 active site 2 [active] 288681008879 hypothetical protein; Provisional; Region: PRK02487 288681008880 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681008881 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681008882 active site 288681008883 metal binding site [ion binding]; metal-binding site 288681008884 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 288681008885 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 288681008886 IDEAL domain; Region: IDEAL; pfam08858 288681008887 Transcriptional regulator; Region: Rrf2; pfam02082 288681008888 Rrf2 family protein; Region: rrf2_super; TIGR00738 288681008889 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 288681008890 putative catalytic residues [active] 288681008891 thiol/disulfide switch; other site 288681008892 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681008893 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008894 dimerization interface [polypeptide binding]; other site 288681008895 putative DNA binding site [nucleotide binding]; other site 288681008896 putative Zn2+ binding site [ion binding]; other site 288681008897 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681008898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681008899 DNA-binding site [nucleotide binding]; DNA binding site 288681008900 UTRA domain; Region: UTRA; pfam07702 288681008901 putative oxidoreductase; Provisional; Region: PRK10206 288681008902 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681008903 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288681008904 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 288681008905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 288681008906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681008907 S-adenosylmethionine binding site [chemical binding]; other site 288681008908 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681008909 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288681008910 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681008911 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008912 dimerization interface [polypeptide binding]; other site 288681008913 putative DNA binding site [nucleotide binding]; other site 288681008914 putative Zn2+ binding site [ion binding]; other site 288681008915 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681008916 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681008917 active site 288681008918 catalytic tetrad [active] 288681008919 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 288681008920 putative hydrophobic ligand binding site [chemical binding]; other site 288681008921 protein interface [polypeptide binding]; other site 288681008922 gate; other site 288681008923 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 288681008924 catalytic triad [active] 288681008925 oxyanion hole [active] 288681008926 active site 288681008927 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681008928 Phosphotransferase enzyme family; Region: APH; pfam01636 288681008929 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 288681008930 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 288681008931 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 288681008932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681008933 Coenzyme A binding pocket [chemical binding]; other site 288681008934 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681008935 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681008936 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681008937 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681008938 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 288681008939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681008940 acyl-activating enzyme (AAE) consensus motif; other site 288681008941 AMP binding site [chemical binding]; other site 288681008942 active site 288681008943 CoA binding site [chemical binding]; other site 288681008944 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 288681008945 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681008946 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008947 dimerization interface [polypeptide binding]; other site 288681008948 putative DNA binding site [nucleotide binding]; other site 288681008949 putative Zn2+ binding site [ion binding]; other site 288681008950 hypothetical protein; Provisional; Region: PRK08244 288681008951 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288681008952 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681008953 dimerization interface [polypeptide binding]; other site 288681008954 putative DNA binding site [nucleotide binding]; other site 288681008955 putative Zn2+ binding site [ion binding]; other site 288681008956 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 288681008957 active site 288681008958 Glyco_18 domain; Region: Glyco_18; smart00636 288681008959 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 288681008960 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 288681008961 NodB motif; other site 288681008962 putative active site [active] 288681008963 putative catalytic site [active] 288681008964 putative Zn binding site [ion binding]; other site 288681008965 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681008966 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 288681008967 DXD motif; other site 288681008968 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 288681008969 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 288681008970 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681008971 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681008972 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 288681008973 active site 288681008974 CAAX protease self-immunity; Region: Abi; pfam02517 288681008975 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681008976 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681008977 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 288681008978 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 288681008979 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 288681008980 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 288681008981 HTH domain; Region: HTH_11; pfam08279 288681008982 WYL domain; Region: WYL; pfam13280 288681008983 Protein of unknown function (DUF805); Region: DUF805; pfam05656 288681008984 ABC-2 type transporter; Region: ABC2_membrane; cl17235 288681008985 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681008986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681008987 Walker A/P-loop; other site 288681008988 ATP binding site [chemical binding]; other site 288681008989 Q-loop/lid; other site 288681008990 ABC transporter signature motif; other site 288681008991 Walker B; other site 288681008992 D-loop; other site 288681008993 H-loop/switch region; other site 288681008994 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 288681008995 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681008996 hydroxylamine reductase; Provisional; Region: PRK12310 288681008997 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681008998 ACS interaction site; other site 288681008999 CODH interaction site; other site 288681009000 metal cluster binding site [ion binding]; other site 288681009001 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681009002 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 288681009003 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 288681009004 metal binding site [ion binding]; metal-binding site 288681009005 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 288681009006 hypothetical protein; Provisional; Region: PRK06771 288681009007 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681009008 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681009009 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 288681009010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 288681009011 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 288681009012 dimer interface [polypeptide binding]; other site 288681009013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009014 ligand binding site [chemical binding]; other site 288681009015 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 288681009016 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681009017 ligand binding site [chemical binding]; other site 288681009018 flexible hinge region; other site 288681009019 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 288681009020 Protein of unknown function, DUF606; Region: DUF606; pfam04657 288681009021 Protein of unknown function, DUF606; Region: DUF606; pfam04657 288681009022 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 288681009023 Protein of unknown function DUF58; Region: DUF58; pfam01882 288681009024 MoxR-like ATPases [General function prediction only]; Region: COG0714 288681009025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681009026 Walker A motif; other site 288681009027 ATP binding site [chemical binding]; other site 288681009028 Walker B motif; other site 288681009029 arginine finger; other site 288681009030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681009031 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 288681009032 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 288681009033 putative NAD(P) binding site [chemical binding]; other site 288681009034 dimer interface [polypeptide binding]; other site 288681009035 putative transport protein YifK; Provisional; Region: PRK10746 288681009036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009037 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 288681009038 putative substrate translocation pore; other site 288681009039 Haemolysin XhlA; Region: XhlA; pfam10779 288681009040 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 288681009041 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 288681009042 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 288681009043 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 288681009044 transmembrane helices; other site 288681009045 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681009046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681009047 Coenzyme A binding pocket [chemical binding]; other site 288681009048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681009049 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681009050 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681009051 putative ligand binding residues [chemical binding]; other site 288681009052 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681009053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681009054 ABC-ATPase subunit interface; other site 288681009055 dimer interface [polypeptide binding]; other site 288681009056 putative PBP binding regions; other site 288681009057 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681009058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681009059 ABC-ATPase subunit interface; other site 288681009060 dimer interface [polypeptide binding]; other site 288681009061 putative PBP binding regions; other site 288681009062 Protein of unknown function (DUF817); Region: DUF817; pfam05675 288681009063 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 288681009064 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288681009065 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 288681009066 DinB superfamily; Region: DinB_2; pfam12867 288681009067 DinB family; Region: DinB; cl17821 288681009068 CAAX protease self-immunity; Region: Abi; pfam02517 288681009069 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 288681009070 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 288681009071 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681009072 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681009073 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681009074 dimerization interface [polypeptide binding]; other site 288681009075 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681009076 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 288681009077 NADP binding site [chemical binding]; other site 288681009078 dimer interface [polypeptide binding]; other site 288681009079 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681009080 catalytic core [active] 288681009081 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681009082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681009083 Coenzyme A binding pocket [chemical binding]; other site 288681009084 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 288681009085 MutS domain III; Region: MutS_III; pfam05192 288681009086 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681009087 Walker A/P-loop; other site 288681009088 ATP binding site [chemical binding]; other site 288681009089 Q-loop/lid; other site 288681009090 ABC transporter signature motif; other site 288681009091 Walker B; other site 288681009092 D-loop; other site 288681009093 H-loop/switch region; other site 288681009094 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 288681009095 oligoendopeptidase F; Region: pepF; TIGR00181 288681009096 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 288681009097 active site 288681009098 Zn binding site [ion binding]; other site 288681009099 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681009100 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681009101 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009102 putative substrate translocation pore; other site 288681009103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681009104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681009105 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681009106 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 288681009107 putative dimerization interface [polypeptide binding]; other site 288681009108 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 288681009109 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681009110 putative active site [active] 288681009111 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 288681009112 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681009113 active site 288681009114 catalytic site [active] 288681009115 metal binding site [ion binding]; metal-binding site 288681009116 FAD binding domain; Region: FAD_binding_3; pfam01494 288681009117 hypothetical protein; Provisional; Region: PRK07236 288681009118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681009119 dimerization interface [polypeptide binding]; other site 288681009120 putative DNA binding site [nucleotide binding]; other site 288681009121 putative Zn2+ binding site [ion binding]; other site 288681009122 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 288681009123 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 288681009124 putative NAD(P) binding site [chemical binding]; other site 288681009125 Uncharacterized conserved protein [Function unknown]; Region: COG0397 288681009126 hypothetical protein; Validated; Region: PRK00029 288681009127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 288681009128 TPR motif; other site 288681009129 binding surface 288681009130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681009131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681009132 TPR motif; other site 288681009133 binding surface 288681009134 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 288681009135 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 288681009136 Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987 288681009137 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 288681009138 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 288681009139 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 288681009140 Sodium Bile acid symporter family; Region: SBF; cl17470 288681009141 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 288681009142 FAD binding domain; Region: FAD_binding_4; pfam01565 288681009143 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 288681009144 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681009145 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681009146 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 288681009147 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 288681009148 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 288681009149 trimer interface [polypeptide binding]; other site 288681009150 active site 288681009151 substrate binding site [chemical binding]; other site 288681009152 CoA binding site [chemical binding]; other site 288681009153 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 288681009154 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 288681009155 inhibitor-cofactor binding pocket; inhibition site 288681009156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681009157 catalytic residue [active] 288681009158 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681009159 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 288681009160 active site 288681009161 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 288681009162 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681009163 active site 288681009164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681009165 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681009166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 288681009167 enoyl-CoA hydratase; Provisional; Region: PRK06688 288681009168 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681009169 substrate binding site [chemical binding]; other site 288681009170 oxyanion hole (OAH) forming residues; other site 288681009171 trimer interface [polypeptide binding]; other site 288681009172 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 288681009173 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681009174 FOG: PKD repeat [General function prediction only]; Region: COG3291 288681009175 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 288681009176 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681009177 MgtC family; Region: MgtC; pfam02308 288681009178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681009179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681009180 Coenzyme A binding pocket [chemical binding]; other site 288681009181 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 288681009182 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 288681009183 putative metal binding site [ion binding]; other site 288681009184 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 288681009185 active site 288681009186 metal binding site [ion binding]; metal-binding site 288681009187 VanW like protein; Region: VanW; pfam04294 288681009188 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 288681009189 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 288681009190 exonuclease; Provisional; Region: PRK06722 288681009191 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 288681009192 active site 288681009193 catalytic site [active] 288681009194 substrate binding site [chemical binding]; other site 288681009195 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288681009196 DNA-binding site [nucleotide binding]; DNA binding site 288681009197 RNA-binding motif; other site 288681009198 flavodoxin; Provisional; Region: PRK06703 288681009199 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 288681009200 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 288681009201 nudix motif; other site 288681009202 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 288681009203 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 288681009204 trimer interface [polypeptide binding]; other site 288681009205 active site 288681009206 substrate binding site [chemical binding]; other site 288681009207 CoA binding site [chemical binding]; other site 288681009208 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009209 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009210 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009211 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009212 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009213 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009214 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009215 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009216 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009217 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009218 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009219 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009220 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009221 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009222 short chain dehydrogenase; Provisional; Region: PRK06924 288681009223 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 288681009224 NADP binding site [chemical binding]; other site 288681009225 homodimer interface [polypeptide binding]; other site 288681009226 active site 288681009227 Predicted acetyltransferase [General function prediction only]; Region: COG3393 288681009228 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681009229 argininosuccinate lyase; Provisional; Region: PRK06705 288681009230 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 288681009231 active sites [active] 288681009232 tetramer interface [polypeptide binding]; other site 288681009233 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 288681009234 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 288681009235 Phage integrase, N-terminal SAM-like domain; Region: Phage_int_SAM_1; cl12235 288681009236 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 288681009237 active site 288681009238 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681009239 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 288681009240 Na binding site [ion binding]; other site 288681009241 Protein of unknown function (DUF997); Region: DUF997; pfam06196 288681009242 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 288681009243 NAD(P) binding site [chemical binding]; other site 288681009244 catalytic residues [active] 288681009245 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 288681009246 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 288681009247 NAD(P) binding site [chemical binding]; other site 288681009248 homotetramer interface [polypeptide binding]; other site 288681009249 homodimer interface [polypeptide binding]; other site 288681009250 active site 288681009251 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 288681009252 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 288681009253 Divergent PAP2 family; Region: DUF212; pfam02681 288681009254 Predicted permeases [General function prediction only]; Region: RarD; COG2962 288681009255 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 288681009256 antiporter inner membrane protein; Provisional; Region: PRK11670 288681009257 Domain of unknown function DUF59; Region: DUF59; pfam01883 288681009258 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 288681009259 Walker A motif; other site 288681009260 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 288681009261 MoaE interaction surface [polypeptide binding]; other site 288681009262 MoeB interaction surface [polypeptide binding]; other site 288681009263 thiocarboxylated glycine; other site 288681009264 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288681009265 MoaE homodimer interface [polypeptide binding]; other site 288681009266 MoaD interaction [polypeptide binding]; other site 288681009267 active site residues [active] 288681009268 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288681009269 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288681009270 dimer interface [polypeptide binding]; other site 288681009271 putative functional site; other site 288681009272 putative MPT binding site; other site 288681009273 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 288681009274 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681009275 ATP binding site [chemical binding]; other site 288681009276 substrate interface [chemical binding]; other site 288681009277 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 288681009278 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 288681009279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681009280 FeS/SAM binding site; other site 288681009281 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288681009282 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 288681009283 Uncharacterized conserved protein [Function unknown]; Region: COG5609 288681009284 Uncharacterized conserved protein [Function unknown]; Region: COG2427 288681009285 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 288681009286 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 288681009287 catalytic loop [active] 288681009288 iron binding site [ion binding]; other site 288681009289 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 288681009290 4Fe-4S binding domain; Region: Fer4; pfam00037 288681009291 4Fe-4S binding domain; Region: Fer4; pfam00037 288681009292 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 288681009293 [4Fe-4S] binding site [ion binding]; other site 288681009294 molybdopterin cofactor binding site; other site 288681009295 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 288681009296 molybdopterin cofactor binding site; other site 288681009297 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681009298 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 288681009299 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681009300 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681009301 Tubulin like; Region: Tubulin_2; pfam13809 288681009302 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 288681009303 metal ion-dependent adhesion site (MIDAS); other site 288681009304 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009305 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681009306 active site 288681009307 metal binding site [ion binding]; metal-binding site 288681009308 Methyltransferase domain; Region: Methyltransf_31; pfam13847 288681009309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681009310 S-adenosylmethionine binding site [chemical binding]; other site 288681009311 O-methyltransferase; Region: Methyltransf_2; pfam00891 288681009312 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681009313 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681009314 peptide binding site [polypeptide binding]; other site 288681009315 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681009316 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681009317 peptide binding site [polypeptide binding]; other site 288681009318 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 288681009319 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 288681009320 peptide binding site [polypeptide binding]; other site 288681009321 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 288681009322 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681009323 Transcriptional regulator [Transcription]; Region: LytR; COG1316 288681009324 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 288681009325 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681009326 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681009327 DNA binding residues [nucleotide binding] 288681009328 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 288681009329 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681009330 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681009331 Walker A/P-loop; other site 288681009332 ATP binding site [chemical binding]; other site 288681009333 Q-loop/lid; other site 288681009334 ABC transporter signature motif; other site 288681009335 Walker B; other site 288681009336 D-loop; other site 288681009337 H-loop/switch region; other site 288681009338 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681009339 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681009340 putative oxidoreductase; Provisional; Region: PRK11579 288681009341 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681009342 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288681009343 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 288681009344 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 288681009345 CAP-like domain; other site 288681009346 active site 288681009347 primary dimer interface [polypeptide binding]; other site 288681009348 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681009349 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681009350 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681009351 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 288681009352 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 288681009353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681009354 ATP binding site [chemical binding]; other site 288681009355 Mg2+ binding site [ion binding]; other site 288681009356 G-X-G motif; other site 288681009357 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 288681009358 anchoring element; other site 288681009359 dimer interface [polypeptide binding]; other site 288681009360 ATP binding site [chemical binding]; other site 288681009361 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 288681009362 active site 288681009363 putative metal-binding site [ion binding]; other site 288681009364 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 288681009365 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 288681009366 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 288681009367 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288681009368 protein binding site [polypeptide binding]; other site 288681009369 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681009370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681009371 active site 288681009372 phosphorylation site [posttranslational modification] 288681009373 intermolecular recognition site; other site 288681009374 dimerization interface [polypeptide binding]; other site 288681009375 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681009376 DNA binding site [nucleotide binding] 288681009377 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 288681009378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681009379 FeS/SAM binding site; other site 288681009380 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 288681009381 Class III ribonucleotide reductase; Region: RNR_III; cd01675 288681009382 effector binding site; other site 288681009383 active site 288681009384 Zn binding site [ion binding]; other site 288681009385 glycine loop; other site 288681009386 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 288681009387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 288681009388 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288681009389 active site 288681009390 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 288681009391 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681009392 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681009393 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 288681009394 active site 288681009395 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 288681009396 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 288681009397 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681009398 active site 288681009399 catalytic site [active] 288681009400 substrate binding site [chemical binding]; other site 288681009401 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 288681009402 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 288681009403 catalytic residues [active] 288681009404 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681009405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681009406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681009407 Walker A/P-loop; other site 288681009408 ATP binding site [chemical binding]; other site 288681009409 Q-loop/lid; other site 288681009410 ABC transporter signature motif; other site 288681009411 Walker B; other site 288681009412 D-loop; other site 288681009413 H-loop/switch region; other site 288681009414 aconitate hydratase; Validated; Region: PRK09277 288681009415 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 288681009416 substrate binding site [chemical binding]; other site 288681009417 ligand binding site [chemical binding]; other site 288681009418 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 288681009419 substrate binding site [chemical binding]; other site 288681009420 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681009421 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 288681009422 NodB motif; other site 288681009423 active site 288681009424 catalytic site [active] 288681009425 metal binding site [ion binding]; metal-binding site 288681009426 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 288681009427 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 288681009428 putative dimer interface [polypeptide binding]; other site 288681009429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681009431 putative substrate translocation pore; other site 288681009432 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 288681009433 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 288681009434 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681009435 nudix motif; other site 288681009436 SAP domain; Region: SAP; pfam02037 288681009437 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 288681009438 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681009439 dimer interface [polypeptide binding]; other site 288681009440 active site 288681009441 acyl-CoA synthetase; Validated; Region: PRK07638 288681009442 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681009443 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681009444 acyl-activating enzyme (AAE) consensus motif; other site 288681009445 acyl-activating enzyme (AAE) consensus motif; other site 288681009446 AMP binding site [chemical binding]; other site 288681009447 active site 288681009448 CoA binding site [chemical binding]; other site 288681009449 BioY family; Region: BioY; pfam02632 288681009450 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 288681009451 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 288681009452 dimer interface [polypeptide binding]; other site 288681009453 acyl-activating enzyme (AAE) consensus motif; other site 288681009454 putative active site [active] 288681009455 AMP binding site [chemical binding]; other site 288681009456 putative CoA binding site [chemical binding]; other site 288681009457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681009458 Coenzyme A binding pocket [chemical binding]; other site 288681009459 S-layer homology domain; Region: SLH; pfam00395 288681009460 S-layer homology domain; Region: SLH; pfam00395 288681009461 S-layer homology domain; Region: SLH; pfam00395 288681009462 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681009463 active site 288681009464 catalytic motif [active] 288681009465 Zn binding site [ion binding]; other site 288681009466 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 288681009467 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681009468 amidase catalytic site [active] 288681009469 Zn binding residues [ion binding]; other site 288681009470 substrate binding site [chemical binding]; other site 288681009471 active site 288681009472 Protein phosphatase 2C; Region: PP2C_2; pfam13672 288681009473 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681009474 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681009475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009476 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 288681009477 dimer interface [polypeptide binding]; other site 288681009478 putative metal binding site [ion binding]; other site 288681009479 PAS domain S-box; Region: sensory_box; TIGR00229 288681009480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681009481 putative active site [active] 288681009482 heme pocket [chemical binding]; other site 288681009483 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 288681009484 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681009485 putative active site [active] 288681009486 heme pocket [chemical binding]; other site 288681009487 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681009488 dimer interface [polypeptide binding]; other site 288681009489 phosphorylation site [posttranslational modification] 288681009490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681009491 ATP binding site [chemical binding]; other site 288681009492 Mg2+ binding site [ion binding]; other site 288681009493 G-X-G motif; other site 288681009494 Predicted esterase [General function prediction only]; Region: COG0400 288681009495 putative hydrolase; Provisional; Region: PRK11460 288681009496 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681009497 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009498 Zn binding site [ion binding]; other site 288681009499 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681009500 Zn binding site [ion binding]; other site 288681009501 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 288681009502 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 288681009503 Na binding site [ion binding]; other site 288681009504 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 288681009505 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 288681009506 active site 288681009507 FMN binding site [chemical binding]; other site 288681009508 substrate binding site [chemical binding]; other site 288681009509 3Fe-4S cluster binding site [ion binding]; other site 288681009510 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 288681009511 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 288681009512 FMN binding site [chemical binding]; other site 288681009513 active site 288681009514 substrate binding site [chemical binding]; other site 288681009515 catalytic residue [active] 288681009516 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 288681009517 agmatinase; Region: agmatinase; TIGR01230 288681009518 Agmatinase-like family; Region: Agmatinase-like; cd09990 288681009519 active site 288681009520 oligomer interface [polypeptide binding]; other site 288681009521 Mn binding site [ion binding]; other site 288681009522 imidazolonepropionase; Validated; Region: PRK09356 288681009523 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 288681009524 active site 288681009525 urocanate hydratase; Provisional; Region: PRK05414 288681009526 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 288681009527 active sites [active] 288681009528 tetramer interface [polypeptide binding]; other site 288681009529 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 288681009530 hexamer interface [polypeptide binding]; other site 288681009531 RNA binding site [nucleotide binding]; other site 288681009532 Histidine-zinc binding site [chemical binding]; other site 288681009533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681009534 S-adenosylmethionine binding site [chemical binding]; other site 288681009535 DJ-1 family protein; Region: not_thiJ; TIGR01383 288681009536 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 288681009537 conserved cys residue [active] 288681009538 AAA domain; Region: AAA_28; pfam13521 288681009539 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 288681009540 active site 288681009541 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 288681009542 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009543 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009544 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009545 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009546 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009547 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009548 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009549 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009550 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009551 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009552 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009553 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009554 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009555 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009556 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009557 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009558 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009559 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009560 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681009561 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 288681009562 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 288681009563 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 288681009564 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681009565 EamA-like transporter family; Region: EamA; pfam00892 288681009566 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 288681009567 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 288681009568 metal binding site [ion binding]; metal-binding site 288681009569 dimer interface [polypeptide binding]; other site 288681009570 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 288681009571 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681009572 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681009573 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681009574 Walker A/P-loop; other site 288681009575 ATP binding site [chemical binding]; other site 288681009576 Q-loop/lid; other site 288681009577 ABC transporter signature motif; other site 288681009578 Walker B; other site 288681009579 D-loop; other site 288681009580 H-loop/switch region; other site 288681009581 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 288681009582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681009583 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 288681009584 putative dimerization interface [polypeptide binding]; other site 288681009585 putative substrate binding pocket [chemical binding]; other site 288681009586 holin-like protein; Validated; Region: PRK01658 288681009587 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 288681009588 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681009589 nudix motif; other site 288681009590 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 288681009591 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681009592 S-layer homology domain; Region: SLH; pfam00395 288681009593 S-layer homology domain; Region: SLH; pfam00395 288681009594 S-layer homology domain; Region: SLH; pfam00395 288681009595 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681009596 amidase catalytic site [active] 288681009597 Zn binding residues [ion binding]; other site 288681009598 substrate binding site [chemical binding]; other site 288681009599 Nuclease-related domain; Region: NERD; pfam08378 288681009600 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681009601 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681009602 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 288681009603 Walker A/P-loop; other site 288681009604 ATP binding site [chemical binding]; other site 288681009605 Q-loop/lid; other site 288681009606 ABC transporter signature motif; other site 288681009607 Walker B; other site 288681009608 D-loop; other site 288681009609 H-loop/switch region; other site 288681009610 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681009611 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 288681009612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681009613 Walker A/P-loop; other site 288681009614 ATP binding site [chemical binding]; other site 288681009615 Q-loop/lid; other site 288681009616 ABC transporter signature motif; other site 288681009617 Walker B; other site 288681009618 D-loop; other site 288681009619 H-loop/switch region; other site 288681009620 hypothetical protein; Provisional; Region: PRK01844 288681009621 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 288681009622 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 288681009623 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 288681009624 TPP-binding site [chemical binding]; other site 288681009625 dimer interface [polypeptide binding]; other site 288681009626 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288681009627 PYR/PP interface [polypeptide binding]; other site 288681009628 dimer interface [polypeptide binding]; other site 288681009629 TPP binding site [chemical binding]; other site 288681009630 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681009631 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288681009632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681009633 dimer interface [polypeptide binding]; other site 288681009634 conserved gate region; other site 288681009635 ABC-ATPase subunit interface; other site 288681009636 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 288681009637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681009638 dimer interface [polypeptide binding]; other site 288681009639 conserved gate region; other site 288681009640 ABC-ATPase subunit interface; other site 288681009641 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 288681009642 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 288681009643 Walker A/P-loop; other site 288681009644 ATP binding site [chemical binding]; other site 288681009645 Q-loop/lid; other site 288681009646 ABC transporter signature motif; other site 288681009647 Walker B; other site 288681009648 D-loop; other site 288681009649 H-loop/switch region; other site 288681009650 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 288681009651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681009652 membrane-bound complex binding site; other site 288681009653 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681009654 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 288681009655 active site 288681009656 metal binding site [ion binding]; metal-binding site 288681009657 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681009658 hypothetical protein; Provisional; Region: PRK01546 288681009659 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681009660 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 288681009661 catalytic residues [active] 288681009662 catalytic nucleophile [active] 288681009663 LexA repressor; Validated; Region: PRK00215 288681009664 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681009665 putative DNA binding site [nucleotide binding]; other site 288681009666 putative Zn2+ binding site [ion binding]; other site 288681009667 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 288681009668 Catalytic site [active] 288681009669 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 288681009670 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681009671 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 288681009672 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681009673 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681009674 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681009675 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 288681009676 Helix-turn-helix domain; Region: HTH_17; pfam12728 288681009677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681009678 Walker A/P-loop; other site 288681009679 ATP binding site [chemical binding]; other site 288681009680 Q-loop/lid; other site 288681009681 AAA domain; Region: AAA_21; pfam13304 288681009682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681009683 ABC transporter signature motif; other site 288681009684 Walker B; other site 288681009685 D-loop; other site 288681009686 H-loop/switch region; other site 288681009687 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 288681009688 amidase catalytic site [active] 288681009689 Zn binding residues [ion binding]; other site 288681009690 substrate binding site [chemical binding]; other site 288681009691 Bacterial SH3 domain homologues; Region: SH3b; smart00287 288681009692 Haemolysin XhlA; Region: XhlA; pfam10779 288681009693 prophage LambdaBa01 288681009694 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 288681009695 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 288681009696 Phage tail protein; Region: Sipho_tail; pfam05709 288681009697 Phage tail protein; Region: Sipho_tail; cl17486 288681009698 Phage-related protein [Function unknown]; Region: COG5412 288681009699 membrane protein P6; Region: PHA01399 288681009700 prophage LambdaBa04 fragment 288681009701 Phage-related minor tail protein [Function unknown]; Region: COG5280 288681009702 prophage pi2 fragment 288681009703 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 288681009704 DsrH like protein; Region: DsrH; cl17347 288681009705 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 288681009706 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 288681009707 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 288681009708 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 288681009709 Phage capsid family; Region: Phage_capsid; pfam05065 288681009710 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 288681009711 Phage portal protein; Region: Phage_portal; pfam04860 288681009712 Phage-related protein [Function unknown]; Region: COG4695; cl01923 288681009713 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 288681009714 N-terminal catalytic domain of GIY-YIG intron endonuclease I-TevI, I-BmoI, I-BanI, I-BthII and similar proteins; Region: GIY-YIG_HE_I-TevI_like; cd10437 288681009715 GIY-YIG motif/motif A; other site 288681009716 putative active site [active] 288681009717 catalytic site [active] 288681009718 putative metal binding site [ion binding]; other site 288681009719 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 288681009720 DNA binding site [nucleotide binding] 288681009721 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 288681009722 HNH endonuclease; Region: HNH; pfam01844 288681009723 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 288681009724 Helix-turn-helix domain; Region: HTH_17; pfam12728 288681009725 HNH endonuclease; Region: HNH_2; pfam13391 288681009726 Uncharacterized conserved protein [Function unknown]; Region: COG1479 288681009727 Protein of unknown function DUF262; Region: DUF262; pfam03235 288681009728 Protein of unknown function DUF262; Region: DUF262; pfam03235 288681009729 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 288681009730 HNH endonuclease; Region: HNH_5; pfam14279 288681009731 positive control sigma-like factor; Validated; Region: PRK06930 288681009732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681009733 DNA binding residues [nucleotide binding] 288681009734 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 288681009735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681009736 binding surface 288681009737 TPR motif; other site 288681009738 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 288681009739 Restriction endonuclease; Region: Mrr_cat; pfam04471 288681009740 Thymidylate synthase complementing protein; Region: Thy1; cl03630 288681009741 dUTPase; Region: dUTPase_2; pfam08761 288681009742 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 288681009743 active site 288681009744 homodimer interface [polypeptide binding]; other site 288681009745 metal binding site [ion binding]; metal-binding site 288681009746 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 288681009747 Uncharacterized Zn-finger containing protein [General function prediction only]; Region: COG1645 288681009748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681009749 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681009750 Walker A motif; other site 288681009751 ATP binding site [chemical binding]; other site 288681009752 Walker B motif; other site 288681009753 phage conserved hypothetical protein, C-terminal domain; Region: phg_TIGR02220 288681009754 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 288681009755 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 288681009756 Domain of unknown function (DUF771); Region: DUF771; pfam05595 288681009757 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 288681009758 ORF6C domain; Region: ORF6C; pfam10552 288681009759 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681009760 sequence-specific DNA binding site [nucleotide binding]; other site 288681009761 salt bridge; other site 288681009762 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681009763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681009764 non-specific DNA binding site [nucleotide binding]; other site 288681009765 salt bridge; other site 288681009766 sequence-specific DNA binding site [nucleotide binding]; other site 288681009767 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 288681009768 Domain of unknown function (DUF955); Region: DUF955; cl01076 288681009769 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 288681009770 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 288681009771 Int/Topo IB signature motif; other site 288681009772 glutamine synthetase, type I; Region: GlnA; TIGR00653 288681009773 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 288681009774 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 288681009775 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 288681009776 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681009777 DNA binding residues [nucleotide binding] 288681009778 putative