-- dump date 20140618_214807 -- class Genbank::misc_feature -- table misc_feature_note -- id note 347495000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 347495000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 347495000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495000004 Walker A motif; other site 347495000005 ATP binding site [chemical binding]; other site 347495000006 Walker B motif; other site 347495000007 arginine finger; other site 347495000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 347495000009 DnaA box-binding interface [nucleotide binding]; other site 347495000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 347495000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 347495000012 putative DNA binding surface [nucleotide binding]; other site 347495000013 dimer interface [polypeptide binding]; other site 347495000014 beta-clamp/clamp loader binding surface; other site 347495000015 beta-clamp/translesion DNA polymerase binding surface; other site 347495000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 347495000017 recombination protein F; Reviewed; Region: recF; PRK00064 347495000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 347495000019 Walker A/P-loop; other site 347495000020 ATP binding site [chemical binding]; other site 347495000021 Q-loop/lid; other site 347495000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495000023 ABC transporter signature motif; other site 347495000024 Walker B; other site 347495000025 D-loop; other site 347495000026 H-loop/switch region; other site 347495000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 347495000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495000029 Mg2+ binding site [ion binding]; other site 347495000030 G-X-G motif; other site 347495000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 347495000032 anchoring element; other site 347495000033 dimer interface [polypeptide binding]; other site 347495000034 ATP binding site [chemical binding]; other site 347495000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 347495000036 active site 347495000037 putative metal-binding site [ion binding]; other site 347495000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 347495000039 DNA gyrase subunit A; Validated; Region: PRK05560 347495000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 347495000041 CAP-like domain; other site 347495000042 active site 347495000043 primary dimer interface [polypeptide binding]; other site 347495000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495000050 YaaC-like Protein; Region: YaaC; pfam14175 347495000051 potential frameshift: common BLAST hit: gi|227812686|ref|YP_002812695.1| inosine 5'-monophosphate dehydrogenase 347495000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 347495000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 347495000054 FOG: CBS domain [General function prediction only]; Region: COG0517 347495000055 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 347495000056 phosphate binding site [ion binding]; other site 347495000057 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 347495000058 phosphate binding site [ion binding]; other site 347495000059 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 347495000060 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495000061 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 347495000062 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 347495000063 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 347495000064 active site 347495000065 multimer interface [polypeptide binding]; other site 347495000066 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 347495000067 predicted active site [active] 347495000068 catalytic triad [active] 347495000069 seryl-tRNA synthetase; Provisional; Region: PRK05431 347495000070 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 347495000071 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 347495000072 dimer interface [polypeptide binding]; other site 347495000073 active site 347495000074 motif 1; other site 347495000075 motif 2; other site 347495000076 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 347495000077 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 347495000078 DNA binding residues [nucleotide binding] 347495000079 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 347495000080 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 347495000081 Substrate-binding site [chemical binding]; other site 347495000082 Substrate specificity [chemical binding]; other site 347495000083 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 347495000084 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 347495000085 Substrate-binding site [chemical binding]; other site 347495000086 Substrate specificity [chemical binding]; other site 347495000087 Isochorismatase family; Region: Isochorismatase; pfam00857 347495000088 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 347495000089 catalytic triad [active] 347495000090 conserved cis-peptide bond; other site 347495000091 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 347495000092 nucleoside/Zn binding site; other site 347495000093 dimer interface [polypeptide binding]; other site 347495000094 catalytic motif [active] 347495000095 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 347495000096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495000097 Walker A motif; other site 347495000098 ATP binding site [chemical binding]; other site 347495000099 Walker B motif; other site 347495000100 arginine finger; other site 347495000101 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 347495000102 hypothetical protein; Validated; Region: PRK00153 347495000103 recombination protein RecR; Reviewed; Region: recR; PRK00076 347495000104 RecR protein; Region: RecR; pfam02132 347495000105 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 347495000106 putative active site [active] 347495000107 putative metal-binding site [ion binding]; other site 347495000108 tetramer interface [polypeptide binding]; other site 347495000109 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 347495000110 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 347495000111 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 347495000112 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 347495000113 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 347495000114 homodimer interface [polypeptide binding]; other site 347495000115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495000116 catalytic residue [active] 347495000117 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 347495000118 thymidylate kinase; Validated; Region: tmk; PRK00698 347495000119 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 347495000120 TMP-binding site; other site 347495000121 ATP-binding site [chemical binding]; other site 347495000122 DNA polymerase III subunit delta'; Validated; Region: PRK08058 347495000123 DNA polymerase III subunit delta'; Validated; Region: PRK08485 347495000124 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 347495000125 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 347495000126 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 347495000127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495000128 S-adenosylmethionine binding site [chemical binding]; other site 347495000129 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 347495000130 catalytic site [active] 347495000131 metal binding site [ion binding]; metal-binding site 347495000132 Predicted methyltransferases [General function prediction only]; Region: COG0313 347495000133 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 347495000134 putative SAM binding site [chemical binding]; other site 347495000135 putative homodimer interface [polypeptide binding]; other site 347495000136 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 347495000137 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 347495000138 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 347495000139 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 347495000140 active site 347495000141 HIGH motif; other site 347495000142 KMSKS motif; other site 347495000143 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 347495000144 tRNA binding surface [nucleotide binding]; other site 347495000145 anticodon binding site; other site 347495000146 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 347495000147 dimer interface [polypeptide binding]; other site 347495000148 putative tRNA-binding site [nucleotide binding]; other site 347495000149 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 347495000150 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 347495000151 active site 347495000152 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 347495000153 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 347495000154 putative active site [active] 347495000155 putative metal binding site [ion binding]; other site 347495000156 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 347495000157 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 347495000158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495000159 S-adenosylmethionine binding site [chemical binding]; other site 347495000160 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 347495000161 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 347495000162 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495000163 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 347495000164 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 347495000165 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 347495000166 pur operon repressor; Provisional; Region: PRK09213 347495000167 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 347495000168 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495000169 active site 347495000170 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 347495000171 homotrimer interaction site [polypeptide binding]; other site 347495000172 putative active site [active] 347495000173 regulatory protein SpoVG; Reviewed; Region: PRK13259 347495000174 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 347495000175 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 347495000176 Substrate binding site; other site 347495000177 Mg++ binding site; other site 347495000178 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 347495000179 active site 347495000180 substrate binding site [chemical binding]; other site 347495000181 CoA binding site [chemical binding]; other site 347495000182 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 347495000183 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 347495000184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495000185 active site 347495000186 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 347495000187 putative active site [active] 347495000188 catalytic residue [active] 347495000189 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 347495000190 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 347495000191 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 347495000192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495000193 ATP binding site [chemical binding]; other site 347495000194 putative Mg++ binding site [ion binding]; other site 347495000195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495000196 nucleotide binding region [chemical binding]; other site 347495000197 ATP-binding site [chemical binding]; other site 347495000198 TRCF domain; Region: TRCF; pfam03461 347495000199 stage V sporulation protein T; Region: spore_V_T; TIGR02851 347495000200 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 347495000201 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 347495000202 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 347495000203 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 347495000204 putative SAM binding site [chemical binding]; other site 347495000205 putative homodimer interface [polypeptide binding]; other site 347495000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 347495000207 homodimer interface [polypeptide binding]; other site 347495000208 metal binding site [ion binding]; metal-binding site 347495000209 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 347495000210 homodimer interface [polypeptide binding]; other site 347495000211 active site 347495000212 putative chemical substrate binding site [chemical binding]; other site 347495000213 metal binding site [ion binding]; metal-binding site 347495000214 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495000215 RNA binding surface [nucleotide binding]; other site 347495000216 sporulation protein YabP; Region: spore_yabP; TIGR02892 347495000217 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 347495000218 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 347495000219 Septum formation initiator; Region: DivIC; pfam04977 347495000220 hypothetical protein; Provisional; Region: PRK08582 347495000221 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 347495000222 RNA binding site [nucleotide binding]; other site 347495000223 stage II sporulation protein E; Region: spore_II_E; TIGR02865 347495000224 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 347495000225 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 347495000226 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 347495000227 Ligand Binding Site [chemical binding]; other site 347495000228 TilS substrate binding domain; Region: TilS; pfam09179 347495000229 TilS substrate C-terminal domain; Region: TilS_C; smart00977 347495000230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495000231 active site 347495000232 FtsH Extracellular; Region: FtsH_ext; pfam06480 347495000233 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 347495000234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495000235 Walker A motif; other site 347495000236 ATP binding site [chemical binding]; other site 347495000237 Walker B motif; other site 347495000238 arginine finger; other site 347495000239 Peptidase family M41; Region: Peptidase_M41; pfam01434 347495000240 pantothenate kinase; Reviewed; Region: PRK13318 347495000241 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 347495000242 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 347495000243 dimerization interface [polypeptide binding]; other site 347495000244 domain crossover interface; other site 347495000245 redox-dependent activation switch; other site 347495000246 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 347495000247 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 347495000248 dimer interface [polypeptide binding]; other site 347495000249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495000250 catalytic residue [active] 347495000251 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 347495000252 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 347495000253 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 347495000254 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 347495000255 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 347495000256 glutamine binding [chemical binding]; other site 347495000257 catalytic triad [active] 347495000258 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 347495000259 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 347495000260 homodimer interface [polypeptide binding]; other site 347495000261 substrate-cofactor binding pocket; other site 347495000262 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495000263 catalytic residue [active] 347495000264 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 347495000265 dihydropteroate synthase; Region: DHPS; TIGR01496 347495000266 substrate binding pocket [chemical binding]; other site 347495000267 dimer interface [polypeptide binding]; other site 347495000268 inhibitor binding site; inhibition site 347495000269 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 347495000270 homooctamer interface [polypeptide binding]; other site 347495000271 active site 347495000272 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 347495000273 catalytic center binding site [active] 347495000274 ATP binding site [chemical binding]; other site 347495000275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495000276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495000277 non-specific DNA binding site [nucleotide binding]; other site 347495000278 salt bridge; other site 347495000279 sequence-specific DNA binding site [nucleotide binding]; other site 347495000280 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 347495000281 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 347495000282 FMN binding site [chemical binding]; other site 347495000283 active site 347495000284 catalytic residues [active] 347495000285 substrate binding site [chemical binding]; other site 347495000286 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 347495000287 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 347495000288 dimer interface [polypeptide binding]; other site 347495000289 putative anticodon binding site; other site 347495000290 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 347495000291 motif 1; other site 347495000292 active site 347495000293 motif 2; other site 347495000294 motif 3; other site 347495000295 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 347495000296 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 347495000297 UvrB/uvrC motif; Region: UVR; pfam02151 347495000298 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 347495000299 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 347495000300 ADP binding site [chemical binding]; other site 347495000301 phosphagen binding site; other site 347495000302 substrate specificity loop; other site 347495000303 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 347495000304 Clp amino terminal domain; Region: Clp_N; pfam02861 347495000305 Clp amino terminal domain; Region: Clp_N; pfam02861 347495000306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495000307 Walker A motif; other site 347495000308 ATP binding site [chemical binding]; other site 347495000309 Walker B motif; other site 347495000310 arginine finger; other site 347495000311 UvrB/uvrC motif; Region: UVR; pfam02151 347495000312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495000313 Walker A motif; other site 347495000314 ATP binding site [chemical binding]; other site 347495000315 Walker B motif; other site 347495000316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 347495000317 DNA repair protein RadA; Provisional; Region: PRK11823 347495000318 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 347495000319 Walker A motif/ATP binding site; other site 347495000320 ATP binding site [chemical binding]; other site 347495000321 Walker B motif; other site 347495000322 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 347495000323 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 347495000324 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 347495000325 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 347495000326 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 347495000327 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 347495000328 putative active site [active] 347495000329 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 347495000330 substrate binding site; other site 347495000331 dimer interface; other site 347495000332 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 347495000333 homotrimer interaction site [polypeptide binding]; other site 347495000334 zinc binding site [ion binding]; other site 347495000335 CDP-binding sites; other site 347495000336 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 347495000337 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 347495000338 active site 347495000339 HIGH motif; other site 347495000340 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 347495000341 active site 347495000342 KMSKS motif; other site 347495000343 serine O-acetyltransferase; Region: cysE; TIGR01172 347495000344 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 347495000345 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 347495000346 trimer interface [polypeptide binding]; other site 347495000347 active site 347495000348 substrate binding site [chemical binding]; other site 347495000349 CoA binding site [chemical binding]; other site 347495000350 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 347495000351 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 347495000352 active site 347495000353 HIGH motif; other site 347495000354 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 347495000355 KMSKS motif; other site 347495000356 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 347495000357 tRNA binding surface [nucleotide binding]; other site 347495000358 anticodon binding site; other site 347495000359 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 347495000360 active site 347495000361 metal binding site [ion binding]; metal-binding site 347495000362 dimerization interface [polypeptide binding]; other site 347495000363 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 347495000364 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 347495000365 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 347495000366 YacP-like NYN domain; Region: NYN_YacP; pfam05991 347495000367 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 347495000368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495000369 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 347495000370 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 347495000371 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 347495000372 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 347495000373 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 347495000374 putative homodimer interface [polypeptide binding]; other site 347495000375 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 347495000376 heterodimer interface [polypeptide binding]; other site 347495000377 homodimer interface [polypeptide binding]; other site 347495000378 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 347495000379 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 347495000380 23S rRNA interface [nucleotide binding]; other site 347495000381 L7/L12 interface [polypeptide binding]; other site 347495000382 putative thiostrepton binding site; other site 347495000383 L25 interface [polypeptide binding]; other site 347495000384 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 347495000385 mRNA/rRNA interface [nucleotide binding]; other site 347495000386 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 347495000387 23S rRNA interface [nucleotide binding]; other site 347495000388 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 347495000389 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 347495000390 core dimer interface [polypeptide binding]; other site 347495000391 peripheral dimer interface [polypeptide binding]; other site 347495000392 L10 interface [polypeptide binding]; other site 347495000393 L11 interface [polypeptide binding]; other site 347495000394 putative EF-Tu interaction site [polypeptide binding]; other site 347495000395 putative EF-G interaction site [polypeptide binding]; other site 347495000396 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 347495000397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495000398 S-adenosylmethionine binding site [chemical binding]; other site 347495000399 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 347495000400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 347495000401 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 347495000402 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 347495000403 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 347495000404 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 347495000405 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 347495000406 RPB10 interaction site [polypeptide binding]; other site 347495000407 RPB1 interaction site [polypeptide binding]; other site 347495000408 RPB11 interaction site [polypeptide binding]; other site 347495000409 RPB3 interaction site [polypeptide binding]; other site 347495000410 RPB12 interaction site [polypeptide binding]; other site 347495000411 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 347495000412 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 347495000413 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 347495000414 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 347495000415 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 347495000416 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 347495000417 G-loop; other site 347495000418 DNA binding site [nucleotide binding] 347495000419 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 347495000420 hypothetical protein; Provisional; Region: PRK06683 347495000421 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 347495000422 S17 interaction site [polypeptide binding]; other site 347495000423 S8 interaction site; other site 347495000424 16S rRNA interaction site [nucleotide binding]; other site 347495000425 streptomycin interaction site [chemical binding]; other site 347495000426 23S rRNA interaction site [nucleotide binding]; other site 347495000427 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 347495000428 30S ribosomal protein S7; Validated; Region: PRK05302 347495000429 elongation factor G; Reviewed; Region: PRK00007 347495000430 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 347495000431 G1 box; other site 347495000432 putative GEF interaction site [polypeptide binding]; other site 347495000433 GTP/Mg2+ binding site [chemical binding]; other site 347495000434 Switch I region; other site 347495000435 G2 box; other site 347495000436 G3 box; other site 347495000437 Switch II region; other site 347495000438 G4 box; other site 347495000439 G5 box; other site 347495000440 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 347495000441 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 347495000442 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 347495000443 elongation factor Tu; Reviewed; Region: PRK00049 347495000444 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 347495000445 G1 box; other site 347495000446 GEF interaction site [polypeptide binding]; other site 347495000447 GTP/Mg2+ binding site [chemical binding]; other site 347495000448 Switch I region; other site 347495000449 G2 box; other site 347495000450 G3 box; other site 347495000451 Switch II region; other site 347495000452 G4 box; other site 347495000453 G5 box; other site 347495000454 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 347495000455 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 347495000456 Antibiotic Binding Site [chemical binding]; other site 347495000457 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 347495000458 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 347495000459 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 347495000460 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 347495000461 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 347495000462 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 347495000463 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 347495000464 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 347495000465 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 347495000466 putative translocon binding site; other site 347495000467 protein-rRNA interface [nucleotide binding]; other site 347495000468 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 347495000469 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 347495000470 G-X-X-G motif; other site 347495000471 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 347495000472 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 347495000473 23S rRNA interface [nucleotide binding]; other site 347495000474 5S rRNA interface [nucleotide binding]; other site 347495000475 putative antibiotic binding site [chemical binding]; other site 347495000476 L25 interface [polypeptide binding]; other site 347495000477 L27 interface [polypeptide binding]; other site 347495000478 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 347495000479 23S rRNA interface [nucleotide binding]; other site 347495000480 putative translocon interaction site; other site 347495000481 signal recognition particle (SRP54) interaction site; other site 347495000482 L23 interface [polypeptide binding]; other site 347495000483 trigger factor interaction site; other site 347495000484 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 347495000485 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 347495000486 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 347495000487 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 347495000488 RNA binding site [nucleotide binding]; other site 347495000489 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 347495000490 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 347495000491 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 347495000492 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 347495000493 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 347495000494 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 347495000495 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 347495000496 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 347495000497 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 347495000498 5S rRNA interface [nucleotide binding]; other site 347495000499 L27 interface [polypeptide binding]; other site 347495000500 23S rRNA interface [nucleotide binding]; other site 347495000501 L5 interface [polypeptide binding]; other site 347495000502 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 347495000503 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 347495000504 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 347495000505 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 347495000506 23S rRNA binding site [nucleotide binding]; other site 347495000507 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 347495000508 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 347495000509 SecY translocase; Region: SecY; pfam00344 347495000510 adenylate kinase; Reviewed; Region: adk; PRK00279 347495000511 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 347495000512 AMP-binding site [chemical binding]; other site 347495000513 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 347495000514 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 347495000515 active site 347495000516 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 347495000517 rRNA binding site [nucleotide binding]; other site 347495000518 predicted 30S ribosome binding site; other site 347495000519 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 347495000520 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 347495000521 30S ribosomal protein S13; Region: bact_S13; TIGR03631 347495000522 30S ribosomal protein S11; Validated; Region: PRK05309 347495000523 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 347495000524 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 347495000525 alphaNTD - beta interaction site [polypeptide binding]; other site 347495000526 alphaNTD homodimer interface [polypeptide binding]; other site 347495000527 alphaNTD - beta' interaction site [polypeptide binding]; other site 347495000528 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 347495000529 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 347495000530 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 347495000531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 347495000532 Walker A/P-loop; other site 347495000533 ATP binding site [chemical binding]; other site 347495000534 Q-loop/lid; other site 347495000535 ABC transporter signature motif; other site 347495000536 Walker B; other site 347495000537 D-loop; other site 347495000538 H-loop/switch region; other site 347495000539 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 347495000540 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 347495000541 Walker A/P-loop; other site 347495000542 ATP binding site [chemical binding]; other site 347495000543 Q-loop/lid; other site 347495000544 ABC transporter signature motif; other site 347495000545 Walker B; other site 347495000546 D-loop; other site 347495000547 H-loop/switch region; other site 347495000548 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 347495000549 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 347495000550 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 347495000551 dimerization interface 3.5A [polypeptide binding]; other site 347495000552 active site 347495000553 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 347495000554 23S rRNA interface [nucleotide binding]; other site 347495000555 L3 interface [polypeptide binding]; other site 347495000556 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 347495000557 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 347495000558 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 347495000559 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 347495000560 active site 347495000561 metal binding site [ion binding]; metal-binding site 347495000562 Domain of unknown function DUF59; Region: DUF59; pfam01883 347495000563 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 347495000564 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 347495000565 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 347495000566 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495000567 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 347495000568 NodB motif; other site 347495000569 putative active site [active] 347495000570 putative catalytic site [active] 347495000571 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 347495000572 Arginase family; Region: Arginase; cd09989 347495000573 agmatinase; Region: agmatinase; TIGR01230 347495000574 active site 347495000575 Mn binding site [ion binding]; other site 347495000576 oligomer interface [polypeptide binding]; other site 347495000577 Uncharacterized conserved protein [Function unknown]; Region: COG1624 347495000578 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 347495000579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 347495000580 YbbR-like protein; Region: YbbR; pfam07949 347495000581 YbbR-like protein; Region: YbbR; pfam07949 347495000582 YbbR-like protein; Region: YbbR; pfam07949 347495000583 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 347495000584 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 347495000585 active site 347495000586 substrate binding site [chemical binding]; other site 347495000587 metal binding site [ion binding]; metal-binding site 347495000588 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 347495000589 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 347495000590 glutaminase active site [active] 347495000591 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 347495000592 dimer interface [polypeptide binding]; other site 347495000593 active site 347495000594 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 347495000595 dimer interface [polypeptide binding]; other site 347495000596 active site 347495000597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 347495000598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495000599 DNA-binding site [nucleotide binding]; DNA binding site 347495000600 FCD domain; Region: FCD; pfam07729 347495000601 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 347495000602 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 347495000603 N- and C-terminal domain interface [polypeptide binding]; other site 347495000604 active site 347495000605 catalytic site [active] 347495000606 metal binding site [ion binding]; metal-binding site 347495000607 carbohydrate binding site [chemical binding]; other site 347495000608 ATP binding site [chemical binding]; other site 347495000609 fructuronate transporter; Provisional; Region: PRK10034; cl15264 347495000610 gluconate transporter; Region: gntP; TIGR00791 347495000611 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 347495000612 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 347495000613 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 347495000614 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 347495000615 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 347495000616 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 347495000617 DoxX; Region: DoxX; cl17842 347495000618 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 347495000619 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 347495000620 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 347495000621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495000622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495000623 DNA binding residues [nucleotide binding] 347495000624 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 347495000625 classical (c) SDRs; Region: SDR_c; cd05233 347495000626 NAD(P) binding site [chemical binding]; other site 347495000627 active site 347495000628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495000629 ABC-ATPase subunit interface; other site 347495000630 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 347495000631 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 347495000632 Walker A/P-loop; other site 347495000633 ATP binding site [chemical binding]; other site 347495000634 Q-loop/lid; other site 347495000635 ABC transporter signature motif; other site 347495000636 Walker B; other site 347495000637 D-loop; other site 347495000638 H-loop/switch region; other site 347495000639 NIL domain; Region: NIL; pfam09383 347495000640 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 347495000641 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 347495000642 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495000643 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 347495000644 putative NAD(P) binding site [chemical binding]; other site 347495000645 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 347495000646 FAD binding domain; Region: FAD_binding_4; pfam01565 347495000647 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495000649 putative substrate translocation pore; other site 347495000650 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 347495000651 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 347495000652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495000653 putative substrate translocation pore; other site 347495000654 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 347495000655 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 347495000656 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495000657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495000658 dimer interface [polypeptide binding]; other site 347495000659 conserved gate region; other site 347495000660 putative PBP binding loops; other site 347495000661 ABC-ATPase subunit interface; other site 347495000662 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 347495000663 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 347495000664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495000665 dimer interface [polypeptide binding]; other site 347495000666 conserved gate region; other site 347495000667 putative PBP binding loops; other site 347495000668 ABC-ATPase subunit interface; other site 347495000669 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 347495000670 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495000671 Walker A/P-loop; other site 347495000672 ATP binding site [chemical binding]; other site 347495000673 Q-loop/lid; other site 347495000674 ABC transporter signature motif; other site 347495000675 Walker B; other site 347495000676 D-loop; other site 347495000677 H-loop/switch region; other site 347495000678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 347495000679 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 347495000680 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495000681 Walker A/P-loop; other site 347495000682 ATP binding site [chemical binding]; other site 347495000683 Q-loop/lid; other site 347495000684 ABC transporter signature motif; other site 347495000685 Walker B; other site 347495000686 D-loop; other site 347495000687 H-loop/switch region; other site 347495000688 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 347495000689 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495000690 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495000691 peptide binding site [polypeptide binding]; other site 347495000692 YusW-like protein; Region: YusW; pfam14039 347495000693 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495000694 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 347495000695 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495000696 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495000697 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495000698 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 347495000699 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 347495000700 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495000701 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495000702 peptide binding site [polypeptide binding]; other site 347495000703 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495000704 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495000705 peptide binding site [polypeptide binding]; other site 347495000706 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 347495000707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 347495000708 active site 347495000709 catalytic tetrad [active] 347495000710 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 347495000711 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 347495000712 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 347495000713 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 347495000714 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 347495000715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495000716 dimer interface [polypeptide binding]; other site 347495000717 conserved gate region; other site 347495000718 putative PBP binding loops; other site 347495000719 ABC-ATPase subunit interface; other site 347495000720 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 347495000721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 347495000722 dimerization interface [polypeptide binding]; other site 347495000723 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495000724 membrane-bound complex binding site; other site 347495000725 hinge residues; other site 347495000726 DNA binding domain, excisionase family; Region: excise; TIGR01764 347495000727 PBP superfamily domain; Region: PBP_like; pfam12727 347495000728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495000729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495000730 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 347495000731 putative dimerization interface [polypeptide binding]; other site 347495000732 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495000733 EamA-like transporter family; Region: EamA; pfam00892 347495000734 YrzO-like protein; Region: YrzO; pfam14142 347495000735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 347495000736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 347495000737 putative acyl-acceptor binding pocket; other site 347495000738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495000739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495000740 DNA binding site [nucleotide binding] 347495000741 domain linker motif; other site 347495000742 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 347495000743 putative ligand binding site [chemical binding]; other site 347495000744 putative dimerization interface [polypeptide binding]; other site 347495000745 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495000746 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495000747 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495000748 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495000749 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 347495000750 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 347495000751 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 347495000752 active site 347495000753 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 347495000754 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 347495000755 C-type lysozyme (1, 4-beta-N-acetylmuramidase, LYZ) and alpha-lactalbumin (lactose synthase B protein, LA). They have a close evolutionary relationship and similar tertiary structure, however, functionally they are quite different. Lysozymes have...; Region: LYZ1; cl17441 347495000756 lysozyme catalytic site [active] 347495000757 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 347495000758 nucleotide binding site/active site [active] 347495000759 HIT family signature motif; other site 347495000760 catalytic residue [active] 347495000761 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495000762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495000763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495000764 ABC transporter; Region: ABC_tran_2; pfam12848 347495000765 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495000766 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 347495000767 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 347495000768 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495000769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495000770 dimer interface [polypeptide binding]; other site 347495000771 conserved gate region; other site 347495000772 putative PBP binding loops; other site 347495000773 ABC-ATPase subunit interface; other site 347495000774 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 347495000775 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 347495000776 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495000777 dimer interface [polypeptide binding]; other site 347495000778 conserved gate region; other site 347495000779 putative PBP binding loops; other site 347495000780 ABC-ATPase subunit interface; other site 347495000781 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 347495000782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495000783 Walker A/P-loop; other site 347495000784 ATP binding site [chemical binding]; other site 347495000785 Q-loop/lid; other site 347495000786 ABC transporter signature motif; other site 347495000787 Walker B; other site 347495000788 D-loop; other site 347495000789 H-loop/switch region; other site 347495000790 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 347495000791 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 347495000792 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495000793 Walker A/P-loop; other site 347495000794 ATP binding site [chemical binding]; other site 347495000795 Q-loop/lid; other site 347495000796 ABC transporter signature motif; other site 347495000797 Walker B; other site 347495000798 D-loop; other site 347495000799 H-loop/switch region; other site 347495000800 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 347495000801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495000802 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495000803 active site 347495000804 motif I; other site 347495000805 motif II; other site 347495000806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495000807 motif II; other site 347495000808 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 347495000809 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 347495000810 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 347495000811 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 347495000812 dimer interface [polypeptide binding]; other site 347495000813 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 347495000814 active site 347495000815 Fe binding site [ion binding]; other site 347495000816 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 347495000817 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 347495000818 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 347495000819 amino acid transporter; Region: 2A0306; TIGR00909 347495000820 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 347495000821 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495000822 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495000823 putative substrate translocation pore; other site 347495000824 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 347495000825 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 347495000826 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 347495000827 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 347495000828 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 347495000829 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 347495000830 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 347495000831 helicase 45; Provisional; Region: PTZ00424 347495000832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 347495000833 ATP binding site [chemical binding]; other site 347495000834 Mg++ binding site [ion binding]; other site 347495000835 motif III; other site 347495000836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495000837 nucleotide binding region [chemical binding]; other site 347495000838 ATP-binding site [chemical binding]; other site 347495000839 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 347495000840 Rhomboid family; Region: Rhomboid; pfam01694 347495000841 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 347495000842 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 347495000843 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 347495000844 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 347495000845 alanine racemase; Reviewed; Region: alr; PRK00053 347495000846 active site 347495000847 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 347495000848 dimer interface [polypeptide binding]; other site 347495000849 substrate binding site [chemical binding]; other site 347495000850 catalytic residues [active] 347495000851 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 347495000852 PemK-like protein; Region: PemK; pfam02452 347495000853 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 347495000854 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 347495000855 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 347495000856 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 347495000857 RNA binding site [nucleotide binding]; other site 347495000858 hypothetical protein; Provisional; Region: PRK04351 347495000859 SprT homologues; Region: SprT; cl01182 347495000860 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 347495000861 Glycoprotease family; Region: Peptidase_M22; pfam00814 347495000862 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 347495000863 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 347495000864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495000865 Coenzyme A binding pocket [chemical binding]; other site 347495000866 UGMP family protein; Validated; Region: PRK09604 347495000867 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 347495000868 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 347495000869 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495000870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495000871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495000872 ABC transporter; Region: ABC_tran_2; pfam12848 347495000873 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495000874 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 347495000875 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 347495000876 CoA binding domain; Region: CoA_binding; pfam02629 347495000877 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 347495000878 CAAX protease self-immunity; Region: Abi; pfam02517 347495000879 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 347495000880 oligomerisation interface [polypeptide binding]; other site 347495000881 mobile loop; other site 347495000882 roof hairpin; other site 347495000883 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 347495000884 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 347495000885 hinge regions; other site 347495000886 stacking interactions; other site 347495000887 Uncharacterized conserved protein [Function unknown]; Region: COG5444 347495000888 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495000889 GMP synthase; Reviewed; Region: guaA; PRK00074 347495000890 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 347495000891 AMP/PPi binding site [chemical binding]; other site 347495000892 candidate oxyanion hole; other site 347495000893 catalytic triad [active] 347495000894 potential glutamine specificity residues [chemical binding]; other site 347495000895 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 347495000896 ATP Binding subdomain [chemical binding]; other site 347495000897 Ligand Binding sites [chemical binding]; other site 347495000898 Dimerization subdomain; other site 347495000899 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 347495000900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495000901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495000902 active site 347495000903 phosphorylation site [posttranslational modification] 347495000904 intermolecular recognition site; other site 347495000905 dimerization interface [polypeptide binding]; other site 347495000906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495000907 DNA binding site [nucleotide binding] 347495000908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495000909 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495000910 dimerization interface [polypeptide binding]; other site 347495000911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495000912 dimer interface [polypeptide binding]; other site 347495000913 phosphorylation site [posttranslational modification] 347495000914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495000915 ATP binding site [chemical binding]; other site 347495000916 Mg2+ binding site [ion binding]; other site 347495000917 G-X-G motif; other site 347495000918 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495000919 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 347495000920 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 347495000921 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 347495000922 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 347495000923 catalytic residues [active] 347495000924 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495000925 EamA-like transporter family; Region: EamA; pfam00892 347495000926 EamA-like transporter family; Region: EamA; pfam00892 347495000927 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 347495000928 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 347495000929 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 347495000930 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 347495000931 NAD binding site [chemical binding]; other site 347495000932 ATP-grasp domain; Region: ATP-grasp; pfam02222 347495000933 adenylosuccinate lyase; Provisional; Region: PRK07492 347495000934 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 347495000935 tetramer interface [polypeptide binding]; other site 347495000936 active site 347495000937 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 347495000938 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 347495000939 ATP binding site [chemical binding]; other site 347495000940 active site 347495000941 substrate binding site [chemical binding]; other site 347495000942 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 347495000943 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 347495000944 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 347495000945 putative active site [active] 347495000946 catalytic triad [active] 347495000947 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 347495000948 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 347495000949 dimerization interface [polypeptide binding]; other site 347495000950 ATP binding site [chemical binding]; other site 347495000951 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 347495000952 dimerization interface [polypeptide binding]; other site 347495000953 ATP binding site [chemical binding]; other site 347495000954 amidophosphoribosyltransferase; Provisional; Region: PRK06781 347495000955 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 347495000956 active site 347495000957 tetramer interface [polypeptide binding]; other site 347495000958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495000959 active site 347495000960 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 347495000961 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 347495000962 dimerization interface [polypeptide binding]; other site 347495000963 putative ATP binding site [chemical binding]; other site 347495000964 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 347495000965 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 347495000966 active site 347495000967 substrate binding site [chemical binding]; other site 347495000968 cosubstrate binding site; other site 347495000969 catalytic site [active] 347495000970 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 347495000971 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 347495000972 purine monophosphate binding site [chemical binding]; other site 347495000973 dimer interface [polypeptide binding]; other site 347495000974 putative catalytic residues [active] 347495000975 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 347495000976 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 347495000977 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 347495000978 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 347495000979 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 347495000980 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 347495000981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 347495000982 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 347495000983 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 347495000984 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 347495000985 PcrB family; Region: PcrB; pfam01884 347495000986 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 347495000987 substrate binding site [chemical binding]; other site 347495000988 putative active site [active] 347495000989 dimer interface [polypeptide binding]; other site 347495000990 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 347495000991 Part of AAA domain; Region: AAA_19; pfam13245 347495000992 Family description; Region: UvrD_C_2; pfam13538 347495000993 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 347495000994 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 347495000995 nucleotide binding pocket [chemical binding]; other site 347495000996 K-X-D-G motif; other site 347495000997 catalytic site [active] 347495000998 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 347495000999 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 347495001000 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 347495001001 Dimer interface [polypeptide binding]; other site 347495001002 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 347495001003 putative dimer interface [polypeptide binding]; other site 347495001004 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 347495001005 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 347495001006 putative dimer interface [polypeptide binding]; other site 347495001007 hypothetical protein; Provisional; Region: PRK10621 347495001008 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495001009 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 347495001010 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 347495001011 Glutamate binding site [chemical binding]; other site 347495001012 homodimer interface [polypeptide binding]; other site 347495001013 NAD binding site [chemical binding]; other site 347495001014 catalytic residues [active] 347495001015 Isochorismatase family; Region: Isochorismatase; pfam00857 347495001016 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 347495001017 catalytic triad [active] 347495001018 conserved cis-peptide bond; other site 347495001019 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 347495001020 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 347495001021 Walker A/P-loop; other site 347495001022 ATP binding site [chemical binding]; other site 347495001023 Q-loop/lid; other site 347495001024 ABC transporter signature motif; other site 347495001025 Walker B; other site 347495001026 D-loop; other site 347495001027 H-loop/switch region; other site 347495001028 NIL domain; Region: NIL; pfam09383 347495001029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495001030 dimer interface [polypeptide binding]; other site 347495001031 conserved gate region; other site 347495001032 ABC-ATPase subunit interface; other site 347495001033 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 347495001034 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 347495001035 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 347495001036 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 347495001037 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 347495001038 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 347495001039 P loop; other site 347495001040 Nucleotide binding site [chemical binding]; other site 347495001041 DTAP/Switch II; other site 347495001042 Switch I; other site 347495001043 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 347495001044 putative dimer interface [polypeptide binding]; other site 347495001045 MarR family; Region: MarR; pfam01047 347495001046 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495001047 MarR family; Region: MarR_2; cl17246 347495001048 yiaA/B two helix domain; Region: YiaAB; pfam05360 347495001049 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 347495001050 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 347495001051 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 347495001052 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 347495001053 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 347495001054 GatB domain; Region: GatB_Yqey; pfam02637 347495001055 putative lipid kinase; Reviewed; Region: PRK13337 347495001056 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 347495001057 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 347495001058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495001059 motif II; other site 347495001060 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 347495001061 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495001062 inhibitor-cofactor binding pocket; inhibition site 347495001063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495001064 catalytic residue [active] 347495001065 PAS domain; Region: PAS_9; pfam13426 347495001066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495001067 putative active site [active] 347495001068 heme pocket [chemical binding]; other site 347495001069 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 347495001070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495001071 Walker A motif; other site 347495001072 ATP binding site [chemical binding]; other site 347495001073 Walker B motif; other site 347495001074 arginine finger; other site 347495001075 succinic semialdehyde dehydrogenase; Region: PLN02278 347495001076 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 347495001077 tetramerization interface [polypeptide binding]; other site 347495001078 NAD(P) binding site [chemical binding]; other site 347495001079 catalytic residues [active] 347495001080 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 347495001081 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 347495001082 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 347495001083 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495001084 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 347495001085 putative active site [active] 347495001086 putative metal binding site [ion binding]; other site 347495001087 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495001088 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 347495001089 putative active site [active] 347495001090 putative metal binding site [ion binding]; other site 347495001091 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 347495001092 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495001093 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495001094 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 347495001095 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 347495001096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495001097 S-adenosylmethionine binding site [chemical binding]; other site 347495001098 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 347495001099 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 347495001100 FMN binding site [chemical binding]; other site 347495001101 active site 347495001102 catalytic residues [active] 347495001103 substrate binding site [chemical binding]; other site 347495001104 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 347495001105 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 347495001106 GAF domain; Region: GAF_2; pfam13185 347495001107 GAF domain; Region: GAF_3; pfam13492 347495001108 PAS fold; Region: PAS_4; pfam08448 347495001109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495001110 dimer interface [polypeptide binding]; other site 347495001111 phosphorylation site [posttranslational modification] 347495001112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001113 ATP binding site [chemical binding]; other site 347495001114 Mg2+ binding site [ion binding]; other site 347495001115 G-X-G motif; other site 347495001116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 347495001117 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 347495001118 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 347495001119 Protein of unknown function DUF45; Region: DUF45; pfam01863 347495001120 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 347495001121 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 347495001122 active site 347495001123 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 347495001124 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 347495001125 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 347495001126 metal binding site [ion binding]; metal-binding site 347495001127 putative dimer interface [polypeptide binding]; other site 347495001128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495001129 S-adenosylmethionine binding site [chemical binding]; other site 347495001130 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 347495001131 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 347495001132 catalytic residue [active] 347495001133 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 347495001134 catalytic residues [active] 347495001135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495001136 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495001137 peroxiredoxin; Region: AhpC; TIGR03137 347495001138 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 347495001139 dimer interface [polypeptide binding]; other site 347495001140 decamer (pentamer of dimers) interface [polypeptide binding]; other site 347495001141 catalytic triad [active] 347495001142 peroxidatic and resolving cysteines [active] 347495001143 5-methylribose kinase; Reviewed; Region: PRK12396 347495001144 Phosphotransferase enzyme family; Region: APH; pfam01636 347495001145 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 347495001146 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 347495001147 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 347495001148 intersubunit interface [polypeptide binding]; other site 347495001149 active site 347495001150 Zn2+ binding site [ion binding]; other site 347495001151 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495001152 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495001153 ABC-ATPase subunit interface; other site 347495001154 dimer interface [polypeptide binding]; other site 347495001155 putative PBP binding regions; other site 347495001156 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495001157 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495001158 ABC-ATPase subunit interface; other site 347495001159 dimer interface [polypeptide binding]; other site 347495001160 putative PBP binding regions; other site 347495001161 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495001162 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 347495001163 putative ligand binding residues [chemical binding]; other site 347495001164 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 347495001165 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495001166 DNA binding domain, excisionase family; Region: excise; TIGR01764 347495001167 Sm and related proteins; Region: Sm_like; cl00259 347495001168 Sm1 motif; other site 347495001169 RNA binding site [nucleotide binding]; other site 347495001170 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 347495001171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001172 ATP binding site [chemical binding]; other site 347495001173 G-X-G motif; other site 347495001174 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 347495001175 hypothetical protein; Provisional; Region: PRK06851 347495001176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 347495001177 Walker A motif; other site 347495001178 ATP binding site [chemical binding]; other site 347495001179 NTPase; Region: NTPase_1; cl17478 347495001180 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 347495001181 benzoate transport; Region: 2A0115; TIGR00895 347495001182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495001183 putative substrate translocation pore; other site 347495001184 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 347495001185 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 347495001186 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 347495001187 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 347495001188 [2Fe-2S] cluster binding site [ion binding]; other site 347495001189 Fatty acid desaturase; Region: FA_desaturase; pfam00487 347495001190 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 347495001191 putative di-iron ligands [ion binding]; other site 347495001192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495001193 dimer interface [polypeptide binding]; other site 347495001194 conserved gate region; other site 347495001195 putative PBP binding loops; other site 347495001196 ABC-ATPase subunit interface; other site 347495001197 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 347495001198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495001199 substrate binding pocket [chemical binding]; other site 347495001200 membrane-bound complex binding site; other site 347495001201 hinge residues; other site 347495001202 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 347495001203 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 347495001204 Walker A/P-loop; other site 347495001205 ATP binding site [chemical binding]; other site 347495001206 Q-loop/lid; other site 347495001207 ABC transporter signature motif; other site 347495001208 Walker B; other site 347495001209 D-loop; other site 347495001210 H-loop/switch region; other site 347495001211 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 347495001212 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 347495001213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495001214 dimerization interface [polypeptide binding]; other site 347495001215 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495001216 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495001217 dimer interface [polypeptide binding]; other site 347495001218 putative CheW interface [polypeptide binding]; other site 347495001219 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 347495001220 HAMP domain; Region: HAMP; pfam00672 347495001221 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495001222 dimer interface [polypeptide binding]; other site 347495001223 putative CheW interface [polypeptide binding]; other site 347495001224 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 347495001225 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 347495001226 Ca binding site [ion binding]; other site 347495001227 active site 347495001228 catalytic site [active] 347495001229 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 347495001230 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 347495001231 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 347495001232 active site turn [active] 347495001233 phosphorylation site [posttranslational modification] 347495001234 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 347495001235 putative catalytic site [active] 347495001236 putative metal binding site [ion binding]; other site 347495001237 putative phosphate binding site [ion binding]; other site 347495001238 Predicted membrane protein [Function unknown]; Region: COG1511 347495001239 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 347495001240 Predicted membrane protein [Function unknown]; Region: COG1511 347495001241 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 347495001242 dinuclear metal binding motif [ion binding]; other site 347495001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495001244 DNA topoisomerase III; Provisional; Region: PRK07726 347495001245 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 347495001246 active site 347495001247 putative interdomain interaction site [polypeptide binding]; other site 347495001248 putative metal-binding site [ion binding]; other site 347495001249 putative nucleotide binding site [chemical binding]; other site 347495001250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 347495001251 domain I; other site 347495001252 DNA binding groove [nucleotide binding] 347495001253 phosphate binding site [ion binding]; other site 347495001254 domain II; other site 347495001255 domain III; other site 347495001256 nucleotide binding site [chemical binding]; other site 347495001257 catalytic site [active] 347495001258 domain IV; other site 347495001259 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 347495001260 substrate binding site [chemical binding]; other site 347495001261 multimerization interface [polypeptide binding]; other site 347495001262 ATP binding site [chemical binding]; other site 347495001263 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 347495001264 thiamine phosphate binding site [chemical binding]; other site 347495001265 active site 347495001266 pyrophosphate binding site [ion binding]; other site 347495001267 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 347495001268 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 347495001269 HAMP domain; Region: HAMP; pfam00672 347495001270 dimerization interface [polypeptide binding]; other site 347495001271 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495001272 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495001273 dimer interface [polypeptide binding]; other site 347495001274 putative CheW interface [polypeptide binding]; other site 347495001275 Domain of unknown function DUF77; Region: DUF77; pfam01910 347495001276 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 347495001277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495001278 dimer interface [polypeptide binding]; other site 347495001279 conserved gate region; other site 347495001280 putative PBP binding loops; other site 347495001281 ABC-ATPase subunit interface; other site 347495001282 NMT1/THI5 like; Region: NMT1; pfam09084 347495001283 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 347495001284 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 347495001285 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 347495001286 Walker A/P-loop; other site 347495001287 ATP binding site [chemical binding]; other site 347495001288 Q-loop/lid; other site 347495001289 ABC transporter signature motif; other site 347495001290 Walker B; other site 347495001291 D-loop; other site 347495001292 H-loop/switch region; other site 347495001293 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495001294 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495001295 Walker A/P-loop; other site 347495001296 ATP binding site [chemical binding]; other site 347495001297 Q-loop/lid; other site 347495001298 ABC transporter signature motif; other site 347495001299 Walker B; other site 347495001300 D-loop; other site 347495001301 H-loop/switch region; other site 347495001302 ABC transporter; Region: ABC_tran_2; pfam12848 347495001303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495001304 Glyco_18 domain; Region: Glyco_18; smart00636 347495001305 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 347495001306 active site 347495001307 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 347495001308 Interdomain contacts; other site 347495001309 Cytokine receptor motif; other site 347495001310 CBD_II domain; Region: CBD_II; smart00637 347495001311 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 347495001312 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 347495001313 catalytic residues [active] 347495001314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495001315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495001316 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 347495001317 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495001318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495001319 putative substrate translocation pore; other site 347495001320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495001321 non-specific DNA binding site [nucleotide binding]; other site 347495001322 salt bridge; other site 347495001323 sequence-specific DNA binding site [nucleotide binding]; other site 347495001324 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 347495001325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495001326 putative substrate translocation pore; other site 347495001327 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 347495001328 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 347495001329 YesK-like protein; Region: YesK; pfam14150 347495001330 prolyl-tRNA synthetase; Provisional; Region: PRK08661 347495001331 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 347495001332 dimer interface [polypeptide binding]; other site 347495001333 motif 1; other site 347495001334 active site 347495001335 motif 2; other site 347495001336 motif 3; other site 347495001337 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 347495001338 anticodon binding site; other site 347495001339 zinc-binding site [ion binding]; other site 347495001340 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 347495001341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 347495001342 nucleotide binding site [chemical binding]; other site 347495001343 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 347495001344 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 347495001345 putative metal binding site [ion binding]; other site 347495001346 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 347495001347 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 347495001348 putative metal binding site [ion binding]; other site 347495001349 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 347495001350 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 347495001351 putative metal binding site [ion binding]; other site 347495001352 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 347495001353 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 347495001354 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 347495001355 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 347495001356 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 347495001357 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495001358 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 347495001359 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 347495001360 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 347495001361 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 347495001362 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 347495001363 Low molecular weight phosphatase family; Region: LMWPc; cd00115 347495001364 active site 347495001365 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 347495001366 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 347495001367 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 347495001368 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495001369 Soluble P-type ATPase [General function prediction only]; Region: COG4087 347495001370 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495001371 EamA-like transporter family; Region: EamA; pfam00892 347495001372 EamA-like transporter family; Region: EamA; pfam00892 347495001373 YhhN-like protein; Region: YhhN; pfam07947 347495001374 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 347495001375 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495001376 Catalytic site [active] 347495001377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495001378 binding surface 347495001379 Tetratricopeptide repeat; Region: TPR_16; pfam13432 347495001380 TPR motif; other site 347495001381 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 347495001382 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495001383 Predicted membrane protein [Function unknown]; Region: COG2510 347495001384 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 347495001385 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 347495001386 calcium/proton exchanger (cax); Region: cax; TIGR00378 347495001387 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 347495001388 YfkD-like protein; Region: YfkD; pfam14167 347495001389 Radical SAM superfamily; Region: Radical_SAM; pfam04055 347495001390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495001391 FeS/SAM binding site; other site 347495001392 YfkB-like domain; Region: YfkB; pfam08756 347495001393 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 347495001394 Fumarase C-terminus; Region: Fumerase_C; pfam05683 347495001395 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 347495001396 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 347495001397 NodB motif; other site 347495001398 active site 347495001399 catalytic site [active] 347495001400 Cd binding site [ion binding]; other site 347495001401 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 347495001402 endonuclease III; Region: ENDO3c; smart00478 347495001403 minor groove reading motif; other site 347495001404 helix-hairpin-helix signature motif; other site 347495001405 substrate binding pocket [chemical binding]; other site 347495001406 active site 347495001407 TRAM domain; Region: TRAM; pfam01938 347495001408 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 347495001409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495001410 S-adenosylmethionine binding site [chemical binding]; other site 347495001411 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 347495001412 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 347495001413 dimerization interface 3.5A [polypeptide binding]; other site 347495001414 active site 347495001415 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 347495001416 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495001417 Walker A motif; other site 347495001418 ATP binding site [chemical binding]; other site 347495001419 Walker B motif; other site 347495001420 arginine finger; other site 347495001421 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 347495001422 hypothetical protein; Validated; Region: PRK06748 347495001423 S-methylmethionine transporter; Provisional; Region: PRK11387 347495001424 acetylornithine deacetylase; Validated; Region: PRK08596 347495001425 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 347495001426 metal binding site [ion binding]; metal-binding site 347495001427 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495001428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495001429 non-specific DNA binding site [nucleotide binding]; other site 347495001430 salt bridge; other site 347495001431 sequence-specific DNA binding site [nucleotide binding]; other site 347495001432 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 347495001433 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 347495001434 Domain of unknown function DUF; Region: DUF204; pfam02659 347495001435 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 347495001436 glutaminase A; Region: Gln_ase; TIGR03814 347495001437 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 347495001438 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 347495001439 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 347495001440 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 347495001441 active site turn [active] 347495001442 phosphorylation site [posttranslational modification] 347495001443 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495001444 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495001445 Sm and related proteins; Region: Sm_like; cl00259 347495001446 heptamer interface [polypeptide binding]; other site 347495001447 Sm1 motif; other site 347495001448 hexamer interface [polypeptide binding]; other site 347495001449 RNA binding site [nucleotide binding]; other site 347495001450 Sm2 motif; other site 347495001451 Sm and related proteins; Region: Sm_like; cl00259 347495001452 heptamer interface [polypeptide binding]; other site 347495001453 Sm1 motif; other site 347495001454 hexamer interface [polypeptide binding]; other site 347495001455 RNA binding site [nucleotide binding]; other site 347495001456 Sm2 motif; other site 347495001457 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 347495001458 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 347495001459 Ligand binding site; other site 347495001460 Putative Catalytic site; other site 347495001461 DXD motif; other site 347495001462 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 347495001463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495001464 active site 347495001465 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 347495001466 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495001467 NAD(P) binding site [chemical binding]; other site 347495001468 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 347495001469 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 347495001470 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 347495001471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495001472 NAD(P) binding site [chemical binding]; other site 347495001473 active site 347495001474 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495001475 active site 347495001476 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 347495001477 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495001478 active site 347495001479 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 347495001480 Pyruvate formate lyase 1; Region: PFL1; cd01678 347495001481 coenzyme A binding site [chemical binding]; other site 347495001482 active site 347495001483 catalytic residues [active] 347495001484 glycine loop; other site 347495001485 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 347495001486 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495001487 FeS/SAM binding site; other site 347495001488 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 347495001489 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 347495001490 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 347495001491 YfhE-like protein; Region: YfhE; pfam14152 347495001492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495001493 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 347495001494 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 347495001495 active site 347495001496 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 347495001497 TIGR01777 family protein; Region: yfcH 347495001498 putative NAD(P) binding site [chemical binding]; other site 347495001499 putative active site [active] 347495001500 recombination regulator RecX; Provisional; Region: recX; PRK14135 347495001501 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 347495001502 YpzG-like protein; Region: YpzG; pfam14139 347495001503 Small acid-soluble spore protein K family; Region: SspK; pfam08176 347495001504 WVELL protein; Region: WVELL; pfam14043 347495001505 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 347495001506 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 347495001507 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 347495001508 minor groove reading motif; other site 347495001509 helix-hairpin-helix signature motif; other site 347495001510 substrate binding pocket [chemical binding]; other site 347495001511 active site 347495001512 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 347495001513 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 347495001514 DNA binding and oxoG recognition site [nucleotide binding] 347495001515 YgaB-like protein; Region: YgaB; pfam14182 347495001516 hypothetical protein; Provisional; Region: PRK13662 347495001517 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495001518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495001519 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 347495001520 Walker A/P-loop; other site 347495001521 ATP binding site [chemical binding]; other site 347495001522 Q-loop/lid; other site 347495001523 ABC transporter signature motif; other site 347495001524 Walker B; other site 347495001525 D-loop; other site 347495001526 H-loop/switch region; other site 347495001527 Predicted membrane protein [Function unknown]; Region: COG4129 347495001528 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 347495001529 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 347495001530 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 347495001531 active site 347495001532 dimer interface [polypeptide binding]; other site 347495001533 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 347495001534 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 347495001535 active site 347495001536 FMN binding site [chemical binding]; other site 347495001537 substrate binding site [chemical binding]; other site 347495001538 3Fe-4S cluster binding site [ion binding]; other site 347495001539 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 347495001540 domain_subunit interface; other site 347495001541 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 347495001542 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495001543 inhibitor-cofactor binding pocket; inhibition site 347495001544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495001545 catalytic residue [active] 347495001546 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 347495001547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495001548 Walker A/P-loop; other site 347495001549 ATP binding site [chemical binding]; other site 347495001550 Q-loop/lid; other site 347495001551 ABC transporter signature motif; other site 347495001552 Walker B; other site 347495001553 D-loop; other site 347495001554 H-loop/switch region; other site 347495001555 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 347495001556 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 347495001557 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 347495001558 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 347495001559 Ion channel; Region: Ion_trans_2; pfam07885 347495001560 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 347495001561 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 347495001562 catalytic triad [active] 347495001563 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 347495001564 metal binding site 2 [ion binding]; metal-binding site 347495001565 putative DNA binding helix; other site 347495001566 metal binding site 1 [ion binding]; metal-binding site 347495001567 dimer interface [polypeptide binding]; other site 347495001568 structural Zn2+ binding site [ion binding]; other site 347495001569 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 347495001570 hypothetical protein; Provisional; Region: PRK12378 347495001571 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 347495001572 nudix motif; other site 347495001573 thiazole/oxazole-forming peptide maturase, SagC family component; Region: cyclo_dehy_ocin; TIGR03603 347495001574 YcaO-like family; Region: YcaO; pfam02624 347495001575 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 347495001576 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 347495001577 NADPH bind site [chemical binding]; other site 347495001578 putative FMN binding site [chemical binding]; other site 347495001579 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495001580 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495001581 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495001582 Walker A/P-loop; other site 347495001583 ATP binding site [chemical binding]; other site 347495001584 Q-loop/lid; other site 347495001585 ABC transporter signature motif; other site 347495001586 Walker B; other site 347495001587 D-loop; other site 347495001588 H-loop/switch region; other site 347495001589 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 347495001590 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 347495001591 Transglycosylase; Region: Transgly; pfam00912 347495001592 Thioredoxin; Region: Thioredoxin_4; pfam13462 347495001593 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 347495001594 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 347495001595 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 347495001596 epoxyqueuosine reductase; Region: TIGR00276 347495001597 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 347495001598 Putative amidase domain; Region: Amidase_6; pfam12671 347495001599 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 347495001600 PAS fold; Region: PAS_4; pfam08448 347495001601 PAS domain S-box; Region: sensory_box; TIGR00229 347495001602 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495001603 putative active site [active] 347495001604 heme pocket [chemical binding]; other site 347495001605 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495001606 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495001607 metal binding site [ion binding]; metal-binding site 347495001608 active site 347495001609 I-site; other site 347495001610 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495001611 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 347495001612 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 347495001613 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 347495001614 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495001615 heme-binding site [chemical binding]; other site 347495001616 Leucine rich repeat; Region: LRR_8; pfam13855 347495001617 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 347495001618 Substrate binding site [chemical binding]; other site 347495001619 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495001620 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495001621 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495001622 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495001623 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 347495001624 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495001625 Leucine rich repeat; Region: LRR_8; pfam13855 347495001626 Leucine rich repeat; Region: LRR_8; pfam13855 347495001627 potential frameshift: common BLAST hit: gi|52144761|ref|YP_082067.1| acetyltransferase 347495001628 potential frameshift: common BLAST hit: gi|227816576|ref|YP_002816585.1| acetyltransferase, GNAT family 347495001629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495001630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495001631 Coenzyme A binding pocket [chemical binding]; other site 347495001632 BCCT family transporter; Region: BCCT; pfam02028 347495001633 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 347495001634 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 347495001635 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 347495001636 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 347495001637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 347495001638 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 347495001639 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 347495001640 Cache domain; Region: Cache_1; pfam02743 347495001641 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495001642 dimerization interface [polypeptide binding]; other site 347495001643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495001644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495001645 dimer interface [polypeptide binding]; other site 347495001646 putative CheW interface [polypeptide binding]; other site 347495001647 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 347495001648 PAS domain; Region: PAS; smart00091 347495001649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001650 ATP binding site [chemical binding]; other site 347495001651 Mg2+ binding site [ion binding]; other site 347495001652 G-X-G motif; other site 347495001653 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 347495001654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495001655 active site 347495001656 phosphorylation site [posttranslational modification] 347495001657 intermolecular recognition site; other site 347495001658 dimerization interface [polypeptide binding]; other site 347495001659 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 347495001660 Citrate transporter; Region: CitMHS; pfam03600 347495001661 hypothetical protein; Provisional; Region: PRK12784 347495001662 NosL; Region: NosL; cl01769 347495001663 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 347495001664 Ankyrin repeat; Region: Ank; pfam00023 347495001665 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 347495001666 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 347495001667 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 347495001668 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495001669 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 347495001670 active site 347495001671 metal binding site [ion binding]; metal-binding site 347495001672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495001673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495001674 active site 347495001675 phosphorylation site [posttranslational modification] 347495001676 intermolecular recognition site; other site 347495001677 dimerization interface [polypeptide binding]; other site 347495001678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495001679 DNA binding site [nucleotide binding] 347495001680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495001681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495001682 dimer interface [polypeptide binding]; other site 347495001683 phosphorylation site [posttranslational modification] 347495001684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001685 ATP binding site [chemical binding]; other site 347495001686 Mg2+ binding site [ion binding]; other site 347495001687 G-X-G motif; other site 347495001688 leucyl-tRNA synthetase; Reviewed; Region: leuS; PRK12300 347495001689 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 347495001690 putative active site [active] 347495001691 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 347495001692 Cache domain; Region: Cache_1; pfam02743 347495001693 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495001694 dimerization interface [polypeptide binding]; other site 347495001695 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495001696 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495001697 dimer interface [polypeptide binding]; other site 347495001698 putative CheW interface [polypeptide binding]; other site 347495001699 sensory histidine kinase DcuS; Provisional; Region: PRK11086 347495001700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001701 ATP binding site [chemical binding]; other site 347495001702 Mg2+ binding site [ion binding]; other site 347495001703 G-X-G motif; other site 347495001704 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 347495001705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495001706 active site 347495001707 phosphorylation site [posttranslational modification] 347495001708 intermolecular recognition site; other site 347495001709 dimerization interface [polypeptide binding]; other site 347495001710 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 347495001711 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 347495001712 Malic enzyme, N-terminal domain; Region: malic; pfam00390 347495001713 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 347495001714 putative NAD(P) binding site [chemical binding]; other site 347495001715 EamA-like transporter family; Region: EamA; pfam00892 347495001716 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 347495001717 EamA-like transporter family; Region: EamA; pfam00892 347495001718 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495001719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495001720 DNA-binding site [nucleotide binding]; DNA binding site 347495001721 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495001722 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495001723 homodimer interface [polypeptide binding]; other site 347495001724 catalytic residue [active] 347495001725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 347495001726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495001727 Coenzyme A binding pocket [chemical binding]; other site 347495001728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495001729 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495001730 dimerization interface [polypeptide binding]; other site 347495001731 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495001732 dimer interface [polypeptide binding]; other site 347495001733 phosphorylation site [posttranslational modification] 347495001734 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001735 ATP binding site [chemical binding]; other site 347495001736 Mg2+ binding site [ion binding]; other site 347495001737 G-X-G motif; other site 347495001738 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495001739 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495001740 active site 347495001741 phosphorylation site [posttranslational modification] 347495001742 intermolecular recognition site; other site 347495001743 dimerization interface [polypeptide binding]; other site 347495001744 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495001745 DNA binding site [nucleotide binding] 347495001746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 347495001747 Arrestin_N terminal like; Region: LDB19; pfam13002 347495001748 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495001749 Coenzyme A binding pocket [chemical binding]; other site 347495001750 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 347495001751 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 347495001752 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 347495001753 catalytic loop [active] 347495001754 iron binding site [ion binding]; other site 347495001755 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 347495001756 4Fe-4S binding domain; Region: Fer4; pfam00037 347495001757 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 347495001758 [4Fe-4S] binding site [ion binding]; other site 347495001759 molybdopterin cofactor binding site; other site 347495001760 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 347495001761 molybdopterin cofactor binding site; other site 347495001762 Uncharacterized conserved protein [Function unknown]; Region: COG2427 347495001763 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 347495001764 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 347495001765 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 347495001766 putative active site [active] 347495001767 catalytic site [active] 347495001768 putative metal binding site [ion binding]; other site 347495001769 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 347495001770 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 347495001771 hexamer interface [polypeptide binding]; other site 347495001772 ligand binding site [chemical binding]; other site 347495001773 putative active site [active] 347495001774 NAD(P) binding site [chemical binding]; other site 347495001775 amino acid transporter; Region: 2A0306; TIGR00909 347495001776 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 347495001777 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495001778 dimerization interface [polypeptide binding]; other site 347495001779 putative DNA binding site [nucleotide binding]; other site 347495001780 putative Zn2+ binding site [ion binding]; other site 347495001781 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 347495001782 metal-binding site [ion binding] 347495001783 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 347495001784 Heavy-metal-associated domain; Region: HMA; pfam00403 347495001785 metal-binding site [ion binding] 347495001786 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495001787 Soluble P-type ATPase [General function prediction only]; Region: COG4087 347495001788 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 347495001789 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 347495001790 active site 347495001791 potential frameshift: common BLAST hit: gi|118476284|ref|YP_893435.1| transcriptional activator 347495001792 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495001793 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495001794 non-specific DNA binding site [nucleotide binding]; other site 