dimer interface [polypeptide binding]; other site 288681009779 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 288681009780 Aluminium resistance protein; Region: Alum_res; pfam06838 288681009781 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 288681009782 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 288681009783 HflX GTPase family; Region: HflX; cd01878 288681009784 G1 box; other site 288681009785 GTP/Mg2+ binding site [chemical binding]; other site 288681009786 Switch I region; other site 288681009787 G2 box; other site 288681009788 G3 box; other site 288681009789 Switch II region; other site 288681009790 G4 box; other site 288681009791 G5 box; other site 288681009792 Predicted membrane protein [Function unknown]; Region: COG2860 288681009793 UPF0126 domain; Region: UPF0126; pfam03458 288681009794 UPF0126 domain; Region: UPF0126; pfam03458 288681009795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681009796 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681009797 Walker A motif; other site 288681009798 ATP binding site [chemical binding]; other site 288681009799 Walker B motif; other site 288681009800 arginine finger; other site 288681009801 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 288681009802 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 288681009803 active site 288681009804 catalytic residues [active] 288681009805 DNA binding site [nucleotide binding] 288681009806 Int/Topo IB signature motif; other site 288681009807 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 288681009808 bacterial Hfq-like; Region: Hfq; cd01716 288681009809 hexamer interface [polypeptide binding]; other site 288681009810 Sm1 motif; other site 288681009811 RNA binding site [nucleotide binding]; other site 288681009812 Sm2 motif; other site 288681009813 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 288681009814 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 288681009815 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681009816 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681009817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 288681009818 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 288681009819 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 288681009820 active site 288681009821 phosphorylation site [posttranslational modification] 288681009822 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 288681009823 active site 288681009824 P-loop; other site 288681009825 phosphorylation site [posttranslational modification] 288681009826 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 288681009827 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 288681009828 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 288681009829 putative substrate binding site [chemical binding]; other site 288681009830 putative ATP binding site [chemical binding]; other site 288681009831 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681009832 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 288681009833 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288681009834 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 288681009835 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 288681009836 dimer interface [polypeptide binding]; other site 288681009837 active site 288681009838 metal binding site [ion binding]; metal-binding site 288681009839 Predicted membrane protein [Function unknown]; Region: COG2322 288681009840 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 288681009841 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 288681009842 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 288681009843 Glyco_18 domain; Region: Glyco_18; smart00636 288681009844 putative active site [active] 288681009845 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681009846 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681009847 putative active site [active] 288681009848 putative metal binding site [ion binding]; other site 288681009849 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 288681009850 histone-like DNA-binding protein HU; Region: HU; cd13831 288681009851 dimer interface [polypeptide binding]; other site 288681009852 DNA binding site [nucleotide binding] 288681009853 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288681009854 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681009855 metal-binding site [ion binding] 288681009856 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 288681009857 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681009858 metal-binding site [ion binding] 288681009859 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681009860 Soluble P-type ATPase [General function prediction only]; Region: COG4087 288681009861 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 288681009862 metal-binding site [ion binding] 288681009863 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 288681009864 putative homodimer interface [polypeptide binding]; other site 288681009865 putative homotetramer interface [polypeptide binding]; other site 288681009866 putative allosteric switch controlling residues; other site 288681009867 putative metal binding site [ion binding]; other site 288681009868 putative homodimer-homodimer interface [polypeptide binding]; other site 288681009869 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 288681009870 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681009871 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681009872 Walker A/P-loop; other site 288681009873 ATP binding site [chemical binding]; other site 288681009874 Q-loop/lid; other site 288681009875 ABC transporter signature motif; other site 288681009876 Walker B; other site 288681009877 D-loop; other site 288681009878 H-loop/switch region; other site 288681009879 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681009880 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681009881 ABC-ATPase subunit interface; other site 288681009882 dimer interface [polypeptide binding]; other site 288681009883 putative PBP binding regions; other site 288681009884 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681009885 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681009886 ABC-ATPase subunit interface; other site 288681009887 dimer interface [polypeptide binding]; other site 288681009888 putative PBP binding regions; other site 288681009889 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681009890 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681009891 putative ligand binding residues [chemical binding]; other site 288681009892 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 288681009893 active site 288681009894 putative catalytic site [active] 288681009895 DNA binding site [nucleotide binding] 288681009896 putative phosphate binding site [ion binding]; other site 288681009897 metal binding site A [ion binding]; metal-binding site 288681009898 AP binding site [nucleotide binding]; other site 288681009899 metal binding site B [ion binding]; metal-binding site 288681009900 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 288681009901 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 288681009902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681009903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681009904 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 288681009905 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 288681009906 DNA binding site [nucleotide binding] 288681009907 active site 288681009908 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 288681009909 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 288681009910 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 288681009911 minor groove reading motif; other site 288681009912 helix-hairpin-helix signature motif; other site 288681009913 substrate binding pocket [chemical binding]; other site 288681009914 active site 288681009915 peptidase T; Region: peptidase-T; TIGR01882 288681009916 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 288681009917 metal binding site [ion binding]; metal-binding site 288681009918 dimer interface [polypeptide binding]; other site 288681009919 Predicted membrane protein [Function unknown]; Region: COG2364 288681009920 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681009921 hypothetical protein; Provisional; Region: PRK06764 288681009922 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681009923 catalytic core [active] 288681009924 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681009925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681009926 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681009927 active site 288681009928 PAS domain S-box; Region: sensory_box; TIGR00229 288681009929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681009930 putative active site [active] 288681009931 heme pocket [chemical binding]; other site 288681009932 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681009933 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681009934 metal binding site [ion binding]; metal-binding site 288681009935 active site 288681009936 I-site; other site 288681009937 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681009938 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 288681009939 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 288681009940 LrgA family; Region: LrgA; cl00608 288681009941 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681009942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681009943 DNA-binding site [nucleotide binding]; DNA binding site 288681009944 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681009945 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681009946 homodimer interface [polypeptide binding]; other site 288681009947 catalytic residue [active] 288681009948 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 288681009949 active site 288681009950 catalytic site [active] 288681009951 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 288681009952 putative active site [active] 288681009953 putative catalytic triad [active] 288681009954 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681009955 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681009956 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 288681009957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681009958 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681009959 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 288681009960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681009961 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681009962 Sulfatase; Region: Sulfatase; pfam00884 288681009963 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681009964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681009965 binding surface 288681009966 TPR motif; other site 288681009967 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 288681009968 G1 box; other site 288681009969 GTP/Mg2+ binding site [chemical binding]; other site 288681009970 Switch I region; other site 288681009971 G3 box; other site 288681009972 Switch II region; other site 288681009973 G4 box; other site 288681009974 G5 box; other site 288681009975 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681009976 dimerization interface [polypeptide binding]; other site 288681009977 putative DNA binding site [nucleotide binding]; other site 288681009978 putative Zn2+ binding site [ion binding]; other site 288681009979 hypothetical protein; Validated; Region: PRK08223 288681009980 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 288681009981 ATP binding site [chemical binding]; other site 288681009982 substrate interface [chemical binding]; other site 288681009983 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 288681009984 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 288681009985 substrate binding site [chemical binding]; other site 288681009986 active site 288681009987 cosubstrate binding site; other site 288681009988 catalytic site [active] 288681009989 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cd08370 288681009990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009991 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681009992 putative substrate translocation pore; other site 288681009993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681009994 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 288681009995 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 288681009996 tetramer interface [polypeptide binding]; other site 288681009997 active site 288681009998 Mg2+/Mn2+ binding site [ion binding]; other site 288681009999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681010000 putative DNA binding site [nucleotide binding]; other site 288681010001 putative Zn2+ binding site [ion binding]; other site 288681010002 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 288681010003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681010004 ATP binding site [chemical binding]; other site 288681010005 Mg2+ binding site [ion binding]; other site 288681010006 G-X-G motif; other site 288681010007 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 288681010008 ATP binding site [chemical binding]; other site 288681010009 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 288681010010 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 288681010011 MutS domain I; Region: MutS_I; pfam01624 288681010012 MutS domain II; Region: MutS_II; pfam05188 288681010013 MutS domain III; Region: MutS_III; pfam05192 288681010014 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 288681010015 Walker A/P-loop; other site 288681010016 ATP binding site [chemical binding]; other site 288681010017 Q-loop/lid; other site 288681010018 ABC transporter signature motif; other site 288681010019 Walker B; other site 288681010020 D-loop; other site 288681010021 H-loop/switch region; other site 288681010022 Outer spore coat protein E (CotE); Region: CotE; pfam10628 288681010023 Predicted membrane protein [Function unknown]; Region: COG4550 288681010024 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 288681010025 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 288681010026 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681010027 FeS/SAM binding site; other site 288681010028 TRAM domain; Region: TRAM; pfam01938 288681010029 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 288681010030 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 288681010031 TPP-binding site [chemical binding]; other site 288681010032 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 288681010033 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 288681010034 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 288681010035 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 288681010036 dimer interface [polypeptide binding]; other site 288681010037 PYR/PP interface [polypeptide binding]; other site 288681010038 TPP binding site [chemical binding]; other site 288681010039 substrate binding site [chemical binding]; other site 288681010040 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681010041 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 288681010042 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 288681010043 active site 288681010044 dimer interface [polypeptide binding]; other site 288681010045 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 288681010046 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 288681010047 putative active site [active] 288681010048 metal binding site [ion binding]; metal-binding site 288681010049 homodimer binding site [polypeptide binding]; other site 288681010050 phosphodiesterase; Provisional; Region: PRK12704 288681010051 Uncharacterized conserved protein [Function unknown]; Region: COG3334 288681010052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681010053 Zn2+ binding site [ion binding]; other site 288681010054 Mg2+ binding site [ion binding]; other site 288681010055 recA bacterial DNA recombination protein; Region: RecA; cl19152 288681010056 recA bacterial DNA recombination protein; Region: RecA; cl17211 288681010057 competence damage-inducible protein A; Provisional; Region: PRK00549 288681010058 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 288681010059 putative MPT binding site; other site 288681010060 Competence-damaged protein; Region: CinA; pfam02464 288681010061 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 288681010062 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 288681010063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681010064 non-specific DNA binding site [nucleotide binding]; other site 288681010065 salt bridge; other site 288681010066 sequence-specific DNA binding site [nucleotide binding]; other site 288681010067 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 288681010068 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 288681010069 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 288681010070 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 288681010071 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 288681010072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010073 NAD(P) binding site [chemical binding]; other site 288681010074 active site 288681010075 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288681010076 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 288681010077 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288681010078 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288681010079 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288681010080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288681010081 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 288681010082 TM-ABC transporter signature motif; other site 288681010083 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 288681010084 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 288681010085 TM-ABC transporter signature motif; other site 288681010086 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 288681010087 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 288681010088 Walker A/P-loop; other site 288681010089 ATP binding site [chemical binding]; other site 288681010090 Q-loop/lid; other site 288681010091 ABC transporter signature motif; other site 288681010092 Walker B; other site 288681010093 D-loop; other site 288681010094 H-loop/switch region; other site 288681010095 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 288681010096 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 288681010097 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 288681010098 ligand binding site [chemical binding]; other site 288681010099 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681010100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681010101 DNA-binding site [nucleotide binding]; DNA binding site 288681010102 UTRA domain; Region: UTRA; pfam07702 288681010103 Tetraspanin family; Region: Tetraspannin; pfam00335 288681010104 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 288681010105 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 288681010106 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 288681010107 YlzJ-like protein; Region: YlzJ; pfam14035 288681010108 Clp protease; Region: CLP_protease; pfam00574 288681010109 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 288681010110 active site 288681010111 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288681010112 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681010113 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 288681010114 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 288681010115 dimer interface [polypeptide binding]; other site 288681010116 active site 288681010117 catalytic residue [active] 288681010118 aspartate kinase I; Reviewed; Region: PRK08210 288681010119 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 288681010120 nucleotide binding site [chemical binding]; other site 288681010121 substrate binding site [chemical binding]; other site 288681010122 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 288681010123 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 288681010124 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 288681010125 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 288681010126 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 288681010127 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 288681010128 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 288681010129 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 288681010130 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 288681010131 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 288681010132 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 288681010133 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 288681010134 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 288681010135 NodB motif; other site 288681010136 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 288681010137 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 288681010138 RNase E interface [polypeptide binding]; other site 288681010139 trimer interface [polypeptide binding]; other site 288681010140 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 288681010141 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 288681010142 RNase E interface [polypeptide binding]; other site 288681010143 trimer interface [polypeptide binding]; other site 288681010144 active site 288681010145 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 288681010146 putative nucleic acid binding region [nucleotide binding]; other site 288681010147 G-X-X-G motif; other site 288681010148 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 288681010149 RNA binding site [nucleotide binding]; other site 288681010150 domain interface; other site 288681010151 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 288681010152 16S/18S rRNA binding site [nucleotide binding]; other site 288681010153 S13e-L30e interaction site [polypeptide binding]; other site 288681010154 25S rRNA binding site [nucleotide binding]; other site 288681010155 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 288681010156 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 288681010157 active site 288681010158 Riboflavin kinase; Region: Flavokinase; smart00904 288681010159 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 288681010160 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 288681010161 RNA binding site [nucleotide binding]; other site 288681010162 active site 288681010163 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 288681010164 Protein of unknown function (DUF503); Region: DUF503; pfam04456 288681010165 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 288681010166 translation initiation factor IF-2; Region: IF-2; TIGR00487 288681010167 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 288681010168 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 288681010169 G1 box; other site 288681010170 putative GEF interaction site [polypeptide binding]; other site 288681010171 GTP/Mg2+ binding site [chemical binding]; other site 288681010172 Switch I region; other site 288681010173 G2 box; other site 288681010174 G3 box; other site 288681010175 Switch II region; other site 288681010176 G4 box; other site 288681010177 G5 box; other site 288681010178 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 288681010179 Translation-initiation factor 2; Region: IF-2; pfam11987 288681010180 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 288681010181 hypothetical protein; Provisional; Region: PRK07714 288681010182 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 288681010183 putative RNA binding cleft [nucleotide binding]; other site 288681010184 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 288681010185 NusA N-terminal domain; Region: NusA_N; pfam08529 288681010186 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 288681010187 RNA binding site [nucleotide binding]; other site 288681010188 homodimer interface [polypeptide binding]; other site 288681010189 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 288681010190 G-X-X-G motif; other site 288681010191 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 288681010192 G-X-X-G motif; other site 288681010193 Sm and related proteins; Region: Sm_like; cl00259 288681010194 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 288681010195 putative oligomer interface [polypeptide binding]; other site 288681010196 putative RNA binding site [nucleotide binding]; other site 288681010197 DNA polymerase III PolC; Validated; Region: polC; PRK00448 288681010198 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 288681010199 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 288681010200 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 288681010201 generic binding surface II; other site 288681010202 generic binding surface I; other site 288681010203 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 288681010204 active site 288681010205 putative PHP Thumb interface [polypeptide binding]; other site 288681010206 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 288681010207 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 288681010208 prolyl-tRNA synthetase; Provisional; Region: PRK09194 288681010209 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 288681010210 dimer interface [polypeptide binding]; other site 288681010211 motif 1; other site 288681010212 active site 288681010213 motif 2; other site 288681010214 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 288681010215 putative deacylase active site [active] 288681010216 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 288681010217 active site 288681010218 motif 3; other site 288681010219 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 288681010220 anticodon binding site; other site 288681010221 RIP metalloprotease RseP; Region: TIGR00054 288681010222 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 288681010223 active site 288681010224 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 288681010225 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 288681010226 protein binding site [polypeptide binding]; other site 288681010227 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 288681010228 putative substrate binding region [chemical binding]; other site 288681010229 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 288681010230 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 288681010231 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 288681010232 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 288681010233 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 288681010234 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 288681010235 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 288681010236 catalytic residue [active] 288681010237 putative FPP diphosphate binding site; other site 288681010238 putative FPP binding hydrophobic cleft; other site 288681010239 dimer interface [polypeptide binding]; other site 288681010240 putative IPP diphosphate binding site; other site 288681010241 ribosome recycling factor; Reviewed; Region: frr; PRK00083 288681010242 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 288681010243 hinge region; other site 288681010244 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 288681010245 putative nucleotide binding site [chemical binding]; other site 288681010246 uridine monophosphate binding site [chemical binding]; other site 288681010247 homohexameric interface [polypeptide binding]; other site 288681010248 elongation factor Ts; Provisional; Region: tsf; PRK09377 288681010249 UBA/TS-N domain; Region: UBA; pfam00627 288681010250 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 288681010251 rRNA interaction site [nucleotide binding]; other site 288681010252 S8 interaction site; other site 288681010253 putative laminin-1 binding site; other site 288681010254 transcriptional repressor CodY; Validated; Region: PRK04158 288681010255 CodY GAF-like domain; Region: CodY; pfam06018 288681010256 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 288681010257 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 288681010258 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681010259 Walker A motif; other site 288681010260 ATP binding site [chemical binding]; other site 288681010261 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 288681010262 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 288681010263 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 288681010264 active site 288681010265 HslU subunit interaction site [polypeptide binding]; other site 288681010266 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 288681010267 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 288681010268 active site 288681010269 Int/Topo IB signature motif; other site 288681010270 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 288681010271 Glucose inhibited division protein A; Region: GIDA; pfam01134 288681010272 DNA topoisomerase I; Validated; Region: PRK05582 288681010273 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 288681010274 active site 288681010275 interdomain interaction site; other site 288681010276 putative metal-binding site [ion binding]; other site 288681010277 nucleotide binding site [chemical binding]; other site 288681010278 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 288681010279 domain I; other site 288681010280 DNA binding groove [nucleotide binding] 288681010281 phosphate binding site [ion binding]; other site 288681010282 domain II; other site 288681010283 domain III; other site 288681010284 nucleotide binding site [chemical binding]; other site 288681010285 catalytic site [active] 288681010286 domain IV; other site 288681010287 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 288681010288 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 288681010289 DNA protecting protein DprA; Region: dprA; TIGR00732 288681010290 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 288681010291 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 288681010292 CoA binding domain; Region: CoA_binding; smart00881 288681010293 CoA-ligase; Region: Ligase_CoA; pfam00549 288681010294 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 288681010295 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 288681010296 CoA-ligase; Region: Ligase_CoA; pfam00549 288681010297 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 288681010298 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681010299 active site 288681010300 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 288681010301 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 288681010302 GTP/Mg2+ binding site [chemical binding]; other site 288681010303 G4 box; other site 288681010304 G5 box; other site 288681010305 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 288681010306 G1 box; other site 288681010307 G1 box; other site 288681010308 GTP/Mg2+ binding site [chemical binding]; other site 288681010309 Switch I region; other site 288681010310 G2 box; other site 288681010311 G2 box; other site 288681010312 G3 box; other site 288681010313 G3 box; other site 288681010314 Switch II region; other site 288681010315 Switch II region; other site 288681010316 G4 box; other site 288681010317 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681010318 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681010319 Catalytic site [active] 288681010320 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 288681010321 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 288681010322 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 288681010323 RimM N-terminal domain; Region: RimM; pfam01782 288681010324 PRC-barrel domain; Region: PRC; pfam05239 288681010325 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 288681010326 G-X-X-G motif; other site 288681010327 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 288681010328 signal recognition particle protein; Provisional; Region: PRK10867 288681010329 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 288681010330 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 288681010331 P loop; other site 288681010332 GTP binding site [chemical binding]; other site 288681010333 Signal peptide binding domain; Region: SRP_SPB; pfam02978 288681010334 putative DNA-binding protein; Validated; Region: PRK00118 288681010335 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 288681010336 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 288681010337 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 288681010338 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 288681010339 P loop; other site 288681010340 GTP binding site [chemical binding]; other site 288681010341 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 288681010342 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 288681010343 Walker A/P-loop; other site 288681010344 ATP binding site [chemical binding]; other site 288681010345 Q-loop/lid; other site 288681010346 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 288681010347 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 288681010348 ABC transporter signature motif; other site 288681010349 Walker B; other site 288681010350 D-loop; other site 288681010351 H-loop/switch region; other site 288681010352 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 288681010353 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 288681010354 dimerization interface [polypeptide binding]; other site 288681010355 active site 288681010356 metal binding site [ion binding]; metal-binding site 288681010357 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 288681010358 dsRNA binding site [nucleotide binding]; other site 288681010359 acyl carrier protein; Provisional; Region: acpP; PRK00982 288681010360 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 288681010361 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 288681010362 NAD(P) binding site [chemical binding]; other site 288681010363 homotetramer interface [polypeptide binding]; other site 288681010364 homodimer interface [polypeptide binding]; other site 288681010365 active site 288681010366 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 288681010367 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 288681010368 putative phosphate acyltransferase; Provisional; Region: PRK05331 288681010369 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 288681010370 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 288681010371 active site 2 [active] 288681010372 active site 1 [active] 288681010373 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 288681010374 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 288681010375 generic binding surface II; other site 288681010376 ssDNA binding site; other site 288681010377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681010378 ATP binding site [chemical binding]; other site 288681010379 putative Mg++ binding site [ion binding]; other site 288681010380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681010381 nucleotide binding region [chemical binding]; other site 288681010382 ATP-binding site [chemical binding]; other site 288681010383 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 288681010384 DAK2 domain; Region: Dak2; pfam02734 288681010385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 288681010386 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 288681010387 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 288681010388 Thiamine pyrophosphokinase; Region: TPK; cd07995 288681010389 active site 288681010390 dimerization interface [polypeptide binding]; other site 288681010391 thiamine binding site [chemical binding]; other site 288681010392 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 288681010393 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 288681010394 substrate binding site [chemical binding]; other site 288681010395 hexamer interface [polypeptide binding]; other site 288681010396 metal binding site [ion binding]; metal-binding site 288681010397 GTPase RsgA; Reviewed; Region: PRK00098 288681010398 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 288681010399 RNA binding site [nucleotide binding]; other site 288681010400 homodimer interface [polypeptide binding]; other site 288681010401 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 288681010402 GTPase/Zn-binding domain interface [polypeptide binding]; other site 288681010403 GTP/Mg2+ binding site [chemical binding]; other site 288681010404 G4 box; other site 288681010405 G5 box; other site 288681010406 G1 box; other site 288681010407 Switch I region; other site 288681010408 G2 box; other site 288681010409 G3 box; other site 288681010410 Switch II region; other site 288681010411 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 288681010412 Catalytic domain of Protein Kinases; Region: PKc; cd00180 288681010413 active site 288681010414 ATP binding site [chemical binding]; other site 288681010415 substrate binding site [chemical binding]; other site 288681010416 activation loop (A-loop); other site 288681010417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 288681010418 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288681010419 PASTA domain; Region: PASTA; pfam03793 288681010420 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 288681010421 Protein phosphatase 2C; Region: PP2C; pfam00481 288681010422 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 288681010423 active site 288681010424 23S rRNA m2A2503 methyltransferase; Region: TIGR00048 288681010425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681010426 FeS/SAM binding site; other site 288681010427 16S rRNA methyltransferase B; Provisional; Region: PRK14902 288681010428 NusB family; Region: NusB; pfam01029 288681010429 putative RNA binding site [nucleotide binding]; other site 288681010430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681010431 S-adenosylmethionine binding site [chemical binding]; other site 288681010432 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 288681010433 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 288681010434 putative active site [active] 288681010435 substrate binding site [chemical binding]; other site 288681010436 putative cosubstrate binding site; other site 288681010437 catalytic site [active] 288681010438 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 288681010439 substrate binding site [chemical binding]; other site 288681010440 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288681010441 active site 288681010442 catalytic residues [active] 288681010443 metal binding site [ion binding]; metal-binding site 288681010444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681010445 primosomal protein N' Region: priA; TIGR00595 288681010446 ATP binding site [chemical binding]; other site 288681010447 putative Mg++ binding site [ion binding]; other site 288681010448 helicase superfamily c-terminal domain; Region: HELICc; smart00490 288681010449 nucleotide binding region [chemical binding]; other site 288681010450 ATP-binding site [chemical binding]; other site 288681010451 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 288681010452 Flavoprotein; Region: Flavoprotein; pfam02441 288681010453 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 288681010454 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 288681010455 Guanylate kinase; Region: Guanylate_kin; pfam00625 288681010456 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 288681010457 catalytic site [active] 288681010458 G-X2-G-X-G-K; other site 288681010459 hypothetical protein; Provisional; Region: PRK04323 288681010460 hypothetical protein; Provisional; Region: PRK11820 288681010461 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 288681010462 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 288681010463 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 288681010464 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 288681010465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 288681010466 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 288681010467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010468 motif II; other site 288681010469 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 288681010470 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 288681010471 Domain of unknown function (DUF814); Region: DUF814; pfam05670 288681010472 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288681010473 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 288681010474 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 288681010475 active site 288681010476 Protein of unknown function (DUF664); Region: DUF664; pfam04978 288681010477 DinB superfamily; Region: DinB_2; pfam12867 288681010478 YoqO-like protein; Region: YoqO; pfam14037 288681010479 YoqO-like protein; Region: YoqO; pfam14037 288681010480 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 288681010481 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 288681010482 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681010483 active site 288681010484 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 288681010485 active site 288681010486 dimer interface [polypeptide binding]; other site 288681010487 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 288681010488 heterodimer interface [polypeptide binding]; other site 288681010489 active site 288681010490 FMN binding site [chemical binding]; other site 288681010491 homodimer interface [polypeptide binding]; other site 288681010492 substrate binding site [chemical binding]; other site 288681010493 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 288681010494 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 288681010495 FAD binding pocket [chemical binding]; other site 288681010496 FAD binding motif [chemical binding]; other site 288681010497 phosphate binding motif [ion binding]; other site 288681010498 beta-alpha-beta structure motif; other site 288681010499 NAD binding pocket [chemical binding]; other site 288681010500 Iron coordination center [ion binding]; other site 288681010501 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 288681010502 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010503 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 288681010504 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 288681010505 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010506 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288681010507 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 288681010508 IMP binding site; other site 288681010509 dimer interface [polypeptide binding]; other site 288681010510 interdomain contacts; other site 288681010511 partial ornithine binding site; other site 288681010512 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 288681010513 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 288681010514 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 288681010515 catalytic site [active] 288681010516 subunit interface [polypeptide binding]; other site 288681010517 dihydroorotase; Validated; Region: pyrC; PRK09357 288681010518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 288681010519 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 288681010520 active site 288681010521 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 288681010522 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 288681010523 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 288681010524 uracil transporter; Provisional; Region: PRK10720 288681010525 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681010526 active site 288681010527 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 288681010528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681010529 RNA binding surface [nucleotide binding]; other site 288681010530 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 288681010531 active site 288681010532 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 288681010533 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 288681010534 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 288681010535 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288681010536 active site 288681010537 HIGH motif; other site 288681010538 nucleotide binding site [chemical binding]; other site 288681010539 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 288681010540 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 288681010541 active site 288681010542 KMSKS motif; other site 288681010543 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 288681010544 tRNA binding surface [nucleotide binding]; other site 288681010545 anticodon binding site; other site 288681010546 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288681010547 DivIVA protein; Region: DivIVA; pfam05103 288681010548 DivIVA domain; Region: DivI1A_domain; TIGR03544 288681010549 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 288681010550 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 288681010551 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681010552 RNA binding surface [nucleotide binding]; other site 288681010553 YGGT family; Region: YGGT; pfam02325 288681010554 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 288681010555 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 288681010556 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 288681010557 catalytic residue [active] 288681010558 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 288681010559 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 288681010560 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 288681010561 sporulation sigma factor SigG; Reviewed; Region: PRK08215 288681010562 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681010563 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681010564 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681010565 DNA binding residues [nucleotide binding] 288681010566 sporulation sigma factor SigE; Reviewed; Region: PRK08301 288681010567 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681010568 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681010569 DNA binding residues [nucleotide binding] 288681010570 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 288681010571 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 288681010572 cell division protein FtsZ; Validated; Region: PRK09330 288681010573 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 288681010574 nucleotide binding site [chemical binding]; other site 288681010575 SulA interaction site; other site 288681010576 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 288681010577 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681010578 nucleotide binding site [chemical binding]; other site 288681010579 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 288681010580 Cell division protein FtsA; Region: FtsA; pfam14450 288681010581 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 288681010582 Cell division protein FtsQ; Region: FtsQ; pfam03799 288681010583 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 288681010584 FAD binding domain; Region: FAD_binding_4; pfam01565 288681010585 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 288681010586 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 288681010587 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 288681010588 active site 288681010589 homodimer interface [polypeptide binding]; other site 288681010590 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 288681010591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010592 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 288681010593 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681010594 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681010595 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 288681010596 Mg++ binding site [ion binding]; other site 288681010597 putative catalytic motif [active] 288681010598 putative substrate binding site [chemical binding]; other site 288681010599 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 288681010600 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681010601 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681010602 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681010603 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 288681010604 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681010605 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681010606 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 288681010607 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681010608 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681010609 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681010610 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 288681010611 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 288681010612 Cell division protein FtsL; Region: FtsL; cl11433 288681010613 MraW methylase family; Region: Methyltransf_5; pfam01795 288681010614 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 288681010615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 288681010616 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 288681010617 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 288681010618 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 288681010619 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 288681010620 hypothetical protein; Provisional; Region: PRK13688 288681010621 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681010622 Coenzyme A binding pocket [chemical binding]; other site 288681010623 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 288681010624 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 288681010625 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 288681010626 hypothetical protein; Provisional; Region: PRK13670 288681010627 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 288681010628 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 288681010629 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 288681010630 protein binding site [polypeptide binding]; other site 288681010631 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 288681010632 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 288681010633 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 288681010634 active site 288681010635 nucleophile elbow; other site 288681010636 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 288681010637 Nucleoside recognition; Region: Gate; pfam07670 288681010638 Nucleoside recognition; Region: Gate; pfam07670 288681010639 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 288681010640 active site 288681010641 (T/H)XGH motif; other site 288681010642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681010643 S-adenosylmethionine binding site [chemical binding]; other site 288681010644 hypothetical protein; Provisional; Region: PRK02886 288681010645 Protein of unknown function (DUF964); Region: DUF964; pfam06133 288681010646 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681010647 catalytic core [active] 288681010648 YlbE-like protein; Region: YlbE; pfam14003 288681010649 Putative coat protein; Region: YlbD_coat; pfam14071 288681010650 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 288681010651 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 288681010652 YugN-like family; Region: YugN; pfam08868 288681010653 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 288681010654 multimer interface [polypeptide binding]; other site 288681010655 active site 288681010656 catalytic triad [active] 288681010657 dimer interface [polypeptide binding]; other site 288681010658 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 288681010659 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 288681010660 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 288681010661 Subunit I/III interface [polypeptide binding]; other site 288681010662 Subunit III/IV interface [polypeptide binding]; other site 288681010663 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 288681010664 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 288681010665 D-pathway; other site 288681010666 Putative ubiquinol binding site [chemical binding]; other site 288681010667 Low-spin heme (heme b) binding site [chemical binding]; other site 288681010668 Putative water exit pathway; other site 288681010669 Binuclear center (heme o3/CuB) [ion binding]; other site 288681010670 K-pathway; other site 288681010671 Putative proton exit pathway; other site 288681010672 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 288681010673 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 288681010674 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 288681010675 Cytochrome c; Region: Cytochrom_C; pfam00034 288681010676 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 288681010677 putative active site [active] 288681010678 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 288681010679 pyruvate carboxylase; Reviewed; Region: PRK12999 288681010680 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681010681 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 288681010682 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 288681010683 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 288681010684 active site 288681010685 catalytic residues [active] 288681010686 metal binding site [ion binding]; metal-binding site 288681010687 homodimer binding