347495001795 salt bridge; other site 347495001796 sequence-specific DNA binding site [nucleotide binding]; other site 347495001797 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495001798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495001799 binding surface 347495001800 TPR motif; other site 347495001801 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495001802 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 347495001803 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495001804 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 347495001805 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 347495001806 active site 347495001807 Zn binding site [ion binding]; other site 347495001808 Uncharacterized conserved protein [Function unknown]; Region: COG0398 347495001809 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495001810 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 347495001811 VanW like protein; Region: VanW; pfam04294 347495001812 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 347495001813 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 347495001814 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495001815 Nucleoside recognition; Region: Gate; pfam07670 347495001816 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495001817 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 347495001818 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495001819 putative metal binding site [ion binding]; other site 347495001820 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 347495001821 Domain of unknown function DUF21; Region: DUF21; pfam01595 347495001822 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 347495001823 Transporter associated domain; Region: CorC_HlyC; smart01091 347495001824 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 347495001825 Aspartase; Region: Aspartase; cd01357 347495001826 active sites [active] 347495001827 tetramer interface [polypeptide binding]; other site 347495001828 L-lactate permease; Region: Lactate_perm; cl00701 347495001829 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 347495001830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495001831 dimerization interface [polypeptide binding]; other site 347495001832 putative Zn2+ binding site [ion binding]; other site 347495001833 putative DNA binding site [nucleotide binding]; other site 347495001834 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 347495001835 potential frameshift: common BLAST hit: gi|225862588|ref|YP_002747966.1| peptide transport protein, POT family 347495001836 POT family; Region: PTR2; cl17359 347495001837 POT family; Region: PTR2; cl17359 347495001838 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 347495001839 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 347495001840 siderophore binding site; other site 347495001841 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495001842 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495001843 ABC-ATPase subunit interface; other site 347495001844 dimer interface [polypeptide binding]; other site 347495001845 putative PBP binding regions; other site 347495001846 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 347495001847 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495001848 ABC-ATPase subunit interface; other site 347495001849 dimer interface [polypeptide binding]; other site 347495001850 putative PBP binding regions; other site 347495001851 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 347495001852 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 347495001853 Walker A/P-loop; other site 347495001854 ATP binding site [chemical binding]; other site 347495001855 Q-loop/lid; other site 347495001856 ABC transporter signature motif; other site 347495001857 Walker B; other site 347495001858 D-loop; other site 347495001859 H-loop/switch region; other site 347495001860 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495001861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495001862 S-adenosylmethionine binding site [chemical binding]; other site 347495001863 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 347495001864 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 347495001865 substrate-cofactor binding pocket; other site 347495001866 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495001867 catalytic residue [active] 347495001868 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 347495001869 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 347495001870 NAD binding site [chemical binding]; other site 347495001871 homodimer interface [polypeptide binding]; other site 347495001872 active site 347495001873 putative substrate binding site [chemical binding]; other site 347495001874 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 347495001875 nudix motif; other site 347495001876 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 347495001877 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 347495001878 metal ion-dependent adhesion site (MIDAS); other site 347495001879 MoxR-like ATPases [General function prediction only]; Region: COG0714 347495001880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495001881 Walker A motif; other site 347495001882 ATP binding site [chemical binding]; other site 347495001883 Walker B motif; other site 347495001884 arginine finger; other site 347495001885 cardiolipin synthetase; Reviewed; Region: PRK12452 347495001886 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 347495001887 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 347495001888 putative active site [active] 347495001889 catalytic site [active] 347495001890 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 347495001891 putative active site [active] 347495001892 catalytic site [active] 347495001893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495001894 PAS domain; Region: PAS_9; pfam13426 347495001895 putative active site [active] 347495001896 heme pocket [chemical binding]; other site 347495001897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495001898 metal binding site [ion binding]; metal-binding site 347495001899 active site 347495001900 I-site; other site 347495001901 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495001902 Amino acid permease; Region: AA_permease_2; pfam13520 347495001903 Spore germination protein; Region: Spore_permease; cl17796 347495001904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495001905 DNA-binding site [nucleotide binding]; DNA binding site 347495001906 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 347495001907 UTRA domain; Region: UTRA; pfam07702 347495001908 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 347495001909 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 347495001910 active site turn [active] 347495001911 phosphorylation site [posttranslational modification] 347495001912 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 347495001913 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 347495001914 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 347495001915 Ca binding site [ion binding]; other site 347495001916 active site 347495001917 catalytic site [active] 347495001918 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495001919 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495001920 Spore germination protein; Region: Spore_permease; cl17796 347495001921 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495001922 GAF domain; Region: GAF_3; pfam13492 347495001923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495001924 Histidine kinase; Region: HisKA_3; pfam07730 347495001925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495001926 ATP binding site [chemical binding]; other site 347495001927 Mg2+ binding site [ion binding]; other site 347495001928 G-X-G motif; other site 347495001929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495001930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495001931 active site 347495001932 phosphorylation site [posttranslational modification] 347495001933 intermolecular recognition site; other site 347495001934 dimerization interface [polypeptide binding]; other site 347495001935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495001936 DNA binding residues [nucleotide binding] 347495001937 dimerization interface [polypeptide binding]; other site 347495001938 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 347495001939 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 347495001940 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 347495001941 putative active site [active] 347495001942 catalytic triad [active] 347495001943 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 347495001944 PA/protease domain interface [polypeptide binding]; other site 347495001945 putative integrin binding motif; other site 347495001946 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 347495001947 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 347495001948 dockerin binding interface; other site 347495001949 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 347495001950 potential frameshift: common BLAST hit: gi|301052290|ref|YP_003790501.1| CAAX amino terminal protease 347495001951 CAAX protease self-immunity; Region: Abi; pfam02517 347495001952 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495001953 active site 347495001954 ATP binding site [chemical binding]; other site 347495001955 substrate binding site [chemical binding]; other site 347495001956 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495001957 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 347495001958 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 347495001959 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 347495001960 Walker A/P-loop; other site 347495001961 ATP binding site [chemical binding]; other site 347495001962 Q-loop/lid; other site 347495001963 ABC transporter signature motif; other site 347495001964 Walker B; other site 347495001965 D-loop; other site 347495001966 H-loop/switch region; other site 347495001967 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 347495001968 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495001969 substrate binding pocket [chemical binding]; other site 347495001970 membrane-bound complex binding site; other site 347495001971 hinge residues; other site 347495001972 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 347495001973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495001974 dimer interface [polypeptide binding]; other site 347495001975 conserved gate region; other site 347495001976 putative PBP binding loops; other site 347495001977 ABC-ATPase subunit interface; other site 347495001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495001979 dimer interface [polypeptide binding]; other site 347495001980 conserved gate region; other site 347495001981 putative PBP binding loops; other site 347495001982 ABC-ATPase subunit interface; other site 347495001983 S-methylmethionine transporter; Provisional; Region: PRK11387 347495001984 OsmC-like protein; Region: OsmC; pfam02566 347495001985 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 347495001986 nucleotide binding site/active site [active] 347495001987 HIT family signature motif; other site 347495001988 catalytic residue [active] 347495001989 RNA polymerase sigma factor; Provisional; Region: PRK12542 347495001990 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495001991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495001992 DNA binding residues [nucleotide binding] 347495001993 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 347495001994 Predicted transcriptional regulator [Transcription]; Region: COG2378 347495001995 HTH domain; Region: HTH_11; pfam08279 347495001996 WYL domain; Region: WYL; pfam13280 347495001997 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 347495001998 RibD C-terminal domain; Region: RibD_C; cl17279 347495001999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495002000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495002001 dimerization interface [polypeptide binding]; other site 347495002002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495002003 dimer interface [polypeptide binding]; other site 347495002004 phosphorylation site [posttranslational modification] 347495002005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495002006 ATP binding site [chemical binding]; other site 347495002007 Mg2+ binding site [ion binding]; other site 347495002008 G-X-G motif; other site 347495002009 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495002010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495002011 active site 347495002012 phosphorylation site [posttranslational modification] 347495002013 intermolecular recognition site; other site 347495002014 dimerization interface [polypeptide binding]; other site 347495002015 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495002016 DNA binding site [nucleotide binding] 347495002017 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 347495002018 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 347495002019 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 347495002020 Sulfate transporter family; Region: Sulfate_transp; pfam00916 347495002021 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 347495002022 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 347495002023 Ligand Binding Site [chemical binding]; other site 347495002024 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 347495002025 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 347495002026 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 347495002027 peptide binding site [polypeptide binding]; other site 347495002028 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 347495002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002030 dimer interface [polypeptide binding]; other site 347495002031 conserved gate region; other site 347495002032 putative PBP binding loops; other site 347495002033 ABC-ATPase subunit interface; other site 347495002034 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495002035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002036 putative PBP binding loops; other site 347495002037 ABC-ATPase subunit interface; other site 347495002038 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 347495002039 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495002040 Walker A/P-loop; other site 347495002041 ATP binding site [chemical binding]; other site 347495002042 Q-loop/lid; other site 347495002043 ABC transporter signature motif; other site 347495002044 Walker B; other site 347495002045 D-loop; other site 347495002046 H-loop/switch region; other site 347495002047 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 347495002048 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 347495002049 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495002050 Walker A/P-loop; other site 347495002051 ATP binding site [chemical binding]; other site 347495002052 Q-loop/lid; other site 347495002053 ABC transporter signature motif; other site 347495002054 Walker B; other site 347495002055 D-loop; other site 347495002056 H-loop/switch region; other site 347495002057 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 347495002058 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 347495002059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002060 putative substrate translocation pore; other site 347495002061 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495002062 MarR family; Region: MarR; pfam01047 347495002063 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495002064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002065 putative substrate translocation pore; other site 347495002066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495002067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495002068 DNA binding site [nucleotide binding] 347495002069 domain linker motif; other site 347495002070 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 347495002071 dimerization interface [polypeptide binding]; other site 347495002072 ligand binding site [chemical binding]; other site 347495002073 sodium binding site [ion binding]; other site 347495002074 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 347495002075 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 347495002076 substrate binding site [chemical binding]; other site 347495002077 dimer interface [polypeptide binding]; other site 347495002078 ATP binding site [chemical binding]; other site 347495002079 D-ribose pyranase; Provisional; Region: PRK11797 347495002080 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 347495002081 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 347495002082 Walker A/P-loop; other site 347495002083 ATP binding site [chemical binding]; other site 347495002084 Q-loop/lid; other site 347495002085 ABC transporter signature motif; other site 347495002086 Walker B; other site 347495002087 D-loop; other site 347495002088 H-loop/switch region; other site 347495002089 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 347495002090 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 347495002091 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 347495002092 TM-ABC transporter signature motif; other site 347495002093 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 347495002094 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 347495002095 ligand binding site [chemical binding]; other site 347495002096 dimerization interface [polypeptide binding]; other site 347495002097 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 347495002098 active site 347495002099 intersubunit interactions; other site 347495002100 catalytic residue [active] 347495002101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 347495002102 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 347495002103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002104 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495002105 putative substrate translocation pore; other site 347495002106 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 347495002107 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 347495002108 putative NAD(P) binding site [chemical binding]; other site 347495002109 catalytic Zn binding site [ion binding]; other site 347495002110 Ion channel; Region: Ion_trans_2; pfam07885 347495002111 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 347495002112 Zn binding site [ion binding]; other site 347495002113 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 347495002114 putative catalytic site [active] 347495002115 metal binding site A [ion binding]; metal-binding site 347495002116 phosphate binding site [ion binding]; other site 347495002117 metal binding site C [ion binding]; metal-binding site 347495002118 metal binding site B [ion binding]; metal-binding site 347495002119 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 347495002120 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 347495002121 dimer interface [polypeptide binding]; other site 347495002122 active site 347495002123 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 347495002124 substrate binding site [chemical binding]; other site 347495002125 catalytic residue [active] 347495002126 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 347495002127 FAD binding domain; Region: FAD_binding_4; pfam01565 347495002128 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 347495002129 VanZ like family; Region: VanZ; pfam04892 347495002130 RDD family; Region: RDD; pfam06271 347495002131 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 347495002132 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495002133 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495002134 dimer interface [polypeptide binding]; other site 347495002135 putative CheW interface [polypeptide binding]; other site 347495002136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 347495002137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 347495002138 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495002139 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495002140 non-specific DNA binding site [nucleotide binding]; other site 347495002141 salt bridge; other site 347495002142 sequence-specific DNA binding site [nucleotide binding]; other site 347495002143 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 347495002144 active site 347495002145 catalytic site [active] 347495002146 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 347495002147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002148 putative substrate translocation pore; other site 347495002149 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 347495002150 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 347495002151 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 347495002152 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 347495002153 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 347495002154 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 347495002155 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495002156 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495002157 non-specific DNA binding site [nucleotide binding]; other site 347495002158 salt bridge; other site 347495002159 sequence-specific DNA binding site [nucleotide binding]; other site 347495002160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495002161 Coenzyme A binding pocket [chemical binding]; other site 347495002162 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 347495002163 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 347495002164 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 347495002165 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 347495002166 TrkA-N domain; Region: TrkA_N; pfam02254 347495002167 TrkA-C domain; Region: TrkA_C; pfam02080 347495002168 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 347495002169 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 347495002170 Subunit I/III interface [polypeptide binding]; other site 347495002171 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 347495002172 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 347495002173 D-pathway; other site 347495002174 Putative ubiquinol binding site [chemical binding]; other site 347495002175 Low-spin heme (heme b) binding site [chemical binding]; other site 347495002176 Putative water exit pathway; other site 347495002177 Binuclear center (heme o3/CuB) [ion binding]; other site 347495002178 K-pathway; other site 347495002179 Putative proton exit pathway; other site 347495002180 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 347495002181 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 347495002182 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 347495002183 putative active site [active] 347495002184 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 347495002185 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 347495002186 metal binding site [ion binding]; metal-binding site 347495002187 dimer interface [polypeptide binding]; other site 347495002188 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 347495002189 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 347495002190 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 347495002191 Na binding site [ion binding]; other site 347495002192 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495002193 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 347495002194 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495002195 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495002196 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 347495002197 Nucleoside recognition; Region: Gate; pfam07670 347495002198 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 347495002199 Nucleoside recognition; Region: Gate; pfam07670 347495002200 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 347495002201 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 347495002202 G1 box; other site 347495002203 GTP/Mg2+ binding site [chemical binding]; other site 347495002204 Switch I region; other site 347495002205 G2 box; other site 347495002206 G3 box; other site 347495002207 Switch II region; other site 347495002208 G4 box; other site 347495002209 G5 box; other site 347495002210 FeoA domain; Region: FeoA; pfam04023 347495002211 phosphate binding protein; Region: ptsS_2; TIGR02136 347495002212 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 347495002213 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 347495002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002215 dimer interface [polypeptide binding]; other site 347495002216 conserved gate region; other site 347495002217 putative PBP binding loops; other site 347495002218 ABC-ATPase subunit interface; other site 347495002219 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 347495002220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002221 dimer interface [polypeptide binding]; other site 347495002222 conserved gate region; other site 347495002223 putative PBP binding loops; other site 347495002224 ABC-ATPase subunit interface; other site 347495002225 AAA domain; Region: AAA_33; pfam13671 347495002226 AAA domain; Region: AAA_17; pfam13207 347495002227 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 347495002228 FOG: CBS domain [General function prediction only]; Region: COG0517 347495002229 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 347495002230 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 347495002231 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 347495002232 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495002233 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495002234 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495002235 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495002236 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495002237 Putative transcription activator [Transcription]; Region: TenA; COG0819 347495002238 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 347495002239 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 347495002240 Walker A/P-loop; other site 347495002241 ATP binding site [chemical binding]; other site 347495002242 Q-loop/lid; other site 347495002243 ABC transporter signature motif; other site 347495002244 Walker B; other site 347495002245 D-loop; other site 347495002246 H-loop/switch region; other site 347495002247 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 347495002248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002249 dimer interface [polypeptide binding]; other site 347495002250 conserved gate region; other site 347495002251 putative PBP binding loops; other site 347495002252 ABC-ATPase subunit interface; other site 347495002253 NMT1/THI5 like; Region: NMT1; pfam09084 347495002254 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 347495002255 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 347495002256 thiamine phosphate binding site [chemical binding]; other site 347495002257 active site 347495002258 pyrophosphate binding site [ion binding]; other site 347495002259 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 347495002260 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 347495002261 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 347495002262 thiS-thiF/thiG interaction site; other site 347495002263 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 347495002264 ThiS interaction site; other site 347495002265 putative active site [active] 347495002266 tetramer interface [polypeptide binding]; other site 347495002267 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 347495002268 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 347495002269 ATP binding site [chemical binding]; other site 347495002270 substrate interface [chemical binding]; other site 347495002271 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 347495002272 dimer interface [polypeptide binding]; other site 347495002273 substrate binding site [chemical binding]; other site 347495002274 ATP binding site [chemical binding]; other site 347495002275 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 347495002276 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 347495002277 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495002278 Soluble P-type ATPase [General function prediction only]; Region: COG4087 347495002279 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 347495002280 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 347495002281 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 347495002282 Ligand Binding Site [chemical binding]; other site 347495002283 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 347495002284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002285 putative substrate translocation pore; other site 347495002286 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495002287 MarR family; Region: MarR; pfam01047 347495002288 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 347495002289 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 347495002290 active site 347495002291 nucleophile elbow; other site 347495002292 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495002293 FtsX-like permease family; Region: FtsX; pfam02687 347495002294 FtsX-like permease family; Region: FtsX; pfam02687 347495002295 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495002296 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495002297 Walker A/P-loop; other site 347495002298 ATP binding site [chemical binding]; other site 347495002299 Q-loop/lid; other site 347495002300 ABC transporter signature motif; other site 347495002301 Walker B; other site 347495002302 D-loop; other site 347495002303 H-loop/switch region; other site 347495002304 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 347495002305 short chain dehydrogenase; Provisional; Region: PRK06701 347495002306 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 347495002307 NAD binding site [chemical binding]; other site 347495002308 metal binding site [ion binding]; metal-binding site 347495002309 active site 347495002310 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 347495002311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 347495002312 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 347495002313 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 347495002314 putative substrate binding site [chemical binding]; other site 347495002315 putative ATP binding site [chemical binding]; other site 347495002316 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 347495002317 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 347495002318 substrate binding [chemical binding]; other site 347495002319 active site 347495002320 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 347495002321 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 347495002322 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 347495002323 active site turn [active] 347495002324 phosphorylation site [posttranslational modification] 347495002325 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 347495002326 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495002327 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495002328 DNA binding site [nucleotide binding] 347495002329 domain linker motif; other site 347495002330 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 347495002331 dimerization interface [polypeptide binding]; other site 347495002332 ligand binding site [chemical binding]; other site 347495002333 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 347495002334 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 347495002335 catalytic residues [active] 347495002336 putative disulfide oxidoreductase; Provisional; Region: PRK03113 347495002337 YhdB-like protein; Region: YhdB; pfam14148 347495002338 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 347495002339 Spore germination protein; Region: Spore_permease; pfam03845 347495002340 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495002341 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495002342 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495002343 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 347495002344 putative FMN binding site [chemical binding]; other site 347495002345 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 347495002346 SpoVR like protein; Region: SpoVR; pfam04293 347495002347 Part of AAA domain; Region: AAA_19; pfam13245 347495002348 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 347495002349 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 347495002350 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 347495002351 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495002352 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495002353 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 347495002354 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 347495002355 active site residue [active] 347495002356 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 347495002357 putative homodimer interface [polypeptide binding]; other site 347495002358 putative homotetramer interface [polypeptide binding]; other site 347495002359 putative metal binding site [ion binding]; other site 347495002360 putative homodimer-homodimer interface [polypeptide binding]; other site 347495002361 putative allosteric switch controlling residues; other site 347495002362 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 347495002363 CPxP motif; other site 347495002364 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495002365 active site residue [active] 347495002366 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 347495002367 active site residue [active] 347495002368 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495002369 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 347495002370 CPxP motif; other site 347495002371 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495002372 active site residue [active] 347495002373 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495002374 active site residue [active] 347495002375 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 347495002376 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495002377 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 347495002378 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 347495002379 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 347495002380 NADP binding site [chemical binding]; other site 347495002381 dimer interface [polypeptide binding]; other site 347495002382 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 347495002383 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 347495002384 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 347495002385 PhoU domain; Region: PhoU; pfam01895 347495002386 PhoU domain; Region: PhoU; pfam01895 347495002387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495002389 putative substrate translocation pore; other site 347495002390 Uncharacterized conserved protein [Function unknown]; Region: COG3589 347495002391 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 347495002392 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 347495002393 HTH domain; Region: HTH_11; pfam08279 347495002394 Mga helix-turn-helix domain; Region: Mga; pfam05043 347495002395 PRD domain; Region: PRD; pfam00874 347495002396 PRD domain; Region: PRD; pfam00874 347495002397 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 347495002398 active site 347495002399 P-loop; other site 347495002400 phosphorylation site [posttranslational modification] 347495002401 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 347495002402 active site 347495002403 phosphorylation site [posttranslational modification] 347495002404 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 347495002405 active site 347495002406 methionine cluster; other site 347495002407 phosphorylation site [posttranslational modification] 347495002408 metal binding site [ion binding]; metal-binding site 347495002409 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 347495002410 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 347495002411 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 347495002412 Uncharacterized conserved protein [Function unknown]; Region: COG3589 347495002413 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 347495002414 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495002415 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495002416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 347495002417 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 347495002418 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495002419 FtsX-like permease family; Region: FtsX; pfam02687 347495002420 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495002421 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495002422 Walker A/P-loop; other site 347495002423 ATP binding site [chemical binding]; other site 347495002424 Q-loop/lid; other site 347495002425 ABC transporter signature motif; other site 347495002426 Walker B; other site 347495002427 D-loop; other site 347495002428 H-loop/switch region; other site 347495002429 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 347495002430 HlyD family secretion protein; Region: HlyD_3; pfam13437 347495002431 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 347495002432 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 347495002433 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495002434 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 347495002435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002436 dimer interface [polypeptide binding]; other site 347495002437 conserved gate region; other site 347495002438 ABC-ATPase subunit interface; other site 347495002439 FtsX-like permease family; Region: FtsX; pfam02687 347495002440 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495002441 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 347495002442 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 347495002443 dimanganese center [ion binding]; other site 347495002444 CotJB protein; Region: CotJB; pfam12652 347495002445 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 347495002446 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495002447 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495002448 active site 347495002449 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 347495002450 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 347495002451 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 347495002452 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 347495002453 putative DNA binding site [nucleotide binding]; other site 347495002454 putative homodimer interface [polypeptide binding]; other site 347495002455 Uncharacterized conserved protein [Function unknown]; Region: COG3339 347495002456 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 347495002457 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495002458 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 347495002459 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 347495002460 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 347495002461 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495002462 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 347495002463 active site 347495002464 metal binding site [ion binding]; metal-binding site 347495002465 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 347495002466 Interdomain contacts; other site 347495002467 Cytokine receptor motif; other site 347495002468 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 347495002469 amino acid transporter; Region: 2A0306; TIGR00909 347495002470 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 347495002471 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 347495002472 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 347495002473 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 347495002474 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 347495002475 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 347495002476 putative active site [active] 347495002477 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 347495002478 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 347495002479 putative active site [active] 347495002480 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 347495002481 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 347495002482 active site turn [active] 347495002483 phosphorylation site [posttranslational modification] 347495002484 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 347495002485 Probable transposase; Region: OrfB_IS605; pfam01385 347495002486 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 347495002487 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 347495002488 Uncharacterized conserved protein [Function unknown]; Region: COG3589 347495002489 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 347495002490 DoxX; Region: DoxX; pfam07681 347495002491 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 347495002492 hypothetical protein; Provisional; Region: PRK06770 347495002493 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495002494 EamA-like transporter family; Region: EamA; pfam00892 347495002495 EamA-like transporter family; Region: EamA; pfam00892 347495002496 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 347495002497 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 347495002498 AsnC family; Region: AsnC_trans_reg; pfam01037 347495002499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495002500 Coenzyme A binding pocket [chemical binding]; other site 347495002501 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 347495002502 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 347495002503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495002504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495002505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495002507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002508 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 347495002509 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 347495002510 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 347495002511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495002512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002513 putative substrate translocation pore; other site 347495002514 intracellular protease, PfpI family; Region: PfpI; TIGR01382 347495002515 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 347495002516 proposed catalytic triad [active] 347495002517 conserved cys residue [active] 347495002518 hydroperoxidase II; Provisional; Region: katE; PRK11249 347495002519 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 347495002520 tetramer interface [polypeptide binding]; other site 347495002521 heme binding pocket [chemical binding]; other site 347495002522 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 347495002523 domain interactions; other site 347495002524 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 347495002525 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 347495002526 Spore germination protein; Region: Spore_permease; cl17796 347495002527 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 347495002528 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 347495002529 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 347495002530 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 347495002531 tetrameric interface [polypeptide binding]; other site 347495002532 activator binding site; other site 347495002533 NADP binding site [chemical binding]; other site 347495002534 substrate binding site [chemical binding]; other site 347495002535 catalytic residues [active] 347495002536 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495002537 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 347495002538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495002539 Walker A/P-loop; other site 347495002540 ATP binding site [chemical binding]; other site 347495002541 Q-loop/lid; other site 347495002542 ABC transporter signature motif; other site 347495002543 Walker B; other site 347495002544 D-loop; other site 347495002545 H-loop/switch region; other site 347495002546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495002547 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 347495002548 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 347495002549 Walker A/P-loop; other site 347495002550 ATP binding site [chemical binding]; other site 347495002551 Q-loop/lid; other site 347495002552 ABC transporter signature motif; other site 347495002553 Walker B; other site 347495002554 D-loop; other site 347495002555 H-loop/switch region; other site 347495002556 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 347495002557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495002558 substrate binding pocket [chemical binding]; other site 347495002559 membrane-bound complex binding site; other site 347495002560 hinge residues; other site 347495002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495002562 dimer interface [polypeptide binding]; other site 347495002563 conserved gate region; other site 347495002564 putative PBP binding loops; other site 347495002565 ABC-ATPase subunit interface; other site 347495002566 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 347495002567 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 347495002568 Walker A/P-loop; other site 347495002569 ATP binding site [chemical binding]; other site 347495002570 Q-loop/lid; other site 347495002571 ABC transporter signature motif; other site 347495002572 Walker B; other site 347495002573 D-loop; other site 347495002574 H-loop/switch region; other site 347495002575 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495002576 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 347495002577 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 347495002578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 347495002579 hypothetical protein; Provisional; Region: PRK13676 347495002580 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 347495002581 acetolactate synthase; Reviewed; Region: PRK08617 347495002582 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 347495002583 PYR/PP interface [polypeptide binding]; other site 347495002584 dimer interface [polypeptide binding]; other site 347495002585 TPP binding site [chemical binding]; other site 347495002586 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 347495002587 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 347495002588 TPP-binding site [chemical binding]; other site 347495002589 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 347495002590 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 347495002591 active site 347495002592 DNA binding site [nucleotide binding] 347495002593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 347495002594 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495002595 active site 347495002596 motif I; other site 347495002597 motif II; other site 347495002598 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 347495002599 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 347495002600 amidase catalytic site [active] 347495002601 Zn binding residues [ion binding]; other site 347495002602 substrate binding site [chemical binding]; other site 347495002603 S-layer homology domain; Region: SLH; pfam00395 347495002604 S-layer homology domain; Region: SLH; pfam00395 347495002605 S-layer homology domain; Region: SLH; pfam00395 347495002606 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 347495002607 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 347495002608 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495002609 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 347495002610 acyl-activating enzyme (AAE) consensus motif; other site 347495002611 acyl-activating enzyme (AAE) consensus motif; other site 347495002612 putative AMP binding site [chemical binding]; other site 347495002613 putative active site [active] 347495002614 putative CoA binding site [chemical binding]; other site 347495002615 high affinity sulphate transporter 1; Region: sulP; TIGR00815 347495002616 Sulfate transporter family; Region: Sulfate_transp; pfam00916 347495002617 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 347495002618 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 347495002619 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 347495002620 ATP binding site [chemical binding]; other site 347495002621 putative Mg++ binding site [ion binding]; other site 347495002622 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 347495002623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495002624 nucleotide binding region [chemical binding]; other site 347495002625 ATP-binding site [chemical binding]; other site 347495002626 stage V sporulation protein B; Region: spore_V_B; TIGR02900 347495002627 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 347495002628 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 347495002629 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 347495002630 S-layer homology domain; Region: SLH; pfam00395 347495002631 S-layer homology domain; Region: SLH; pfam00395 347495002632 S-layer homology domain; Region: SLH; pfam00395 347495002633 S-layer homology domain; Region: SLH; pfam00395 347495002634 S-layer homology domain; Region: SLH; pfam00395 347495002635 S-layer homology domain; Region: SLH; pfam00395 347495002636 DHHW protein; Region: DHHW; pfam14286 347495002637 DHHW protein; Region: DHHW; pfam14286 347495002638 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 347495002639 enoyl-CoA hydratase; Provisional; Region: PRK07659 347495002640 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495002641 substrate binding site [chemical binding]; other site 347495002642 oxyanion hole (OAH) forming residues; other site 347495002643 trimer interface [polypeptide binding]; other site 347495002644 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 347495002645 metal binding site [ion binding]; metal-binding site 347495002646 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 347495002647 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 347495002648 putative oligomer interface [polypeptide binding]; other site 347495002649 putative active site [active] 347495002650 metal binding site [ion binding]; metal-binding site 347495002651 S-layer homology domain; Region: SLH; pfam00395 347495002652 S-layer homology domain; Region: SLH; pfam00395 347495002653 S-layer homology domain; Region: SLH; pfam00395 347495002654 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 347495002655 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 347495002656 active site 347495002657 metal binding site [ion binding]; metal-binding site 347495002658 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 347495002659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495002660 S-adenosylmethionine binding site [chemical binding]; other site 347495002661 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 347495002662 potential frameshift: common BLAST hit: gi|225862863|ref|YP_002748241.1| putative proline racemase 347495002663 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 347495002664 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 347495002665 ornithine cyclodeaminase; Validated; Region: PRK08618 347495002666 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 347495002667 NAD(P) binding site [chemical binding]; other site 347495002668 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 347495002669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002670 putative substrate translocation pore; other site 347495002671 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 347495002672 PAS domain; Region: PAS; smart00091 347495002673 putative active site [active] 347495002674 heme pocket [chemical binding]; other site 347495002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495002676 ATP binding site [chemical binding]; other site 347495002677 Mg2+ binding site [ion binding]; other site 347495002678 G-X-G motif; other site 347495002679 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 347495002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495002681 active site 347495002682 phosphorylation site [posttranslational modification] 347495002683 intermolecular recognition site; other site 347495002684 dimerization interface [polypeptide binding]; other site 347495002685 HTH domain; Region: HTH_11; cl17392 347495002686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 347495002687 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 347495002688 Predicted transcriptional regulator [Transcription]; Region: COG2378 347495002689 HTH domain; Region: HTH_11; pfam08279 347495002690 WYL domain; Region: WYL; pfam13280 347495002691 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 347495002692 putative active site [active] 347495002693 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 347495002694 putative active site [active] 347495002695 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 347495002696 putative active site [active] 347495002697 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 347495002698 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 347495002699 cofactor binding site; other site 347495002700 DNA binding site [nucleotide binding] 347495002701 substrate interaction site [chemical binding]; other site 347495002702 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 347495002703 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 347495002704 DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238 347495002705 DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236 347495002706 DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237 347495002707 Domain of unknown function DUF87; Region: DUF87; pfam01935 347495002708 AAA-like domain; Region: AAA_10; pfam12846 347495002709 Tic20-like protein; Region: Tic20; pfam09685 347495002710 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 347495002711 DNA binding residues [nucleotide binding] 347495002712 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495002713 dimer interface [polypeptide binding]; other site 347495002714 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 347495002715 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 347495002716 replicative DNA helicase; Provisional; Region: PRK06749 347495002717 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 347495002718 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 347495002719 Walker A motif; other site 347495002720 ATP binding site [chemical binding]; other site 347495002721 Walker B motif; other site 347495002722 DNA binding loops [nucleotide binding] 347495002723 Predicted transcriptional regulators [Transcription]; Region: COG1378 347495002724 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 347495002725 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 347495002726 C-terminal domain interface [polypeptide binding]; other site 347495002727 sugar binding site [chemical binding]; other site 347495002728 hypothetical protein; Provisional; Region: PRK10621 347495002729 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495002730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495002731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495002732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002733 putative substrate translocation pore; other site 347495002734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002735 Predicted permease; Region: DUF318; cl17795 347495002736 Predicted permease; Region: DUF318; cl17795 347495002737 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495002738 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495002739 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 347495002740 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 347495002741 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 347495002742 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 347495002743 CGNR zinc finger; Region: zf-CGNR; pfam11706 347495002744 HPP family; Region: HPP; pfam04982 347495002745 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 347495002746 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 347495002747 putative NAD(P) binding site [chemical binding]; other site 347495002748 active site 347495002749 putative substrate binding site [chemical binding]; other site 347495002750 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495002751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495002752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495002753 YmzC-like protein; Region: YmzC; pfam14157 347495002754 Transcriptional regulators [Transcription]; Region: MarR; COG1846 347495002755 MarR family; Region: MarR_2; pfam12802 347495002756 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 347495002757 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 347495002758 ATP synthase I chain; Region: ATP_synt_I; pfam03899 347495002759 VanZ like family; Region: VanZ; pfam04892 347495002760 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 347495002761 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 347495002762 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 347495002763 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 347495002764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495002765 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 347495002766 dihydroxyacetone kinase; Provisional; Region: PRK14479 347495002767 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 347495002768 DAK2 domain; Region: Dak2; pfam02734 347495002769 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 347495002770 Predicted transcriptional regulator [Transcription]; Region: COG1959 347495002771 Transcriptional regulator; Region: Rrf2; pfam02082 347495002772 DAK2 domain; Region: Dak2; pfam02734 347495002773 Bacterial SH3 domain; Region: SH3_3; cl17532 347495002774 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495002775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495002776 TPR motif; other site 347495002777 binding surface 347495002778 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 347495002779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495002780 Zn2+ binding site [ion binding]; other site 347495002781 Mg2+ binding site [ion binding]; other site 347495002782 S-layer homology domain; Region: SLH; pfam00395 347495002783 S-layer homology domain; Region: SLH; pfam00395 347495002784 S-layer homology domain; Region: SLH; pfam00395 347495002785 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 347495002786 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495002787 Transcriptional regulator PadR-like family; Region: PadR; cl17335 347495002788 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 347495002789 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 347495002790 Heat induced stress protein YflT; Region: YflT; pfam11181 347495002791 CsbD-like; Region: CsbD; pfam05532 347495002792 Predicted membrane protein [Function unknown]; Region: COG2261 347495002793 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 347495002794 anti sigma factor interaction site; other site 347495002795 regulatory phosphorylation site [posttranslational modification]; other site 347495002796 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 347495002797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495002798 ATP binding site [chemical binding]; other site 347495002799 Mg2+ binding site [ion binding]; other site 347495002800 G-X-G motif; other site 347495002801 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 347495002802 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495002803 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 347495002804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495002805 DNA binding residues [nucleotide binding] 347495002806 Ferritin-like domain; Region: Ferritin; pfam00210 347495002807 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 347495002808 dinuclear metal binding motif [ion binding]; other site 347495002809 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 347495002810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495002811 active site 347495002812 phosphorylation site [posttranslational modification] 347495002813 intermolecular recognition site; other site 347495002814 dimerization interface [polypeptide binding]; other site 347495002815 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 347495002816 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 347495002817 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 347495002818 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 347495002819 CHASE3 domain; Region: CHASE3; pfam05227 347495002820 GAF domain; Region: GAF; pfam01590 347495002821 GAF domain; Region: GAF_2; pfam13185 347495002822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495002823 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495002824 dimer interface [polypeptide binding]; other site 347495002825 phosphorylation site [posttranslational modification] 347495002826 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495002827 ATP binding site [chemical binding]; other site 347495002828 Mg2+ binding site [ion binding]; other site 347495002829 G-X-G motif; other site 347495002830 Response regulator receiver domain; Region: Response_reg; pfam00072 347495002831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495002832 active site 347495002833 phosphorylation site [posttranslational modification] 347495002834 intermolecular recognition site; other site 347495002835 dimerization interface [polypeptide binding]; other site 347495002836 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 347495002837 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 347495002838 hypothetical protein; Provisional; Region: PRK12856 347495002839 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495002840 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 347495002841 NADP binding site [chemical binding]; other site 347495002842 dimer interface [polypeptide binding]; other site 347495002843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495002844 Histidine kinase; Region: HisKA_3; pfam07730 347495002845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495002846 ATP binding site [chemical binding]; other site 347495002847 Mg2+ binding site [ion binding]; other site 347495002848 G-X-G motif; other site 347495002849 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495002850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495002851 active site 347495002852 phosphorylation site [posttranslational modification] 347495002853 intermolecular recognition site; other site 347495002854 dimerization interface [polypeptide binding]; other site 347495002855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495002856 DNA binding residues [nucleotide binding] 347495002857 dimerization interface [polypeptide binding]; other site 347495002858 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 347495002859 YhzD-like protein; Region: YhzD; pfam14120 347495002860 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 347495002861 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495002862 active site 347495002863 metal binding site [ion binding]; metal-binding site 347495002864 DNA binding site [nucleotide binding] 347495002865 AAA domain; Region: AAA_27; pfam13514 347495002866 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495002867 Q-loop/lid; other site 347495002868 ABC transporter signature motif; other site 347495002869 Walker B; other site 347495002870 D-loop; other site 347495002871 H-loop/switch region; other site 347495002872 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 347495002873 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 347495002874 generic binding surface I; other site 347495002875 generic binding surface II; other site 347495002876 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495002877 Zn2+ binding site [ion binding]; other site 347495002878 Mg2+ binding site [ion binding]; other site 347495002879 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 347495002880 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 347495002881 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 347495002882 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495002883 Zn binding site [ion binding]; other site 347495002884 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 347495002885 Zn binding site [ion binding]; other site 347495002886 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 347495002887 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495002888 Zn binding site [ion binding]; other site 347495002889 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 347495002890 Zn binding site [ion binding]; other site 347495002891 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 347495002892 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 347495002893 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 347495002894 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 347495002895 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 347495002896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495002897 non-specific DNA binding site [nucleotide binding]; other site 347495002898 salt bridge; other site 347495002899 sequence-specific DNA binding site [nucleotide binding]; other site 347495002900 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 347495002901 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 347495002902 amphipathic channel; other site 347495002903 Asn-Pro-Ala signature motifs; other site 347495002904 glycerol kinase; Provisional; Region: glpK; PRK00047 347495002905 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 347495002906 N- and C-terminal domain interface [polypeptide binding]; other site 347495002907 active site 347495002908 MgATP binding site [chemical binding]; other site 347495002909 catalytic site [active] 347495002910 metal binding site [ion binding]; metal-binding site 347495002911 glycerol binding site [chemical binding]; other site 347495002912 homotetramer interface [polypeptide binding]; other site 347495002913 homodimer interface [polypeptide binding]; other site 347495002914 FBP binding site [chemical binding]; other site 347495002915 protein IIAGlc interface [polypeptide binding]; other site 347495002916 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 347495002917 Protein of unknown function (DUF2283); Region: DUF2283; pfam10049 347495002918 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 347495002919 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495002920 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495002921 DNA binding residues [nucleotide binding] 347495002922 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 347495002923 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495002924 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 347495002925 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495002926 MarR family; Region: MarR; pfam01047 347495002927 DoxX-like family; Region: DoxX_2; pfam13564 347495002928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002929 putative substrate translocation pore; other site 347495002930 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495002931 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495002932 putative substrate translocation pore; other site 347495002933 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 347495002934 Part of AAA domain; Region: AAA_19; pfam13245 347495002935 Family description; Region: UvrD_C_2; pfam13538 347495002936 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 347495002937 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 347495002938 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 347495002939 transcriptional regulator Hpr; Provisional; Region: PRK13777 347495002940 MarR family; Region: MarR; pfam01047 347495002941 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 347495002942 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 347495002943 HIT family signature motif; other site 347495002944 catalytic residue [active] 347495002945 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 347495002946 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495002947 Walker A/P-loop; other site 347495002948 ATP binding site [chemical binding]; other site 347495002949 Q-loop/lid; other site 347495002950 ABC transporter signature motif; other site 347495002951 Walker B; other site 347495002952 D-loop; other site 347495002953 H-loop/switch region; other site 347495002954 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 347495002955 EcsC protein family; Region: EcsC; pfam12787 347495002956 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 347495002957 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 347495002958 nucleophilic elbow; other site 347495002959 catalytic triad; other site 347495002960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495002961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495002962 Uncharacterized conserved protein [Function unknown]; Region: COG3402 347495002963 Predicted membrane protein [Function unknown]; Region: COG3428 347495002964 Bacterial PH domain; Region: DUF304; pfam03703 347495002965 Bacterial PH domain; Region: DUF304; cl01348 347495002966 Bacterial PH domain; Region: DUF304; pfam03703 347495002967 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 347495002968 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 347495002969 Uncharacterized conserved protein [Function unknown]; Region: COG3402 347495002970 Predicted membrane protein [Function unknown]; Region: COG3428 347495002971 Bacterial PH domain; Region: DUF304; pfam03703 347495002972 Bacterial PH domain; Region: DUF304; pfam03703 347495002973 Bacterial PH domain; Region: DUF304; pfam03703 347495002974 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 347495002975 Transglycosylase; Region: Transgly; pfam00912 347495002976 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 347495002977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495002978 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 347495002979 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 347495002980 substrate binding site [chemical binding]; other site 347495002981 active site 347495002982 ferrochelatase; Provisional; Region: PRK12435 347495002983 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 347495002984 C-terminal domain interface [polypeptide binding]; other site 347495002985 active site 347495002986 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 347495002987 active site 347495002988 N-terminal domain interface [polypeptide binding]; other site 347495002989 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 347495002990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495002991 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495002992 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 347495002993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 347495002994 Fn3 associated; Region: Fn3_assoc; pfam13287 347495002995 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 347495002996 generic binding surface II; other site 347495002997 generic binding surface I; other site 347495002998 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 347495002999 putative active site [active] 347495003000 putative catalytic site [active] 347495003001 putative Mg binding site IVb [ion binding]; other site 347495003002 putative phosphate binding site [ion binding]; other site 347495003003 putative DNA binding site [nucleotide binding]; other site 347495003004 putative Mg binding site IVa [ion binding]; other site 347495003005 Penicillinase repressor; Region: Pencillinase_R; pfam03965 347495003006 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 347495003007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495003008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495003009 Predicted membrane protein [Function unknown]; Region: COG1511 347495003010 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 347495003011 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 347495003012 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 347495003013 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 347495003014 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 347495003015 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 347495003016 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495003017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495003018 Coenzyme A binding pocket [chemical binding]; other site 347495003019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495003020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495003021 DNA binding site [nucleotide binding] 347495003022 domain linker motif; other site 347495003023 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 347495003024 putative dimerization interface [polypeptide binding]; other site 347495003025 putative ligand binding site [chemical binding]; other site 347495003026 YhfH-like protein; Region: YhfH; pfam14149 347495003027 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 347495003028 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 347495003029 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 347495003030 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 347495003031 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 347495003032 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 347495003033 acyl-activating enzyme (AAE) consensus motif; other site 347495003034 putative AMP binding site [chemical binding]; other site 347495003035 putative active site [active] 347495003036 putative CoA binding site [chemical binding]; other site 347495003037 rod-segment of the talin C-terminal domain; Region: talin-RS; cd12150 347495003038 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495003039 heme-binding site [chemical binding]; other site 347495003040 S-layer homology domain; Region: SLH; pfam00395 347495003041 S-layer homology domain; Region: SLH; pfam00395 347495003042 S-layer homology domain; Region: SLH; pfam00395 347495003043 RHS protein; Region: RHS; pfam03527 347495003044 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 347495003045 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495003046 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 347495003047 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495003048 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495003049 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 347495003050 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 347495003051 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495003052 putative active site [active] 347495003053 putative metal binding site [ion binding]; other site 347495003054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495003055 Zn2+ binding site [ion binding]; other site 347495003056 Mg2+ binding site [ion binding]; other site 347495003057 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 347495003058 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 347495003059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495003060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495003061 DNA binding residues [nucleotide binding] 347495003062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495003063 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 347495003064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495003065 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 347495003066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495003067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495003068 dimer interface [polypeptide binding]; other site 347495003069 phosphorylation site [posttranslational modification] 347495003070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495003071 ATP binding site [chemical binding]; other site 347495003072 Mg2+ binding site [ion binding]; other site 347495003073 G-X-G motif; other site 347495003074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495003075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495003076 active site 347495003077 phosphorylation site [posttranslational modification] 347495003078 intermolecular recognition site; other site 347495003079 dimerization interface [polypeptide binding]; other site 347495003080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495003081 DNA binding site [nucleotide binding] 347495003082 CAAX protease self-immunity; Region: Abi; pfam02517 347495003083 Peptidase family M48; Region: Peptidase_M48; pfam01435 347495003084 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 347495003085 EamA-like transporter family; Region: EamA; pfam00892 347495003086 EamA-like transporter family; Region: EamA; pfam00892 347495003087 S-layer homology domain; Region: SLH; pfam00395 347495003088 S-layer homology domain; Region: SLH; pfam00395 347495003089 S-layer homology domain; Region: SLH; pfam00395 347495003090 S-layer homology domain; Region: SLH; pfam00395 347495003091 S-layer homology domain; Region: SLH; pfam00395 347495003092 S-layer homology domain; Region: SLH; pfam00395 347495003093 S-layer homology domain; Region: SLH; pfam00395 347495003094 S-layer homology domain; Region: SLH; pfam00395 347495003095 S-layer homology domain; Region: SLH; pfam00395 347495003096 malate synthase A; Region: malate_syn_A; TIGR01344 347495003097 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 347495003098 active site 347495003099 isocitrate lyase; Provisional; Region: PRK15063 347495003100 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 347495003101 tetramer interface [polypeptide binding]; other site 347495003102 active site 347495003103 Mg2+/Mn2+ binding site [ion binding]; other site 347495003104 Phosphotransferase enzyme family; Region: APH; pfam01636 347495003105 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 347495003106 active site 347495003107 substrate binding site [chemical binding]; other site 347495003108 ATP binding site [chemical binding]; other site 347495003109 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 347495003110 DNA-binding site [nucleotide binding]; DNA binding site 347495003111 RNA-binding motif; other site 347495003112 ComK protein; Region: ComK; pfam06338 347495003113 Uncharacterized conserved protein [Function unknown]; Region: COG0398 347495003114 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495003115 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 347495003116 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495003117 Catalytic site [active] 347495003118 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495003119 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 347495003120 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 347495003121 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 347495003122 Part of AAA domain; Region: AAA_19; pfam13245 347495003123 Family description; Region: UvrD_C_2; pfam13538 347495003124 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 347495003125 hypothetical protein; Provisional; Region: PRK07758 347495003126 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 347495003127 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 347495003128 Spore germination protein GerPC; Region: GerPC; pfam10737 347495003129 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 347495003130 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 347495003131 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 347495003132 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 347495003133 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 347495003134 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 347495003135 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495003136 inhibitor-cofactor binding pocket; inhibition site 347495003137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495003138 catalytic residue [active] 347495003139 hypothetical protein; Provisional; Region: PRK13673 347495003140 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 347495003141 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 347495003142 active site 347495003143 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 347495003144 dimer interface [polypeptide binding]; other site 347495003145 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 347495003146 Ligand Binding Site [chemical binding]; other site 347495003147 Molecular Tunnel; other site 347495003148 ferrochelatase; Provisional; Region: PRK12435 347495003149 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 347495003150 C-terminal domain interface [polypeptide binding]; other site 347495003151 active site 347495003152 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 347495003153 active site 347495003154 N-terminal domain interface [polypeptide binding]; other site 347495003155 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 347495003156 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 347495003157 tetramer interface [polypeptide binding]; other site 347495003158 heme binding pocket [chemical binding]; other site 347495003159 potential frameshift: common BLAST hit: gi|225863110|ref|YP_002748488.1| ammonium transporter 347495003160 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 347495003161 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 347495003162 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 347495003163 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 347495003164 active site 347495003165 catalytic site [active] 347495003166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495003167 non-specific DNA binding site [nucleotide binding]; other site 347495003168 salt bridge; other site 347495003169 sequence-specific DNA binding site [nucleotide binding]; other site 347495003170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495003171 binding surface 347495003172 TPR motif; other site 347495003173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495003174 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 347495003175 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 347495003176 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 347495003177 S1 domain; Region: S1_2; pfam13509 347495003178 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 347495003179 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 347495003180 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495003181 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495003182 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495003183 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495003184 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 347495003185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495003186 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495003187 active site 347495003188 motif I; other site 347495003189 motif II; other site 347495003190 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 347495003191 YjzC-like protein; Region: YjzC; pfam14168 347495003192 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 347495003193 Clp amino terminal domain; Region: Clp_N; pfam02861 347495003194 Clp amino terminal domain; Region: Clp_N; pfam02861 347495003195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495003196 Walker A motif; other site 347495003197 ATP binding site [chemical binding]; other site 347495003198 Walker B motif; other site 347495003199 arginine finger; other site 347495003200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495003201 Walker A motif; other site 347495003202 ATP binding site [chemical binding]; other site 347495003203 Walker B motif; other site 347495003204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 347495003205 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 347495003206 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 347495003207 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 347495003208 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 347495003209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495003210 NAD(P) binding site [chemical binding]; other site 347495003211 active site 347495003212 ComZ; Region: ComZ; pfam10815 347495003213 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 347495003214 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 347495003215 dimer interface [polypeptide binding]; other site 347495003216 active site 347495003217 CoA binding pocket [chemical binding]; other site 347495003218 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 347495003219 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 347495003220 dimer interface [polypeptide binding]; other site 347495003221 active site 347495003222 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 347495003223 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 347495003224 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 347495003225 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 347495003226 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 347495003227 active site 347495003228 HIGH motif; other site 347495003229 dimer interface [polypeptide binding]; other site 347495003230 KMSKS motif; other site 347495003231 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 347495003232 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495003233 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495003234 peptide binding site [polypeptide binding]; other site 347495003235 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495003236 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495003237 dimer interface [polypeptide binding]; other site 347495003238 conserved gate region; other site 347495003239 putative PBP binding loops; other site 347495003240 ABC-ATPase subunit interface; other site 347495003241 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 347495003242 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 347495003243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495003244 dimer interface [polypeptide binding]; other site 347495003245 conserved gate region; other site 347495003246 putative PBP binding loops; other site 347495003247 ABC-ATPase subunit interface; other site 347495003248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 347495003249 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495003250 Walker A/P-loop; other site 347495003251 ATP binding site [chemical binding]; other site 347495003252 Q-loop/lid; other site 347495003253 ABC transporter signature motif; other site 347495003254 Walker B; other site 347495003255 D-loop; other site 347495003256 H-loop/switch region; other site 347495003257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 347495003258 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 347495003259 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495003260 Walker A/P-loop; other site 347495003261 ATP binding site [chemical binding]; other site 347495003262 Q-loop/lid; other site 347495003263 ABC transporter signature motif; other site 347495003264 Walker B; other site 347495003265 D-loop; other site 347495003266 H-loop/switch region; other site 347495003267 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 347495003268 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 347495003269 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 347495003270 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495003271 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495003272 peptide binding site [polypeptide binding]; other site 347495003273 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 347495003274 ArsC family; Region: ArsC; pfam03960 347495003275 putative catalytic residues [active] 347495003276 thiol/disulfide switch; other site 347495003277 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 347495003278 adaptor protein; Provisional; Region: PRK02315 347495003279 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 347495003280 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 347495003281 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 347495003282 putative active site [active] 347495003283 catalytic site [active] 347495003284 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 347495003285 putative active site [active] 347495003286 catalytic site [active] 347495003287 Competence protein CoiA-like family; Region: CoiA; cl11541 347495003288 oligoendopeptidase F; Region: pepF; TIGR00181 347495003289 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 347495003290 active site 347495003291 Zn binding site [ion binding]; other site 347495003292 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 347495003293 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 347495003294 catalytic residues [active] 347495003295 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 347495003296 apolar tunnel; other site 347495003297 heme binding site [chemical binding]; other site 347495003298 dimerization interface [polypeptide binding]; other site 347495003299 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 347495003300 putative active site [active] 347495003301 putative metal binding residues [ion binding]; other site 347495003302 signature motif; other site 347495003303 putative triphosphate binding site [ion binding]; other site 347495003304 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 347495003305 synthetase active site [active] 347495003306 NTP binding site [chemical binding]; other site 347495003307 metal binding site [ion binding]; metal-binding site 347495003308 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 347495003309 ATP-NAD kinase; Region: NAD_kinase; pfam01513 347495003310 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 347495003311 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 347495003312 active site 347495003313 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 347495003314 trimer interface [polypeptide binding]; other site 347495003315 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 347495003316 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 347495003317 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 347495003318 active site 347495003319 metal binding site [ion binding]; metal-binding site 347495003320 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 347495003321 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 347495003322 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 347495003323 active site 347495003324 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495003325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495003326 S-adenosylmethionine binding site [chemical binding]; other site 347495003327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 347495003328 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 347495003329 putative metal binding site; other site 347495003330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495003331 binding surface 347495003332 TPR motif; other site 347495003333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495003334 binding surface 347495003335 TPR motif; other site 347495003336 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495003337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495003338 S-adenosylmethionine binding site [chemical binding]; other site 347495003339 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 347495003340 catalytic residues [active] 347495003341 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 347495003342 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 347495003343 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495003344 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 347495003345 active site 347495003346 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 347495003347 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 347495003348 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 347495003349 NAD binding site [chemical binding]; other site 347495003350 substrate binding site [chemical binding]; other site 347495003351 homodimer interface [polypeptide binding]; other site 347495003352 active site 347495003353 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 347495003354 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 347495003355 NADP binding site [chemical binding]; other site 347495003356 active site 347495003357 putative substrate binding site [chemical binding]; other site 347495003358 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 347495003359 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 347495003360 NAD binding site [chemical binding]; other site 347495003361 homotetramer interface [polypeptide binding]; other site 347495003362 homodimer interface [polypeptide binding]; other site 347495003363 substrate binding site [chemical binding]; other site 347495003364 active site 347495003365 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 347495003366 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 347495003367 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 347495003368 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 347495003369 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 347495003370 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 347495003371 Part of AAA domain; Region: AAA_19; pfam13245 347495003372 Family description; Region: UvrD_C_2; pfam13538 347495003373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 347495003374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495003375 Coenzyme A binding pocket [chemical binding]; other site 347495003376 hypothetical protein; Provisional; Region: PRK13679 347495003377 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 347495003378 Putative esterase; Region: Esterase; pfam00756 347495003379 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 347495003380 EamA-like transporter family; Region: EamA; pfam00892 347495003381 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 347495003382 EamA-like transporter family; Region: EamA; pfam00892 347495003383 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 347495003384 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 347495003385 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 347495003386 Na binding site [ion binding]; other site 347495003387 anthranilate synthase component I; Provisional; Region: PRK13570 347495003388 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 347495003389 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 347495003390 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 347495003391 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 347495003392 glutamine binding [chemical binding]; other site 347495003393 catalytic triad [active] 347495003394 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 347495003395 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 347495003396 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 347495003397 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 347495003398 active site 347495003399 ribulose/triose binding site [chemical binding]; other site 347495003400 phosphate binding site [ion binding]; other site 347495003401 substrate (anthranilate) binding pocket [chemical binding]; other site 347495003402 product (indole) binding pocket [chemical binding]; other site 347495003403 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 347495003404 active site 347495003405 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 347495003406 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 347495003407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495003408 catalytic residue [active] 347495003409 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 347495003410 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 347495003411 substrate binding site [chemical binding]; other site 347495003412 active site 347495003413 catalytic residues [active] 347495003414 heterodimer interface [polypeptide binding]; other site 347495003415 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 347495003416 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 347495003417 L-lactate permease; Region: Lactate_perm; cl00701 347495003418 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 347495003419 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 347495003420 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495003421 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 347495003422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495003423 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 347495003424 Predicted acetyltransferase [General function prediction only]; Region: COG5628 347495003425 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 347495003426 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 347495003427 NADPH bind site [chemical binding]; other site 347495003428 putative FMN binding site [chemical binding]; other site 347495003429 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 347495003430 putative FMN binding site [chemical binding]; other site 347495003431 NADPH bind site [chemical binding]; other site 347495003432 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 347495003433 YcaO-like family; Region: YcaO; pfam02624 347495003434 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 347495003435 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 347495003436 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 347495003437 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 347495003438 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 347495003439 E3 interaction surface; other site 347495003440 lipoyl attachment site [posttranslational modification]; other site 347495003441 e3 binding domain; Region: E3_binding; pfam02817 347495003442 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 347495003443 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 347495003444 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 347495003445 TPP-binding site [chemical binding]; other site 347495003446 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 347495003447 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495003448 salt bridge; other site 347495003449 non-specific DNA binding site [nucleotide binding]; other site 347495003450 sequence-specific DNA binding site [nucleotide binding]; other site 347495003451 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 347495003452 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495003453 Transcriptional regulator PadR-like family; Region: PadR; cl17335 347495003454 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495003455 Methyltransferase domain; Region: Methyltransf_25; pfam13649 347495003456 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 347495003457 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 347495003458 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495003459 catalytic residue [active] 347495003460 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 347495003461 classical (c) SDRs; Region: SDR_c; cd05233 347495003462 NAD(P) binding site [chemical binding]; other site 347495003463 active site 347495003464 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 347495003465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495003466 Walker A/P-loop; other site 347495003467 ATP binding site [chemical binding]; other site 347495003468 Q-loop/lid; other site 347495003469 ABC transporter signature motif; other site 347495003470 Walker B; other site 347495003471 D-loop; other site 347495003472 H-loop/switch region; other site 347495003473 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 347495003474 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 347495003475 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495003476 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 347495003477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495003478 S-adenosylmethionine binding site [chemical binding]; other site 347495003479 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 347495003480 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495003481 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 347495003482 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 347495003483 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495003484 Catalytic site [active] 347495003485 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 347495003486 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 347495003487 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 347495003488 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495003489 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495003490 non-specific DNA binding site [nucleotide binding]; other site 347495003491 salt bridge; other site 347495003492 sequence-specific DNA binding site [nucleotide binding]; other site 347495003493 Anti-repressor SinI; Region: SinI; pfam08671 347495003494 Anti-repressor SinI; Region: SinI; pfam08671 347495003495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 347495003496 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 347495003497 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 347495003498 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 347495003499 NAD(P) binding site [chemical binding]; other site 347495003500 catalytic residues [active] 347495003501 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 347495003502 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 347495003503 Walker A/P-loop; other site 347495003504 ATP binding site [chemical binding]; other site 347495003505 Q-loop/lid; other site 347495003506 ABC transporter signature motif; other site 347495003507 Walker B; other site 347495003508 D-loop; other site 347495003509 H-loop/switch region; other site 347495003510 TOBE domain; Region: TOBE_2; pfam08402 347495003511 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 347495003512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495003513 dimer interface [polypeptide binding]; other site 347495003514 conserved gate region; other site 347495003515 putative PBP binding loops; other site 347495003516 ABC-ATPase subunit interface; other site 347495003517 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 347495003518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495003519 dimer interface [polypeptide binding]; other site 347495003520 conserved gate region; other site 347495003521 putative PBP binding loops; other site 347495003522 ABC-ATPase subunit interface; other site 347495003523 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 347495003524 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 347495003525 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 347495003526 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 347495003527 active site 347495003528 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 347495003529 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 347495003530 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 347495003531 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 347495003532 active site 347495003533 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 347495003534 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 347495003535 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 347495003536 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 347495003537 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 347495003538 Cysteine-rich domain; Region: CCG; pfam02754 347495003539 Cysteine-rich domain; Region: CCG; pfam02754 347495003540 FAD binding domain; Region: FAD_binding_4; pfam01565 347495003541 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 347495003542 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 347495003543 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 347495003544 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 347495003545 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 347495003546 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 347495003547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495003548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495003549 active site 347495003550 phosphorylation site [posttranslational modification] 347495003551 intermolecular recognition site; other site 347495003552 dimerization interface [polypeptide binding]; other site 347495003553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495003554 DNA binding site [nucleotide binding] 347495003555 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 347495003556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495003557 dimerization interface [polypeptide binding]; other site 347495003558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495003559 dimer interface [polypeptide binding]; other site 347495003560 phosphorylation site [posttranslational modification] 347495003561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495003562 ATP binding site [chemical binding]; other site 347495003563 Mg2+ binding site [ion binding]; other site 347495003564 G-X-G motif; other site 347495003565 Transcriptional regulators [Transcription]; Region: FadR; COG2186 347495003566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495003567 DNA-binding site [nucleotide binding]; DNA binding site 347495003568 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 347495003569 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 347495003570 Cysteine-rich domain; Region: CCG; pfam02754 347495003571 Cysteine-rich domain; Region: CCG; pfam02754 347495003572 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 347495003573 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 347495003574 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 347495003575 Uncharacterized conserved protein [Function unknown]; Region: COG1556 347495003576 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 347495003577 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 347495003578 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 347495003579 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 347495003580 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 347495003581 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 347495003582 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 347495003583 