site [polypeptide binding]; other site 288681010688 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288681010689 carboxyltransferase (CT) interaction site; other site 288681010690 biotinylation site [posttranslational modification]; other site 288681010691 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 288681010692 hypothetical protein; Provisional; Region: PRK13666 288681010693 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 288681010694 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 288681010695 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 288681010696 putative active site [active] 288681010697 PhoH-like protein; Region: PhoH; pfam02562 288681010698 hypothetical protein; Provisional; Region: PRK06733 288681010699 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 288681010700 YlaH-like protein; Region: YlaH; pfam14036 288681010701 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 288681010702 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 288681010703 G1 box; other site 288681010704 putative GEF interaction site [polypeptide binding]; other site 288681010705 GTP/Mg2+ binding site [chemical binding]; other site 288681010706 Switch I region; other site 288681010707 G2 box; other site 288681010708 G3 box; other site 288681010709 Switch II region; other site 288681010710 G4 box; other site 288681010711 G5 box; other site 288681010712 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 288681010713 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 288681010714 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 288681010715 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 288681010716 active site 288681010717 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 288681010718 hypothetical protein; Provisional; Region: PRK04387 288681010719 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 288681010720 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 288681010721 homodimer interface [polypeptide binding]; other site 288681010722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010723 catalytic residue [active] 288681010724 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 288681010725 transglutaminase; Provisional; Region: tgl; PRK03187 288681010726 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 288681010727 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 288681010728 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 288681010729 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 288681010730 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681010731 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 288681010732 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288681010733 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681010734 E3 interaction surface; other site 288681010735 lipoyl attachment site [posttranslational modification]; other site 288681010736 e3 binding domain; Region: E3_binding; pfam02817 288681010737 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288681010738 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288681010739 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288681010740 alpha subunit interface [polypeptide binding]; other site 288681010741 TPP binding site [chemical binding]; other site 288681010742 heterodimer interface [polypeptide binding]; other site 288681010743 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681010744 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 288681010745 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288681010746 TPP-binding site [chemical binding]; other site 288681010747 heterodimer interface [polypeptide binding]; other site 288681010748 tetramer interface [polypeptide binding]; other site 288681010749 phosphorylation loop region [posttranslational modification] 288681010750 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 288681010751 active site 288681010752 catalytic residues [active] 288681010753 metal binding site [ion binding]; metal-binding site 288681010754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010755 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681010756 active site 288681010757 motif I; other site 288681010758 motif II; other site 288681010759 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010760 hypothetical protein; Provisional; Region: PRK13667 288681010761 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 288681010762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681010763 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 288681010764 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681010765 TrkA-N domain; Region: TrkA_N; pfam02254 288681010766 TrkA-C domain; Region: TrkA_C; pfam02080 288681010767 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 288681010768 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 288681010769 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 288681010770 metal binding site [ion binding]; metal-binding site 288681010771 putative dimer interface [polypeptide binding]; other site 288681010772 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 288681010773 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 288681010774 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 288681010775 trimer interface [polypeptide binding]; other site 288681010776 active site 288681010777 substrate binding site [chemical binding]; other site 288681010778 CoA binding site [chemical binding]; other site 288681010779 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681010780 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681010781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681010782 dimerization interface [polypeptide binding]; other site 288681010783 FOG: CBS domain [General function prediction only]; Region: COG0517 288681010784 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 288681010785 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 288681010786 Protein of unknown function (DUF458); Region: DUF458; pfam04308 288681010787 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 288681010788 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 288681010789 catalytic residues [active] 288681010790 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 288681010791 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681010792 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 288681010793 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 288681010794 short chain dehydrogenase; Provisional; Region: PRK07677 288681010795 NAD(P) binding site [chemical binding]; other site 288681010796 substrate binding site [chemical binding]; other site 288681010797 homotetramer interface [polypeptide binding]; other site 288681010798 active site 288681010799 homodimer interface [polypeptide binding]; other site 288681010800 phosphodiesterase YaeI; Provisional; Region: PRK11340 288681010801 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681010802 putative active site [active] 288681010803 putative metal binding site [ion binding]; other site 288681010804 polyphosphate kinase; Provisional; Region: PRK05443 288681010805 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 288681010806 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 288681010807 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 288681010808 putative domain interface [polypeptide binding]; other site 288681010809 putative active site [active] 288681010810 catalytic site [active] 288681010811 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 288681010812 putative domain interface [polypeptide binding]; other site 288681010813 putative active site [active] 288681010814 catalytic site [active] 288681010815 exopolyphosphatase; Region: exo_poly_only; TIGR03706 288681010816 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681010817 nucleotide binding site [chemical binding]; other site 288681010818 YkyB-like protein; Region: YkyB; pfam14177 288681010819 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 288681010820 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681010821 I-site; other site 288681010822 active site 288681010823 metal binding site [ion binding]; metal-binding site 288681010824 Phage lysis protein, holin; Region: Phage_holin; cl04675 288681010825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681010826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681010827 putative substrate translocation pore; other site 288681010828 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681010829 Transcriptional regulator PadR-like family; Region: PadR; cl17335 288681010830 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 288681010831 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 288681010832 THF binding site; other site 288681010833 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 288681010834 substrate binding site [chemical binding]; other site 288681010835 THF binding site; other site 288681010836 zinc-binding site [ion binding]; other site 288681010837 Competence protein J (ComJ); Region: ComJ; pfam11033 288681010838 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 288681010839 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 288681010840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681010841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681010842 dimer interface [polypeptide binding]; other site 288681010843 phosphorylation site [posttranslational modification] 288681010844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681010845 ATP binding site [chemical binding]; other site 288681010846 Mg2+ binding site [ion binding]; other site 288681010847 G-X-G motif; other site 288681010848 aminotransferase A; Validated; Region: PRK07683 288681010849 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681010850 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010851 homodimer interface [polypeptide binding]; other site 288681010852 catalytic residue [active] 288681010853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681010854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681010855 DNA binding site [nucleotide binding] 288681010856 domain linker motif; other site 288681010857 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 288681010858 putative dimerization interface [polypeptide binding]; other site 288681010859 putative ligand binding site [chemical binding]; other site 288681010860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 288681010861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681010862 dimer interface [polypeptide binding]; other site 288681010863 conserved gate region; other site 288681010864 putative PBP binding loops; other site 288681010865 ABC-ATPase subunit interface; other site 288681010866 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 288681010867 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681010868 dimer interface [polypeptide binding]; other site 288681010869 conserved gate region; other site 288681010870 putative PBP binding loops; other site 288681010871 ABC-ATPase subunit interface; other site 288681010872 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 288681010873 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 288681010874 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 288681010875 homodimer interface [polypeptide binding]; other site 288681010876 maltodextrin glucosidase; Provisional; Region: PRK10785 288681010877 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 288681010878 active site 288681010879 homodimer interface [polypeptide binding]; other site 288681010880 catalytic site [active] 288681010881 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 288681010882 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 288681010883 Ca binding site [ion binding]; other site 288681010884 active site 288681010885 catalytic site [active] 288681010886 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 288681010887 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 288681010888 Walker A/P-loop; other site 288681010889 ATP binding site [chemical binding]; other site 288681010890 Q-loop/lid; other site 288681010891 ABC transporter signature motif; other site 288681010892 Walker B; other site 288681010893 D-loop; other site 288681010894 H-loop/switch region; other site 288681010895 TOBE domain; Region: TOBE_2; pfam08402 288681010896 hypothetical protein; Provisional; Region: PRK06720 288681010897 NAD(P) binding site [chemical binding]; other site 288681010898 RDD family; Region: RDD; pfam06271 288681010899 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 288681010900 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 288681010901 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 288681010902 Predicted ATPase [General function prediction only]; Region: COG3910 288681010903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681010904 Walker A/P-loop; other site 288681010905 ATP binding site [chemical binding]; other site 288681010906 Q-loop/lid; other site 288681010907 ABC transporter signature motif; other site 288681010908 Walker B; other site 288681010909 D-loop; other site 288681010910 H-loop/switch region; other site 288681010911 putative acyltransferase; Provisional; Region: PRK05790 288681010912 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681010913 dimer interface [polypeptide binding]; other site 288681010914 active site 288681010915 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681010916 nudix motif; other site 288681010917 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 288681010918 hypothetical protein; Validated; Region: PRK07668 288681010919 hypothetical protein; Validated; Region: PRK07668 288681010920 hypothetical protein; Validated; Region: PRK07668 288681010921 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681010922 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681010923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681010924 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 288681010925 NAD(P) binding site [chemical binding]; other site 288681010926 active site 288681010927 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 288681010928 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 288681010929 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 288681010930 Phosphotransferase enzyme family; Region: APH; pfam01636 288681010931 Predicted amidohydrolase [General function prediction only]; Region: COG0388 288681010932 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 288681010933 putative active site [active] 288681010934 catalytic triad [active] 288681010935 putative dimer interface [polypeptide binding]; other site 288681010936 transaminase; Reviewed; Region: PRK08068 288681010937 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681010938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681010939 homodimer interface [polypeptide binding]; other site 288681010940 catalytic residue [active] 288681010941 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 288681010942 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 288681010943 dimer interface [polypeptide binding]; other site 288681010944 active site 288681010945 catalytic residue [active] 288681010946 metal binding site [ion binding]; metal-binding site 288681010947 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 288681010948 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 288681010949 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 288681010950 intersubunit interface [polypeptide binding]; other site 288681010951 active site 288681010952 Zn2+ binding site [ion binding]; other site 288681010953 ARD/ARD' family; Region: ARD; pfam03079 288681010954 Cupin domain; Region: Cupin_2; pfam07883 288681010955 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 288681010956 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 288681010957 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 288681010958 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681010959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681010960 metal binding site [ion binding]; metal-binding site 288681010961 active site 288681010962 I-site; other site 288681010963 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 288681010964 dimer interface [polypeptide binding]; other site 288681010965 FMN binding site [chemical binding]; other site 288681010966 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 288681010967 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 288681010968 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 288681010969 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 288681010970 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 288681010971 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 288681010972 dimerization domain swap beta strand [polypeptide binding]; other site 288681010973 regulatory protein interface [polypeptide binding]; other site 288681010974 active site 288681010975 regulatory phosphorylation site [posttranslational modification]; other site 288681010976 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 288681010977 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 288681010978 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 288681010979 active site turn [active] 288681010980 phosphorylation site [posttranslational modification] 288681010981 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 288681010982 HPr interaction site; other site 288681010983 glycerol kinase (GK) interaction site [polypeptide binding]; other site 288681010984 active site 288681010985 phosphorylation site [posttranslational modification] 288681010986 transcriptional antiterminator BglG; Provisional; Region: PRK09772 288681010987 CAT RNA binding domain; Region: CAT_RBD; smart01061 288681010988 PRD domain; Region: PRD; pfam00874 288681010989 PRD domain; Region: PRD; pfam00874 288681010990 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681010991 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010992 active site 288681010993 motif I; other site 288681010994 motif II; other site 288681010995 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681010996 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681010997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681010998 DNA-binding site [nucleotide binding]; DNA binding site 288681010999 UTRA domain; Region: UTRA; pfam07702 288681011000 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 288681011001 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 288681011002 active site 288681011003 trimer interface [polypeptide binding]; other site 288681011004 allosteric site; other site 288681011005 active site lid [active] 288681011006 hexamer (dimer of trimers) interface [polypeptide binding]; other site 288681011007 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 288681011008 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 288681011009 active site 288681011010 dimer interface [polypeptide binding]; other site 288681011011 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 288681011012 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681011013 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 288681011014 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 288681011015 Domain of unknown function (DUF309); Region: DUF309; pfam03745 288681011016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681011017 Coenzyme A binding pocket [chemical binding]; other site 288681011018 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 288681011019 active site 288681011020 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 288681011021 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681011022 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 288681011023 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288681011024 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681011025 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 288681011026 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 288681011027 stage V sporulation protein AD; Validated; Region: PRK08304 288681011028 stage V sporulation protein AD; Provisional; Region: PRK12404 288681011029 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 288681011030 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 288681011031 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 288681011032 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 288681011033 Na2 binding site [ion binding]; other site 288681011034 putative substrate binding site 1 [chemical binding]; other site 288681011035 Na binding site 1 [ion binding]; other site 288681011036 putative substrate binding site 2 [chemical binding]; other site 288681011037 sporulation sigma factor SigF; Validated; Region: PRK05572 288681011038 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681011039 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681011040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681011041 DNA binding residues [nucleotide binding] 288681011042 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681011043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681011044 ATP binding site [chemical binding]; other site 288681011045 Mg2+ binding site [ion binding]; other site 288681011046 G-X-G motif; other site 288681011047 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 288681011048 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 288681011049 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681011050 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 288681011051 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681011052 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681011053 DNA-binding site [nucleotide binding]; DNA binding site 288681011054 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681011055 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681011056 Walker A/P-loop; other site 288681011057 ATP binding site [chemical binding]; other site 288681011058 Q-loop/lid; other site 288681011059 ABC transporter signature motif; other site 288681011060 Walker B; other site 288681011061 D-loop; other site 288681011062 H-loop/switch region; other site 288681011063 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681011064 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 288681011065 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681011066 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 288681011067 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681011068 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681011069 dimerization interface [polypeptide binding]; other site 288681011070 putative Zn2+ binding site [ion binding]; other site 288681011071 putative DNA binding site [nucleotide binding]; other site 288681011072 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 288681011073 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 288681011074 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 288681011075 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 288681011076 oligomer interface [polypeptide binding]; other site 288681011077 metal binding site [ion binding]; metal-binding site 288681011078 metal binding site [ion binding]; metal-binding site 288681011079 putative Cl binding site [ion binding]; other site 288681011080 aspartate ring; other site 288681011081 basic sphincter; other site 288681011082 hydrophobic gate; other site 288681011083 periplasmic entrance; other site 288681011084 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 288681011085 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 288681011086 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 288681011087 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 288681011088 purine nucleoside phosphorylase; Provisional; Region: PRK08202 288681011089 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 288681011090 phosphopentomutase; Provisional; Region: PRK05362 288681011091 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 288681011092 YtkA-like; Region: YtkA; pfam13115 288681011093 YtkA-like; Region: YtkA; pfam13115 288681011094 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 288681011095 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 288681011096 active site 288681011097 Int/Topo IB signature motif; other site 288681011098 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 288681011099 ferric uptake regulator; Provisional; Region: fur; PRK09462 288681011100 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288681011101 metal binding site 2 [ion binding]; metal-binding site 288681011102 putative DNA binding helix; other site 288681011103 metal binding site 1 [ion binding]; metal-binding site 288681011104 dimer interface [polypeptide binding]; other site 288681011105 structural Zn2+ binding site [ion binding]; other site 288681011106 stage II sporulation protein M; Region: spo_II_M; TIGR02831 288681011107 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681011108 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681011109 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 288681011110 dimer interface [polypeptide binding]; other site 288681011111 ADP-ribose binding site [chemical binding]; other site 288681011112 active site 288681011113 nudix motif; other site 288681011114 metal binding site [ion binding]; metal-binding site 288681011115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681011116 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681011117 active site 288681011118 catalytic tetrad [active] 288681011119 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681011120 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681011121 active site 288681011122 catalytic tetrad [active] 288681011123 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 288681011124 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 288681011125 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681011126 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 288681011127 putative active site [active] 288681011128 putative metal binding site [ion binding]; other site 288681011129 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681011130 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 288681011131 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 288681011132 Predicted permease [General function prediction only]; Region: COG2056 288681011133 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 288681011134 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 288681011135 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681011136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681011137 DNA binding site [nucleotide binding] 288681011138 domain linker motif; other site 288681011139 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 288681011140 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681011141 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681011142 Coenzyme A binding pocket [chemical binding]; other site 288681011143 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 288681011144 Putative lysophospholipase; Region: Hydrolase_4; cl19140 288681011145 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 288681011146 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 288681011147 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 288681011148 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288681011149 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288681011150 catalytic motif [active] 288681011151 Zn binding site [ion binding]; other site 288681011152 RibD C-terminal domain; Region: RibD_C; cl17279 288681011153 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 288681011154 Lumazine binding domain; Region: Lum_binding; pfam00677 288681011155 Lumazine binding domain; Region: Lum_binding; pfam00677 288681011156 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 288681011157 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 288681011158 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288681011159 dimerization interface [polypeptide binding]; other site 288681011160 active site 288681011161 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 288681011162 homopentamer interface [polypeptide binding]; other site 288681011163 active site 288681011164 biotin synthase; Validated; Region: PRK06256 288681011165 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681011166 FeS/SAM binding site; other site 288681011167 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 288681011168 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 288681011169 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011170 S-adenosylmethionine binding site [chemical binding]; other site 288681011171 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681011172 TAP-like protein; Region: Abhydrolase_4; pfam08386 288681011173 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 288681011174 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 288681011175 substrate-cofactor binding pocket; other site 288681011176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011177 catalytic residue [active] 288681011178 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 288681011179 AAA domain; Region: AAA_26; pfam13500 288681011180 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 288681011181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681011182 inhibitor-cofactor binding pocket; inhibition site 288681011183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011184 catalytic residue [active] 288681011185 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 288681011186 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 288681011187 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 288681011188 active site 288681011189 metal binding site [ion binding]; metal-binding site 288681011190 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681011191 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 288681011192 active site 288681011193 catalytic triad [active] 288681011194 oxyanion hole [active] 288681011195 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681011196 dimerization interface [polypeptide binding]; other site 288681011197 putative DNA binding site [nucleotide binding]; other site 288681011198 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681011199 putative Zn2+ binding site [ion binding]; other site 288681011200 ornithine carbamoyltransferase; Provisional; Region: PRK00779 288681011201 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 288681011202 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 288681011203 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 288681011204 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681011205 inhibitor-cofactor binding pocket; inhibition site 288681011206 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011207 catalytic residue [active] 288681011208 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 288681011209 nucleotide binding site [chemical binding]; other site 288681011210 N-acetyl-L-glutamate binding site [chemical binding]; other site 288681011211 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 288681011212 heterotetramer interface [polypeptide binding]; other site 288681011213 active site pocket [active] 288681011214 cleavage site 288681011215 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 288681011216 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 288681011217 YqzH-like protein; Region: YqzH; pfam14164 288681011218 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 288681011219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681011220 NAD(P) binding site [chemical binding]; other site 288681011221 active site 288681011222 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681011223 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 288681011224 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 288681011225 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 288681011226 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 288681011227 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 288681011228 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 288681011229 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 288681011230 putative L-serine binding site [chemical binding]; other site 288681011231 ribonuclease Z; Region: RNase_Z; TIGR02651 288681011232 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 288681011233 DNA polymerase IV; Validated; Region: PRK01810 288681011234 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 288681011235 active site 288681011236 DNA binding site [nucleotide binding] 288681011237 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 288681011238 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 288681011239 peptidase T-like protein; Region: PepT-like; TIGR01883 288681011240 metal binding site [ion binding]; metal-binding site 288681011241 putative dimer interface [polypeptide binding]; other site 288681011242 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681011243 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681011244 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 288681011245 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 288681011246 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 288681011247 Predicted membrane protein [Function unknown]; Region: COG4129 288681011248 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 288681011249 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 288681011250 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 288681011251 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 288681011252 Walker A/P-loop; other site 288681011253 ATP binding site [chemical binding]; other site 288681011254 Q-loop/lid; other site 288681011255 ABC transporter signature motif; other site 288681011256 Walker B; other site 288681011257 D-loop; other site 288681011258 H-loop/switch region; other site 288681011259 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 288681011260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011261 dimer interface [polypeptide binding]; other site 288681011262 conserved gate region; other site 288681011263 putative PBP binding loops; other site 288681011264 ABC-ATPase subunit interface; other site 288681011265 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 288681011266 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 288681011267 substrate binding pocket [chemical binding]; other site 288681011268 membrane-bound complex binding site; other site 288681011269 hinge residues; other site 288681011270 Disulphide isomerase; Region: Disulph_isomer; pfam06491 288681011271 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 288681011272 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 288681011273 nudix motif; other site 288681011274 Predicted membrane protein [Function unknown]; Region: COG2323 288681011275 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 288681011276 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 288681011277 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 288681011278 E3 interaction surface; other site 288681011279 lipoyl attachment site [posttranslational modification]; other site 288681011280 e3 binding domain; Region: E3_binding; pfam02817 288681011281 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 288681011282 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 288681011283 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 288681011284 alpha subunit interface [polypeptide binding]; other site 288681011285 TPP binding site [chemical binding]; other site 288681011286 heterodimer interface [polypeptide binding]; other site 288681011287 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681011288 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 288681011289 tetramer interface [polypeptide binding]; other site 288681011290 TPP-binding site [chemical binding]; other site 288681011291 heterodimer interface [polypeptide binding]; other site 288681011292 phosphorylation loop region [posttranslational modification] 288681011293 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 288681011294 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 288681011295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681011296 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 288681011297 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681011298 nucleotide binding site [chemical binding]; other site 288681011299 Acetokinase family; Region: Acetate_kinase; cl17229 288681011300 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 288681011301 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 288681011302 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 288681011303 NAD binding site [chemical binding]; other site 288681011304 Phe binding site; other site 288681011305 phosphate butyryltransferase; Validated; Region: PRK07742 288681011306 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 288681011307 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681011308 putative active site [active] 288681011309 heme pocket [chemical binding]; other site 288681011310 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681011311 putative active site [active] 288681011312 heme pocket [chemical binding]; other site 288681011313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011314 Walker A motif; other site 288681011315 ATP binding site [chemical binding]; other site 288681011316 Walker B motif; other site 288681011317 arginine finger; other site 288681011318 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 288681011319 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 288681011320 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681011321 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 288681011322 active site 288681011323 catalytic site [active] 288681011324 metal binding site [ion binding]; metal-binding site 288681011325 dimer interface [polypeptide binding]; other site 288681011326 conserved hypothetical integral membrane protein; Region: TIGR03766 288681011327 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681011328 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 288681011329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681011330 active site 288681011331 phosphorylation site [posttranslational modification] 288681011332 intermolecular recognition site; other site 288681011333 dimerization interface [polypeptide binding]; other site 288681011334 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 288681011335 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 288681011336 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 288681011337 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 288681011338 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 288681011339 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 288681011340 Walker A/P-loop; other site 288681011341 ATP binding site [chemical binding]; other site 288681011342 Q-loop/lid; other site 288681011343 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 288681011344 ABC transporter signature motif; other site 288681011345 Walker B; other site 288681011346 D-loop; other site 288681011347 H-loop/switch region; other site 288681011348 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 288681011349 arginine repressor; Provisional; Region: PRK04280 288681011350 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 288681011351 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 288681011352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681011353 RNA binding surface [nucleotide binding]; other site 288681011354 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 288681011355 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 288681011356 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 288681011357 TPP-binding site; other site 288681011358 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 288681011359 PYR/PP interface [polypeptide binding]; other site 288681011360 dimer interface [polypeptide binding]; other site 288681011361 TPP binding site [chemical binding]; other site 288681011362 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 288681011363 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 288681011364 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 288681011365 substrate binding pocket [chemical binding]; other site 288681011366 chain length determination region; other site 288681011367 substrate-Mg2+ binding site; other site 288681011368 catalytic residues [active] 288681011369 aspartate-rich region 1; other site 288681011370 active site lid residues [active] 288681011371 aspartate-rich region 2; other site 288681011372 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 288681011373 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 288681011374 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 288681011375 generic binding surface II; other site 288681011376 generic binding surface I; other site 288681011377 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 288681011378 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 288681011379 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 288681011380 homodimer interface [polypeptide binding]; other site 288681011381 NADP binding site [chemical binding]; other site 288681011382 substrate binding site [chemical binding]; other site 288681011383 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 288681011384 putative RNA binding site [nucleotide binding]; other site 288681011385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 288681011386 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 288681011387 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 288681011388 ATP-grasp domain; Region: ATP-grasp_4; cl17255 288681011389 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 288681011390 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 288681011391 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 288681011392 carboxyltransferase (CT) interaction site; other site 288681011393 biotinylation site [posttranslational modification]; other site 288681011394 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 288681011395 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 288681011396 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 288681011397 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 288681011398 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 288681011399 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 288681011400 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 288681011401 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 288681011402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011403 Walker A motif; other site 288681011404 ATP binding site [chemical binding]; other site 288681011405 Walker B motif; other site 288681011406 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 288681011407 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681011408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681011409 elongation factor P; Validated; Region: PRK00529 288681011410 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 288681011411 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 288681011412 RNA binding site [nucleotide binding]; other site 288681011413 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 288681011414 RNA binding site [nucleotide binding]; other site 288681011415 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288681011416 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 288681011417 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 288681011418 active site 288681011419 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 288681011420 trimer interface [polypeptide binding]; other site 288681011421 active site 288681011422 dimer interface [polypeptide binding]; other site 288681011423 Conserved membrane protein YqhR; Region: YqhR; pfam11085 288681011424 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 288681011425 CCC1-related family of proteins; Region: CCC1_like; cl00278 288681011426 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 288681011427 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 288681011428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681011429 motif II; other site 288681011430 manganese transport transcriptional regulator; Provisional; Region: PRK03902 288681011431 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 288681011432 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 288681011433 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 288681011434 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681011435 FeS/SAM binding site; other site 288681011436 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681011437 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681011438 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288681011439 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681011440 active site residue [active] 288681011441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681011442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681011443 DNA binding site [nucleotide binding] 288681011444 domain linker motif; other site 288681011445 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681011446 putative dimerization interface [polypeptide binding]; other site 288681011447 putative ligand binding site [chemical binding]; other site 288681011448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681011449 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681011450 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 288681011451 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 288681011452 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 288681011453 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681011454 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681011455 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681011456 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 288681011457 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681011458 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681011459 Walker A/P-loop; other site 288681011460 ATP binding site [chemical binding]; other site 288681011461 Q-loop/lid; other site 288681011462 ABC transporter signature motif; other site 288681011463 Walker B; other site 288681011464 D-loop; other site 288681011465 H-loop/switch region; other site 288681011466 Predicted transcriptional regulators [Transcription]; Region: COG1725 288681011467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681011468 DNA-binding site [nucleotide binding]; DNA binding site 288681011469 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 288681011470 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 288681011471 tetramer interface [polypeptide binding]; other site 288681011472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011473 catalytic residue [active] 288681011474 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 288681011475 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 288681011476 tetramer interface [polypeptide binding]; other site 288681011477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011478 catalytic residue [active] 288681011479 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 288681011480 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 288681011481 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 288681011482 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 288681011483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681011484 ATP binding site [chemical binding]; other site 288681011485 putative Mg++ binding site [ion binding]; other site 288681011486 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 288681011487 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681011488 nucleotide binding region [chemical binding]; other site 288681011489 ATP-binding site [chemical binding]; other site 288681011490 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 288681011491 YqzE-like protein; Region: YqzE; pfam14038 288681011492 shikimate kinase; Reviewed; Region: aroK; PRK00131 288681011493 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 288681011494 ADP binding site [chemical binding]; other site 288681011495 magnesium binding site [ion binding]; other site 288681011496 putative shikimate binding site; other site 288681011497 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 288681011498 ComG operon protein 7; Region: ComGG; pfam14173 288681011499 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 288681011500 Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine; Region: Bromodomain; cl02556 288681011501 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 288681011502 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 288681011503 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 288681011504 Type II/IV secretion system protein; Region: T2SE; pfam00437 288681011505 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 288681011506 Walker A motif; other site 288681011507 ATP binding site [chemical binding]; other site 288681011508 Walker B motif; other site 288681011509 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681011510 putative DNA binding site [nucleotide binding]; other site 288681011511 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 288681011512 putative Zn2+ binding site [ion binding]; other site 288681011513 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 288681011514 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 288681011515 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 288681011516 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 288681011517 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 288681011518 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 288681011519 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 288681011520 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 288681011521 active site 288681011522 homodimer interface [polypeptide binding]; other site 288681011523 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 288681011524 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 288681011525 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 288681011526 substrate binding pocket [chemical binding]; other site 288681011527 dimer interface [polypeptide binding]; other site 288681011528 inhibitor binding site; inhibition site 288681011529 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 288681011530 B12 binding site [chemical binding]; other site 288681011531 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 288681011532 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 288681011533 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 288681011534 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 288681011535 FAD binding site [chemical binding]; other site 288681011536 cystathionine gamma-synthase; Reviewed; Region: PRK08247 288681011537 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681011538 homodimer interface [polypeptide binding]; other site 288681011539 substrate-cofactor binding pocket; other site 288681011540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011541 catalytic residue [active] 288681011542 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681011543 homodimer interface [polypeptide binding]; other site 288681011544 substrate-cofactor binding pocket; other site 288681011545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011546 catalytic residue [active] 288681011547 Isochorismatase family; Region: Isochorismatase; pfam00857 288681011548 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 288681011549 catalytic triad [active] 288681011550 conserved cis-peptide bond; other site 288681011551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681011552 dimerization interface [polypeptide binding]; other site 288681011553 putative DNA binding site [nucleotide binding]; other site 288681011554 putative Zn2+ binding site [ion binding]; other site 288681011555 Uncharacterized conserved protein [Function unknown]; Region: COG1565 288681011556 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 288681011557 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 288681011558 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 288681011559 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 288681011560 nucleotide binding site [chemical binding]; other site 288681011561 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 288681011562 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 288681011563 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 288681011564 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 288681011565 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 288681011566 active site 288681011567 Substrate binding site; other site 288681011568 Mg++ binding site; other site 288681011569 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 288681011570 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 288681011571 active site 288681011572 metal binding site [ion binding]; metal-binding site 288681011573 substrate binding site [chemical binding]; other site 288681011574 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 288681011575 PhoU domain; Region: PhoU; pfam01895 288681011576 PhoU domain; Region: PhoU; pfam01895 288681011577 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 288681011578 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 288681011579 