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495003584 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 347495003585 dimer interaction site [polypeptide binding]; other site 347495003586 substrate-binding tunnel; other site 347495003587 active site 347495003588 catalytic site [active] 347495003589 substrate binding site [chemical binding]; other site 347495003590 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 347495003591 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 347495003592 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495003593 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 347495003594 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 347495003595 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 347495003596 NAD(P) binding site [chemical binding]; other site 347495003597 homotetramer interface [polypeptide binding]; other site 347495003598 homodimer interface [polypeptide binding]; other site 347495003599 active site 347495003600 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 347495003601 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 347495003602 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 347495003603 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 347495003604 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 347495003605 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 347495003606 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 347495003607 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 347495003608 putative 2-aminoethylphosphonate ABC transporter, periplasmic 2-aminoethylphosphonate-binding protein; Region: phnS2; TIGR03261 347495003609 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 347495003610 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 347495003611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495003612 Walker A/P-loop; other site 347495003613 ATP binding site [chemical binding]; other site 347495003614 Q-loop/lid; other site 347495003615 ABC transporter signature motif; other site 347495003616 Walker B; other site 347495003617 D-loop; other site 347495003618 H-loop/switch region; other site 347495003619 TOBE domain; Region: TOBE_2; pfam08402 347495003620 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 347495003621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495003622 dimer interface [polypeptide binding]; other site 347495003623 conserved gate region; other site 347495003624 putative PBP binding loops; other site 347495003625 ABC-ATPase subunit interface; other site 347495003626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495003627 dimer interface [polypeptide binding]; other site 347495003628 conserved gate region; other site 347495003629 putative PBP binding loops; other site 347495003630 ABC-ATPase subunit interface; other site 347495003631 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 347495003632 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495003633 motif II; other site 347495003634 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 347495003635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495003636 catalytic residue [active] 347495003637 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 347495003638 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 347495003639 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 347495003640 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 347495003641 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495003642 heme-binding site [chemical binding]; other site 347495003643 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495003644 Leucine rich repeat; Region: LRR_8; pfam13855 347495003645 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 347495003646 Leucine rich repeat; Region: LRR_8; pfam13855 347495003647 Leucine-rich repeats; other site 347495003648 Substrate binding site [chemical binding]; other site 347495003649 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495003650 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495003651 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 347495003652 Leucine rich repeat; Region: LRR_8; pfam13855 347495003653 S-layer homology domain; Region: SLH; pfam00395 347495003654 S-layer homology domain; Region: SLH; pfam00395 347495003655 S-layer homology domain; Region: SLH; pfam00395 347495003656 hypothetical protein; Validated; Region: PRK06755 347495003657 intersubunit interface [polypeptide binding]; other site 347495003658 active site 347495003659 Zn2+ binding site [ion binding]; other site 347495003660 FOG: CBS domain [General function prediction only]; Region: COG0517 347495003661 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 347495003662 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 347495003663 NodB motif; other site 347495003664 putative active site [active] 347495003665 putative catalytic site [active] 347495003666 Zn binding site [ion binding]; other site 347495003667 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 347495003668 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 347495003669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495003670 dimer interface [polypeptide binding]; other site 347495003671 phosphorylation site [posttranslational modification] 347495003672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495003673 ATP binding site [chemical binding]; other site 347495003674 Mg2+ binding site [ion binding]; other site 347495003675 G-X-G motif; other site 347495003676 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495003677 MarR family; Region: MarR; pfam01047 347495003678 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 347495003679 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 347495003680 active site 347495003681 Zn binding site [ion binding]; other site 347495003682 DinB superfamily; Region: DinB_2; pfam12867 347495003683 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 347495003684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495003685 dimer interface [polypeptide binding]; other site 347495003686 phosphorylation site [posttranslational modification] 347495003687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495003688 ATP binding site [chemical binding]; other site 347495003689 Mg2+ binding site [ion binding]; other site 347495003690 G-X-G motif; other site 347495003691 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 347495003692 Ligand Binding Site [chemical binding]; other site 347495003693 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 347495003694 active site 347495003695 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 347495003696 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 347495003697 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 347495003698 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 347495003699 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 347495003700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495003701 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 347495003702 Coenzyme A binding pocket [chemical binding]; other site 347495003703 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 347495003704 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 347495003705 Class I ribonucleotide reductase; Region: RNR_I; cd01679 347495003706 active site 347495003707 dimer interface [polypeptide binding]; other site 347495003708 catalytic residues [active] 347495003709 effector binding site; other site 347495003710 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 347495003711 active site 347495003712 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 347495003713 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 347495003714 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 347495003715 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 347495003716 dimer interface [polypeptide binding]; other site 347495003717 putative radical transfer pathway; other site 347495003718 diiron center [ion binding]; other site 347495003719 tyrosyl radical; other site 347495003720 Predicted transcriptional regulators [Transcription]; Region: COG1725 347495003721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495003722 DNA-binding site [nucleotide binding]; DNA binding site 347495003723 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 347495003724 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495003725 Walker A/P-loop; other site 347495003726 ATP binding site [chemical binding]; other site 347495003727 Q-loop/lid; other site 347495003728 ABC transporter signature motif; other site 347495003729 Walker B; other site 347495003730 D-loop; other site 347495003731 H-loop/switch region; other site 347495003732 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495003733 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495003734 Walker A/P-loop; other site 347495003735 ATP binding site [chemical binding]; other site 347495003736 Q-loop/lid; other site 347495003737 ABC transporter signature motif; other site 347495003738 Walker B; other site 347495003739 D-loop; other site 347495003740 H-loop/switch region; other site 347495003741 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495003742 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 347495003743 CAAX protease self-immunity; Region: Abi; pfam02517 347495003744 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 347495003745 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 347495003746 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 347495003747 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495003748 putative DNA binding site [nucleotide binding]; other site 347495003749 putative Zn2+ binding site [ion binding]; other site 347495003750 AsnC family; Region: AsnC_trans_reg; pfam01037 347495003751 Uncharacterized conserved protein [Function unknown]; Region: COG2128 347495003752 Isochorismatase family; Region: Isochorismatase; pfam00857 347495003753 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 347495003754 catalytic triad [active] 347495003755 conserved cis-peptide bond; other site 347495003756 SseB protein; Region: SseB; cl06279 347495003757 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 347495003758 dimer interface [polypeptide binding]; other site 347495003759 catalytic triad [active] 347495003760 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 347495003761 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 347495003762 FMN binding site [chemical binding]; other site 347495003763 substrate binding site [chemical binding]; other site 347495003764 putative catalytic residue [active] 347495003765 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 347495003766 DltD N-terminal region; Region: DltD_N; pfam04915 347495003767 DltD central region; Region: DltD_M; pfam04918 347495003768 DltD C-terminal region; Region: DltD_C; pfam04914 347495003769 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 347495003770 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 347495003771 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 347495003772 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 347495003773 acyl-activating enzyme (AAE) consensus motif; other site 347495003774 AMP binding site [chemical binding]; other site 347495003775 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 347495003776 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 347495003777 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 347495003778 metal binding site [ion binding]; metal-binding site 347495003779 dimer interface [polypeptide binding]; other site 347495003780 flavodoxin; Provisional; Region: PRK06756 347495003781 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 347495003782 Phosphotransferase enzyme family; Region: APH; pfam01636 347495003783 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495003784 active site 347495003785 substrate binding site [chemical binding]; other site 347495003786 ATP binding site [chemical binding]; other site 347495003787 Wnt and FGF inhibitory regulator; Region: Shisa; pfam13908 347495003788 multidrug efflux protein; Reviewed; Region: PRK01766 347495003789 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 347495003790 cation binding site [ion binding]; other site 347495003791 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 347495003792 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 347495003793 Regulatory protein YrvL; Region: YrvL; pfam14184 347495003794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495003795 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 347495003796 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 347495003797 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 347495003798 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 347495003799 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 347495003800 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 347495003801 hypothetical protein; Provisional; Region: PRK03094 347495003802 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 347495003803 flavin-containing monooxygenase FMO GS-OX; Region: PLN02172 347495003804 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 347495003805 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 347495003806 homodimer interface [polypeptide binding]; other site 347495003807 substrate-cofactor binding pocket; other site 347495003808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495003809 catalytic residue [active] 347495003810 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 347495003811 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 347495003812 PYR/PP interface [polypeptide binding]; other site 347495003813 dimer interface [polypeptide binding]; other site 347495003814 TPP binding site [chemical binding]; other site 347495003815 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 347495003816 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 347495003817 TPP-binding site [chemical binding]; other site 347495003818 dimer interface [polypeptide binding]; other site 347495003819 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 347495003820 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 347495003821 putative valine binding site [chemical binding]; other site 347495003822 dimer interface [polypeptide binding]; other site 347495003823 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 347495003824 ketol-acid reductoisomerase; Provisional; Region: PRK05479 347495003825 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 347495003826 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 347495003827 2-isopropylmalate synthase; Validated; Region: PRK00915 347495003828 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 347495003829 active site 347495003830 catalytic residues [active] 347495003831 metal binding site [ion binding]; metal-binding site 347495003832 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 347495003833 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 347495003834 tartrate dehydrogenase; Region: TTC; TIGR02089 347495003835 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 347495003836 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 347495003837 substrate binding site [chemical binding]; other site 347495003838 ligand binding site [chemical binding]; other site 347495003839 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 347495003840 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 347495003841 substrate binding site [chemical binding]; other site 347495003842 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 347495003843 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 347495003844 dimer interface [polypeptide binding]; other site 347495003845 motif 1; other site 347495003846 active site 347495003847 motif 2; other site 347495003848 motif 3; other site 347495003849 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 347495003850 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 347495003851 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 347495003852 histidinol dehydrogenase; Region: hisD; TIGR00069 347495003853 NAD binding site [chemical binding]; other site 347495003854 dimerization interface [polypeptide binding]; other site 347495003855 product binding site; other site 347495003856 substrate binding site [chemical binding]; other site 347495003857 zinc binding site [ion binding]; other site 347495003858 catalytic residues [active] 347495003859 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 347495003860 putative active site pocket [active] 347495003861 4-fold oligomerization interface [polypeptide binding]; other site 347495003862 metal binding residues [ion binding]; metal-binding site 347495003863 3-fold/trimer interface [polypeptide binding]; other site 347495003864 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 347495003865 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 347495003866 putative active site [active] 347495003867 oxyanion strand; other site 347495003868 catalytic triad [active] 347495003869 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 347495003870 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 347495003871 catalytic residues [active] 347495003872 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 347495003873 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 347495003874 substrate binding site [chemical binding]; other site 347495003875 glutamase interaction surface [polypeptide binding]; other site 347495003876 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 347495003877 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 347495003878 metal binding site [ion binding]; metal-binding site 347495003879 histidinol-phosphatase; Validated; Region: PRK06740 347495003880 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 347495003881 dimer interface [polypeptide binding]; other site 347495003882 active site 347495003883 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 347495003884 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 347495003885 putative ligand binding site [chemical binding]; other site 347495003886 putative NAD binding site [chemical binding]; other site 347495003887 catalytic site [active] 347495003888 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 347495003889 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 347495003890 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 347495003891 Sulfatase; Region: Sulfatase; pfam00884 347495003892 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 347495003893 diaminopimelate decarboxylase; Region: lysA; TIGR01048 347495003894 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 347495003895 active site 347495003896 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 347495003897 substrate binding site [chemical binding]; other site 347495003898 catalytic residues [active] 347495003899 dimer interface [polypeptide binding]; other site 347495003900 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 347495003901 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 347495003902 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 347495003903 Active Sites [active] 347495003904 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 347495003905 ATP-sulfurylase; Region: ATPS; cd00517 347495003906 active site 347495003907 HXXH motif; other site 347495003908 flexible loop; other site 347495003909 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 347495003910 ligand-binding site [chemical binding]; other site 347495003911 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 347495003912 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 347495003913 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 347495003914 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 347495003915 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 347495003916 diphthine synthase; Region: dph5; TIGR00522 347495003917 active site 347495003918 SAM binding site [chemical binding]; other site 347495003919 homodimer interface [polypeptide binding]; other site 347495003920 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 347495003921 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 347495003922 putative active site [active] 347495003923 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 347495003924 putative active site [active] 347495003925 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 347495003926 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 347495003927 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 347495003928 Na2 binding site [ion binding]; other site 347495003929 putative substrate binding site 1 [chemical binding]; other site 347495003930 Na binding site 1 [ion binding]; other site 347495003931 putative substrate binding site 2 [chemical binding]; other site 347495003932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 347495003933 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495003934 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495003935 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 347495003936 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 347495003937 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 347495003938 Protein of unknown function (DUF402); Region: DUF402; cl00979 347495003939 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 347495003940 Vpu protein; Region: Vpu; pfam00558 347495003941 PspA/IM30 family; Region: PspA_IM30; pfam04012 347495003942 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 347495003943 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495003944 Histidine kinase; Region: HisKA_3; pfam07730 347495003945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495003946 ATP binding site [chemical binding]; other site 347495003947 Mg2+ binding site [ion binding]; other site 347495003948 G-X-G motif; other site 347495003949 potential frameshift: common BLAST hit: gi|301053077|ref|YP_003791288.1| response regulator 347495003950 Response regulator receiver domain; Region: Response_reg; pfam00072 347495003951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495003952 active site 347495003953 phosphorylation site [posttranslational modification] 347495003954 intermolecular recognition site; other site 347495003955 dimerization interface [polypeptide binding]; other site 347495003956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495003957 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495003958 DNA binding residues [nucleotide binding] 347495003959 dimerization interface [polypeptide binding]; other site 347495003960 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 347495003961 E3 interaction surface; other site 347495003962 lipoyl attachment site [posttranslational modification]; other site 347495003963 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 347495003964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495003965 S-adenosylmethionine binding site [chemical binding]; other site 347495003966 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 347495003967 Peptidase family M50; Region: Peptidase_M50; pfam02163 347495003968 active site 347495003969 putative substrate binding region [chemical binding]; other site 347495003970 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 347495003971 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 347495003972 heme-binding site [chemical binding]; other site 347495003973 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 347495003974 FAD binding pocket [chemical binding]; other site 347495003975 FAD binding motif [chemical binding]; other site 347495003976 phosphate binding motif [ion binding]; other site 347495003977 beta-alpha-beta structure motif; other site 347495003978 NAD binding pocket [chemical binding]; other site 347495003979 Heme binding pocket [chemical binding]; other site 347495003980 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 347495003981 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 347495003982 ligand binding site [chemical binding]; other site 347495003983 flexible hinge region; other site 347495003984 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 347495003985 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495003986 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 347495003987 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 347495003988 Transglycosylase; Region: Transgly; pfam00912 347495003989 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 347495003990 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495003991 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 347495003992 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495003993 putative active site [active] 347495003994 heme pocket [chemical binding]; other site 347495003995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495003996 dimer interface [polypeptide binding]; other site 347495003997 phosphorylation site [posttranslational modification] 347495003998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495003999 ATP binding site [chemical binding]; other site 347495004000 Mg2+ binding site [ion binding]; other site 347495004001 G-X-G motif; other site 347495004002 Protein of unknown function DUF72; Region: DUF72; pfam01904 347495004003 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 347495004004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 347495004005 active site 347495004006 DNA binding site [nucleotide binding] 347495004007 Int/Topo IB signature motif; other site 347495004008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495004009 dimerization interface [polypeptide binding]; other site 347495004010 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495004011 dimer interface [polypeptide binding]; other site 347495004012 phosphorylation site [posttranslational modification] 347495004013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495004014 ATP binding site [chemical binding]; other site 347495004015 Mg2+ binding site [ion binding]; other site 347495004016 G-X-G motif; other site 347495004017 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 347495004018 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 347495004019 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 347495004020 Predicted integral membrane protein [Function unknown]; Region: COG0392 347495004021 Uncharacterized conserved protein [Function unknown]; Region: COG2898 347495004022 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 347495004023 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 347495004024 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 347495004025 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 347495004026 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 347495004027 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495004028 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 347495004029 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 347495004030 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 347495004031 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 347495004032 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495004033 RNA binding surface [nucleotide binding]; other site 347495004034 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 347495004035 active site 347495004036 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 347495004037 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 347495004038 catalytic residues [active] 347495004039 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 347495004040 ResB-like family; Region: ResB; pfam05140 347495004041 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 347495004042 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 347495004043 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495004044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495004045 active site 347495004046 phosphorylation site [posttranslational modification] 347495004047 intermolecular recognition site; other site 347495004048 dimerization interface [polypeptide binding]; other site 347495004049 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495004050 DNA binding site [nucleotide binding] 347495004051 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 347495004052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495004053 dimerization interface [polypeptide binding]; other site 347495004054 PAS domain; Region: PAS; smart00091 347495004055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495004056 dimer interface [polypeptide binding]; other site 347495004057 phosphorylation site [posttranslational modification] 347495004058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495004059 ATP binding site [chemical binding]; other site 347495004060 Mg2+ binding site [ion binding]; other site 347495004061 G-X-G motif; other site 347495004062 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 347495004063 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495004064 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495004065 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495004066 Predicted membrane protein [Function unknown]; Region: COG3601 347495004067 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 347495004068 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 347495004069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 347495004070 DEAD-like helicases superfamily; Region: DEXDc; smart00487 347495004071 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495004072 ATP binding site [chemical binding]; other site 347495004073 putative Mg++ binding site [ion binding]; other site 347495004074 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495004075 nucleotide binding region [chemical binding]; other site 347495004076 ATP-binding site [chemical binding]; other site 347495004077 CAAX protease self-immunity; Region: Abi; pfam02517 347495004078 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495004079 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 347495004080 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495004081 putative active site [active] 347495004082 putative metal binding site [ion binding]; other site 347495004083 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495004084 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 347495004085 DNA binding residues [nucleotide binding] 347495004086 B12 binding domain; Region: B12-binding_2; pfam02607 347495004087 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 347495004088 potential frameshift: common BLAST hit: gi|227815663|ref|YP_002815672.1| adaptor protein 347495004089 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 347495004090 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 347495004091 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 347495004092 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 347495004093 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 347495004094 NAD(P) binding site [chemical binding]; other site 347495004095 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 347495004096 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 347495004097 amidase catalytic site [active] 347495004098 Zn binding residues [ion binding]; other site 347495004099 substrate binding site [chemical binding]; other site 347495004100 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 347495004101 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 347495004102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495004103 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 347495004104 active site 347495004105 homodimer interface [polypeptide binding]; other site 347495004106 homotetramer interface [polypeptide binding]; other site 347495004107 cytidylate kinase; Provisional; Region: cmk; PRK00023 347495004108 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 347495004109 CMP-binding site; other site 347495004110 The sites determining sugar specificity; other site 347495004111 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 347495004112 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 347495004113 RNA binding site [nucleotide binding]; other site 347495004114 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 347495004115 RNA binding site [nucleotide binding]; other site 347495004116 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 347495004117 RNA binding site [nucleotide binding]; other site 347495004118 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 347495004119 RNA binding site [nucleotide binding]; other site 347495004120 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 347495004121 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 347495004122 homotetramer interface [polypeptide binding]; other site 347495004123 FMN binding site [chemical binding]; other site 347495004124 homodimer contacts [polypeptide binding]; other site 347495004125 putative active site [active] 347495004126 putative substrate binding site [chemical binding]; other site 347495004127 YpzI-like protein; Region: YpzI; pfam14140 347495004128 YIEGIA protein; Region: YIEGIA; pfam14045 347495004129 GTP-binding protein Der; Reviewed; Region: PRK00093 347495004130 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 347495004131 G1 box; other site 347495004132 GTP/Mg2+ binding site [chemical binding]; other site 347495004133 Switch I region; other site 347495004134 G2 box; other site 347495004135 Switch II region; other site 347495004136 G3 box; other site 347495004137 G4 box; other site 347495004138 G5 box; other site 347495004139 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 347495004140 G1 box; other site 347495004141 GTP/Mg2+ binding site [chemical binding]; other site 347495004142 Switch I region; other site 347495004143 G2 box; other site 347495004144 G3 box; other site 347495004145 Switch II region; other site 347495004146 G4 box; other site 347495004147 G5 box; other site 347495004148 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 347495004149 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 347495004150 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 347495004151 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 347495004152 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 347495004153 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 347495004154 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 347495004155 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 347495004156 IHF dimer interface [polypeptide binding]; other site 347495004157 IHF - DNA interface [nucleotide binding]; other site 347495004158 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 347495004159 homodecamer interface [polypeptide binding]; other site 347495004160 GTP cyclohydrolase I; Provisional; Region: PLN03044 347495004161 active site 347495004162 putative catalytic site residues [active] 347495004163 zinc binding site [ion binding]; other site 347495004164 GTP-CH-I/GFRP interaction surface; other site 347495004165 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 347495004166 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 347495004167 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495004168 S-adenosylmethionine binding site [chemical binding]; other site 347495004169 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 347495004170 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 347495004171 substrate binding pocket [chemical binding]; other site 347495004172 chain length determination region; other site 347495004173 substrate-Mg2+ binding site; other site 347495004174 catalytic residues [active] 347495004175 aspartate-rich region 1; other site 347495004176 active site lid residues [active] 347495004177 aspartate-rich region 2; other site 347495004178 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 347495004179 active site 347495004180 multimer interface [polypeptide binding]; other site 347495004181 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 347495004182 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 347495004183 Tetramer interface [polypeptide binding]; other site 347495004184 active site 347495004185 FMN-binding site [chemical binding]; other site 347495004186 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 347495004187 active site 347495004188 dimer interface [polypeptide binding]; other site 347495004189 metal binding site [ion binding]; metal-binding site 347495004190 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 347495004191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495004192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495004193 homodimer interface [polypeptide binding]; other site 347495004194 catalytic residue [active] 347495004195 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495004196 TPR motif; other site 347495004197 binding surface 347495004198 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495004199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495004200 binding surface 347495004201 TPR motif; other site 347495004202 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 347495004203 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495004204 binding surface 347495004205 TPR motif; other site 347495004206 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495004207 TPR repeat; Region: TPR_11; pfam13414 347495004208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495004209 binding surface 347495004210 TPR motif; other site 347495004211 hypothetical protein; Provisional; Region: PRK03636 347495004212 UPF0302 domain; Region: UPF0302; pfam08864 347495004213 IDEAL domain; Region: IDEAL; pfam08858 347495004214 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 347495004215 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 347495004216 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 347495004217 iron-sulfur cluster [ion binding]; other site 347495004218 [2Fe-2S] cluster binding site [ion binding]; other site 347495004219 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 347495004220 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 347495004221 interchain domain interface [polypeptide binding]; other site 347495004222 intrachain domain interface; other site 347495004223 heme bH binding site [chemical binding]; other site 347495004224 Qi binding site; other site 347495004225 heme bL binding site [chemical binding]; other site 347495004226 Qo binding site; other site 347495004227 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 347495004228 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 347495004229 interchain domain interface [polypeptide binding]; other site 347495004230 intrachain domain interface; other site 347495004231 Qi binding site; other site 347495004232 Qo binding site; other site 347495004233 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 347495004234 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 347495004235 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 347495004236 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 347495004237 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 347495004238 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 347495004239 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 347495004240 active site 347495004241 Fe-S cluster binding site [ion binding]; other site 347495004242 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495004243 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495004244 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495004245 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495004246 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 347495004247 homodimer interface [polypeptide binding]; other site 347495004248 metal binding site [ion binding]; metal-binding site 347495004249 dihydrodipicolinate reductase; Provisional; Region: PRK00048 347495004250 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 347495004251 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 347495004252 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 347495004253 active site 347495004254 dimer interfaces [polypeptide binding]; other site 347495004255 catalytic residues [active] 347495004256 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 347495004257 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 347495004258 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 347495004259 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 347495004260 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 347495004261 active site 347495004262 NTP binding site [chemical binding]; other site 347495004263 metal binding triad [ion binding]; metal-binding site 347495004264 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 347495004265 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 347495004266 Biotin operon repressor [Transcription]; Region: BirA; COG1654 347495004267 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 347495004268 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 347495004269 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 347495004270 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 347495004271 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 347495004272 oligomerization interface [polypeptide binding]; other site 347495004273 active site 347495004274 metal binding site [ion binding]; metal-binding site 347495004275 pantoate--beta-alanine ligase; Region: panC; TIGR00018 347495004276 Pantoate-beta-alanine ligase; Region: PanC; cd00560 347495004277 active site 347495004278 ATP-binding site [chemical binding]; other site 347495004279 pantoate-binding site; other site 347495004280 HXXH motif; other site 347495004281 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 347495004282 tetramerization interface [polypeptide binding]; other site 347495004283 active site 347495004284 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 347495004285 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 347495004286 active site 347495004287 catalytic site [active] 347495004288 substrate binding site [chemical binding]; other site 347495004289 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 347495004290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495004291 nucleotide binding region [chemical binding]; other site 347495004292 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 347495004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 347495004294 aspartate aminotransferase; Provisional; Region: PRK05764 347495004295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495004296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495004297 homodimer interface [polypeptide binding]; other site 347495004298 catalytic residue [active] 347495004299 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 347495004300 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 347495004301 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 347495004302 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 347495004303 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 347495004304 minor groove reading motif; other site 347495004305 helix-hairpin-helix signature motif; other site 347495004306 substrate binding pocket [chemical binding]; other site 347495004307 active site 347495004308 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 347495004309 Transglycosylase; Region: Transgly; pfam00912 347495004310 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 347495004311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 347495004312 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 347495004313 Interdomain contacts; other site 347495004314 Cytokine receptor motif; other site 347495004315 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 347495004316 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 347495004317 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 347495004318 YppF-like protein; Region: YppF; pfam14178 347495004319 YppG-like protein; Region: YppG; pfam14179 347495004320 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 347495004321 hypothetical protein; Provisional; Region: PRK13660 347495004322 cell division protein GpsB; Provisional; Region: PRK14127 347495004323 DivIVA domain; Region: DivI1A_domain; TIGR03544 347495004324 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 347495004325 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 347495004326 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 347495004327 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 347495004328 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 347495004329 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 347495004330 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 347495004331 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 347495004332 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 347495004333 active site 347495004334 Zn binding site [ion binding]; other site 347495004335 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495004336 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 347495004337 Phosphotransferase enzyme family; Region: APH; pfam01636 347495004338 putative active site [active] 347495004339 putative substrate binding site [chemical binding]; other site 347495004340 ATP binding site [chemical binding]; other site 347495004341 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 347495004342 active site 347495004343 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495004344 active site 347495004345 xanthine permease; Region: pbuX; TIGR03173 347495004346 Predicted membrane protein [Function unknown]; Region: COG2311 347495004347 Protein of unknown function (DUF418); Region: DUF418; cl12135 347495004348 Protein of unknown function (DUF418); Region: DUF418; pfam04235 347495004349 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 347495004350 Dynamin family; Region: Dynamin_N; pfam00350 347495004351 G1 box; other site 347495004352 GTP/Mg2+ binding site [chemical binding]; other site 347495004353 G2 box; other site 347495004354 Switch I region; other site 347495004355 G3 box; other site 347495004356 Switch II region; other site 347495004357 G4 box; other site 347495004358 G5 box; other site 347495004359 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 347495004360 Dynamin family; Region: Dynamin_N; pfam00350 347495004361 G1 box; other site 347495004362 GTP/Mg2+ binding site [chemical binding]; other site 347495004363 G2 box; other site 347495004364 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 347495004365 G3 box; other site 347495004366 Switch II region; other site 347495004367 GTP/Mg2+ binding site [chemical binding]; other site 347495004368 G4 box; other site 347495004369 G5 box; other site 347495004370 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 347495004371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495004372 Coenzyme A binding pocket [chemical binding]; other site 347495004373 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 347495004374 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 347495004375 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 347495004376 active site residue [active] 347495004377 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 347495004378 active site residue [active] 347495004379 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 347495004380 Predicted membrane protein [Function unknown]; Region: COG3766 347495004381 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 347495004382 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 347495004383 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 347495004384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495004385 5'-3' exonuclease; Region: 53EXOc; smart00475 347495004386 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 347495004387 active site 347495004388 metal binding site 1 [ion binding]; metal-binding site 347495004389 putative 5' ssDNA interaction site; other site 347495004390 metal binding site 3; metal-binding site 347495004391 metal binding site 2 [ion binding]; metal-binding site 347495004392 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 347495004393 putative DNA binding site [nucleotide binding]; other site 347495004394 putative metal binding site [ion binding]; other site 347495004395 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 347495004396 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004397 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004398 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004399 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004400 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004401 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004402 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004403 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004404 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004405 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004406 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004407 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004408 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004409 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004410 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004411 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004412 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004413 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004414 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004415 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004416 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004417 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004418 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004419 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004420 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004421 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004422 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004423 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495004424 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495004425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495004426 Coenzyme A binding pocket [chemical binding]; other site 347495004427 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 347495004428 Isochorismatase family; Region: Isochorismatase; pfam00857 347495004429 catalytic triad [active] 347495004430 conserved cis-peptide bond; other site 347495004431 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495004432 EamA-like transporter family; Region: EamA; pfam00892 347495004433 EamA-like transporter family; Region: EamA; cl17759 347495004434 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 347495004435 RNA/DNA hybrid binding site [nucleotide binding]; other site 347495004436 active site 347495004437 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 347495004438 active site 347495004439 catalytic residues [active] 347495004440 QueT transporter; Region: QueT; pfam06177 347495004441 hypothetical protein; Validated; Region: PRK07708 347495004442 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 347495004443 RNA/DNA hybrid binding site [nucleotide binding]; other site 347495004444 active site 347495004445 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 347495004446 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 347495004447 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 347495004448 DNA-binding site [nucleotide binding]; DNA binding site 347495004449 RNA-binding motif; other site 347495004450 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 347495004451 LysE type translocator; Region: LysE; pfam01810 347495004452 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 347495004453 Protein of unknown function, DUF485; Region: DUF485; pfam04341 347495004454 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 347495004455 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 347495004456 Na binding site [ion binding]; other site 347495004457 aminotransferase; Validated; Region: PRK07678 347495004458 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495004459 inhibitor-cofactor binding pocket; inhibition site 347495004460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495004461 catalytic residue [active] 347495004462 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 347495004463 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 347495004464 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 347495004465 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 347495004466 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495004467 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 347495004468 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 347495004469 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 347495004470 DNA binding residues [nucleotide binding] 347495004471 drug binding residues [chemical binding]; other site 347495004472 dimer interface [polypeptide binding]; other site 347495004473 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 347495004474 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 347495004475 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 347495004476 Predicted membrane protein [Function unknown]; Region: COG2323 347495004477 Uncharacterized conserved protein [Function unknown]; Region: COG1434 347495004478 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 347495004479 putative active site [active] 347495004480 Tic20-like protein; Region: Tic20; pfam09685 347495004481 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 347495004482 dimer interface [polypeptide binding]; other site 347495004483 FMN binding site [chemical binding]; other site 347495004484 NADPH bind site [chemical binding]; other site 347495004485 DJ-1 family protein; Region: not_thiJ; TIGR01383 347495004486 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 347495004487 conserved cys residue [active] 347495004488 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495004489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495004490 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495004491 putative substrate translocation pore; other site 347495004492 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495004493 dimerization interface [polypeptide binding]; other site 347495004494 putative DNA binding site [nucleotide binding]; other site 347495004495 putative Zn2+ binding site [ion binding]; other site 347495004496 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495004497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495004498 putative substrate translocation pore; other site 347495004499 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495004500 active site 347495004501 metal binding site [ion binding]; metal-binding site 347495004502 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495004503 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 347495004504 bacterial Hfq-like; Region: Hfq; cd01716 347495004505 hexamer interface [polypeptide binding]; other site 347495004506 Sm1 motif; other site 347495004507 RNA binding site [nucleotide binding]; other site 347495004508 Sm2 motif; other site 347495004509 HD domain; Region: HD_3; pfam13023 347495004510 flagellar motor protein MotP; Reviewed; Region: PRK06743 347495004511 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 347495004512 flagellar motor protein MotS; Reviewed; Region: PRK06742 347495004513 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 347495004514 ligand binding site [chemical binding]; other site 347495004515 Response regulator receiver domain; Region: Response_reg; pfam00072 347495004516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495004517 active site 347495004518 phosphorylation site [posttranslational modification] 347495004519 intermolecular recognition site; other site 347495004520 dimerization interface [polypeptide binding]; other site 347495004521 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 347495004522 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 347495004523 putative binding surface; other site 347495004524 active site 347495004525 P2 response regulator binding domain; Region: P2; pfam07194 347495004526 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 347495004527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495004528 ATP binding site [chemical binding]; other site 347495004529 Mg2+ binding site [ion binding]; other site 347495004530 G-X-G motif; other site 347495004531 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 347495004532 flagellar motor switch protein; Reviewed; Region: PRK06782 347495004533 CheC-like family; Region: CheC; pfam04509 347495004534 CheC-like family; Region: CheC; pfam04509 347495004535 CheC-like family; Region: CheC; pfam04509 347495004536 CheC-like family; Region: CheC; pfam04509 347495004537 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 347495004538 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 347495004539 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 347495004540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495004541 Protein of unknown function (DUF327); Region: DUF327; pfam03885 347495004542 Glutamate-cysteine ligase; Region: GshA; pfam08886 347495004543 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 347495004544 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 347495004545 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 347495004546 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 347495004547 flagellar capping protein; Validated; Region: fliD; PRK06798 347495004548 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 347495004549 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 347495004550 Flagellar protein FliS; Region: FliS; cl00654 347495004551 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 347495004552 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 347495004553 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 347495004554 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 347495004555 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 347495004556 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 347495004557 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 347495004558 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 347495004559 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 347495004560 FliG C-terminal domain; Region: FliG_C; pfam01706 347495004561 flagellar assembly protein H; Validated; Region: fliH; PRK06800 347495004562 Flagellar assembly protein FliH; Region: FliH; pfam02108 347495004563 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 347495004564 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 347495004565 Walker A motif; other site 347495004566 ATP binding site [chemical binding]; other site 347495004567 Walker B motif; other site 347495004568 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 347495004569 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 347495004570 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 347495004571 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 347495004572 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 347495004573 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 347495004574 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 347495004575 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 347495004576 Response regulator receiver domain; Region: Response_reg; pfam00072 347495004577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495004578 active site 347495004579 phosphorylation site [posttranslational modification] 347495004580 intermolecular recognition site; other site 347495004581 dimerization interface [polypeptide binding]; other site 347495004582 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 347495004583 flagellin; Provisional; Region: PRK12807 347495004584 flagellin; Provisional; Region: PRK12807 347495004585 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 347495004586 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 347495004587 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 347495004588 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 347495004589 N-acetyl-D-glucosamine binding site [chemical binding]; other site 347495004590 catalytic residue [active] 347495004591 flagellar motor switch protein; Validated; Region: PRK06789 347495004592 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 347495004593 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 347495004594 flagellar motor switch protein; Validated; Region: PRK06788 347495004595 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 347495004596 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 347495004597 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 347495004598 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 347495004599 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 347495004600 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 347495004601 FHIPEP family; Region: FHIPEP; pfam00771 347495004602 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 347495004603 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 347495004604 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 347495004605 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 347495004606 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 347495004607 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 347495004608 Predicted transcriptional regulators [Transcription]; Region: COG1378 347495004609 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 347495004610 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 347495004611 C-terminal domain interface [polypeptide binding]; other site 347495004612 sugar binding site [chemical binding]; other site 347495004613 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 347495004614 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 347495004615 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 347495004616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495004617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495004618 Dienelactone hydrolase family; Region: DLH; pfam01738 347495004619 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 347495004620 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 347495004621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495004622 non-specific DNA binding site [nucleotide binding]; other site 347495004623 salt bridge; other site 347495004624 sequence-specific DNA binding site [nucleotide binding]; other site 347495004625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495004626 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495004627 putative substrate translocation pore; other site 347495004628 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 347495004629 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495004630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495004631 dimerization interface [polypeptide binding]; other site 347495004632 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 347495004633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495004634 Walker A/P-loop; other site 347495004635 ATP binding site [chemical binding]; other site 347495004636 Q-loop/lid; other site 347495004637 ABC transporter signature motif; other site 347495004638 Walker B; other site 347495004639 D-loop; other site 347495004640 H-loop/switch region; other site 347495004641 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 347495004642 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 347495004643 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 347495004644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495004645 dimer interface [polypeptide binding]; other site 347495004646 conserved gate region; other site 347495004647 putative PBP binding loops; other site 347495004648 ABC-ATPase subunit interface; other site 347495004649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495004650 dimer interface [polypeptide binding]; other site 347495004651 conserved gate region; other site 347495004652 putative PBP binding loops; other site 347495004653 ABC-ATPase subunit interface; other site 347495004654 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 347495004655 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 347495004656 Beta-Casp domain; Region: Beta-Casp; smart01027 347495004657 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 347495004658 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 347495004659 short chain dehydrogenase; Provisional; Region: PRK08226 347495004660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495004661 NAD(P) binding site [chemical binding]; other site 347495004662 active site 347495004663 Cupin; Region: Cupin_1; smart00835 347495004664 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 347495004665 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 347495004666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495004667 catalytic core [active] 347495004668 hypothetical protein; Provisional; Region: PRK09272 347495004669 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495004670 MarR family; Region: MarR_2; pfam12802 347495004671 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 347495004672 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 347495004673 active site 347495004674 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 347495004675 dimer interface [polypeptide binding]; other site 347495004676 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 347495004677 Ligand Binding Site [chemical binding]; other site 347495004678 Molecular Tunnel; other site 347495004679 RNA polymerase factor sigma-70; Validated; Region: PRK06811 347495004680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495004681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495004682 DNA binding residues [nucleotide binding] 347495004683 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 347495004684 VPS10 domain; Region: VPS10; smart00602 347495004685 VPS10 domain; Region: VPS10; smart00602 347495004686 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 347495004687 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 347495004688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495004689 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 347495004690 DNA-binding site [nucleotide binding]; DNA binding site 347495004691 FCD domain; Region: FCD; pfam07729 347495004692 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495004693 EamA-like transporter family; Region: EamA; pfam00892 347495004694 EamA-like transporter family; Region: EamA; pfam00892 347495004695 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 347495004696 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 347495004697 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 347495004698 Predicted permeases [General function prediction only]; Region: COG0701 347495004699 TIGR03943 family protein; Region: TIGR03943 347495004700 Methyltransferase domain; Region: Methyltransf_24; pfam13578 347495004701 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 347495004702 fumarate hydratase; Reviewed; Region: fumC; PRK00485 347495004703 Class II fumarases; Region: Fumarase_classII; cd01362 347495004704 active site 347495004705 tetramer interface [polypeptide binding]; other site 347495004706 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 347495004707 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 347495004708 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 347495004709 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 347495004710 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 347495004711 active site pocket [active] 347495004712 oxyanion hole [active] 347495004713 catalytic triad [active] 347495004714 active site nucleophile [active] 347495004715 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 347495004716 Penicillinase repressor; Region: Pencillinase_R; pfam03965 347495004717 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 347495004718 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 347495004719 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 347495004720 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 347495004721 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 347495004722 catalytic residues [active] 347495004723 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 347495004724 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 347495004725 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495004726 non-specific DNA binding site [nucleotide binding]; other site 347495004727 salt bridge; other site 347495004728 sequence-specific DNA binding site [nucleotide binding]; other site 347495004729 Cupin domain; Region: Cupin_2; pfam07883 347495004730 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 347495004731 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 347495004732 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 347495004733 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 347495004734 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495004735 catalytic residue [active] 347495004736 Protein of unknown function (DUF445); Region: DUF445; pfam04286 347495004737 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 347495004738 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495004739 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495004740 DNA binding residues [nucleotide binding] 347495004741 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495004742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495004743 active site 347495004744 phosphorylation site [posttranslational modification] 347495004745 intermolecular recognition site; other site 347495004746 dimerization interface [polypeptide binding]; other site 347495004747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495004748 DNA binding residues [nucleotide binding] 347495004749 dimerization interface [polypeptide binding]; other site 347495004750 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495004751 Histidine kinase; Region: HisKA_3; pfam07730 347495004752 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495004753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495004754 Walker A/P-loop; other site 347495004755 ATP binding site [chemical binding]; other site 347495004756 Q-loop/lid; other site 347495004757 ABC transporter signature motif; other site 347495004758 Walker B; other site 347495004759 D-loop; other site 347495004760 H-loop/switch region; other site 347495004761 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 347495004762 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 347495004763 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 347495004764 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 347495004765 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 347495004766 PLD-like domain; Region: PLDc_2; pfam13091 347495004767 putative active site [active] 347495004768 catalytic site [active] 347495004769 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 347495004770 PLD-like domain; Region: PLDc_2; pfam13091 347495004771 putative active site [active] 347495004772 catalytic site [active] 347495004773 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 347495004774 putative nucleotide binding site [chemical binding]; other site 347495004775 uridine monophosphate binding site [chemical binding]; other site 347495004776 homohexameric interface [polypeptide binding]; other site 347495004777 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 347495004778 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 347495004779 aspartate ammonia-lyase; Provisional; Region: PRK14515 347495004780 Aspartase; Region: Aspartase; cd01357 347495004781 active sites [active] 347495004782 tetramer interface [polypeptide binding]; other site 347495004783 malate dehydrogenase; Provisional; Region: PRK13529 347495004784 Malic enzyme, N-terminal domain; Region: malic; pfam00390 347495004785 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 347495004786 NAD(P) binding site [chemical binding]; other site 347495004787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495004788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495004789 ATP binding site [chemical binding]; other site 347495004790 Mg2+ binding site [ion binding]; other site 347495004791 G-X-G motif; other site 347495004792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495004793 Response regulator receiver domain; Region: Response_reg; pfam00072 347495004794 active site 347495004795 phosphorylation site [posttranslational modification] 347495004796 intermolecular recognition site; other site 347495004797 dimerization interface [polypeptide binding]; other site 347495004798 YcbB domain; Region: YcbB; pfam08664 347495004799 SWIM zinc finger; Region: SWIM; pfam04434 347495004800 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 347495004801 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 347495004802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495004803 ATP binding site [chemical binding]; other site 347495004804 putative Mg++ binding site [ion binding]; other site 347495004805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495004806 nucleotide binding region [chemical binding]; other site 347495004807 ATP-binding site [chemical binding]; other site 347495004808 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 347495004809 dimer interface [polypeptide binding]; other site 347495004810 active site 347495004811 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495004812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495004813 non-specific DNA binding site [nucleotide binding]; other site 347495004814 salt bridge; other site 347495004815 sequence-specific DNA binding site [nucleotide binding]; other site 347495004816 aspartate kinase; Reviewed; Region: PRK06635 347495004817 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 347495004818 putative nucleotide binding site [chemical binding]; other site 347495004819 putative catalytic residues [active] 347495004820 putative Mg ion binding site [ion binding]; other site 347495004821 putative aspartate binding site [chemical binding]; other site 347495004822 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 347495004823 putative allosteric regulatory site; other site 347495004824 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 347495004825 putative allosteric regulatory residue; other site 347495004826 DoxX-like family; Region: DoxX_3; pfam13781 347495004827 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 347495004828 YndJ-like protein; Region: YndJ; pfam14158 347495004829 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 347495004830 putative active site [active] 347495004831 nucleotide binding site [chemical binding]; other site 347495004832 nudix motif; other site 347495004833 putative metal binding site [ion binding]; other site 347495004834 S-layer homology domain; Region: SLH; pfam00395 347495004835 S-layer homology domain; Region: SLH; pfam00395 347495004836 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 347495004837 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 347495004838 active site 347495004839 metal binding site [ion binding]; metal-binding site 347495004840 S-layer homology domain; Region: SLH; pfam00395 347495004841 S-layer homology domain; Region: SLH; pfam00395 347495004842 S-layer homology domain; Region: SLH; pfam00395 347495004843 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 347495004844 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495004845 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495004846 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 347495004847 Carbon starvation protein CstA; Region: CstA; pfam02554 347495004848 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 347495004849 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 347495004850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495004851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495004852 putative substrate translocation pore; other site 347495004853 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 347495004854 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 347495004855 dimer interface [polypeptide binding]; other site 347495004856 active site 347495004857 CoA binding pocket [chemical binding]; other site 347495004858 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 347495004859 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 347495004860 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 347495004861 HflX GTPase family; Region: HflX; cd01878 347495004862 G1 box; other site 347495004863 GTP/Mg2+ binding site [chemical binding]; other site 347495004864 Switch I region; other site 347495004865 G2 box; other site 347495004866 G3 box; other site 347495004867 Switch II region; other site 347495004868 G4 box; other site 347495004869 G5 box; other site 347495004870 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495004871 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495004872 peptide binding site [polypeptide binding]; other site 347495004873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495004874 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495004875 putative substrate translocation pore; other site 347495004876 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 347495004877 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 347495004878 dimer interface [polypeptide binding]; other site 347495004879 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495004880 catalytic residue [active] 347495004881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495004882 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495004883 Coenzyme A binding pocket [chemical binding]; other site 347495004884 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 347495004885 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 347495004886 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 347495004887 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 347495004888 Na2 binding site [ion binding]; other site 347495004889 putative substrate binding site 1 [chemical binding]; other site 347495004890 Na binding site 1 [ion binding]; other site 347495004891 putative substrate binding site 2 [chemical binding]; other site 347495004892 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495004893 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 347495004894 NodB motif; other site 347495004895 putative active site [active] 347495004896 putative catalytic site [active] 347495004897 putative Zn binding site [ion binding]; other site 347495004898 Mor transcription activator family; Region: Mor; cl02360 347495004899 Predicted membrane protein [Function unknown]; Region: COG2323 347495004900 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 347495004901 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 347495004902 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 347495004903 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 347495004904 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 347495004905 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 347495004906 methionine sulfoxide reductase A; Provisional; Region: PRK14054 347495004907 short chain dehydrogenase; Provisional; Region: PRK12747 347495004908 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 347495004909 NADP binding site [chemical binding]; other site 347495004910 homodimer interface [polypeptide binding]; other site 347495004911 active site 347495004912 substrate binding site [chemical binding]; other site 347495004913 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 347495004914 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 347495004915 homodimer interface [polypeptide binding]; other site 347495004916 substrate-cofactor binding pocket; other site 347495004917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495004918 catalytic residue [active] 347495004919 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 347495004920 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 347495004921 PYR/PP interface [polypeptide binding]; other site 347495004922 dimer interface [polypeptide binding]; other site 347495004923 TPP binding site [chemical binding]; other site 347495004924 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 347495004925 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 347495004926 TPP-binding site [chemical binding]; other site 347495004927 dimer interface [polypeptide binding]; other site 347495004928 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 347495004929 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 347495004930 putative valine binding site [chemical binding]; other site 347495004931 dimer interface [polypeptide binding]; other site 347495004932 ketol-acid reductoisomerase; Provisional; Region: PRK05479 347495004933 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 347495004934 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 347495004935 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 347495004936 threonine dehydratase; Validated; Region: PRK08639 347495004937 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 347495004938 tetramer interface [polypeptide binding]; other site 347495004939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495004940 catalytic residue [active] 347495004941 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 347495004942 putative Ile/Val binding site [chemical binding]; other site 347495004943 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 347495004944 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 347495004945 putative active site [active] 347495004946 putative metal binding site [ion binding]; other site 347495004947 Protein of unknown function (DUF554); Region: DUF554; pfam04474 347495004948 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495004949 Coenzyme A binding pocket [chemical binding]; other site 347495004950 drug efflux system protein MdtG; Provisional; Region: PRK09874 347495004951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495004952 putative substrate translocation pore; other site 347495004953 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 347495004954 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 347495004955 putative active site [active] 347495004956 metal binding site [ion binding]; metal-binding site 347495004957 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 347495004958 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495004959 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 347495004960 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 347495004961 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 347495004962 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 347495004963 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495004964 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495004965 LytTr DNA-binding domain; Region: LytTR; pfam04397 347495004966 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 347495004967 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 347495004968 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 347495004969 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 347495004970 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495004971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495004972 Coenzyme A binding pocket [chemical binding]; other site 347495004973 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 347495004974 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 347495004975 active site 347495004976 putative substrate binding pocket [chemical binding]; other site 347495004977 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 347495004978 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495004979 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 347495004980 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495004981 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495004982 peptide binding site [polypeptide binding]; other site 347495004983 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 347495004984 hypothetical protein; Provisional; Region: PRK06922 347495004985 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495004986 S-adenosylmethionine binding site [chemical binding]; other site 347495004987 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 347495004988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495004989 FeS/SAM binding site; other site 347495004990 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 347495004991 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495004992 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495004993 Coenzyme A binding pocket [chemical binding]; other site 347495004994 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495004996 active site 347495004997 phosphorylation site [posttranslational modification] 347495004998 intermolecular recognition site; other site 347495004999 dimerization interface [polypeptide binding]; other site 347495005000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495005001 DNA binding site [nucleotide binding] 347495005002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495005003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495005004 dimerization interface [polypeptide binding]; other site 347495005005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495005006 dimer interface [polypeptide binding]; other site 347495005007 phosphorylation site [posttranslational modification] 347495005008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495005009 ATP binding site [chemical binding]; other site 347495005010 Mg2+ binding site [ion binding]; other site 347495005011 G-X-G motif; other site 347495005012 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495005013 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495005014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495005015 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 347495005016 manganese transport protein MntH; Reviewed; Region: PRK00701 347495005017 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 347495005018 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 347495005019 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 347495005020 active site residue [active] 347495005021 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 347495005022 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 347495005023 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 347495005024 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 347495005025 Amino acid permease; Region: AA_permease_2; pfam13520 347495005026 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495005027 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495005028 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495005029 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 347495005030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495005031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495005032 Walker A/P-loop; other site 347495005033 ATP binding site [chemical binding]; other site 347495005034 Q-loop/lid; other site 347495005035 ABC transporter signature motif; other site 347495005036 Walker B; other site 347495005037 D-loop; other site 347495005038 H-loop/switch region; other site 347495005039 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 347495005040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 347495005041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 347495005042 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 347495005043 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 347495005044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495005045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495005046 active site 347495005047 phosphorylation site [posttranslational modification] 347495005048 intermolecular recognition site; other site 347495005049 dimerization interface [polypeptide binding]; other site 347495005050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495005051 DNA binding site [nucleotide binding] 347495005052 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495005053 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495005054 dimer interface [polypeptide binding]; other site 347495005055 phosphorylation site [posttranslational modification] 347495005056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495005057 ATP binding site [chemical binding]; other site 347495005058 Mg2+ binding site [ion binding]; other site 347495005059 G-X-G motif; other site 347495005060 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 347495005061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495005062 DNA binding residues [nucleotide binding] 347495005063 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 347495005064 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 347495005065 intersubunit interface [polypeptide binding]; other site 347495005066 active site 347495005067 catalytic residue [active] 347495005068 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 347495005069 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495005070 Nucleoside recognition; Region: Gate; pfam07670 347495005071 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495005072 potential frameshift: common BLAST hit: gi|229601292|ref|YP_002866301.1| pyrimidine-nucleoside phosphorylase 347495005073 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 347495005074 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 347495005075 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 347495005076 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 347495005077 active site 347495005078 catalytic motif [active] 347495005079 Zn binding site [ion binding]; other site 347495005080 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 347495005081 hypothetical protein; Provisional; Region: PRK01631 347495005082 Family description; Region: DsbD_2; pfam13386 347495005083 VPS10 domain; Region: VPS10; smart00602 347495005084 proline aminopeptidase P II; Provisional; Region: PRK10879 347495005085 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 347495005086 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 347495005087 active site 347495005088 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 347495005089 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 347495005090 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 347495005091 Multicopper oxidase; Region: Cu-oxidase; pfam00394 347495005092 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 347495005093 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005094 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005095 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005096 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005097 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005098 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495005099 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495005100 DNA topoisomerase III; Provisional; Region: PRK07726 347495005101 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 347495005102 active site 347495005103 putative interdomain interaction site [polypeptide binding]; other site 347495005104 putative metal-binding site [ion binding]; other site 347495005105 putative nucleotide binding site [chemical binding]; other site 347495005106 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 347495005107 domain I; other site 347495005108 DNA binding groove [nucleotide binding] 347495005109 phosphate binding site [ion binding]; other site 347495005110 domain II; other site 347495005111 domain III; other site 347495005112 nucleotide binding site [chemical binding]; other site 347495005113 catalytic site [active] 347495005114 domain IV; other site 347495005115 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 347495005116 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 347495005117 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 347495005118 Sodium Bile acid symporter family; Region: SBF; cl17470 347495005119 azoreductase; Provisional; Region: PRK13555 347495005120 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 347495005121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495005122 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 347495005123 dimer interface [polypeptide binding]; other site 347495005124 substrate binding site [chemical binding]; other site 347495005125 metal binding site [ion binding]; metal-binding site 347495005126 potential frameshift: common BLAST hit: gi|118477373|ref|YP_894524.1| copper resistance protein 347495005127 CopC domain; Region: CopC; pfam04234 347495005128 Copper resistance protein D; Region: CopD; cl00563 347495005129 YtkA-like; Region: YtkA; pfam13115 347495005130 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 347495005131 EamA-like transporter family; Region: EamA; pfam00892 347495005132 EamA-like transporter family; Region: EamA; pfam00892 347495005133 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495005134 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495005135 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495005136 dimerization interface [polypeptide binding]; other site 347495005137 Predicted transcriptional regulator [Transcription]; Region: COG1959 347495005138 Transcriptional regulator; Region: Rrf2; pfam02082 347495005139 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 347495005140 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 347495005141 catalytic residues [active] 347495005142 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 347495005143 dimer interface [polypeptide binding]; other site 347495005144 FMN binding site [chemical binding]; other site 347495005145 amidase; Provisional; Region: PRK06707 347495005146 Amidase; Region: Amidase; cl11426 347495005147 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 347495005148 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 347495005149 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 347495005150 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495005151 NAD binding site [chemical binding]; other site 347495005152 dimer interface [polypeptide binding]; other site 347495005153 substrate binding site [chemical binding]; other site 347495005154 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 347495005155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495005156 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 347495005157 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 347495005158 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 347495005159 S-layer homology domain; Region: SLH; pfam00395 347495005160 S-layer homology domain; Region: SLH; pfam00395 347495005161 S-layer homology domain; Region: SLH; pfam00395 347495005162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495005163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495005164 acyl-CoA synthetase; Validated; Region: PRK06839 347495005165 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495005166 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 347495005167 acyl-activating enzyme (AAE) consensus motif; other site 347495005168 putative AMP binding site [chemical binding]; other site 347495005169 putative active site [active] 347495005170 putative CoA binding site [chemical binding]; other site 347495005171 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 347495005172 dimer interaction site [polypeptide binding]; other site 347495005173 substrate-binding tunnel; other site 347495005174 active site 347495005175 catalytic site [active] 347495005176 substrate binding site [chemical binding]; other site 347495005177 hypothetical protein; Validated; Region: PRK06840 347495005178 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 347495005179 active site 347495005180 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 347495005181 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 347495005182 putative ligand binding site [chemical binding]; other site 347495005183 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 347495005184 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 347495005185 Walker A/P-loop; other site 347495005186 ATP binding site [chemical binding]; other site 347495005187 Q-loop/lid; other site 347495005188 ABC transporter signature motif; other site 347495005189 Walker B; other site 347495005190 D-loop; other site 347495005191 H-loop/switch region; other site 347495005192 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 347495005193 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 347495005194 Walker A/P-loop; other site 347495005195 ATP binding site [chemical binding]; other site 347495005196 Q-loop/lid; other site 347495005197 ABC transporter signature motif; other site 347495005198 Walker B; other site 347495005199 D-loop; other site 347495005200 H-loop/switch region; other site 347495005201 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 347495005202 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 347495005203 TM-ABC transporter signature motif; other site 347495005204 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 347495005205 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 347495005206 TM-ABC transporter signature motif; other site 347495005207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495005208 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 347495005209 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 347495005210 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 347495005211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495005212 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495005213 putative Zn2+ binding site [ion binding]; other site 347495005214 putative DNA binding site [nucleotide binding]; other site 347495005215 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 347495005216 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 347495005217 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 347495005218 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 347495005219 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 347495005220 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 347495005221 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 347495005222 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 347495005223 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495005224 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 347495005225 Walker A/P-loop; other site 347495005226 ATP binding site [chemical binding]; other site 347495005227 Q-loop/lid; other site 347495005228 ABC transporter signature motif; other site 347495005229 Walker B; other site 347495005230 D-loop; other site 347495005231 H-loop/switch region; other site 347495005232 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 347495005233 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495005234 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 347495005235 Walker A/P-loop; other site 347495005236 ATP binding site [chemical binding]; other site 347495005237 Q-loop/lid; other site 347495005238 ABC transporter signature motif; other site 347495005239 Walker B; other site 347495005240 D-loop; other site 347495005241 H-loop/switch region; other site 347495005242 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 347495005243 putative dimer interface [polypeptide binding]; other site 347495005244 catalytic triad [active] 347495005245 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495005246 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 347495005247 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 347495005248 dimer interface [polypeptide binding]; other site 347495005249 FMN binding site [chemical binding]; other site 347495005250 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005251 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005252 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495005253 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 347495005254 NlpC/P60 family; Region: NLPC_P60; pfam00877 347495005255 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 347495005256 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495005257 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495005258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495005259 Walker A/P-loop; other site 347495005260 ATP binding site [chemical binding]; other site 347495005261 Q-loop/lid; other site 347495005262 ABC transporter signature motif; other site 347495005263 Walker B; other site 347495005264 D-loop; other site 347495005265 H-loop/switch region; other site 347495005266 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495005267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495005268 active site 347495005269 phosphorylation site [posttranslational modification] 347495005270 intermolecular recognition site; other site 347495005271 dimerization interface [polypeptide binding]; other site 347495005272 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495005273 DNA binding site [nucleotide binding] 347495005274 Protein of unknown function (DUF475); Region: DUF475; cl17481 347495005275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495005276 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495005277 dimerization interface [polypeptide binding]; other site 347495005278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495005279 dimer interface [polypeptide binding]; other site 347495005280 phosphorylation site [posttranslational modification] 347495005281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495005282 ATP binding site [chemical binding]; other site 347495005283 Mg2+ binding site [ion binding]; other site 347495005284 G-X-G motif; other site 347495005285 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 347495005286 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 347495005287 classical (c) SDRs; Region: SDR_c; cd05233 347495005288 NAD(P) binding site [chemical binding]; other site 347495005289 active site 347495005290 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 347495005291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495005292 S-adenosylmethionine binding site [chemical binding]; other site 347495005293 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 347495005294 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495005295 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 347495005296 NodB motif; other site 347495005297 active site 347495005298 catalytic site [active] 347495005299 metal binding site [ion binding]; metal-binding site 347495005300 SdpI/YhfL protein family; Region: SdpI; pfam13630 347495005301 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 347495005302 nudix motif; other site 347495005303 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 347495005304 homoserine dehydrogenase; Provisional; Region: PRK06349 347495005305 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 347495005306 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 347495005307 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 347495005308 threonine synthase; Reviewed; Region: PRK06721 347495005309 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 347495005310 homodimer interface [polypeptide binding]; other site 347495005311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495005312 catalytic residue [active] 347495005313 homoserine kinase; Provisional; Region: PRK01212 347495005314 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 347495005315 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 347495005316 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 347495005317 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 347495005318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495005319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495005320 active site 347495005321 phosphorylation site [posttranslational modification] 347495005322 intermolecular recognition site; other site 347495005323 dimerization interface [polypeptide binding]; other site 347495005324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495005325 DNA binding site [nucleotide binding] 347495005326 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495005327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495005328 dimerization interface [polypeptide binding]; other site 347495005329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495005330 dimer interface [polypeptide binding]; other site 347495005331 phosphorylation site [posttranslational modification] 347495005332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495005333 ATP binding site [chemical binding]; other site 347495005334 Mg2+ binding site [ion binding]; other site 347495005335 G-X-G motif; other site 347495005336 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495005337 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 347495005338 NodB motif; other site 347495005339 active site 347495005340 catalytic site [active] 347495005341 Zn binding site [ion binding]; other site 347495005342 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 347495005343 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 347495005344 MgtC family; Region: MgtC; pfam02308 347495005345 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495005346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005347 Coenzyme A binding pocket [chemical binding]; other site 347495005348 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 347495005349 IucA / IucC family; Region: IucA_IucC; pfam04183 347495005350 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 347495005351 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 347495005352 IucA / IucC family; Region: IucA_IucC; pfam04183 347495005353 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 347495005354 acyl-CoA synthetase; Validated; Region: PRK08308 347495005355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495005356 acyl-activating enzyme (AAE) consensus motif; other site 347495005357 AMP binding site [chemical binding]; other site 347495005358 active site 347495005359 CoA binding site [chemical binding]; other site 347495005360 acyl carrier protein; Provisional; Region: PRK07639 347495005361 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 347495005362 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495005363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495005364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495005365 putative substrate translocation pore; other site 347495005366 Lysine efflux permease [General function prediction only]; Region: COG1279 347495005367 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495005368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495005369 DNA-binding site [nucleotide binding]; DNA binding site 347495005370 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495005371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495005372 homodimer interface [polypeptide binding]; other site 347495005373 catalytic residue [active] 347495005374 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 347495005375 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 347495005376 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 347495005377 active site 347495005378 nucleophile elbow; other site 347495005379 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 347495005380 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 347495005381 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 347495005382 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 347495005383 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 347495005384 nudix motif; other site 347495005385 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 347495005386 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 347495005387 homodimer interface [polypeptide binding]; other site 347495005388 NAD binding pocket [chemical binding]; other site 347495005389 ATP binding pocket [chemical binding]; other site 347495005390 Mg binding site [ion binding]; other site 347495005391 active-site loop [active] 347495005392 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495005393 FtsX-like permease family; Region: FtsX; pfam02687 347495005394 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 347495005395 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 347495005396 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 347495005397 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 347495005398 active site 347495005399 catalytic residues [active] 347495005400 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495005401 dimerization interface [polypeptide binding]; other site 347495005402 putative DNA binding site [nucleotide binding]; other site 347495005403 putative Zn2+ binding site [ion binding]; other site 347495005404 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 347495005405 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 347495005406 active site 347495005407 catalytic tetrad [active] 347495005408 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 347495005409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495005410 putative substrate translocation pore; other site 347495005411 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 347495005412 Protein of unknown function (DUF664); Region: DUF664; pfam04978 347495005413 DinB superfamily; Region: DinB_2; pfam12867 347495005414 GTPase RsgA; Reviewed; Region: PRK01889 347495005415 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 347495005416 RNA binding site [nucleotide binding]; other site 347495005417 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 347495005418 GTPase/Zn-binding domain interface [polypeptide binding]; other site 347495005419 GTP/Mg2+ binding site [chemical binding]; other site 347495005420 G4 box; other site 347495005421 G5 box; other site 347495005422 G1 box; other site 347495005423 Switch I region; other site 347495005424 G2 box; other site 347495005425 G3 box; other site 347495005426 Switch II region; other site 347495005427 Tar ligand binding domain homologue; Region: TarH; pfam02203 347495005428 Cache domain; Region: Cache_1; pfam02743 347495005429 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 347495005430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495005431 dimerization interface [polypeptide binding]; other site 347495005432 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495005433 dimer interface [polypeptide binding]; other site 347495005434 putative CheW interface [polypeptide binding]; other site 347495005435 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 347495005436 Uncharacterized membrane protein [Function unknown]; Region: COG3949 347495005437 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 347495005438 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 347495005439 dimerization interface [polypeptide binding]; other site 347495005440 DPS ferroxidase diiron center [ion binding]; other site 347495005441 ion pore; other site 347495005442 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 347495005443 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 347495005444 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 347495005445 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 347495005446 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 347495005447 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 347495005448 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495005449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495005450 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495005451 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 347495005452 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 347495005453 active site 347495005454 catalytic tetrad [active] 347495005455 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 347495005456 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 347495005457 P-loop, Walker A motif; other site 347495005458 Base recognition motif; other site 347495005459 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 347495005460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495005461 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005462 Coenzyme A binding pocket [chemical binding]; other site 347495005463 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 347495005464 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 347495005465 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 347495005466 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 347495005467 metal binding site [ion binding]; metal-binding site 347495005468 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 347495005469 NADH(P)-binding; Region: NAD_binding_10; pfam13460 347495005470 NAD binding site [chemical binding]; other site 347495005471 active site 347495005472 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 347495005473 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 347495005474 active site 347495005475 FMN binding site [chemical binding]; other site 347495005476 substrate binding site [chemical binding]; other site 347495005477 homotetramer interface [polypeptide binding]; other site 347495005478 catalytic residue [active] 347495005479 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 347495005480 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 347495005481 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 347495005482 DNA binding site [nucleotide binding] 347495005483 active site 347495005484 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 347495005485 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495005486 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495005487 peptide binding site [polypeptide binding]; other site 347495005488 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 347495005489 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495005490 active site 347495005491 metal binding site [ion binding]; metal-binding site 347495005492 short chain dehydrogenase; Provisional; Region: PRK08309 347495005493 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495005494 catalytic core [active] 347495005495 CotH protein; Region: CotH; pfam08757 347495005496 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 347495005497 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 347495005498 nudix motif; other site 347495005499 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 347495005500 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495005501 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 347495005502 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 347495005503 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 347495005504 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 347495005505 Cl binding site [ion binding]; other site 347495005506 oligomer interface [polypeptide binding]; other site 347495005507 Predicted permeases [General function prediction only]; Region: COG0701 347495005508 Predicted membrane protein [Function unknown]; Region: COG3689 347495005509 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 347495005510 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 347495005511 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 347495005512 putative active site [active] 347495005513 catalytic site [active] 347495005514 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 347495005515 putative active site [active] 347495005516 catalytic site [active] 347495005517 Coat F domain; Region: Coat_F; pfam07875 347495005518 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 347495005519 NADH(P)-binding; Region: NAD_binding_10; pfam13460 347495005520 NAD binding site [chemical binding]; other site 347495005521 substrate binding site [chemical binding]; other site 347495005522 putative active site [active] 347495005523 Protein of unknown function (DUF456); Region: DUF456; pfam04306 347495005524 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 347495005525 Domain of unknown function DUF21; Region: DUF21; pfam01595 347495005526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 347495005527 Transporter associated domain; Region: CorC_HlyC; smart01091 347495005528 FOG: CBS domain [General function prediction only]; Region: COG0517 347495005529 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 347495005530 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 347495005531 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 347495005532 dimer interface [polypeptide binding]; other site 347495005533 putative tRNA-binding site [nucleotide binding]; other site 347495005534 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 347495005535 DinB superfamily; Region: DinB_2; pfam12867 347495005536 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 347495005537 stage II sporulation protein P; Region: spore_II_P; TIGR02867 347495005538 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495005539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005540 Coenzyme A binding pocket [chemical binding]; other site 347495005541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495005542 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 347495005543 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 347495005544 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+ for their activity and contain a highly...; Region: Nudix_Hydrolase_6; cd04663 347495005545 nudix motif; other site 347495005546 amidase; Provisional; Region: PRK06828 347495005547 Amidase; Region: Amidase; pfam01425 347495005548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495005549 putative substrate translocation pore; other site 347495005550 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 347495005551 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 347495005552 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 347495005553 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 347495005554 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 347495005555 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 347495005556 Transcriptional regulator [Transcription]; Region: IclR; COG1414 347495005557 Bacterial transcriptional regulator; Region: IclR; pfam01614 347495005558 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 347495005559 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 347495005560 active site 347495005561 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 347495005562 Amidohydrolase; Region: Amidohydro_2; pfam04909 347495005563 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 347495005564 homotrimer interaction site [polypeptide binding]; other site 347495005565 putative active site [active] 347495005566 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 347495005567 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 347495005568 NAD binding site [chemical binding]; other site 347495005569 catalytic residues [active] 347495005570 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 347495005571 acetaldehyde dehydrogenase; Validated; Region: PRK08300 347495005572 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 347495005573 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 347495005574 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 347495005575 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 347495005576 active site 347495005577 catalytic residues [active] 347495005578 metal binding site [ion binding]; metal-binding site 347495005579 DmpG-like communication domain; Region: DmpG_comm; pfam07836 347495005580 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 347495005581 4-oxalocrotonate tautomerase; Provisional; Region: PRK01964 347495005582 active site 1 [active] 347495005583 dimer interface [polypeptide binding]; other site 347495005584 hexamer interface [polypeptide binding]; other site 347495005585 active site 2 [active] 347495005586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495005587 catalytic core [active] 347495005588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495005589 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495005590 active site 347495005591 motif I; other site 347495005592 motif II; other site 347495005593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495005594 DinB superfamily; Region: DinB_2; pfam12867 347495005595 DinB family; Region: DinB; cl17821 347495005596 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 347495005597 alanine racemase; Reviewed; Region: alr; PRK00053 347495005598 active site 347495005599 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 347495005600 dimer interface [polypeptide binding]; other site 347495005601 substrate binding site [chemical binding]; other site 347495005602 catalytic residues [active] 347495005603 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495005604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495005605 S-adenosylmethionine binding site [chemical binding]; other site 347495005606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005607 Coenzyme A binding pocket [chemical binding]; other site 347495005608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005609 Coenzyme A binding pocket [chemical binding]; other site 347495005610 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 347495005611 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 347495005612 glycosyltransferase, MGT family; Region: MGT; TIGR01426 347495005613 active site 347495005614 TDP-binding site; other site 347495005615 acceptor substrate-binding pocket; other site 347495005616 homodimer interface [polypeptide binding]; other site 347495005617 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495005618 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495005619 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495005620 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495005621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495005622 DNA-binding site [nucleotide binding]; DNA binding site 347495005623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495005624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495005625 homodimer interface [polypeptide binding]; other site 347495005626 catalytic residue [active] 347495005627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005628 Coenzyme A binding pocket [chemical binding]; other site 347495005629 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495005630 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 347495005631 active site 347495005632 metal binding site [ion binding]; metal-binding site 347495005633 Src Homology 3 domain superfamily; Region: SH3; cl17036 347495005634 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 347495005635 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495005636 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005637 Coenzyme A binding pocket [chemical binding]; other site 347495005638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495005639 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 347495005640 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495005641 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005642 Coenzyme A binding pocket [chemical binding]; other site 347495005643 Cupin domain; Region: Cupin_2; cl17218 347495005644 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 347495005645 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 347495005646 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495005647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495005648 S-adenosylmethionine binding site [chemical binding]; other site 347495005649 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 347495005650 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 347495005651 Potassium binding sites [ion binding]; other site 347495005652 Cesium cation binding sites [ion binding]; other site 347495005653 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 347495005654 DEAD-like helicases superfamily; Region: DEXDc; smart00487 347495005655 ATP binding site [chemical binding]; other site 347495005656 putative Mg++ binding site [ion binding]; other site 347495005657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495005658 nucleotide binding region [chemical binding]; other site 347495005659 ATP-binding site [chemical binding]; other site 347495005660 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 347495005661 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495005662 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 347495005663 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495005664 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 347495005665 NADP binding site [chemical binding]; other site 347495005666 dimer interface [polypeptide binding]; other site 347495005667 RNA polymerase sigma factor; Provisional; Region: PRK12543 347495005668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495005669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495005670 DNA binding residues [nucleotide binding] 347495005671 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 347495005672 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 347495005673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495005674 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 347495005675 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 347495005676 catalytic residues [active] 347495005677 dimer interface [polypeptide binding]; other site 347495005678 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 347495005679 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 347495005680 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 347495005681 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 347495005682 Protein of unknown function DUF58; Region: DUF58; pfam01882 347495005683 MoxR-like ATPases [General function prediction only]; Region: COG0714 347495005684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495005685 Walker A motif; other site 347495005686 ATP binding site [chemical binding]; other site 347495005687 Walker B motif; other site 347495005688 arginine finger; other site 347495005689 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 347495005690 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 347495005691 [4Fe-4S] binding site [ion binding]; other site 347495005692 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 347495005693 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 347495005694 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 347495005695 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 347495005696 molybdopterin cofactor binding site; other site 347495005697 nitrate reductase, beta subunit; Region: narH; TIGR01660 347495005698 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 347495005699 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 347495005700 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 347495005701 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 347495005702 ligand binding site [chemical binding]; other site 347495005703 flexible hinge region; other site 347495005704 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 347495005705 putative switch regulator; other site 347495005706 non-specific DNA interactions [nucleotide binding]; other site 347495005707 DNA binding site [nucleotide binding] 347495005708 sequence specific DNA binding site [nucleotide binding]; other site 347495005709 putative cAMP binding site [chemical binding]; other site 347495005710 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 347495005711 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495005712 FeS/SAM binding site; other site 347495005713 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 347495005714 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 347495005715 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 347495005716 ATP binding site [chemical binding]; other site 347495005717 substrate interface [chemical binding]; other site 347495005718 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 347495005719 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 347495005720 dimer interface [polypeptide binding]; other site 347495005721 putative functional site; other site 347495005722 putative MPT binding site; other site 347495005723 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 347495005724 MoaE homodimer interface [polypeptide binding]; other site 347495005725 MoaD interaction [polypeptide binding]; other site 347495005726 active site residues [active] 347495005727 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 347495005728 MoaE interaction surface [polypeptide binding]; other site 347495005729 MoeB interaction surface [polypeptide binding]; other site 347495005730 thiocarboxylated glycine; other site 347495005731 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 347495005732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495005733 putative substrate translocation pore; other site 347495005734 Predicted permeases [General function prediction only]; Region: COG0679 347495005735 precorrin-2 dehydrogenase; Validated; Region: PRK06719 347495005736 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 347495005737 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 347495005738 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 347495005739 putative active site [active] 347495005740 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 347495005741 putative active site [active] 347495005742 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 347495005743 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 347495005744 active site 347495005745 SAM binding site [chemical binding]; other site 347495005746 homodimer interface [polypeptide binding]; other site 347495005747 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 347495005748 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 347495005749 [2Fe-2S] cluster binding site [ion binding]; other site 347495005750 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 347495005751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495005752 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495005753 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 347495005754 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 347495005755 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 347495005756 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 347495005757 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 347495005758 Hemerythrin-like domain; Region: Hr-like; cd12108 347495005759 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 347495005760 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 347495005761 PGAP1-like protein; Region: PGAP1; pfam07819 347495005762 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 347495005763 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 347495005764 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 347495005765 nucleophilic elbow; other site 347495005766 catalytic triad; other site 347495005767 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 347495005768 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495005769 Zn2+ binding site [ion binding]; other site 347495005770 Mg2+ binding site [ion binding]; other site 347495005771 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495005772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495005773 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495005774 ABC transporter; Region: ABC_tran_2; pfam12848 347495005775 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495005776 Bax inhibitor 1 like; Region: BaxI_1; cl17691 347495005777 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 347495005778 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 347495005779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 347495005780 active site 347495005781 DNA binding site [nucleotide binding] 347495005782 Int/Topo IB signature motif; other site 347495005783 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 347495005784 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 347495005785 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 347495005786 catalytic residues [active] 347495005787 catalytic nucleophile [active] 347495005788 Presynaptic Site I dimer interface [polypeptide binding]; other site 347495005789 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 347495005790 Synaptic Flat tetramer interface [polypeptide binding]; other site 347495005791 Synaptic Site I dimer interface [polypeptide binding]; other site 347495005792 DNA binding site [nucleotide binding] 347495005793 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 347495005794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495005795 Walker A motif; other site 347495005796 ATP binding site [chemical binding]; other site 347495005797 Walker B motif; other site 347495005798 arginine finger; other site 347495005799 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 347495005800 Predicted permeases [General function prediction only]; Region: COG0701 347495005801 MarR family; Region: MarR_2; pfam12802 347495005802 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495005803 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 347495005804 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 347495005805 Phosphate transporter family; Region: PHO4; pfam01384 347495005806 SEC-C motif; Region: SEC-C; pfam02810 347495005807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005808 TPR motif; other site 347495005809 binding surface 347495005810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005811 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 347495005812 active site 347495005813 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495005814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495005815 non-specific DNA binding site [nucleotide binding]; other site 347495005816 salt bridge; other site 347495005817 sequence-specific DNA binding site [nucleotide binding]; other site 347495005818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005820 TPR motif; other site 347495005821 binding surface 347495005822 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005823 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005824 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005825 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005826 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 347495005827 B12 binding site [chemical binding]; other site 347495005828 Radical SAM superfamily; Region: Radical_SAM; pfam04055 347495005829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495005830 FeS/SAM binding site; other site 347495005831 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 347495005832 amphipathic channel; other site 347495005833 Asn-Pro-Ala signature motifs; other site 347495005834 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 347495005835 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 347495005836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495005837 Coenzyme A binding pocket [chemical binding]; other site 347495005838 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495005839 dimerization interface [polypeptide binding]; other site 347495005840 putative DNA binding site [nucleotide binding]; other site 347495005841 putative Zn2+ binding site [ion binding]; other site 347495005842 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 347495005843 arsenical-resistance protein; Region: acr3; TIGR00832 347495005844 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 347495005845 Low molecular weight phosphatase family; Region: LMWPc; cd00115 347495005846 active site 347495005847 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 347495005848 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 347495005849 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 347495005850 P loop; other site 347495005851 Nucleotide binding site [chemical binding]; other site 347495005852 DTAP/Switch II; other site 347495005853 Switch I; other site 347495005854 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 347495005855 P loop; other site 347495005856 Nucleotide binding site [chemical binding]; other site 347495005857 DTAP/Switch II; other site 347495005858 Switch I; other site 347495005859 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 347495005860 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 347495005861 active site 347495005862 catalytic residues [active] 347495005863 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495005864 non-specific DNA binding site [nucleotide binding]; other site 347495005865 salt bridge; other site 347495005866 sequence-specific DNA binding site [nucleotide binding]; other site 347495005867 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 347495005868 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 347495005869 dimer interface [polypeptide binding]; other site 347495005870 ssDNA binding site [nucleotide binding]; other site 347495005871 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495005872 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495005873 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495005874 hypothetical protein; Provisional; Region: PRK06753 347495005875 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 347495005876 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 347495005877 Virulence factor; Region: Virulence_fact; pfam13769 347495005878 HEAT repeats; Region: HEAT_2; pfam13646 347495005879 HEAT repeats; Region: HEAT_2; pfam13646 347495005880 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 347495005881 Protein of unknown function, DUF393; Region: DUF393; pfam04134 347495005882 Disulphide isomerase; Region: Disulph_isomer; pfam06491 347495005883 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 347495005884 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 347495005885 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 347495005886 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 347495005887 active site 347495005888 HIGH motif; other site 347495005889 KMSK motif region; other site 347495005890 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 347495005891 tRNA binding surface [nucleotide binding]; other site 347495005892 anticodon binding site; other site 347495005893 Methyltransferase domain; Region: Methyltransf_32; pfam13679 347495005894 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495005895 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495005896 S-adenosylmethionine binding site [chemical binding]; other site 347495005897 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 347495005898 putative catalytic site [active] 347495005899 putative metal binding site [ion binding]; other site 347495005900 putative phosphate binding site [ion binding]; other site 347495005901 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005902 binding surface 347495005903 TPR motif; other site 347495005904 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 347495005905 putative active site [active] 347495005906 TPR repeat; Region: TPR_11; pfam13414 347495005907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005908 binding surface 347495005909 TPR motif; other site 347495005910 Tetratricopeptide repeat; Region: TPR_16; pfam13432 347495005911 TPR repeat; Region: TPR_11; pfam13414 347495005912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005913 binding surface 347495005914 TPR motif; other site 347495005915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005916 TPR motif; other site 347495005917 TPR repeat; Region: TPR_11; pfam13414 347495005918 binding surface 347495005919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005920 binding surface 347495005921 TPR motif; other site 347495005922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005924 binding surface 347495005925 TPR motif; other site 347495005926 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 347495005927 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 347495005928 HIGH motif; other site 347495005929 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 347495005930 active site 347495005931 KMSKS motif; other site 347495005932 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 347495005933 tRNA binding surface [nucleotide binding]; other site 347495005934 anticodon binding site; other site 347495005935 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 347495005936 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495005937 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 347495005938 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 347495005939 Zn binding site [ion binding]; other site 347495005940 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 347495005941 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 347495005942 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 347495005943 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 347495005944 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 347495005945 Dimer interface [polypeptide binding]; other site 347495005946 anticodon binding site; other site 347495005947 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 347495005948 homodimer interface [polypeptide binding]; other site 347495005949 motif 1; other site 347495005950 motif 2; other site 347495005951 active site 347495005952 motif 3; other site 347495005953 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 347495005954 metal ion-dependent adhesion site (MIDAS); other site 347495005955 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 347495005956 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 347495005957 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 347495005958 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 347495005959 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495005960 Walker A motif; other site 347495005961 ATP binding site [chemical binding]; other site 347495005962 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 347495005963 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 347495005964 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 347495005965 active site 347495005966 ATP binding site [chemical binding]; other site 347495005967 substrate binding site [chemical binding]; other site 347495005968 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005969 binding surface 347495005970 TPR motif; other site 347495005971 TPR repeat; Region: TPR_11; pfam13414 347495005972 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005973 binding surface 347495005974 TPR motif; other site 347495005975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495005976 binding surface 347495005977 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495005978 TPR motif; other site 347495005979 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 347495005980 SseB protein; Region: SseB; cl06279 347495005981 Proteins of 100 residues with WXG; Region: WXG100; cl02005 347495005982 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 347495005983 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 347495005984 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 347495005985 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 347495005986 catalytic residues [active] 347495005987 catalytic nucleophile [active] 347495005988 Recombinase; Region: Recombinase; pfam07508 347495005989 Transposase; Region: DEDD_Tnp_IS110; pfam01548 347495005990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 347495005991 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 347495005992 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 347495005993 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 347495005994 Protein of unknown function, DUF600; Region: DUF600; pfam04634 347495005995 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 347495005996 Immunity protein Imm3; Region: Imm3; pfam14425 347495005997 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 347495005998 glycerate kinase; Region: TIGR00045 347495005999 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 347495006000 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 347495006001 transmembrane helices; other site 347495006002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495006003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495006004 active site 347495006005 phosphorylation site [posttranslational modification] 347495006006 intermolecular recognition site; other site 347495006007 dimerization interface [polypeptide binding]; other site 347495006008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495006009 DNA binding site [nucleotide binding] 347495006010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495006011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495006012 dimerization interface [polypeptide binding]; other site 347495006013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495006014 dimer interface [polypeptide binding]; other site 347495006015 phosphorylation site [posttranslational modification] 347495006016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495006017 ATP binding site [chemical binding]; other site 347495006018 Mg2+ binding site [ion binding]; other site 347495006019 G-X-G motif; other site 347495006020 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 347495006021 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 347495006022 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 347495006023 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 347495006024 Na2 binding site [ion binding]; other site 347495006025 putative substrate binding site 1 [chemical binding]; other site 347495006026 Na binding site 1 [ion binding]; other site 347495006027 putative substrate binding site 2 [chemical binding]; other site 347495006028 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495006029 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 347495006030 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 347495006031 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 347495006032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495006033 motif II; other site 347495006034 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 347495006035 fructuronate transporter; Provisional; Region: PRK10034; cl15264 347495006036 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 347495006037 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 347495006038 active site 347495006039 NAD binding site [chemical binding]; other site 347495006040 metal binding site [ion binding]; metal-binding site 347495006041 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 347495006042 aspartate racemase; Region: asp_race; TIGR00035 347495006043 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 347495006044 homodimer interaction site [polypeptide binding]; other site 347495006045 cofactor binding site; other site 347495006046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495006047 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006048 Coenzyme A binding pocket [chemical binding]; other site 347495006049 hypothetical protein; Validated; Region: PRK06769 347495006050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495006051 active site 347495006052 motif I; other site 347495006053 motif II; other site 347495006054 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 347495006055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006056 Coenzyme A binding pocket [chemical binding]; other site 347495006057 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 347495006058 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495006059 Walker A/P-loop; other site 347495006060 ATP binding site [chemical binding]; other site 347495006061 Q-loop/lid; other site 347495006062 ABC transporter signature motif; other site 347495006063 Walker B; other site 347495006064 D-loop; other site 347495006065 H-loop/switch region; other site 347495006066 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 347495006067 YpjP-like protein; Region: YpjP; pfam14005 347495006068 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 347495006069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495006070 motif II; other site 347495006071 hypothetical protein; Provisional; Region: PRK06724 347495006072 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495006073 active site 347495006074 metal binding site [ion binding]; metal-binding site 347495006075 Phosphotransferase enzyme family; Region: APH; pfam01636 347495006076 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 347495006077 active site 347495006078 ATP binding site [chemical binding]; other site 347495006079 substrate binding site [chemical binding]; other site 347495006080 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 347495006081 Active site serine [active] 347495006082 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495006083 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495006084 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 347495006085 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 347495006086 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 347495006087 thymidylate synthase; Region: thym_sym; TIGR03284 347495006088 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 347495006089 dimerization interface [polypeptide binding]; other site 347495006090 active site 347495006091 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 347495006092 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 347495006093 folate binding site [chemical binding]; other site 347495006094 NADP+ binding site [chemical binding]; other site 347495006095 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 347495006096 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495006097 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 347495006098 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495006099 azoreductase; Reviewed; Region: PRK00170 347495006100 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 347495006101 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 347495006102 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 347495006103 putative acyl-acceptor binding pocket; other site 347495006104 Haemolysin-III related; Region: HlyIII; cl03831 347495006105 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 347495006106 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 347495006107 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 347495006108 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 347495006109 EDD domain protein, DegV family; Region: DegV; TIGR00762 347495006110 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 347495006111 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 347495006112 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 347495006113 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 347495006114 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 347495006115 Cu(I) binding site [ion binding]; other site 347495006116 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 347495006117 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 347495006118 putative dimer interface [polypeptide binding]; other site 347495006119 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 347495006120 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 347495006121 active site 347495006122 dimer interface [polypeptide binding]; other site 347495006123 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 347495006124 Ligand Binding Site [chemical binding]; other site 347495006125 Molecular Tunnel; other site 347495006126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495006127 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 347495006128 active site 347495006129 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495006130 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 347495006131 siderophore binding site; other site 347495006132 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 347495006133 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 347495006134 homodimer interface [polypeptide binding]; other site 347495006135 substrate-cofactor binding pocket; other site 347495006136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495006137 catalytic residue [active] 347495006138 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 347495006139 FMN binding site [chemical binding]; other site 347495006140 dimer interface [polypeptide binding]; other site 347495006141 Isochorismatase family; Region: Isochorismatase; pfam00857 347495006142 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 347495006143 catalytic triad [active] 347495006144 conserved cis-peptide bond; other site 347495006145 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 347495006146 nudix motif; other site 347495006147 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 347495006148 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 347495006149 putative dimer interface [polypeptide binding]; other site 347495006150 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 347495006151 Mechanosensitive ion channel; Region: MS_channel; pfam00924 347495006152 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 347495006153 GAF domain; Region: GAF; pfam01590 347495006154 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495006155 Histidine kinase; Region: HisKA_3; pfam07730 347495006156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495006157 ATP binding site [chemical binding]; other site 347495006158 Mg2+ binding site [ion binding]; other site 347495006159 G-X-G motif; other site 347495006160 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495006161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495006162 active site 347495006163 phosphorylation site [posttranslational modification] 347495006164 intermolecular recognition site; other site 347495006165 dimerization interface [polypeptide binding]; other site 347495006166 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495006167 DNA binding residues [nucleotide binding] 347495006168 dimerization interface [polypeptide binding]; other site 347495006169 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 347495006170 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 347495006171 putative active site [active] 347495006172 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 347495006173 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 347495006174 NAD binding site [chemical binding]; other site 347495006175 substrate binding site [chemical binding]; other site 347495006176 catalytic Zn binding site [ion binding]; other site 347495006177 tetramer interface [polypeptide binding]; other site 347495006178 structural Zn binding site [ion binding]; other site 347495006179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 347495006180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495006181 dimer interface [polypeptide binding]; other site 347495006182 conserved gate region; other site 347495006183 ABC-ATPase subunit interface; other site 347495006184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495006185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495006186 dimer interface [polypeptide binding]; other site 347495006187 conserved gate region; other site 347495006188 putative PBP binding loops; other site 347495006189 ABC-ATPase subunit interface; other site 347495006190 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495006191 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495006192 Erythromycin esterase; Region: Erythro_esteras; pfam05139 347495006193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 347495006194 fructuronate transporter; Provisional; Region: PRK10034; cl15264 347495006195 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 347495006196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495006197 active site 347495006198 Predicted flavoprotein [General function prediction only]; Region: COG0431 347495006199 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 347495006200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006201 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495006202 putative substrate translocation pore; other site 347495006203 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 347495006204 Uncharacterized conserved protein [Function unknown]; Region: COG1434 347495006205 putative active site [active] 347495006206 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 347495006207 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 347495006208 Walker A/P-loop; other site 347495006209 ATP binding site [chemical binding]; other site 347495006210 Q-loop/lid; other site 347495006211 ABC transporter signature motif; other site 347495006212 Walker B; other site 347495006213 D-loop; other site 347495006214 H-loop/switch region; other site 347495006215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495006216 dimer interface [polypeptide binding]; other site 347495006217 conserved gate region; other site 347495006218 ABC-ATPase subunit interface; other site 347495006219 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 347495006220 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 347495006221 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 347495006222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 347495006223 Protein of unknown function (DUF524); Region: DUF524; pfam04411 347495006224 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 347495006225 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 347495006226 DNA binding residues [nucleotide binding] 347495006227 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 347495006228 Domain of unknown function DUF21; Region: DUF21; pfam01595 347495006229 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 347495006230 Transporter associated domain; Region: CorC_HlyC; smart01091 347495006231 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 347495006232 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 347495006233 NAD(P) binding site [chemical binding]; other site 347495006234 catalytic residues [active] 347495006235 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 347495006236 Histidine kinase N terminal; Region: HisK_N; pfam09385 347495006237 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495006238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495006239 dimer interface [polypeptide binding]; other site 347495006240 phosphorylation site [posttranslational modification] 347495006241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495006242 ATP binding site [chemical binding]; other site 347495006243 Mg2+ binding site [ion binding]; other site 347495006244 G-X-G motif; other site 347495006245 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 347495006246 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 347495006247 hypothetical protein; Provisional; Region: PRK06917 347495006248 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495006249 inhibitor-cofactor binding pocket; inhibition site 347495006250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495006251 catalytic residue [active] 347495006252 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 347495006253 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 347495006254 acetylornithine deacetylase; Validated; Region: PRK06915 347495006255 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 347495006256 metal binding site [ion binding]; metal-binding site 347495006257 dimer interface [polypeptide binding]; other site 347495006258 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 347495006259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495006260 PAS fold; Region: PAS_4; pfam08448 347495006261 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 347495006262 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495006263 Walker A motif; other site 347495006264 ATP binding site [chemical binding]; other site 347495006265 Walker B motif; other site 347495006266 arginine finger; other site 347495006267 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 347495006268 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 347495006269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495006270 FeS/SAM binding site; other site 347495006271 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 347495006272 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 347495006273 toxin interface [polypeptide binding]; other site 347495006274 Zn binding site [ion binding]; other site 347495006275 hypothetical protein; Provisional; Region: PRK13672 347495006276 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 347495006277 YozD-like protein; Region: YozD; pfam14162 347495006278 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 347495006279 Catalytic domain of Protein Kinases; Region: PKc; cd00180 347495006280 active site 347495006281 ATP binding site [chemical binding]; other site 347495006282 substrate binding site [chemical binding]; other site 347495006283 activation loop (A-loop); other site 347495006284 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 347495006285 SpoOM protein; Region: Spo0M; pfam07070 347495006286 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 347495006287 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 347495006288 active site 347495006289 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 347495006290 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 347495006291 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 347495006292 catalytic residues [active] 347495006293 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 347495006294 homotrimer interaction site [polypeptide binding]; other site 347495006295 putative active site [active] 347495006296 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 347495006297 CHRD domain; Region: CHRD; pfam07452 347495006298 C1q domain; Region: C1q; cl17543 347495006299 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 347495006300 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 347495006301 YolD-like protein; Region: YolD; pfam08863 347495006302 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 347495006303 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 347495006304 classical (c) SDRs; Region: SDR_c; cd05233 347495006305 NAD(P) binding site [chemical binding]; other site 347495006306 active site 347495006307 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 347495006308 Transglycosylase; Region: Transgly; pfam00912 347495006309 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 347495006310 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495006311 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495006313 putative substrate translocation pore; other site 347495006314 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 347495006315 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 347495006316 dimer interface [polypeptide binding]; other site 347495006317 Citrate synthase; Region: Citrate_synt; pfam00285 347495006318 active site 347495006319 coenzyme A binding site [chemical binding]; other site 347495006320 citrylCoA binding site [chemical binding]; other site 347495006321 oxalacetate/citrate binding site [chemical binding]; other site 347495006322 catalytic triad [active] 347495006323 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 347495006324 2-methylcitrate dehydratase; Region: prpD; TIGR02330 347495006325 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 347495006326 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 347495006327 tetramer interface [polypeptide binding]; other site 347495006328 active site 347495006329 Mg2+/Mn2+ binding site [ion binding]; other site 347495006330 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 347495006331 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 347495006332 active site 347495006333 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 347495006334 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 347495006335 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 347495006336 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 347495006337 tetrameric interface [polypeptide binding]; other site 347495006338 NAD binding site [chemical binding]; other site 347495006339 catalytic residues [active] 347495006340 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 347495006341 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 347495006342 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495006343 substrate binding site [chemical binding]; other site 347495006344 oxyanion hole (OAH) forming residues; other site 347495006345 trimer interface [polypeptide binding]; other site 347495006346 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 347495006347 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 347495006348 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 347495006349 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 347495006350 active site 347495006351 metal binding site [ion binding]; metal-binding site 347495006352 DNA binding site [nucleotide binding] 347495006353 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 347495006354 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 347495006355 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 347495006356 Walker A/P-loop; other site 347495006357 ATP binding site [chemical binding]; other site 347495006358 Q-loop/lid; other site 347495006359 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 347495006360 ABC transporter signature motif; other site 347495006361 Walker B; other site 347495006362 D-loop; other site 347495006363 H-loop/switch region; other site 347495006364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495006365 dimerization interface [polypeptide binding]; other site 347495006366 putative DNA binding site [nucleotide binding]; other site 347495006367 putative Zn2+ binding site [ion binding]; other site 347495006368 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 347495006369 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 347495006370 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006371 putative substrate translocation pore; other site 347495006372 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 347495006373 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 347495006374 putative NAD(P) binding site [chemical binding]; other site 347495006375 active site 347495006376 isochorismate synthase DhbC; Validated; Region: PRK06923 347495006377 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 347495006378 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 347495006379 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 347495006380 acyl-activating enzyme (AAE) consensus motif; other site 347495006381 active site 347495006382 AMP binding site [chemical binding]; other site 347495006383 substrate binding site [chemical binding]; other site 347495006384 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 347495006385 hydrophobic substrate binding pocket; other site 347495006386 Isochorismatase family; Region: Isochorismatase; pfam00857 347495006387 active site 347495006388 conserved cis-peptide bond; other site 347495006389 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 347495006390 Condensation domain; Region: Condensation; pfam00668 347495006391 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 347495006392 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 347495006393 acyl-activating enzyme (AAE) consensus motif; other site 347495006394 AMP binding site [chemical binding]; other site 347495006395 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 347495006396 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 347495006397 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 347495006398 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 347495006399 acyl-activating enzyme (AAE) consensus motif; other site 347495006400 AMP binding site [chemical binding]; other site 347495006401 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 347495006402 MbtH-like protein; Region: MbtH; cl01279 347495006403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495006405 putative substrate translocation pore; other site 347495006406 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 347495006407 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 347495006408 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 347495006409 IHF dimer interface [polypeptide binding]; other site 347495006410 IHF - DNA interface [nucleotide binding]; other site 347495006411 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 347495006412 DinB family; Region: DinB; cl17821 347495006413 DinB superfamily; Region: DinB_2; pfam12867 347495006414 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 347495006415 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 347495006416 active site 347495006417 catalytic triad [active] 347495006418 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495006419 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 347495006420 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 347495006421 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 347495006422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495006423 RNA binding surface [nucleotide binding]; other site 347495006424 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 347495006425 probable active site [active] 347495006426 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 347495006427 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 347495006428 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 347495006429 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 347495006430 active site 347495006431 dimer interface [polypeptide binding]; other site 347495006432 motif 1; other site 347495006433 motif 2; other site 347495006434 motif 3; other site 347495006435 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 347495006436 anticodon binding site; other site 347495006437 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 347495006438 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495006439 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495006440 Walker A/P-loop; other site 347495006441 ATP binding site [chemical binding]; other site 347495006442 Q-loop/lid; other site 347495006443 ABC transporter signature motif; other site 347495006444 Walker B; other site 347495006445 D-loop; other site 347495006446 H-loop/switch region; other site 347495006447 FtsX-like permease family; Region: FtsX; pfam02687 347495006448 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495006449 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495006450 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 347495006451 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495006452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006453 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495006454 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 347495006455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495006456 dimer interface [polypeptide binding]; other site 347495006457 conserved gate region; other site 347495006458 ABC-ATPase subunit interface; other site 347495006459 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 347495006460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006461 S-adenosylmethionine binding site [chemical binding]; other site 347495006462 Protein of unknown function (DUF2185); Region: DUF2185; pfam09951 347495006463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495006464 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 347495006465 active site 347495006466 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 347495006467 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 347495006468 multidrug resistance protein (mdr1); Provisional; Region: PTZ00265 347495006469 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 347495006470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495006471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495006472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495006473 MMPL family; Region: MMPL; pfam03176 347495006474 MMPL family; Region: MMPL; pfam03176 347495006475 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 347495006476 Chloramphenicol acetyltransferase; Region: CAT; cl02008 347495006477 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 347495006478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006479 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 347495006480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495006481 Coenzyme A binding pocket [chemical binding]; other site 347495006482 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495006483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495006485 Coenzyme A binding pocket [chemical binding]; other site 347495006486 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 347495006487 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 347495006488 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 347495006489 putative acetyltransferase YhhY; Provisional; Region: PRK10140 347495006490 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006491 Coenzyme A binding pocket [chemical binding]; other site 347495006492 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495006493 EamA-like transporter family; Region: EamA; pfam00892 347495006494 EamA-like transporter family; Region: EamA; pfam00892 347495006495 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 347495006496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495006497 non-specific DNA binding site [nucleotide binding]; other site 347495006498 salt bridge; other site 347495006499 sequence-specific DNA binding site [nucleotide binding]; other site 347495006500 Cupin domain; Region: Cupin_2; pfam07883 347495006501 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 347495006502 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 347495006503 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495006504 protoporphyrinogen oxidase; Provisional; Region: PRK12416 347495006505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495006506 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006507 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495006508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495006509 Cold-inducible protein YdjO; Region: YdjO; pfam14169 347495006510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 347495006511 DNA-binding site [nucleotide binding]; DNA binding site 347495006512 RNA-binding motif; other site 347495006513 CAAX protease self-immunity; Region: Abi; pfam02517 347495006514 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 347495006515 AAA domain; Region: AAA_18; pfam13238 347495006516 active site 347495006517 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 347495006518 active site 347495006519 metal binding site [ion binding]; metal-binding site 347495006520 hypothetical protein; Provisional; Region: PRK06770 347495006521 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495006522 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495006523 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495006524 dimerization interface [polypeptide binding]; other site 347495006525 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 347495006526 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 347495006527 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 347495006528 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 347495006529 active site 347495006530 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 347495006531 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 347495006532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495006533 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495006534 dimerization interface [polypeptide binding]; other site 347495006535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 347495006536 MOSC domain; Region: MOSC; pfam03473 347495006537 3-alpha domain; Region: 3-alpha; pfam03475 347495006538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006539 Coenzyme A binding pocket [chemical binding]; other site 347495006540 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 347495006541 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495006542 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495006543 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495006544 Walker A/P-loop; other site 347495006545 ATP binding site [chemical binding]; other site 347495006546 Q-loop/lid; other site 347495006547 ABC transporter signature motif; other site 347495006548 Walker B; other site 347495006549 D-loop; other site 347495006550 H-loop/switch region; other site 347495006551 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495006552 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495006553 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 347495006554 Walker A/P-loop; other site 347495006555 ATP binding site [chemical binding]; other site 347495006556 Q-loop/lid; other site 347495006557 ABC transporter signature motif; other site 347495006558 Walker B; other site 347495006559 D-loop; other site 347495006560 H-loop/switch region; other site 347495006561 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 347495006562 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 347495006563 active site 347495006564 metal binding site [ion binding]; metal-binding site 347495006565 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 347495006566 LysE type translocator; Region: LysE; cl00565 347495006567 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 347495006568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495006569 non-specific DNA binding site [nucleotide binding]; other site 347495006570 salt bridge; other site 347495006571 sequence-specific DNA binding site [nucleotide binding]; other site 347495006572 Cupin domain; Region: Cupin_2; pfam07883 347495006573 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 347495006574 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 347495006575 BclB C-terminal domain; Region: exospore_TM; TIGR03721 347495006576 Cupin; Region: Cupin_1; smart00835 347495006577 HD domain; Region: HD_4; pfam13328 347495006578 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 347495006579 metal binding triad [ion binding]; metal-binding site 347495006580 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 347495006581 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 347495006582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495006583 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 347495006584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495006585 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 347495006586 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495006587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006588 S-adenosylmethionine binding site [chemical binding]; other site 347495006589 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 347495006590 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 347495006591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 347495006592 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 347495006593 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 347495006594 active site 347495006595 P-loop; other site 347495006596 phosphorylation site [posttranslational modification] 347495006597 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 347495006598 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 347495006599 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 347495006600 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 347495006601 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 347495006602 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 347495006603 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 347495006604 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 347495006605 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495006606 catalytic residue [active] 347495006607 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 347495006608 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 347495006609 tetramer interface [polypeptide binding]; other site 347495006610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495006611 catalytic residue [active] 347495006612 Uncharacterized conserved protein [Function unknown]; Region: COG3339 347495006613 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495006614 Proteins of 100 residues with WXG; Region: WXG100; cl02005 347495006615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495006616 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 347495006617 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 347495006618 ATP binding site [chemical binding]; other site 347495006619 Mg++ binding site [ion binding]; other site 347495006620 motif III; other site 347495006621 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495006622 nucleotide binding region [chemical binding]; other site 347495006623 ATP-binding site [chemical binding]; other site 347495006624 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495006625 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495006626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006627 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495006628 putative substrate translocation pore; other site 347495006629 FtsX-like permease family; Region: FtsX; pfam02687 347495006630 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495006631 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495006632 Walker A/P-loop; other site 347495006633 ATP binding site [chemical binding]; other site 347495006634 Q-loop/lid; other site 347495006635 ABC transporter signature motif; other site 347495006636 Walker B; other site 347495006637 D-loop; other site 347495006638 H-loop/switch region; other site 347495006639 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495006640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006641 S-adenosylmethionine binding site [chemical binding]; other site 347495006642 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 347495006643 dimer interface [polypeptide binding]; other site 347495006644 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 347495006645 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 347495006646 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 347495006647 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 347495006648 Int/Topo IB signature motif; other site 347495006649 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 347495006650 potential frameshift: common BLAST hit: gi|217961387|ref|YP_002339955.1| MazG nucleotide pyrophosphohydrolase domain family protein 347495006651 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 347495006652 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 347495006653 C1q domain; Region: C1q; cl17543 347495006654 Protein of unknown function (DUF3983); Region: DUF3983; pfam13137 347495006655 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 347495006656 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 347495006657 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 347495006658 Cytochrome P450; Region: p450; cl12078 347495006659 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 347495006660 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 347495006661 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 347495006662 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495006663 MarR family; Region: MarR_2; pfam12802 347495006664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495006665 catalytic core [active] 347495006666 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 347495006667 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 347495006668 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 347495006669 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 347495006670 metal binding site [ion binding]; metal-binding site 347495006671 dimer interface [polypeptide binding]; other site 347495006672 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 347495006673 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 347495006674 trimer interface [polypeptide binding]; other site 347495006675 active site 347495006676 substrate binding site [chemical binding]; other site 347495006677 CoA binding site [chemical binding]; other site 347495006678 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 347495006679 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495006680 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 347495006681 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 347495006682 active site 347495006683 catalytic triad [active] 347495006684 oxyanion hole [active] 347495006685 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 347495006686 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495006687 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 347495006688 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495006689 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 347495006690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495006691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495006692 DNA binding residues [nucleotide binding] 347495006693 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 347495006694 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495006695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495006696 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 347495006697 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495006698 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495006699 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495006700 beta-lactamase TEM; Provisional; Region: PRK15442 347495006701 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 347495006702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495006703 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495006704 DNA binding site [nucleotide binding] 347495006705 domain linker motif; other site 347495006706 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 347495006707 dimerization interface [polypeptide binding]; other site 347495006708 ligand binding site [chemical binding]; other site 347495006709 polyol permease family; Region: 2A0118; TIGR00897 347495006710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006711 putative substrate translocation pore; other site 347495006712 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 347495006713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 347495006714 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 347495006715 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 347495006716 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 347495006717 substrate binding site [chemical binding]; other site 347495006718 ATP binding site [chemical binding]; other site 347495006719 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 347495006720 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 347495006721 tetrameric interface [polypeptide binding]; other site 347495006722 NAD binding site [chemical binding]; other site 347495006723 catalytic residues [active] 347495006724 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 347495006725 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 347495006726 PYR/PP interface [polypeptide binding]; other site 347495006727 dimer interface [polypeptide binding]; other site 347495006728 TPP binding site [chemical binding]; other site 347495006729 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 347495006730 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 347495006731 TPP-binding site; other site 347495006732 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 347495006733 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 347495006734 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 347495006735 intersubunit interface [polypeptide binding]; other site 347495006736 active site 347495006737 zinc binding site [ion binding]; other site 347495006738 Na+ binding site [ion binding]; other site 347495006739 KduI/IolB family; Region: KduI; pfam04962 347495006740 DinB superfamily; Region: DinB_2; pfam12867 347495006741 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 347495006742 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 347495006743 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 347495006744 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 347495006745 active site 347495006746 metal binding site [ion binding]; metal-binding site 347495006747 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 347495006748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495006749 TPR motif; other site 347495006750 binding surface 347495006751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495006752 non-specific DNA binding site [nucleotide binding]; other site 347495006753 salt bridge; other site 347495006754 sequence-specific DNA binding site [nucleotide binding]; other site 347495006755 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 347495006756 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 347495006757 S-layer homology domain; Region: SLH; pfam00395 347495006758 S-layer homology domain; Region: SLH; pfam00395 347495006759 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 347495006760 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 347495006761 active site 347495006762 metal binding site [ion binding]; metal-binding site 347495006763 potential frameshift: common BLAST hit: gi|225864510|ref|YP_002749888.1| hemolysin II 347495006764 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 347495006765 Leukocidin/Hemolysin toxin family; Region: Leukocidin; cl08468 347495006766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495006767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495006768 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495006769 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495006770 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495006771 PAS fold; Region: PAS_4; pfam08448 347495006772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495006773 putative active site [active] 347495006774 heme pocket [chemical binding]; other site 347495006775 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495006776 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495006777 metal binding site [ion binding]; metal-binding site 347495006778 active site 347495006779 I-site; other site 347495006780 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495006781 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495006782 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495006783 Tar ligand binding domain homologue; Region: TarH; pfam02203 347495006784 Cache domain; Region: Cache_1; pfam02743 347495006785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495006786 dimerization interface [polypeptide binding]; other site 347495006787 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495006788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495006789 dimer interface [polypeptide binding]; other site 347495006790 putative CheW interface [polypeptide binding]; other site 347495006791 Homeodomain-like domain; Region: HTH_23; cl17451 347495006792 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 347495006793 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495006794 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 347495006795 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495006796 active site residue [active] 347495006797 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495006798 active site residue [active] 347495006799 Protein of unknown function (DUF523); Region: DUF523; pfam04463 347495006800 Uncharacterized conserved protein [Function unknown]; Region: COG3272 347495006801 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 347495006802 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 347495006803 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 347495006804 FAD binding site [chemical binding]; other site 347495006805 homotetramer interface [polypeptide binding]; other site 347495006806 substrate binding pocket [chemical binding]; other site 347495006807 catalytic base [active] 347495006808 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 347495006809 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 347495006810 ATP-grasp domain; Region: ATP-grasp_4; cl17255 347495006811 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 347495006812 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 347495006813 carboxyltransferase (CT) interaction site; other site 347495006814 biotinylation site [posttranslational modification]; other site 347495006815 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 347495006816 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 347495006817 active site 347495006818 catalytic residues [active] 347495006819 metal binding site [ion binding]; metal-binding site 347495006820 enoyl-CoA hydratase; Provisional; Region: PRK07657 347495006821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495006822 substrate binding site [chemical binding]; other site 347495006823 oxyanion hole (OAH) forming residues; other site 347495006824 trimer interface [polypeptide binding]; other site 347495006825 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 347495006826 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 347495006827 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 347495006828 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 347495006829 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 347495006830 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 347495006831 acyl-activating enzyme (AAE) consensus motif; other site 347495006832 putative AMP binding site [chemical binding]; other site 347495006833 putative active site [active] 347495006834 putative CoA binding site [chemical binding]; other site 347495006835 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495006836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006837 Coenzyme A binding pocket [chemical binding]; other site 347495006838 hypothetical protein; Provisional; Region: PRK08233 347495006839 AAA domain; Region: AAA_18; pfam13238 347495006840 active site 347495006841 DinB family; Region: DinB; cl17821 347495006842 DinB superfamily; Region: DinB_2; pfam12867 347495006843 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 347495006844 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495006845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495006846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495006847 dimer interface [polypeptide binding]; other site 347495006848 phosphorylation site [posttranslational modification] 347495006849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495006850 ATP binding site [chemical binding]; other site 347495006851 Mg2+ binding site [ion binding]; other site 347495006852 G-X-G motif; other site 347495006853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495006854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495006855 active site 347495006856 phosphorylation site [posttranslational modification] 347495006857 intermolecular recognition site; other site 347495006858 dimerization interface [polypeptide binding]; other site 347495006859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495006860 DNA binding site [nucleotide binding] 347495006861 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 347495006862 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 347495006863 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 347495006864 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 347495006865 NADH(P)-binding; Region: NAD_binding_10; pfam13460 347495006866 NAD binding site [chemical binding]; other site 347495006867 substrate binding site [chemical binding]; other site 347495006868 putative active site [active] 347495006869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006870 Coenzyme A binding pocket [chemical binding]; other site 347495006871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495006872 Coenzyme A binding pocket [chemical binding]; other site 347495006873 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 347495006874 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495006875 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 347495006876 active site 347495006877 Zn binding site [ion binding]; other site 347495006878 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 347495006879 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 347495006880 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 347495006881 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 347495006882 putative hydrophobic ligand binding site [chemical binding]; other site 347495006883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495006884 AAA domain; Region: AAA_21; pfam13304 347495006885 Walker A/P-loop; other site 347495006886 ATP binding site [chemical binding]; other site 347495006887 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495006888 ABC transporter signature motif; other site 347495006889 Walker B; other site 347495006890 D-loop; other site 347495006891 H-loop/switch region; other site 347495006892 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 347495006893 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 347495006894 Restriction endonuclease XhoI; Region: XhoI; pfam04555 347495006895 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 347495006896 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495006897 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495006898 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495006899 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495006900 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 347495006901 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495006902 DNA binding residues [nucleotide binding] 347495006903 drug binding residues [chemical binding]; other site 347495006904 dimer interface [polypeptide binding]; other site 347495006905 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 347495006906 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495006907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495006908 putative substrate translocation pore; other site 347495006909 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 347495006910 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 347495006911 active site 347495006912 ATP binding site [chemical binding]; other site 347495006913 substrate binding site [chemical binding]; other site 347495006914 activation loop (A-loop); other site 347495006915 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495006916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006917 S-adenosylmethionine binding site [chemical binding]; other site 347495006918 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 347495006919 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495006920 Phosphotransferase enzyme family; Region: APH; pfam01636 347495006921 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 347495006922 active site 347495006923 substrate binding site [chemical binding]; other site 347495006924 ATP binding site [chemical binding]; other site 347495006925 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495006926 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 347495006927 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 347495006928 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 347495006929 active site 347495006930 Zn binding site [ion binding]; other site 347495006931 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 347495006932 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495006933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495006934 DNA-binding site [nucleotide binding]; DNA binding site 347495006935 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495006936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495006937 homodimer interface [polypeptide binding]; other site 347495006938 catalytic residue [active] 347495006939 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 347495006940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006941 S-adenosylmethionine binding site [chemical binding]; other site 347495006942 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495006943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495006944 S-adenosylmethionine binding site [chemical binding]; other site 347495006945 potential frameshift: common BLAST hit: gi|49477782|ref|YP_036699.1| regucalcin-like protein 347495006946 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 347495006947 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 347495006948 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 347495006949 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 347495006950 active site 347495006951 HIGH motif; other site 347495006952 KMSKS motif; other site 347495006953 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 347495006954 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 347495006955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495006956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495006957 active site 347495006958 phosphorylation site [posttranslational modification] 347495006959 intermolecular recognition site; other site 347495006960 dimerization interface [polypeptide binding]; other site 347495006961 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495006962 DNA binding site [nucleotide binding] 347495006963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495006964 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 347495006965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495006966 ATP binding site [chemical binding]; other site 347495006967 Mg2+ binding site [ion binding]; other site 347495006968 G-X-G motif; other site 347495006969 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 347495006970 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495006971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495006972 ABC transporter; Region: ABC_tran_2; pfam12848 347495006973 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495006974 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495006975 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495006976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495006977 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 347495006978 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495006979 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495006980 Walker A/P-loop; other site 347495006981 ATP binding site [chemical binding]; other site 347495006982 Q-loop/lid; other site 347495006983 ABC transporter signature motif; other site 347495006984 Walker B; other site 347495006985 D-loop; other site 347495006986 H-loop/switch region; other site 347495006987 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495006988 FtsX-like permease family; Region: FtsX; pfam02687 347495006989 hypothetical protein; Provisional; Region: PRK06760 347495006990 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 347495006991 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 347495006992 homoserine dehydrogenase; Validated; Region: PRK06813 347495006993 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 347495006994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495006995 DNA-binding site [nucleotide binding]; DNA binding site 347495006996 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 347495006997 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 347495006998 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 347495006999 active site 347495007000 catalytic site [active] 347495007001 metal binding site [ion binding]; metal-binding site 347495007002 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495007003 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495007004 DNA-binding site [nucleotide binding]; DNA binding site 347495007005 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495007006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495007007 homodimer interface [polypeptide binding]; other site 347495007008 catalytic residue [active] 347495007009 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495007010 EamA-like transporter family; Region: EamA; pfam00892 347495007011 EamA-like transporter family; Region: EamA; pfam00892 347495007012 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007013 Coenzyme A binding pocket [chemical binding]; other site 347495007014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 347495007015 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 347495007016 nudix motif; other site 347495007017 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 347495007018 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 347495007019 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495007020 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495007021 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 347495007022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007023 putative substrate translocation pore; other site 347495007024 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 347495007025 nudix motif; other site 347495007026 DNA polymerase III subunit beta; Validated; Region: PRK06673 347495007027 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 347495007028 putative DNA binding surface [nucleotide binding]; other site 347495007029 dimer interface [polypeptide binding]; other site 347495007030 beta-clamp/clamp loader binding surface; other site 347495007031 beta-clamp/translesion DNA polymerase binding surface; other site 347495007032 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 347495007033 putative active site [active] 347495007034 nucleotide binding site [chemical binding]; other site 347495007035 nudix motif; other site 347495007036 putative metal binding site [ion binding]; other site 347495007037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495007038 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 347495007039 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 347495007040 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 347495007041 homotrimer interaction site [polypeptide binding]; other site 347495007042 putative active site [active] 347495007043 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 347495007044 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 347495007045 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 347495007046 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 347495007047 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 347495007048 YxiJ-like protein; Region: YxiJ; pfam14176 347495007049 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 347495007050 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 347495007051 active site 347495007052 nucleophile elbow; other site 347495007053 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 347495007054 pentamer interface [polypeptide binding]; other site 347495007055 dodecaamer interface [polypeptide binding]; other site 347495007056 metal-dependent hydrolase; Provisional; Region: PRK13291 347495007057 DinB superfamily; Region: DinB_2; pfam12867 347495007058 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007059 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007060 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 347495007061 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 347495007062 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 347495007063 GIY-YIG motif/motif A; other site 347495007064 active site 347495007065 catalytic site [active] 347495007066 putative DNA binding site [nucleotide binding]; other site 347495007067 metal binding site [ion binding]; metal-binding site 347495007068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007069 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007070 Coenzyme A binding pocket [chemical binding]; other site 347495007071 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 347495007072 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 347495007073 active site 347495007074 ATP binding site [chemical binding]; other site 347495007075 substrate binding site [chemical binding]; other site 347495007076 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 347495007077 nudix motif; other site 347495007078 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 347495007079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495007080 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 347495007081 N-acetyltransferase; Region: Acetyltransf_2; cl00949 347495007082 MepB protein; Region: MepB; pfam08877 347495007083 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 347495007084 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 347495007085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495007086 motif II; other site 347495007087 DinB superfamily; Region: DinB_2; pfam12867 347495007088 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 347495007089 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 347495007090 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 347495007091 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 347495007092 active site 347495007093 pullulanase, type I; Region: pulA_typeI; TIGR02104 347495007094 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 347495007095 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 347495007096 Ca binding site [ion binding]; other site 347495007097 active site 347495007098 catalytic site [active] 347495007099 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 347495007100 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 347495007101 carbohydrate binding site [chemical binding]; other site 347495007102 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 347495007103 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495007104 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 347495007105 active site 347495007106 Zn binding site [ion binding]; other site 347495007107 Putative zinc-finger; Region: zf-HC2; pfam13490 347495007108 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 347495007109 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 347495007110 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495007111 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495007112 DNA binding residues [nucleotide binding] 347495007113 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 347495007114 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495007115 active site 347495007116 metal binding site [ion binding]; metal-binding site 347495007117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495007118 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 347495007119 SecY translocase; Region: SecY; pfam00344 347495007120 hypothetical protein; Validated; Region: PRK06672 347495007121 DnaA N-terminal domain; Region: DnaA_N; pfam11638 347495007122 DnaA N-terminal domain; Region: DnaA_N; pfam11638 347495007123 DnaA N-terminal domain; Region: DnaA_N; pfam11638 347495007124 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 347495007125 EamA-like transporter family; Region: EamA; pfam00892 347495007126 EamA-like transporter family; Region: EamA; pfam00892 347495007127 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495007128 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495007129 DNA-binding site [nucleotide binding]; DNA binding site 347495007130 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495007131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495007132 homodimer interface [polypeptide binding]; other site 347495007133 catalytic residue [active] 347495007134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495007135 TAP-like protein; Region: Abhydrolase_4; pfam08386 347495007136 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 347495007137 Mg binding site [ion binding]; other site 347495007138 nucleotide binding site [chemical binding]; other site 347495007139 putative protofilament interface [polypeptide binding]; other site 347495007140 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 347495007141 Predicted membrane protein [Function unknown]; Region: COG4129 347495007142 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 347495007143 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007144 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 347495007145 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 347495007146 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 347495007147 germination protein YpeB; Region: spore_YpeB; TIGR02889 347495007148 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 347495007149 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 347495007150 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 347495007151 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 347495007152 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495007153 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495007154 