Walker A/P-loop; other site 288681011580 ATP binding site [chemical binding]; other site 288681011581 Q-loop/lid; other site 288681011582 ABC transporter signature motif; other site 288681011583 Walker B; other site 288681011584 D-loop; other site 288681011585 H-loop/switch region; other site 288681011586 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 288681011587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011588 dimer interface [polypeptide binding]; other site 288681011589 conserved gate region; other site 288681011590 putative PBP binding loops; other site 288681011591 ABC-ATPase subunit interface; other site 288681011592 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 288681011593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681011594 dimer interface [polypeptide binding]; other site 288681011595 conserved gate region; other site 288681011596 putative PBP binding loops; other site 288681011597 ABC-ATPase subunit interface; other site 288681011598 PBP superfamily domain; Region: PBP_like_2; cl17296 288681011599 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681011600 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681011601 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681011603 putative substrate translocation pore; other site 288681011604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681011605 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288681011606 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288681011607 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288681011608 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 288681011609 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 288681011610 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 288681011611 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 288681011612 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 288681011613 metal binding site 2 [ion binding]; metal-binding site 288681011614 putative DNA binding helix; other site 288681011615 metal binding site 1 [ion binding]; metal-binding site 288681011616 dimer interface [polypeptide binding]; other site 288681011617 structural Zn2+ binding site [ion binding]; other site 288681011618 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681011619 ABC-ATPase subunit interface; other site 288681011620 dimer interface [polypeptide binding]; other site 288681011621 putative PBP binding regions; other site 288681011622 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 288681011623 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 288681011624 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681011625 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681011626 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681011627 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 288681011628 endonuclease IV; Provisional; Region: PRK01060 288681011629 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 288681011630 AP (apurinic/apyrimidinic) site pocket; other site 288681011631 DNA interaction; other site 288681011632 Metal-binding active site; metal-binding site 288681011633 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681011634 DEAD-like helicases superfamily; Region: DEXDc; smart00487 288681011635 ATP binding site [chemical binding]; other site 288681011636 Mg++ binding site [ion binding]; other site 288681011637 motif III; other site 288681011638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681011639 nucleotide binding region [chemical binding]; other site 288681011640 ATP-binding site [chemical binding]; other site 288681011641 YqfQ-like protein; Region: YqfQ; pfam14181 288681011642 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 288681011643 Fe-S cluster binding site [ion binding]; other site 288681011644 substrate binding site [chemical binding]; other site 288681011645 catalytic site [active] 288681011646 Uncharacterized conserved protein [Function unknown]; Region: COG0327 288681011647 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 288681011648 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 288681011649 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 288681011650 Uncharacterized conserved protein [Function unknown]; Region: COG0327 288681011651 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 288681011652 Family of unknown function (DUF633); Region: DUF633; pfam04816 288681011653 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 288681011654 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 288681011655 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 288681011656 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 288681011657 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 288681011658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681011659 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 288681011660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681011661 DNA binding residues [nucleotide binding] 288681011662 DNA primase; Validated; Region: dnaG; PRK05667 288681011663 CHC2 zinc finger; Region: zf-CHC2; pfam01807 288681011664 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 288681011665 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 288681011666 active site 288681011667 metal binding site [ion binding]; metal-binding site 288681011668 interdomain interaction site; other site 288681011669 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 288681011670 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 288681011671 PEP synthetase regulatory protein; Provisional; Region: PRK05339 288681011672 HTH domain; Region: HTH_11; pfam08279 288681011673 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 288681011674 FOG: CBS domain [General function prediction only]; Region: COG0517 288681011675 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 288681011676 Recombination protein O N terminal; Region: RecO_N; pfam11967 288681011677 Recombination protein O C terminal; Region: RecO_C; pfam02565 288681011678 GTPase Era; Reviewed; Region: era; PRK00089 288681011679 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 288681011680 G1 box; other site 288681011681 GTP/Mg2+ binding site [chemical binding]; other site 288681011682 Switch I region; other site 288681011683 G2 box; other site 288681011684 Switch II region; other site 288681011685 G3 box; other site 288681011686 G4 box; other site 288681011687 G5 box; other site 288681011688 KH domain; Region: KH_2; pfam07650 288681011689 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 288681011690 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 288681011691 active site 288681011692 catalytic motif [active] 288681011693 Zn binding site [ion binding]; other site 288681011694 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 288681011695 metal-binding heat shock protein; Provisional; Region: PRK00016 288681011696 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 288681011697 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 288681011698 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 288681011699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681011700 Zn2+ binding site [ion binding]; other site 288681011701 Mg2+ binding site [ion binding]; other site 288681011702 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 288681011703 PhoH-like protein; Region: PhoH; pfam02562 288681011704 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 288681011705 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 288681011706 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 288681011707 Yqey-like protein; Region: YqeY; pfam09424 288681011708 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 288681011709 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 288681011710 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 288681011711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681011712 FeS/SAM binding site; other site 288681011713 TRAM domain; Region: TRAM; cl01282 288681011714 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 288681011715 RNA methyltransferase, RsmE family; Region: TIGR00046 288681011716 Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264 288681011717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011718 S-adenosylmethionine binding site [chemical binding]; other site 288681011719 chaperone protein DnaJ; Provisional; Region: PRK14280 288681011720 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 288681011721 HSP70 interaction site [polypeptide binding]; other site 288681011722 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 288681011723 substrate binding site [polypeptide binding]; other site 288681011724 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 288681011725 Zn binding sites [ion binding]; other site 288681011726 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 288681011727 dimer interface [polypeptide binding]; other site 288681011728 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 288681011729 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 288681011730 nucleotide binding site [chemical binding]; other site 288681011731 NEF interaction site [polypeptide binding]; other site 288681011732 SBD interface [polypeptide binding]; other site 288681011733 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 288681011734 dimer interface [polypeptide binding]; other site 288681011735 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 288681011736 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 288681011737 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 288681011738 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 288681011739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681011740 FeS/SAM binding site; other site 288681011741 HemN C-terminal domain; Region: HemN_C; pfam06969 288681011742 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681011743 dimerization interface [polypeptide binding]; other site 288681011744 putative DNA binding site [nucleotide binding]; other site 288681011745 putative Zn2+ binding site [ion binding]; other site 288681011746 GTP-binding protein LepA; Provisional; Region: PRK05433 288681011747 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 288681011748 G1 box; other site 288681011749 putative GEF interaction site [polypeptide binding]; other site 288681011750 GTP/Mg2+ binding site [chemical binding]; other site 288681011751 Switch I region; other site 288681011752 G2 box; other site 288681011753 G3 box; other site 288681011754 Switch II region; other site 288681011755 G4 box; other site 288681011756 G5 box; other site 288681011757 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 288681011758 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 288681011759 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 288681011760 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 288681011761 germination protease; Provisional; Region: PRK02858 288681011762 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 288681011763 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 288681011764 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 288681011765 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 288681011766 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 288681011767 Competence protein; Region: Competence; pfam03772 288681011768 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681011769 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 288681011770 catalytic motif [active] 288681011771 Zn binding site [ion binding]; other site 288681011772 SLBB domain; Region: SLBB; pfam10531 288681011773 comEA protein; Region: comE; TIGR01259 288681011774 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 288681011775 late competence protein ComER; Validated; Region: PRK07680 288681011776 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 288681011777 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 288681011778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011779 S-adenosylmethionine binding site [chemical binding]; other site 288681011780 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 288681011781 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681011782 Zn2+ binding site [ion binding]; other site 288681011783 Mg2+ binding site [ion binding]; other site 288681011784 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 288681011785 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 288681011786 active site 288681011787 (T/H)XGH motif; other site 288681011788 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 288681011789 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 288681011790 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 288681011791 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 288681011792 shikimate binding site; other site 288681011793 NAD(P) binding site [chemical binding]; other site 288681011794 GTPase YqeH; Provisional; Region: PRK13796 288681011795 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 288681011796 GTP/Mg2+ binding site [chemical binding]; other site 288681011797 G4 box; other site 288681011798 G5 box; other site 288681011799 G1 box; other site 288681011800 Switch I region; other site 288681011801 G2 box; other site 288681011802 G3 box; other site 288681011803 Switch II region; other site 288681011804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681011805 active site 288681011806 motif I; other site 288681011807 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 288681011808 motif II; other site 288681011809 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 288681011810 sporulation sigma factor SigK; Reviewed; Region: PRK05803 288681011811 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681011812 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681011813 DNA binding residues [nucleotide binding] 288681011814 Integrase core domain; Region: rve; pfam00665 288681011815 Integrase core domain; Region: rve_2; pfam13333 288681011816 HTH-like domain; Region: HTH_21; pfam13276 288681011817 Homeodomain-like domain; Region: HTH_23; cl17451 288681011818 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681011819 Homeodomain-like domain; Region: HTH_23; cl17451 288681011820 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 288681011821 dimer interface [polypeptide binding]; other site 288681011822 FMN binding site [chemical binding]; other site 288681011823 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288681011824 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 288681011825 synthetase active site [active] 288681011826 NTP binding site [chemical binding]; other site 288681011827 metal binding site [ion binding]; metal-binding site 288681011828 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 288681011829 dimer interface [polypeptide binding]; other site 288681011830 Alkaline phosphatase homologues; Region: alkPPc; smart00098 288681011831 active site 288681011832 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681011833 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 288681011834 Coenzyme A binding pocket [chemical binding]; other site 288681011835 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681011836 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681011837 Predicted membrane protein [Function unknown]; Region: COG2259 288681011838 CHAT domain; Region: CHAT; cl17868 288681011839 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 288681011840 catalytic core [active] 288681011841 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 288681011842 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 288681011843 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 288681011844 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681011845 putative active site [active] 288681011846 catalytic triad [active] 288681011847 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 288681011848 putative integrin binding motif; other site 288681011849 PA/protease domain interface [polypeptide binding]; other site 288681011850 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681011851 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 288681011852 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 288681011853 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 288681011854 cofactor binding site; other site 288681011855 metal binding site [ion binding]; metal-binding site 288681011856 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 288681011857 aromatic arch; other site 288681011858 DCoH dimer interaction site [polypeptide binding]; other site 288681011859 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 288681011860 DCoH tetramer interaction site [polypeptide binding]; other site 288681011861 substrate binding site [chemical binding]; other site 288681011862 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 288681011863 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 288681011864 putative metal binding site [ion binding]; other site 288681011865 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 288681011866 active site 288681011867 metal binding site [ion binding]; metal-binding site 288681011868 Predicted membrane protein [Function unknown]; Region: COG2259 288681011869 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681011870 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681011871 non-specific DNA binding site [nucleotide binding]; other site 288681011872 salt bridge; other site 288681011873 sequence-specific DNA binding site [nucleotide binding]; other site 288681011874 Cupin domain; Region: Cupin_2; pfam07883 288681011875 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288681011876 active site 2 [active] 288681011877 active site 1 [active] 288681011878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681011879 Coenzyme A binding pocket [chemical binding]; other site 288681011880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681011881 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681011882 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681011883 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681011884 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681011885 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681011886 Walker A/P-loop; other site 288681011887 ATP binding site [chemical binding]; other site 288681011888 Q-loop/lid; other site 288681011889 ABC transporter signature motif; other site 288681011890 Walker B; other site 288681011891 D-loop; other site 288681011892 H-loop/switch region; other site 288681011893 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681011894 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681011895 ABC-ATPase subunit interface; other site 288681011896 dimer interface [polypeptide binding]; other site 288681011897 putative PBP binding regions; other site 288681011898 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681011899 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288681011900 intersubunit interface [polypeptide binding]; other site 288681011901 YrhC-like protein; Region: YrhC; pfam14143 288681011902 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 288681011903 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 288681011904 putative catalytic cysteine [active] 288681011905 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 288681011906 putative active site [active] 288681011907 metal binding site [ion binding]; metal-binding site 288681011908 cystathionine beta-lyase; Provisional; Region: PRK07671 288681011909 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681011910 homodimer interface [polypeptide binding]; other site 288681011911 substrate-cofactor binding pocket; other site 288681011912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011913 catalytic residue [active] 288681011914 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 288681011915 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 288681011916 dimer interface [polypeptide binding]; other site 288681011917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681011918 catalytic residue [active] 288681011919 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 288681011920 Methyltransferase domain; Region: Methyltransf_23; pfam13489 288681011921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011922 S-adenosylmethionine binding site [chemical binding]; other site 288681011923 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 288681011924 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 288681011925 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 288681011926 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 288681011927 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681011928 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 288681011929 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 288681011930 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 288681011931 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 288681011932 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 288681011933 ATP-binding site [chemical binding]; other site 288681011934 Sugar specificity; other site 288681011935 Pyrimidine base specificity; other site 288681011936 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 288681011937 putative protease; Provisional; Region: PRK15452 288681011938 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 288681011939 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 288681011940 Peptidase family U32; Region: Peptidase_U32; pfam01136 288681011941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681011942 S-adenosylmethionine binding site [chemical binding]; other site 288681011943 YceG-like family; Region: YceG; pfam02618 288681011944 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 288681011945 dimerization interface [polypeptide binding]; other site 288681011946 hypothetical protein; Provisional; Region: PRK13678 288681011947 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 288681011948 hypothetical protein; Provisional; Region: PRK05473 288681011949 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 288681011950 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 288681011951 motif 1; other site 288681011952 active site 288681011953 motif 2; other site 288681011954 motif 3; other site 288681011955 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 288681011956 DHHA1 domain; Region: DHHA1; pfam02272 288681011957 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681011958 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 288681011959 AAA domain; Region: AAA_30; pfam13604 288681011960 Family description; Region: UvrD_C_2; pfam13538 288681011961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681011962 TPR motif; other site 288681011963 binding surface 288681011964 TPR repeat; Region: TPR_11; pfam13414 288681011965 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681011966 binding surface 288681011967 TPR motif; other site 288681011968 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681011969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681011970 binding surface 288681011971 TPR motif; other site 288681011972 TPR repeat; Region: TPR_11; pfam13414 288681011973 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 288681011974 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 288681011975 Ligand Binding Site [chemical binding]; other site 288681011976 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 288681011977 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 288681011978 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681011979 catalytic residue [active] 288681011980 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681011981 Transcriptional regulator; Region: Rrf2; pfam02082 288681011982 recombination factor protein RarA; Reviewed; Region: PRK13342 288681011983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681011984 Walker A motif; other site 288681011985 ATP binding site [chemical binding]; other site 288681011986 Walker B motif; other site 288681011987 arginine finger; other site 288681011988 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 288681011989 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 288681011990 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 288681011991 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 288681011992 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 288681011993 putative ATP binding site [chemical binding]; other site 288681011994 putative substrate interface [chemical binding]; other site 288681011995 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 288681011996 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 288681011997 dimer interface [polypeptide binding]; other site 288681011998 anticodon binding site; other site 288681011999 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 288681012000 homodimer interface [polypeptide binding]; other site 288681012001 motif 1; other site 288681012002 active site 288681012003 motif 2; other site 288681012004 GAD domain; Region: GAD; pfam02938 288681012005 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 288681012006 motif 3; other site 288681012007 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 288681012008 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 288681012009 dimer interface [polypeptide binding]; other site 288681012010 motif 1; other site 288681012011 active site 288681012012 motif 2; other site 288681012013 motif 3; other site 288681012014 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 288681012015 anticodon binding site; other site 288681012016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681012017 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 288681012018 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 288681012019 putative active site [active] 288681012020 dimerization interface [polypeptide binding]; other site 288681012021 putative tRNAtyr binding site [nucleotide binding]; other site 288681012022 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 288681012023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681012024 Zn2+ binding site [ion binding]; other site 288681012025 Mg2+ binding site [ion binding]; other site 288681012026 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 288681012027 synthetase active site [active] 288681012028 NTP binding site [chemical binding]; other site 288681012029 metal binding site [ion binding]; metal-binding site 288681012030 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 288681012031 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 288681012032 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681012033 active site 288681012034 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 288681012035 DHH family; Region: DHH; pfam01368 288681012036 DHHA1 domain; Region: DHHA1; pfam02272 288681012037 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 288681012038 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 288681012039 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 288681012040 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 288681012041 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 288681012042 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 288681012043 Protein export membrane protein; Region: SecD_SecF; pfam02355 288681012044 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 288681012045 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681012046 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 288681012047 Predicted membrane protein [Function unknown]; Region: COG2323 288681012048 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 288681012049 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 288681012050 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 288681012051 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 288681012052 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 288681012053 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 288681012054 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 288681012055 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 288681012056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681012057 Walker A motif; other site 288681012058 ATP binding site [chemical binding]; other site 288681012059 Walker B motif; other site 288681012060 arginine finger; other site 288681012061 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 288681012062 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 288681012063 RuvA N terminal domain; Region: RuvA_N; pfam01330 288681012064 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 288681012065 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 288681012066 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681012067 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 288681012068 putative ligand binding residues [chemical binding]; other site 288681012069 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 288681012070 BofC C-terminal domain; Region: BofC_C; pfam08955 288681012071 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681012072 EamA-like transporter family; Region: EamA; pfam00892 288681012073 EamA-like transporter family; Region: EamA; pfam00892 288681012074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681012075 dimerization interface [polypeptide binding]; other site 288681012076 putative DNA binding site [nucleotide binding]; other site 288681012077 putative Zn2+ binding site [ion binding]; other site 288681012078 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 288681012079 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681012080 quinolinate synthetase; Provisional; Region: PRK09375 288681012081 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 288681012082 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 288681012083 dimerization interface [polypeptide binding]; other site 288681012084 active site 288681012085 L-aspartate oxidase; Provisional; Region: PRK08071 288681012086 L-aspartate oxidase; Provisional; Region: PRK06175 288681012087 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 288681012088 cysteine desulfurase; Provisional; Region: PRK02948 288681012089 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 288681012090 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681012091 catalytic residue [active] 288681012092 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 288681012093 HTH domain; Region: HTH_11; pfam08279 288681012094 3H domain; Region: 3H; pfam02829 288681012095 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 288681012096 MOSC domain; Region: MOSC; pfam03473 288681012097 3-alpha domain; Region: 3-alpha; pfam03475 288681012098 prephenate dehydratase; Provisional; Region: PRK11898 288681012099 Prephenate dehydratase; Region: PDT; pfam00800 288681012100 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 288681012101 putative L-Phe binding site [chemical binding]; other site 288681012102 FtsX-like permease family; Region: FtsX; pfam02687 288681012103 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681012104 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681012105 FtsX-like permease family; Region: FtsX; pfam02687 288681012106 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681012107 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681012108 Walker A/P-loop; other site 288681012109 ATP binding site [chemical binding]; other site 288681012110 Q-loop/lid; other site 288681012111 ABC transporter signature motif; other site 288681012112 Walker B; other site 288681012113 D-loop; other site 288681012114 H-loop/switch region; other site 288681012115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681012116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 288681012117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012118 ATP binding site [chemical binding]; other site 288681012119 Mg2+ binding site [ion binding]; other site 288681012120 G-X-G motif; other site 288681012121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012123 active site 288681012124 phosphorylation site [posttranslational modification] 288681012125 intermolecular recognition site; other site 288681012126 dimerization interface [polypeptide binding]; other site 288681012127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012128 DNA binding site [nucleotide binding] 288681012129 GTPase CgtA; Reviewed; Region: obgE; PRK12297 288681012130 GTP1/OBG; Region: GTP1_OBG; pfam01018 288681012131 Obg GTPase; Region: Obg; cd01898 288681012132 G1 box; other site 288681012133 GTP/Mg2+ binding site [chemical binding]; other site 288681012134 Switch I region; other site 288681012135 G2 box; other site 288681012136 G3 box; other site 288681012137 Switch II region; other site 288681012138 G4 box; other site 288681012139 G5 box; other site 288681012140 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 288681012141 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 288681012142 hypothetical protein; Provisional; Region: PRK14553 288681012143 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 288681012144 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 288681012145 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 288681012146 homodimer interface [polypeptide binding]; other site 288681012147 oligonucleotide binding site [chemical binding]; other site 288681012148 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 288681012149 Peptidase family M50; Region: Peptidase_M50; pfam02163 288681012150 active site 288681012151 putative substrate binding region [chemical binding]; other site 288681012152 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681012153 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681012154 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 288681012155 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 288681012156 P-loop; other site 288681012157 ADP binding residues [chemical binding]; other site 288681012158 Switch I; other site 288681012159 Switch II; other site 288681012160 septum formation inhibitor; Reviewed; Region: minC; PRK00513 288681012161 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 288681012162 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 288681012163 rod shape-determining protein MreC; Provisional; Region: PRK13922 288681012164 rod shape-determining protein MreC; Region: MreC; pfam04085 288681012165 rod shape-determining protein MreB; Provisional; Region: PRK13927 288681012166 MreB and similar proteins; Region: MreB_like; cd10225 288681012167 nucleotide binding site [chemical binding]; other site 288681012168 Mg binding site [ion binding]; other site 288681012169 putative protofilament interaction site [polypeptide binding]; other site 288681012170 RodZ interaction site [polypeptide binding]; other site 288681012171 hypothetical protein; Reviewed; Region: PRK00024 288681012172 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 288681012173 MPN+ (JAMM) motif; other site 288681012174 Zinc-binding site [ion binding]; other site 288681012175 Maf-like protein; Region: Maf; pfam02545 288681012176 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 288681012177 active site 288681012178 dimer interface [polypeptide binding]; other site 288681012179 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 288681012180 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681012181 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681012182 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 288681012183 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 288681012184 active site 288681012185 HIGH motif; other site 288681012186 nucleotide binding site [chemical binding]; other site 288681012187 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 288681012188 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 288681012189 active site 288681012190 KMSKS motif; other site 288681012191 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 288681012192 tRNA binding surface [nucleotide binding]; other site 288681012193 anticodon binding site; other site 288681012194 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 288681012195 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 288681012196 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 288681012197 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681012198 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 288681012199 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 288681012200 inhibitor-cofactor binding pocket; inhibition site 288681012201 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681012202 catalytic residue [active] 288681012203 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 288681012204 dimer interface [polypeptide binding]; other site 288681012205 active site 288681012206 Schiff base residues; other site 288681012207 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 288681012208 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 288681012209 active site 288681012210 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 288681012211 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 288681012212 domain interfaces; other site 288681012213 active site 288681012214 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 288681012215 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 288681012216 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 288681012217 tRNA; other site 288681012218 putative tRNA binding site [nucleotide binding]; other site 288681012219 putative NADP binding site [chemical binding]; other site 288681012220 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 288681012221 Transcriptional regulators [Transcription]; Region: MarR; COG1846 288681012222 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681012223 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 288681012224 Predicted GTPase [General function prediction only]; Region: COG0218 288681012225 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 288681012226 G1 box; other site 288681012227 GTP/Mg2+ binding site [chemical binding]; other site 288681012228 Switch I region; other site 288681012229 G2 box; other site 288681012230 G3 box; other site 288681012231 Switch II region; other site 288681012232 G4 box; other site 288681012233 G5 box; other site 288681012234 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 288681012235 Found in ATP-dependent protease La (LON); Region: LON; smart00464 288681012236 Found in ATP-dependent protease La (LON); Region: LON; smart00464 288681012237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681012238 Walker A motif; other site 288681012239 ATP binding site [chemical binding]; other site 288681012240 Walker B motif; other site 288681012241 arginine finger; other site 288681012242 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 288681012243 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 288681012244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681012245 Walker A motif; other site 288681012246 ATP binding site [chemical binding]; other site 288681012247 Walker B motif; other site 288681012248 arginine finger; other site 288681012249 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 288681012250 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 288681012251 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 288681012252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681012253 Walker A motif; other site 288681012254 ATP binding site [chemical binding]; other site 288681012255 Walker B motif; other site 288681012256 arginine finger; other site 288681012257 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 288681012258 trigger factor; Provisional; Region: tig; PRK01490 288681012259 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 288681012260 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 288681012261 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 288681012262 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 288681012263 pentamer interface [polypeptide binding]; other site 288681012264 dodecaamer interface [polypeptide binding]; other site 288681012265 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 288681012266 HNH endonuclease; Region: HNH_3; pfam13392 288681012267 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681012268 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681012269 catalytic residues [active] 288681012270 catalytic nucleophile [active] 288681012271 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681012272 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681012273 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681012274 Synaptic Site I dimer interface [polypeptide binding]; other site 288681012275 DNA binding site [nucleotide binding] 288681012276 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681012277 DNA-binding interface [nucleotide binding]; DNA binding site 288681012278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681012279 putative DNA binding site [nucleotide binding]; other site 288681012280 putative Zn2+ binding site [ion binding]; other site 288681012281 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 288681012282 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 288681012283 active site 288681012284 catalytic residues [active] 288681012285 DNA binding site [nucleotide binding] 288681012286 Int/Topo IB signature motif; other site 288681012287 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 288681012288 active site 288681012289 metal binding site [ion binding]; metal-binding site 288681012290 homotetramer interface [polypeptide binding]; other site 288681012291 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 288681012292 active site 288681012293 dimerization interface [polypeptide binding]; other site 288681012294 ribonuclease PH; Reviewed; Region: rph; PRK00173 288681012295 Ribonuclease PH; Region: RNase_PH_bact; cd11362 288681012296 hexamer interface [polypeptide binding]; other site 288681012297 active site 288681012298 Sporulation and spore germination; Region: Germane; pfam10646 288681012299 Spore germination protein [General function prediction only]; Region: COG5401 288681012300 Sporulation and spore germination; Region: Germane; pfam10646 288681012301 glutamate racemase; Provisional; Region: PRK00865 288681012302 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681012303 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681012304 DNA binding residues [nucleotide binding] 288681012305 dimerization interface [polypeptide binding]; other site 288681012306 putative uracil/xanthine transporter; Provisional; Region: PRK11412 288681012307 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681012308 EamA-like transporter family; Region: EamA; pfam00892 288681012309 EamA-like transporter family; Region: EamA; pfam00892 288681012310 putative deaminase; Validated; Region: PRK06846 288681012311 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 288681012312 active site 288681012313 putative deaminase; Validated; Region: PRK06846 288681012314 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 288681012315 active site 288681012316 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 288681012317 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 288681012318 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681012319 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 288681012320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681012321 dimer interface [polypeptide binding]; other site 288681012322 conserved gate region; other site 288681012323 ABC-ATPase subunit interface; other site 288681012324 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 288681012325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681012326 dimer interface [polypeptide binding]; other site 288681012327 conserved gate region; other site 288681012328 putative PBP binding loops; other site 288681012329 ABC-ATPase subunit interface; other site 288681012330 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 288681012331 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681012332 Walker A/P-loop; other site 288681012333 ATP binding site [chemical binding]; other site 288681012334 Q-loop/lid; other site 288681012335 ABC transporter signature motif; other site 288681012336 Walker B; other site 288681012337 D-loop; other site 288681012338 H-loop/switch region; other site 288681012339 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681012340 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 288681012341 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 288681012342 Walker A/P-loop; other site 288681012343 ATP binding site [chemical binding]; other site 288681012344 Q-loop/lid; other site 288681012345 ABC transporter signature motif; other site 288681012346 Walker B; other site 288681012347 D-loop; other site 288681012348 H-loop/switch region; other site 288681012349 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 288681012350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 288681012351 Histidine kinase; Region: His_kinase; pfam06580 288681012352 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 288681012353 ATP binding site [chemical binding]; other site 288681012354 Mg2+ binding site [ion binding]; other site 288681012355 G-X-G motif; other site 288681012356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012357 Response regulator receiver domain; Region: Response_reg; pfam00072 288681012358 active site 288681012359 phosphorylation site [posttranslational modification] 288681012360 intermolecular recognition site; other site 288681012361 dimerization interface [polypeptide binding]; other site 288681012362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681012363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681012364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681012365 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 288681012366 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 288681012367 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 288681012368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681012369 non-specific DNA binding site [nucleotide binding]; other site 288681012370 salt bridge; other site 288681012371 sequence-specific DNA binding site [nucleotide binding]; other site 288681012372 Cupin domain; Region: Cupin_2; pfam07883 288681012373 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 288681012374 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 288681012375 amphipathic channel; other site 288681012376 Asn-Pro-Ala signature motifs; other site 288681012377 Predicted transcriptional regulator [Transcription]; Region: COG1959 288681012378 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 288681012379 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 288681012380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681012381 Walker A/P-loop; other site 288681012382 ATP binding site [chemical binding]; other site 288681012383 Q-loop/lid; other site 288681012384 ABC transporter signature motif; other site 288681012385 Walker B; other site 288681012386 D-loop; other site 288681012387 H-loop/switch region; other site 288681012388 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 288681012389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681012390 active site 288681012391 motif I; other site 288681012392 motif II; other site 288681012393 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 288681012394 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 288681012395 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 288681012396 ligand binding site [chemical binding]; other site 288681012397 flagellar motor protein MotA; Validated; Region: PRK08124 288681012398 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 288681012399 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288681012400 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288681012401 active site 288681012402 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 288681012403 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 288681012404 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681012405 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 288681012406 L-aspartate oxidase; Provisional; Region: PRK06175 288681012407 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 288681012408 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 288681012409 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 288681012410 putative Iron-sulfur protein interface [polypeptide binding]; other site 288681012411 proximal heme binding site [chemical binding]; other site 288681012412 distal heme binding site [chemical binding]; other site 288681012413 putative dimer interface [polypeptide binding]; other site 288681012414 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 288681012415 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 288681012416 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 288681012417 GIY-YIG motif/motif A; other site 288681012418 active site 288681012419 catalytic site [active] 288681012420 putative DNA binding site [nucleotide binding]; other site 288681012421 metal binding site [ion binding]; metal-binding site 288681012422 UvrB/uvrC motif; Region: UVR; pfam02151 288681012423 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 288681012424 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681012425 catalytic residues [active] 288681012426 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 288681012427 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 288681012428 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 288681012429 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 288681012430 Ligand binding site [chemical binding]; other site 288681012431 Electron transfer flavoprotein domain; Region: ETF; pfam01012 288681012432 enoyl-CoA hydratase; Provisional; Region: PRK07658 288681012433 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681012434 substrate binding site [chemical binding]; other site 288681012435 oxyanion hole (OAH) forming residues; other site 288681012436 trimer interface [polypeptide binding]; other site 288681012437 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 288681012438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681012439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681012440 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 288681012441 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 288681012442 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 288681012443 acyl-activating enzyme (AAE) consensus motif; other site 288681012444 putative AMP binding site [chemical binding]; other site 288681012445 putative active site [active] 288681012446 putative CoA binding site [chemical binding]; other site 288681012447 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 288681012448 DinB family; Region: DinB; pfam05163 288681012449 DinB superfamily; Region: DinB_2; pfam12867 288681012450 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 288681012451 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681012452 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 288681012453 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681012454 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681012455 Walker A/P-loop; other site 288681012456 ATP binding site [chemical binding]; other site 288681012457 Q-loop/lid; other site 288681012458 ABC transporter signature motif; other site 288681012459 Walker B; other site 288681012460 D-loop; other site 288681012461 H-loop/switch region; other site 288681012462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681012463 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012464 dimer interface [polypeptide binding]; other site 288681012465 phosphorylation site [posttranslational modification] 288681012466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012467 ATP binding site [chemical binding]; other site 288681012468 Mg2+ binding site [ion binding]; other site 288681012469 G-X-G motif; other site 288681012470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012472 active site 288681012473 phosphorylation site [posttranslational modification] 288681012474 intermolecular recognition site; other site 288681012475 dimerization interface [polypeptide binding]; other site 288681012476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012477 DNA binding site [nucleotide binding] 288681012478 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 288681012479 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 288681012480 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 288681012481 putative RNA binding site [nucleotide binding]; other site 288681012482 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 288681012483 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 288681012484 TrkA-N domain; Region: TrkA_N; pfam02254 288681012485 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 288681012486 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 288681012487 active site 288681012488 catalytic site [active] 288681012489 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681012490 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681012491 Walker A/P-loop; other site 288681012492 ATP binding site [chemical binding]; other site 288681012493 Q-loop/lid; other site 288681012494 ABC transporter signature motif; other site 288681012495 Walker B; other site 288681012496 D-loop; other site 288681012497 H-loop/switch region; other site 