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 347495007155 arylformamidase; Region: trp_arylform; TIGR03035 347495007156 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 347495007157 kynureninase; Region: kynureninase; TIGR01814 347495007158 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495007159 catalytic residue [active] 347495007160 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495007161 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495007162 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 347495007163 nudix motif; other site 347495007164 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 347495007165 hydrophobic ligand binding site; other site 347495007166 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 347495007167 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 347495007168 GAF domain; Region: GAF; pfam01590 347495007169 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495007170 Walker A motif; other site 347495007171 ATP binding site [chemical binding]; other site 347495007172 Walker B motif; other site 347495007173 arginine finger; other site 347495007174 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 347495007175 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 347495007176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 347495007177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007178 Coenzyme A binding pocket [chemical binding]; other site 347495007179 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 347495007180 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 347495007181 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 347495007182 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495007183 S-adenosylmethionine binding site [chemical binding]; other site 347495007184 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 347495007185 Rrf2 family protein; Region: rrf2_super; TIGR00738 347495007186 Transcriptional regulator; Region: Rrf2; pfam02082 347495007187 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 347495007188 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 347495007189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495007190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495007191 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 347495007192 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 347495007193 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 347495007194 E3 interaction surface; other site 347495007195 lipoyl attachment site [posttranslational modification]; other site 347495007196 e3 binding domain; Region: E3_binding; pfam02817 347495007197 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 347495007198 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 347495007199 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 347495007200 alpha subunit interface [polypeptide binding]; other site 347495007201 TPP binding site [chemical binding]; other site 347495007202 heterodimer interface [polypeptide binding]; other site 347495007203 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495007204 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 347495007205 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 347495007206 tetramer interface [polypeptide binding]; other site 347495007207 TPP-binding site [chemical binding]; other site 347495007208 heterodimer interface [polypeptide binding]; other site 347495007209 phosphorylation loop region [posttranslational modification] 347495007210 DinB superfamily; Region: DinB_2; pfam12867 347495007211 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 347495007212 short chain dehydrogenase; Provisional; Region: PRK06914 347495007213 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 347495007214 NADP binding site [chemical binding]; other site 347495007215 active site 347495007216 steroid binding site; other site 347495007217 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 347495007218 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 347495007219 AAA domain; Region: AAA_18; pfam13238 347495007220 active site 347495007221 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 347495007222 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 347495007223 nudix motif; other site 347495007224 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 347495007225 Protein phosphatase 2C; Region: PP2C_2; pfam13672 347495007226 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 347495007227 nucleotide binding site/active site [active] 347495007228 HIT family signature motif; other site 347495007229 catalytic residue [active] 347495007230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495007231 dimer interface [polypeptide binding]; other site 347495007232 conserved gate region; other site 347495007233 putative PBP binding loops; other site 347495007234 ABC-ATPase subunit interface; other site 347495007235 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 347495007236 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 347495007237 Walker A/P-loop; other site 347495007238 ATP binding site [chemical binding]; other site 347495007239 Q-loop/lid; other site 347495007240 ABC transporter signature motif; other site 347495007241 Walker B; other site 347495007242 D-loop; other site 347495007243 H-loop/switch region; other site 347495007244 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 347495007245 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 347495007246 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 347495007247 Clp protease; Region: CLP_protease; pfam00574 347495007248 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 347495007249 oligomer interface [polypeptide binding]; other site 347495007250 active site residues [active] 347495007251 RNA polymerase factor sigma-70; Validated; Region: PRK06704 347495007252 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495007253 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 347495007254 DNA binding residues [nucleotide binding] 347495007255 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 347495007256 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 347495007257 catalytic loop [active] 347495007258 iron binding site [ion binding]; other site 347495007259 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 347495007260 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495007261 active site 347495007262 dimer interface [polypeptide binding]; other site 347495007263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007264 Coenzyme A binding pocket [chemical binding]; other site 347495007265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 347495007266 Chitin binding domain; Region: Chitin_bind_3; pfam03067 347495007267 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 347495007268 Interdomain contacts; other site 347495007269 Cytokine receptor motif; other site 347495007270 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 347495007271 Interdomain contacts; other site 347495007272 Cytokine receptor motif; other site 347495007273 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 347495007274 topology modulation protein; Reviewed; Region: PRK08118 347495007275 AAA domain; Region: AAA_17; pfam13207 347495007276 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 347495007277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495007278 S-adenosylmethionine binding site [chemical binding]; other site 347495007279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 347495007280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007281 Coenzyme A binding pocket [chemical binding]; other site 347495007282 S-layer homology domain; Region: SLH; pfam00395 347495007283 S-layer homology domain; Region: SLH; pfam00395 347495007284 S-layer homology domain; Region: SLH; pfam00395 347495007285 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 347495007286 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495007287 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 347495007288 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 347495007289 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 347495007290 active site 347495007291 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 347495007292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007293 Coenzyme A binding pocket [chemical binding]; other site 347495007294 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 347495007295 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 347495007296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007297 Coenzyme A binding pocket [chemical binding]; other site 347495007298 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495007299 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495007300 Protein of unknown function (DUF952); Region: DUF952; pfam06108 347495007301 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 347495007302 Part of AAA domain; Region: AAA_19; pfam13245 347495007303 Family description; Region: UvrD_C_2; pfam13538 347495007304 Predicted protease of the Abi (CAAX) family [General function prediction only]; Region: COG4449 347495007305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495007306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495007307 S-adenosylmethionine binding site [chemical binding]; other site 347495007308 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 347495007309 putative active site pocket [active] 347495007310 dimerization interface [polypeptide binding]; other site 347495007311 putative catalytic residue [active] 347495007312 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 347495007313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495007314 ATP binding site [chemical binding]; other site 347495007315 putative Mg++ binding site [ion binding]; other site 347495007316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495007317 nucleotide binding region [chemical binding]; other site 347495007318 ATP-binding site [chemical binding]; other site 347495007319 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 347495007320 HRDC domain; Region: HRDC; pfam00570 347495007321 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 347495007322 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 347495007323 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 347495007324 active site 347495007325 Zn binding site [ion binding]; other site 347495007326 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 347495007327 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 347495007328 DHHA2 domain; Region: DHHA2; pfam02833 347495007329 Chitin binding domain; Region: Chitin_bind_3; pfam03067 347495007330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495007331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007332 Coenzyme A binding pocket [chemical binding]; other site 347495007333 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 347495007334 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495007335 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 347495007336 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 347495007337 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 347495007338 NAD(P) binding site [chemical binding]; other site 347495007339 catalytic residues [active] 347495007340 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 347495007341 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 347495007342 inhibitor site; inhibition site 347495007343 active site 347495007344 dimer interface [polypeptide binding]; other site 347495007345 catalytic residue [active] 347495007346 Proline racemase; Region: Pro_racemase; pfam05544 347495007347 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 347495007348 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 347495007349 Proline racemase; Region: Pro_racemase; pfam05544 347495007350 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 347495007351 hydroxyglutarate oxidase; Provisional; Region: PRK11728 347495007352 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 347495007353 PAS domain; Region: PAS_10; pfam13596 347495007354 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 347495007355 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495007356 Walker A motif; other site 347495007357 ATP binding site [chemical binding]; other site 347495007358 Walker B motif; other site 347495007359 arginine finger; other site 347495007360 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 347495007361 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 347495007362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495007363 Walker A/P-loop; other site 347495007364 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 347495007365 catalytic loop [active] 347495007366 iron binding site [ion binding]; other site 347495007367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 347495007368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495007369 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 347495007370 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 347495007371 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 347495007372 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495007373 DinB superfamily; Region: DinB_2; pfam12867 347495007374 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 347495007375 DltD N-terminal region; Region: DltD_N; pfam04915 347495007376 DltD central region; Region: DltD_M; pfam04918 347495007377 DltD C-terminal region; Region: DltD_C; pfam04914 347495007378 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007380 Coenzyme A binding pocket [chemical binding]; other site 347495007381 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495007382 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495007383 peptide binding site [polypeptide binding]; other site 347495007384 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 347495007385 NlpC/P60 family; Region: NLPC_P60; pfam00877 347495007386 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 347495007387 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 347495007388 active site 347495007389 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 347495007390 Septum formation initiator; Region: DivIC; pfam04977 347495007391 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 347495007392 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 347495007393 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 347495007394 active site 347495007395 catalytic motif [active] 347495007396 Zn binding site [ion binding]; other site 347495007397 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495007398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495007399 S-adenosylmethionine binding site [chemical binding]; other site 347495007400 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 347495007401 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 347495007402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495007403 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495007404 dimerization interface [polypeptide binding]; other site 347495007405 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495007406 dimer interface [polypeptide binding]; other site 347495007407 phosphorylation site [posttranslational modification] 347495007408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495007409 ATP binding site [chemical binding]; other site 347495007410 Mg2+ binding site [ion binding]; other site 347495007411 G-X-G motif; other site 347495007412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495007413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495007414 active site 347495007415 phosphorylation site [posttranslational modification] 347495007416 intermolecular recognition site; other site 347495007417 dimerization interface [polypeptide binding]; other site 347495007418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495007419 DNA binding site [nucleotide binding] 347495007420 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 347495007421 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 347495007422 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 347495007423 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495007424 motif II; other site 347495007425 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 347495007426 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 347495007427 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 347495007428 Zn binding site [ion binding]; other site 347495007429 Spore germination protein; Region: Spore_permease; cl17796 347495007430 putative transporter; Provisional; Region: PRK11021 347495007431 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 347495007432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495007433 putative DNA binding site [nucleotide binding]; other site 347495007434 putative Zn2+ binding site [ion binding]; other site 347495007435 AsnC family; Region: AsnC_trans_reg; pfam01037 347495007436 EDD domain protein, DegV family; Region: DegV; TIGR00762 347495007437 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 347495007438 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 347495007439 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 347495007440 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 347495007441 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007442 Coenzyme A binding pocket [chemical binding]; other site 347495007443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495007445 putative substrate translocation pore; other site 347495007446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007447 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 347495007448 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 347495007449 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 347495007450 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 347495007451 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 347495007452 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 347495007453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495007455 putative substrate translocation pore; other site 347495007456 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 347495007457 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 347495007458 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 347495007459 active site 347495007460 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 347495007461 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495007462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495007463 S-adenosylmethionine binding site [chemical binding]; other site 347495007464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007465 putative substrate translocation pore; other site 347495007466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495007467 aspartate aminotransferase; Provisional; Region: PRK07681 347495007468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495007469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495007470 homodimer interface [polypeptide binding]; other site 347495007471 catalytic residue [active] 347495007472 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 347495007473 pantothenate kinase; Provisional; Region: PRK13317 347495007474 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 347495007475 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 347495007476 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 347495007477 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 347495007478 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495007479 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495007480 Walker A/P-loop; other site 347495007481 ATP binding site [chemical binding]; other site 347495007482 Q-loop/lid; other site 347495007483 ABC transporter signature motif; other site 347495007484 Walker B; other site 347495007485 D-loop; other site 347495007486 H-loop/switch region; other site 347495007487 Predicted transcriptional regulators [Transcription]; Region: COG1725 347495007488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495007489 DNA-binding site [nucleotide binding]; DNA binding site 347495007490 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 347495007491 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 347495007492 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 347495007493 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 347495007494 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 347495007495 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 347495007496 Domain of unknown function DUF20; Region: UPF0118; pfam01594 347495007497 HNH endonuclease; Region: HNH_5; pfam14279 347495007498 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 347495007499 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 347495007500 active site 347495007501 dimer interface [polypeptide binding]; other site 347495007502 non-prolyl cis peptide bond; other site 347495007503 insertion regions; other site 347495007504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 347495007505 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 347495007506 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 347495007507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495007508 substrate binding pocket [chemical binding]; other site 347495007509 membrane-bound complex binding site; other site 347495007510 hinge residues; other site 347495007511 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 347495007512 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 347495007513 Walker A/P-loop; other site 347495007514 ATP binding site [chemical binding]; other site 347495007515 Q-loop/lid; other site 347495007516 ABC transporter signature motif; other site 347495007517 Walker B; other site 347495007518 D-loop; other site 347495007519 H-loop/switch region; other site 347495007520 Protein of unknown function (DUF402); Region: DUF402; pfam04167 347495007521 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 347495007522 nudix motif; other site 347495007523 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495007524 binding surface 347495007525 TPR motif; other site 347495007526 hypothetical protein; Provisional; Region: PRK09620 347495007527 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 347495007528 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 347495007529 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 347495007530 Coenzyme A binding pocket [chemical binding]; other site 347495007531 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 347495007532 DinB superfamily; Region: DinB_2; pfam12867 347495007533 Protein of unknown function (DUF664); Region: DUF664; pfam04978 347495007534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 347495007535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007536 Coenzyme A binding pocket [chemical binding]; other site 347495007537 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007538 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007539 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 347495007540 active site 347495007541 NTP binding site [chemical binding]; other site 347495007542 metal binding triad [ion binding]; metal-binding site 347495007543 antibiotic binding site [chemical binding]; other site 347495007544 A new structural DNA glycosylase; Region: AlkD_like; cd06561 347495007545 active site 347495007546 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 347495007547 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 347495007548 NodB motif; other site 347495007549 active site 347495007550 catalytic site [active] 347495007551 Zn binding site [ion binding]; other site 347495007552 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 347495007553 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 347495007554 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 347495007555 Sulfatase; Region: Sulfatase; pfam00884 347495007556 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 347495007557 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495007558 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495007559 ABC transporter; Region: ABC_tran_2; pfam12848 347495007560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495007561 hypothetical protein; Provisional; Region: PRK06761 347495007562 MMPL family; Region: MMPL; pfam03176 347495007563 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 347495007564 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 347495007565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495007566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495007567 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 347495007568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007569 Coenzyme A binding pocket [chemical binding]; other site 347495007570 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 347495007571 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 347495007572 hinge; other site 347495007573 active site 347495007574 prephenate dehydrogenase; Validated; Region: PRK06545 347495007575 prephenate dehydrogenase; Validated; Region: PRK08507 347495007576 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 347495007577 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 347495007578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495007579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495007580 homodimer interface [polypeptide binding]; other site 347495007581 catalytic residue [active] 347495007582 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 347495007583 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 347495007584 Tetramer interface [polypeptide binding]; other site 347495007585 active site 347495007586 FMN-binding site [chemical binding]; other site 347495007587 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 347495007588 Chorismate mutase type II; Region: CM_2; cl00693 347495007589 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 347495007590 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 347495007591 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 347495007592 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 347495007593 Isochorismatase family; Region: Isochorismatase; pfam00857 347495007594 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 347495007595 catalytic triad [active] 347495007596 conserved cis-peptide bond; other site 347495007597 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007599 Coenzyme A binding pocket [chemical binding]; other site 347495007600 YfzA-like protein; Region: YfzA; pfam14118 347495007601 hypothetical protein; Provisional; Region: PRK06762 347495007602 AAA domain; Region: AAA_33; pfam13671 347495007603 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495007604 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495007605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 347495007606 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007607 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007608 Coenzyme A binding pocket [chemical binding]; other site 347495007609 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 347495007610 enoyl-CoA hydratase; Provisional; Region: PRK06688 347495007611 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495007612 substrate binding site [chemical binding]; other site 347495007613 oxyanion hole (OAH) forming residues; other site 347495007614 trimer interface [polypeptide binding]; other site 347495007615 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 347495007616 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495007617 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 347495007618 putative AMP binding site [chemical binding]; other site 347495007619 putative active site [active] 347495007620 acyl-activating enzyme (AAE) consensus motif; other site 347495007621 putative CoA binding site [chemical binding]; other site 347495007622 PAS domain; Region: PAS; smart00091 347495007623 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 347495007624 putative active site [active] 347495007625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495007626 Walker A motif; other site 347495007627 ATP binding site [chemical binding]; other site 347495007628 Walker B motif; other site 347495007629 arginine finger; other site 347495007630 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 347495007631 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 347495007632 malate:quinone oxidoreductase; Validated; Region: PRK05257 347495007633 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 347495007634 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 347495007635 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 347495007636 ligand binding site [chemical binding]; other site 347495007637 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 347495007638 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 347495007639 TM-ABC transporter signature motif; other site 347495007640 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 347495007641 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 347495007642 TM-ABC transporter signature motif; other site 347495007643 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 347495007644 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 347495007645 Walker A/P-loop; other site 347495007646 ATP binding site [chemical binding]; other site 347495007647 Q-loop/lid; other site 347495007648 ABC transporter signature motif; other site 347495007649 Walker B; other site 347495007650 D-loop; other site 347495007651 H-loop/switch region; other site 347495007652 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 347495007653 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 347495007654 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 347495007655 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 347495007656 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 347495007657 putative N- and C-terminal domain interface [polypeptide binding]; other site 347495007658 putative active site [active] 347495007659 putative MgATP binding site [chemical binding]; other site 347495007660 catalytic site [active] 347495007661 metal binding site [ion binding]; metal-binding site 347495007662 putative carbohydrate binding site [chemical binding]; other site 347495007663 Cupin domain; Region: Cupin_2; pfam07883 347495007664 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 347495007665 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 347495007666 putative active site; other site 347495007667 catalytic residue [active] 347495007668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007669 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495007670 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 347495007671 active site 347495007672 NTP binding site [chemical binding]; other site 347495007673 metal binding triad [ion binding]; metal-binding site 347495007674 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 347495007675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007676 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495007677 putative substrate translocation pore; other site 347495007678 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495007679 putative DNA binding site [nucleotide binding]; other site 347495007680 putative Zn2+ binding site [ion binding]; other site 347495007681 DinB superfamily; Region: DinB_2; pfam12867 347495007682 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 347495007683 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495007684 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495007685 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 347495007686 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 347495007687 putative catalytic cysteine [active] 347495007688 gamma-glutamyl kinase; Provisional; Region: PRK05429 347495007689 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 347495007690 nucleotide binding site [chemical binding]; other site 347495007691 homotetrameric interface [polypeptide binding]; other site 347495007692 putative phosphate binding site [ion binding]; other site 347495007693 putative allosteric binding site; other site 347495007694 PUA domain; Region: PUA; pfam01472 347495007695 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 347495007696 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 347495007697 potential frameshift: common BLAST hit: gi|225864959|ref|YP_002750337.1| RocB protein 347495007698 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 347495007699 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 347495007700 metal binding site [ion binding]; metal-binding site 347495007701 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 347495007702 Transcriptional regulator [Transcription]; Region: IclR; COG1414 347495007703 Bacterial transcriptional regulator; Region: IclR; pfam01614 347495007704 S-methylmethionine transporter; Provisional; Region: PRK11387 347495007705 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 347495007706 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 347495007707 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 347495007708 putative di-iron ligands [ion binding]; other site 347495007709 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 347495007710 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 347495007711 dimer interface [polypeptide binding]; other site 347495007712 active site 347495007713 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 347495007714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495007715 salt bridge; other site 347495007716 non-specific DNA binding site [nucleotide binding]; other site 347495007717 sequence-specific DNA binding site [nucleotide binding]; other site 347495007718 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 347495007719 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 347495007720 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 347495007721 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 347495007722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 347495007723 active site 347495007724 phosphorylation site [posttranslational modification] 347495007725 intermolecular recognition site; other site 347495007726 LytTr DNA-binding domain; Region: LytTR; pfam04397 347495007727 uridine kinase; Provisional; Region: PRK07667 347495007728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495007731 Coenzyme A binding pocket [chemical binding]; other site 347495007732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495007733 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 347495007734 active site 347495007735 metal binding site [ion binding]; metal-binding site 347495007736 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 347495007737 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495007738 Transcriptional regulator PadR-like family; Region: PadR; cl17335 347495007739 MoxR-like ATPases [General function prediction only]; Region: COG0714 347495007740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495007741 Walker A motif; other site 347495007742 ATP binding site [chemical binding]; other site 347495007743 Walker B motif; other site 347495007744 arginine finger; other site 347495007745 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 347495007746 Protein of unknown function DUF58; Region: DUF58; pfam01882 347495007747 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 347495007748 proline/glycine betaine transporter; Provisional; Region: PRK10642 347495007749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495007750 putative substrate translocation pore; other site 347495007751 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 347495007752 active site 347495007753 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 347495007754 active site 347495007755 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 347495007756 Ligand binding site; other site 347495007757 Putative Catalytic site; other site 347495007758 DXD motif; other site 347495007759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495007760 active site 347495007761 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 347495007762 Ligand binding site; other site 347495007763 Putative Catalytic site; other site 347495007764 DXD motif; other site 347495007765 acetylornithine aminotransferase; Provisional; Region: PRK02627 347495007766 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495007767 inhibitor-cofactor binding pocket; inhibition site 347495007768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495007769 catalytic residue [active] 347495007770 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 347495007771 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 347495007772 tetramer interface [polypeptide binding]; other site 347495007773 heme binding pocket [chemical binding]; other site 347495007774 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 347495007775 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 347495007776 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 347495007777 active site 347495007778 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 347495007779 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495007780 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495007781 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 347495007782 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495007783 Uncharacterized conserved protein [Function unknown]; Region: COG1359 347495007784 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 347495007785 dimer interface [polypeptide binding]; other site 347495007786 FMN binding site [chemical binding]; other site 347495007787 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495007788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495007789 putative DNA binding site [nucleotide binding]; other site 347495007790 putative Zn2+ binding site [ion binding]; other site 347495007791 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 347495007792 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 347495007793 G1 box; other site 347495007794 putative GEF interaction site [polypeptide binding]; other site 347495007795 GTP/Mg2+ binding site [chemical binding]; other site 347495007796 Switch I region; other site 347495007797 G2 box; other site 347495007798 G3 box; other site 347495007799 Switch II region; other site 347495007800 G4 box; other site 347495007801 G5 box; other site 347495007802 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 347495007803 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 347495007804 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 347495007805 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 347495007806 nudix motif; other site 347495007807 YfzA-like protein; Region: YfzA; pfam14118 347495007808 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 347495007809 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495007810 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495007811 Walker A/P-loop; other site 347495007812 ATP binding site [chemical binding]; other site 347495007813 Q-loop/lid; other site 347495007814 ABC transporter signature motif; other site 347495007815 Walker B; other site 347495007816 D-loop; other site 347495007817 H-loop/switch region; other site 347495007818 Predicted transcriptional regulators [Transcription]; Region: COG1725 347495007819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495007820 DNA-binding site [nucleotide binding]; DNA binding site 347495007821 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495007822 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 347495007823 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 347495007824 putative NAD(P) binding site [chemical binding]; other site 347495007825 active site 347495007826 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495007827 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495007828 Walker A/P-loop; other site 347495007829 ATP binding site [chemical binding]; other site 347495007830 Q-loop/lid; other site 347495007831 ABC transporter signature motif; other site 347495007832 Walker B; other site 347495007833 D-loop; other site 347495007834 H-loop/switch region; other site 347495007835 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 347495007836 FtsX-like permease family; Region: FtsX; pfam02687 347495007837 FtsX-like permease family; Region: FtsX; pfam02687 347495007838 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495007839 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495007840 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 347495007841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495007842 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 347495007843 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 347495007844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007845 Coenzyme A binding pocket [chemical binding]; other site 347495007846 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 347495007847 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 347495007848 nudix motif; other site 347495007849 EamA-like transporter family; Region: EamA; pfam00892 347495007850 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 347495007851 EamA-like transporter family; Region: EamA; pfam00892 347495007852 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495007853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495007854 DNA-binding site [nucleotide binding]; DNA binding site 347495007855 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495007856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495007857 homodimer interface [polypeptide binding]; other site 347495007858 catalytic residue [active] 347495007859 hypothetical protein; Validated; Region: PRK00124 347495007860 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 347495007861 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 347495007862 uridine kinase; Validated; Region: PRK06696 347495007863 active site 347495007864 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495007865 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 347495007866 active site 347495007867 metal binding site [ion binding]; metal-binding site 347495007868 Phosphotransferase enzyme family; Region: APH; pfam01636 347495007869 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495007870 active site 347495007871 substrate binding site [chemical binding]; other site 347495007872 ATP binding site [chemical binding]; other site 347495007873 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 347495007874 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495007875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495007876 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007877 Coenzyme A binding pocket [chemical binding]; other site 347495007878 lysine transporter; Provisional; Region: PRK10836 347495007879 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 347495007880 Protein of unknown function (DUF2716); Region: DUF2716; pfam10898 347495007881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 347495007882 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 347495007883 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 347495007884 putative active site [active] 347495007885 nucleotide binding site [chemical binding]; other site 347495007886 nudix motif; other site 347495007887 putative metal binding site [ion binding]; other site 347495007888 Cephalosporin hydroxylase; Region: CmcI; pfam04989 347495007889 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 347495007890 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495007891 Catalytic site [active] 347495007892 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 347495007893 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495007894 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495007895 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495007896 NAD-dependent deacetylase; Provisional; Region: PRK00481 347495007897 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 347495007898 NAD+ binding site [chemical binding]; other site 347495007899 substrate binding site [chemical binding]; other site 347495007900 Zn binding site [ion binding]; other site 347495007901 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 347495007902 putative substrate binding pocket [chemical binding]; other site 347495007903 AC domain interface; other site 347495007904 catalytic triad [active] 347495007905 AB domain interface; other site 347495007906 interchain disulfide; other site 347495007907 Predicted membrane protein [Function unknown]; Region: COG3817 347495007908 Protein of unknown function (DUF979); Region: DUF979; pfam06166 347495007909 Protein of unknown function (DUF969); Region: DUF969; pfam06149 347495007910 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 347495007911 putative active site [active] 347495007912 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 347495007913 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 347495007914 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 347495007915 Transcriptional regulator [Transcription]; Region: IclR; COG1414 347495007916 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 347495007917 Bacterial transcriptional regulator; Region: IclR; pfam01614 347495007918 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 347495007919 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495007920 Catalytic site [active] 347495007921 CutC family; Region: CutC; cl01218 347495007922 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 347495007923 stage II sporulation protein P; Region: spore_II_P; TIGR02867 347495007924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495007925 dimerization interface [polypeptide binding]; other site 347495007926 putative DNA binding site [nucleotide binding]; other site 347495007927 putative Zn2+ binding site [ion binding]; other site 347495007928 DinB superfamily; Region: DinB_2; pfam12867 347495007929 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 347495007930 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 347495007931 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 347495007932 Uncharacterized conserved protein [Function unknown]; Region: COG1434 347495007933 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 347495007934 putative active site [active] 347495007935 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495007936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495007937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 347495007938 Nucleoside recognition; Region: Gate; pfam07670 347495007939 potential frameshift: common BLAST hit: gi|301054604|ref|YP_003792815.1| phosphotransferase 347495007940 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495007941 Phosphotransferase enzyme family; Region: APH; pfam01636 347495007942 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495007943 active site 347495007944 ATP binding site [chemical binding]; other site 347495007945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495007946 Coenzyme A binding pocket [chemical binding]; other site 347495007947 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 347495007948 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 347495007949 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 347495007950 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495007951 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495007952 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 347495007953 phosphoenolpyruvate synthase; Validated; Region: PRK06241 347495007954 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 347495007955 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 347495007956 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495007957 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 347495007958 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 347495007959 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 347495007960 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 347495007961 LysE type translocator; Region: LysE; pfam01810 347495007962 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 347495007963 Spore germination protein; Region: Spore_permease; cl17796 347495007964 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495007965 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 347495007966 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 347495007967 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495007968 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 347495007969 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 347495007970 NAD binding site [chemical binding]; other site 347495007971 catalytic Zn binding site [ion binding]; other site 347495007972 structural Zn binding site [ion binding]; other site 347495007973 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 347495007974 dimanganese center [ion binding]; other site 347495007975 aspartate ammonia-lyase; Provisional; Region: PRK14515 347495007976 Aspartase; Region: Aspartase; cd01357 347495007977 active sites [active] 347495007978 tetramer interface [polypeptide binding]; other site 347495007979 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 347495007980 active site 347495007981 homodimer interface [polypeptide binding]; other site 347495007982 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495007983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495007984 non-specific DNA binding site [nucleotide binding]; other site 347495007985 salt bridge; other site 347495007986 sequence-specific DNA binding site [nucleotide binding]; other site 347495007987 Integrase core domain; Region: rve_3; cl15866 347495007988 potential frameshift: common BLAST hit: gi|118478431|ref|YP_895582.1| GerC family spore germination protein 347495007989 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495007990 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495007991 Spore germination protein; Region: Spore_permease; pfam03845 347495007992 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495007993 Bax inhibitor 1 like; Region: BaxI_1; cl17691 347495007994 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 347495007995 PAS fold; Region: PAS_4; pfam08448 347495007996 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 347495007997 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495007998 putative active site [active] 347495007999 heme pocket [chemical binding]; other site 347495008000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495008001 putative active site [active] 347495008002 heme pocket [chemical binding]; other site 347495008003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495008004 dimer interface [polypeptide binding]; other site 347495008005 phosphorylation site [posttranslational modification] 347495008006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008007 ATP binding site [chemical binding]; other site 347495008008 Mg2+ binding site [ion binding]; other site 347495008009 G-X-G motif; other site 347495008010 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495008011 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495008012 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495008013 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 347495008014 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 347495008015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495008016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495008017 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 347495008018 GIY-YIG motif/motif A; other site 347495008019 active site 347495008020 catalytic site [active] 347495008021 putative DNA binding site [nucleotide binding]; other site 347495008022 metal binding site [ion binding]; metal-binding site 347495008023 amino acid transporter; Region: 2A0306; TIGR00909 347495008024 Spore germination protein; Region: Spore_permease; cl17796 347495008025 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 347495008026 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 347495008027 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 347495008028 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 347495008029 DoxX-like family; Region: DoxX_2; pfam13564 347495008030 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 347495008031 Malic enzyme, N-terminal domain; Region: malic; pfam00390 347495008032 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 347495008033 putative NAD(P) binding site [chemical binding]; other site 347495008034 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 347495008035 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495008036 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495008037 Spore germination protein; Region: Spore_permease; pfam03845 347495008038 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495008039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008040 Response regulator receiver domain; Region: Response_reg; pfam00072 347495008041 active site 347495008042 phosphorylation site [posttranslational modification] 347495008043 intermolecular recognition site; other site 347495008044 dimerization interface [polypeptide binding]; other site 347495008045 YcbB domain; Region: YcbB; pfam08664 347495008046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495008047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008048 ATP binding site [chemical binding]; other site 347495008049 Mg2+ binding site [ion binding]; other site 347495008050 G-X-G motif; other site 347495008051 glutaminase; Reviewed; Region: PRK12357 347495008052 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 347495008053 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495008054 amino acid carrier protein; Region: agcS; TIGR00835 347495008055 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 347495008056 transmembrane helices; other site 347495008057 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 347495008058 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 347495008059 active site 347495008060 active site 347495008061 Erythromycin esterase; Region: Erythro_esteras; cl17110 347495008062 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 347495008063 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 347495008064 putative active site [active] 347495008065 putative metal binding site [ion binding]; other site 347495008066 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 347495008067 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 347495008068 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 347495008069 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 347495008070 Cl binding site [ion binding]; other site 347495008071 oligomer interface [polypeptide binding]; other site 347495008072 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 347495008073 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 347495008074 Mg binding site [ion binding]; other site 347495008075 nucleotide binding site [chemical binding]; other site 347495008076 putative protofilament interface [polypeptide binding]; other site 347495008077 Heat induced stress protein YflT; Region: YflT; pfam11181 347495008078 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 347495008079 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 347495008080 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 347495008081 TspO/MBR family; Region: TspO_MBR; pfam03073 347495008082 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 347495008083 DNA photolyase; Region: DNA_photolyase; pfam00875 347495008084 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 347495008085 NmrA-like family; Region: NmrA; pfam05368 347495008086 NADP binding site [chemical binding]; other site 347495008087 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495008088 MarR family; Region: MarR_2; pfam12802 347495008089 The Sema domain, a protein interacting module, of semaphorins and plexins; Region: Sema; cl15693 347495008090 Domain of unknown function (DUF3841); Region: DUF3841; pfam12952 347495008091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495008092 dimerization interface [polypeptide binding]; other site 347495008093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495008094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495008095 dimer interface [polypeptide binding]; other site 347495008096 phosphorylation site [posttranslational modification] 347495008097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008098 ATP binding site [chemical binding]; other site 347495008099 Mg2+ binding site [ion binding]; other site 347495008100 G-X-G motif; other site 347495008101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495008102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008103 active site 347495008104 phosphorylation site [posttranslational modification] 347495008105 intermolecular recognition site; other site 347495008106 dimerization interface [polypeptide binding]; other site 347495008107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495008108 DNA binding site [nucleotide binding] 347495008109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495008110 S-adenosylmethionine binding site [chemical binding]; other site 347495008111 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495008112 Transcriptional regulator PadR-like family; Region: PadR; cl17335 347495008113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008114 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495008115 putative substrate translocation pore; other site 347495008116 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 347495008117 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 347495008118 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 347495008119 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 347495008120 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 347495008121 zinc binding site [ion binding]; other site 347495008122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 347495008123 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 347495008124 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 347495008125 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 347495008126 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 347495008127 Protein of unknown function DUF58; Region: DUF58; pfam01882 347495008128 MoxR-like ATPases [General function prediction only]; Region: COG0714 347495008129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495008130 Walker A motif; other site 347495008131 ATP binding site [chemical binding]; other site 347495008132 Walker B motif; other site 347495008133 arginine finger; other site 347495008134 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 347495008135 UbiA prenyltransferase family; Region: UbiA; pfam01040 347495008136 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495008137 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 347495008138 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 347495008139 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 347495008140 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495008141 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495008142 Walker A/P-loop; other site 347495008143 ATP binding site [chemical binding]; other site 347495008144 Q-loop/lid; other site 347495008145 ABC transporter signature motif; other site 347495008146 Walker B; other site 347495008147 D-loop; other site 347495008148 H-loop/switch region; other site 347495008149 FtsX-like permease family; Region: FtsX; pfam02687 347495008150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495008151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008152 ATP binding site [chemical binding]; other site 347495008153 Mg2+ binding site [ion binding]; other site 347495008154 G-X-G motif; other site 347495008155 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495008156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008157 active site 347495008158 phosphorylation site [posttranslational modification] 347495008159 intermolecular recognition site; other site 347495008160 dimerization interface [polypeptide binding]; other site 347495008161 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495008162 DNA binding residues [nucleotide binding] 347495008163 dimerization interface [polypeptide binding]; other site 347495008164 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 347495008165 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 347495008166 metal binding site [ion binding]; metal-binding site 347495008167 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 347495008168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495008169 ABC-ATPase subunit interface; other site 347495008170 dimer interface [polypeptide binding]; other site 347495008171 putative PBP binding regions; other site 347495008172 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 347495008173 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 347495008174 DJ-1 family protein; Region: not_thiJ; TIGR01383 347495008175 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 347495008176 conserved cys residue [active] 347495008177 Phosphotransferase enzyme family; Region: APH; pfam01636 347495008178 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 347495008179 active site 347495008180 ATP binding site [chemical binding]; other site 347495008181 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 347495008182 active site 347495008183 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 347495008184 Low molecular weight phosphatase family; Region: LMWPc; cd00115 347495008185 active site 347495008186 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 347495008187 arsenical-resistance protein; Region: acr3; TIGR00832 347495008188 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495008189 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 347495008190 putative metal binding site [ion binding]; other site 347495008191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008192 dimerization interface [polypeptide binding]; other site 347495008193 putative DNA binding site [nucleotide binding]; other site 347495008194 putative Zn2+ binding site [ion binding]; other site 347495008195 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 347495008196 DnaJ domain; Region: DnaJ; pfam00226 347495008197 HSP70 interaction site [polypeptide binding]; other site 347495008198 TPR repeat; Region: TPR_11; pfam13414 347495008199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495008200 binding surface 347495008201 TPR motif; other site 347495008202 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 347495008203 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 347495008204 nucleotide binding site [chemical binding]; other site 347495008205 putative NEF/HSP70 interaction site [polypeptide binding]; other site 347495008206 SBD interface [polypeptide binding]; other site 347495008207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008208 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495008209 putative substrate translocation pore; other site 347495008210 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 347495008211 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 347495008212 metal binding site [ion binding]; metal-binding site 347495008213 AAA domain; Region: AAA_11; pfam13086 347495008214 Part of AAA domain; Region: AAA_19; pfam13245 347495008215 Erp protein C-terminus; Region: Erp_C; pfam06780 347495008216 AAA domain; Region: AAA_30; pfam13604 347495008217 AAA domain; Region: AAA_12; pfam13087 347495008218 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 347495008219 putative active site [active] 347495008220 catalytic site [active] 347495008221 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495008222 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 347495008223 active site 347495008224 metal binding site [ion binding]; metal-binding site 347495008225 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 347495008226 putative monooxygenase; Provisional; Region: PRK11118 347495008227 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 347495008228 Cytochrome P450; Region: p450; pfam00067 347495008229 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 347495008230 Flavodoxin; Region: Flavodoxin_1; pfam00258 347495008231 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 347495008232 FAD binding pocket [chemical binding]; other site 347495008233 FAD binding motif [chemical binding]; other site 347495008234 catalytic residues [active] 347495008235 NAD binding pocket [chemical binding]; other site 347495008236 phosphate binding motif [ion binding]; other site 347495008237 beta-alpha-beta structure motif; other site 347495008238 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495008239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008240 putative substrate translocation pore; other site 347495008241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008242 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 347495008243 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495008244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008245 active site 347495008246 phosphorylation site [posttranslational modification] 347495008247 intermolecular recognition site; other site 347495008248 dimerization interface [polypeptide binding]; other site 347495008249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495008250 DNA binding site [nucleotide binding] 347495008251 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495008252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495008253 dimerization interface [polypeptide binding]; other site 347495008254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495008255 dimer interface [polypeptide binding]; other site 347495008256 phosphorylation site [posttranslational modification] 347495008257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008258 ATP binding site [chemical binding]; other site 347495008259 G-X-G motif; other site 347495008260 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 347495008261 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 347495008262 D-cysteine desulfhydrase; Validated; Region: PRK03910 347495008263 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 347495008264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495008265 catalytic residue [active] 347495008266 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 347495008267 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495008268 active site 347495008269 metal binding site [ion binding]; metal-binding site 347495008270 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 347495008271 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008272 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008273 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 347495008274 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 347495008275 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 347495008276 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 347495008277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495008278 NAD(P) binding site [chemical binding]; other site 347495008279 active site 347495008280 hypothetical protein; Provisional; Region: PRK06849 347495008281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495008282 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 347495008283 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 347495008284 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 347495008285 dimer interface [polypeptide binding]; other site 347495008286 active site 347495008287 CoA binding pocket [chemical binding]; other site 347495008288 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 347495008289 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 347495008290 Competence protein CoiA-like family; Region: CoiA; cl11541 347495008291 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 347495008292 Restriction endonuclease; Region: Mrr_cat; pfam04471 347495008293 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 347495008294 Part of AAA domain; Region: AAA_19; pfam13245 347495008295 Family description; Region: UvrD_C_2; pfam13538 347495008296 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 347495008297 AAA ATPase domain; Region: AAA_15; pfam13175 347495008298 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 347495008299 putative active site [active] 347495008300 putative metal-binding site [ion binding]; other site 347495008301 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 347495008302 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 347495008303 AAA domain; Region: AAA_33; pfam13671 347495008304 AAA domain; Region: AAA_17; pfam13207 347495008305 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 347495008306 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 347495008307 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495008308 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495008309 Walker A/P-loop; other site 347495008310 ATP binding site [chemical binding]; other site 347495008311 Q-loop/lid; other site 347495008312 ABC transporter signature motif; other site 347495008313 Walker B; other site 347495008314 D-loop; other site 347495008315 H-loop/switch region; other site 347495008316 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 347495008317 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495008318 FtsX-like permease family; Region: FtsX; pfam02687 347495008319 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008320 dimerization interface [polypeptide binding]; other site 347495008321 putative DNA binding site [nucleotide binding]; other site 347495008322 Predicted transcriptional regulator [Transcription]; Region: COG2345 347495008323 putative Zn2+ binding site [ion binding]; other site 347495008324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008325 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495008326 putative substrate translocation pore; other site 347495008327 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 347495008328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495008329 dimerization interface [polypeptide binding]; other site 347495008330 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495008331 dimer interface [polypeptide binding]; other site 347495008332 phosphorylation site [posttranslational modification] 347495008333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008334 ATP binding site [chemical binding]; other site 347495008335 Mg2+ binding site [ion binding]; other site 347495008336 G-X-G motif; other site 347495008337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495008338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008339 active site 347495008340 phosphorylation site [posttranslational modification] 347495008341 intermolecular recognition site; other site 347495008342 dimerization interface [polypeptide binding]; other site 347495008343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495008344 DNA binding site [nucleotide binding] 347495008345 Predicted membrane protein [Function unknown]; Region: COG2364 347495008346 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495008347 Transcriptional regulators [Transcription]; Region: MarR; COG1846 347495008348 MarR family; Region: MarR; pfam01047 347495008349 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 347495008350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495008351 Coenzyme A binding pocket [chemical binding]; other site 347495008352 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 347495008353 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495008354 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495008355 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495008356 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 347495008357 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 347495008358 putative dimer interface [polypeptide binding]; other site 347495008359 catalytic triad [active] 347495008360 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 347495008361 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495008362 active site residue [active] 347495008363 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495008364 active site residue [active] 347495008365 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 347495008366 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495008367 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 347495008368 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495008369 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 347495008370 active site 347495008371 Zn binding site [ion binding]; other site 347495008372 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial homologs of mammalian glycerophosphodiester phosphodiesterase GDE4; Region: GDPD_GDE4_like_1; cd08613 347495008373 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 347495008374 putative active site [active] 347495008375 catalytic site [active] 347495008376 putative metal binding site [ion binding]; other site 347495008377 VanZ like family; Region: VanZ; pfam04892 347495008378 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495008379 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495008380 dimer interface [polypeptide binding]; other site 347495008381 phosphorylation site [posttranslational modification] 347495008382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008383 ATP binding site [chemical binding]; other site 347495008384 Mg2+ binding site [ion binding]; other site 347495008385 G-X-G motif; other site 347495008386 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495008387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008388 active site 347495008389 phosphorylation site [posttranslational modification] 347495008390 intermolecular recognition site; other site 347495008391 dimerization interface [polypeptide binding]; other site 347495008392 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495008393 DNA binding site [nucleotide binding] 347495008394 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008395 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008396 S-layer homology domain; Region: SLH; pfam00395 347495008397 S-layer homology domain; Region: SLH; pfam00395 347495008398 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495008399 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 347495008400 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 347495008401 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495008402 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 347495008403 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 347495008404 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 347495008405 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 347495008406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008407 putative substrate translocation pore; other site 347495008408 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 347495008409 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 347495008410 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 347495008411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495008412 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 347495008413 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 347495008414 inhibitor-cofactor binding pocket; inhibition site 347495008415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495008416 catalytic residue [active] 347495008417 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495008418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495008419 DNA binding site [nucleotide binding] 347495008420 domain linker motif; other site 347495008421 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 347495008422 putative dimerization interface [polypeptide binding]; other site 347495008423 putative ligand binding site [chemical binding]; other site 347495008424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495008425 TPR motif; other site 347495008426 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495008427 binding surface 347495008428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495008429 TPR motif; other site 347495008430 binding surface 347495008431 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 347495008432 PKC phosphorylation site [posttranslational modification]; other site 347495008433 DNA polymerase IV; Reviewed; Region: PRK03103 347495008434 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 347495008435 active site 347495008436 DNA binding site [nucleotide binding] 347495008437 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 347495008438 YolD-like protein; Region: YolD; pfam08863 347495008439 Tar ligand binding domain homologue; Region: TarH; pfam02203 347495008440 Cache domain; Region: Cache_1; pfam02743 347495008441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495008442 dimerization interface [polypeptide binding]; other site 347495008443 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495008444 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495008445 dimer interface [polypeptide binding]; other site 347495008446 putative CheW interface [polypeptide binding]; other site 347495008447 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 347495008448 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 347495008449 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 347495008450 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 347495008451 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 347495008452 Fic/DOC family; Region: Fic; cl00960 347495008453 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 347495008454 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 347495008455 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495008456 inhibitor-cofactor binding pocket; inhibition site 347495008457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495008458 catalytic residue [active] 347495008459 Acylphosphatase; Region: Acylphosphatase; pfam00708 347495008460 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 347495008461 HypF finger; Region: zf-HYPF; pfam07503 347495008462 HypF finger; Region: zf-HYPF; pfam07503 347495008463 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 347495008464 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 347495008465 dimerization interface [polypeptide binding]; other site 347495008466 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 347495008467 ATP binding site [chemical binding]; other site 347495008468 Isochorismatase family; Region: Isochorismatase; pfam00857 347495008469 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 347495008470 catalytic triad [active] 347495008471 conserved cis-peptide bond; other site 347495008472 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 347495008473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008474 putative DNA binding site [nucleotide binding]; other site 347495008475 putative Zn2+ binding site [ion binding]; other site 347495008476 AsnC family; Region: AsnC_trans_reg; pfam01037 347495008477 putative transporter; Provisional; Region: PRK11021 347495008478 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 347495008479 Uncharacterized conserved protein [Function unknown]; Region: COG4198 347495008480 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 347495008481 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 347495008482 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 347495008483 putative ligand binding site [chemical binding]; other site 347495008484 putative NAD binding site [chemical binding]; other site 347495008485 putative catalytic site [active] 347495008486 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 347495008487 L-serine binding site [chemical binding]; other site 347495008488 ACT domain interface; other site 347495008489 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 347495008490 homodimer interface [polypeptide binding]; other site 347495008491 substrate-cofactor binding pocket; other site 347495008492 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495008493 catalytic residue [active] 347495008494 Uncharacterized conserved protein [Function unknown]; Region: COG2155 347495008495 Cupin domain; Region: Cupin_2; cl17218 347495008496 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 347495008497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495008498 Lumazine-binding domain; Region: Lumazine_bd; pfam12870 347495008499 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 347495008500 Proteins of 100 residues with WXG; Region: WXG100; cl02005 347495008501 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 347495008502 Penicillin amidase; Region: Penicil_amidase; pfam01804 347495008503 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 347495008504 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 347495008505 active site 347495008506 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 347495008507 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 347495008508 amidase catalytic site [active] 347495008509 Zn binding residues [ion binding]; other site 347495008510 substrate binding site [chemical binding]; other site 347495008511 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495008512 S-layer homology domain; Region: SLH; pfam00395 347495008513 S-layer homology domain; Region: SLH; pfam00395 347495008514 S-layer homology domain; Region: SLH; pfam00395 347495008515 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 347495008516 A new structural DNA glycosylase; Region: AlkD_like; cd06561 347495008517 active site 347495008518 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 347495008519 S-layer homology domain; Region: SLH; pfam00395 347495008520 S-layer homology domain; Region: SLH; pfam00395 347495008521 S-layer homology domain; Region: SLH; pfam00395 347495008522 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 347495008523 putative metal binding site [ion binding]; other site 347495008524 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495008525 Domain of unknown function (DUF4279); Region: DUF4279; pfam14106 347495008526 NETI protein; Region: NETI; pfam14044 347495008527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495008529 putative substrate translocation pore; other site 347495008530 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495008531 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495008532 TAP-like protein; Region: Abhydrolase_4; pfam08386 347495008533 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495008534 MarR family; Region: MarR_2; pfam12802 347495008535 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495008536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008537 putative substrate translocation pore; other site 347495008538 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008539 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008540 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495008541 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495008542 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495008543 Walker A/P-loop; other site 347495008544 ATP binding site [chemical binding]; other site 347495008545 Q-loop/lid; other site 347495008546 ABC transporter signature motif; other site 347495008547 Walker B; other site 347495008548 D-loop; other site 347495008549 H-loop/switch region; other site 347495008550 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 347495008551 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008552 putative DNA binding site [nucleotide binding]; other site 347495008553 putative Zn2+ binding site [ion binding]; other site 347495008554 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 347495008555 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495008556 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495008557 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 347495008558 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 347495008559 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 347495008560 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 347495008561 SWIM zinc finger; Region: SWIM; pfam04434 347495008562 YwiC-like protein; Region: YwiC; pfam14256 347495008563 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 347495008564 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 347495008565 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 347495008566 Walker A/P-loop; other site 347495008567 ATP binding site [chemical binding]; other site 347495008568 Q-loop/lid; other site 347495008569 ABC transporter signature motif; other site 347495008570 Walker B; other site 347495008571 D-loop; other site 347495008572 H-loop/switch region; other site 347495008573 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 347495008574 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 347495008575 Walker A/P-loop; other site 347495008576 ATP binding site [chemical binding]; other site 347495008577 Q-loop/lid; other site 347495008578 ABC transporter signature motif; other site 347495008579 Walker B; other site 347495008580 D-loop; other site 347495008581 H-loop/switch region; other site 347495008582 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 347495008583 potential frameshift: common BLAST hit: gi|118478607|ref|YP_895758.1| cell wall anchor domain-containing protein 347495008584 Calreticulin family; Region: Calreticulin; pfam00262 347495008585 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 347495008586 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 347495008587 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 347495008588 Predicted membrane protein [Function unknown]; Region: COG1288 347495008589 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 347495008590 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 347495008591 DNA binding residues [nucleotide binding] 347495008592 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495008593 dimer interface [polypeptide binding]; other site 347495008594 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 347495008595 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495008596 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 347495008597 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495008598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495008599 non-specific DNA binding site [nucleotide binding]; other site 347495008600 salt bridge; other site 347495008601 sequence-specific DNA binding site [nucleotide binding]; other site 347495008602 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 347495008603 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 347495008604 metal binding site [ion binding]; metal-binding site 347495008605 YodA lipocalin-like domain; Region: YodA; pfam09223 347495008606 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495008607 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495008608 DNA-binding site [nucleotide binding]; DNA binding site 347495008609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495008610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495008611 homodimer interface [polypeptide binding]; other site 347495008612 catalytic residue [active] 347495008613 Proline dehydrogenase; Region: Pro_dh; cl03282 347495008614 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 347495008615 putative deacylase active site [active] 347495008616 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008617 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008618 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008619 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495008621 Histidine kinase; Region: HisKA_3; pfam07730 347495008622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495008623 ATP binding site [chemical binding]; other site 347495008624 Mg2+ binding site [ion binding]; other site 347495008625 G-X-G motif; other site 347495008626 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495008627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495008628 active site 347495008629 phosphorylation site [posttranslational modification] 347495008630 intermolecular recognition site; other site 347495008631 dimerization interface [polypeptide binding]; other site 347495008632 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495008633 DNA binding residues [nucleotide binding] 347495008634 dimerization interface [polypeptide binding]; other site 347495008635 histidyl-tRNA synthetase; Provisional; Region: PRK12420 347495008636 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 347495008637 dimer interface [polypeptide binding]; other site 347495008638 motif 1; other site 347495008639 active site 347495008640 motif 2; other site 347495008641 motif 3; other site 347495008642 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 347495008643 anticodon binding site; other site 347495008644 Predicted transcriptional regulators [Transcription]; Region: COG1733 347495008645 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 347495008646 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 347495008647 dimer interface [polypeptide binding]; other site 347495008648 FMN binding site [chemical binding]; other site 347495008649 pyruvate kinase; Validated; Region: PRK06739 347495008650 active site 347495008651 domain interfaces; other site 347495008652 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 347495008653 classical (c) SDRs; Region: SDR_c; cd05233 347495008654 NAD(P) binding site [chemical binding]; other site 347495008655 active site 347495008656 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 347495008657 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495008658 Walker A/P-loop; other site 347495008659 ATP binding site [chemical binding]; other site 347495008660 Q-loop/lid; other site 347495008661 ABC transporter signature motif; other site 347495008662 Walker B; other site 347495008663 D-loop; other site 347495008664 H-loop/switch region; other site 347495008665 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 347495008666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495008667 non-specific DNA binding site [nucleotide binding]; other site 347495008668 salt bridge; other site 347495008669 sequence-specific DNA binding site [nucleotide binding]; other site 347495008670 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 347495008671 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495008672 motif II; other site 347495008673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 347495008674 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 347495008675 Probable transposase; Region: OrfB_IS605; pfam01385 347495008676 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 347495008677 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 347495008678 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 347495008679 catalytic residues [active] 347495008680 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 347495008681 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495008682 DNA binding residues [nucleotide binding] 347495008683 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 347495008684 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 347495008685 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 347495008686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495008687 Coenzyme A binding pocket [chemical binding]; other site 347495008688 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 347495008689 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 347495008690 nudix motif; other site 347495008691 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 347495008692 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495008693 putative metal binding site [ion binding]; other site 347495008694 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 347495008695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 347495008696 maltose O-acetyltransferase; Provisional; Region: PRK10092 347495008697 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 347495008698 active site 347495008699 substrate binding site [chemical binding]; other site 347495008700 trimer interface [polypeptide binding]; other site 347495008701 CoA binding site [chemical binding]; other site 347495008702 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 347495008703 Domain of unknown function DUF20; Region: UPF0118; pfam01594 347495008704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495008705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495008706 Coenzyme A binding pocket [chemical binding]; other site 347495008707 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495008708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495008709 S-adenosylmethionine binding site [chemical binding]; other site 347495008710 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 347495008711 CGNR zinc finger; Region: zf-CGNR; pfam11706 347495008712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495008714 putative substrate translocation pore; other site 347495008715 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495008716 binding surface 347495008717 TPR motif; other site 347495008718 TPR repeat; Region: TPR_11; pfam13414 347495008719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495008720 binding surface 347495008721 Tetratricopeptide repeat; Region: TPR_16; pfam13432 347495008722 TPR motif; other site 347495008723 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 347495008724 hypothetical protein; Provisional; Region: PRK04164 347495008725 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495008726 ATP synthase I chain; Region: ATP_synt_I; cl09170 347495008727 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 347495008728 Domain of unknown function DUF21; Region: DUF21; pfam01595 347495008729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 347495008730 Transporter associated domain; Region: CorC_HlyC; smart01091 347495008731 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 347495008732 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 347495008733 DNA binding residues [nucleotide binding] 347495008734 putative dimer interface [polypeptide binding]; other site 347495008735 EamA-like transporter family; Region: EamA; pfam00892 347495008736 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 347495008737 EamA-like transporter family; Region: EamA; pfam00892 347495008738 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 347495008739 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 347495008740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 347495008741 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 347495008742 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 347495008743 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 347495008744 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 347495008745 N- and C-terminal domain interface [polypeptide binding]; other site 347495008746 active site 347495008747 catalytic site [active] 347495008748 metal binding site [ion binding]; metal-binding site 347495008749 carbohydrate binding site [chemical binding]; other site 347495008750 ATP binding site [chemical binding]; other site 347495008751 GntP family permease; Region: GntP_permease; pfam02447 347495008752 fructuronate transporter; Provisional; Region: PRK10034; cl15264 347495008753 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 347495008754 active site 347495008755 intersubunit interactions; other site 347495008756 catalytic residue [active] 347495008757 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 347495008758 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 347495008759 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 347495008760 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 347495008761 TPP-binding site [chemical binding]; other site 347495008762 dimer interface [polypeptide binding]; other site 347495008763 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 347495008764 PYR/PP interface [polypeptide binding]; other site 347495008765 dimer interface [polypeptide binding]; other site 347495008766 TPP binding site [chemical binding]; other site 347495008767 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495008768 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 347495008769 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 347495008770 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 347495008771 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 347495008772 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 347495008773 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495008774 luciferase-type oxidoreductase, BA3436 family; Region: lucif_BA3436; TIGR03571 347495008775 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 347495008776 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495008777 putative NAD(P) binding site [chemical binding]; other site 347495008778 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 347495008779 dimer interface [polypeptide binding]; other site 347495008780 FMN binding site [chemical binding]; other site 347495008781 hypothetical protein; Provisional; Region: PRK02487 347495008782 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 347495008783 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 347495008784 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 347495008785 IDEAL domain; Region: IDEAL; pfam08858 347495008786 Transcriptional regulator; Region: Rrf2; pfam02082 347495008787 Rrf2 family protein; Region: rrf2_super; TIGR00738 347495008788 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 347495008789 ArsC family; Region: ArsC; pfam03960 347495008790 putative catalytic residues [active] 347495008791 thiol/disulfide switch; other site 347495008792 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 347495008793 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495008794 DNA-binding site [nucleotide binding]; DNA binding site 347495008795 UTRA domain; Region: UTRA; pfam07702 347495008796 putative oxidoreductase; Provisional; Region: PRK10206 347495008797 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 347495008798 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 347495008799 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 347495008800 putative hydrophobic ligand binding site [chemical binding]; other site 347495008801 protein interface [polypeptide binding]; other site 347495008802 gate; other site 347495008803 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 347495008804 catalytic triad [active] 347495008805 oxyanion hole [active] 347495008806 active site 347495008807 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495008808 Phosphotransferase enzyme family; Region: APH; pfam01636 347495008809 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 347495008810 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 347495008811 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 347495008812 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 347495008813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495008814 Coenzyme A binding pocket [chemical binding]; other site 347495008815 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495008816 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495008817 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 347495008818 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495008819 acyl-activating enzyme (AAE) consensus motif; other site 347495008820 AMP binding site [chemical binding]; other site 347495008821 active site 347495008822 CoA binding site [chemical binding]; other site 347495008823 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 347495008824 Predicted transcriptional regulators [Transcription]; Region: COG1733 347495008825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008826 dimerization interface [polypeptide binding]; other site 347495008827 putative DNA binding site [nucleotide binding]; other site 347495008828 putative Zn2+ binding site [ion binding]; other site 347495008829 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008830 dimerization interface [polypeptide binding]; other site 347495008831 putative DNA binding site [nucleotide binding]; other site 347495008832 putative Zn2+ binding site [ion binding]; other site 347495008833 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 347495008834 active site 347495008835 Glyco_18 domain; Region: Glyco_18; smart00636 347495008836 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 347495008837 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 347495008838 NodB motif; other site 347495008839 putative active site [active] 347495008840 putative catalytic site [active] 347495008841 putative Zn binding site [ion binding]; other site 347495008842 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 347495008843 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 347495008844 DXD motif; other site 347495008845 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 347495008846 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 347495008847 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495008848 CAAX protease self-immunity; Region: Abi; pfam02517 347495008849 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495008850 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495008851 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 347495008852 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 347495008853 potential frameshift: common BLAST hit: gi|118478699|ref|YP_895850.1| DeoR family transcriptional regulator 347495008854 HTH domain; Region: HTH_11; pfam08279 347495008855 Protein of unknown function (DUF805); Region: DUF805; pfam05656 347495008856 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 347495008857 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 347495008858 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 347495008859 ABC-2 type transporter; Region: ABC2_membrane; cl17235 347495008860 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 347495008861 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495008862 Walker A/P-loop; other site 347495008863 ATP binding site [chemical binding]; other site 347495008864 Q-loop/lid; other site 347495008865 ABC transporter signature motif; other site 347495008866 Walker B; other site 347495008867 D-loop; other site 347495008868 H-loop/switch region; other site 347495008869 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 347495008870 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495008871 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495008872 hydroxylamine reductase; Provisional; Region: PRK12310 347495008873 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 347495008874 ACS interaction site; other site 347495008875 CODH interaction site; other site 347495008876 metal cluster binding site [ion binding]; other site 347495008877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 347495008878 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 347495008879 Probable transposase; Region: OrfB_IS605; pfam01385 347495008880 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495008881 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 347495008882 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 347495008883 active site 347495008884 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 347495008885 metal binding site [ion binding]; metal-binding site 347495008886 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 347495008887 hypothetical protein; Provisional; Region: PRK06771 347495008888 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008889 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008890 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 347495008891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 347495008892 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 347495008893 dimer interface [polypeptide binding]; other site 347495008894 ligand binding site [chemical binding]; other site 347495008895 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 347495008896 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 347495008897 ligand binding site [chemical binding]; other site 347495008898 flexible hinge region; other site 347495008899 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 347495008900 Protein of unknown function, DUF606; Region: DUF606; pfam04657 347495008901 Protein of unknown function, DUF606; Region: DUF606; pfam04657 347495008902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495008903 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 347495008904 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 347495008905 putative NAD(P) binding site [chemical binding]; other site 347495008906 dimer interface [polypeptide binding]; other site 347495008907 putative transport protein YifK; Provisional; Region: PRK10746 347495008908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008909 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 347495008910 putative substrate translocation pore; other site 347495008911 Haemolysin XhlA; Region: XhlA; pfam10779 347495008912 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 347495008913 classical (c) SDRs; Region: SDR_c; cd05233 347495008914 NAD(P) binding site [chemical binding]; other site 347495008915 active site 347495008916 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 347495008917 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 347495008918 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 347495008919 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 347495008920 transmembrane helices; other site 347495008921 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495008922 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495008923 Coenzyme A binding pocket [chemical binding]; other site 347495008924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495008925 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495008926 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 347495008927 putative ligand binding residues [chemical binding]; other site 347495008928 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 347495008929 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495008930 ABC-ATPase subunit interface; other site 347495008931 dimer interface [polypeptide binding]; other site 347495008932 putative PBP binding regions; other site 347495008933 