288681012498 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 288681012499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681012500 ABC-ATPase subunit interface; other site 288681012501 dimer interface [polypeptide binding]; other site 288681012502 putative PBP binding regions; other site 288681012503 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 288681012504 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288681012505 intersubunit interface [polypeptide binding]; other site 288681012506 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681012507 heme-binding site [chemical binding]; other site 288681012508 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681012509 heme-binding site [chemical binding]; other site 288681012510 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681012511 heme-binding site [chemical binding]; other site 288681012512 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681012513 heme-binding site [chemical binding]; other site 288681012514 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681012515 heme-binding site [chemical binding]; other site 288681012516 heme uptake protein IsdC; Region: IsdC; TIGR03656 288681012517 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 288681012518 heme-binding site [chemical binding]; other site 288681012519 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 288681012520 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 288681012521 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681012522 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681012523 RNA binding surface [nucleotide binding]; other site 288681012524 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 288681012525 probable active site [active] 288681012526 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 288681012527 MutS domain III; Region: MutS_III; pfam05192 288681012528 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 288681012529 Walker A/P-loop; other site 288681012530 ATP binding site [chemical binding]; other site 288681012531 Q-loop/lid; other site 288681012532 ABC transporter signature motif; other site 288681012533 Walker B; other site 288681012534 D-loop; other site 288681012535 H-loop/switch region; other site 288681012536 Smr domain; Region: Smr; pfam01713 288681012537 hypothetical protein; Provisional; Region: PRK08609 288681012538 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 288681012539 active site 288681012540 primer binding site [nucleotide binding]; other site 288681012541 NTP binding site [chemical binding]; other site 288681012542 metal binding triad [ion binding]; metal-binding site 288681012543 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 288681012544 active site 288681012545 Colicin V production protein; Region: Colicin_V; pfam02674 288681012546 cell division protein ZapA; Provisional; Region: PRK14126 288681012547 ribonuclease HIII; Provisional; Region: PRK00996 288681012548 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 288681012549 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 288681012550 RNA/DNA hybrid binding site [nucleotide binding]; other site 288681012551 active site 288681012552 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 288681012553 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 288681012554 putative dimer interface [polypeptide binding]; other site 288681012555 putative anticodon binding site; other site 288681012556 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 288681012557 homodimer interface [polypeptide binding]; other site 288681012558 motif 1; other site 288681012559 motif 2; other site 288681012560 active site 288681012561 motif 3; other site 288681012562 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 288681012563 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 288681012564 putative tRNA-binding site [nucleotide binding]; other site 288681012565 B3/4 domain; Region: B3_4; pfam03483 288681012566 tRNA synthetase B5 domain; Region: B5; smart00874 288681012567 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 288681012568 dimer interface [polypeptide binding]; other site 288681012569 motif 1; other site 288681012570 motif 3; other site 288681012571 motif 2; other site 288681012572 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 288681012573 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 288681012574 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 288681012575 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 288681012576 dimer interface [polypeptide binding]; other site 288681012577 motif 1; other site 288681012578 active site 288681012579 motif 2; other site 288681012580 motif 3; other site 288681012581 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 288681012582 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 288681012583 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 288681012584 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 288681012585 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681012586 Zn2+ binding site [ion binding]; other site 288681012587 Mg2+ binding site [ion binding]; other site 288681012588 CAAX protease self-immunity; Region: Abi; pfam02517 288681012589 CAAX protease self-immunity; Region: Abi; pfam02517 288681012590 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681012591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012592 putative substrate translocation pore; other site 288681012593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681012594 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 288681012595 HlyD family secretion protein; Region: HlyD_3; pfam13437 288681012596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681012597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681012598 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 288681012599 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 288681012600 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 288681012601 oligomer interface [polypeptide binding]; other site 288681012602 active site 288681012603 metal binding site [ion binding]; metal-binding site 288681012604 dUTPase; Region: dUTPase_2; pfam08761 288681012605 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 288681012606 active site 288681012607 homodimer interface [polypeptide binding]; other site 288681012608 metal binding site [ion binding]; metal-binding site 288681012609 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 288681012610 23S rRNA binding site [nucleotide binding]; other site 288681012611 L21 binding site [polypeptide binding]; other site 288681012612 L13 binding site [polypeptide binding]; other site 288681012613 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 288681012614 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 288681012615 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 288681012616 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 288681012617 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 288681012618 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 288681012619 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 288681012620 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 288681012621 active site 288681012622 dimer interface [polypeptide binding]; other site 288681012623 motif 1; other site 288681012624 motif 2; other site 288681012625 motif 3; other site 288681012626 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 288681012627 anticodon binding site; other site 288681012628 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 288681012629 primosomal protein DnaI; Reviewed; Region: PRK08939 288681012630 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 288681012631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681012632 Walker A motif; other site 288681012633 ATP binding site [chemical binding]; other site 288681012634 Walker B motif; other site 288681012635 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 288681012636 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 288681012637 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 288681012638 ATP cone domain; Region: ATP-cone; pfam03477 288681012639 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 288681012640 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 288681012641 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 288681012642 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 288681012643 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 288681012644 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 288681012645 CoA-binding site [chemical binding]; other site 288681012646 ATP-binding [chemical binding]; other site 288681012647 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 288681012648 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 288681012649 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 288681012650 DNA binding site [nucleotide binding] 288681012651 catalytic residue [active] 288681012652 H2TH interface [polypeptide binding]; other site 288681012653 putative catalytic residues [active] 288681012654 turnover-facilitating residue; other site 288681012655 intercalation triad [nucleotide binding]; other site 288681012656 8OG recognition residue [nucleotide binding]; other site 288681012657 putative reading head residues; other site 288681012658 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 288681012659 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 288681012660 DNA polymerase I; Provisional; Region: PRK05755 288681012661 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 288681012662 active site 288681012663 metal binding site 1 [ion binding]; metal-binding site 288681012664 putative 5' ssDNA interaction site; other site 288681012665 metal binding site 3; metal-binding site 288681012666 metal binding site 2 [ion binding]; metal-binding site 288681012667 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 288681012668 putative DNA binding site [nucleotide binding]; other site 288681012669 putative metal binding site [ion binding]; other site 288681012670 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 288681012671 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 288681012672 active site 288681012673 DNA binding site [nucleotide binding] 288681012674 catalytic site [active] 288681012675 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681012676 dimerization interface [polypeptide binding]; other site 288681012677 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 288681012678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681012679 putative active site [active] 288681012680 heme pocket [chemical binding]; other site 288681012681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012682 dimer interface [polypeptide binding]; other site 288681012683 phosphorylation site [posttranslational modification] 288681012684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012685 ATP binding site [chemical binding]; other site 288681012686 Mg2+ binding site [ion binding]; other site 288681012687 G-X-G motif; other site 288681012688 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012690 active site 288681012691 phosphorylation site [posttranslational modification] 288681012692 intermolecular recognition site; other site 288681012693 dimerization interface [polypeptide binding]; other site 288681012694 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012695 DNA binding site [nucleotide binding] 288681012696 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 288681012697 active site 2 [active] 288681012698 active site 1 [active] 288681012699 malate dehydrogenase; Reviewed; Region: PRK06223 288681012700 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 288681012701 NAD(P) binding site [chemical binding]; other site 288681012702 dimer interface [polypeptide binding]; other site 288681012703 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681012704 substrate binding site [chemical binding]; other site 288681012705 isocitrate dehydrogenase; Reviewed; Region: PRK07006 288681012706 isocitrate dehydrogenase; Validated; Region: PRK07362 288681012707 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 288681012708 dimer interface [polypeptide binding]; other site 288681012709 Citrate synthase; Region: Citrate_synt; pfam00285 288681012710 active site 288681012711 citrylCoA binding site [chemical binding]; other site 288681012712 oxalacetate/citrate binding site [chemical binding]; other site 288681012713 coenzyme A binding site [chemical binding]; other site 288681012714 catalytic triad [active] 288681012715 Protein of unknown function (DUF441); Region: DUF441; pfam04284 288681012716 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 288681012717 Domain of unknown function DUF20; Region: UPF0118; pfam01594 288681012718 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 288681012719 pyruvate kinase; Provisional; Region: PRK06354 288681012720 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 288681012721 domain interfaces; other site 288681012722 active site 288681012723 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 288681012724 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 288681012725 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 288681012726 active site 288681012727 ADP/pyrophosphate binding site [chemical binding]; other site 288681012728 dimerization interface [polypeptide binding]; other site 288681012729 allosteric effector site; other site 288681012730 fructose-1,6-bisphosphate binding site; other site 288681012731 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 288681012732 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 288681012733 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 288681012734 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 288681012735 Transcriptional regulators [Transcription]; Region: FadR; COG2186 288681012736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681012737 DNA-binding site [nucleotide binding]; DNA binding site 288681012738 Malic enzyme, N-terminal domain; Region: malic; pfam00390 288681012739 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 288681012740 putative NAD(P) binding site [chemical binding]; other site 288681012741 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 288681012742 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 288681012743 active site 288681012744 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 288681012745 generic binding surface II; other site 288681012746 generic binding surface I; other site 288681012747 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 288681012748 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 288681012749 DHH family; Region: DHH; pfam01368 288681012750 DHHA1 domain; Region: DHHA1; pfam02272 288681012751 YtpI-like protein; Region: YtpI; pfam14007 288681012752 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 288681012753 Phosphotransferase enzyme family; Region: APH; pfam01636 288681012754 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 288681012755 active site 288681012756 ATP binding site [chemical binding]; other site 288681012757 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 288681012758 substrate binding site [chemical binding]; other site 288681012759 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 288681012760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681012761 DNA-binding site [nucleotide binding]; DNA binding site 288681012762 DRTGG domain; Region: DRTGG; pfam07085 288681012763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 288681012764 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 288681012765 active site 2 [active] 288681012766 active site 1 [active] 288681012767 metal-dependent hydrolase; Provisional; Region: PRK00685 288681012768 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 288681012769 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 288681012770 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 288681012771 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 288681012772 active site 288681012773 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 288681012774 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 288681012775 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 288681012776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 288681012777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681012778 Coenzyme A binding pocket [chemical binding]; other site 288681012779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681012780 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681012781 Coenzyme A binding pocket [chemical binding]; other site 288681012782 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 288681012783 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681012784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681012785 non-specific DNA binding site [nucleotide binding]; other site 288681012786 salt bridge; other site 288681012787 sequence-specific DNA binding site [nucleotide binding]; other site 288681012788 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 288681012789 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 288681012790 hexamer interface [polypeptide binding]; other site 288681012791 ligand binding site [chemical binding]; other site 288681012792 putative active site [active] 288681012793 NAD(P) binding site [chemical binding]; other site 288681012794 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 288681012795 classical (c) SDRs; Region: SDR_c; cd05233 288681012796 NAD(P) binding site [chemical binding]; other site 288681012797 active site 288681012798 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 288681012799 Ligand Binding Site [chemical binding]; other site 288681012800 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 288681012801 argininosuccinate lyase; Provisional; Region: PRK00855 288681012802 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 288681012803 active sites [active] 288681012804 tetramer interface [polypeptide binding]; other site 288681012805 argininosuccinate synthase; Provisional; Region: PRK13820 288681012806 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 288681012807 ANP binding site [chemical binding]; other site 288681012808 Substrate Binding Site II [chemical binding]; other site 288681012809 Substrate Binding Site I [chemical binding]; other site 288681012810 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681012811 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681012812 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681012813 EcsC protein family; Region: EcsC; pfam12787 288681012814 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 288681012815 nudix motif; other site 288681012816 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 288681012817 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 288681012818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681012819 S-adenosylmethionine binding site [chemical binding]; other site 288681012820 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 288681012821 dimer interface [polypeptide binding]; other site 288681012822 catalytic triad [active] 288681012823 peroxidatic and resolving cysteines [active] 288681012824 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 288681012825 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 288681012826 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 288681012827 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 288681012828 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 288681012829 active site 288681012830 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681012831 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 288681012832 dimer interface [polypeptide binding]; other site 288681012833 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 288681012834 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 288681012835 active site 288681012836 acyl-activating enzyme (AAE) consensus motif; other site 288681012837 putative CoA binding site [chemical binding]; other site 288681012838 AMP binding site [chemical binding]; other site 288681012839 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681012840 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 288681012841 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 288681012842 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 288681012843 Ligand Binding Site [chemical binding]; other site 288681012844 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 288681012845 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 288681012846 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681012847 catalytic residue [active] 288681012848 septation ring formation regulator EzrA; Provisional; Region: PRK04778 288681012849 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681012850 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681012851 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681012852 dimerization interface [polypeptide binding]; other site 288681012853 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681012854 EamA-like transporter family; Region: EamA; pfam00892 288681012855 EamA-like transporter family; Region: EamA; pfam00892 288681012856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681012857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681012858 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 288681012859 GAF domain; Region: GAF_2; pfam13185 288681012860 methionine gamma-lyase; Provisional; Region: PRK06767 288681012861 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681012862 homodimer interface [polypeptide binding]; other site 288681012863 substrate-cofactor binding pocket; other site 288681012864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681012865 catalytic residue [active] 288681012866 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 288681012867 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 288681012868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681012869 RNA binding surface [nucleotide binding]; other site 288681012870 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 288681012871 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 288681012872 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 288681012873 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 288681012874 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 288681012875 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 288681012876 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 288681012877 active site 288681012878 HIGH motif; other site 288681012879 dimer interface [polypeptide binding]; other site 288681012880 KMSKS motif; other site 288681012881 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681012882 RNA binding surface [nucleotide binding]; other site 288681012883 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 288681012884 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681012885 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681012886 DNA binding residues [nucleotide binding] 288681012887 acetyl-CoA synthetase; Provisional; Region: PRK04319 288681012888 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 288681012889 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 288681012890 active site 288681012891 acyl-activating enzyme (AAE) consensus motif; other site 288681012892 putative CoA binding site [chemical binding]; other site 288681012893 AMP binding site [chemical binding]; other site 288681012894 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681012895 Coenzyme A binding pocket [chemical binding]; other site 288681012896 FOG: CBS domain [General function prediction only]; Region: COG0517 288681012897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 288681012898 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 288681012899 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 288681012900 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 288681012901 active site 288681012902 Zn binding site [ion binding]; other site 288681012903 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681012904 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681012905 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681012906 active site 288681012907 phosphorylation site [posttranslational modification] 288681012908 intermolecular recognition site; other site 288681012909 dimerization interface [polypeptide binding]; other site 288681012910 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681012911 DNA binding site [nucleotide binding] 288681012912 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681012913 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681012914 dimerization interface [polypeptide binding]; other site 288681012915 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681012916 dimer interface [polypeptide binding]; other site 288681012917 phosphorylation site [posttranslational modification] 288681012918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681012919 ATP binding site [chemical binding]; other site 288681012920 Mg2+ binding site [ion binding]; other site 288681012921 G-X-G motif; other site 288681012922 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681012923 Ankyrin repeat; Region: Ank; pfam00023 288681012924 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681012925 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681012926 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 288681012927 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681012928 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681012929 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 288681012930 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 288681012931 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 288681012932 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 288681012933 catabolite control protein A; Region: ccpA; TIGR01481 288681012934 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681012935 DNA binding site [nucleotide binding] 288681012936 domain linker motif; other site 288681012937 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 288681012938 dimerization interface [polypeptide binding]; other site 288681012939 effector binding site; other site 288681012940 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004 288681012941 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 288681012942 putative dimer interface [polypeptide binding]; other site 288681012943 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 288681012944 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 288681012945 putative dimer interface [polypeptide binding]; other site 288681012946 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 288681012947 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 288681012948 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 288681012949 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 288681012950 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681012951 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681012952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681012953 Coenzyme A binding pocket [chemical binding]; other site 288681012954 Predicted transcriptional regulators [Transcription]; Region: COG1695 288681012955 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 288681012956 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 288681012957 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 288681012958 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 288681012959 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 288681012960 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 288681012961 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 288681012962 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 288681012963 active site 288681012964 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 288681012965 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 288681012966 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 288681012967 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 288681012968 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 288681012969 putative tRNA-binding site [nucleotide binding]; other site 288681012970 hypothetical protein; Provisional; Region: PRK13668 288681012971 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681012972 catalytic residues [active] 288681012973 NTPase; Reviewed; Region: PRK03114 288681012974 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 288681012975 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 288681012976 oligomer interface [polypeptide binding]; other site 288681012977 active site 288681012978 metal binding site [ion binding]; metal-binding site 288681012979 Predicted small secreted protein [Function unknown]; Region: COG5584 288681012980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681012981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681012982 S-adenosylmethionine binding site [chemical binding]; other site 288681012983 YtzH-like protein; Region: YtzH; pfam14165 288681012984 Phosphotransferase enzyme family; Region: APH; pfam01636 288681012985 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 288681012986 active site 288681012987 substrate binding site [chemical binding]; other site 288681012988 ATP binding site [chemical binding]; other site 288681012989 pullulanase, type I; Region: pulA_typeI; TIGR02104 288681012990 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 288681012991 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 288681012992 Ca binding site [ion binding]; other site 288681012993 active site 288681012994 catalytic site [active] 288681012995 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 288681012996 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288681012997 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 288681012998 dipeptidase PepV; Reviewed; Region: PRK07318 288681012999 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 288681013000 active site 288681013001 metal binding site [ion binding]; metal-binding site 288681013002 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 288681013003 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 288681013004 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681013005 RNA binding surface [nucleotide binding]; other site 288681013006 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 288681013007 active site 288681013008 uracil binding [chemical binding]; other site 288681013009 stage V sporulation protein B; Region: spore_V_B; TIGR02900 288681013010 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 288681013011 HI0933-like protein; Region: HI0933_like; pfam03486 288681013012 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681013013 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 288681013014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013015 putative substrate translocation pore; other site 288681013016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681013017 dimerization interface [polypeptide binding]; other site 288681013018 putative DNA binding site [nucleotide binding]; other site 288681013019 putative Zn2+ binding site [ion binding]; other site 288681013020 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 288681013021 putative hydrophobic ligand binding site [chemical binding]; other site 288681013022 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 288681013023 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 288681013024 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 288681013025 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 288681013026 glucose-1-dehydrogenase; Provisional; Region: PRK08936 288681013027 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 288681013028 NAD binding site [chemical binding]; other site 288681013029 homodimer interface [polypeptide binding]; other site 288681013030 active site 288681013031 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 288681013032 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 288681013033 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 288681013034 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 288681013035 MoaE interaction surface [polypeptide binding]; other site 288681013036 MoeB interaction surface [polypeptide binding]; other site 288681013037 thiocarboxylated glycine; other site 288681013038 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 288681013039 MoaE homodimer interface [polypeptide binding]; other site 288681013040 MoaD interaction [polypeptide binding]; other site 288681013041 active site residues [active] 288681013042 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 288681013043 Walker A motif; other site 288681013044 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 288681013045 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 288681013046 dimer interface [polypeptide binding]; other site 288681013047 putative functional site; other site 288681013048 putative MPT binding site; other site 288681013049 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 288681013050 trimer interface [polypeptide binding]; other site 288681013051 dimer interface [polypeptide binding]; other site 288681013052 putative active site [active] 288681013053 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 288681013054 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 288681013055 ATP binding site [chemical binding]; other site 288681013056 substrate interface [chemical binding]; other site 288681013057 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 288681013058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681013059 FeS/SAM binding site; other site 288681013060 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 288681013061 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681013062 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 288681013063 active site residue [active] 288681013064 homoserine O-acetyltransferase; Provisional; Region: PRK06765 288681013065 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 288681013066 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681013067 Spore germination protein; Region: Spore_permease; pfam03845 288681013068 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681013069 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681013070 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 288681013071 putative nucleotide binding site [chemical binding]; other site 288681013072 putative metal binding site [ion binding]; other site 288681013073 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 288681013074 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 288681013075 active site 288681013076 HIGH motif; other site 288681013077 KMSKS motif; other site 288681013078 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 288681013079 tRNA binding surface [nucleotide binding]; other site 288681013080 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681013082 putative substrate translocation pore; other site 288681013083 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 288681013084 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681013085 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 288681013086 TrkA-C domain; Region: TrkA_C; pfam02080 288681013087 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 288681013088 Int/Topo IB signature motif; other site 288681013089 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681013090 FtsX-like permease family; Region: FtsX; pfam02687 288681013091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681013092 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681013093 Walker A/P-loop; other site 288681013094 ATP binding site [chemical binding]; other site 288681013095 Q-loop/lid; other site 288681013096 ABC transporter signature motif; other site 288681013097 Walker B; other site 288681013098 D-loop; other site 288681013099 H-loop/switch region; other site 288681013100 Predicted membrane protein [Function unknown]; Region: COG2311 288681013101 Protein of unknown function (DUF418); Region: DUF418; cl12135 288681013102 Protein of unknown function (DUF418); Region: DUF418; pfam04235 288681013103 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 288681013104 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 288681013105 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681013106 FeS/SAM binding site; other site 288681013107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681013108 S-adenosylmethionine binding site [chemical binding]; other site 288681013109 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 288681013110 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681013111 Walker A/P-loop; other site 288681013112 ATP binding site [chemical binding]; other site 288681013113 Q-loop/lid; other site 288681013114 ABC transporter signature motif; other site 288681013115 Walker B; other site 288681013116 D-loop; other site 288681013117 H-loop/switch region; other site 288681013118 aspartate racemase; Region: asp_race; TIGR00035 288681013119 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 288681013120 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 288681013121 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 288681013122 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 288681013123 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 288681013124 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 288681013125 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681013126 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681013127 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 288681013128 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 288681013129 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 288681013130 trimer interface [polypeptide binding]; other site 288681013131 putative metal binding site [ion binding]; other site 288681013132 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 288681013133 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 288681013134 active site 288681013135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681013136 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 288681013137 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 288681013138 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 288681013139 GTP binding site; other site 288681013140 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 288681013141 MPT binding site; other site 288681013142 trimer interface [polypeptide binding]; other site 288681013143 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681013144 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681013145 S-adenosylmethionine synthetase; Validated; Region: PRK05250 288681013146 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 288681013147 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 288681013148 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 288681013149 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 288681013150 active site 288681013151 substrate-binding site [chemical binding]; other site 288681013152 metal-binding site [ion binding] 288681013153 ATP binding site [chemical binding]; other site 288681013154 ATP synthase I chain; Region: ATP_synt_I; pfam03899 288681013155 EamA-like transporter family; Region: EamA; pfam00892 288681013156 EamA-like transporter family; Region: EamA; pfam00892 288681013157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 288681013158 Uncharacterized conserved protein [Function unknown]; Region: COG0327 288681013159 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 288681013160 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681013161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013162 motif II; other site 288681013163 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 288681013164 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 288681013165 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 288681013166 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681013167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013168 motif II; other site 288681013169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013170 ATP binding site [chemical binding]; other site 288681013171 Mg2+ binding site [ion binding]; other site 288681013172 G-X-G motif; other site 288681013173 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013174 dimer interface [polypeptide binding]; other site 288681013175 phosphorylation site [posttranslational modification] 288681013176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013177 ATP binding site [chemical binding]; other site 288681013178 Mg2+ binding site [ion binding]; other site 288681013179 G-X-G motif; other site 288681013180 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681013181 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 288681013182 Secretory lipase; Region: LIP; pfam03583 288681013183 Sulfatase; Region: Sulfatase; pfam00884 288681013184 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 288681013185 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 288681013186 NMT1-like family; Region: NMT1_2; pfam13379 288681013187 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 288681013188 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 288681013189 Walker A/P-loop; other site 288681013190 ATP binding site [chemical binding]; other site 288681013191 Q-loop/lid; other site 288681013192 ABC transporter signature motif; other site 288681013193 Walker B; other site 288681013194 D-loop; other site 288681013195 H-loop/switch region; other site 288681013196 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 288681013197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681013198 dimer interface [polypeptide binding]; other site 288681013199 conserved gate region; other site 288681013200 putative PBP binding loops; other site 288681013201 ABC-ATPase subunit interface; other site 288681013202 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 288681013203 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013204 motif II; other site 288681013205 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 288681013206 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 288681013207 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 288681013208 nudix motif; other site 288681013209 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 288681013210 S-ribosylhomocysteinase; Provisional; Region: PRK02260 288681013211 hypothetical protein; Validated; Region: PRK00041 288681013212 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 288681013213 active site clefts [active] 288681013214 zinc binding site [ion binding]; other site 288681013215 dimer interface [polypeptide binding]; other site 288681013216 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 288681013217 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 288681013218 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 288681013219 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681013220 S-layer homology domain; Region: SLH; pfam00395 288681013221 S-layer homology domain; Region: SLH; pfam00395 288681013222 S-layer homology domain; Region: SLH; pfam00395 288681013223 Excalibur calcium-binding domain; Region: Excalibur; smart00894 288681013224 Uncharacterized conserved protein [Function unknown]; Region: COG1434 288681013225 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 288681013226 putative active site [active] 288681013227 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681013228 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681013229 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681013230 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 288681013231 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 288681013232 Predicted membrane protein [Function unknown]; Region: COG3766 288681013233 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 288681013234 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 288681013235 hypothetical protein; Provisional; Region: PRK12473 288681013236 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 288681013237 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 288681013238 G1 box; other site 288681013239 GTP/Mg2+ binding site [chemical binding]; other site 288681013240 Switch I region; other site 288681013241 G2 box; other site 288681013242 G3 box; other site 288681013243 Switch II region; other site 288681013244 G4 box; other site 288681013245 G5 box; other site 288681013246 Nucleoside recognition; Region: Gate; pfam07670 288681013247 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 288681013248 Nucleoside recognition; Region: Gate; pfam07670 288681013249 FeoA domain; Region: FeoA; pfam04023 288681013250 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 288681013251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681013252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013253 dimerization interface [polypeptide binding]; other site 288681013254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013255 dimer interface [polypeptide binding]; other site 288681013256 phosphorylation site [posttranslational modification] 288681013257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013258 ATP binding site [chemical binding]; other site 288681013259 Mg2+ binding site [ion binding]; other site 288681013260 G-X-G motif; other site 288681013261 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013263 active site 288681013264 phosphorylation site [posttranslational modification] 288681013265 intermolecular recognition site; other site 288681013266 dimerization interface [polypeptide binding]; other site 288681013267 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013268 DNA binding site [nucleotide binding] 288681013269 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 288681013270 active site 288681013271 catalytic site [active] 288681013272 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681013273 active site 288681013274 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 288681013275 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 288681013276 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681013277 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681013278 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 288681013279 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 288681013280 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 288681013281 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681013282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681013283 S-adenosylmethionine binding site [chemical binding]; other site 288681013284 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 288681013285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681013286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681013287 YolD-like protein; Region: YolD; pfam08863 288681013288 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681013289 FtsX-like permease family; Region: FtsX; pfam02687 288681013290 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681013291 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681013292 Walker A/P-loop; other site 288681013293 ATP binding site [chemical binding]; other site 288681013294 Q-loop/lid; other site 288681013295 ABC transporter signature motif; other site 288681013296 Walker B; other site 288681013297 D-loop; other site 288681013298 H-loop/switch region; other site 288681013299 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 288681013300 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681013301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 288681013302 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 288681013303 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681013304 Walker A/P-loop; other site 288681013305 ATP binding site [chemical binding]; other site 288681013306 Q-loop/lid; other site 288681013307 ABC transporter signature motif; other site 288681013308 Walker B; other site 288681013309 D-loop; other site 288681013310 H-loop/switch region; other site 288681013311 Predicted integral membrane protein [Function unknown]; Region: COG5658 288681013312 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 288681013313 SdpI/YhfL protein family; Region: SdpI; pfam13630 288681013314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681013315 dimerization interface [polypeptide binding]; other site 288681013316 putative DNA binding site [nucleotide binding]; other site 288681013317 putative Zn2+ binding site [ion binding]; other site 288681013318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013320 active site 288681013321 phosphorylation site [posttranslational modification] 288681013322 intermolecular recognition site; other site 288681013323 dimerization interface [polypeptide binding]; other site 288681013324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013325 DNA binding site [nucleotide binding] 288681013326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681013327 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 288681013328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013329 ATP binding site [chemical binding]; other site 288681013330 Mg2+ binding site [ion binding]; other site 288681013331 G-X-G motif; other site 288681013332 FtsX-like permease family; Region: FtsX; pfam02687 288681013333 FtsX-like permease family; Region: FtsX; pfam02687 288681013334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681013335 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681013336 Walker A/P-loop; other site 288681013337 ATP binding site [chemical binding]; other site 288681013338 Q-loop/lid; other site 288681013339 ABC transporter signature motif; other site 288681013340 Walker B; other site 288681013341 D-loop; other site 288681013342 H-loop/switch region; other site 288681013343 FtsX-like permease family; Region: FtsX; pfam02687 288681013344 GntP family permease; Region: GntP_permease; pfam02447 288681013345 fructuronate transporter; Provisional; Region: PRK10034; cl15264 288681013346 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 288681013347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681013348 DNA-binding site [nucleotide binding]; DNA binding site 288681013349 UTRA domain; Region: UTRA; pfam07702 288681013350 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681013351 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681013352 substrate binding site [chemical binding]; other site 288681013353 ATP binding site [chemical binding]; other site 288681013354 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 288681013355 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 288681013356 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681013357 catalytic residue [active] 288681013358 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 288681013359 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 288681013360 active site 288681013361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681013362 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681013363 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 288681013364 dimerization interface [polypeptide binding]; other site 288681013365 putative uracil/xanthine transporter; Provisional; Region: PRK11412 288681013366 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 288681013367 nucleoside/Zn binding site; other site 288681013368 dimer interface [polypeptide binding]; other site 288681013369 catalytic motif [active] 288681013370 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 288681013371 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681013372 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013373 dimerization interface [polypeptide binding]; other site 288681013374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013375 dimer interface [polypeptide binding]; other site 288681013376 phosphorylation site [posttranslational modification] 288681013377 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013378 ATP binding site [chemical binding]; other site 288681013379 Mg2+ binding site [ion binding]; other site 288681013380 G-X-G motif; other site 288681013381 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013383 active site 288681013384 phosphorylation site [posttranslational modification] 288681013385 intermolecular recognition site; other site 288681013386 dimerization interface [polypeptide binding]; other site 288681013387 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013388 DNA binding site [nucleotide binding] 288681013389 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 288681013390 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 288681013391 active site 288681013392 octamer interface [polypeptide binding]; other site 288681013393 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 288681013394 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 288681013395 acyl-activating enzyme (AAE) consensus motif; other site 288681013396 putative AMP binding site [chemical binding]; other site 288681013397 putative active site [active] 288681013398 putative CoA binding site [chemical binding]; other site 288681013399 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681013400 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 288681013401 substrate binding site [chemical binding]; other site 288681013402 oxyanion hole (OAH) forming residues; other site 288681013403 