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495008934 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495008935 ABC-ATPase subunit interface; other site 347495008936 dimer interface [polypeptide binding]; other site 347495008937 putative PBP binding regions; other site 347495008938 Protein of unknown function (DUF817); Region: DUF817; pfam05675 347495008939 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 347495008940 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 347495008941 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 347495008942 DinB superfamily; Region: DinB_2; pfam12867 347495008943 DinB family; Region: DinB; cl17821 347495008944 DinB superfamily; Region: DinB_2; pfam12867 347495008945 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495008946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495008947 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495008948 dimerization interface [polypeptide binding]; other site 347495008949 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495008950 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 347495008951 NADP binding site [chemical binding]; other site 347495008952 dimer interface [polypeptide binding]; other site 347495008953 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495008954 catalytic core [active] 347495008955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495008956 Coenzyme A binding pocket [chemical binding]; other site 347495008957 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 347495008958 MutS domain III; Region: MutS_III; pfam05192 347495008959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495008960 Walker A/P-loop; other site 347495008961 ATP binding site [chemical binding]; other site 347495008962 Q-loop/lid; other site 347495008963 ABC transporter signature motif; other site 347495008964 Walker B; other site 347495008965 D-loop; other site 347495008966 H-loop/switch region; other site 347495008967 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 347495008968 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 347495008969 active site 347495008970 Na/Ca binding site [ion binding]; other site 347495008971 catalytic site [active] 347495008972 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 347495008973 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 347495008974 oligoendopeptidase F; Region: pepF; TIGR00181 347495008975 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 347495008976 active site 347495008977 Zn binding site [ion binding]; other site 347495008978 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 347495008979 Beta-lactamase; Region: Beta-lactamase; pfam00144 347495008980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495008981 putative substrate translocation pore; other site 347495008982 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495008983 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495008984 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495008985 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 347495008986 putative dimerization interface [polypeptide binding]; other site 347495008987 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 347495008988 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 347495008989 putative active site [active] 347495008990 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 347495008991 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 347495008992 active site 347495008993 catalytic site [active] 347495008994 metal binding site [ion binding]; metal-binding site 347495008995 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 347495008996 FAD binding domain; Region: FAD_binding_3; pfam01494 347495008997 hypothetical protein; Provisional; Region: PRK07236 347495008998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495008999 dimerization interface [polypeptide binding]; other site 347495009000 putative DNA binding site [nucleotide binding]; other site 347495009001 putative Zn2+ binding site [ion binding]; other site 347495009002 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 347495009003 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 347495009004 putative NAD(P) binding site [chemical binding]; other site 347495009005 Uncharacterized conserved protein [Function unknown]; Region: COG0397 347495009006 hypothetical protein; Validated; Region: PRK00029 347495009007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495009008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495009009 TPR motif; other site 347495009010 binding surface 347495009011 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 347495009012 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 347495009013 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 347495009014 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 347495009015 Sodium Bile acid symporter family; Region: SBF; cl17470 347495009016 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 347495009017 FAD binding domain; Region: FAD_binding_4; pfam01565 347495009018 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 347495009019 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 347495009020 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 347495009021 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 347495009022 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 347495009023 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 347495009024 trimer interface [polypeptide binding]; other site 347495009025 active site 347495009026 substrate binding site [chemical binding]; other site 347495009027 CoA binding site [chemical binding]; other site 347495009028 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 347495009029 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 347495009030 inhibitor-cofactor binding pocket; inhibition site 347495009031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495009032 catalytic residue [active] 347495009033 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 347495009034 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 347495009035 active site 347495009036 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 347495009037 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495009038 active site 347495009039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495009040 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495009041 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 347495009042 enoyl-CoA hydratase; Provisional; Region: PRK06688 347495009043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495009044 substrate binding site [chemical binding]; other site 347495009045 oxyanion hole (OAH) forming residues; other site 347495009046 trimer interface [polypeptide binding]; other site 347495009047 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 347495009048 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 347495009049 FOG: PKD repeat [General function prediction only]; Region: COG3291 347495009050 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 347495009051 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 347495009052 MgtC family; Region: MgtC; pfam02308 347495009053 Predicted acetyltransferase [General function prediction only]; Region: COG3981 347495009054 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495009055 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 347495009056 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 347495009057 putative metal binding site [ion binding]; other site 347495009058 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495009059 active site 347495009060 metal binding site [ion binding]; metal-binding site 347495009061 VanW like protein; Region: VanW; pfam04294 347495009062 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 347495009063 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 347495009064 exonuclease; Provisional; Region: PRK06722 347495009065 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 347495009066 active site 347495009067 catalytic site [active] 347495009068 substrate binding site [chemical binding]; other site 347495009069 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 347495009070 DNA-binding site [nucleotide binding]; DNA binding site 347495009071 RNA-binding motif; other site 347495009072 flavodoxin; Provisional; Region: PRK06703 347495009073 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 347495009074 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 347495009075 nudix motif; other site 347495009076 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 347495009077 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 347495009078 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 347495009079 trimer interface [polypeptide binding]; other site 347495009080 active site 347495009081 substrate binding site [chemical binding]; other site 347495009082 CoA binding site [chemical binding]; other site 347495009083 HTH-like domain; Region: HTH_21; pfam13276 347495009084 Integrase core domain; Region: rve; pfam00665 347495009085 Integrase core domain; Region: rve_3; cl15866 347495009086 Haemolysin XhlA; Region: XhlA; pfam10779 347495009087 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495009088 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495009089 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 347495009090 N-acetyl-D-glucosamine binding site [chemical binding]; other site 347495009091 catalytic residue [active] 347495009092 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 347495009093 active site 347495009094 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 347495009095 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495009096 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495009097 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 347495009098 N-acetyl-D-glucosamine binding site [chemical binding]; other site 347495009099 catalytic residue [active] 347495009100 Helix-turn-helix domain; Region: HTH_36; pfam13730 347495009101 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 347495009102 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495009103 sequence-specific DNA binding site [nucleotide binding]; other site 347495009104 salt bridge; other site 347495009105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495009106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495009107 non-specific DNA binding site [nucleotide binding]; other site 347495009108 salt bridge; other site 347495009109 sequence-specific DNA binding site [nucleotide binding]; other site 347495009110 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 347495009111 Domain of unknown function (DUF955); Region: DUF955; cl01076 347495009112 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009113 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009114 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009115 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009116 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009117 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009118 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009119 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009120 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009121 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009122 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009123 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009124 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009125 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009126 short chain dehydrogenase; Provisional; Region: PRK06924 347495009127 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 347495009128 NADP binding site [chemical binding]; other site 347495009129 homodimer interface [polypeptide binding]; other site 347495009130 active site 347495009131 Predicted acetyltransferase [General function prediction only]; Region: COG3393 347495009132 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495009133 argininosuccinate lyase; Provisional; Region: PRK06705 347495009134 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 347495009135 active sites [active] 347495009136 tetramer interface [polypeptide binding]; other site 347495009137 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495009138 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495009139 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 347495009140 active site 347495009141 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 347495009142 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 347495009143 Na binding site [ion binding]; other site 347495009144 Protein of unknown function (DUF997); Region: DUF997; pfam06196 347495009145 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 347495009146 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 347495009147 NAD(P) binding site [chemical binding]; other site 347495009148 catalytic residues [active] 347495009149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 347495009150 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 347495009151 NAD(P) binding site [chemical binding]; other site 347495009152 homotetramer interface [polypeptide binding]; other site 347495009153 homodimer interface [polypeptide binding]; other site 347495009154 active site 347495009155 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 347495009156 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 347495009157 Divergent PAP2 family; Region: DUF212; pfam02681 347495009158 Predicted permeases [General function prediction only]; Region: RarD; COG2962 347495009159 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 347495009160 antiporter inner membrane protein; Provisional; Region: PRK11670 347495009161 Domain of unknown function DUF59; Region: DUF59; pfam01883 347495009162 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 347495009163 Walker A motif; other site 347495009164 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 347495009165 MoaE interaction surface [polypeptide binding]; other site 347495009166 MoeB interaction surface [polypeptide binding]; other site 347495009167 thiocarboxylated glycine; other site 347495009168 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 347495009169 MoaE homodimer interface [polypeptide binding]; other site 347495009170 MoaD interaction [polypeptide binding]; other site 347495009171 active site residues [active] 347495009172 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 347495009173 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 347495009174 dimer interface [polypeptide binding]; other site 347495009175 putative functional site; other site 347495009176 putative MPT binding site; other site 347495009177 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 347495009178 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 347495009179 ATP binding site [chemical binding]; other site 347495009180 substrate interface [chemical binding]; other site 347495009181 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 347495009182 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 347495009183 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495009184 FeS/SAM binding site; other site 347495009185 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 347495009186 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 347495009187 Uncharacterized conserved protein [Function unknown]; Region: COG5609 347495009188 Uncharacterized conserved protein [Function unknown]; Region: COG2427 347495009189 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 347495009190 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 347495009191 catalytic loop [active] 347495009192 iron binding site [ion binding]; other site 347495009193 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 347495009194 4Fe-4S binding domain; Region: Fer4; pfam00037 347495009195 4Fe-4S binding domain; Region: Fer4; pfam00037 347495009196 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 347495009197 [4Fe-4S] binding site [ion binding]; other site 347495009198 molybdopterin cofactor binding site; other site 347495009199 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 347495009200 molybdopterin cofactor binding site; other site 347495009201 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495009202 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 347495009203 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495009204 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495009205 Tubulin like; Region: Tubulin_2; pfam13809 347495009206 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 347495009207 metal ion-dependent adhesion site (MIDAS); other site 347495009208 Methyltransferase domain; Region: Methyltransf_31; pfam13847 347495009209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495009210 S-adenosylmethionine binding site [chemical binding]; other site 347495009211 O-methyltransferase; Region: Methyltransf_2; pfam00891 347495009212 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495009213 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495009214 peptide binding site [polypeptide binding]; other site 347495009215 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495009216 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495009217 peptide binding site [polypeptide binding]; other site 347495009218 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 347495009219 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 347495009220 peptide binding site [polypeptide binding]; other site 347495009221 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 347495009222 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 347495009223 Transcriptional regulator [Transcription]; Region: LytR; COG1316 347495009224 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 347495009225 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495009226 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495009227 DNA binding residues [nucleotide binding] 347495009228 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 347495009229 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495009230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495009231 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495009232 Walker A/P-loop; other site 347495009233 ATP binding site [chemical binding]; other site 347495009234 Q-loop/lid; other site 347495009235 ABC transporter signature motif; other site 347495009236 Walker B; other site 347495009237 D-loop; other site 347495009238 H-loop/switch region; other site 347495009239 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495009240 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495009241 putative oxidoreductase; Provisional; Region: PRK11579 347495009242 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 347495009243 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 347495009244 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 347495009245 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 347495009246 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 347495009247 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 347495009248 CAP-like domain; other site 347495009249 active site 347495009250 primary dimer interface [polypeptide binding]; other site 347495009251 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495009252 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495009253 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495009254 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 347495009255 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 347495009256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495009257 ATP binding site [chemical binding]; other site 347495009258 Mg2+ binding site [ion binding]; other site 347495009259 G-X-G motif; other site 347495009260 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 347495009261 anchoring element; other site 347495009262 dimer interface [polypeptide binding]; other site 347495009263 ATP binding site [chemical binding]; other site 347495009264 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 347495009265 active site 347495009266 putative metal-binding site [ion binding]; other site 347495009267 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 347495009268 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 347495009269 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 347495009270 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 347495009271 protein binding site [polypeptide binding]; other site 347495009272 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495009273 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495009274 active site 347495009275 phosphorylation site [posttranslational modification] 347495009276 intermolecular recognition site; other site 347495009277 dimerization interface [polypeptide binding]; other site 347495009278 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495009279 DNA binding site [nucleotide binding] 347495009280 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 347495009281 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495009282 FeS/SAM binding site; other site 347495009283 potential frameshift: common BLAST hit: gi|225865584|ref|YP_002750962.1| anaerobic ribonucleoside triphosphate reductase 347495009284 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 347495009285 potential frameshift: common BLAST hit: gi|301055089|ref|YP_003793300.1| anaerobic ribonucleoside triphosphate reductase 347495009286 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 347495009287 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 347495009288 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 347495009289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 347495009290 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 347495009291 active site 347495009292 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 347495009293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495009294 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495009295 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 347495009296 active site 347495009297 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 347495009298 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 347495009299 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 347495009300 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 347495009301 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 347495009302 active site 347495009303 catalytic site [active] 347495009304 substrate binding site [chemical binding]; other site 347495009305 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 347495009306 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 347495009307 catalytic residues [active] 347495009308 Family of unknown function (DUF648); Region: DUF648; pfam04890 347495009309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495009310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495009311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495009312 Walker A/P-loop; other site 347495009313 ATP binding site [chemical binding]; other site 347495009314 Q-loop/lid; other site 347495009315 ABC transporter signature motif; other site 347495009316 Walker B; other site 347495009317 D-loop; other site 347495009318 H-loop/switch region; other site 347495009319 aconitate hydratase; Validated; Region: PRK09277 347495009320 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 347495009321 substrate binding site [chemical binding]; other site 347495009322 ligand binding site [chemical binding]; other site 347495009323 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 347495009324 substrate binding site [chemical binding]; other site 347495009325 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 347495009326 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495009327 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 347495009328 NodB motif; other site 347495009329 active site 347495009330 catalytic site [active] 347495009331 metal binding site [ion binding]; metal-binding site 347495009332 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 347495009333 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 347495009334 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 347495009335 putative dimer interface [polypeptide binding]; other site 347495009336 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 347495009337 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 347495009338 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 347495009339 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 347495009340 nudix motif; other site 347495009341 SAP domain; Region: SAP; pfam02037 347495009342 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 347495009343 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 347495009344 dimer interface [polypeptide binding]; other site 347495009345 active site 347495009346 acyl-CoA synthetase; Validated; Region: PRK07638 347495009347 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495009348 acyl-activating enzyme (AAE) consensus motif; other site 347495009349 AMP binding site [chemical binding]; other site 347495009350 active site 347495009351 CoA binding site [chemical binding]; other site 347495009352 BioY family; Region: BioY; pfam02632 347495009353 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 347495009354 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 347495009355 dimer interface [polypeptide binding]; other site 347495009356 acyl-activating enzyme (AAE) consensus motif; other site 347495009357 putative active site [active] 347495009358 AMP binding site [chemical binding]; other site 347495009359 putative CoA binding site [chemical binding]; other site 347495009360 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 347495009361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495009362 H-loop/switch region; other site 347495009363 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495009364 Coenzyme A binding pocket [chemical binding]; other site 347495009365 S-layer homology domain; Region: SLH; pfam00395 347495009366 S-layer homology domain; Region: SLH; pfam00395 347495009367 S-layer homology domain; Region: SLH; pfam00395 347495009368 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 347495009369 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 347495009370 amidase catalytic site [active] 347495009371 Zn binding residues [ion binding]; other site 347495009372 substrate binding site [chemical binding]; other site 347495009373 active site 347495009374 Protein phosphatase 2C; Region: PP2C_2; pfam13672 347495009375 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495009376 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495009377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495009378 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 347495009379 dimer interface [polypeptide binding]; other site 347495009380 putative metal binding site [ion binding]; other site 347495009381 PAS domain S-box; Region: sensory_box; TIGR00229 347495009382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495009383 putative active site [active] 347495009384 heme pocket [chemical binding]; other site 347495009385 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 347495009386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495009387 putative active site [active] 347495009388 heme pocket [chemical binding]; other site 347495009389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495009390 dimer interface [polypeptide binding]; other site 347495009391 phosphorylation site [posttranslational modification] 347495009392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495009393 ATP binding site [chemical binding]; other site 347495009394 Mg2+ binding site [ion binding]; other site 347495009395 G-X-G motif; other site 347495009396 Predicted esterase [General function prediction only]; Region: COG0400 347495009397 putative hydrolase; Provisional; Region: PRK11460 347495009398 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 347495009399 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495009400 Zn binding site [ion binding]; other site 347495009401 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 347495009402 Zn binding site [ion binding]; other site 347495009403 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 347495009404 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 347495009405 Na binding site [ion binding]; other site 347495009406 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 347495009407 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 347495009408 active site 347495009409 FMN binding site [chemical binding]; other site 347495009410 substrate binding site [chemical binding]; other site 347495009411 3Fe-4S cluster binding site [ion binding]; other site 347495009412 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 347495009413 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 347495009414 FMN binding site [chemical binding]; other site 347495009415 active site 347495009416 substrate binding site [chemical binding]; other site 347495009417 catalytic residue [active] 347495009418 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 347495009419 Agmatinase-like family; Region: Agmatinase-like; cd09990 347495009420 active site 347495009421 oligomer interface [polypeptide binding]; other site 347495009422 Mn binding site [ion binding]; other site 347495009423 imidazolonepropionase; Validated; Region: PRK09356 347495009424 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 347495009425 active site 347495009426 urocanate hydratase; Provisional; Region: PRK05414 347495009427 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 347495009428 active sites [active] 347495009429 tetramer interface [polypeptide binding]; other site 347495009430 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 347495009431 hexamer interface [polypeptide binding]; other site 347495009432 RNA binding site [nucleotide binding]; other site 347495009433 Histidine-zinc binding site [chemical binding]; other site 347495009434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495009435 S-adenosylmethionine binding site [chemical binding]; other site 347495009436 DJ-1 family protein; Region: not_thiJ; TIGR01383 347495009437 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 347495009438 conserved cys residue [active] 347495009439 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 347495009440 AAA domain; Region: AAA_28; pfam13521 347495009441 active site 347495009442 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 347495009443 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009444 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009445 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009446 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009447 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009448 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009449 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009450 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009451 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009452 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009453 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009454 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009455 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009456 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495009457 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 347495009458 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 347495009459 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 347495009460 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 347495009461 EamA-like transporter family; Region: EamA; pfam00892 347495009462 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 347495009463 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 347495009464 metal binding site [ion binding]; metal-binding site 347495009465 dimer interface [polypeptide binding]; other site 347495009466 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 347495009467 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495009468 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495009469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495009470 Walker A/P-loop; other site 347495009471 ATP binding site [chemical binding]; other site 347495009472 Q-loop/lid; other site 347495009473 ABC transporter signature motif; other site 347495009474 Walker B; other site 347495009475 D-loop; other site 347495009476 H-loop/switch region; other site 347495009477 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 347495009478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495009479 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 347495009480 putative dimerization interface [polypeptide binding]; other site 347495009481 putative substrate binding pocket [chemical binding]; other site 347495009482 holin-like protein; Validated; Region: PRK01658 347495009483 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 347495009484 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 347495009485 nudix motif; other site 347495009486 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 347495009487 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 347495009488 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 347495009489 amidase catalytic site [active] 347495009490 Zn binding residues [ion binding]; other site 347495009491 substrate binding site [chemical binding]; other site 347495009492 S-layer homology domain; Region: SLH; pfam00395 347495009493 S-layer homology domain; Region: SLH; pfam00395 347495009494 S-layer homology domain; Region: SLH; pfam00395 347495009495 Nuclease-related domain; Region: NERD; pfam08378 347495009496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495009497 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495009498 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 347495009499 Walker A/P-loop; other site 347495009500 ATP binding site [chemical binding]; other site 347495009501 Q-loop/lid; other site 347495009502 ABC transporter signature motif; other site 347495009503 Walker B; other site 347495009504 D-loop; other site 347495009505 H-loop/switch region; other site 347495009506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495009507 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 347495009508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495009509 Walker A/P-loop; other site 347495009510 ATP binding site [chemical binding]; other site 347495009511 Q-loop/lid; other site 347495009512 ABC transporter signature motif; other site 347495009513 Walker B; other site 347495009514 D-loop; other site 347495009515 H-loop/switch region; other site 347495009516 hypothetical protein; Provisional; Region: PRK01844 347495009517 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 347495009518 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 347495009519 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 347495009520 TPP-binding site [chemical binding]; other site 347495009521 dimer interface [polypeptide binding]; other site 347495009522 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 347495009523 PYR/PP interface [polypeptide binding]; other site 347495009524 dimer interface [polypeptide binding]; other site 347495009525 TPP binding site [chemical binding]; other site 347495009526 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495009527 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 347495009528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495009529 dimer interface [polypeptide binding]; other site 347495009530 conserved gate region; other site 347495009531 ABC-ATPase subunit interface; other site 347495009532 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 347495009533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495009534 dimer interface [polypeptide binding]; other site 347495009535 conserved gate region; other site 347495009536 ABC-ATPase subunit interface; other site 347495009537 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 347495009538 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 347495009539 Walker A/P-loop; other site 347495009540 ATP binding site [chemical binding]; other site 347495009541 Q-loop/lid; other site 347495009542 ABC transporter signature motif; other site 347495009543 Walker B; other site 347495009544 D-loop; other site 347495009545 H-loop/switch region; other site 347495009546 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 347495009547 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495009548 membrane-bound complex binding site; other site 347495009549 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 347495009550 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 347495009551 active site 347495009552 metal binding site [ion binding]; metal-binding site 347495009553 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 347495009554 hypothetical protein; Provisional; Region: PRK01546 347495009555 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 347495009556 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 347495009557 catalytic residues [active] 347495009558 catalytic nucleophile [active] 347495009559 LexA repressor; Validated; Region: PRK00215 347495009560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495009561 putative DNA binding site [nucleotide binding]; other site 347495009562 putative Zn2+ binding site [ion binding]; other site 347495009563 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 347495009564 Catalytic site [active] 347495009565 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 347495009566 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 347495009567 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 347495009568 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495009569 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495009570 glutamine synthetase, type I; Region: GlnA; TIGR00653 347495009571 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 347495009572 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 347495009573 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 347495009574 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495009575 DNA binding residues [nucleotide binding] 347495009576 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 347495009577 Aluminium resistance protein; Region: Alum_res; pfam06838 347495009578 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 347495009579 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 347495009580 HflX GTPase family; Region: HflX; cd01878 347495009581 G1 box; other site 347495009582 GTP/Mg2+ binding site [chemical binding]; other site 347495009583 Switch I region; other site 347495009584 G2 box; other site 347495009585 G3 box; other site 347495009586 Switch II region; other site 347495009587 G4 box; other site 347495009588 G5 box; other site 347495009589 Predicted membrane protein [Function unknown]; Region: COG2860 347495009590 UPF0126 domain; Region: UPF0126; pfam03458 347495009591 UPF0126 domain; Region: UPF0126; pfam03458 347495009592 stage V sporulation protein K; Region: spore_V_K; TIGR02881 347495009593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495009594 Walker A motif; other site 347495009595 ATP binding site [chemical binding]; other site 347495009596 Walker B motif; other site 347495009597 arginine finger; other site 347495009598 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 347495009599 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 347495009600 active site 347495009601 catalytic residues [active] 347495009602 DNA binding site [nucleotide binding] 347495009603 Int/Topo IB signature motif; other site 347495009604 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 347495009605 bacterial Hfq-like; Region: Hfq; cd01716 347495009606 hexamer interface [polypeptide binding]; other site 347495009607 Sm1 motif; other site 347495009608 RNA binding site [nucleotide binding]; other site 347495009609 Sm2 motif; other site 347495009610 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 347495009611 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 347495009612 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495009613 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495009614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 347495009615 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 347495009616 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 347495009617 active site 347495009618 phosphorylation site [posttranslational modification] 347495009619 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 347495009620 active site 347495009621 P-loop; other site 347495009622 phosphorylation site [posttranslational modification] 347495009623 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 347495009624 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 347495009625 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 347495009626 putative substrate binding site [chemical binding]; other site 347495009627 putative ATP binding site [chemical binding]; other site 347495009628 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 347495009629 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 347495009630 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 347495009631 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 347495009632 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 347495009633 dimer interface [polypeptide binding]; other site 347495009634 active site 347495009635 metal binding site [ion binding]; metal-binding site 347495009636 Predicted membrane protein [Function unknown]; Region: COG2322 347495009637 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 347495009638 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 347495009639 Glyco_18 domain; Region: Glyco_18; smart00636 347495009640 putative active site [active] 347495009641 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 347495009642 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 347495009643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495009644 putative active site [active] 347495009645 putative metal binding site [ion binding]; other site 347495009646 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 347495009647 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 347495009648 IHF dimer interface [polypeptide binding]; other site 347495009649 IHF - DNA interface [nucleotide binding]; other site 347495009650 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 347495009651 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 347495009652 metal-binding site [ion binding] 347495009653 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 347495009654 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 347495009655 metal-binding site [ion binding] 347495009656 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495009657 Soluble P-type ATPase [General function prediction only]; Region: COG4087 347495009658 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 347495009659 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 347495009660 metal-binding site [ion binding] 347495009661 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 347495009662 putative homodimer interface [polypeptide binding]; other site 347495009663 putative homotetramer interface [polypeptide binding]; other site 347495009664 putative allosteric switch controlling residues; other site 347495009665 putative metal binding site [ion binding]; other site 347495009666 putative homodimer-homodimer interface [polypeptide binding]; other site 347495009667 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 347495009668 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 347495009669 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 347495009670 Walker A/P-loop; other site 347495009671 ATP binding site [chemical binding]; other site 347495009672 Q-loop/lid; other site 347495009673 ABC transporter signature motif; other site 347495009674 Walker B; other site 347495009675 D-loop; other site 347495009676 H-loop/switch region; other site 347495009677 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495009678 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495009679 ABC-ATPase subunit interface; other site 347495009680 dimer interface [polypeptide binding]; other site 347495009681 putative PBP binding regions; other site 347495009682 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495009683 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495009684 ABC-ATPase subunit interface; other site 347495009685 dimer interface [polypeptide binding]; other site 347495009686 putative PBP binding regions; other site 347495009687 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495009688 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 347495009689 putative ligand binding residues [chemical binding]; other site 347495009690 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 347495009691 active site 347495009692 putative catalytic site [active] 347495009693 DNA binding site [nucleotide binding] 347495009694 putative phosphate binding site [ion binding]; other site 347495009695 metal binding site A [ion binding]; metal-binding site 347495009696 AP binding site [nucleotide binding]; other site 347495009697 metal binding site B [ion binding]; metal-binding site 347495009698 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 347495009699 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 347495009700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495009701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495009702 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 347495009703 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 347495009704 DNA binding site [nucleotide binding] 347495009705 active site 347495009706 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 347495009707 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 347495009708 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 347495009709 minor groove reading motif; other site 347495009710 helix-hairpin-helix signature motif; other site 347495009711 substrate binding pocket [chemical binding]; other site 347495009712 active site 347495009713 peptidase T; Region: peptidase-T; TIGR01882 347495009714 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 347495009715 metal binding site [ion binding]; metal-binding site 347495009716 dimer interface [polypeptide binding]; other site 347495009717 Predicted membrane protein [Function unknown]; Region: COG2364 347495009718 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495009719 hypothetical protein; Provisional; Region: PRK06764 347495009720 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495009721 catalytic core [active] 347495009722 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495009723 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495009724 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 347495009725 active site 347495009726 PAS domain S-box; Region: sensory_box; TIGR00229 347495009727 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495009728 putative active site [active] 347495009729 heme pocket [chemical binding]; other site 347495009730 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495009731 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495009732 metal binding site [ion binding]; metal-binding site 347495009733 active site 347495009734 I-site; other site 347495009735 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495009736 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 347495009737 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 347495009738 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 347495009739 holin-like protein; Validated; Region: PRK01658 347495009740 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 347495009741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495009742 DNA-binding site [nucleotide binding]; DNA binding site 347495009743 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495009744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495009745 homodimer interface [polypeptide binding]; other site 347495009746 catalytic residue [active] 347495009747 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495009748 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 347495009749 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 347495009750 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 347495009751 active site 347495009752 catalytic site [active] 347495009753 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 347495009754 putative active site [active] 347495009755 putative catalytic triad [active] 347495009756 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 347495009757 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495009758 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 347495009759 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495009760 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 347495009761 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 347495009762 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 347495009763 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 347495009764 Sulfatase; Region: Sulfatase; pfam00884 347495009765 Tetratricopeptide repeat; Region: TPR_16; pfam13432 347495009766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495009767 binding surface 347495009768 TPR motif; other site 347495009769 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 347495009770 G1 box; other site 347495009771 GTP/Mg2+ binding site [chemical binding]; other site 347495009772 Switch I region; other site 347495009773 G3 box; other site 347495009774 Switch II region; other site 347495009775 G4 box; other site 347495009776 G5 box; other site 347495009777 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 347495009778 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 347495009779 active site 347495009780 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 347495009781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495009782 ATP binding site [chemical binding]; other site 347495009783 Mg2+ binding site [ion binding]; other site 347495009784 G-X-G motif; other site 347495009785 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 347495009786 ATP binding site [chemical binding]; other site 347495009787 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 347495009788 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 347495009789 MutS domain I; Region: MutS_I; pfam01624 347495009790 MutS domain II; Region: MutS_II; pfam05188 347495009791 MutS domain III; Region: MutS_III; pfam05192 347495009792 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 347495009793 Walker A/P-loop; other site 347495009794 ATP binding site [chemical binding]; other site 347495009795 Q-loop/lid; other site 347495009796 ABC transporter signature motif; other site 347495009797 Walker B; other site 347495009798 D-loop; other site 347495009799 H-loop/switch region; other site 347495009800 Outer spore coat protein E (CotE); Region: CotE; pfam10628 347495009801 Predicted membrane protein [Function unknown]; Region: COG4550 347495009802 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 347495009803 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 347495009804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495009805 FeS/SAM binding site; other site 347495009806 TRAM domain; Region: TRAM; pfam01938 347495009807 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 347495009808 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 347495009809 TPP-binding site [chemical binding]; other site 347495009810 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 347495009811 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 347495009812 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 347495009813 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 347495009814 dimer interface [polypeptide binding]; other site 347495009815 PYR/PP interface [polypeptide binding]; other site 347495009816 TPP binding site [chemical binding]; other site 347495009817 substrate binding site [chemical binding]; other site 347495009818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495009819 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 347495009820 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 347495009821 active site 347495009822 dimer interface [polypeptide binding]; other site 347495009823 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 347495009824 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 347495009825 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 347495009826 putative active site [active] 347495009827 metal binding site [ion binding]; metal-binding site 347495009828 homodimer binding site [polypeptide binding]; other site 347495009829 phosphodiesterase; Provisional; Region: PRK12704 347495009830 Uncharacterized conserved protein [Function unknown]; Region: COG3334 347495009831 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495009832 Zn2+ binding site [ion binding]; other site 347495009833 Mg2+ binding site [ion binding]; other site 347495009834 recombinase A; Provisional; Region: recA; PRK09354 347495009835 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 347495009836 hexamer interface [polypeptide binding]; other site 347495009837 Walker A motif; other site 347495009838 ATP binding site [chemical binding]; other site 347495009839 Walker B motif; other site 347495009840 competence damage-inducible protein A; Provisional; Region: PRK00549 347495009841 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 347495009842 putative MPT binding site; other site 347495009843 Competence-damaged protein; Region: CinA; pfam02464 347495009844 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 347495009845 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 347495009846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495009847 non-specific DNA binding site [nucleotide binding]; other site 347495009848 salt bridge; other site 347495009849 sequence-specific DNA binding site [nucleotide binding]; other site 347495009850 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 347495009851 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 347495009852 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 347495009853 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 347495009854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495009855 NAD(P) binding site [chemical binding]; other site 347495009856 active site 347495009857 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 347495009858 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 347495009859 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 347495009860 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 347495009861 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 347495009862 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 347495009863 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 347495009864 TM-ABC transporter signature motif; other site 347495009865 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 347495009866 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 347495009867 TM-ABC transporter signature motif; other site 347495009868 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 347495009869 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 347495009870 Walker A/P-loop; other site 347495009871 ATP binding site [chemical binding]; other site 347495009872 Q-loop/lid; other site 347495009873 ABC transporter signature motif; other site 347495009874 Walker B; other site 347495009875 D-loop; other site 347495009876 H-loop/switch region; other site 347495009877 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 347495009878 potential frameshift: common BLAST hit: gi|301055282|ref|YP_003793493.1| Bmp family lipoprotein 347495009879 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 347495009880 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 347495009881 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 347495009882 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 347495009883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495009884 DNA-binding site [nucleotide binding]; DNA binding site 347495009885 UTRA domain; Region: UTRA; pfam07702 347495009886 Tetraspanin family; Region: Tetraspannin; pfam00335 347495009887 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 347495009888 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 347495009889 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 347495009890 YlzJ-like protein; Region: YlzJ; pfam14035 347495009891 Clp protease; Region: CLP_protease; pfam00574 347495009892 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 347495009893 active site 347495009894 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 347495009895 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495009896 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 347495009897 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 347495009898 dihydrodipicolinate synthase; Region: dapA; TIGR00674 347495009899 dimer interface [polypeptide binding]; other site 347495009900 active site 347495009901 catalytic residue [active] 347495009902 aspartate kinase I; Reviewed; Region: PRK08210 347495009903 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 347495009904 nucleotide binding site [chemical binding]; other site 347495009905 substrate binding site [chemical binding]; other site 347495009906 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 347495009907 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 347495009908 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 347495009909 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 347495009910 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 347495009911 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 347495009912 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 347495009913 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 347495009914 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 347495009915 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 347495009916 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 347495009917 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 347495009918 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 347495009919 NodB motif; other site 347495009920 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 347495009921 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 347495009922 RNase E interface [polypeptide binding]; other site 347495009923 trimer interface [polypeptide binding]; other site 347495009924 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 347495009925 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 347495009926 RNase E interface [polypeptide binding]; other site 347495009927 trimer interface [polypeptide binding]; other site 347495009928 active site 347495009929 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 347495009930 putative nucleic acid binding region [nucleotide binding]; other site 347495009931 G-X-X-G motif; other site 347495009932 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 347495009933 RNA binding site [nucleotide binding]; other site 347495009934 domain interface; other site 347495009935 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 347495009936 16S/18S rRNA binding site [nucleotide binding]; other site 347495009937 S13e-L30e interaction site [polypeptide binding]; other site 347495009938 25S rRNA binding site [nucleotide binding]; other site 347495009939 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 347495009940 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 347495009941 active site 347495009942 Riboflavin kinase; Region: Flavokinase; smart00904 347495009943 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 347495009944 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 347495009945 RNA binding site [nucleotide binding]; other site 347495009946 active site 347495009947 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 347495009948 Protein of unknown function (DUF503); Region: DUF503; pfam04456 347495009949 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 347495009950 translation initiation factor IF-2; Region: IF-2; TIGR00487 347495009951 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 347495009952 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 347495009953 G1 box; other site 347495009954 putative GEF interaction site [polypeptide binding]; other site 347495009955 GTP/Mg2+ binding site [chemical binding]; other site 347495009956 Switch I region; other site 347495009957 G2 box; other site 347495009958 G3 box; other site 347495009959 Switch II region; other site 347495009960 G4 box; other site 347495009961 G5 box; other site 347495009962 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 347495009963 Translation-initiation factor 2; Region: IF-2; pfam11987 347495009964 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 347495009965 hypothetical protein; Provisional; Region: PRK07714 347495009966 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 347495009967 putative RNA binding cleft [nucleotide binding]; other site 347495009968 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 347495009969 NusA N-terminal domain; Region: NusA_N; pfam08529 347495009970 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 347495009971 RNA binding site [nucleotide binding]; other site 347495009972 homodimer interface [polypeptide binding]; other site 347495009973 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 347495009974 G-X-X-G motif; other site 347495009975 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 347495009976 G-X-X-G motif; other site 347495009977 ribosome maturation protein RimP; Reviewed; Region: PRK00092 347495009978 Sm and related proteins; Region: Sm_like; cl00259 347495009979 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 347495009980 putative oligomer interface [polypeptide binding]; other site 347495009981 putative RNA binding site [nucleotide binding]; other site 347495009982 DNA polymerase III PolC; Validated; Region: polC; PRK00448 347495009983 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 347495009984 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 347495009985 putative active site [active] 347495009986 putative NTP binding site [chemical binding]; other site 347495009987 putative nucleic acid binding site [nucleotide binding]; other site 347495009988 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 347495009989 active site 347495009990 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 347495009991 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 347495009992 generic binding surface II; other site 347495009993 generic binding surface I; other site 347495009994 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 347495009995 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 347495009996 active site 347495009997 exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573 347495009998 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 347495009999 active site 347495010000 catalytic site [active] 347495010001 substrate binding site [chemical binding]; other site 347495010002 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 347495010003 prolyl-tRNA synthetase; Provisional; Region: PRK09194 347495010004 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 347495010005 dimer interface [polypeptide binding]; other site 347495010006 motif 1; other site 347495010007 active site 347495010008 motif 2; other site 347495010009 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 347495010010 putative deacylase active site [active] 347495010011 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 347495010012 active site 347495010013 motif 3; other site 347495010014 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 347495010015 anticodon binding site; other site 347495010016 RIP metalloprotease RseP; Region: TIGR00054 347495010017 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 347495010018 active site 347495010019 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 347495010020 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 347495010021 protein binding site [polypeptide binding]; other site 347495010022 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 347495010023 putative substrate binding region [chemical binding]; other site 347495010024 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 347495010025 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 347495010026 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 347495010027 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 347495010028 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 347495010029 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 347495010030 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 347495010031 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 347495010032 catalytic residue [active] 347495010033 putative FPP diphosphate binding site; other site 347495010034 putative FPP binding hydrophobic cleft; other site 347495010035 dimer interface [polypeptide binding]; other site 347495010036 putative IPP diphosphate binding site; other site 347495010037 ribosome recycling factor; Reviewed; Region: frr; PRK00083 347495010038 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 347495010039 hinge region; other site 347495010040 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 347495010041 putative nucleotide binding site [chemical binding]; other site 347495010042 uridine monophosphate binding site [chemical binding]; other site 347495010043 homohexameric interface [polypeptide binding]; other site 347495010044 elongation factor Ts; Provisional; Region: tsf; PRK09377 347495010045 UBA/TS-N domain; Region: UBA; pfam00627 347495010046 Elongation factor TS; Region: EF_TS; pfam00889 347495010047 Elongation factor TS; Region: EF_TS; pfam00889 347495010048 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 347495010049 rRNA interaction site [nucleotide binding]; other site 347495010050 S8 interaction site; other site 347495010051 putative laminin-1 binding site; other site 347495010052 transcriptional repressor CodY; Validated; Region: PRK04158 347495010053 CodY GAF-like domain; Region: CodY; pfam06018 347495010054 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 347495010055 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 347495010056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495010057 Walker A motif; other site 347495010058 ATP binding site [chemical binding]; other site 347495010059 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 347495010060 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 347495010061 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 347495010062 active site 347495010063 HslU subunit interaction site [polypeptide binding]; other site 347495010064 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 347495010065 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 347495010066 active site 347495010067 Int/Topo IB signature motif; other site 347495010068 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 347495010069 Glucose inhibited division protein A; Region: GIDA; pfam01134 347495010070 DNA topoisomerase I; Validated; Region: PRK05582 347495010071 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 347495010072 active site 347495010073 interdomain interaction site; other site 347495010074 putative metal-binding site [ion binding]; other site 347495010075 nucleotide binding site [chemical binding]; other site 347495010076 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 347495010077 domain I; other site 347495010078 DNA binding groove [nucleotide binding] 347495010079 phosphate binding site [ion binding]; other site 347495010080 domain II; other site 347495010081 domain III; other site 347495010082 nucleotide binding site [chemical binding]; other site 347495010083 catalytic site [active] 347495010084 domain IV; other site 347495010085 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 347495010086 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 347495010087 DNA protecting protein DprA; Region: dprA; TIGR00732 347495010088 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 347495010089 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 347495010090 CoA binding domain; Region: CoA_binding; smart00881 347495010091 CoA-ligase; Region: Ligase_CoA; pfam00549 347495010092 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 347495010093 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 347495010094 CoA-ligase; Region: Ligase_CoA; pfam00549 347495010095 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 347495010096 RNA/DNA hybrid binding site [nucleotide binding]; other site 347495010097 active site 347495010098 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 347495010099 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 347495010100 GTP/Mg2+ binding site [chemical binding]; other site 347495010101 G4 box; other site 347495010102 G5 box; other site 347495010103 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 347495010104 G1 box; other site 347495010105 G1 box; other site 347495010106 GTP/Mg2+ binding site [chemical binding]; other site 347495010107 Switch I region; other site 347495010108 G2 box; other site 347495010109 G2 box; other site 347495010110 G3 box; other site 347495010111 G3 box; other site 347495010112 Switch II region; other site 347495010113 Switch II region; other site 347495010114 G4 box; other site 347495010115 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 347495010116 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495010117 Catalytic site [active] 347495010118 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 347495010119 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 347495010120 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 347495010121 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 347495010122 RimM N-terminal domain; Region: RimM; pfam01782 347495010123 PRC-barrel domain; Region: PRC; pfam05239 347495010124 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 347495010125 signal recognition particle protein; Provisional; Region: PRK10867 347495010126 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 347495010127 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 347495010128 P loop; other site 347495010129 GTP binding site [chemical binding]; other site 347495010130 Signal peptide binding domain; Region: SRP_SPB; pfam02978 347495010131 putative DNA-binding protein; Validated; Region: PRK00118 347495010132 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 347495010133 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 347495010134 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 347495010135 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 347495010136 P loop; other site 347495010137 GTP binding site [chemical binding]; other site 347495010138 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 347495010139 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 347495010140 Walker A/P-loop; other site 347495010141 ATP binding site [chemical binding]; other site 347495010142 Q-loop/lid; other site 347495010143 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 347495010144 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 347495010145 ABC transporter signature motif; other site 347495010146 Walker B; other site 347495010147 D-loop; other site 347495010148 H-loop/switch region; other site 347495010149 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 347495010150 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 347495010151 dimerization interface [polypeptide binding]; other site 347495010152 active site 347495010153 metal binding site [ion binding]; metal-binding site 347495010154 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 347495010155 dsRNA binding site [nucleotide binding]; other site 347495010156 acyl carrier protein; Provisional; Region: acpP; PRK00982 347495010157 potential frameshift: common BLAST hit: gi|222097296|ref|YP_002531353.1| 3-ketoacyl-ACP reductase 347495010158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495010159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495010160 NAD(P) binding site [chemical binding]; other site 347495010161 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 347495010162 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 347495010163 putative phosphate acyltransferase; Provisional; Region: PRK05331 347495010164 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 347495010165 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 347495010166 active site 2 [active] 347495010167 active site 1 [active] 347495010168 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 347495010169 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 347495010170 generic binding surface II; other site 347495010171 ssDNA binding site; other site 347495010172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495010173 ATP binding site [chemical binding]; other site 347495010174 putative Mg++ binding site [ion binding]; other site 347495010175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495010176 nucleotide binding region [chemical binding]; other site 347495010177 ATP-binding site [chemical binding]; other site 347495010178 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 347495010179 DAK2 domain; Region: Dak2; pfam02734 347495010180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 347495010181 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 347495010182 Thiamine pyrophosphokinase; Region: TPK; cd07995 347495010183 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 347495010184 active site 347495010185 dimerization interface [polypeptide binding]; other site 347495010186 thiamine binding site [chemical binding]; other site 347495010187 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 347495010188 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 347495010189 substrate binding site [chemical binding]; other site 347495010190 hexamer interface [polypeptide binding]; other site 347495010191 metal binding site [ion binding]; metal-binding site 347495010192 GTPase RsgA; Reviewed; Region: PRK00098 347495010193 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 347495010194 RNA binding site [nucleotide binding]; other site 347495010195 homodimer interface [polypeptide binding]; other site 347495010196 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 347495010197 GTPase/Zn-binding domain interface [polypeptide binding]; other site 347495010198 GTP/Mg2+ binding site [chemical binding]; other site 347495010199 G4 box; other site 347495010200 G5 box; other site 347495010201 G1 box; other site 347495010202 Switch I region; other site 347495010203 G2 box; other site 347495010204 G3 box; other site 347495010205 Switch II region; other site 347495010206 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 347495010207 Catalytic domain of Protein Kinases; Region: PKc; cd00180 347495010208 active site 347495010209 ATP binding site [chemical binding]; other site 347495010210 substrate binding site [chemical binding]; other site 347495010211 activation loop (A-loop); other site 347495010212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 347495010213 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 347495010214 PASTA domain; Region: PASTA; pfam03793 347495010215 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 347495010216 Protein phosphatase 2C; Region: PP2C; pfam00481 347495010217 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 347495010218 active site 347495010219 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 347495010220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495010221 FeS/SAM binding site; other site 347495010222 16S rRNA methyltransferase B; Provisional; Region: PRK14902 347495010223 NusB family; Region: NusB; pfam01029 347495010224 putative RNA binding site [nucleotide binding]; other site 347495010225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495010226 S-adenosylmethionine binding site [chemical binding]; other site 347495010227 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 347495010228 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 347495010229 putative active site [active] 347495010230 substrate binding site [chemical binding]; other site 347495010231 putative cosubstrate binding site; other site 347495010232 catalytic site [active] 347495010233 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 347495010234 substrate binding site [chemical binding]; other site 347495010235 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 347495010236 active site 347495010237 catalytic residues [active] 347495010238 metal binding site [ion binding]; metal-binding site 347495010239 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495010240 primosomal protein N' Region: priA; TIGR00595 347495010241 ATP binding site [chemical binding]; other site 347495010242 putative Mg++ binding site [ion binding]; other site 347495010243 helicase superfamily c-terminal domain; Region: HELICc; smart00490 347495010244 nucleotide binding region [chemical binding]; other site 347495010245 ATP-binding site [chemical binding]; other site 347495010246 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 347495010247 Flavoprotein; Region: Flavoprotein; pfam02441 347495010248 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 347495010249 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 347495010250 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 347495010251 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 347495010252 catalytic site [active] 347495010253 G-X2-G-X-G-K; other site 347495010254 hypothetical protein; Provisional; Region: PRK04323 347495010255 hypothetical protein; Provisional; Region: PRK11820 347495010256 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 347495010257 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 347495010258 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 347495010259 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 347495010260 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 347495010261 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 347495010262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495010263 motif II; other site 347495010264 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 347495010265 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 347495010266 Domain of unknown function (DUF814); Region: DUF814; pfam05670 347495010267 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 347495010268 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 347495010269 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 347495010270 active site 347495010271 Protein of unknown function (DUF664); Region: DUF664; pfam04978 347495010272 DinB superfamily; Region: DinB_2; pfam12867 347495010273 YoqO-like protein; Region: YoqO; pfam14037 347495010274 YoqO-like protein; Region: YoqO; pfam14037 347495010275 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 347495010276 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 347495010277 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 347495010278 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495010279 motif II; other site 347495010280 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495010281 active site 347495010282 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 347495010283 active site 347495010284 dimer interface [polypeptide binding]; other site 347495010285 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 347495010286 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 347495010287 heterodimer interface [polypeptide binding]; other site 347495010288 active site 347495010289 FMN binding site [chemical binding]; other site 347495010290 homodimer interface [polypeptide binding]; other site 347495010291 substrate binding site [chemical binding]; other site 347495010292 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 347495010293 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 347495010294 FAD binding pocket [chemical binding]; other site 347495010295 FAD binding motif [chemical binding]; other site 347495010296 phosphate binding motif [ion binding]; other site 347495010297 beta-alpha-beta structure motif; other site 347495010298 NAD binding pocket [chemical binding]; other site 347495010299 Iron coordination center [ion binding]; other site 347495010300 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 347495010301 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 347495010302 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 347495010303 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 347495010304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 347495010305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 347495010306 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 347495010307 IMP binding site; other site 347495010308 dimer interface [polypeptide binding]; other site 347495010309 interdomain contacts; other site 347495010310 partial ornithine binding site; other site 347495010311 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 347495010312 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 347495010313 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 347495010314 catalytic site [active] 347495010315 subunit interface [polypeptide binding]; other site 347495010316 dihydroorotase; Validated; Region: pyrC; PRK09357 347495010317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 347495010318 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 347495010319 active site 347495010320 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 347495010321 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 347495010322 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 347495010323 uracil transporter; Provisional; Region: PRK10720 347495010324 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 347495010325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495010326 active site 347495010327 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 347495010328 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495010329 RNA binding surface [nucleotide binding]; other site 347495010330 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 347495010331 active site 347495010332 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 347495010333 lipoprotein signal peptidase; Provisional; Region: PRK14787 347495010334 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 347495010335 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 347495010336 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 347495010337 active site 347495010338 HIGH motif; other site 347495010339 nucleotide binding site [chemical binding]; other site 347495010340 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 347495010341 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 347495010342 active site 347495010343 KMSKS motif; other site 347495010344 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 347495010345 tRNA binding surface [nucleotide binding]; other site 347495010346 anticodon binding site; other site 347495010347 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 347495010348 DivIVA protein; Region: DivIVA; pfam05103 347495010349 DivIVA domain; Region: DivI1A_domain; TIGR03544 347495010350 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 347495010351 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 347495010352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495010353 RNA binding surface [nucleotide binding]; other site 347495010354 YGGT family; Region: YGGT; pfam02325 347495010355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 347495010356 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 347495010357 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 347495010358 catalytic residue [active] 347495010359 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 347495010360 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 347495010361 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 347495010362 sporulation sigma factor SigG; Reviewed; Region: PRK08215 347495010363 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495010364 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495010365 DNA binding residues [nucleotide binding] 347495010366 sporulation sigma factor SigE; Reviewed; Region: PRK08301 347495010367 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495010368 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495010369 DNA binding residues [nucleotide binding] 347495010370 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 347495010371 cell division protein FtsZ; Validated; Region: PRK09330 347495010372 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 347495010373 nucleotide binding site [chemical binding]; other site 347495010374 SulA interaction site; other site 347495010375 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 347495010376 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 347495010377 nucleotide binding site [chemical binding]; other site 347495010378 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 347495010379 Cell division protein FtsA; Region: FtsA; pfam14450 347495010380 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 347495010381 Cell division protein FtsQ; Region: FtsQ; pfam03799 347495010382 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 347495010383 FAD binding domain; Region: FAD_binding_4; pfam01565 347495010384 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 347495010385 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 347495010386 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 347495010387 active site 347495010388 homodimer interface [polypeptide binding]; other site 347495010389 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 347495010390 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 347495010391 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 347495010392 NAD binding site [chemical binding]; other site 347495010393 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 347495010394 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 347495010395 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 347495010396 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 347495010397 Mg++ binding site [ion binding]; other site 347495010398 putative catalytic motif [active] 347495010399 putative substrate binding site [chemical binding]; other site 347495010400 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 347495010401 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 347495010402 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 347495010403 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 347495010404 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 347495010405 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495010406 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495010407 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 347495010408 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 347495010409 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495010410 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495010411 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 347495010412 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 347495010413 Cell division protein FtsL; Region: FtsL; cl11433 347495010414 MraW methylase family; Region: Methyltransf_5; pfam01795 347495010415 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 347495010416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 347495010417 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 347495010418 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 347495010419 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 347495010420 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 347495010421 hypothetical protein; Provisional; Region: PRK13688 347495010422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495010423 Coenzyme A binding pocket [chemical binding]; other site 347495010424 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 347495010425 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 347495010426 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 347495010427 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 347495010428 hypothetical protein; Provisional; Region: PRK13670 347495010429 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 347495010430 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 347495010431 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 347495010432 protein binding site [polypeptide binding]; other site 347495010433 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 347495010434 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 347495010435 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 347495010436 active site 347495010437 nucleophile elbow; other site 347495010438 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 347495010439 Nucleoside recognition; Region: Gate; pfam07670 347495010440 Nucleoside recognition; Region: Gate; pfam07670 347495010441 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 347495010442 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 347495010443 active site 347495010444 (T/H)XGH motif; other site 347495010445 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 347495010446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495010447 S-adenosylmethionine binding site [chemical binding]; other site 347495010448 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 347495010449 Protein of unknown function (DUF964); Region: DUF964; pfam06133 347495010450 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495010451 catalytic core [active] 347495010452 YlbE-like protein; Region: YlbE; pfam14003 347495010453 Putative coat protein; Region: YlbD_coat; pfam14071 347495010454 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 347495010455 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 347495010456 YugN-like family; Region: YugN; pfam08868 347495010457 formamidase; Provisional; Region: amiF; PRK13287 347495010458 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 347495010459 multimer interface [polypeptide binding]; other site 347495010460 active site 347495010461 catalytic triad [active] 347495010462 dimer interface [polypeptide binding]; other site 347495010463 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 347495010464 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 347495010465 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 347495010466 Subunit I/III interface [polypeptide binding]; other site 347495010467 Subunit III/IV interface [polypeptide binding]; other site 347495010468 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 347495010469 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 347495010470 D-pathway; other site 347495010471 Putative ubiquinol binding site [chemical binding]; other site 347495010472 Low-spin heme (heme b) binding site [chemical binding]; other site 347495010473 Putative water exit pathway; other site 347495010474 Binuclear center (heme o3/CuB) [ion binding]; other site 347495010475 K-pathway; other site 347495010476 Putative proton exit pathway; other site 347495010477 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 347495010478 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 347495010479 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 347495010480 Cytochrome c; Region: Cytochrom_C; pfam00034 347495010481 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 347495010482 UbiA prenyltransferase family; Region: UbiA; pfam01040 347495010483 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 347495010484 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 347495010485 pyruvate carboxylase; Reviewed; Region: PRK12999 347495010486 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 347495010487 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 347495010488 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 347495010489 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 347495010490 active site 347495010491 catalytic residues [active] 347495010492 metal binding site [ion binding]; metal-binding site 347495010493 homodimer binding site [polypeptide binding]; other site 347495010494 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 347495010495 carboxyltransferase (CT) interaction site; other site 347495010496 biotinylation site [posttranslational modification]; other site 347495010497 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 347495010498 hypothetical protein; Provisional; Region: PRK13666 347495010499 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 347495010500 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 347495010501 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 347495010502 putative active site [active] 347495010503 PhoH-like protein; Region: PhoH; pfam02562 347495010504 hypothetical protein; Provisional; Region: PRK06733 347495010505 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 347495010506 YlaH-like protein; Region: YlaH; pfam14036 347495010507 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 347495010508 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 347495010509 G1 box; other site 347495010510 putative GEF interaction site [polypeptide binding]; other site 347495010511 GTP/Mg2+ binding site [chemical binding]; other site 347495010512 Switch I region; other site 347495010513 G2 box; other site 347495010514 G3 box; other site 347495010515 Switch II region; other site 347495010516 G4 box; other site 347495010517 G5 box; other site 347495010518 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 347495010519 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 347495010520 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 347495010521 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 347495010522 active site 347495010523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 347495010524 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 347495010525 hypothetical protein; Provisional; Region: PRK04387 347495010526 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 347495010527 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 347495010528 homodimer interface [polypeptide binding]; other site 347495010529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495010530 catalytic residue [active] 347495010531 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 347495010532 transglutaminase; Provisional; Region: tgl; PRK03187 347495010533 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 347495010534 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 347495010535 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 347495010536 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 347495010537 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 347495010538 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 347495010539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495010540 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 347495010541 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 347495010542 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 347495010543 E3 interaction surface; other site 347495010544 lipoyl attachment site [posttranslational modification]; other site 347495010545 e3 binding domain; Region: E3_binding; pfam02817 347495010546 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 347495010547 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 347495010548 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 347495010549 alpha subunit interface [polypeptide binding]; other site 347495010550 TPP binding site [chemical binding]; other site 347495010551 heterodimer interface [polypeptide binding]; other site 347495010552 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495010553 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 347495010554 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 347495010555 TPP-binding site [chemical binding]; other site 347495010556 heterodimer interface [polypeptide binding]; other site 347495010557 tetramer interface [polypeptide binding]; other site 347495010558 phosphorylation loop region [posttranslational modification] 347495010559 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 347495010560 active site 347495010561 catalytic residues [active] 347495010562 metal binding site [ion binding]; metal-binding site 347495010563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495010564 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495010565 active site 347495010566 motif I; other site 347495010567 motif II; other site 347495010568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495010569 hypothetical protein; Provisional; Region: PRK13667 347495010570 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 347495010571 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495010572 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 347495010573 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 347495010574 TrkA-N domain; Region: TrkA_N; pfam02254 347495010575 TrkA-C domain; Region: TrkA_C; pfam02080 347495010576 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 347495010577 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 347495010578 metal binding site [ion binding]; metal-binding site 347495010579 putative dimer interface [polypeptide binding]; other site 347495010580 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 347495010581 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 347495010582 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 347495010583 trimer interface [polypeptide binding]; other site 347495010584 active site 347495010585 substrate binding site [chemical binding]; other site 347495010586 CoA binding site [chemical binding]; other site 347495010587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495010588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495010589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495010590 dimerization interface [polypeptide binding]; other site 347495010591 FOG: CBS domain [General function prediction only]; Region: COG0517 347495010592 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 347495010593 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 347495010594 Protein of unknown function (DUF458); Region: DUF458; pfam04308 347495010595 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 347495010596 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 347495010597 catalytic residues [active] 347495010598 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 347495010599 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495010600 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 347495010601 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 347495010602 short chain dehydrogenase; Provisional; Region: PRK07677 347495010603 NAD(P) binding site [chemical binding]; other site 347495010604 substrate binding site [chemical binding]; other site 347495010605 homotetramer interface [polypeptide binding]; other site 347495010606 active site 347495010607 homodimer interface [polypeptide binding]; other site 347495010608 phosphodiesterase YaeI; Provisional; Region: PRK11340 347495010609 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 347495010610 putative active site [active] 347495010611 putative metal binding site [ion binding]; other site 347495010612 polyphosphate kinase; Provisional; Region: PRK05443 347495010613 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 347495010614 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 347495010615 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 347495010616 putative domain interface [polypeptide binding]; other site 347495010617 putative active site [active] 347495010618 catalytic site [active] 347495010619 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 347495010620 putative domain interface [polypeptide binding]; other site 347495010621 putative active site [active] 347495010622 catalytic site [active] 347495010623 exopolyphosphatase; Region: exo_poly_only; TIGR03706 347495010624 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 347495010625 nucleotide binding site [chemical binding]; other site 347495010626 YkyB-like protein; Region: YkyB; pfam14177 347495010627 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 347495010628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495010629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495010630 I-site; other site 347495010631 active site 347495010632 metal binding site [ion binding]; metal-binding site 347495010633 Phage lysis protein, holin; Region: Phage_holin; cl04675 347495010634 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495010635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495010636 putative substrate translocation pore; other site 347495010637 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495010638 Transcriptional regulator PadR-like family; Region: PadR; cl17335 347495010639 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 347495010640 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 347495010641 THF binding site; other site 347495010642 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 347495010643 substrate binding site [chemical binding]; other site 347495010644 THF binding site; other site 347495010645 zinc-binding site [ion binding]; other site 347495010646 Competence protein J (ComJ); Region: ComJ; pfam11033 347495010647 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 347495010648 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 347495010649 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495010650 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495010651 dimer interface [polypeptide binding]; other site 347495010652 phosphorylation site [posttranslational modification] 347495010653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495010654 ATP binding site [chemical binding]; other site 347495010655 Mg2+ binding site [ion binding]; other site 347495010656 G-X-G motif; other site 347495010657 aminotransferase A; Validated; Region: PRK07683 347495010658 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495010659 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495010660 homodimer interface [polypeptide binding]; other site 347495010661 catalytic residue [active] 347495010662 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495010663 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495010664 DNA binding site [nucleotide binding] 347495010665 domain linker motif; other site 347495010666 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 347495010667 putative dimerization interface [polypeptide binding]; other site 347495010668 putative ligand binding site [chemical binding]; other site 347495010669 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 347495010670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495010671 dimer interface [polypeptide binding]; other site 347495010672 conserved gate region; other site 347495010673 putative PBP binding loops; other site 347495010674 ABC-ATPase subunit interface; other site 347495010675 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 347495010676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495010677 dimer interface [polypeptide binding]; other site 347495010678 conserved gate region; other site 347495010679 putative PBP binding loops; other site 347495010680 ABC-ATPase subunit interface; other site 347495010681 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 347495010682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 347495010683 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 347495010684 homodimer interface [polypeptide binding]; other site 347495010685 maltodextrin glucosidase; Provisional; Region: PRK10785 347495010686 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 347495010687 active site 347495010688 homodimer interface [polypeptide binding]; other site 347495010689 catalytic site [active] 347495010690 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 347495010691 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 347495010692 Ca binding site [ion binding]; other site 347495010693 active site 347495010694 catalytic site [active] 347495010695 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 347495010696 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 347495010697 Walker A/P-loop; other site 347495010698 ATP binding site [chemical binding]; other site 347495010699 Q-loop/lid; other site 347495010700 ABC transporter signature motif; other site 347495010701 Walker B; other site 347495010702 D-loop; other site 347495010703 H-loop/switch region; other site 347495010704 TOBE domain; Region: TOBE_2; pfam08402 347495010705 hypothetical protein; Provisional; Region: PRK06720 347495010706 NAD(P) binding site [chemical binding]; other site 347495010707 RDD family; Region: RDD; pfam06271 347495010708 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 347495010709 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 347495010710 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 347495010711 Predicted ATPase [General function prediction only]; Region: COG3910 347495010712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495010713 Walker A/P-loop; other site 347495010714 ATP binding site [chemical binding]; other site 347495010715 Q-loop/lid; other site 347495010716 ABC transporter signature motif; other site 347495010717 Walker B; other site 347495010718 D-loop; other site 347495010719 H-loop/switch region; other site 347495010720 putative acyltransferase; Provisional; Region: PRK05790 347495010721 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 347495010722 dimer interface [polypeptide binding]; other site 347495010723 active site 347495010724 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 347495010725 nudix motif; other site 347495010726 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 347495010727 hypothetical protein; Validated; Region: PRK07668 347495010728 hypothetical protein; Validated; Region: PRK07668 347495010729 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495010730 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495010731 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 347495010732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495010733 NAD(P) binding site [chemical binding]; other site 347495010734 active site 347495010735 YvrJ protein family; Region: YvrJ; pfam12841 347495010736 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 347495010737 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 347495010738 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 347495010739 Phosphotransferase enzyme family; Region: APH; pfam01636 347495010740 Predicted amidohydrolase [General function prediction only]; Region: COG0388 347495010741 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 347495010742 putative active site [active] 347495010743 catalytic triad [active] 347495010744 putative dimer interface [polypeptide binding]; other site 347495010745 transaminase; Reviewed; Region: PRK08068 347495010746 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495010747 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495010748 homodimer interface [polypeptide binding]; other site 347495010749 catalytic residue [active] 347495010750 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: salvage_mtnW; TIGR03332 347495010751 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 347495010752 dimer interface [polypeptide binding]; other site 347495010753 active site 347495010754 catalytic residue [active] 347495010755 metal binding site [ion binding]; metal-binding site 347495010756 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 347495010757 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 347495010758 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 347495010759 intersubunit interface [polypeptide binding]; other site 347495010760 active site 347495010761 Zn2+ binding site [ion binding]; other site 347495010762 ARD/ARD' family; Region: ARD; pfam03079 347495010763 Cupin domain; Region: Cupin_2; pfam07883 347495010764 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 347495010765 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 347495010766 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 347495010767 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495010768 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495010769 metal binding site [ion binding]; metal-binding site 347495010770 active site 347495010771 I-site; other site 347495010772 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 347495010773 dimer interface [polypeptide binding]; other site 347495010774 FMN binding site [chemical binding]; other site 347495010775 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 347495010776 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 347495010777 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 347495010778 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 347495010779 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 347495010780 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 347495010781 dimerization domain swap beta strand [polypeptide binding]; other site 347495010782 regulatory protein interface [polypeptide binding]; other site 347495010783 active site 347495010784 regulatory phosphorylation site [posttranslational modification]; other site 347495010785 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 347495010786 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 347495010787 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 347495010788 active site turn [active] 347495010789 phosphorylation site [posttranslational modification] 347495010790 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 347495010791 HPr interaction site; other site 347495010792 glycerol kinase (GK) interaction site [polypeptide binding]; other site 347495010793 active site 347495010794 phosphorylation site [posttranslational modification] 347495010795 transcriptional antiterminator BglG; Provisional; Region: PRK09772 347495010796 CAT RNA binding domain; Region: CAT_RBD; smart01061 347495010797 PRD domain; Region: PRD; pfam00874 347495010798 PRD domain; Region: PRD; pfam00874 347495010799 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495010800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495010801 active site 347495010802 motif I; other site 347495010803 motif II; other site 347495010804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495010805 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 347495010806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495010807 DNA-binding site [nucleotide binding]; DNA binding site 347495010808 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 347495010809 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 347495010810 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 347495010811 active site 347495010812 trimer interface [polypeptide binding]; other site 347495010813 allosteric site; other site 347495010814 active site lid [active] 347495010815 hexamer (dimer of trimers) interface [polypeptide binding]; other site 347495010816 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 347495010817 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 347495010818 active site 347495010819 dimer interface [polypeptide binding]; other site 347495010820 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 347495010821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495010822 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 347495010823 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 347495010824 Domain of unknown function (DUF309); Region: DUF309; pfam03745 347495010825 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495010826 Coenzyme A binding pocket [chemical binding]; other site 347495010827 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 347495010828 active site 347495010829 Predicted secreted protein [Function unknown]; Region: COG4086 347495010830 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 347495010831 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495010832 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 347495010833 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 347495010834 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495010835 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 347495010836 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 347495010837 stage V sporulation protein AD; Validated; Region: PRK08304 347495010838 stage V sporulation protein AD; Provisional; Region: PRK12404 347495010839 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 347495010840 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 347495010841 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 347495010842 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 347495010843 Na2 binding site [ion binding]; other site 347495010844 putative substrate binding site 1 [chemical binding]; other site 347495010845 Na binding site 1 [ion binding]; other site 347495010846 putative substrate binding site 2 [chemical binding]; other site 347495010847 sporulation sigma factor SigF; Validated; Region: PRK05572 347495010848 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495010849 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 347495010850 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495010851 DNA binding residues [nucleotide binding] 347495010852 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 347495010853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495010854 ATP binding site [chemical binding]; other site 347495010855 Mg2+ binding site [ion binding]; other site 347495010856 G-X-G motif; other site 347495010857 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 347495010858 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 347495010859 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495010860 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 347495010861 Predicted transcriptional regulators [Transcription]; Region: COG1725 347495010862 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495010863 DNA-binding site [nucleotide binding]; DNA binding site 347495010864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495010865 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495010866 Walker A/P-loop; other site 347495010867 ATP binding site [chemical binding]; other site 347495010868 Q-loop/lid; other site 347495010869 ABC transporter signature motif; other site 347495010870 Walker B; other site 347495010871 D-loop; other site 347495010872 H-loop/switch region; other site 347495010873 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 347495010874 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495010875 MarR family; Region: MarR; pfam01047 347495010876 MarR family; Region: MarR_2; cl17246 347495010877 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 347495010878 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 347495010879 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 347495010880 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 347495010881 oligomer interface [polypeptide binding]; other site 347495010882 metal binding site [ion binding]; metal-binding site 347495010883 metal binding site [ion binding]; metal-binding site 347495010884 putative Cl binding site [ion binding]; other site 347495010885 aspartate ring; other site 347495010886 basic sphincter; other site 347495010887 hydrophobic gate; other site 347495010888 periplasmic entrance; other site 347495010889 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 347495010890 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 347495010891 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 347495010892 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 347495010893 purine nucleoside phosphorylase; Provisional; Region: PRK08202 347495010894 phosphopentomutase; Provisional; Region: PRK05362 347495010895 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 347495010896 YtkA-like; Region: YtkA; pfam13115 347495010897 YtkA-like; Region: YtkA; pfam13115 347495010898 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 347495010899 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 347495010900 active site 347495010901 Int/Topo IB signature motif; other site 347495010902 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 347495010903 ferric uptake regulator; Provisional; Region: fur; PRK09462 347495010904 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 347495010905 metal binding site 2 [ion binding]; metal-binding site 347495010906 putative DNA binding helix; other site 347495010907 metal binding site 1 [ion binding]; metal-binding site 347495010908 dimer interface [polypeptide binding]; other site 347495010909 structural Zn2+ binding site [ion binding]; other site 347495010910 stage II sporulation protein M; Region: spo_II_M; TIGR02831 347495010911 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495010912 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495010913 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 347495010914 dimer interface [polypeptide binding]; other site 347495010915 ADP-ribose binding site [chemical binding]; other site 347495010916 active site 347495010917 nudix motif; other site 347495010918 metal binding site [ion binding]; metal-binding site 347495010919 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 347495010920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 347495010921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 347495010922 active site 347495010923 catalytic tetrad [active] 347495010924 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 347495010925 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 347495010926 active site 347495010927 catalytic tetrad [active] 347495010928 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 347495010929 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 347495010930 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 347495010931 putative active site [active] 347495010932 putative metal binding site [ion binding]; other site 347495010933 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 347495010934 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 347495010935 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 347495010936 Predicted permease [General function prediction only]; Region: COG2056 347495010937 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 347495010938 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 347495010939 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495010940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495010941 DNA binding site [nucleotide binding] 347495010942 domain linker motif; other site 347495010943 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 347495010944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495010945 Coenzyme A binding pocket [chemical binding]; other site 347495010946 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 347495010947 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 347495010948 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 347495010949 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 347495010950 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 347495010951 catalytic motif [active] 347495010952 Zn binding site [ion binding]; other site 347495010953 RibD C-terminal domain; Region: RibD_C; cl17279 347495010954 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 347495010955 Lumazine binding domain; Region: Lum_binding; pfam00677 347495010956 Lumazine binding domain; Region: Lum_binding; pfam00677 347495010957 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 347495010958 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 347495010959 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 347495010960 dimerization interface [polypeptide binding]; other site 347495010961 active site 347495010962 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 347495010963 homopentamer interface [polypeptide binding]; other site 347495010964 active site 347495010965 biotin synthase; Validated; Region: PRK06256 347495010966 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495010967 FeS/SAM binding site; other site 347495010968 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 347495010969 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 347495010970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495010971 S-adenosylmethionine binding site [chemical binding]; other site 347495010972 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495010973 TAP-like protein; Region: Abhydrolase_4; pfam08386 347495010974 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 347495010975 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 347495010976 substrate-cofactor binding pocket; other site 347495010977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495010978 catalytic residue [active] 347495010979 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 347495010980 AAA domain; Region: AAA_26; pfam13500 347495010981 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 347495010982 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495010983 inhibitor-cofactor binding pocket; inhibition site 347495010984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495010985 catalytic residue [active] 347495010986 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 347495010987 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 347495010988 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 347495010989 active site 347495010990 metal binding site [ion binding]; metal-binding site 347495010991 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 347495010992 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 347495010993 active site 347495010994 catalytic triad [active] 347495010995 oxyanion hole [active] 347495010996 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495010997 dimerization interface [polypeptide binding]; other site 347495010998 putative DNA binding site [nucleotide binding]; other site 347495010999 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495011000 putative Zn2+ binding site [ion binding]; other site 347495011001 ornithine carbamoyltransferase; Provisional; Region: PRK00779 347495011002 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 347495011003 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 347495011004 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 347495011005 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495011006 inhibitor-cofactor binding pocket; inhibition site 347495011007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011008 catalytic residue [active] 347495011009 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 347495011010 nucleotide binding site [chemical binding]; other site 347495011011 N-acetyl-L-glutamate binding site [chemical binding]; other site 347495011012 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 347495011013 heterotetramer interface [polypeptide binding]; other site 347495011014 active site pocket [active] 347495011015 cleavage site 347495011016 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 347495011017 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 347495011018 YqzH-like protein; Region: YqzH; pfam14164 347495011019 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 347495011020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495011021 NAD(P) binding site [chemical binding]; other site 347495011022 active site 347495011023 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495011024 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 347495011025 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 347495011026 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 347495011027 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 347495011028 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 347495011029 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 347495011030 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 347495011031 putative L-serine binding site [chemical binding]; other site 347495011032 ribonuclease Z; Region: RNase_Z; TIGR02651 347495011033 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 347495011034 DNA polymerase IV; Validated; Region: PRK01810 347495011035 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 347495011036 active site 347495011037 DNA binding site [nucleotide binding] 347495011038 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 347495011039 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 347495011040 peptidase T-like protein; Region: PepT-like; TIGR01883 347495011041 metal binding site [ion binding]; metal-binding site 347495011042 putative dimer interface [polypeptide binding]; other site 347495011043 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495011044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495011045 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 347495011046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 347495011047 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 347495011048 Predicted membrane protein [Function unknown]; Region: COG4129 347495011049 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 347495011050 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 347495011051 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 347495011052 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 347495011053 Walker A/P-loop; other site 347495011054 ATP binding site [chemical binding]; other site 347495011055 Q-loop/lid; other site 347495011056 ABC transporter signature motif; other site 347495011057 Walker B; other site 347495011058 D-loop; other site 347495011059 H-loop/switch region; other site 347495011060 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 347495011061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495011062 dimer interface [polypeptide binding]; other site 347495011063 conserved gate region; other site 347495011064 putative PBP binding loops; other site 347495011065 ABC-ATPase subunit interface; other site 347495011066 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 347495011067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 347495011068 substrate binding pocket [chemical binding]; other site 347495011069 membrane-bound complex binding site; other site 347495011070 hinge residues; other site 347495011071 Disulphide isomerase; Region: Disulph_isomer; pfam06491 347495011072 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 347495011073 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 347495011074 nudix motif; other site 347495011075 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 347495011076 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 347495011077 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 347495011078 E3 interaction surface; other site 347495011079 lipoyl attachment site [posttranslational modification]; other site 347495011080 e3 binding domain; Region: E3_binding; pfam02817 347495011081 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 347495011082 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 347495011083 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 347495011084 alpha subunit interface [polypeptide binding]; other site 347495011085 TPP binding site [chemical binding]; other site 347495011086 heterodimer interface [polypeptide binding]; other site 347495011087 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495011088 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 347495011089 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 347495011090 tetramer interface [polypeptide binding]; other site 347495011091 TPP-binding site [chemical binding]; other site 347495011092 heterodimer interface [polypeptide binding]; other site 347495011093 phosphorylation loop region [posttranslational modification] 347495011094 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 347495011095 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 347495011096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495011097 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 347495011098 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 347495011099 nucleotide binding site [chemical binding]; other site 347495011100 Acetokinase family; Region: Acetate_kinase; cl17229 347495011101 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 347495011102 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 347495011103 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 347495011104 NAD binding site [chemical binding]; other site 347495011105 Phe binding site; other site 347495011106 phosphate butyryltransferase; Validated; Region: PRK07742 347495011107 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 347495011108 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495011109 putative active site [active] 347495011110 heme pocket [chemical binding]; other site 347495011111 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495011112 putative active site [active] 347495011113 heme pocket [chemical binding]; other site 347495011114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495011115 Walker A motif; other site 347495011116 ATP binding site [chemical binding]; other site 347495011117 Walker B motif; other site 347495011118 arginine finger; other site 347495011119 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 347495011120 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 347495011121 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 347495011122 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 347495011123 active site 347495011124 catalytic site [active] 347495011125 metal binding site [ion binding]; metal-binding site 347495011126 dimer interface [polypeptide binding]; other site 347495011127 YycC-like protein; Region: YycC; pfam14174 347495011128 conserved hypothetical integral membrane protein; Region: TIGR03766 347495011129 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 347495011130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495011131 active site 347495011132 phosphorylation site [posttranslational modification] 347495011133 intermolecular recognition site; other site 347495011134 dimerization interface [polypeptide binding]; other site 347495011135 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 347495011136 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 347495011137 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 347495011138 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 347495011139 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 347495011140 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 347495011141 Walker A/P-loop; other site 347495011142 ATP binding site [chemical binding]; other site 347495011143 Q-loop/lid; other site 347495011144 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 347495011145 ABC transporter signature motif; other site 347495011146 Walker B; other site 347495011147 D-loop; other site 347495011148 H-loop/switch region; other site 347495011149 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 347495011150 arginine repressor; Provisional; Region: PRK04280 347495011151 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 347495011152 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 347495011153 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495011154 RNA binding surface [nucleotide binding]; other site 347495011155 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 347495011156 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 347495011157 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 347495011158 TPP-binding site; other site 347495011159 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 347495011160 PYR/PP interface [polypeptide binding]; other site 347495011161 dimer interface [polypeptide binding]; other site 347495011162 TPP binding site [chemical binding]; other site 347495011163 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 347495011164 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 347495011165 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 347495011166 substrate binding pocket [chemical binding]; other site 347495011167 chain length determination region; other site 347495011168 substrate-Mg2+ binding site; other site 347495011169 catalytic residues [active] 347495011170 aspartate-rich region 1; other site 347495011171 active site lid residues [active] 347495011172 aspartate-rich region 2; other site 347495011173 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 347495011174 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 347495011175 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 347495011176 generic binding surface II; other site 347495011177 generic binding surface I; other site 347495011178 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 347495011179 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 347495011180 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 347495011181 homodimer interface [polypeptide binding]; other site 347495011182 NADP binding site [chemical binding]; other site 347495011183 substrate binding site [chemical binding]; other site 347495011184 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 347495011185 putative RNA binding site [nucleotide binding]; other site 347495011186 Asp23 family; Region: Asp23; pfam03780 347495011187 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 347495011188 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 347495011189 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 347495011190 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 347495011191 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 347495011192 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 347495011193 carboxyltransferase (CT) interaction site; other site 347495011194 biotinylation site [posttranslational modification]; other site 347495011195 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 347495011196 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 347495011197 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 347495011198 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 347495011199 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 347495011200 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 347495011201 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 347495011202 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 347495011203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495011204 Walker A motif; other site 347495011205 ATP binding site [chemical binding]; other site 347495011206 Walker B motif; other site 347495011207 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 347495011208 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495011209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495011210 elongation factor P; Validated; Region: PRK00529 347495011211 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 347495011212 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 347495011213 RNA binding site [nucleotide binding]; other site 347495011214 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 347495011215 RNA binding site [nucleotide binding]; other site 347495011216 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 347495011217 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 347495011218 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 347495011219 active site 347495011220 Dehydroquinase class II; Region: DHquinase_II; pfam01220 347495011221 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 347495011222 trimer interface [polypeptide binding]; other site 347495011223 active site 347495011224 dimer interface [polypeptide binding]; other site 347495011225 Conserved membrane protein YqhR; Region: YqhR; pfam11085 347495011226 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 347495011227 CCC1-related family of proteins; Region: CCC1_like; cl00278 347495011228 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 347495011229 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 347495011230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495011231 motif II; other site 347495011232 manganese transport transcriptional regulator; Provisional; Region: PRK03902 347495011233 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 347495011234 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 347495011235 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 347495011236 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495011237 FeS/SAM binding site; other site 347495011238 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495011239 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 347495011240 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 347495011241 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495011242 active site residue [active] 347495011243 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495011244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495011245 DNA binding site [nucleotide binding] 347495011246 domain linker motif; other site 347495011247 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 347495011248 putative dimerization interface [polypeptide binding]; other site 347495011249 putative ligand binding site [chemical binding]; other site 347495011250 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495011251 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495011252 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 347495011253 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 347495011254 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 347495011255 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 347495011256 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 347495011257 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 347495011258 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 347495011259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495011260 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495011261 Walker A/P-loop; other site 347495011262 ATP binding site [chemical binding]; other site 347495011263 Q-loop/lid; other site 347495011264 ABC transporter signature motif; other site 347495011265 Walker B; other site 347495011266 D-loop; other site 347495011267 H-loop/switch region; other site 347495011268 Predicted transcriptional regulators [Transcription]; Region: COG1725 347495011269 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495011270 DNA-binding site [nucleotide binding]; DNA binding site 347495011271 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 347495011272 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 347495011273 tetramer interface [polypeptide binding]; other site 347495011274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011275 catalytic residue [active] 347495011276 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 347495011277 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 347495011278 tetramer interface [polypeptide binding]; other site 347495011279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011280 catalytic residue [active] 347495011281 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 347495011282 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 347495011283 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 347495011284 DEAD-like helicases superfamily; Region: DEXDc; smart00487 347495011285 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495011286 ATP binding site [chemical binding]; other site 347495011287 putative Mg++ binding site [ion binding]; other site 347495011288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495011289 nucleotide binding region [chemical binding]; other site 347495011290 ATP-binding site [chemical binding]; other site 347495011291 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 347495011292 YqzE-like protein; Region: YqzE; pfam14038 347495011293 shikimate kinase; Reviewed; Region: aroK; PRK00131 347495011294 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 347495011295 ADP binding site [chemical binding]; other site 347495011296 magnesium binding site [ion binding]; other site 347495011297 putative shikimate binding site; other site 347495011298 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 347495011299 ComG operon protein 7; Region: ComGG; pfam14173 347495011300 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 347495011301 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 347495011302 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 347495011303 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 347495011304 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 347495011305 Type II/IV secretion system protein; Region: T2SE; pfam00437 347495011306 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 347495011307 Walker A motif; other site 347495011308 ATP binding site [chemical binding]; other site 347495011309 Walker B motif; other site 347495011310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495011311 putative DNA binding site [nucleotide binding]; other site 347495011312 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 347495011313 putative Zn2+ binding site [ion binding]; other site 347495011314 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 347495011315 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 347495011316 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 347495011317 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 347495011318 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 347495011319 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 347495011320 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 347495011321 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 347495011322 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 347495011323 active site 347495011324 homodimer interface [polypeptide binding]; other site 347495011325 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 347495011326 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 347495011327 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 347495011328 substrate binding pocket [chemical binding]; other site 347495011329 dimer interface [polypeptide binding]; other site 347495011330 inhibitor binding site; inhibition site 347495011331 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 347495011332 B12 binding site [chemical binding]; other site 347495011333 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 347495011334 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 347495011335 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 347495011336 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 347495011337 FAD binding site [chemical binding]; other site 347495011338 cystathionine gamma-synthase; Reviewed; Region: PRK08247 347495011339 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 347495011340 homodimer interface [polypeptide binding]; other site 347495011341 substrate-cofactor binding pocket; other site 347495011342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011343 catalytic residue [active] 347495011344 cystathionine beta-lyase; Provisional; Region: PRK08064 347495011345 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 347495011346 homodimer interface [polypeptide binding]; other site 347495011347 substrate-cofactor binding pocket; other site 347495011348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011349 catalytic residue [active] 347495011350 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495011351 dimerization interface [polypeptide binding]; other site 347495011352 putative DNA binding site [nucleotide binding]; other site 347495011353 putative Zn2+ binding site [ion binding]; other site 347495011354 Uncharacterized conserved protein [Function unknown]; Region: COG1565 347495011355 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 347495011356 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 347495011357 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 347495011358 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 347495011359 nucleotide binding site [chemical binding]; other site 347495011360 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 347495011361 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 347495011362 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 347495011363 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 347495011364 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 347495011365 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 347495011366 active site 347495011367 Substrate binding site; other site 347495011368 Mg++ binding site; other site 347495011369 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 347495011370 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 347495011371 active site 347495011372 metal binding site [ion binding]; metal-binding site 347495011373 substrate binding site [chemical binding]; other site 347495011374 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 347495011375 PhoU domain; Region: PhoU; pfam01895 347495011376 PhoU domain; Region: PhoU; pfam01895 347495011377 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 347495011378 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 347495011379 Walker A/P-loop; other site 347495011380 ATP binding site [chemical binding]; other site 347495011381 Q-loop/lid; other site 347495011382 ABC transporter signature motif; other site 347495011383 Walker B; other site 347495011384 D-loop; other site 347495011385 H-loop/switch region; other site 347495011386 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 347495011387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495011388 dimer interface [polypeptide binding]; other site 347495011389 conserved gate region; other site 347495011390 putative PBP binding loops; other site 347495011391 ABC-ATPase subunit interface; other site 347495011392 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 347495011393 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495011394 dimer interface [polypeptide binding]; other site 347495011395 conserved gate region; other site 347495011396 putative PBP binding loops; other site 347495011397 ABC-ATPase subunit interface; other site 347495011398 PBP superfamily domain; Region: PBP_like_2; cl17296 347495011399 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 347495011400 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495011401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495011402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495011403 putative substrate translocation pore; other site 347495011404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495011405 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 347495011406 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 347495011407 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 347495011408 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 347495011409 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 347495011410 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 347495011411 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 347495011412 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 347495011413 metal binding site 2 [ion binding]; metal-binding site 347495011414 putative DNA binding helix; other site 347495011415 metal binding site 1 [ion binding]; metal-binding site 347495011416 dimer interface [polypeptide binding]; other site 347495011417 structural Zn2+ binding site [ion binding]; other site 347495011418 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 347495011419 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495011420 ABC-ATPase subunit interface; other site 347495011421 dimer interface [polypeptide binding]; other site 347495011422 putative PBP binding regions; other site 347495011423 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 347495011424 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 347495011425 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495011426 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495011427 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495011428 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 347495011429 endonuclease IV; Provisional; Region: PRK01060 347495011430 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 347495011431 AP (apurinic/apyrimidinic) site pocket; other site 347495011432 DNA interaction; other site 347495011433 Metal-binding active site; metal-binding site 347495011434 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 347495011435 DEAD-like helicases superfamily; Region: DEXDc; smart00487 347495011436 ATP binding site [chemical binding]; other site 347495011437 Mg++ binding site [ion binding]; other site 347495011438 motif III; other site 347495011439 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495011440 nucleotide binding region [chemical binding]; other site 347495011441 ATP-binding site [chemical binding]; other site 347495011442 YqfQ-like protein; Region: YqfQ; pfam14181 347495011443 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 347495011444 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 347495011445 Uncharacterized conserved protein [Function unknown]; Region: COG0327 347495011446 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 347495011447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 347495011448 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 347495011449 Uncharacterized conserved protein [Function unknown]; Region: COG0327 347495011450 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 347495011451 Family of unknown function (DUF633); Region: DUF633; pfam04816 347495011452 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 347495011453 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 347495011454 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 347495011455 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 347495011456 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 347495011457 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495011458 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 347495011459 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495011460 DNA binding residues [nucleotide binding] 347495011461 DNA primase; Validated; Region: dnaG; PRK05667 347495011462 CHC2 zinc finger; Region: zf-CHC2; pfam01807 347495011463 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 347495011464 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 347495011465 active site 347495011466 metal binding site [ion binding]; metal-binding site 347495011467 interdomain interaction site; other site 347495011468 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 347495011469 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 347495011470 PEP synthetase regulatory protein; Provisional; Region: PRK05339 347495011471 HTH domain; Region: HTH_11; pfam08279 347495011472 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 347495011473 FOG: CBS domain [General function prediction only]; Region: COG0517 347495011474 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 347495011475 Recombination protein O N terminal; Region: RecO_N; pfam11967 347495011476 Recombination protein O C terminal; Region: RecO_C; pfam02565 347495011477 YqzL-like protein; Region: YqzL; pfam14006 347495011478 GTPase Era; Reviewed; Region: era; PRK00089 347495011479 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 347495011480 G1 box; other site 347495011481 GTP/Mg2+ binding site [chemical binding]; other site 347495011482 Switch I region; other site 347495011483 G2 box; other site 347495011484 Switch II region; other site 347495011485 G3 box; other site 347495011486 G4 box; other site 347495011487 G5 box; other site 347495011488 KH domain; Region: KH_2; pfam07650 347495011489 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 347495011490 active site 347495011491 catalytic motif [active] 347495011492 Zn binding site [ion binding]; other site 347495011493 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 347495011494 metal-binding heat shock protein; Provisional; Region: PRK00016 347495011495 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 347495011496 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 347495011497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495011498 Zn2+ binding site [ion binding]; other site 347495011499 Mg2+ binding site [ion binding]; other site 347495011500 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 347495011501 PhoH-like protein; Region: PhoH; pfam02562 347495011502 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 347495011503 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 347495011504 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 347495011505 Yqey-like protein; Region: YqeY; pfam09424 347495011506 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 347495011507 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 347495011508 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 347495011509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495011510 FeS/SAM binding site; other site 347495011511 TRAM domain; Region: TRAM; cl01282 347495011512 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 347495011513 RNA methyltransferase, RsmE family; Region: TIGR00046 347495011514 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 347495011515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495011516 S-adenosylmethionine binding site [chemical binding]; other site 347495011517 chaperone protein DnaJ; Provisional; Region: PRK14280 347495011518 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 347495011519 HSP70 interaction site [polypeptide binding]; other site 347495011520 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 347495011521 substrate binding site [polypeptide binding]; other site 347495011522 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 347495011523 Zn binding sites [ion binding]; other site 347495011524 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 347495011525 dimer interface [polypeptide binding]; other site 347495011526 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 347495011527 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 347495011528 nucleotide binding site [chemical binding]; other site 347495011529 NEF interaction site [polypeptide binding]; other site 347495011530 SBD interface [polypeptide binding]; other site 347495011531 GrpE; Region: GrpE; pfam01025 347495011532 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 347495011533 dimer interface [polypeptide binding]; other site 347495011534 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 347495011535 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 347495011536 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 347495011537 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 347495011538 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495011539 FeS/SAM binding site; other site 347495011540 HemN C-terminal domain; Region: HemN_C; pfam06969 347495011541 Predicted transcriptional regulators [Transcription]; Region: COG1733 347495011542 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 347495011543 GTP-binding protein LepA; Provisional; Region: PRK05433 347495011544 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 347495011545 G1 box; other site 347495011546 putative GEF interaction site [polypeptide binding]; other site 347495011547 GTP/Mg2+ binding site [chemical binding]; other site 347495011548 Switch I region; other site 347495011549 G2 box; other site 347495011550 G3 box; other site 347495011551 Switch II region; other site 347495011552 G4 box; other site 347495011553 G5 box; other site 347495011554 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 347495011555 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 347495011556 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 347495011557 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 347495011558 potential frameshift: common BLAST hit: gi|227817097|ref|YP_002817106.1| germination protease 347495011559 Germination protease; Region: Peptidase_A25; cl04057 347495011560 Germination protease; Region: Peptidase_A25; cl04057 347495011561 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 347495011562 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 347495011563 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 347495011564 YqzM-like protein; Region: YqzM; pfam14141 347495011565 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 347495011566 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 347495011567 Competence protein; Region: Competence; pfam03772 347495011568 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495011569 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 347495011570 catalytic motif [active] 347495011571 Zn binding site [ion binding]; other site 347495011572 SLBB domain; Region: SLBB; pfam10531 347495011573 comEA protein; Region: comE; TIGR01259 347495011574 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 347495011575 late competence protein ComER; Validated; Region: PRK07680 347495011576 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 347495011577 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 347495011578 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495011579 S-adenosylmethionine binding site [chemical binding]; other site 347495011580 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 347495011581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495011582 Zn2+ binding site [ion binding]; other site 347495011583 Mg2+ binding site [ion binding]; other site 347495011584 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 347495011585 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 347495011586 active site 347495011587 (T/H)XGH motif; other site 347495011588 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 347495011589 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 347495011590 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 347495011591 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 347495011592 shikimate binding site; other site 347495011593 NAD(P) binding site [chemical binding]; other site 347495011594 GTPase YqeH; Provisional; Region: PRK13796 347495011595 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 347495011596 GTP/Mg2+ binding site [chemical binding]; other site 347495011597 G4 box; other site 347495011598 G5 box; other site 347495011599 G1 box; other site 347495011600 Switch I region; other site 347495011601 G2 box; other site 347495011602 G3 box; other site 347495011603 Switch II region; other site 347495011604 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 347495011605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495011606 active site 347495011607 motif I; other site 347495011608 motif II; other site 347495011609 Sporulation inhibitor A; Region: Sda; pfam08970 347495011610 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 347495011611 sporulation sigma factor SigK; Reviewed; Region: PRK05803 347495011612 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495011613 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495011614 DNA binding residues [nucleotide binding] 347495011615 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 347495011616 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 347495011617 dimer interface [polypeptide binding]; other site 347495011618 FMN binding site [chemical binding]; other site 347495011619 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 347495011620 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 347495011621 synthetase active site [active] 347495011622 NTP binding site [chemical binding]; other site 347495011623 metal binding site [ion binding]; metal-binding site 347495011624 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 347495011625 dimer interface [polypeptide binding]; other site 347495011626 Alkaline phosphatase homologues; Region: alkPPc; smart00098 347495011627 active site 347495011628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495011629 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 347495011630 Coenzyme A binding pocket [chemical binding]; other site 347495011631 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 347495011632 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 347495011633 CHAT domain; Region: CHAT; cl17868 347495011634 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 347495011635 catalytic core [active] 347495011636 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 347495011637 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 347495011638 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 347495011639 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 347495011640 putative active site [active] 347495011641 catalytic triad [active] 347495011642 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 347495011643 putative integrin binding motif; other site 347495011644 PA/protease domain interface [polypeptide binding]; other site 347495011645 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 347495011646 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 347495011647 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 347495011648 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 347495011649 cofactor binding site; other site 347495011650 metal binding site [ion binding]; metal-binding site 347495011651 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 347495011652 aromatic arch; other site 347495011653 DCoH dimer interaction site [polypeptide binding]; other site 347495011654 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 347495011655 DCoH tetramer interaction site [polypeptide binding]; other site 347495011656 substrate binding site [chemical binding]; other site 347495011657 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 347495011658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 347495011659 putative metal binding site [ion binding]; other site 347495011660 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 347495011661 active site 347495011662 metal binding site [ion binding]; metal-binding site 347495011663 Predicted membrane protein [Function unknown]; Region: COG2259 347495011664 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 347495011665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495011666 non-specific DNA binding site [nucleotide binding]; other site 347495011667 salt bridge; other site 347495011668 sequence-specific DNA binding site [nucleotide binding]; other site 347495011669 Cupin domain; Region: Cupin_2; pfam07883 347495011670 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 347495011671 active site 2 [active] 347495011672 active site 1 [active] 347495011673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495011674 Coenzyme A binding pocket [chemical binding]; other site 347495011675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495011676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 347495011677 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 347495011678 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 347495011679 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 347495011680 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 347495011681 Walker A/P-loop; other site 347495011682 ATP binding site [chemical binding]; other site 347495011683 Q-loop/lid; other site 347495011684 ABC transporter signature motif; other site 347495011685 Walker B; other site 347495011686 D-loop; other site 347495011687 H-loop/switch region; other site 347495011688 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 347495011689 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495011690 ABC-ATPase subunit interface; other site 347495011691 dimer interface [polypeptide binding]; other site 347495011692 putative PBP binding regions; other site 347495011693 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495011694 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 347495011695 intersubunit interface [polypeptide binding]; other site 347495011696 YrhC-like protein; Region: YrhC; pfam14143 347495011697 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 347495011698 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 347495011699 putative catalytic cysteine [active] 347495011700 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 347495011701 putative active site [active] 347495011702 metal binding site [ion binding]; metal-binding site 347495011703 cystathionine beta-lyase; Provisional; Region: PRK07671 347495011704 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 347495011705 homodimer interface [polypeptide binding]; other site 347495011706 substrate-cofactor binding pocket; other site 347495011707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011708 catalytic residue [active] 347495011709 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 347495011710 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 347495011711 dimer interface [polypeptide binding]; other site 347495011712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495011713 catalytic residue [active] 347495011714 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 347495011715 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 347495011716 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495011717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495011718 S-adenosylmethionine binding site [chemical binding]; other site 347495011719 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 347495011720 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 347495011721 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 347495011722 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 347495011723 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495011724 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 347495011725 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 347495011726 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 347495011727 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 347495011728 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 347495011729 ATP-binding site [chemical binding]; other site 347495011730 Sugar specificity; other site 347495011731 Pyrimidine base specificity; other site 347495011732 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 347495011733 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 347495011734 Peptidase family U32; Region: Peptidase_U32; pfam01136 347495011735 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 347495011736 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 347495011737 Peptidase family U32; Region: Peptidase_U32; pfam01136 347495011738 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 347495011739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495011740 S-adenosylmethionine binding site [chemical binding]; other site 347495011741 YceG-like family; Region: YceG; pfam02618 347495011742 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 347495011743 dimerization interface [polypeptide binding]; other site 347495011744 hypothetical protein; Provisional; Region: PRK13678 347495011745 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 347495011746 hypothetical protein; Provisional; Region: PRK05473 347495011747 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 347495011748 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 347495011749 motif 1; other site 347495011750 active site 347495011751 motif 2; other site 347495011752 motif 3; other site 347495011753 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 347495011754 DHHA1 domain; Region: DHHA1; pfam02272 347495011755 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 347495011756 Domain of unknown function DUF20; Region: UPF0118; pfam01594 347495011757 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 347495011758 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 347495011759 AAA domain; Region: AAA_30; pfam13604 347495011760 Family description; Region: UvrD_C_2; pfam13538 347495011761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495011762 TPR motif; other site 347495011763 TPR repeat; Region: TPR_11; pfam13414 347495011764 binding surface 347495011765 TPR repeat; Region: TPR_11; pfam13414 347495011766 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495011767 binding surface 347495011768 TPR motif; other site 347495011769 TPR repeat; Region: TPR_11; pfam13414 347495011770 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 347495011771 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 347495011772 Ligand Binding Site [chemical binding]; other site 347495011773 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 347495011774 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 347495011775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495011776 catalytic residue [active] 347495011777 Predicted transcriptional regulator [Transcription]; Region: COG1959 347495011778 Transcriptional regulator; Region: Rrf2; pfam02082 347495011779 recombination factor protein RarA; Reviewed; Region: PRK13342 347495011780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495011781 Walker A motif; other site 347495011782 ATP binding site [chemical binding]; other site 347495011783 Walker B motif; other site 347495011784 arginine finger; other site 347495011785 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 347495011786 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 347495011787 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 347495011788 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 347495011789 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 347495011790 putative ATP binding site [chemical binding]; other site 347495011791 putative substrate interface [chemical binding]; other site 347495011792 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 347495011793 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 347495011794 dimer interface [polypeptide binding]; other site 347495011795 anticodon binding site; other site 347495011796 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 347495011797 homodimer interface [polypeptide binding]; other site 347495011798 motif 1; other site 347495011799 active site 347495011800 motif 2; other site 347495011801 GAD domain; Region: GAD; pfam02938 347495011802 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 347495011803 motif 3; other site 347495011804 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 347495011805 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 347495011806 dimer interface [polypeptide binding]; other site 347495011807 motif 1; other site 347495011808 active site 347495011809 motif 2; other site 347495011810 motif 3; other site 347495011811 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 347495011812 anticodon binding site; other site 347495011813 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 347495011814 putative active site [active] 347495011815 dimerization interface [polypeptide binding]; other site 347495011816 putative tRNAtyr binding site [nucleotide binding]; other site 347495011817 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 347495011818 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495011819 Zn2+ binding site [ion binding]; other site 347495011820 Mg2+ binding site [ion binding]; other site 347495011821 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 347495011822 synthetase active site [active] 347495011823 NTP binding site [chemical binding]; other site 347495011824 metal binding site [ion binding]; metal-binding site 347495011825 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 347495011826 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 347495011827 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495011828 active site 347495011829 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 347495011830 DHH family; Region: DHH; pfam01368 347495011831 DHHA1 domain; Region: DHHA1; pfam02272 347495011832 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 347495011833 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 347495011834 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 347495011835 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 347495011836 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 347495011837 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 347495011838 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 347495011839 Protein export membrane protein; Region: SecD_SecF; pfam02355 347495011840 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 347495011841 stage V sporulation protein B; Region: spore_V_B; TIGR02900 347495011842 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 347495011843 Predicted membrane protein [Function unknown]; Region: COG2323 347495011844 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 347495011845 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 347495011846 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 347495011847 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 347495011848 potential frameshift: common BLAST hit: gi|118479574|ref|YP_896725.1| S-adenosylmethionine--tRNA ribosyltransferase-isomerase 347495011849 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 347495011850 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 347495011851 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 347495011852 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 347495011853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495011854 Walker A motif; other site 347495011855 ATP binding site [chemical binding]; other site 347495011856 Walker B motif; other site 347495011857 arginine finger; other site 347495011858 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 347495011859 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 347495011860 RuvA N terminal domain; Region: RuvA_N; pfam01330 347495011861 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 347495011862 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495011863 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 347495011864 putative ligand binding residues [chemical binding]; other site 347495011865 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 347495011866 BofC C-terminal domain; Region: BofC_C; pfam08955 347495011867 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495011868 EamA-like transporter family; Region: EamA; pfam00892 347495011869 EamA-like transporter family; Region: EamA; pfam00892 347495011870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495011871 dimerization interface [polypeptide binding]; other site 347495011872 putative DNA binding site [nucleotide binding]; other site 347495011873 putative Zn2+ binding site [ion binding]; other site 347495011874 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 347495011875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495011876 quinolinate synthetase; Provisional; Region: PRK09375 347495011877 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 347495011878 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 347495011879 dimerization interface [polypeptide binding]; other site 347495011880 active site 347495011881 L-aspartate oxidase; Provisional; Region: PRK08071 347495011882 L-aspartate oxidase; Provisional; Region: PRK06175 347495011883 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 347495011884 cysteine desulfurase; Provisional; Region: PRK02948 347495011885 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 347495011886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495011887 catalytic residue [active] 347495011888 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 347495011889 HTH domain; Region: HTH_11; pfam08279 347495011890 3H domain; Region: 3H; pfam02829 347495011891 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 347495011892 MOSC domain; Region: MOSC; pfam03473 347495011893 3-alpha domain; Region: 3-alpha; pfam03475 347495011894 prephenate dehydratase; Provisional; Region: PRK11898 347495011895 Prephenate dehydratase; Region: PDT; pfam00800 347495011896 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 347495011897 putative L-Phe binding site [chemical binding]; other site 347495011898 FtsX-like permease family; Region: FtsX; pfam02687 347495011899 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495011900 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495011901 FtsX-like permease family; Region: FtsX; pfam02687 347495011902 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495011903 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495011904 Walker A/P-loop; other site 347495011905 ATP binding site [chemical binding]; other site 347495011906 Q-loop/lid; other site 347495011907 ABC transporter signature motif; other site 347495011908 Walker B; other site 347495011909 D-loop; other site 347495011910 H-loop/switch region; other site 347495011911 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495011912 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 347495011913 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495011914 ATP binding site [chemical binding]; other site 347495011915 Mg2+ binding site [ion binding]; other site 347495011916 G-X-G motif; other site 347495011917 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495011918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495011919 active site 347495011920 phosphorylation site [posttranslational modification] 347495011921 intermolecular recognition site; other site 347495011922 dimerization interface [polypeptide binding]; other site 347495011923 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495011924 DNA binding site [nucleotide binding] 347495011925 GTPase CgtA; Reviewed; Region: obgE; PRK12297 347495011926 GTP1/OBG; Region: GTP1_OBG; pfam01018 347495011927 Obg GTPase; Region: Obg; cd01898 347495011928 G1 box; other site 347495011929 GTP/Mg2+ binding site [chemical binding]; other site 347495011930 Switch I region; other site 347495011931 G2 box; other site 347495011932 G3 box; other site 347495011933 Switch II region; other site 347495011934 G4 box; other site 347495011935 G5 box; other site 347495011936 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 347495011937 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 347495011938 hypothetical protein; Provisional; Region: PRK14553 347495011939 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 347495011940 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 347495011941 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 347495011942 homodimer interface [polypeptide binding]; other site 347495011943 oligonucleotide binding site [chemical binding]; other site 347495011944 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 347495011945 Peptidase family M50; Region: Peptidase_M50; pfam02163 347495011946 active site 347495011947 putative substrate binding region [chemical binding]; other site 347495011948 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495011949 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495011950 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 347495011951 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 347495011952 Switch I; other site 347495011953 Switch II; other site 347495011954 septum formation inhibitor; Reviewed; Region: minC; PRK00513 347495011955 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 347495011956 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 347495011957 rod shape-determining protein MreC; Provisional; Region: PRK13922 347495011958 rod shape-determining protein MreC; Region: MreC; pfam04085 347495011959 rod shape-determining protein MreB; Provisional; Region: PRK13927 347495011960 MreB and similar proteins; Region: MreB_like; cd10225 347495011961 nucleotide binding site [chemical binding]; other site 347495011962 Mg binding site [ion binding]; other site 347495011963 putative protofilament interaction site [polypeptide binding]; other site 347495011964 RodZ interaction site [polypeptide binding]; other site 347495011965 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 347495011966 active site 347495011967 catalytic residues [active] 347495011968 DNA binding site [nucleotide binding] 347495011969 Int/Topo IB signature motif; other site 347495011970 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 347495011971 homotrimer interaction site [polypeptide binding]; other site 347495011972 putative active site [active] 347495011973 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 347495011974 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 347495011975 HlyD family secretion protein; Region: HlyD_3; pfam13437 347495011976 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 347495011977 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 347495011978 putative active site [active] 347495011979 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495011980 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495011981 Walker A/P-loop; other site 347495011982 ATP binding site [chemical binding]; other site 347495011983 Q-loop/lid; other site 347495011984 ABC transporter signature motif; other site 347495011985 Walker B; other site 347495011986 D-loop; other site 347495011987 H-loop/switch region; other site 347495011988 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495011989 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 347495011990 MPN+ (JAMM) motif; other site 347495011991 Zinc-binding site [ion binding]; other site 347495011992 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 347495011993 active site 347495011994 DNA binding site [nucleotide binding] 347495011995 Int/Topo IB signature motif; other site 347495011996 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 347495011997 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 347495011998 active site 347495011999 catalytic residues [active] 347495012000 DNA binding site [nucleotide binding] 347495012001 Int/Topo IB signature motif; other site 347495012002 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 347495012003 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 347495012004 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 347495012005 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 347495012006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495012007 ATP binding site [chemical binding]; other site 347495012008 putative Mg++ binding site [ion binding]; other site 347495012009 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 347495012010 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 347495012011 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 347495012012 HsdM N-terminal domain; Region: HsdM_N; pfam12161 347495012013 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 347495012014 Methyltransferase domain; Region: Methyltransf_26; pfam13659 347495012015 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 347495012016 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 347495012017 hypothetical protein; Reviewed; Region: PRK00024 347495012018 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 347495012019 Maf-like protein; Region: Maf; pfam02545 347495012020 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 347495012021 active site 347495012022 dimer interface [polypeptide binding]; other site 347495012023 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 347495012024 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 347495012025 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 347495012026 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 347495012027 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 347495012028 active site 347495012029 HIGH motif; other site 347495012030 nucleotide binding site [chemical binding]; other site 347495012031 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 347495012032 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 347495012033 active site 347495012034 KMSKS motif; other site 347495012035 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 347495012036 tRNA binding surface [nucleotide binding]; other site 347495012037 anticodon binding site; other site 347495012038 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 347495012039 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 347495012040 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 347495012041 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 347495012042 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 347495012043 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 347495012044 inhibitor-cofactor binding pocket; inhibition site 347495012045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495012046 catalytic residue [active] 347495012047 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 347495012048 dimer interface [polypeptide binding]; other site 347495012049 active site 347495012050 Schiff base residues; other site 347495012051 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 347495012052 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 347495012053 active site 347495012054 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 347495012055 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 347495012056 domain interfaces; other site 347495012057 active site 347495012058 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 347495012059 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 347495012060 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 347495012061 tRNA; other site 347495012062 putative tRNA binding site [nucleotide binding]; other site 347495012063 putative NADP binding site [chemical binding]; other site 347495012064 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 347495012065 Transcriptional regulators [Transcription]; Region: MarR; COG1846 347495012066 MarR family; Region: MarR; pfam01047 347495012067 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 347495012068 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 347495012069 G1 box; other site 347495012070 GTP/Mg2+ binding site [chemical binding]; other site 347495012071 Switch I region; other site 347495012072 G2 box; other site 347495012073 G3 box; other site 347495012074 Switch II region; other site 347495012075 G4 box; other site 347495012076 G5 box; other site 347495012077 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 347495012078 Found in ATP-dependent protease La (LON); Region: LON; smart00464 347495012079 Found in ATP-dependent protease La (LON); Region: LON; smart00464 347495012080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495012081 Walker A motif; other site 347495012082 ATP binding site [chemical binding]; other site 347495012083 Walker B motif; other site 347495012084 arginine finger; other site 347495012085 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 347495012086 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 347495012087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495012088 Walker A motif; other site 347495012089 ATP binding site [chemical binding]; other site 347495012090 Walker B motif; other site 347495012091 arginine finger; other site 347495012092 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 347495012093 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 347495012094 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 347495012095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495012096 Walker A motif; other site 347495012097 ATP binding site [chemical binding]; other site 347495012098 Walker B motif; other site 347495012099 arginine finger; other site 347495012100 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 347495012101 trigger factor; Provisional; Region: tig; PRK01490 347495012102 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 347495012103 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 347495012104 Protein of unknown function (DUF3257); Region: DUF3257; pfam11645 347495012105 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 347495012106 pentamer interface [polypeptide binding]; other site 347495012107 dodecaamer interface [polypeptide binding]; other site 347495012108 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 347495012109 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 347495012110 active site 347495012111 metal binding site [ion binding]; metal-binding site 347495012112 homotetramer interface [polypeptide binding]; other site 347495012113 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 347495012114 active site 347495012115 dimerization interface [polypeptide binding]; other site 347495012116 ribonuclease PH; Reviewed; Region: rph; PRK00173 347495012117 Ribonuclease PH; Region: RNase_PH_bact; cd11362 347495012118 hexamer interface [polypeptide binding]; other site 347495012119 active site 347495012120 Sporulation and spore germination; Region: Germane; pfam10646 347495012121 Spore germination protein [General function prediction only]; Region: COG5401 347495012122 Sporulation and spore germination; Region: Germane; pfam10646 347495012123 glutamate racemase; Provisional; Region: PRK00865 347495012124 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495012125 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 347495012126 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 347495012127 potential catalytic triad [active] 347495012128 conserved cys residue [active] 347495012129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495012130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495012131 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 347495012132 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 347495012133 potential catalytic triad [active] 347495012134 conserved cys residue [active] 347495012135 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 347495012136 active site 347495012137 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495012138 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495012139 DNA binding residues [nucleotide binding] 347495012140 dimerization interface [polypeptide binding]; other site 347495012141 putative uracil/xanthine transporter; Provisional; Region: PRK11412 347495012142 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495012143 EamA-like transporter family; Region: EamA; pfam00892 347495012144 EamA-like transporter family; Region: EamA; pfam00892 347495012145 putative deaminase; Validated; Region: PRK06846 347495012146 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 347495012147 active site 347495012148 putative deaminase; Validated; Region: PRK06846 347495012149 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 347495012150 active site 347495012151 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 347495012152 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 347495012153 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 347495012154 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 347495012155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495012156 dimer interface [polypeptide binding]; other site 347495012157 conserved gate region; other site 347495012158 ABC-ATPase subunit interface; other site 347495012159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 347495012160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495012161 dimer interface [polypeptide binding]; other site 347495012162 conserved gate region; other site 347495012163 putative PBP binding loops; other site 347495012164 ABC-ATPase subunit interface; other site 347495012165 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 347495012166 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495012167 Walker A/P-loop; other site 347495012168 ATP binding site [chemical binding]; other site 347495012169 Q-loop/lid; other site 347495012170 ABC transporter signature motif; other site 347495012171 Walker B; other site 347495012172 D-loop; other site 347495012173 H-loop/switch region; other site 347495012174 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 347495012175 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 347495012176 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 347495012177 Walker A/P-loop; other site 347495012178 ATP binding site [chemical binding]; other site 347495012179 Q-loop/lid; other site 347495012180 ABC transporter signature motif; other site 347495012181 Walker B; other site 347495012182 D-loop; other site 347495012183 H-loop/switch region; other site 347495012184 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 347495012185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 347495012186 Histidine kinase; Region: His_kinase; pfam06580 347495012187 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 347495012188 ATP binding site [chemical binding]; other site 347495012189 Mg2+ binding site [ion binding]; other site 347495012190 G-X-G motif; other site 347495012191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495012192 Response regulator receiver domain; Region: Response_reg; pfam00072 347495012193 active site 347495012194 phosphorylation site [posttranslational modification] 347495012195 intermolecular recognition site; other site 347495012196 dimerization interface [polypeptide binding]; other site 347495012197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495012198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 347495012199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495012200 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 347495012201 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 347495012202 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 347495012203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495012204 non-specific DNA binding site [nucleotide binding]; other site 347495012205 salt bridge; other site 347495012206 sequence-specific DNA binding site [nucleotide binding]; other site 347495012207 Cupin domain; Region: Cupin_2; pfam07883 347495012208 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 347495012209 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 347495012210 amphipathic channel; other site 347495012211 Asn-Pro-Ala signature motifs; other site 347495012212 Probable transposase; Region: OrfB_IS605; pfam01385 347495012213 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 347495012214 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 347495012215 Predicted transcriptional regulator [Transcription]; Region: COG1959 347495012216 Transcriptional regulator; Region: Rrf2; pfam02082 347495012217 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 347495012218 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 347495012219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495012220 Walker A/P-loop; other site 347495012221 ATP binding site [chemical binding]; other site 347495012222 Q-loop/lid; other site 347495012223 ABC transporter signature motif; other site 347495012224 Walker B; other site 347495012225 D-loop; other site 347495012226 H-loop/switch region; other site 347495012227 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 347495012228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495012229 active site 347495012230 motif I; other site 347495012231 motif II; other site 347495012232 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 347495012233 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 347495012234 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 347495012235 ligand binding site [chemical binding]; other site 347495012236 flagellar motor protein MotA; Validated; Region: PRK08124 347495012237 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 347495012238 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 347495012239 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 347495012240 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 347495012241 active site 347495012242 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 347495012243 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 347495012244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 347495012245 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 347495012246 L-aspartate oxidase; Provisional; Region: PRK06175 347495012247 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 347495012248 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 347495012249 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 347495012250 putative Iron-sulfur protein interface [polypeptide binding]; other site 347495012251 proximal heme binding site [chemical binding]; other site 347495012252 distal heme binding site [chemical binding]; other site 347495012253 putative dimer interface [polypeptide binding]; other site 347495012254 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 347495012255 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 347495012256 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 347495012257 GIY-YIG motif/motif A; other site 347495012258 active site 347495012259 catalytic site [active] 347495012260 putative DNA binding site [nucleotide binding]; other site 347495012261 metal binding site [ion binding]; metal-binding site 347495012262 UvrB/uvrC motif; Region: UVR; pfam02151 347495012263 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 347495012264 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 347495012265 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 347495012266 catalytic residues [active] 347495012267 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 347495012268 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 347495012269 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 347495012270 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 347495012271 Ligand binding site [chemical binding]; other site 347495012272 Electron transfer flavoprotein domain; Region: ETF; pfam01012 347495012273 enoyl-CoA hydratase; Provisional; Region: PRK07658 347495012274 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495012275 substrate binding site [chemical binding]; other site 347495012276 oxyanion hole (OAH) forming residues; other site 347495012277 trimer interface [polypeptide binding]; other site 347495012278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 347495012279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495012280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495012281 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 347495012282 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 347495012283 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 347495012284 acyl-activating enzyme (AAE) consensus motif; other site 347495012285 putative AMP binding site [chemical binding]; other site 347495012286 putative active site [active] 347495012287 putative CoA binding site [chemical binding]; other site 347495012288 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 347495012289 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 347495012290 siderophore binding site; other site 347495012291 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495012292 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495012293 ABC-ATPase subunit interface; other site 347495012294 dimer interface [polypeptide binding]; other site 347495012295 putative PBP binding regions; other site 347495012296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495012297 ABC-ATPase subunit interface; other site 347495012298 dimer interface [polypeptide binding]; other site 347495012299 putative PBP binding regions; other site 347495012300 DinB family; Region: DinB; pfam05163 347495012301 DinB superfamily; Region: DinB_2; pfam12867 347495012302 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 347495012303 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 347495012304 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 347495012305 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495012306 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 347495012307 Walker A/P-loop; other site 347495012308 ATP binding site [chemical binding]; other site 347495012309 Q-loop/lid; other site 347495012310 ABC transporter signature motif; other site 347495012311 Walker B; other site 347495012312 D-loop; other site 347495012313 H-loop/switch region; other site 347495012314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495012315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495012316 dimer interface [polypeptide binding]; other site 347495012317 phosphorylation site [posttranslational modification] 347495012318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495012319 ATP binding site [chemical binding]; other site 347495012320 Mg2+ binding site [ion binding]; other site 347495012321 G-X-G motif; other site 347495012322 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495012323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495012324 active site 347495012325 phosphorylation site [posttranslational modification] 347495012326 intermolecular recognition site; other site 347495012327 dimerization interface [polypeptide binding]; other site 347495012328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495012329 DNA binding site [nucleotide binding] 347495012330 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 347495012331 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 347495012332 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 347495012333 putative RNA binding site [nucleotide binding]; other site 347495012334 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 347495012335 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 347495012336 Neurotransmitter-gated ion-channel transmembrane region; Region: Neur_chan_memb; pfam02932 347495012337 TrkA-N domain; Region: TrkA_N; pfam02254 347495012338 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 347495012339 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 347495012340 active site 347495012341 catalytic site [active] 347495012342 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 347495012343 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 347495012344 Walker A/P-loop; other site 347495012345 ATP binding site [chemical binding]; other site 347495012346 Q-loop/lid; other site 347495012347 ABC transporter signature motif; other site 347495012348 Walker B; other site 347495012349 D-loop; other site 347495012350 H-loop/switch region; other site 347495012351 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 347495012352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495012353 ABC-ATPase subunit interface; other site 347495012354 dimer interface [polypeptide binding]; other site 347495012355 putative PBP binding regions; other site 347495012356 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 347495012357 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 347495012358 intersubunit interface [polypeptide binding]; other site 347495012359 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495012360 heme-binding site [chemical binding]; other site 347495012361 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495012362 heme-binding site [chemical binding]; other site 347495012363 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 347495012364 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 347495012365 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 347495012366 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 347495012367 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 347495012368 Repeat of unknown function (DUF1388); Region: DUF1388; pfam07142 347495012369 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495012370 heme-binding site [chemical binding]; other site 347495012371 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495012372 heme-binding site [chemical binding]; other site 347495012373 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495012374 heme-binding site [chemical binding]; other site 347495012375 heme uptake protein IsdC; Region: IsdC; TIGR03656 347495012376 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 347495012377 heme-binding site [chemical binding]; other site 347495012378 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 347495012379 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 347495012380 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 347495012381 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495012382 RNA binding surface [nucleotide binding]; other site 347495012383 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 347495012384 probable active site [active] 347495012385 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 347495012386 MutS domain III; Region: MutS_III; pfam05192 347495012387 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 347495012388 Walker A/P-loop; other site 347495012389 ATP binding site [chemical binding]; other site 347495012390 Q-loop/lid; other site 347495012391 ABC transporter signature motif; other site 347495012392 Walker B; other site 347495012393 D-loop; other site 347495012394 H-loop/switch region; other site 347495012395 Smr domain; Region: Smr; pfam01713 347495012396 hypothetical protein; Provisional; Region: PRK08609 347495012397 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 347495012398 active site 347495012399 primer binding site [nucleotide binding]; other site 347495012400 NTP binding site [chemical binding]; other site 347495012401 metal binding triad [ion binding]; metal-binding site 347495012402 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 347495012403 active site 347495012404 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 347495012405 Colicin V production protein; Region: Colicin_V; pfam02674 347495012406 cell division protein ZapA; Provisional; Region: PRK14126 347495012407 ribonuclease HIII; Provisional; Region: PRK00996 347495012408 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 347495012409 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 347495012410 RNA/DNA hybrid binding site [nucleotide binding]; other site 347495012411 active site 347495012412 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 347495012413 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 347495012414 putative dimer interface [polypeptide binding]; other site 347495012415 putative anticodon binding site; other site 347495012416 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 347495012417 homodimer interface [polypeptide binding]; other site 347495012418 motif 1; other site 347495012419 motif 2; other site 347495012420 active site 347495012421 motif 3; other site 347495012422 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 347495012423 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 347495012424 putative tRNA-binding site [nucleotide binding]; other site 347495012425 B3/4 domain; Region: B3_4; pfam03483 347495012426 tRNA synthetase B5 domain; Region: B5; smart00874 347495012427 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 347495012428 dimer interface [polypeptide binding]; other site 347495012429 motif 1; other site 347495012430 motif 3; other site 347495012431 motif 2; other site 347495012432 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 347495012433 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 347495012434 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 347495012435 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 347495012436 dimer interface [polypeptide binding]; other site 347495012437 motif 1; other site 347495012438 active site 347495012439 motif 2; other site 347495012440 motif 3; other site 347495012441 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 347495012442 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 347495012443 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 347495012444 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 347495012445 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495012446 Zn2+ binding site [ion binding]; other site 347495012447 Mg2+ binding site [ion binding]; other site 347495012448 CAAX protease self-immunity; Region: Abi; pfam02517 347495012449 CAAX protease self-immunity; Region: Abi; pfam02517 347495012450 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495012451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495012452 putative substrate translocation pore; other site 347495012453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495012454 HlyD family secretion protein; Region: HlyD_3; pfam13437 347495012455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495012456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495012457 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 347495012458 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 347495012459 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 347495012460 oligomer interface [polypeptide binding]; other site 347495012461 active site 347495012462 metal binding site [ion binding]; metal-binding site 347495012463 dUTPase; Region: dUTPase_2; pfam08761 347495012464 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 347495012465 active site 347495012466 homodimer interface [polypeptide binding]; other site 347495012467 metal binding site [ion binding]; metal-binding site 347495012468 potential frameshift: common BLAST hit: gi|301056079|ref|YP_003794290.1| 50S ribosomal protein L20 347495012469 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 347495012470 L21 binding site [polypeptide binding]; other site 347495012471 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 347495012472 23S rRNA binding site [nucleotide binding]; other site 347495012473 L13 binding site [polypeptide binding]; other site 347495012474 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 347495012475 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 347495012476 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 347495012477 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 347495012478 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 347495012479 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 347495012480 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 347495012481 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 347495012482 active site 347495012483 dimer interface [polypeptide binding]; other site 347495012484 motif 1; other site 347495012485 motif 2; other site 347495012486 motif 3; other site 347495012487 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 347495012488 anticodon binding site; other site 347495012489 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 347495012490 primosomal protein DnaI; Reviewed; Region: PRK08939 347495012491 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 347495012492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495012493 Walker A motif; other site 347495012494 ATP binding site [chemical binding]; other site 347495012495 Walker B motif; other site 347495012496 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 347495012497 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 347495012498 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 347495012499 ATP cone domain; Region: ATP-cone; pfam03477 347495012500 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 347495012501 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 347495012502 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 347495012503 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 347495012504 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 347495012505 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 347495012506 CoA-binding site [chemical binding]; other site 347495012507 ATP-binding [chemical binding]; other site 347495012508 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 347495012509 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 347495012510 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 347495012511 DNA binding site [nucleotide binding] 347495012512 catalytic residue [active] 347495012513 H2TH interface [polypeptide binding]; other site 347495012514 putative catalytic residues [active] 347495012515 turnover-facilitating residue; other site 347495012516 intercalation triad [nucleotide binding]; other site 347495012517 8OG recognition residue [nucleotide binding]; other site 347495012518 putative reading head residues; other site 347495012519 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 347495012520 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 347495012521 DNA polymerase I; Provisional; Region: PRK05755 347495012522 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 347495012523 active site 347495012524 metal binding site 1 [ion binding]; metal-binding site 347495012525 putative 5' ssDNA interaction site; other site 347495012526 metal binding site 