trimer interface [polypeptide binding]; other site 288681013404 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 288681013405 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 288681013406 nucleophilic elbow; other site 288681013407 catalytic triad; other site 288681013408 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 288681013409 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 288681013410 dimer interface [polypeptide binding]; other site 288681013411 tetramer interface [polypeptide binding]; other site 288681013412 PYR/PP interface [polypeptide binding]; other site 288681013413 TPP binding site [chemical binding]; other site 288681013414 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 288681013415 TPP-binding site; other site 288681013416 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 288681013417 chorismate binding enzyme; Region: Chorismate_bind; cl10555 288681013418 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 288681013419 putative active site [active] 288681013420 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 288681013421 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288681013422 DNA-binding site [nucleotide binding]; DNA binding site 288681013423 RNA-binding motif; other site 288681013424 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 288681013425 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 288681013426 active site flap/lid [active] 288681013427 nucleophilic elbow; other site 288681013428 catalytic triad [active] 288681013429 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 288681013430 homodimer interface [polypeptide binding]; other site 288681013431 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 288681013432 active site pocket [active] 288681013433 glycogen synthase; Provisional; Region: glgA; PRK00654 288681013434 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 288681013435 ADP-binding pocket [chemical binding]; other site 288681013436 homodimer interface [polypeptide binding]; other site 288681013437 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 288681013438 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 288681013439 ligand binding site; other site 288681013440 oligomer interface; other site 288681013441 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 288681013442 dimer interface [polypeptide binding]; other site 288681013443 N-terminal domain interface [polypeptide binding]; other site 288681013444 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 288681013445 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 288681013446 ligand binding site; other site 288681013447 oligomer interface; other site 288681013448 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 288681013449 dimer interface [polypeptide binding]; other site 288681013450 N-terminal domain interface [polypeptide binding]; other site 288681013451 sulfate 1 binding site; other site 288681013452 glycogen branching enzyme; Provisional; Region: PRK12313 288681013453 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 288681013454 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 288681013455 active site 288681013456 catalytic site [active] 288681013457 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 288681013458 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 288681013459 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 288681013460 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681013461 putative active site [active] 288681013462 catalytic triad [active] 288681013463 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 288681013464 PA/protease domain interface [polypeptide binding]; other site 288681013465 putative integrin binding motif; other site 288681013466 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 288681013467 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 288681013468 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 288681013469 dockerin binding interface; other site 288681013470 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 288681013471 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 288681013472 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681013473 NAD binding site [chemical binding]; other site 288681013474 dimer interface [polypeptide binding]; other site 288681013475 substrate binding site [chemical binding]; other site 288681013476 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 288681013477 MgtC family; Region: MgtC; pfam02308 288681013478 Ion channel; Region: Ion_trans_2; pfam07885 288681013479 TrkA-N domain; Region: TrkA_N; pfam02254 288681013480 YugN-like family; Region: YugN; pfam08868 288681013481 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 288681013482 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 288681013483 active site 288681013484 dimer interface [polypeptide binding]; other site 288681013485 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 288681013486 dimer interface [polypeptide binding]; other site 288681013487 active site 288681013488 Domain of unknown function (DUF378); Region: DUF378; pfam04070 288681013489 general stress protein 13; Validated; Region: PRK08059 288681013490 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681013491 RNA binding site [nucleotide binding]; other site 288681013492 hypothetical protein; Validated; Region: PRK07682 288681013493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681013494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681013495 homodimer interface [polypeptide binding]; other site 288681013496 catalytic residue [active] 288681013497 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288681013498 AsnC family; Region: AsnC_trans_reg; pfam01037 288681013499 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 288681013500 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 288681013501 dimerization interface [polypeptide binding]; other site 288681013502 ligand binding site [chemical binding]; other site 288681013503 NADP binding site [chemical binding]; other site 288681013504 catalytic site [active] 288681013505 Putative lysophospholipase; Region: Hydrolase_4; cl19140 288681013506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681013507 Putative lysophospholipase; Region: Hydrolase_4; cl19140 288681013508 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 288681013509 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 288681013510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681013511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681013512 homodimer interface [polypeptide binding]; other site 288681013513 catalytic residue [active] 288681013514 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 288681013515 E-class dimer interface [polypeptide binding]; other site 288681013516 P-class dimer interface [polypeptide binding]; other site 288681013517 active site 288681013518 Cu2+ binding site [ion binding]; other site 288681013519 Zn2+ binding site [ion binding]; other site 288681013520 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 288681013521 Kinase associated protein B; Region: KapB; pfam08810 288681013522 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 288681013523 active site 288681013524 catalytic site [active] 288681013525 substrate binding site [chemical binding]; other site 288681013526 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 288681013527 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 288681013528 transmembrane helices; other site 288681013529 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 288681013530 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 288681013531 active site 288681013532 glycyl-tRNA synthetase; Provisional; Region: PRK04173 288681013533 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 288681013534 dimer interface [polypeptide binding]; other site 288681013535 motif 1; other site 288681013536 active site 288681013537 motif 2; other site 288681013538 motif 3; other site 288681013539 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 288681013540 anticodon binding site; other site 288681013541 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 288681013542 CoenzymeA binding site [chemical binding]; other site 288681013543 subunit interaction site [polypeptide binding]; other site 288681013544 PHB binding site; other site 288681013545 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 288681013546 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 288681013547 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 288681013548 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 288681013549 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 288681013550 active site 288681013551 tetramer interface; other site 288681013552 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 288681013553 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 288681013554 active site 288681013555 substrate binding site [chemical binding]; other site 288681013556 metal binding site [ion binding]; metal-binding site 288681013557 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 288681013558 Uncharacterized conserved protein [Function unknown]; Region: COG1624 288681013559 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 288681013560 multifunctional aminopeptidase A; Provisional; Region: PRK00913 288681013561 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 288681013562 interface (dimer of trimers) [polypeptide binding]; other site 288681013563 Substrate-binding/catalytic site; other site 288681013564 Zn-binding sites [ion binding]; other site 288681013565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 288681013566 Putative membrane protein; Region: YuiB; pfam14068 288681013567 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 288681013568 nudix motif; other site 288681013569 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288681013570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681013571 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 288681013572 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 288681013573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681013574 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013575 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013576 Domain of unknown function DUF11; Region: DUF11; pfam01345 288681013577 Domain of unknown function DUF11; Region: DUF11; pfam01345 288681013578 Domain of unknown function DUF11; Region: DUF11; pfam01345 288681013579 Domain of unknown function DUF11; Region: DUF11; pfam01345 288681013580 Domain of unknown function DUF11; Region: DUF11; pfam01345 288681013581 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013582 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013583 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013584 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013585 Domain of unknown function DUF11; Region: DUF11; cl17728 288681013586 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013587 conserved repeat domain; Region: B_ant_repeat; TIGR01451 288681013588 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013589 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013590 Domain of unknown function DUF11; Region: DUF11; pfam01345 288681013591 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 288681013592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 288681013593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013594 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681013595 putative substrate translocation pore; other site 288681013596 Helix-turn-helix domain; Region: HTH_36; pfam13730 288681013597 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 288681013598 Protein of unknown function (DUF523); Region: DUF523; pfam04463 288681013599 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 288681013600 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681013601 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681013602 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 288681013603 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 288681013604 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288681013605 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 288681013606 hypothetical protein; Provisional; Region: PRK13669 288681013607 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288681013608 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681013609 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 288681013610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681013611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681013612 Walker A/P-loop; other site 288681013613 ATP binding site [chemical binding]; other site 288681013614 Q-loop/lid; other site 288681013615 ABC transporter signature motif; other site 288681013616 Walker B; other site 288681013617 D-loop; other site 288681013618 H-loop/switch region; other site 288681013619 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 288681013620 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 288681013621 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 288681013622 PhnA protein; Region: PhnA; pfam03831 288681013623 CAAX protease self-immunity; Region: Abi; pfam02517 288681013624 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681013625 active site 288681013626 NTP binding site [chemical binding]; other site 288681013627 metal binding triad [ion binding]; metal-binding site 288681013628 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 288681013629 NifU-like domain; Region: NifU; pfam01106 288681013630 spore coat protein YutH; Region: spore_yutH; TIGR02905 288681013631 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 288681013632 tetramer interfaces [polypeptide binding]; other site 288681013633 binuclear metal-binding site [ion binding]; other site 288681013634 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 288681013635 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 288681013636 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288681013637 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 288681013638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013639 active site 288681013640 motif I; other site 288681013641 motif II; other site 288681013642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681013643 Predicted transcriptional regulator [Transcription]; Region: COG2345 288681013644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681013645 putative Zn2+ binding site [ion binding]; other site 288681013646 putative DNA binding site [nucleotide binding]; other site 288681013647 Uncharacterized conserved protein [Function unknown]; Region: COG2445 288681013648 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 288681013649 putative active site [active] 288681013650 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 288681013651 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 288681013652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681013653 RNA binding surface [nucleotide binding]; other site 288681013654 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 288681013655 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 288681013656 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681013657 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681013658 DNA binding residues [nucleotide binding] 288681013659 dimer interface [polypeptide binding]; other site 288681013660 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681013661 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 288681013662 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 288681013663 catalytic core [active] 288681013664 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 288681013665 putative deacylase active site [active] 288681013666 lipoyl synthase; Provisional; Region: PRK05481 288681013667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681013668 FeS/SAM binding site; other site 288681013669 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681013670 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681013671 sporulation protein YunB; Region: spo_yunB; TIGR02832 288681013672 Uncharacterized conserved protein [Function unknown]; Region: COG3377 288681013673 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 288681013674 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 288681013675 active site 288681013676 metal binding site [ion binding]; metal-binding site 288681013677 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 288681013678 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 288681013679 FeS assembly protein SufB; Region: sufB; TIGR01980 288681013680 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 288681013681 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 288681013682 trimerization site [polypeptide binding]; other site 288681013683 active site 288681013684 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 288681013685 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 288681013686 catalytic residue [active] 288681013687 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 288681013688 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 288681013689 FeS assembly protein SufD; Region: sufD; TIGR01981 288681013690 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 288681013691 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 288681013692 Walker A/P-loop; other site 288681013693 ATP binding site [chemical binding]; other site 288681013694 Q-loop/lid; other site 288681013695 ABC transporter signature motif; other site 288681013696 Walker B; other site 288681013697 D-loop; other site 288681013698 H-loop/switch region; other site 288681013699 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 288681013700 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 288681013701 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 288681013702 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 288681013703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681013704 ABC-ATPase subunit interface; other site 288681013705 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 288681013706 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 288681013707 Walker A/P-loop; other site 288681013708 ATP binding site [chemical binding]; other site 288681013709 Q-loop/lid; other site 288681013710 ABC transporter signature motif; other site 288681013711 Walker B; other site 288681013712 D-loop; other site 288681013713 H-loop/switch region; other site 288681013714 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 288681013715 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681013716 catalytic residues [active] 288681013717 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 288681013718 putative active site [active] 288681013719 putative metal binding site [ion binding]; other site 288681013720 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 288681013721 lipoyl attachment site [posttranslational modification]; other site 288681013722 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 288681013723 ArsC family; Region: ArsC; pfam03960 288681013724 putative ArsC-like catalytic residues; other site 288681013725 putative TRX-like catalytic residues [active] 288681013726 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 288681013727 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 288681013728 active site 288681013729 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 288681013730 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 288681013731 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 288681013732 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 288681013733 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681013734 NAD binding site [chemical binding]; other site 288681013735 dimer interface [polypeptide binding]; other site 288681013736 substrate binding site [chemical binding]; other site 288681013737 Coat F domain; Region: Coat_F; pfam07875 288681013738 CAAX protease self-immunity; Region: Abi; pfam02517 288681013739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681013740 salt bridge; other site 288681013741 non-specific DNA binding site [nucleotide binding]; other site 288681013742 sequence-specific DNA binding site [nucleotide binding]; other site 288681013743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681013744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681013745 WHG domain; Region: WHG; pfam13305 288681013746 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 288681013747 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 288681013748 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681013749 active site 288681013750 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 288681013751 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681013752 dimer interface [polypeptide binding]; other site 288681013753 active site 288681013754 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 288681013755 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288681013756 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681013757 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681013758 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 288681013759 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 288681013760 substrate binding site [chemical binding]; other site 288681013761 oxyanion hole (OAH) forming residues; other site 288681013762 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681013763 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681013764 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 288681013765 Proline dehydrogenase; Region: Pro_dh; pfam01619 288681013766 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 288681013767 Domain of unknown function DUF77; Region: DUF77; pfam01910 288681013768 Cache domain; Region: Cache_1; pfam02743 288681013769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013770 dimerization interface [polypeptide binding]; other site 288681013771 Microvirus H protein (pilot protein); Region: Microvir_H; cl11620 288681013772 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681013773 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013774 dimer interface [polypeptide binding]; other site 288681013775 putative CheW interface [polypeptide binding]; other site 288681013776 Predicted transcriptional regulators [Transcription]; Region: COG1378 288681013777 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 288681013778 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 288681013779 C-terminal domain interface [polypeptide binding]; other site 288681013780 sugar binding site [chemical binding]; other site 288681013781 TQXA domain; Region: TQXA_dom; TIGR03934 288681013782 Cna protein B-type domain; Region: Cna_B; pfam05738 288681013783 Cna protein B-type domain; Region: Cna_B; pfam05738 288681013784 Cna protein B-type domain; Region: Cna_B; pfam05738 288681013785 Cna protein B-type domain; Region: Cna_B; pfam05738 288681013786 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681013787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013788 putative substrate translocation pore; other site 288681013789 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 288681013790 Spore germination protein; Region: Spore_permease; cl17796 288681013791 MAEBL; Provisional; Region: PTZ00121 288681013792 OxaA-like protein precursor; Validated; Region: PRK01622 288681013793 Uncharacterized conserved protein [Function unknown]; Region: COG1284 288681013794 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681013795 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 288681013796 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 288681013797 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 288681013798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681013799 hypothetical protein; Provisional; Region: PRK06758 288681013800 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 288681013801 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013802 dimerization interface [polypeptide binding]; other site 288681013803 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013804 dimer interface [polypeptide binding]; other site 288681013805 phosphorylation site [posttranslational modification] 288681013806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013807 ATP binding site [chemical binding]; other site 288681013808 Mg2+ binding site [ion binding]; other site 288681013809 G-X-G motif; other site 288681013810 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013812 active site 288681013813 phosphorylation site [posttranslational modification] 288681013814 intermolecular recognition site; other site 288681013815 dimerization interface [polypeptide binding]; other site 288681013816 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013817 DNA binding site [nucleotide binding] 288681013818 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 288681013819 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681013820 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 288681013821 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 288681013822 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681013823 Walker A/P-loop; other site 288681013824 ATP binding site [chemical binding]; other site 288681013825 Q-loop/lid; other site 288681013826 ABC transporter signature motif; other site 288681013827 Walker B; other site 288681013828 D-loop; other site 288681013829 H-loop/switch region; other site 288681013830 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 288681013831 active site 288681013832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681013833 non-specific DNA binding site [nucleotide binding]; other site 288681013834 salt bridge; other site 288681013835 sequence-specific DNA binding site [nucleotide binding]; other site 288681013836 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681013837 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 288681013838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 288681013839 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 288681013840 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013842 active site 288681013843 phosphorylation site [posttranslational modification] 288681013844 intermolecular recognition site; other site 288681013845 dimerization interface [polypeptide binding]; other site 288681013846 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013847 DNA binding site [nucleotide binding] 288681013848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 288681013849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681013850 dimer interface [polypeptide binding]; other site 288681013851 phosphorylation site [posttranslational modification] 288681013852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681013853 ATP binding site [chemical binding]; other site 288681013854 Mg2+ binding site [ion binding]; other site 288681013855 G-X-G motif; other site 288681013856 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681013857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681013858 S-adenosylmethionine binding site [chemical binding]; other site 288681013859 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013860 dimerization interface [polypeptide binding]; other site 288681013861 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013862 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681013863 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013864 dimer interface [polypeptide binding]; other site 288681013865 putative CheW interface [polypeptide binding]; other site 288681013866 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 288681013867 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681013868 dimerization interface [polypeptide binding]; other site 288681013869 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013870 dimer interface [polypeptide binding]; other site 288681013871 putative CheW interface [polypeptide binding]; other site 288681013872 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 288681013873 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681013874 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681013875 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 288681013876 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681013877 active site 288681013878 Zn binding site [ion binding]; other site 288681013879 Pirin-related protein [General function prediction only]; Region: COG1741 288681013880 Pirin; Region: Pirin; pfam02678 288681013881 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681013882 MarR family; Region: MarR_2; pfam12802 288681013883 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 288681013884 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 288681013885 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 288681013886 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 288681013887 TrkA-C domain; Region: TrkA_C; pfam02080 288681013888 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681013889 amino acid carrier protein; Region: agcS; TIGR00835 288681013890 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 288681013891 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 288681013892 dimerization interface [polypeptide binding]; other site 288681013893 DPS ferroxidase diiron center [ion binding]; other site 288681013894 ion pore; other site 288681013895 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 288681013896 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 288681013897 metal binding site [ion binding]; metal-binding site 288681013898 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 288681013899 Ferritin-like domain; Region: Ferritin; pfam00210 288681013900 ferroxidase diiron center [ion binding]; other site 288681013901 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681013902 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681013903 Nucleoside recognition; Region: Gate; pfam07670 288681013904 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681013905 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681013906 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681013907 Nucleoside recognition; Region: Gate; pfam07670 288681013908 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681013909 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681013910 amino acid carrier protein; Region: agcS; TIGR00835 288681013911 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 288681013912 amino acid carrier protein; Region: agcS; TIGR00835 288681013913 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 288681013914 NADH(P)-binding; Region: NAD_binding_10; pfam13460 288681013915 NAD binding site [chemical binding]; other site 288681013916 substrate binding site [chemical binding]; other site 288681013917 putative active site [active] 288681013918 Peptidase M60-like family; Region: M60-like; pfam13402 288681013919 TQXA domain; Region: TQXA_dom; TIGR03934 288681013920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 288681013921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 288681013922 active site 288681013923 catalytic tetrad [active] 288681013924 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 288681013925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681013926 putative substrate translocation pore; other site 288681013927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681013928 dimerization interface [polypeptide binding]; other site 288681013929 putative DNA binding site [nucleotide binding]; other site 288681013930 putative Zn2+ binding site [ion binding]; other site 288681013931 Uncharacterized conserved protein [Function unknown]; Region: COG2427 288681013932 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 288681013933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681013934 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 288681013935 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 288681013936 active site 288681013937 HIGH motif; other site 288681013938 dimer interface [polypeptide binding]; other site 288681013939 KMSKS motif; other site 288681013940 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 288681013941 RNA binding surface [nucleotide binding]; other site 288681013942 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 288681013943 FAD binding domain; Region: FAD_binding_4; pfam01565 288681013944 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 288681013945 SET domain; Region: SET; pfam00856 288681013946 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 288681013947 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681013948 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681013949 dimer interface [polypeptide binding]; other site 288681013950 putative CheW interface [polypeptide binding]; other site 288681013951 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 288681013952 putative phosphate binding site [ion binding]; other site 288681013953 camphor resistance protein CrcB; Provisional; Region: PRK14219 288681013954 camphor resistance protein CrcB; Provisional; Region: PRK14205 288681013955 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 288681013956 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 288681013957 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681013958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681013959 Coenzyme A binding pocket [chemical binding]; other site 288681013960 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 288681013961 Nuclease-related domain; Region: NERD; pfam08378 288681013962 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681013963 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681013964 putative DNA binding site [nucleotide binding]; other site 288681013965 putative Zn2+ binding site [ion binding]; other site 288681013966 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 288681013967 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681013968 Walker A/P-loop; other site 288681013969 ATP binding site [chemical binding]; other site 288681013970 Q-loop/lid; other site 288681013971 ABC transporter signature motif; other site 288681013972 Walker B; other site 288681013973 D-loop; other site 288681013974 H-loop/switch region; other site 288681013975 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681013976 ABC-ATPase subunit interface; other site 288681013977 dimer interface [polypeptide binding]; other site 288681013978 putative PBP binding regions; other site 288681013979 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681013980 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681013981 ABC-ATPase subunit interface; other site 288681013982 dimer interface [polypeptide binding]; other site 288681013983 putative PBP binding regions; other site 288681013984 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 288681013985 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 288681013986 putative ligand binding residues [chemical binding]; other site 288681013987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681013988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681013989 active site 288681013990 phosphorylation site [posttranslational modification] 288681013991 intermolecular recognition site; other site 288681013992 dimerization interface [polypeptide binding]; other site 288681013993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681013994 DNA binding site [nucleotide binding] 288681013995 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 288681013996 SmpB-tmRNA interface; other site 288681013997 ribonuclease R; Region: RNase_R; TIGR02063 288681013998 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 288681013999 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681014000 RNB domain; Region: RNB; pfam00773 288681014001 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 288681014002 RNA binding site [nucleotide binding]; other site 288681014003 Esterase/lipase [General function prediction only]; Region: COG1647 288681014004 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 288681014005 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 288681014006 holin-like protein; Validated; Region: PRK01658 288681014007 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 288681014008 active site 288681014009 enolase; Provisional; Region: eno; PRK00077 288681014010 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 288681014011 dimer interface [polypeptide binding]; other site 288681014012 metal binding site [ion binding]; metal-binding site 288681014013 substrate binding pocket [chemical binding]; other site 288681014014 phosphoglyceromutase; Provisional; Region: PRK05434 288681014015 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 288681014016 substrate binding site [chemical binding]; other site 288681014017 dimer interface [polypeptide binding]; other site 288681014018 catalytic triad [active] 288681014019 Phosphoglycerate kinase; Region: PGK; pfam00162 288681014020 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 288681014021 substrate binding site [chemical binding]; other site 288681014022 hinge regions; other site 288681014023 ADP binding site [chemical binding]; other site 288681014024 catalytic site [active] 288681014025 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 288681014026 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 288681014027 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 288681014028 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 288681014029 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 288681014030 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 288681014031 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 288681014032 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 288681014033 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 288681014034 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 288681014035 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 288681014036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681014038 TPR motif; other site 288681014039 binding surface 288681014040 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681014041 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 288681014042 stage V sporulation protein AD; Provisional; Region: PRK12404 288681014043 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 288681014044 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 288681014045 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681014046 Predicted membrane protein [Function unknown]; Region: COG2323 288681014047 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681014048 Clp protease; Region: CLP_protease; pfam00574 288681014049 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 288681014050 oligomer interface [polypeptide binding]; other site 288681014051 active site residues [active] 288681014052 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 288681014053 dimerization domain swap beta strand [polypeptide binding]; other site 288681014054 regulatory protein interface [polypeptide binding]; other site 288681014055 active site 288681014056 regulatory phosphorylation site [posttranslational modification]; other site 288681014057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 288681014058 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 288681014059 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 288681014060 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 288681014061 phosphate binding site [ion binding]; other site 288681014062 putative substrate binding pocket [chemical binding]; other site 288681014063 dimer interface [polypeptide binding]; other site 288681014064 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 288681014065 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681014066 putative active site [active] 288681014067 nucleotide binding site [chemical binding]; other site 288681014068 nudix motif; other site 288681014069 putative metal binding site [ion binding]; other site 288681014070 Domain of unknown function (DUF368); Region: DUF368; pfam04018 288681014071 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 288681014072 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681014073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681014074 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681014075 binding surface 288681014076 TPR motif; other site 288681014077 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014078 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681014079 binding surface 288681014080 Tetratricopeptide repeat; Region: TPR_16; pfam13432 288681014081 TPR motif; other site 288681014082 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 288681014083 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 288681014084 trimer interface [polypeptide binding]; other site 288681014085 active site 288681014086 substrate binding site [chemical binding]; other site 288681014087 CoA binding site [chemical binding]; other site 288681014088 pyrophosphatase PpaX; Provisional; Region: PRK13288 288681014089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014090 active site 288681014091 motif I; other site 288681014092 motif II; other site 288681014093 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 288681014094 HPr kinase/phosphorylase; Provisional; Region: PRK05428 288681014095 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 288681014096 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 288681014097 Hpr binding site; other site 288681014098 active site 288681014099 homohexamer subunit interaction site [polypeptide binding]; other site 288681014100 Predicted membrane protein [Function unknown]; Region: COG1950 288681014101 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 288681014102 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 288681014103 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 288681014104 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 288681014105 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 288681014106 excinuclease ABC subunit B; Provisional; Region: PRK05298 288681014107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681014108 ATP binding site [chemical binding]; other site 288681014109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681014110 nucleotide binding region [chemical binding]; other site 288681014111 ATP-binding site [chemical binding]; other site 288681014112 Ultra-violet resistance protein B; Region: UvrB; pfam12344 288681014113 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 288681014114 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681014115 DNA binding residues [nucleotide binding] 288681014116 dimer interface [polypeptide binding]; other site 288681014117 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 288681014118 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681014119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681014120 non-specific DNA binding site [nucleotide binding]; other site 288681014121 salt bridge; other site 288681014122 sequence-specific DNA binding site [nucleotide binding]; other site 288681014123 Predicted membrane protein [Function unknown]; Region: COG2855 288681014124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681014125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681014126 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 288681014127 putative dimerization interface [polypeptide binding]; other site 288681014128 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 288681014129 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681014130 DNA binding residues [nucleotide binding] 288681014131 putative dimer interface [polypeptide binding]; other site 288681014132 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 288681014133 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 288681014134 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 288681014135 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681014136 ABC transporter; Region: ABC_tran_2; pfam12848 288681014137 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681014138 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681014139 hypothetical protein; Provisional; Region: PRK12855 288681014140 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 288681014141 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681014142 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 288681014143 Walker A/P-loop; other site 288681014144 ATP binding site [chemical binding]; other site 288681014145 Q-loop/lid; other site 288681014146 ABC transporter signature motif; other site 288681014147 Walker B; other site 288681014148 D-loop; other site 288681014149 H-loop/switch region; other site 288681014150 Protein of unknown function (DUF3767); Region: DUF3767; pfam12597 288681014151 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288681014152 protein binding site [polypeptide binding]; other site 288681014153 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 288681014154 C-terminal peptidase (prc); Region: prc; TIGR00225 288681014155 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 288681014156 protein binding site [polypeptide binding]; other site 288681014157 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 288681014158 Catalytic dyad [active] 288681014159 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 288681014160 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 288681014161 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 288681014162 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 288681014163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681014164 Walker A/P-loop; other site 288681014165 ATP binding site [chemical binding]; other site 288681014166 Q-loop/lid; other site 288681014167 ABC transporter signature motif; other site 288681014168 Walker B; other site 288681014169 D-loop; other site 288681014170 H-loop/switch region; other site 288681014171 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 288681014172 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 288681014173 peptide chain release factor 2; Provisional; Region: PRK06746 288681014174 This domain is found in peptide chain release factors; Region: PCRF; smart00937 288681014175 RF-1 domain; Region: RF-1; pfam00472 288681014176 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 288681014177 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 288681014178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 288681014179 nucleotide binding region [chemical binding]; other site 288681014180 ATP-binding site [chemical binding]; other site 288681014181 SEC-C motif; Region: SEC-C; pfam02810 288681014182 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 288681014183 30S subunit binding site; other site 288681014184 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 288681014185 DNA-binding site [nucleotide binding]; DNA binding site 288681014186 RNA-binding motif; other site 288681014187 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 288681014188 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681014189 active site 288681014190 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 288681014191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681014192 ATP binding site [chemical binding]; other site 288681014193 putative Mg++ binding site [ion binding]; other site 288681014194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681014195 nucleotide binding region [chemical binding]; other site 288681014196 ATP-binding site [chemical binding]; other site 288681014197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 288681014198 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288681014199 NlpC/P60 family; Region: NLPC_P60; pfam00877 288681014200 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681014201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681014202 dimerization interface [polypeptide binding]; other site 288681014203 putative DNA binding site [nucleotide binding]; other site 288681014204 putative Zn2+ binding site [ion binding]; other site 288681014205 EDD domain protein, DegV family; Region: DegV; TIGR00762 288681014206 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 288681014207 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 288681014208 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 288681014209 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 288681014210 Transcriptional regulator [Transcription]; Region: LytR; COG1316 288681014211 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 288681014212 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 288681014213 active site 288681014214 homodimer interface [polypeptide binding]; other site 288681014215 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 288681014216 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 288681014217 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288681014218 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 288681014219 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 288681014220 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 288681014221 Mg++ binding site [ion binding]; other site 288681014222 putative catalytic motif [active] 288681014223 substrate binding site [chemical binding]; other site 288681014224 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681014225 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681014226 NodB motif; other site 288681014227 active site 288681014228 catalytic site [active] 288681014229 Zn binding site [ion binding]; other site 288681014230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681014231 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681014232 Walker A motif; other site 288681014233 ATP binding site [chemical binding]; other site 288681014234 Walker B motif; other site 288681014235 arginine finger; other site 288681014236 Transcriptional antiterminator [Transcription]; Region: COG3933 288681014237 PRD domain; Region: PRD; pfam00874 288681014238 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 288681014239 active pocket/dimerization site; other site 288681014240 active site 288681014241 phosphorylation site [posttranslational modification] 288681014242 PRD domain; Region: PRD; pfam00874 288681014243 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 288681014244 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 288681014245 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 288681014246 Chromate transporter; Region: Chromate_transp; pfam02417 288681014247 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 288681014248 putative active site [active] 288681014249 YdjC motif; other site 288681014250 Mg binding site [ion binding]; other site 288681014251 putative homodimer interface [polypeptide binding]; other site 288681014252 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 288681014253 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 288681014254 NAD binding site [chemical binding]; other site 288681014255 sugar binding site [chemical binding]; other site 288681014256 divalent metal binding site [ion binding]; other site 288681014257 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681014258 dimer interface [polypeptide binding]; other site 288681014259 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 288681014260 active site 288681014261 methionine cluster; other site 288681014262 phosphorylation site [posttranslational modification] 288681014263 metal binding site [ion binding]; metal-binding site 288681014264 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681014265 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 288681014266 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681014267 active site 288681014268 P-loop; other site 288681014269 phosphorylation site [posttranslational modification] 288681014270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681014271 S-adenosylmethionine binding site [chemical binding]; other site 288681014272 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 288681014273 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 288681014274 methionine cluster; other site 288681014275 active site 288681014276 phosphorylation site [posttranslational modification] 288681014277 metal binding site [ion binding]; metal-binding site 288681014278 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 288681014279 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 288681014280 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 288681014281 active site 288681014282 P-loop; other site 288681014283 phosphorylation site [posttranslational modification] 288681014284 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 288681014285 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 288681014286 Acyltransferase family; Region: Acyl_transf_3; pfam01757 288681014287 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 288681014288 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681014289 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 288681014290 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 288681014291 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 288681014292 Predicted membrane protein [Function unknown]; Region: COG1511 288681014293 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 288681014294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 288681014295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 288681014296 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 288681014297 putative dimerization interface [polypeptide binding]; other site 288681014298 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 288681014299 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 288681014300 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 288681014301 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 288681014302 transmembrane helices; other site 288681014303 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 288681014304 ThiC-associated domain; Region: ThiC-associated; pfam13667 288681014305 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 288681014306 L-lactate permease; Region: Lactate_perm; cl00701 288681014307 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 288681014308 Transposase; Region: DDE_Tnp_ISL3; pfam01610 288681014309 L-lactate permease; Region: Lactate_perm; cl00701 288681014310 Tic20-like protein; Region: Tic20; pfam09685 288681014311 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 288681014312 Uncharacterized conserved protein [Function unknown]; Region: COG3339 288681014313 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 288681014314 Sulfatase; Region: Sulfatase; pfam00884 288681014315 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 288681014316 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 288681014317 homodimer interface [polypeptide binding]; other site 288681014318 substrate-cofactor binding pocket; other site 288681014319 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681014320 catalytic residue [active] 288681014321 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014322 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014323 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014324 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014325 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014326 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288681014327 NlpC/P60 family; Region: NLPC_P60; pfam00877 288681014328 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 288681014329 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 288681014330 Nucleoside recognition; Region: Gate; pfam07670 288681014331 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 288681014332 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 288681014333 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 288681014334 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 288681014335 DXD motif; other site 288681014336 BCCT family transporter; Region: BCCT; pfam02028 288681014337 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014338 Bacterial SH3 domain; Region: SH3_3; pfam08239 288681014339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 288681014340 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 288681014341 Predicted membrane protein [Function unknown]; Region: COG4640 288681014342 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 288681014343 Double zinc ribbon; Region: DZR; pfam12773 288681014344 Double zinc ribbon; Region: DZR; pfam12773 288681014345 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 288681014346 SNF2 Helicase protein; Region: DUF3670; pfam12419 288681014347 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 288681014348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 288681014349 ATP binding site [chemical binding]; other site 288681014350 putative Mg++ binding site [ion binding]; other site 288681014351 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 288681014352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681014353 nucleotide binding region [chemical binding]; other site 288681014354 ATP-binding site [chemical binding]; other site 288681014355 Predicted integral membrane protein [Function unknown]; Region: COG5652 288681014356 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 288681014357 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 288681014358 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 288681014359 ComK protein; Region: ComK; pfam06338 288681014360 RNA polymerase factor sigma-70; Validated; Region: PRK06759 288681014361 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681014362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681014363 DNA binding residues [nucleotide binding] 288681014364 Yip1 domain; Region: Yip1; cl17815 288681014365 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 288681014366 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 288681014367 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681014368 FtsX-like permease family; Region: FtsX; pfam02687 288681014369 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681014370 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681014371 Walker A/P-loop; other site 288681014372 ATP binding site [chemical binding]; other site 288681014373 Q-loop/lid; other site 288681014374 ABC transporter signature motif; other site 288681014375 Walker B; other site 288681014376 D-loop; other site 288681014377 H-loop/switch region; other site 288681014378 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 288681014379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 288681014380 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681014381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681014382 non-specific DNA binding site [nucleotide binding]; other site 288681014383 salt bridge; other site 288681014384 sequence-specific DNA binding site [nucleotide binding]; other site 288681014385 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 288681014386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014387 putative substrate translocation pore; other site 288681014388 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 288681014389 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 288681014390 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 288681014391 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 288681014392 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681014393 dimerization interface [polypeptide binding]; other site 288681014394 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681014395 dimer interface [polypeptide binding]; other site 288681014396 phosphorylation site [posttranslational modification] 288681014397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681014398 ATP binding site [chemical binding]; other site 288681014399 Mg2+ binding site [ion binding]; other site 288681014400 G-X-G motif; other site 288681014401 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681014402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014403 active site 288681014404 phosphorylation site [posttranslational modification] 288681014405 intermolecular recognition site; other site 288681014406 dimerization interface [polypeptide binding]; other site 288681014407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681014408 DNA binding site [nucleotide binding] 288681014409 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 288681014410 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 288681014411 NAD binding site [chemical binding]; other site 288681014412 homodimer interface [polypeptide binding]; other site 288681014413 active site 288681014414 substrate binding site [chemical binding]; other site 288681014415 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 288681014416 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 288681014417 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 288681014418 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 288681014419 active site 288681014420 homodimer interface [polypeptide binding]; other site 288681014421 teichoic acids export protein ATP-binding subunit; Provisional; Region: tagH; PRK13545 288681014422 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 288681014423 Walker A/P-loop; other site 288681014424 ATP binding site [chemical binding]; other site 288681014425 Q-loop/lid; other site 288681014426 ABC transporter signature motif; other site 288681014427 Walker B; other site 288681014428 D-loop; other site 288681014429 H-loop/switch region; other site 288681014430 Bacterial SH3 domain homologues; Region: SH3b; smart00287 288681014431 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 288681014432 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 288681014433 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 288681014434 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 288681014435 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 288681014436 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 288681014437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681014438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681014439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 288681014440 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 288681014441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681014442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681014443 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681014444 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 288681014445 rod shape-determining protein Mbl; Provisional; Region: PRK13928 288681014446 MreB and similar proteins; Region: MreB_like; cd10225 288681014447 nucleotide binding site [chemical binding]; other site 288681014448 Mg binding site [ion binding]; other site 288681014449 putative protofilament interaction site [polypeptide binding]; other site 288681014450 RodZ interaction site [polypeptide binding]; other site 288681014451 Stage III sporulation protein D; Region: SpoIIID; pfam12116 288681014452 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 288681014453 putative active site [active] 288681014454 putative metal binding site [ion binding]; other site 288681014455 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 288681014456 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 288681014457 active site 288681014458 CoA binding site [chemical binding]; other site 288681014459 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 288681014460 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681014461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 288681014462 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 288681014463 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 288681014464 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 288681014465 Peptidase family M23; Region: Peptidase_M23; pfam01551 288681014466 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 288681014467 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 288681014468 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681014469 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681014470 Walker A/P-loop; other site 288681014471 ATP binding site [chemical binding]; other site 288681014472 Q-loop/lid; other site 288681014473 ABC transporter signature motif; other site 288681014474 Walker B; other site 288681014475 D-loop; other site 288681014476 H-loop/switch region; other site 288681014477 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 288681014478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681014479 Walker A/P-loop; other site 288681014480 ATP binding site [chemical binding]; other site 288681014481 Q-loop/lid; other site 288681014482 ABC transporter signature motif; other site 288681014483 Walker B; other site 288681014484 D-loop; other site 288681014485 H-loop/switch region; other site 288681014486 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681014487 LytTr DNA-binding domain; Region: LytTR; pfam04397 288681014488 Stage II sporulation protein; Region: SpoIID; pfam08486 288681014489 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 288681014490 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 288681014491 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 288681014492 hinge; other site 288681014493 active site 288681014494 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 288681014495 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 288681014496 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 288681014497 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 288681014498 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 288681014499 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 288681014500 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 288681014501 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 288681014502 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 288681014503 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 288681014504 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 288681014505 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 288681014506 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 288681014507 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 288681014508 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 288681014509 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 288681014510 NADH dehydrogenase subunit C; Validated; Region: PRK07735 288681014511 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 288681014512 NADH dehydrogenase subunit B; Validated; Region: PRK06411 288681014513 NADH dehydrogenase subunit A; Validated; Region: PRK07756 288681014514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681014515 PAS domain; Region: PAS_9; pfam13426 288681014516 putative active site [active] 288681014517 heme pocket [chemical binding]; other site 288681014518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681014519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681014520 metal binding site [ion binding]; metal-binding site 288681014521 active site 288681014522 I-site; other site 288681014523 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681014524 Protein of unknown function (DUF975); Region: DUF975; cl10504 288681014525 Protein of unknown function (DUF975); Region: DUF975; cl10504 288681014526 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 288681014527 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 288681014528 gamma subunit interface [polypeptide binding]; other site 288681014529 epsilon subunit interface [polypeptide binding]; other site 288681014530 LBP interface [polypeptide binding]; other site 288681014531 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 288681014532 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 288681014533 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 288681014534 alpha subunit interaction interface [polypeptide binding]; other site 288681014535 Walker A motif; other site 288681014536 ATP binding site [chemical binding]; other site 288681014537 Walker B motif; other site 288681014538 inhibitor binding site; inhibition site 288681014539 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 288681014540 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 288681014541 core domain interface [polypeptide binding]; other site 288681014542 delta subunit interface [polypeptide binding]; other site 288681014543 epsilon subunit interface [polypeptide binding]; other site 288681014544 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 288681014545 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 288681014546 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 288681014547 beta subunit interaction interface [polypeptide binding]; other site 288681014548 Walker A motif; other site 288681014549 ATP binding site [chemical binding]; other site 288681014550 Walker B motif; other site 288681014551 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 288681014552 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 288681014553 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 288681014554 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 288681014555 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 288681014556 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 288681014557 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 288681014558 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 288681014559 ATP synthase I chain; Region: ATP_synt_I; pfam03899 288681014560 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 288681014561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 288681014562 active site 288681014563 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 288681014564 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 288681014565 dimer interface [polypeptide binding]; other site 288681014566 active site 288681014567 glycine-pyridoxal phosphate binding site [chemical binding]; other site 288681014568 folate binding site [chemical binding]; other site 288681014569 hypothetical protein; Provisional; Region: PRK13690 288681014570 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 288681014571 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 288681014572 Low molecular weight phosphatase family; Region: LMWPc; cd00115 288681014573 active site 288681014574 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 288681014575 HPr interaction site; other site 288681014576 glycerol kinase (GK) interaction site [polypeptide binding]; other site 288681014577 active site 288681014578 phosphorylation site [posttranslational modification] 288681014579 Predicted membrane protein [Function unknown]; Region: COG2259 288681014580 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 288681014581 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 288681014582 oligomer interface [polypeptide binding]; other site 288681014583 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 288681014584 Predicted membrane protein [Function unknown]; Region: COG1971 288681014585 Domain of unknown function DUF; Region: DUF204; pfam02659 288681014586 Domain of unknown function DUF; Region: DUF204; pfam02659 288681014587 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 288681014588 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 288681014589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 288681014590 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 288681014591 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 288681014592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681014593 S-adenosylmethionine binding site [chemical binding]; other site 288681014594 peptide chain release factor 1; Validated; Region: prfA; PRK00591 288681014595 This domain is found in peptide chain release factors; Region: PCRF; smart00937 288681014596 RF-1 domain; Region: RF-1; pfam00472 288681014597 thymidine kinase; Provisional; Region: PRK04296 288681014598 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 288681014599 transcription termination factor Rho; Provisional; Region: rho; PRK09376 288681014600 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 288681014601 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 288681014602 RNA binding site [nucleotide binding]; other site 288681014603 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 288681014604 multimer interface [polypeptide binding]; other site 288681014605 Walker A motif; other site 288681014606 ATP binding site [chemical binding]; other site 288681014607 Walker B motif; other site 288681014608 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 288681014609 putative active site [active] 288681014610 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 288681014611 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 288681014612 hinge; other site 288681014613 active site 288681014614 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 288681014615 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681014616 intersubunit interface [polypeptide binding]; other site 288681014617 active site 288681014618 zinc binding site [ion binding]; other site 288681014619 Na+ binding site [ion binding]; other site 288681014620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014621 active site 288681014622 phosphorylation site [posttranslational modification] 288681014623 intermolecular recognition site; other site 288681014624 dimerization interface [polypeptide binding]; other site 288681014625 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 288681014626 CTP synthetase; Validated; Region: pyrG; PRK05380 288681014627 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 288681014628 Catalytic site [active] 288681014629 active site 288681014630 UTP binding site [chemical binding]; other site 288681014631 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 288681014632 active site 288681014633 putative oxyanion hole; other site 288681014634 catalytic triad [active] 288681014635 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 288681014636 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681014637 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681014638 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681014639 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 288681014640 FAD binding site [chemical binding]; other site 288681014641 homotetramer interface [polypeptide binding]; other site 288681014642 substrate binding pocket [chemical binding]; other site 288681014643 catalytic base [active] 288681014644 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 288681014645 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 288681014646 FAD binding site [chemical binding]; other site 288681014647 homotetramer interface [polypeptide binding]; other site 288681014648 substrate binding pocket [chemical binding]; other site 288681014649 catalytic base [active] 288681014650 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 288681014651 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288681014652 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681014653 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 288681014654 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 288681014655 dimer interface [polypeptide binding]; other site 288681014656 active site 288681014657 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 288681014658 4Fe-4S binding domain; Region: Fer4; cl02805 288681014659 Cysteine-rich domain; Region: CCG; pfam02754 288681014660 Cysteine-rich domain; Region: CCG; pfam02754 288681014661 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 288681014662 PLD-like domain; Region: PLDc_2; pfam13091 288681014663 putative active site [active] 288681014664 catalytic site [active] 288681014665 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 288681014666 PLD-like domain; Region: PLDc_2; pfam13091 288681014667 putative active site [active] 288681014668 catalytic site [active] 288681014669 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 288681014670 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 288681014671 PAS domain S-box; Region: sensory_box; TIGR00229 288681014672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681014673 putative active site [active] 288681014674 heme pocket [chemical binding]; other site 288681014675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681014676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681014677 metal binding site [ion binding]; metal-binding site 288681014678 active site 288681014679 I-site; other site 288681014680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 288681014681 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 288681014682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681014683 non-specific DNA binding site [nucleotide binding]; other site 288681014684 salt bridge; other site 288681014685 sequence-specific DNA binding site [nucleotide binding]; other site 288681014686 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681014687 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681014688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014689 active site 288681014690 phosphorylation site [posttranslational modification] 288681014691 intermolecular recognition site; other site 288681014692 dimerization interface [polypeptide binding]; other site 288681014693 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681014694 DNA binding residues [nucleotide binding] 288681014695 dimerization interface [polypeptide binding]; other site 288681014696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681014697 Q-cell neuroblast polarisation; Region: Dpy19; pfam10034 288681014698 Histidine kinase; Region: HisKA_3; pfam07730 288681014699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681014700 ATP binding site [chemical binding]; other site 288681014701 Mg2+ binding site [ion binding]; other site 288681014702 G-X-G motif; other site 288681014703 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 288681014704 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 288681014705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681014706 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 288681014707 Walker A/P-loop; other site 288681014708 ATP binding site [chemical binding]; other site 288681014709 Q-loop/lid; other site 288681014710 ABC transporter signature motif; other site 288681014711 Walker B; other site 288681014712 D-loop; other site 288681014713 H-loop/switch region; other site 288681014714 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 288681014715 active site 288681014716 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 288681014717 Collagen binding domain; Region: Collagen_bind; pfam05737 288681014718 Collagen binding domain; Region: Collagen_bind; pfam05737 288681014719 Collagen binding domain; Region: Collagen_bind; pfam05737 288681014720 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014721 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014722 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014723 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014724 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014725 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014726 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014727 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 288681014728 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014729 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014730 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014731 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014732 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014733 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014734 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 288681014735 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014736 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014737 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014738 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014739 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014740 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 288681014741 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014742 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014743 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014744 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014745 Cna protein B-type domain; Region: Cna_B; pfam05738 288681014746 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 288681014747 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 288681014748 PA/protease or protease-like domain interface [polypeptide binding]; other site 288681014749 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 288681014750 Peptidase family M28; Region: Peptidase_M28; pfam04389 288681014751 metal binding site [ion binding]; metal-binding site 288681014752 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 288681014753 5'-adenylylsulfate reductase; Region: PLN02309 288681014754 RNA polymerase sigma factor; Provisional; Region: PRK12522 288681014755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681014756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681014757 DNA binding residues [nucleotide binding] 288681014758 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 288681014759 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 288681014760 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 288681014761 active site 288681014762 HIGH motif; other site 288681014763 KMSK motif region; other site 288681014764 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 288681014765 tRNA binding surface [nucleotide binding]; other site 288681014766 anticodon binding site; other site 288681014767 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 288681014768 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681014769 putative dimer interface [polypeptide binding]; other site 288681014770 catalytic triad [active] 288681014771 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 288681014772 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 288681014773 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 288681014774 agmatinase; Region: agmatinase; TIGR01230 288681014775 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 288681014776 putative active site [active] 288681014777 Mn binding site [ion binding]; other site 288681014778 spermidine synthase; Provisional; Region: PRK00811 288681014779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681014780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681014782 putative substrate translocation pore; other site 288681014783 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681014784 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 288681014785 DNA binding residues [nucleotide binding] 288681014786 putative dimer interface [polypeptide binding]; other site 288681014787 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 288681014788 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 288681014789 active site 288681014790 catalytic site [active] 288681014791 metal binding site [ion binding]; metal-binding site 288681014792 dimer interface [polypeptide binding]; other site 288681014793 Transglycosylase; Region: Transgly; pfam00912 288681014794 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 288681014795 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 288681014796 YwhD family; Region: YwhD; pfam08741 288681014797 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 288681014798 Peptidase family M50; Region: Peptidase_M50; pfam02163 288681014799 active site 288681014800 putative substrate binding region [chemical binding]; other site 288681014801 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 288681014802 active site 1 [active] 288681014803 dimer interface [polypeptide binding]; other site 288681014804 hexamer interface [polypeptide binding]; other site 288681014805 active site 2 [active] 288681014806 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 288681014807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 288681014808 Zn2+ binding site [ion binding]; other site 288681014809 Mg2+ binding site [ion binding]; other site 288681014810 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 288681014811 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 288681014812 intersubunit interface [polypeptide binding]; other site 288681014813 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 288681014814 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 288681014815 Walker A/P-loop; other site 288681014816 ATP binding site [chemical binding]; other site 288681014817 Q-loop/lid; other site 288681014818 ABC transporter signature motif; other site 288681014819 Walker B; other site 288681014820 D-loop; other site 288681014821 H-loop/switch region; other site 288681014822 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681014823 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681014824 ABC-ATPase subunit interface; other site 288681014825 dimer interface [polypeptide binding]; other site 288681014826 putative PBP binding regions; other site 288681014827 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 288681014828 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681014829 ABC-ATPase subunit interface; other site 288681014830 dimer interface [polypeptide binding]; other site 288681014831 putative PBP binding regions; other site 288681014832 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 288681014833 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 288681014834 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 288681014835 hypothetical protein; Provisional; Region: PRK12473 288681014836 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 288681014837 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 288681014838 putative heme peroxidase; Provisional; Region: PRK12276 288681014839 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 288681014840 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 288681014841 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 288681014842 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 288681014843 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681014844 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 288681014845 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 288681014846 Ion channel; Region: Ion_trans_2; pfam07885 288681014847 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 288681014848 TrkA-N domain; Region: TrkA_N; pfam02254 288681014849 TrkA-C domain; Region: TrkA_C; pfam02080 288681014850 putative uracil/xanthine transporter; Provisional; Region: PRK11412 288681014851 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 288681014852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014853 motif II; other site 288681014854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014855 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 288681014856 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 288681014857 ligand binding site [chemical binding]; other site 288681014858 active site 288681014859 UGI interface [polypeptide binding]; other site 288681014860 catalytic site [active] 288681014861 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 288681014862 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 288681014863 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 288681014864 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 288681014865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 288681014866 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 288681014867 Walker A/P-loop; other site 288681014868 ATP binding site [chemical binding]; other site 288681014869 Q-loop/lid; other site 288681014870 ABC transporter signature motif; other site 288681014871 Walker B; other site 288681014872 D-loop; other site 288681014873 H-loop/switch region; other site 288681014874 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 288681014875 active site 288681014876 catalytic triad [active] 288681014877 oxyanion hole [active] 288681014878 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681014879 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681014880 DNA binding site [nucleotide binding] 288681014881 domain linker motif; other site 288681014882 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 288681014883 putative dimerization interface [polypeptide binding]; other site 288681014884 putative ligand binding site [chemical binding]; other site 288681014885 Predicted membrane protein [Function unknown]; Region: COG2364 288681014886 homoserine dehydrogenase; Provisional; Region: PRK06349 288681014887 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 288681014888 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 288681014889 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 288681014890 homoserine O-succinyltransferase; Provisional; Region: PRK05368 288681014891 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 288681014892 proposed active site lysine [active] 288681014893 conserved cys residue [active] 288681014894 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 288681014895 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 288681014896 homodimer interface [polypeptide binding]; other site 288681014897 substrate-cofactor binding pocket; other site 288681014898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681014899 catalytic residue [active] 288681014900 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 288681014901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681014902 active site 288681014903 motif I; other site 288681014904 motif II; other site 288681014905 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 288681014906 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 288681014907 ligand binding site [chemical binding]; other site 288681014908 flexible hinge region; other site 288681014909 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 288681014910 azoreductase; Provisional; Region: PRK13556 288681014911 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 288681014912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014913 active site 288681014914 phosphorylation site [posttranslational modification] 288681014915 intermolecular recognition site; other site 288681014916 dimerization interface [polypeptide binding]; other site 288681014917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 288681014918 DNA binding residues [nucleotide binding] 288681014919 dimerization interface [polypeptide binding]; other site 288681014920 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 288681014921 GAF domain; Region: GAF; pfam01590 288681014922 GAF domain; Region: GAF_3; pfam13492 288681014923 GAF domain; Region: GAF_2; pfam13185 288681014924 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 288681014925 Histidine kinase; Region: HisKA_3; pfam07730 288681014926 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 288681014927 ATP binding site [chemical binding]; other site 288681014928 Mg2+ binding site [ion binding]; other site 288681014929 G-X-G motif; other site 288681014930 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 288681014931 dimer interface [polypeptide binding]; other site 288681014932 substrate binding site [chemical binding]; other site 288681014933 ATP binding site [chemical binding]; other site 288681014934 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 288681014935 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 288681014936 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 288681014937 metal binding site [ion binding]; metal-binding site 288681014938 active site 288681014939 I-site; other site 288681014940 Protein of unknown function (DUF466); Region: DUF466; pfam04328 288681014941 carbon starvation protein A; Provisional; Region: PRK15015 288681014942 Carbon starvation protein CstA; Region: CstA; pfam02554 288681014943 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 288681014944 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 288681014945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014946 active site 288681014947 phosphorylation site [posttranslational modification] 288681014948 intermolecular recognition site; other site 288681014949 dimerization interface [polypeptide binding]; other site 288681014950 LytTr DNA-binding domain; Region: LytTR; pfam04397 288681014951 benzoate transport; Region: 2A0115; TIGR00895 288681014952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681014953 putative substrate translocation pore; other site 288681014954 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 288681014955 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 288681014956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 288681014957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 288681014958 Predicted membrane protein [Function unknown]; Region: COG2860 288681014959 UPF0126 domain; Region: UPF0126; pfam03458 288681014960 UPF0126 domain; Region: UPF0126; pfam03458 288681014961 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 288681014962 heme-binding site [chemical binding]; other site 288681014963 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681014964 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681014965 dimer interface [polypeptide binding]; other site 288681014966 putative CheW interface [polypeptide binding]; other site 288681014967 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 288681014968 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 288681014969 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 288681014970 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 288681014971 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 288681014972 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 288681014973 active site 288681014974 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 288681014975 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681014976 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681014977 ABC transporter; Region: ABC_tran_2; pfam12848 288681014978 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 288681014979 conserved hypothetical integral membrane protein; Region: TIGR03766 288681014980 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 288681014981 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 288681014982 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 288681014983 Ligand binding site; other site 288681014984 Putative Catalytic site; other site 288681014985 DXD motif; other site 288681014986 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681014987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681014988 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 288681014989 Protein export membrane protein; Region: SecD_SecF; cl14618 288681014990 methionine sulfoxide reductase A; Provisional; Region: PRK14054 288681014991 methionine sulfoxide reductase B; Provisional; Region: PRK00222 288681014992 SelR domain; Region: SelR; pfam01641 288681014993 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 288681014994 antiholin-like protein LrgB; Provisional; Region: PRK04288 288681014995 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 288681014996 two-component response regulator; Provisional; Region: PRK14084 288681014997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681014998 active site 288681014999 phosphorylation site [posttranslational modification] 288681015000 intermolecular recognition site; other site 288681015001 dimerization interface [polypeptide binding]; other site 288681015002 LytTr DNA-binding domain; Region: LytTR; pfam04397 288681015003 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 288681015004 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 288681015005 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 288681015006 Histidine kinase; Region: His_kinase; pfam06580 288681015007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681015008 ATP binding site [chemical binding]; other site 288681015009 Mg2+ binding site [ion binding]; other site 288681015010 G-X-G motif; other site 288681015011 benzoate transport; Region: 2A0115; TIGR00895 288681015012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015013 putative substrate translocation pore; other site 288681015014 BCCT family transporter; Region: BCCT; pfam02028 288681015015 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cl00254 288681015016 active site 288681015017 dimer interface [polypeptide binding]; other site 288681015018 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 288681015019 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 288681015020 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 288681015021 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 288681015022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 288681015023 NAD(P) binding site [chemical binding]; other site 288681015024 active site 288681015025 UreI/AmiS family, subgroup 2. Putative transporters related to proton-gated urea channel and putative amide transporters; Region: UreI_AmiS_like_2; cd13429 288681015026 hexamer interface [polypeptide binding]; other site 288681015027 transport channel [chemical binding]; other site 288681015028 constriction site 1 [chemical binding]; other site 288681015029 constriction site 2 [chemical binding]; other site 288681015030 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 288681015031 UDP-glucose 4-epimerase; Region: PLN02240 288681015032 NAD binding site [chemical binding]; other site 288681015033 homodimer interface [polypeptide binding]; other site 288681015034 active site 288681015035 substrate binding site [chemical binding]; other site 288681015036 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 288681015037 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 288681015038 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 288681015039 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 288681015040 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 288681015041 ATP binding site [chemical binding]; other site 288681015042 Mg++ binding site [ion binding]; other site 288681015043 motif III; other site 288681015044 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 288681015045 nucleotide binding region [chemical binding]; other site 288681015046 ATP-binding site [chemical binding]; other site 288681015047 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 288681015048 RNA binding site [nucleotide binding]; other site 288681015049 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 288681015050 Acyltransferase family; Region: Acyl_transf_3; pfam01757 288681015051 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 288681015052 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 288681015053 active site 288681015054 oligoendopeptidase F; Region: pepF; TIGR00181 288681015055 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 288681015056 active site 288681015057 Zn binding site [ion binding]; other site 288681015058 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 288681015059 FeS/SAM binding site; other site 288681015060 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 288681015061 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 288681015062 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 288681015063 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 288681015064 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 288681015065 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 288681015066 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 288681015067 protein binding site [polypeptide binding]; other site 288681015068 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 288681015069 YycH protein; Region: YycI; pfam09648 288681015070 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 288681015071 YycH protein; Region: YycH; pfam07435 288681015072 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 288681015073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 288681015074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681015075 dimerization interface [polypeptide binding]; other site 288681015076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681015077 putative active site [active] 288681015078 heme pocket [chemical binding]; other site 288681015079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 288681015080 dimer interface [polypeptide binding]; other site 288681015081 phosphorylation site [posttranslational modification] 288681015082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 288681015083 ATP binding site [chemical binding]; other site 288681015084 Mg2+ binding site [ion binding]; other site 288681015085 G-X-G motif; other site 288681015086 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681015087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681015088 active site 288681015089 phosphorylation site [posttranslational modification] 288681015090 intermolecular recognition site; other site 288681015091 dimerization interface [polypeptide binding]; other site 288681015092 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681015093 DNA binding site [nucleotide binding] 288681015094 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 288681015095 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 288681015096 GDP-binding site [chemical binding]; other site 288681015097 ACT binding site; other site 288681015098 IMP binding site; other site 288681015099 replicative DNA helicase; Provisional; Region: PRK05748 288681015100 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 288681015101 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 288681015102 Walker A motif; other site 288681015103 ATP binding site [chemical binding]; other site 288681015104 Walker B motif; other site 288681015105 DNA binding loops [nucleotide binding] 288681015106 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 288681015107 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 288681015108 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 288681015109 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 288681015110 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 288681015111 DHH family; Region: DHH; pfam01368 288681015112 DHHA1 domain; Region: DHHA1; pfam02272 288681015113 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 288681015114 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 288681015115 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 288681015116 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 288681015117 dimer interface [polypeptide binding]; other site 288681015118 ssDNA binding site [nucleotide binding]; other site 288681015119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 288681015120 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 288681015121 GTP-binding protein YchF; Reviewed; Region: PRK09601 288681015122 YchF GTPase; Region: YchF; cd01900 288681015123 G1 box; other site 288681015124 GTP/Mg2+ binding site [chemical binding]; other site 288681015125 Switch I region; other site 288681015126 G2 box; other site 288681015127 Switch II region; other site 288681015128 G3 box; other site 288681015129 G4 box; other site 288681015130 G5 box; other site 288681015131 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 288681015132 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 288681015133 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 288681015134 Mechanosensitive ion channel; Region: MS_channel; pfam00924 288681015135 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 288681015136 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 288681015137 ParB-like nuclease domain; Region: ParBc; pfam02195 288681015138 KorB domain; Region: KorB; pfam08535 288681015139 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 288681015140 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681015141 P-loop; other site 288681015142 Magnesium ion binding site [ion binding]; other site 288681015143 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681015144 Magnesium ion binding site [ion binding]; other site 288681015145 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 288681015146 ParB-like nuclease domain; Region: ParBc; pfam02195 288681015147 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 288681015148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681015149 S-adenosylmethionine binding site [chemical binding]; other site 288681015150 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 288681015151 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 288681015152 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 288681015153 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 288681015154 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 288681015155 trmE is a tRNA modification GTPase; Region: trmE; cd04164 288681015156 G1 box; other site 288681015157 GTP/Mg2+ binding site [chemical binding]; other site 288681015158 Switch I region; other site 288681015159 G2 box; other site 288681015160 Switch II region; other site 288681015161 G3 box; other site 288681015162 G4 box; other site 288681015163 G5 box; other site 288681015164 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 288681015165 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 288681015166 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 288681015167 G-X-X-G motif; other site 288681015168 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 288681015169 RxxxH motif; other site 288681015170 OxaA-like protein precursor; Validated; Region: PRK02944 288681015171 ribonuclease P; Reviewed; Region: rnpA; PRK00499 288681015172 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 288681015173 exosporium leader peptide; Region: exospor_lead; TIGR03720 288681015174 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681015175 Resolvase, N terminal domain; Region: Resolvase; pfam00239 288681015176 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681015177 DNA-binding interface [nucleotide binding]; DNA binding site 288681015178 DNA primase domain-containing protein; Region: PHA02415 288681015179 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015180 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 288681015181 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 288681015182 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 288681015183 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 288681015184 active site 288681015185 catalytic site [active] 288681015186 substrate binding site [chemical binding]; other site 288681015187 Tar ligand binding domain homologue; Region: TarH; pfam02203 288681015188 Cache domain; Region: Cache_1; pfam02743 288681015189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681015190 dimerization interface [polypeptide binding]; other site 288681015191 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 288681015192 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681015193 dimer interface [polypeptide binding]; other site 288681015194 putative CheW interface [polypeptide binding]; other site 288681015195 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 288681015196 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 288681015197 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015198 active site 288681015199 DNA binding site [nucleotide binding] 288681015200 Int/Topo IB signature motif; other site 288681015201 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 288681015202 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 288681015203 catalytic residues [active] 288681015204 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 288681015205 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 288681015206 putative active site [active] 288681015207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 288681015208 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 288681015209 Walker A/P-loop; other site 288681015210 ATP binding site [chemical binding]; other site 288681015211 Q-loop/lid; other site 288681015212 ABC transporter signature motif; other site 288681015213 Walker B; other site 288681015214 D-loop; other site 288681015215 H-loop/switch region; other site 288681015216 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681015217 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681015218 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681015219 glycopeptide, sublancin family; Region: glycopep_SunS; TIGR04196 288681015220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 288681015221 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 288681015222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 288681015223 dimer interface [polypeptide binding]; other site 288681015224 conserved gate region; other site 288681015225 ABC-ATPase subunit interface; other site 288681015226 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 288681015227 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 288681015228 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 288681015229 similar to transposase 288681015230 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015231 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 288681015232 active site 288681015233 DNA binding site [nucleotide binding] 288681015234 Int/Topo IB signature motif; other site 288681015235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015237 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015238 Probable transposase; Region: OrfB_IS605; pfam01385 288681015239 nonfunctional sodium/proline symporter family protein 288681015240 BCCT family transporter; Region: BCCT; pfam02028 288681015241 Integrase core domain; Region: rve; pfam00665 288681015242 Integrase core domain; Region: rve_2; pfam13333 288681015243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681015244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681015245 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 288681015246 similar to transposase 288681015247 Probable transposase; Region: OrfB_IS605; pfam01385 288681015248 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015249 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015250 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 288681015251 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015252 active site 288681015253 DNA binding site [nucleotide binding] 288681015254 Int/Topo IB signature motif; other site 288681015255 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015256 DNA binding residues [nucleotide binding] 288681015257 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 288681015258 DNA binding residues [nucleotide binding] 288681015259 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 288681015260 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015261 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681015262 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681015263 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015264 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015265 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 288681015266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 288681015267 Coenzyme A binding pocket [chemical binding]; other site 288681015268 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 288681015269 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 288681015270 Walker A/P-loop; other site 288681015271 ATP binding site [chemical binding]; other site 288681015272 Q-loop/lid; other site 288681015273 ABC transporter signature motif; other site 288681015274 Walker B; other site 288681015275 D-loop; other site 288681015276 H-loop/switch region; other site 288681015277 FtsX-like permease family; Region: FtsX; pfam02687 288681015278 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 288681015279 FtsX-like permease family; Region: FtsX; pfam02687 288681015280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681015282 putative substrate translocation pore; other site 288681015283 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681015284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681015285 multiple promoter invertase; Provisional; Region: mpi; PRK13413 288681015286 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681015287 catalytic residues [active] 288681015288 catalytic nucleophile [active] 288681015289 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681015290 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681015291 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681015292 Synaptic Site I dimer interface [polypeptide binding]; other site 288681015293 DNA binding site [nucleotide binding] 288681015294 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681015295 DNA-binding interface [nucleotide binding]; DNA binding site 288681015296 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 288681015297 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 288681015298 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015299 Uncharacterized ATPase, putative transposase [General function prediction only]; Region: COG2842 288681015300 Helix-turn-helix domain; Region: HTH_28; pfam13518 288681015301 Winged helix-turn helix; Region: HTH_29; pfam13551 288681015302 Homeodomain-like domain; Region: HTH_32; pfam13565 288681015303 Integrase core domain; Region: rve; pfam00665 288681015304 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 288681015305 multiple promoter invertase; Provisional; Region: mpi; PRK13413 288681015306 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681015307 catalytic residues [active] 288681015308 catalytic nucleophile [active] 288681015309 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681015310 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681015311 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681015312 Synaptic Site I dimer interface [polypeptide binding]; other site 288681015313 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681015314 DNA-binding interface [nucleotide binding]; DNA binding site 288681015315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 288681015316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 288681015317 hypothetical protein; Provisional; Region: PRK06185 288681015318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 288681015319 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 288681015320 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015321 S-layer homology domain; Region: SLH; pfam00395 288681015322 S-layer homology domain; Region: SLH; pfam00395 288681015323 S-layer homology domain; Region: SLH; pfam00395 288681015324 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 288681015325 Bacterial SH3 domain; Region: SH3_3; cl17532 288681015326 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681015327 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 288681015328 NodB motif; other site 288681015329 active site 288681015330 Zn binding site [ion binding]; other site 288681015331 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681015332 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681015333 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 288681015334 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 288681015335 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 288681015336 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 288681015337 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 288681015338 EamA-like transporter family; Region: EamA; pfam00892 288681015339 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 288681015340 EamA-like transporter family; Region: EamA; pfam00892 288681015341 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 288681015342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 288681015343 DNA-binding site [nucleotide binding]; DNA binding site 288681015344 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681015345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681015346 homodimer interface [polypeptide binding]; other site 288681015347 catalytic residue [active] 288681015348 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015349 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015350 Probable transposase; Region: OrfB_IS605; pfam01385 288681015351 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015352 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 288681015353 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 288681015354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015355 putative substrate translocation pore; other site 288681015356 POT family; Region: PTR2; pfam00854 288681015357 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 288681015358 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681015359 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681015360 Beta-lactamase; Region: Beta-lactamase; pfam00144 288681015361 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 288681015362 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681015363 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681015364 active site 288681015365 Zn binding site [ion binding]; other site 288681015366 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 288681015367 positive control sigma-like factor; Validated; Region: PRK06930 288681015368 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681015369 DNA binding residues [nucleotide binding] 288681015370 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 288681015371 Recombination protein U; Region: RecU; pfam03838 288681015372 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681015374 dimerization interface [polypeptide binding]; other site 288681015375 putative DNA binding site [nucleotide binding]; other site 288681015376 putative Zn2+ binding site [ion binding]; other site 288681015377 H+ Antiporter protein; Region: 2A0121; TIGR00900 288681015378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015379 putative substrate translocation pore; other site 288681015380 nonfunctional IS231-related transposase 288681015381 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015382 bacterial Hfq-like; Region: Hfq; cd01716 288681015383 hexamer interface [polypeptide binding]; other site 288681015384 Sm1 motif; other site 288681015385 RNA binding site [nucleotide binding]; other site 288681015386 Sm2 motif; other site 288681015387 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681015388 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 288681015389 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 288681015390 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681015391 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681015392 putative active site [active] 288681015393 Predicted membrane protein [Function unknown]; Region: COG2323 288681015394 Probable transposase; Region: OrfB_IS605; pfam01385 288681015395 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 288681015396 transposase fragments 288681015397 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 288681015398 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 288681015399 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 288681015400 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 288681015401 Spore germination protein; Region: Spore_permease; cl17796 288681015402 Spore germination protein; Region: Spore_permease; cl17796 288681015403 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 288681015404 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 288681015405 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 288681015406 Viral enhancin protein; Region: Enhancin; pfam03272 288681015407 Peptidase M60-like family; Region: M60-like; pfam13402 288681015408 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681015409 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 288681015410 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 288681015411 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 288681015412 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 288681015413 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 288681015414 FOG: PKD repeat [General function prediction only]; Region: COG3291 288681015415 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 288681015416 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 288681015417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681015418 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 288681015419 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 288681015420 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 288681015421 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681015422 dimerization interface [polypeptide binding]; other site 288681015423 putative DNA binding site [nucleotide binding]; other site 288681015424 putative Zn2+ binding site [ion binding]; other site 288681015425 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 288681015426 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 288681015427 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 288681015428 catalytic motif [active] 288681015429 Zn binding site [ion binding]; other site 288681015430 RibD C-terminal domain; Region: RibD_C; cl17279 288681015431 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 288681015432 dimerization interface [polypeptide binding]; other site 288681015433 active site 288681015434 Predicted transcriptional regulators [Transcription]; Region: COG1733 288681015435 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 288681015436 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681015437 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681015438 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 288681015439 active site 288681015440 catalytic site [active] 288681015441 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 288681015442 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 288681015443 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015444 non-specific DNA binding site [nucleotide binding]; other site 288681015445 salt bridge; other site 288681015446 sequence-specific DNA binding site [nucleotide binding]; other site 288681015447 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 288681015448 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015449 active site 288681015450 DNA binding site [nucleotide binding] 288681015451 Int/Topo IB signature motif; other site 288681015452 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 288681015453 nonfunctional IS231-related transposases 288681015454 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 288681015455 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 288681015456 DltD N-terminal region; Region: DltD_N; pfam04915 288681015457 DltD central region; Region: DltD_M; pfam04918 288681015458 DltD C-terminal region; Region: DltD_C; pfam04914 288681015459 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 288681015460 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 288681015461 putative active site [active] 288681015462 putative metal binding site [ion binding]; other site 288681015463 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 288681015464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 288681015465 active site 288681015466 phosphorylation site [posttranslational modification] 288681015467 intermolecular recognition site; other site 288681015468 dimerization interface [polypeptide binding]; other site 288681015469 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 288681015470 DNA binding site [nucleotide binding] 288681015471 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 288681015472 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 288681015473 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 288681015474 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 288681015475 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015476 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015477 Probable transposase; Region: OrfB_IS605; pfam01385 288681015478 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015479 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 288681015480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015481 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015482 Probable transposase; Region: OrfB_IS605; pfam01385 288681015483 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015484 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 288681015485 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 288681015486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 288681015487 HTH-like domain; Region: HTH_21; pfam13276 288681015488 Integrase core domain; Region: rve; pfam00665 288681015489 Integrase core domain; Region: rve_2; pfam13333 288681015490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681015491 Helix-turn-helix domain; Region: HTH_28; pfam13518 288681015492 Helix-turn-helix domain; Region: HTH_28; pfam13518 288681015493 N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655 288681015494 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 288681015495 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 288681015496 putative active site [active] 288681015497 putative NTP binding site [chemical binding]; other site 288681015498 putative nucleic acid binding site [nucleotide binding]; other site 288681015499 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 288681015500 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 288681015501 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 288681015502 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 288681015503 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 288681015504 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 288681015505 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 288681015506 Catalytic site [active] 288681015507 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 288681015508 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 288681015509 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 288681015510 DNA binding residues [nucleotide binding] 288681015511 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 288681015512 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015513 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 288681015514 nucleotide binding site [chemical binding]; other site 288681015515 Fibronectin type III protein; Region: DUF3672; pfam12421 288681015516 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 288681015517 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 288681015518 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 288681015519 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 288681015520 Trp repressor protein; Region: Trp_repressor; cl17266 288681015521 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 288681015522 TcpE family; Region: TcpE; pfam12648 288681015523 AAA-like domain; Region: AAA_10; pfam12846 288681015524 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 288681015525 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 288681015526 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 288681015527 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 288681015528 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 288681015529 N-acetyl-D-glucosamine binding site [chemical binding]; other site 288681015530 catalytic residue [active] 288681015531 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 288681015532 NlpC/P60 family; Region: NLPC_P60; pfam00877 288681015533 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 288681015534 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681015535 RNA binding site [nucleotide binding]; other site 288681015536 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 288681015537 RNA binding site [nucleotide binding]; other site 288681015538 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 288681015539 MPN+ (JAMM) motif; other site 288681015540 Zinc-binding site [ion binding]; other site 288681015541 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 288681015542 putative dimer interface [polypeptide binding]; other site 288681015543 catalytic triad [active] 288681015544 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 288681015545 Transposase; Region: DEDD_Tnp_IS110; pfam01548 288681015546 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 288681015547 Helix-turn-helix domain; Region: HTH_17; pfam12728 288681015548 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 288681015549 putative catalytic site [active] 288681015550 putative phosphate binding site [ion binding]; other site 288681015551 putative metal binding site [ion binding]; other site 288681015552 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 288681015553 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_20; cd04679 288681015554 nudix motif; other site 288681015555 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 288681015556 EamA-like transporter family; Region: EamA; pfam00892 288681015557 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 288681015558 dimer interface [polypeptide binding]; other site 288681015559 putative tRNA-binding site [nucleotide binding]; other site 288681015560 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 288681015561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 288681015562 motif II; other site 288681015563 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 288681015564 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 288681015565 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 288681015566 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 288681015567 nonfunctional dihydropyrimidine dehydrogenase (NADPH+) 288681015568 nonfunctional dihydroorotate dehydrogenase 288681015569 Protein of unknown function, DUF606; Region: DUF606; pfam04657 288681015570 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 288681015571 active site 288681015572 NTP binding site [chemical binding]; other site 288681015573 metal binding triad [ion binding]; metal-binding site 288681015574 antibiotic binding site [chemical binding]; other site 288681015575 Protein of unknown function DUF86; Region: DUF86; pfam01934 288681015576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015577 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015578 Probable transposase; Region: OrfB_IS605; pfam01385 288681015579 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015580 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 288681015581 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681015582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 288681015583 Chitin binding domain; Region: Chitin_bind_3; pfam03067 288681015584 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681015585 Interdomain contacts; other site 288681015586 Cytokine receptor motif; other site 288681015587 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 288681015588 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 288681015589 Interdomain contacts; other site 288681015590 Cytokine receptor motif; other site 288681015591 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 288681015592 Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531 288681015593 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 288681015594 catalytic residues [active] 288681015595 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 288681015596 SnoaL-like domain; Region: SnoaL_2; pfam12680 288681015597 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 288681015598 Transposase; Region: HTH_Tnp_1; pfam01527 288681015599 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681015600 putative transposase OrfB; Reviewed; Region: PHA02517 288681015601 HTH-like domain; Region: HTH_21; pfam13276 288681015602 Integrase core domain; Region: rve; pfam00665 288681015603 Integrase core domain; Region: rve_2; pfam13333 288681015604 transposase, C-terminal fragment 288681015605 transposase, N-terminal fragment 288681015606 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681015607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681015608 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288681015609 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 288681015610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015611 putative substrate translocation pore; other site 288681015612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015613 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681015614 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681015615 DNA binding site [nucleotide binding] 288681015616 domain linker motif; other site 288681015617 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681015618 dimerization interface [polypeptide binding]; other site 288681015619 ligand binding site [chemical binding]; other site 288681015620 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681015621 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681015622 DNA binding site [nucleotide binding] 288681015623 domain linker motif; other site 288681015624 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681015625 dimerization interface [polypeptide binding]; other site 288681015626 ligand binding site [chemical binding]; other site 288681015627 polyol permease family; Region: 2A0118; TIGR00897 288681015628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015629 putative substrate translocation pore; other site 288681015630 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 288681015631 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 288681015632 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 288681015633 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681015634 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681015635 substrate binding site [chemical binding]; other site 288681015636 ATP binding site [chemical binding]; other site 288681015637 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 288681015638 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 288681015639 tetrameric interface [polypeptide binding]; other site 288681015640 NAD binding site [chemical binding]; other site 288681015641 catalytic residues [active] 288681015642 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 288681015643 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 288681015644 PYR/PP interface [polypeptide binding]; other site 288681015645 dimer interface [polypeptide binding]; other site 288681015646 TPP binding site [chemical binding]; other site 288681015647 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 288681015648 Ph1570 protein; Region: Ph1570; pfam09638 288681015649 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 288681015650 TPP-binding site; other site 288681015651 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 288681015652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 288681015653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 288681015654 DNA binding site [nucleotide binding] 288681015655 domain linker motif; other site 288681015656 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 288681015657 dimerization interface [polypeptide binding]; other site 288681015658 ligand binding site [chemical binding]; other site 288681015659 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 288681015660 intersubunit interface [polypeptide binding]; other site 288681015661 active site 288681015662 zinc binding site [ion binding]; other site 288681015663 Na+ binding site [ion binding]; other site 288681015664 KduI/IolB family; Region: KduI; pfam04962 288681015665 putative transposase OrfB; Reviewed; Region: PHA02517 288681015666 HTH-like domain; Region: HTH_21; pfam13276 288681015667 Integrase core domain; Region: rve; pfam00665 288681015668 Integrase core domain; Region: rve_2; pfam13333 288681015669 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681015670 Helix-turn-helix domain; Region: HTH_28; pfam13518 288681015671 Helix-turn-helix domain; Region: HTH_28; pfam13518 288681015672 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681015673 Walker A motif; other site 288681015674 ATP binding site [chemical binding]; other site 288681015675 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 288681015676 aminotransferase A; Validated; Region: PRK07683 288681015677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 288681015678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 288681015679 homodimer interface [polypeptide binding]; other site 288681015680 catalytic residue [active] 288681015681 nonfuctional DNA topoisomerase III 288681015682 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 288681015683 metal ion-dependent adhesion site (MIDAS); other site 288681015684 nonfunctional transposase 288681015685 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 288681015686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 288681015687 Walker A motif; other site 288681015688 ATP binding site [chemical binding]; other site 288681015689 Walker B motif; other site 288681015690 arginine finger; other site 288681015691 putative transposase OrfB; Reviewed; Region: PHA02517 288681015692 HTH-like domain; Region: HTH_21; pfam13276 288681015693 Integrase core domain; Region: rve; pfam00665 288681015694 Integrase core domain; Region: rve_2; pfam13333 288681015695 YolD-like protein; Region: YolD; pfam08863 288681015696 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 288681015697 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681015698 DNA binding residues [nucleotide binding] 288681015699 drug binding residues [chemical binding]; other site 288681015700 dimer interface [polypeptide binding]; other site 288681015701 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 288681015702 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 288681015703 active site 288681015704 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 288681015705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015706 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015707 Probable transposase; Region: OrfB_IS605; pfam01385 288681015708 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015709 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681015711 TPR motif; other site 288681015712 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015713 binding surface 288681015714 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681015716 TPR motif; other site 288681015717 binding surface 288681015718 nonfunctional conserved hypothetical protein 288681015719 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 288681015720 Transcriptional regulator [Transcription]; Region: IclR; COG1414 288681015721 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 288681015722 Bacterial transcriptional regulator; Region: IclR; pfam01614 288681015723 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 288681015724 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 288681015725 active site 288681015726 intersubunit interface [polypeptide binding]; other site 288681015727 catalytic residue [active] 288681015728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 288681015729 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 288681015730 substrate binding site [chemical binding]; other site 288681015731 ATP binding site [chemical binding]; other site 288681015732 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 288681015733 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 288681015734 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 288681015735 NADP binding site [chemical binding]; other site 288681015736 homodimer interface [polypeptide binding]; other site 288681015737 active site 288681015738 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 288681015739 active pocket/dimerization site; other site 288681015740 active site 288681015741 phosphorylation site [posttranslational modification] 288681015742 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 288681015743 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 288681015744 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 288681015745 active site 288681015746 phosphorylation site [posttranslational modification] 288681015747 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 288681015748 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 288681015749 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 288681015750 substrate binding site [chemical binding]; other site 288681015751 catalytic residues [active] 288681015752 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 288681015753 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 288681015754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681015755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 288681015756 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 288681015757 active site 288681015758 catalytic residues [active] 288681015759 galactokinase; Provisional; Region: PRK05322 288681015760 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 288681015761 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 288681015762 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 288681015763 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 288681015764 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 288681015765 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 288681015766 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 288681015767 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 288681015768 putative NAD(P) binding site [chemical binding]; other site 288681015769 catalytic Zn binding site [ion binding]; other site 288681015770 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015772 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681015773 MarR family; Region: MarR; pfam01047 288681015774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015775 Major Facilitator Superfamily; Region: MFS_1; pfam07690 288681015776 putative substrate translocation pore; other site 288681015777 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 288681015778 MarR family; Region: MarR; pfam01047 288681015779 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681015780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681015781 Zn binding site [ion binding]; other site 288681015782 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681015783 Zn binding site [ion binding]; other site 288681015784 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 288681015785 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 288681015786 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 288681015787 Zn binding site [ion binding]; other site 288681015788 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 288681015789 Zn binding site [ion binding]; other site 288681015790 Predicted esterase [General function prediction only]; Region: COG0400 288681015791 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 288681015792 glucose-1-dehydrogenase; Provisional; Region: PRK08936 288681015793 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 288681015794 NAD binding site [chemical binding]; other site 288681015795 homodimer interface [polypeptide binding]; other site 288681015796 active site 288681015797 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 288681015798 dimer interface [polypeptide binding]; other site 288681015799 FMN binding site [chemical binding]; other site 288681015800 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 288681015801 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 288681015802 putative active site [active] 288681015803 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681015804 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681015805 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 288681015806 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681015807 active site 288681015808 Zn binding site [ion binding]; other site 288681015809 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 288681015810 PAS domain; Region: PAS_9; pfam13426 288681015811 putative active site [active] 288681015812 heme pocket [chemical binding]; other site 288681015813 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681015814 dimer interface [polypeptide binding]; other site 288681015815 putative CheW interface [polypeptide binding]; other site 288681015816 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 288681015817 Integrase core domain; Region: rve; pfam00665 288681015818 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 288681015819 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 288681015820 dimerization interface [polypeptide binding]; other site 288681015821 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 288681015822 dimer interface [polypeptide binding]; other site 288681015823 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 288681015824 putative CheW interface [polypeptide binding]; other site 288681015825 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 288681015826 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 288681015827 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 288681015828 active site 288681015829 Zn binding site [ion binding]; other site 288681015830 similar to viral enhancin fragment 288681015831 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 288681015832 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 288681015833 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 288681015834 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 288681015835 active site 288681015836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 288681015837 S-adenosylmethionine binding site [chemical binding]; other site 288681015838 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681015839 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 288681015840 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 288681015841 putative active site [active] 288681015842 putative metal binding site [ion binding]; other site 288681015843 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015844 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015845 Probable transposase; Region: OrfB_IS605; pfam01385 288681015846 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015847 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 288681015848 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 288681015849 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 288681015850 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 288681015851 tol-pal system protein YbgF; Provisional; Region: PRK10803 288681015852 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 288681015853 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 288681015854 active site 288681015855 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 288681015856 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015857 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015858 Probable transposase; Region: OrfB_IS605; pfam01385 288681015859 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015860 CHRD domain; Region: CHRD; pfam07452 288681015861 Probable transposase; Region: OrfB_IS605; pfam01385 288681015862 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015863 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 288681015864 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681015865 SpoVA protein; Region: SpoVA; cl04298 288681015866 Predicted membrane protein [Function unknown]; Region: COG2323 288681015867 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 288681015868 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015869 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 288681015870 Int/Topo IB signature motif; other site 288681015871 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 288681015872 putative FMN binding site [chemical binding]; other site 288681015873 NADPH bind site [chemical binding]; other site 288681015874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 288681015875 putative substrate translocation pore; other site 288681015876 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 288681015877 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 288681015878 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 288681015879 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 288681015880 dimer interface [polypeptide binding]; other site 288681015881 active site 288681015882 CoA binding pocket [chemical binding]; other site 288681015883 similar to IS231 transposase 288681015884 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288681015885 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 288681015886 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288681015887 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015888 non-specific DNA binding site [nucleotide binding]; other site 288681015889 salt bridge; other site 288681015890 sequence-specific DNA binding site [nucleotide binding]; other site 288681015891 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015893 non-specific DNA binding site [nucleotide binding]; other site 288681015894 salt bridge; other site 288681015895 sequence-specific DNA binding site [nucleotide binding]; other site 288681015896 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 288681015897 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015898 nonfunctional IS231 transposase 288681015899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015900 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 288681015901 Ligand binding site; other site 288681015902 Putative Catalytic site; other site 288681015903 DXD motif; other site 288681015904 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 288681015905 active site 288681015906 Probable transposase; Region: OrfB_IS605; pfam01385 288681015907 Probable transposase; Region: OrfB_IS605; pfam01385 288681015908 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015909 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 288681015910 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 288681015911 dimerization interface [polypeptide binding]; other site 288681015912 putative DNA binding site [nucleotide binding]; other site 288681015913 putative Zn2+ binding site [ion binding]; other site 288681015914 putative transporter; Provisional; Region: PRK11660 288681015915 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 288681015916 Sulfate transporter family; Region: Sulfate_transp; pfam00916 288681015917 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 288681015918 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 288681015919 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 288681015920 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 288681015921 PhnA protein; Region: PhnA; pfam03831 288681015922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 288681015923 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 288681015924 Probable transposase; Region: OrfB_IS605; pfam01385 288681015925 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 288681015926 Recombination protein U; Region: RecU; cl01314 288681015927 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 288681015928 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015929 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 288681015930 nonfunctional IS231 transposase 288681015931 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 288681015932 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 288681015933 homodimer interface [polypeptide binding]; other site 288681015934 dUTPase; Region: dUTPase_2; pfam08761 288681015935 metal binding site [ion binding]; metal-binding site 288681015936 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 288681015937 YopX protein; Region: YopX; pfam09643 288681015938 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 288681015939 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 288681015940 putative active site [active] 288681015941 putative NTP binding site [chemical binding]; other site 288681015942 putative nucleic acid binding site [nucleotide binding]; other site 288681015943 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 288681015944 active site 288681015945 Protein of unknown function (DUF998); Region: DUF998; pfam06197 288681015946 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 288681015947 Helix-turn-helix domain; Region: HTH_36; pfam13730 288681015948 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681015949 AAA domain; Region: AAA_31; pfam13614 288681015950 P-loop; other site 288681015951 Magnesium ion binding site [ion binding]; other site 288681015952 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 288681015953 Magnesium ion binding site [ion binding]; other site 288681015954 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681015955 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681015956 DNA binding residues [nucleotide binding] 288681015957 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 288681015958 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 288681015959 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015960 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681015961 non-specific DNA binding site [nucleotide binding]; other site 288681015962 salt bridge; other site 288681015963 sequence-specific DNA binding site [nucleotide binding]; other site 288681015964 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681015965 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 288681015966 CAAX protease self-immunity; Region: Abi; cl00558 288681015967 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 288681015968 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681015969 active site 288681015970 DNA binding site [nucleotide binding] 288681015971 Int/Topo IB signature motif; other site 288681015972 SEC-C motif; Region: SEC-C; pfam02810 288681015973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 288681015974 TPR motif; other site 288681015975 binding surface 288681015976 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015977 Tetratricopeptide repeat; Region: TPR_12; pfam13424 288681015978 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 288681015979 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 288681015980 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681015981 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681015982 non-specific DNA binding site [nucleotide binding]; other site 288681015983 salt bridge; other site 288681015984 sequence-specific DNA binding site [nucleotide binding]; other site 288681015985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015986 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 288681015988 Helix-turn-helix domain; Region: HTH_28; pfam13518 288681015989 putative transposase OrfB; Reviewed; Region: PHA02517 288681015990 HTH-like domain; Region: HTH_21; pfam13276 288681015991 Integrase core domain; Region: rve; pfam00665 288681015992 Integrase core domain; Region: rve_2; pfam13333 288681015993 nonfunctional ImpB/MucB/SamB family protein, N-terminal 288681015994 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 288681015995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 288681015996 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 288681015997 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 288681015998 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 288681015999 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 288681016000 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 288681016001 Sodium Bile acid symporter family; Region: SBF; cl17470 288681016002 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 288681016003 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 288681016004 metal binding site [ion binding]; metal-binding site 288681016005 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 288681016006 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 288681016007 ABC-ATPase subunit interface; other site 288681016008 dimer interface [polypeptide binding]; other site 288681016009 putative PBP binding regions; other site 288681016010 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 288681016011 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 288681016012 multiple promoter invertase; Provisional; Region: mpi; PRK13413 288681016013 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681016014 catalytic residues [active] 288681016015 catalytic nucleophile [active] 288681016016 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681016017 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681016018 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681016019 Synaptic Site I dimer interface [polypeptide binding]; other site 288681016020 DNA binding site [nucleotide binding] 288681016021 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 288681016022 DNA-binding interface [nucleotide binding]; DNA binding site 288681016023 nonfunctional transposase 288681016024 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 288681016025 active site 288681016026 catalytic residues [active] 288681016027 DNA binding site [nucleotide binding] 288681016028 Int/Topo IB signature motif; other site 288681016029 Helix-turn-helix domain; Region: HTH_17; pfam12728 288681016030 Helix-turn-helix domain; Region: HTH_17; pfam12728 288681016031 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 288681016032 active site 288681016033 catalytic residues [active] 288681016034 DNA binding site [nucleotide binding] 288681016035 Int/Topo IB signature motif; other site 288681016036 nonfunctional impB/mucB/samB family protein, C-terminal 288681016037 YolD-like protein; Region: YolD; pfam08863 288681016038 Abi-like protein; Region: Abi_2; pfam07751 288681016039 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 288681016040 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 288681016041 catalytic residues [active] 288681016042 catalytic nucleophile [active] 288681016043 Presynaptic Site I dimer interface [polypeptide binding]; other site 288681016044 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 288681016045 Synaptic Flat tetramer interface [polypeptide binding]; other site 288681016046 Synaptic Site I dimer interface [polypeptide binding]; other site 288681016047 DNA binding site [nucleotide binding] 288681016048 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 288681016049 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681016050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681016051 non-specific DNA binding site [nucleotide binding]; other site 288681016052 salt bridge; other site 288681016053 sequence-specific DNA binding site [nucleotide binding]; other site 288681016054 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 288681016055 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 288681016056 MarR family; Region: MarR_2; pfam12802 288681016057 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 288681016058 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 288681016059 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 288681016060 putative active site [active] 288681016061 nucleotide binding site [chemical binding]; other site 288681016062 nudix motif; other site 288681016063 putative metal binding site [ion binding]; other site 288681016064 Haemolysin XhlA; Region: XhlA; pfam10779 288681016065 CAAX protease self-immunity; Region: Abi; pfam02517 288681016066 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 288681016067 MarR family; Region: MarR_2; cl17246 288681016068 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 288681016069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681016070 non-specific DNA binding site [nucleotide binding]; other site 288681016071 salt bridge; other site 288681016072 sequence-specific DNA binding site [nucleotide binding]; other site 288681016073 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 288681016074 non-specific DNA binding site [nucleotide binding]; other site 288681016075 salt bridge; other site 288681016076 sequence-specific DNA binding site [nucleotide binding]; other site 288681016077 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 288681016078 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 288681016079 DNA binding residues [nucleotide binding] 288681016080 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 288681016081 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 288681016082 active site 288681016083 DNA binding site [nucleotide binding] 288681016084 Int/Topo IB signature motif; other site