3; metal-binding site 347495012527 metal binding site 2 [ion binding]; metal-binding site 347495012528 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 347495012529 putative DNA binding site [nucleotide binding]; other site 347495012530 putative metal binding site [ion binding]; other site 347495012531 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 347495012532 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 347495012533 active site 347495012534 DNA binding site [nucleotide binding] 347495012535 catalytic site [active] 347495012536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495012537 dimerization interface [polypeptide binding]; other site 347495012538 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 347495012539 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495012540 putative active site [active] 347495012541 heme pocket [chemical binding]; other site 347495012542 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495012543 dimer interface [polypeptide binding]; other site 347495012544 phosphorylation site [posttranslational modification] 347495012545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495012546 ATP binding site [chemical binding]; other site 347495012547 Mg2+ binding site [ion binding]; other site 347495012548 G-X-G motif; other site 347495012549 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495012550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495012551 active site 347495012552 phosphorylation site [posttranslational modification] 347495012553 intermolecular recognition site; other site 347495012554 dimerization interface [polypeptide binding]; other site 347495012555 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495012556 DNA binding site [nucleotide binding] 347495012557 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 347495012558 active site 2 [active] 347495012559 active site 1 [active] 347495012560 malate dehydrogenase; Reviewed; Region: PRK06223 347495012561 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 347495012562 NAD(P) binding site [chemical binding]; other site 347495012563 dimer interface [polypeptide binding]; other site 347495012564 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495012565 substrate binding site [chemical binding]; other site 347495012566 isocitrate dehydrogenase; Reviewed; Region: PRK07006 347495012567 isocitrate dehydrogenase; Validated; Region: PRK07362 347495012568 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 347495012569 dimer interface [polypeptide binding]; other site 347495012570 Citrate synthase; Region: Citrate_synt; pfam00285 347495012571 active site 347495012572 citrylCoA binding site [chemical binding]; other site 347495012573 oxalacetate/citrate binding site [chemical binding]; other site 347495012574 coenzyme A binding site [chemical binding]; other site 347495012575 catalytic triad [active] 347495012576 Protein of unknown function (DUF441); Region: DUF441; pfam04284 347495012577 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 347495012578 Domain of unknown function DUF20; Region: UPF0118; pfam01594 347495012579 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 347495012580 pyruvate kinase; Provisional; Region: PRK06354 347495012581 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 347495012582 domain interfaces; other site 347495012583 active site 347495012584 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 347495012585 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 347495012586 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 347495012587 active site 347495012588 ADP/pyrophosphate binding site [chemical binding]; other site 347495012589 dimerization interface [polypeptide binding]; other site 347495012590 allosteric effector site; other site 347495012591 fructose-1,6-bisphosphate binding site; other site 347495012592 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 347495012593 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 347495012594 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 347495012595 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 347495012596 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 347495012597 Transcriptional regulators [Transcription]; Region: FadR; COG2186 347495012598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495012599 DNA-binding site [nucleotide binding]; DNA binding site 347495012600 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 347495012601 Malic enzyme, N-terminal domain; Region: malic; pfam00390 347495012602 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 347495012603 putative NAD(P) binding site [chemical binding]; other site 347495012604 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 347495012605 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 347495012606 active site 347495012607 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 347495012608 generic binding surface II; other site 347495012609 generic binding surface I; other site 347495012610 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 347495012611 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 347495012612 DHH family; Region: DHH; pfam01368 347495012613 DHHA1 domain; Region: DHHA1; pfam02272 347495012614 YtpI-like protein; Region: YtpI; pfam14007 347495012615 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 347495012616 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 347495012617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495012618 DNA-binding site [nucleotide binding]; DNA binding site 347495012619 DRTGG domain; Region: DRTGG; pfam07085 347495012620 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 347495012621 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 347495012622 active site 2 [active] 347495012623 active site 1 [active] 347495012624 metal-dependent hydrolase; Provisional; Region: PRK00685 347495012625 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 347495012626 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 347495012627 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 347495012628 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 347495012629 active site 347495012630 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 347495012631 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 347495012632 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 347495012633 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 347495012634 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 347495012635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495012636 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 347495012637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 347495012638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495012639 Coenzyme A binding pocket [chemical binding]; other site 347495012640 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495012641 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495012642 non-specific DNA binding site [nucleotide binding]; other site 347495012643 salt bridge; other site 347495012644 sequence-specific DNA binding site [nucleotide binding]; other site 347495012645 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 347495012646 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 347495012647 hexamer interface [polypeptide binding]; other site 347495012648 ligand binding site [chemical binding]; other site 347495012649 putative active site [active] 347495012650 NAD(P) binding site [chemical binding]; other site 347495012651 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 347495012652 classical (c) SDRs; Region: SDR_c; cd05233 347495012653 NAD(P) binding site [chemical binding]; other site 347495012654 active site 347495012655 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 347495012656 Ligand Binding Site [chemical binding]; other site 347495012657 argininosuccinate lyase; Provisional; Region: PRK00855 347495012658 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 347495012659 active sites [active] 347495012660 tetramer interface [polypeptide binding]; other site 347495012661 argininosuccinate synthase; Provisional; Region: PRK13820 347495012662 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 347495012663 ANP binding site [chemical binding]; other site 347495012664 Substrate Binding Site II [chemical binding]; other site 347495012665 Substrate Binding Site I [chemical binding]; other site 347495012666 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495012667 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495012668 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495012669 EcsC protein family; Region: EcsC; pfam12787 347495012670 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 347495012671 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 347495012672 nudix motif; other site 347495012673 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 347495012674 propionate/acetate kinase; Provisional; Region: PRK12379 347495012675 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 347495012676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495012677 S-adenosylmethionine binding site [chemical binding]; other site 347495012678 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 347495012679 dimer interface [polypeptide binding]; other site 347495012680 catalytic triad [active] 347495012681 peroxidatic and resolving cysteines [active] 347495012682 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 347495012683 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 347495012684 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 347495012685 ATP-NAD kinase; Region: NAD_kinase; pfam01513 347495012686 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 347495012687 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 347495012688 active site 347495012689 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495012690 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 347495012691 dimer interface [polypeptide binding]; other site 347495012692 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 347495012693 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 347495012694 active site 347495012695 acyl-activating enzyme (AAE) consensus motif; other site 347495012696 putative CoA binding site [chemical binding]; other site 347495012697 AMP binding site [chemical binding]; other site 347495012698 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 347495012699 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 347495012700 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 347495012701 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 347495012702 Ligand Binding Site [chemical binding]; other site 347495012703 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 347495012704 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 347495012705 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495012706 catalytic residue [active] 347495012707 septation ring formation regulator EzrA; Provisional; Region: PRK04778 347495012708 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495012709 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495012710 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 347495012711 dimerization interface [polypeptide binding]; other site 347495012712 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495012713 EamA-like transporter family; Region: EamA; pfam00892 347495012714 EamA-like transporter family; Region: EamA; pfam00892 347495012715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495012716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495012717 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 347495012718 GAF domain; Region: GAF_2; pfam13185 347495012719 methionine gamma-lyase; Provisional; Region: PRK06767 347495012720 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 347495012721 homodimer interface [polypeptide binding]; other site 347495012722 substrate-cofactor binding pocket; other site 347495012723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495012724 catalytic residue [active] 347495012725 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 347495012726 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 347495012727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495012728 RNA binding surface [nucleotide binding]; other site 347495012729 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 347495012730 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 347495012731 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 347495012732 active site 347495012733 HIGH motif; other site 347495012734 dimer interface [polypeptide binding]; other site 347495012735 KMSKS motif; other site 347495012736 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495012737 RNA binding surface [nucleotide binding]; other site 347495012738 acetyl-CoA synthetase; Provisional; Region: PRK04319 347495012739 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 347495012740 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 347495012741 active site 347495012742 acyl-activating enzyme (AAE) consensus motif; other site 347495012743 putative CoA binding site [chemical binding]; other site 347495012744 AMP binding site [chemical binding]; other site 347495012745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495012746 Coenzyme A binding pocket [chemical binding]; other site 347495012747 FOG: CBS domain [General function prediction only]; Region: COG0517 347495012748 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 347495012749 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 347495012750 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 347495012751 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 347495012752 active site 347495012753 Zn binding site [ion binding]; other site 347495012754 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 347495012755 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495012756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495012757 active site 347495012758 phosphorylation site [posttranslational modification] 347495012759 intermolecular recognition site; other site 347495012760 dimerization interface [polypeptide binding]; other site 347495012761 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495012762 DNA binding site [nucleotide binding] 347495012763 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495012764 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495012765 dimerization interface [polypeptide binding]; other site 347495012766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495012767 dimer interface [polypeptide binding]; other site 347495012768 phosphorylation site [posttranslational modification] 347495012769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495012770 ATP binding site [chemical binding]; other site 347495012771 Mg2+ binding site [ion binding]; other site 347495012772 G-X-G motif; other site 347495012773 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 347495012774 Ankyrin repeat; Region: Ank; pfam00023 347495012775 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 347495012776 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 347495012777 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 347495012778 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 347495012779 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 347495012780 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 347495012781 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 347495012782 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 347495012783 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 347495012784 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 347495012785 catabolite control protein A; Region: ccpA; TIGR01481 347495012786 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495012787 DNA binding site [nucleotide binding] 347495012788 domain linker motif; other site 347495012789 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 347495012790 dimerization interface [polypeptide binding]; other site 347495012791 effector binding site; other site 347495012792 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 347495012793 putative dimer interface [polypeptide binding]; other site 347495012794 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 347495012795 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 347495012796 putative dimer interface [polypeptide binding]; other site 347495012797 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 347495012798 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 347495012799 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 347495012800 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 347495012801 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 347495012802 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495012803 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495012804 Coenzyme A binding pocket [chemical binding]; other site 347495012805 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 347495012806 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 347495012807 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 347495012808 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 347495012809 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 347495012810 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 347495012811 active site 347495012812 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 347495012813 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 347495012814 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 347495012815 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 347495012816 putative tRNA-binding site [nucleotide binding]; other site 347495012817 hypothetical protein; Provisional; Region: PRK13668 347495012818 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 347495012819 catalytic residues [active] 347495012820 NTPase; Reviewed; Region: PRK03114 347495012821 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 347495012822 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 347495012823 oligomer interface [polypeptide binding]; other site 347495012824 active site 347495012825 metal binding site [ion binding]; metal-binding site 347495012826 Predicted small secreted protein [Function unknown]; Region: COG5584 347495012827 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495012828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495012829 S-adenosylmethionine binding site [chemical binding]; other site 347495012830 YtzH-like protein; Region: YtzH; pfam14165 347495012831 Phosphotransferase enzyme family; Region: APH; pfam01636 347495012832 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 347495012833 active site 347495012834 substrate binding site [chemical binding]; other site 347495012835 ATP binding site [chemical binding]; other site 347495012836 pullulanase, type I; Region: pulA_typeI; TIGR02104 347495012837 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 347495012838 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 347495012839 Ca binding site [ion binding]; other site 347495012840 active site 347495012841 catalytic site [active] 347495012842 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 347495012843 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 347495012844 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 347495012845 dipeptidase PepV; Reviewed; Region: PRK07318 347495012846 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 347495012847 active site 347495012848 metal binding site [ion binding]; metal-binding site 347495012849 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 347495012850 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 347495012851 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495012852 RNA binding surface [nucleotide binding]; other site 347495012853 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 347495012854 active site 347495012855 uracil binding [chemical binding]; other site 347495012856 stage V sporulation protein B; Region: spore_V_B; TIGR02900 347495012857 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 347495012858 HI0933-like protein; Region: HI0933_like; pfam03486 347495012859 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495012860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495012861 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 347495012862 putative substrate translocation pore; other site 347495012863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495012864 dimerization interface [polypeptide binding]; other site 347495012865 putative DNA binding site [nucleotide binding]; other site 347495012866 putative Zn2+ binding site [ion binding]; other site 347495012867 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 347495012868 putative hydrophobic ligand binding site [chemical binding]; other site 347495012869 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 347495012870 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 347495012871 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 347495012872 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 347495012873 glucose-1-dehydrogenase; Provisional; Region: PRK08936 347495012874 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 347495012875 NAD binding site [chemical binding]; other site 347495012876 homodimer interface [polypeptide binding]; other site 347495012877 active site 347495012878 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 347495012879 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 347495012880 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 347495012881 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 347495012882 MoaE interaction surface [polypeptide binding]; other site 347495012883 MoeB interaction surface [polypeptide binding]; other site 347495012884 thiocarboxylated glycine; other site 347495012885 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 347495012886 MoaE homodimer interface [polypeptide binding]; other site 347495012887 MoaD interaction [polypeptide binding]; other site 347495012888 active site residues [active] 347495012889 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 347495012890 Walker A motif; other site 347495012891 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 347495012892 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 347495012893 dimer interface [polypeptide binding]; other site 347495012894 putative functional site; other site 347495012895 putative MPT binding site; other site 347495012896 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 347495012897 trimer interface [polypeptide binding]; other site 347495012898 dimer interface [polypeptide binding]; other site 347495012899 putative active site [active] 347495012900 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 347495012901 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 347495012902 ATP binding site [chemical binding]; other site 347495012903 substrate interface [chemical binding]; other site 347495012904 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 347495012905 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495012906 FeS/SAM binding site; other site 347495012907 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 347495012908 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 347495012909 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 347495012910 active site residue [active] 347495012911 homoserine O-acetyltransferase; Provisional; Region: PRK06765 347495012912 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 347495012913 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 347495012914 Spore germination protein; Region: Spore_permease; pfam03845 347495012915 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495012916 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495012917 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 347495012918 putative nucleotide binding site [chemical binding]; other site 347495012919 putative metal binding site [ion binding]; other site 347495012920 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 347495012921 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 347495012922 HIGH motif; other site 347495012923 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 347495012924 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 347495012925 active site 347495012926 KMSKS motif; other site 347495012927 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 347495012928 tRNA binding surface [nucleotide binding]; other site 347495012929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495012930 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495012931 putative substrate translocation pore; other site 347495012932 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 347495012933 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 347495012934 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 347495012935 TrkA-C domain; Region: TrkA_C; pfam02080 347495012936 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 347495012937 Int/Topo IB signature motif; other site 347495012938 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495012939 FtsX-like permease family; Region: FtsX; pfam02687 347495012940 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495012941 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495012942 Walker A/P-loop; other site 347495012943 ATP binding site [chemical binding]; other site 347495012944 Q-loop/lid; other site 347495012945 ABC transporter signature motif; other site 347495012946 Walker B; other site 347495012947 D-loop; other site 347495012948 H-loop/switch region; other site 347495012949 Protein of unknown function (DUF418); Region: DUF418; cl12135 347495012950 Protein of unknown function (DUF418); Region: DUF418; pfam04235 347495012951 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 347495012952 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 347495012953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495012954 FeS/SAM binding site; other site 347495012955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495012956 S-adenosylmethionine binding site [chemical binding]; other site 347495012957 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495012958 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495012959 Walker A/P-loop; other site 347495012960 ATP binding site [chemical binding]; other site 347495012961 Q-loop/lid; other site 347495012962 ABC transporter signature motif; other site 347495012963 Walker B; other site 347495012964 D-loop; other site 347495012965 H-loop/switch region; other site 347495012966 aspartate racemase; Region: asp_race; TIGR00035 347495012967 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 347495012968 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 347495012969 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 347495012970 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 347495012971 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 347495012972 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 347495012973 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495012974 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495012975 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 347495012976 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 347495012977 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 347495012978 trimer interface [polypeptide binding]; other site 347495012979 putative metal binding site [ion binding]; other site 347495012980 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 347495012981 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 347495012982 active site 347495012983 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 347495012984 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 347495012985 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 347495012986 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 347495012987 GTP binding site; other site 347495012988 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 347495012989 MPT binding site; other site 347495012990 trimer interface [polypeptide binding]; other site 347495012991 S-adenosylmethionine synthetase; Validated; Region: PRK05250 347495012992 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 347495012993 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 347495012994 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 347495012995 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 347495012996 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 347495012997 active site 347495012998 substrate-binding site [chemical binding]; other site 347495012999 metal-binding site [ion binding] 347495013000 ATP binding site [chemical binding]; other site 347495013001 ATP synthase I chain; Region: ATP_synt_I; pfam03899 347495013002 EamA-like transporter family; Region: EamA; pfam00892 347495013003 EamA-like transporter family; Region: EamA; pfam00892 347495013004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 347495013005 Uncharacterized conserved protein [Function unknown]; Region: COG0327 347495013006 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 347495013007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495013008 ATP binding site [chemical binding]; other site 347495013009 Mg2+ binding site [ion binding]; other site 347495013010 G-X-G motif; other site 347495013011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495013012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495013013 dimer interface [polypeptide binding]; other site 347495013014 phosphorylation site [posttranslational modification] 347495013015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495013016 ATP binding site [chemical binding]; other site 347495013017 Mg2+ binding site [ion binding]; other site 347495013018 G-X-G motif; other site 347495013019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 347495013020 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 347495013021 Secretory lipase; Region: LIP; pfam03583 347495013022 Sulfatase; Region: Sulfatase; pfam00884 347495013023 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 347495013024 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 347495013025 NMT1-like family; Region: NMT1_2; pfam13379 347495013026 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 347495013027 Walker A/P-loop; other site 347495013028 ATP binding site [chemical binding]; other site 347495013029 ABC transporter; Region: ABC_tran; pfam00005 347495013030 Q-loop/lid; other site 347495013031 ABC transporter signature motif; other site 347495013032 Walker B; other site 347495013033 D-loop; other site 347495013034 H-loop/switch region; other site 347495013035 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 347495013036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495013037 dimer interface [polypeptide binding]; other site 347495013038 conserved gate region; other site 347495013039 putative PBP binding loops; other site 347495013040 ABC-ATPase subunit interface; other site 347495013041 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 347495013042 active site 347495013043 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 347495013044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495013045 motif II; other site 347495013046 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 347495013047 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 347495013048 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 347495013049 nudix motif; other site 347495013050 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 347495013051 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 347495013052 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 347495013053 S-ribosylhomocysteinase; Provisional; Region: PRK02260 347495013054 Haemolytic domain; Region: Haemolytic; pfam01809 347495013055 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 347495013056 active site clefts [active] 347495013057 zinc binding site [ion binding]; other site 347495013058 dimer interface [polypeptide binding]; other site 347495013059 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 347495013060 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 347495013061 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 347495013062 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 347495013063 S-layer homology domain; Region: SLH; pfam00395 347495013064 S-layer homology domain; Region: SLH; pfam00395 347495013065 S-layer homology domain; Region: SLH; pfam00395 347495013066 Excalibur calcium-binding domain; Region: Excalibur; smart00894 347495013067 Uncharacterized conserved protein [Function unknown]; Region: COG1434 347495013068 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 347495013069 putative active site [active] 347495013070 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495013071 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495013072 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495013073 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495013074 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 347495013075 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 347495013076 Predicted membrane protein [Function unknown]; Region: COG3766 347495013077 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 347495013078 hypothetical protein; Provisional; Region: PRK12473 347495013079 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 347495013080 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 347495013081 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 347495013082 G1 box; other site 347495013083 GTP/Mg2+ binding site [chemical binding]; other site 347495013084 Switch I region; other site 347495013085 G2 box; other site 347495013086 G3 box; other site 347495013087 Switch II region; other site 347495013088 G4 box; other site 347495013089 G5 box; other site 347495013090 Nucleoside recognition; Region: Gate; pfam07670 347495013091 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 347495013092 Nucleoside recognition; Region: Gate; pfam07670 347495013093 FeoA domain; Region: FeoA; pfam04023 347495013094 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 347495013095 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 347495013096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495013097 dimerization interface [polypeptide binding]; other site 347495013098 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495013099 dimer interface [polypeptide binding]; other site 347495013100 phosphorylation site [posttranslational modification] 347495013101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495013102 ATP binding site [chemical binding]; other site 347495013103 Mg2+ binding site [ion binding]; other site 347495013104 G-X-G motif; other site 347495013105 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495013106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495013107 active site 347495013108 phosphorylation site [posttranslational modification] 347495013109 intermolecular recognition site; other site 347495013110 dimerization interface [polypeptide binding]; other site 347495013111 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495013112 DNA binding site [nucleotide binding] 347495013113 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 347495013114 active site 347495013115 catalytic site [active] 347495013116 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495013117 active site 347495013118 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 347495013119 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 347495013120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 347495013121 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 347495013122 Probable transposase; Region: OrfB_IS605; pfam01385 347495013123 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 347495013124 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 347495013125 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 347495013126 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 347495013127 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 347495013128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495013129 S-adenosylmethionine binding site [chemical binding]; other site 347495013130 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495013131 FtsX-like permease family; Region: FtsX; pfam02687 347495013132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495013133 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495013134 Walker A/P-loop; other site 347495013135 ATP binding site [chemical binding]; other site 347495013136 Q-loop/lid; other site 347495013137 ABC transporter signature motif; other site 347495013138 Walker B; other site 347495013139 D-loop; other site 347495013140 H-loop/switch region; other site 347495013141 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 347495013142 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 347495013143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 347495013144 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495013145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495013146 active site 347495013147 phosphorylation site [posttranslational modification] 347495013148 intermolecular recognition site; other site 347495013149 dimerization interface [polypeptide binding]; other site 347495013150 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495013151 DNA binding site [nucleotide binding] 347495013152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495013153 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 347495013154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495013155 ATP binding site [chemical binding]; other site 347495013156 Mg2+ binding site [ion binding]; other site 347495013157 G-X-G motif; other site 347495013158 FtsX-like permease family; Region: FtsX; pfam02687 347495013159 FtsX-like permease family; Region: FtsX; pfam02687 347495013160 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495013161 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495013162 Walker A/P-loop; other site 347495013163 ATP binding site [chemical binding]; other site 347495013164 Q-loop/lid; other site 347495013165 ABC transporter signature motif; other site 347495013166 Walker B; other site 347495013167 D-loop; other site 347495013168 H-loop/switch region; other site 347495013169 FtsX-like permease family; Region: FtsX; pfam02687 347495013170 GntP family permease; Region: GntP_permease; pfam02447 347495013171 fructuronate transporter; Provisional; Region: PRK10034; cl15264 347495013172 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 347495013173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 347495013174 DNA-binding site [nucleotide binding]; DNA binding site 347495013175 UTRA domain; Region: UTRA; pfam07702 347495013176 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 347495013177 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 347495013178 substrate binding site [chemical binding]; other site 347495013179 ATP binding site [chemical binding]; other site 347495013180 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 347495013181 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 347495013182 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495013183 catalytic residue [active] 347495013184 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 347495013185 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 347495013186 active site 347495013187 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 347495013188 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495013189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495013190 dimerization interface [polypeptide binding]; other site 347495013191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495013192 dimer interface [polypeptide binding]; other site 347495013193 phosphorylation site [posttranslational modification] 347495013194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495013195 ATP binding site [chemical binding]; other site 347495013196 Mg2+ binding site [ion binding]; other site 347495013197 G-X-G motif; other site 347495013198 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495013199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495013200 active site 347495013201 phosphorylation site [posttranslational modification] 347495013202 intermolecular recognition site; other site 347495013203 dimerization interface [polypeptide binding]; other site 347495013204 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495013205 DNA binding site [nucleotide binding] 347495013206 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 347495013207 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 347495013208 active site 347495013209 octamer interface [polypeptide binding]; other site 347495013210 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 347495013211 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 347495013212 acyl-activating enzyme (AAE) consensus motif; other site 347495013213 putative AMP binding site [chemical binding]; other site 347495013214 putative active site [active] 347495013215 putative CoA binding site [chemical binding]; other site 347495013216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495013217 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 347495013218 substrate binding site [chemical binding]; other site 347495013219 oxyanion hole (OAH) forming residues; other site 347495013220 trimer interface [polypeptide binding]; other site 347495013221 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 347495013222 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 347495013223 nucleophilic elbow; other site 347495013224 catalytic triad; other site 347495013225 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 347495013226 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 347495013227 dimer interface [polypeptide binding]; other site 347495013228 tetramer interface [polypeptide binding]; other site 347495013229 PYR/PP interface [polypeptide binding]; other site 347495013230 TPP binding site [chemical binding]; other site 347495013231 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 347495013232 TPP-binding site; other site 347495013233 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 347495013234 chorismate binding enzyme; Region: Chorismate_bind; cl10555 347495013235 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 347495013236 UbiA prenyltransferase family; Region: UbiA; pfam01040 347495013237 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 347495013238 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 347495013239 DNA-binding site [nucleotide binding]; DNA binding site 347495013240 RNA-binding motif; other site 347495013241 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 347495013242 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 347495013243 active site flap/lid [active] 347495013244 nucleophilic elbow; other site 347495013245 catalytic triad [active] 347495013246 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 347495013247 homodimer interface [polypeptide binding]; other site 347495013248 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 347495013249 active site pocket [active] 347495013250 glycogen synthase; Provisional; Region: glgA; PRK00654 347495013251 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 347495013252 ADP-binding pocket [chemical binding]; other site 347495013253 homodimer interface [polypeptide binding]; other site 347495013254 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 347495013255 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 347495013256 ligand binding site; other site 347495013257 oligomer interface; other site 347495013258 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 347495013259 dimer interface [polypeptide binding]; other site 347495013260 N-terminal domain interface [polypeptide binding]; other site 347495013261 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 347495013262 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 347495013263 ligand binding site; other site 347495013264 oligomer interface; other site 347495013265 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 347495013266 dimer interface [polypeptide binding]; other site 347495013267 N-terminal domain interface [polypeptide binding]; other site 347495013268 sulfate 1 binding site; other site 347495013269 glycogen branching enzyme; Provisional; Region: PRK12313 347495013270 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 347495013271 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 347495013272 active site 347495013273 catalytic site [active] 347495013274 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 347495013275 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 347495013276 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 347495013277 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 347495013278 putative active site [active] 347495013279 catalytic triad [active] 347495013280 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 347495013281 PA/protease domain interface [polypeptide binding]; other site 347495013282 putative integrin binding motif; other site 347495013283 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 347495013284 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 347495013285 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 347495013286 dockerin binding interface; other site 347495013287 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 347495013288 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 347495013289 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495013290 NAD binding site [chemical binding]; other site 347495013291 dimer interface [polypeptide binding]; other site 347495013292 substrate binding site [chemical binding]; other site 347495013293 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 347495013294 MgtC family; Region: MgtC; pfam02308 347495013295 Ion channel; Region: Ion_trans_2; pfam07885 347495013296 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 347495013297 TrkA-N domain; Region: TrkA_N; pfam02254 347495013298 YugN-like family; Region: YugN; pfam08868 347495013299 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 347495013300 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 347495013301 active site 347495013302 dimer interface [polypeptide binding]; other site 347495013303 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 347495013304 dimer interface [polypeptide binding]; other site 347495013305 active site 347495013306 Domain of unknown function (DUF378); Region: DUF378; pfam04070 347495013307 general stress protein 13; Validated; Region: PRK08059 347495013308 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 347495013309 RNA binding site [nucleotide binding]; other site 347495013310 hypothetical protein; Validated; Region: PRK07682 347495013311 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495013312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495013313 homodimer interface [polypeptide binding]; other site 347495013314 catalytic residue [active] 347495013315 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 347495013316 AsnC family; Region: AsnC_trans_reg; pfam01037 347495013317 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 347495013318 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 347495013319 dimerization interface [polypeptide binding]; other site 347495013320 ligand binding site [chemical binding]; other site 347495013321 NADP binding site [chemical binding]; other site 347495013322 catalytic site [active] 347495013323 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 347495013324 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 347495013325 nucleophilic elbow; other site 347495013326 catalytic triad; other site 347495013327 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 347495013328 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 347495013329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 347495013330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495013331 homodimer interface [polypeptide binding]; other site 347495013332 catalytic residue [active] 347495013333 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 347495013334 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 347495013335 E-class dimer interface [polypeptide binding]; other site 347495013336 P-class dimer interface [polypeptide binding]; other site 347495013337 active site 347495013338 Cu2+ binding site [ion binding]; other site 347495013339 Zn2+ binding site [ion binding]; other site 347495013340 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 347495013341 Kinase associated protein B; Region: KapB; pfam08810 347495013342 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 347495013343 active site 347495013344 catalytic site [active] 347495013345 substrate binding site [chemical binding]; other site 347495013346 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 347495013347 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 347495013348 transmembrane helices; other site 347495013349 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 347495013350 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 347495013351 active site 347495013352 glycyl-tRNA synthetase; Provisional; Region: PRK04173 347495013353 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 347495013354 motif 1; other site 347495013355 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 347495013356 active site 347495013357 motif 2; other site 347495013358 motif 3; other site 347495013359 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 347495013360 anticodon binding site; other site 347495013361 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 347495013362 CoenzymeA binding site [chemical binding]; other site 347495013363 subunit interaction site [polypeptide binding]; other site 347495013364 PHB binding site; other site 347495013365 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 347495013366 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 347495013367 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 347495013368 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 347495013369 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 347495013370 active site 347495013371 tetramer interface; other site 347495013372 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 347495013373 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 347495013374 active site 347495013375 substrate binding site [chemical binding]; other site 347495013376 metal binding site [ion binding]; metal-binding site 347495013377 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 347495013378 Uncharacterized conserved protein [Function unknown]; Region: COG1624 347495013379 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 347495013380 multifunctional aminopeptidase A; Provisional; Region: PRK00913 347495013381 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 347495013382 interface (dimer of trimers) [polypeptide binding]; other site 347495013383 Substrate-binding/catalytic site; other site 347495013384 Zn-binding sites [ion binding]; other site 347495013385 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 347495013386 Putative membrane protein; Region: YuiB; pfam14068 347495013387 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 347495013388 nudix motif; other site 347495013389 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 347495013390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495013391 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 347495013392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495013393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495013394 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013395 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013396 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013397 Domain of unknown function DUF11; Region: DUF11; pfam01345 347495013398 Domain of unknown function DUF11; Region: DUF11; pfam01345 347495013399 Domain of unknown function DUF11; Region: DUF11; pfam01345 347495013400 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013401 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013402 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013403 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013404 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013405 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013406 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013407 conserved repeat domain; Region: B_ant_repeat; TIGR01451 347495013408 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013409 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013410 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013411 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495013412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 347495013413 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495013414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495013415 putative substrate translocation pore; other site 347495013416 Helix-turn-helix domain; Region: HTH_36; pfam13730 347495013417 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 347495013418 Protein of unknown function (DUF523); Region: DUF523; pfam04463 347495013419 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 347495013420 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 347495013421 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 347495013422 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 347495013423 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 347495013424 hypothetical protein; Provisional; Region: PRK13669 347495013425 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 347495013426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495013427 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495013428 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 347495013429 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495013430 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495013431 Walker A/P-loop; other site 347495013432 ATP binding site [chemical binding]; other site 347495013433 Q-loop/lid; other site 347495013434 ABC transporter signature motif; other site 347495013435 Walker B; other site 347495013436 D-loop; other site 347495013437 H-loop/switch region; other site 347495013438 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 347495013439 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 347495013440 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 347495013441 PhnA protein; Region: PhnA; pfam03831 347495013442 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 347495013443 CAAX protease self-immunity; Region: Abi; pfam02517 347495013444 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 347495013445 active site 347495013446 NTP binding site [chemical binding]; other site 347495013447 metal binding triad [ion binding]; metal-binding site 347495013448 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 347495013449 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 347495013450 NifU-like domain; Region: NifU; pfam01106 347495013451 spore coat protein YutH; Region: spore_yutH; TIGR02905 347495013452 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 347495013453 tetramer interfaces [polypeptide binding]; other site 347495013454 binuclear metal-binding site [ion binding]; other site 347495013455 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 347495013456 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 347495013457 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 347495013458 FtsX-like permease family; Region: FtsX; pfam02687 347495013459 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 347495013460 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495013461 FtsX-like permease family; Region: FtsX; pfam02687 347495013462 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495013463 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495013464 Walker A/P-loop; other site 347495013465 ATP binding site [chemical binding]; other site 347495013466 Q-loop/lid; other site 347495013467 ABC transporter signature motif; other site 347495013468 Walker B; other site 347495013469 D-loop; other site 347495013470 H-loop/switch region; other site 347495013471 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 347495013472 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 347495013473 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 347495013474 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495013475 active site 347495013476 motif I; other site 347495013477 motif II; other site 347495013478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495013479 Predicted transcriptional regulator [Transcription]; Region: COG2345 347495013480 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495013481 putative Zn2+ binding site [ion binding]; other site 347495013482 putative DNA binding site [nucleotide binding]; other site 347495013483 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 347495013484 Uncharacterized conserved protein [Function unknown]; Region: COG2445 347495013485 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 347495013486 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 347495013487 putative active site [active] 347495013488 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 347495013489 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 347495013490 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495013491 RNA binding surface [nucleotide binding]; other site 347495013492 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 347495013493 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 347495013494 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 347495013495 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 347495013496 DNA binding residues [nucleotide binding] 347495013497 dimer interface [polypeptide binding]; other site 347495013498 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 347495013499 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 347495013500 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 347495013501 catalytic core [active] 347495013502 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 347495013503 putative deacylase active site [active] 347495013504 lipoyl synthase; Provisional; Region: PRK05481 347495013505 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 347495013506 FeS/SAM binding site; other site 347495013507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495013508 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495013509 sporulation protein YunB; Region: spo_yunB; TIGR02832 347495013510 Uncharacterized conserved protein [Function unknown]; Region: COG3377 347495013511 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 347495013512 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 347495013513 active site 347495013514 metal binding site [ion binding]; metal-binding site 347495013515 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 347495013516 Predicted transcriptional regulators [Transcription]; Region: COG1695 347495013517 Transcriptional regulator PadR-like family; Region: PadR; cl17335 347495013518 VanZ like family; Region: VanZ; pfam04892 347495013519 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 347495013520 FeS assembly protein SufB; Region: sufB; TIGR01980 347495013521 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 347495013522 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 347495013523 trimerization site [polypeptide binding]; other site 347495013524 active site 347495013525 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 347495013526 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 347495013527 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 347495013528 catalytic residue [active] 347495013529 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 347495013530 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 347495013531 FeS assembly protein SufD; Region: sufD; TIGR01981 347495013532 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 347495013533 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 347495013534 Walker A/P-loop; other site 347495013535 ATP binding site [chemical binding]; other site 347495013536 Q-loop/lid; other site 347495013537 ABC transporter signature motif; other site 347495013538 Walker B; other site 347495013539 D-loop; other site 347495013540 H-loop/switch region; other site 347495013541 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 347495013542 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 347495013543 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 347495013544 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 347495013545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 347495013546 ABC-ATPase subunit interface; other site 347495013547 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 347495013548 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 347495013549 Walker A/P-loop; other site 347495013550 ATP binding site [chemical binding]; other site 347495013551 Q-loop/lid; other site 347495013552 ABC transporter signature motif; other site 347495013553 Walker B; other site 347495013554 D-loop; other site 347495013555 H-loop/switch region; other site 347495013556 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 347495013557 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 347495013558 catalytic residues [active] 347495013559 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 347495013560 putative active site [active] 347495013561 putative metal binding site [ion binding]; other site 347495013562 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 347495013563 lipoyl attachment site [posttranslational modification]; other site 347495013564 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 347495013565 ArsC family; Region: ArsC; pfam03960 347495013566 putative ArsC-like catalytic residues; other site 347495013567 putative TRX-like catalytic residues [active] 347495013568 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 347495013569 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 347495013570 active site 347495013571 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 347495013572 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 347495013573 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 347495013574 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 347495013575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495013576 NAD binding site [chemical binding]; other site 347495013577 dimer interface [polypeptide binding]; other site 347495013578 substrate binding site [chemical binding]; other site 347495013579 Coat F domain; Region: Coat_F; pfam07875 347495013580 CAAX protease self-immunity; Region: Abi; pfam02517 347495013581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495013582 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495013583 WHG domain; Region: WHG; pfam13305 347495013584 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 347495013585 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 347495013586 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495013587 Walker A/P-loop; other site 347495013588 ATP binding site [chemical binding]; other site 347495013589 Q-loop/lid; other site 347495013590 ABC transporter signature motif; other site 347495013591 Walker B; other site 347495013592 D-loop; other site 347495013593 H-loop/switch region; other site 347495013594 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 347495013595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 347495013596 active site 347495013597 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 347495013598 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 347495013599 dimer interface [polypeptide binding]; other site 347495013600 active site 347495013601 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 347495013602 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 347495013603 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 347495013604 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 347495013605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 347495013606 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 347495013607 substrate binding site [chemical binding]; other site 347495013608 oxyanion hole (OAH) forming residues; other site 347495013609 YuzL-like protein; Region: YuzL; pfam14115 347495013610 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495013611 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 347495013612 Proline dehydrogenase; Region: Pro_dh; cl03282 347495013613 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 347495013614 Domain of unknown function DUF77; Region: DUF77; pfam01910 347495013615 Cache domain; Region: Cache_1; pfam02743 347495013616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495013617 dimerization interface [polypeptide binding]; other site 347495013618 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495013619 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495013620 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495013621 dimer interface [polypeptide binding]; other site 347495013622 putative CheW interface [polypeptide binding]; other site 347495013623 Predicted transcriptional regulators [Transcription]; Region: COG1378 347495013624 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 347495013625 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 347495013626 C-terminal domain interface [polypeptide binding]; other site 347495013627 sugar binding site [chemical binding]; other site 347495013628 TQXA domain; Region: TQXA_dom; TIGR03934 347495013629 Cna protein B-type domain; Region: Cna_B; pfam05738 347495013630 Cna protein B-type domain; Region: Cna_B; pfam05738 347495013631 Cna protein B-type domain; Region: Cna_B; pfam05738 347495013632 Cna protein B-type domain; Region: Cna_B; pfam05738 347495013633 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 347495013634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495013635 putative substrate translocation pore; other site 347495013636 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 347495013637 Spore germination protein; Region: Spore_permease; cl17796 347495013638 MAEBL; Provisional; Region: PTZ00121 347495013639 OxaA-like protein precursor; Validated; Region: PRK01622 347495013640 Uncharacterized conserved protein [Function unknown]; Region: COG1284 347495013641 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 347495013642 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 347495013643 hypothetical protein; Provisional; Region: PRK06758 347495013644 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 347495013645 active site 347495013646 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 347495013647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495013648 non-specific DNA binding site [nucleotide binding]; other site 347495013649 salt bridge; other site 347495013650 sequence-specific DNA binding site [nucleotide binding]; other site 347495013651 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 347495013652 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 347495013653 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 347495013654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 347495013655 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 347495013656 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495013657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495013658 active site 347495013659 phosphorylation site [posttranslational modification] 347495013660 intermolecular recognition site; other site 347495013661 dimerization interface [polypeptide binding]; other site 347495013662 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495013663 DNA binding site [nucleotide binding] 347495013664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 347495013665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495013666 dimer interface [polypeptide binding]; other site 347495013667 phosphorylation site [posttranslational modification] 347495013668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495013669 ATP binding site [chemical binding]; other site 347495013670 Mg2+ binding site [ion binding]; other site 347495013671 G-X-G motif; other site 347495013672 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 347495013673 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 347495013674 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 347495013675 active site 347495013676 HIGH motif; other site 347495013677 KMSKS motif; other site 347495013678 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 347495013679 tRNA binding surface [nucleotide binding]; other site 347495013680 anticodon binding site; other site 347495013681 Methyltransferase domain; Region: Methyltransf_23; pfam13489 347495013682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495013683 S-adenosylmethionine binding site [chemical binding]; other site 347495013684 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495013685 dimerization interface [polypeptide binding]; other site 347495013686 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495013687 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495013688 dimer interface [polypeptide binding]; other site 347495013689 putative CheW interface [polypeptide binding]; other site 347495013690 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495013691 dimerization interface [polypeptide binding]; other site 347495013692 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495013693 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495013694 dimer interface [polypeptide binding]; other site 347495013695 putative CheW interface [polypeptide binding]; other site 347495013696 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 347495013697 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 347495013698 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495013699 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 347495013700 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 347495013701 active site 347495013702 Zn binding site [ion binding]; other site 347495013703 Pirin-related protein [General function prediction only]; Region: COG1741 347495013704 Pirin; Region: Pirin; pfam02678 347495013705 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 347495013706 MarR family; Region: MarR_2; pfam12802 347495013707 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 347495013708 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 347495013709 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 347495013710 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 347495013711 TrkA-C domain; Region: TrkA_C; pfam02080 347495013712 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495013713 amino acid carrier protein; Region: agcS; TIGR00835 347495013714 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 347495013715 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 347495013716 dimerization interface [polypeptide binding]; other site 347495013717 DPS ferroxidase diiron center [ion binding]; other site 347495013718 ion pore; other site 347495013719 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 347495013720 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 347495013721 metal binding site [ion binding]; metal-binding site 347495013722 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 347495013723 Ferritin-like domain; Region: Ferritin; pfam00210 347495013724 ferroxidase diiron center [ion binding]; other site 347495013725 potential frameshift: common BLAST hit: gi|225867040|ref|YP_002752418.1| nucleoside transporter NupC family 347495013726 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495013727 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495013728 potential frameshift: common BLAST hit: gi|225867041|ref|YP_002752419.1| nucleoside transporter NupC family 347495013729 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495013730 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495013731 Nucleoside recognition; Region: Gate; pfam07670 347495013732 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495013733 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495013734 amino acid carrier protein; Region: agcS; TIGR00835 347495013735 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 347495013736 amino acid carrier protein; Region: agcS; TIGR00835 347495013737 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 347495013738 NADH(P)-binding; Region: NAD_binding_10; pfam13460 347495013739 NAD binding site [chemical binding]; other site 347495013740 substrate binding site [chemical binding]; other site 347495013741 putative active site [active] 347495013742 Peptidase M60-like family; Region: M60-like; pfam13402 347495013743 TQXA domain; Region: TQXA_dom; TIGR03934 347495013744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 347495013745 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 347495013746 active site 347495013747 catalytic tetrad [active] 347495013748 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 347495013749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495013750 putative substrate translocation pore; other site 347495013751 Predicted transcriptional regulators [Transcription]; Region: COG1733 347495013752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495013753 dimerization interface [polypeptide binding]; other site 347495013754 putative DNA binding site [nucleotide binding]; other site 347495013755 putative Zn2+ binding site [ion binding]; other site 347495013756 Uncharacterized conserved protein [Function unknown]; Region: COG2427 347495013757 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 347495013758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495013759 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 347495013760 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 347495013761 active site 347495013762 HIGH motif; other site 347495013763 dimer interface [polypeptide binding]; other site 347495013764 KMSKS motif; other site 347495013765 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 347495013766 RNA binding surface [nucleotide binding]; other site 347495013767 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 347495013768 FAD binding domain; Region: FAD_binding_4; pfam01565 347495013769 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 347495013770 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 347495013771 SET domain; Region: SET; pfam00856 347495013772 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 347495013773 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495013774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495013775 dimer interface [polypeptide binding]; other site 347495013776 putative CheW interface [polypeptide binding]; other site 347495013777 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 347495013778 putative catalytic site [active] 347495013779 putative metal binding site [ion binding]; other site 347495013780 putative phosphate binding site [ion binding]; other site 347495013781 camphor resistance protein CrcB; Provisional; Region: PRK14219 347495013782 camphor resistance protein CrcB; Provisional; Region: PRK14205 347495013783 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 347495013784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495013785 H+ Antiporter protein; Region: 2A0121; TIGR00900 347495013786 putative substrate translocation pore; other site 347495013787 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495013788 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495013789 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495013790 Domain of unknown function DUF87; Region: DUF87; pfam01935 347495013791 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495013792 ABC transporter; Region: ABC_tran_2; pfam12848 347495013793 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495013794 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 347495013795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 347495013796 Coenzyme A binding pocket [chemical binding]; other site 347495013797 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 347495013798 Nuclease-related domain; Region: NERD; pfam08378 347495013799 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 347495013800 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 347495013801 Walker A/P-loop; other site 347495013802 ATP binding site [chemical binding]; other site 347495013803 Q-loop/lid; other site 347495013804 ABC transporter signature motif; other site 347495013805 Walker B; other site 347495013806 D-loop; other site 347495013807 H-loop/switch region; other site 347495013808 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495013809 ABC-ATPase subunit interface; other site 347495013810 dimer interface [polypeptide binding]; other site 347495013811 putative PBP binding regions; other site 347495013812 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495013813 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495013814 ABC-ATPase subunit interface; other site 347495013815 dimer interface [polypeptide binding]; other site 347495013816 putative PBP binding regions; other site 347495013817 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 347495013818 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 347495013819 putative ligand binding residues [chemical binding]; other site 347495013820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495013821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495013822 active site 347495013823 phosphorylation site [posttranslational modification] 347495013824 intermolecular recognition site; other site 347495013825 dimerization interface [polypeptide binding]; other site 347495013826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495013827 DNA binding site [nucleotide binding] 347495013828 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 347495013829 SmpB-tmRNA interface; other site 347495013830 potential frameshift: common BLAST hit: gi|118480167|ref|YP_897318.1| ribonuclease R 347495013831 RNB domain; Region: RNB; pfam00773 347495013832 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 347495013833 RNA binding site [nucleotide binding]; other site 347495013834 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 347495013835 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 347495013836 RNB domain; Region: RNB; pfam00773 347495013837 Esterase/lipase [General function prediction only]; Region: COG1647 347495013838 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 347495013839 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 347495013840 holin-like protein; Validated; Region: PRK01658 347495013841 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 347495013842 active site 347495013843 enolase; Provisional; Region: eno; PRK00077 347495013844 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 347495013845 dimer interface [polypeptide binding]; other site 347495013846 metal binding site [ion binding]; metal-binding site 347495013847 substrate binding pocket [chemical binding]; other site 347495013848 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 347495013849 phosphoglyceromutase; Provisional; Region: PRK05434 347495013850 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 347495013851 triosephosphate isomerase; Provisional; Region: PRK14565 347495013852 substrate binding site [chemical binding]; other site 347495013853 dimer interface [polypeptide binding]; other site 347495013854 catalytic triad [active] 347495013855 Phosphoglycerate kinase; Region: PGK; pfam00162 347495013856 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 347495013857 substrate binding site [chemical binding]; other site 347495013858 hinge regions; other site 347495013859 ADP binding site [chemical binding]; other site 347495013860 catalytic site [active] 347495013861 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 347495013862 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 347495013863 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 347495013864 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 347495013865 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 347495013866 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 347495013867 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 347495013868 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 347495013869 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 347495013870 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 347495013871 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 347495013872 synthetase active site [active] 347495013873 NTP binding site [chemical binding]; other site 347495013874 metal binding site [ion binding]; metal-binding site 347495013875 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 347495013876 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 347495013877 stage V sporulation protein AD; Provisional; Region: PRK12404 347495013878 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 347495013879 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 347495013880 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 347495013881 Predicted membrane protein [Function unknown]; Region: COG2323 347495013882 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 347495013883 Clp protease; Region: CLP_protease; pfam00574 347495013884 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 347495013885 oligomer interface [polypeptide binding]; other site 347495013886 active site residues [active] 347495013887 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 347495013888 dimerization domain swap beta strand [polypeptide binding]; other site 347495013889 regulatory protein interface [polypeptide binding]; other site 347495013890 active site 347495013891 regulatory phosphorylation site [posttranslational modification]; other site 347495013892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 347495013893 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 347495013894 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 347495013895 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 347495013896 phosphate binding site [ion binding]; other site 347495013897 putative substrate binding pocket [chemical binding]; other site 347495013898 dimer interface [polypeptide binding]; other site 347495013899 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 347495013900 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 347495013901 putative active site [active] 347495013902 nucleotide binding site [chemical binding]; other site 347495013903 nudix motif; other site 347495013904 putative metal binding site [ion binding]; other site 347495013905 Domain of unknown function (DUF368); Region: DUF368; pfam04018 347495013906 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 347495013907 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 347495013908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 347495013909 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495013910 binding surface 347495013911 TPR motif; other site 347495013912 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495013913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 347495013914 binding surface 347495013915 Tetratricopeptide repeat; Region: TPR_16; pfam13432 347495013916 TPR motif; other site 347495013917 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 347495013918 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 347495013919 trimer interface [polypeptide binding]; other site 347495013920 active site 347495013921 substrate binding site [chemical binding]; other site 347495013922 CoA binding site [chemical binding]; other site 347495013923 pyrophosphatase PpaX; Provisional; Region: PRK13288 347495013924 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495013925 active site 347495013926 motif I; other site 347495013927 motif II; other site 347495013928 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 347495013929 HPr kinase/phosphorylase; Provisional; Region: PRK05428 347495013930 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 347495013931 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 347495013932 Hpr binding site; other site 347495013933 active site 347495013934 homohexamer subunit interaction site [polypeptide binding]; other site 347495013935 Predicted membrane protein [Function unknown]; Region: COG1950 347495013936 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 347495013937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 347495013938 HlyD family secretion protein; Region: HlyD_3; pfam13437 347495013939 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 347495013940 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 347495013941 putative active site [active] 347495013942 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495013943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495013944 Walker A/P-loop; other site 347495013945 ATP binding site [chemical binding]; other site 347495013946 Q-loop/lid; other site 347495013947 ABC transporter signature motif; other site 347495013948 Walker B; other site 347495013949 D-loop; other site 347495013950 H-loop/switch region; other site 347495013951 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 347495013952 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 347495013953 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 347495013954 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 347495013955 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 347495013956 excinuclease ABC subunit B; Provisional; Region: PRK05298 347495013957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495013958 ATP binding site [chemical binding]; other site 347495013959 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495013960 nucleotide binding region [chemical binding]; other site 347495013961 ATP-binding site [chemical binding]; other site 347495013962 Ultra-violet resistance protein B; Region: UvrB; pfam12344 347495013963 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 347495013964 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 347495013965 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495013966 DNA binding residues [nucleotide binding] 347495013967 dimer interface [polypeptide binding]; other site 347495013968 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 347495013969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495013970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495013971 non-specific DNA binding site [nucleotide binding]; other site 347495013972 salt bridge; other site 347495013973 sequence-specific DNA binding site [nucleotide binding]; other site 347495013974 Predicted membrane protein [Function unknown]; Region: COG2855 347495013975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495013976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495013977 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 347495013978 putative dimerization interface [polypeptide binding]; other site 347495013979 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 347495013980 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495013981 DNA binding residues [nucleotide binding] 347495013982 putative dimer interface [polypeptide binding]; other site 347495013983 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 347495013984 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 347495013985 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495013986 hypothetical protein; Provisional; Region: PRK12855 347495013987 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 347495013988 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 347495013989 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 347495013990 Walker A/P-loop; other site 347495013991 ATP binding site [chemical binding]; other site 347495013992 Q-loop/lid; other site 347495013993 ABC transporter signature motif; other site 347495013994 Walker B; other site 347495013995 D-loop; other site 347495013996 H-loop/switch region; other site 347495013997 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 347495013998 protein binding site [polypeptide binding]; other site 347495013999 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 347495014000 C-terminal peptidase (prc); Region: prc; TIGR00225 347495014001 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 347495014002 protein binding site [polypeptide binding]; other site 347495014003 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 347495014004 Catalytic dyad [active] 347495014005 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 347495014006 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 347495014007 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 347495014008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495014009 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 347495014010 Walker A/P-loop; other site 347495014011 ATP binding site [chemical binding]; other site 347495014012 Q-loop/lid; other site 347495014013 ABC transporter signature motif; other site 347495014014 Walker B; other site 347495014015 D-loop; other site 347495014016 H-loop/switch region; other site 347495014017 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 347495014018 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 347495014019 potential frameshift: common BLAST hit: gi|218906362|ref|YP_002454196.1| peptide chain release factor 2 347495014020 peptide chain release factor 2; Provisional; Region: PRK06746 347495014021 This domain is found in peptide chain release factors; Region: PCRF; smart00937 347495014022 RF-1 domain; Region: RF-1; pfam00472 347495014023 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 347495014024 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 347495014025 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 347495014026 nucleotide binding region [chemical binding]; other site 347495014027 ATP-binding site [chemical binding]; other site 347495014028 SEC-C motif; Region: SEC-C; pfam02810 347495014029 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 347495014030 30S subunit binding site; other site 347495014031 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 347495014032 DNA-binding site [nucleotide binding]; DNA binding site 347495014033 RNA-binding motif; other site 347495014034 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 347495014035 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495014036 active site 347495014037 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 347495014038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495014039 ATP binding site [chemical binding]; other site 347495014040 putative Mg++ binding site [ion binding]; other site 347495014041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495014042 nucleotide binding region [chemical binding]; other site 347495014043 ATP-binding site [chemical binding]; other site 347495014044 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 347495014045 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 347495014046 NlpC/P60 family; Region: NLPC_P60; pfam00877 347495014047 Predicted transcriptional regulators [Transcription]; Region: COG1733 347495014048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 347495014049 dimerization interface [polypeptide binding]; other site 347495014050 putative DNA binding site [nucleotide binding]; other site 347495014051 putative Zn2+ binding site [ion binding]; other site 347495014052 EDD domain protein, DegV family; Region: DegV; TIGR00762 347495014053 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 347495014054 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 347495014055 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 347495014056 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 347495014057 Transcriptional regulator [Transcription]; Region: LytR; COG1316 347495014058 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 347495014059 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 347495014060 active site 347495014061 homodimer interface [polypeptide binding]; other site 347495014062 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 347495014063 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 347495014064 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 347495014065 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 347495014066 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 347495014067 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 347495014068 Mg++ binding site [ion binding]; other site 347495014069 putative catalytic motif [active] 347495014070 substrate binding site [chemical binding]; other site 347495014071 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 347495014072 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 347495014073 NodB motif; other site 347495014074 active site 347495014075 catalytic site [active] 347495014076 Zn binding site [ion binding]; other site 347495014077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495014078 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 347495014079 Walker A motif; other site 347495014080 ATP binding site [chemical binding]; other site 347495014081 Walker B motif; other site 347495014082 arginine finger; other site 347495014083 Transcriptional antiterminator [Transcription]; Region: COG3933 347495014084 PRD domain; Region: PRD; pfam00874 347495014085 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 347495014086 active pocket/dimerization site; other site 347495014087 active site 347495014088 phosphorylation site [posttranslational modification] 347495014089 PRD domain; Region: PRD; pfam00874 347495014090 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 347495014091 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 347495014092 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 347495014093 Chromate transporter; Region: Chromate_transp; pfam02417 347495014094 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 347495014095 putative active site [active] 347495014096 YdjC motif; other site 347495014097 Mg binding site [ion binding]; other site 347495014098 putative homodimer interface [polypeptide binding]; other site 347495014099 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 347495014100 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 347495014101 NAD binding site [chemical binding]; other site 347495014102 sugar binding site [chemical binding]; other site 347495014103 divalent metal binding site [ion binding]; other site 347495014104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495014105 dimer interface [polypeptide binding]; other site 347495014106 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 347495014107 active site 347495014108 methionine cluster; other site 347495014109 phosphorylation site [posttranslational modification] 347495014110 metal binding site [ion binding]; metal-binding site 347495014111 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 347495014112 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 347495014113 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 347495014114 active site 347495014115 P-loop; other site 347495014116 phosphorylation site [posttranslational modification] 347495014117 spermidine synthase; Provisional; Region: PRK03612 347495014118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495014119 S-adenosylmethionine binding site [chemical binding]; other site 347495014120 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 347495014121 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 347495014122 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 347495014123 LytTr DNA-binding domain; Region: LytTR; smart00850 347495014124 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 347495014125 methionine cluster; other site 347495014126 active site 347495014127 phosphorylation site [posttranslational modification] 347495014128 metal binding site [ion binding]; metal-binding site 347495014129 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 347495014130 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 347495014131 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 347495014132 active site 347495014133 P-loop; other site 347495014134 phosphorylation site [posttranslational modification] 347495014135 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 347495014136 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 347495014137 Acyltransferase family; Region: Acyl_transf_3; pfam01757 347495014138 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 347495014139 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 347495014140 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 347495014141 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 347495014142 active site 347495014143 catalytic site [active] 347495014144 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014145 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495014146 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 347495014147 Domain of unknown function DUF11; Region: DUF11; pfam01345 347495014148 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495014149 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 347495014150 Domain of unknown function DUF11; Region: DUF11; cl17728 347495014151 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014152 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 347495014153 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 347495014154 Predicted membrane protein [Function unknown]; Region: COG1511 347495014155 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 347495014156 Transcriptional regulator [Transcription]; Region: LysR; COG0583 347495014157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 347495014158 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 347495014159 putative dimerization interface [polypeptide binding]; other site 347495014160 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 347495014161 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 347495014162 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 347495014163 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 347495014164 transmembrane helices; other site 347495014165 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 347495014166 ThiC-associated domain; Region: ThiC-associated; pfam13667 347495014167 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 347495014168 L-lactate permease; Region: Lactate_perm; cl00701 347495014169 glycolate transporter; Provisional; Region: PRK09695 347495014170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 347495014171 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 347495014172 Probable transposase; Region: OrfB_IS605; pfam01385 347495014173 Tic20-like protein; Region: Tic20; pfam09685 347495014174 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 347495014175 Uncharacterized conserved protein [Function unknown]; Region: COG3339 347495014176 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 347495014177 Sulfatase; Region: Sulfatase; pfam00884 347495014178 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 347495014179 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 347495014180 homodimer interface [polypeptide binding]; other site 347495014181 substrate-cofactor binding pocket; other site 347495014182 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495014183 catalytic residue [active] 347495014184 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014185 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014186 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014187 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014188 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014189 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 347495014190 NlpC/P60 family; Region: NLPC_P60; pfam00877 347495014191 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 347495014192 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 347495014193 Nucleoside recognition; Region: Gate; pfam07670 347495014194 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 347495014195 Uncharacterized conserved protein (DUF2215); Region: DUF2215; pfam10225 347495014196 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 347495014197 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 347495014198 DXD motif; other site 347495014199 BCCT family transporter; Region: BCCT; pfam02028 347495014200 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014201 Bacterial SH3 domain; Region: SH3_3; pfam08239 347495014202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 347495014203 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 347495014204 Predicted membrane protein [Function unknown]; Region: COG4640 347495014205 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 347495014206 Double zinc ribbon; Region: DZR; pfam12773 347495014207 Double zinc ribbon; Region: DZR; pfam12773 347495014208 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 347495014209 SNF2 Helicase protein; Region: DUF3670; pfam12419 347495014210 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 347495014211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 347495014212 ATP binding site [chemical binding]; other site 347495014213 putative Mg++ binding site [ion binding]; other site 347495014214 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 347495014215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495014216 nucleotide binding region [chemical binding]; other site 347495014217 ATP-binding site [chemical binding]; other site 347495014218 Predicted integral membrane protein [Function unknown]; Region: COG5652 347495014219 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 347495014220 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 347495014221 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 347495014222 ComK protein; Region: ComK; pfam06338 347495014223 RNA polymerase factor sigma-70; Validated; Region: PRK06759 347495014224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495014225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495014226 DNA binding residues [nucleotide binding] 347495014227 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 347495014228 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 347495014229 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 347495014230 FtsX-like permease family; Region: FtsX; pfam02687 347495014231 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 347495014232 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 347495014233 Walker A/P-loop; other site 347495014234 ATP binding site [chemical binding]; other site 347495014235 Q-loop/lid; other site 347495014236 ABC transporter signature motif; other site 347495014237 Walker B; other site 347495014238 D-loop; other site 347495014239 H-loop/switch region; other site 347495014240 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 347495014241 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 347495014242 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495014243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495014244 non-specific DNA binding site [nucleotide binding]; other site 347495014245 salt bridge; other site 347495014246 sequence-specific DNA binding site [nucleotide binding]; other site 347495014247 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 347495014248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495014249 putative substrate translocation pore; other site 347495014250 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 347495014251 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 347495014252 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 347495014253 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 347495014254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495014255 dimerization interface [polypeptide binding]; other site 347495014256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495014257 dimer interface [polypeptide binding]; other site 347495014258 phosphorylation site [posttranslational modification] 347495014259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495014260 ATP binding site [chemical binding]; other site 347495014261 Mg2+ binding site [ion binding]; other site 347495014262 G-X-G motif; other site 347495014263 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495014264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014265 active site 347495014266 phosphorylation site [posttranslational modification] 347495014267 intermolecular recognition site; other site 347495014268 dimerization interface [polypeptide binding]; other site 347495014269 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495014270 DNA binding site [nucleotide binding] 347495014271 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 347495014272 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 347495014273 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 347495014274 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 347495014275 active site 347495014276 P-loop; other site 347495014277 phosphorylation site [posttranslational modification] 347495014278 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 347495014279 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 347495014280 active site 347495014281 phosphorylation site [posttranslational modification] 347495014282 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 347495014283 HTH domain; Region: HTH_11; pfam08279 347495014284 HTH domain; Region: HTH_11; pfam08279 347495014285 PRD domain; Region: PRD; pfam00874 347495014286 PRD domain; Region: PRD; pfam00874 347495014287 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 347495014288 active site 347495014289 P-loop; other site 347495014290 phosphorylation site [posttranslational modification] 347495014291 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 347495014292 active site 347495014293 phosphorylation site [posttranslational modification] 347495014294 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 347495014295 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 347495014296 NAD binding site [chemical binding]; other site 347495014297 homodimer interface [polypeptide binding]; other site 347495014298 active site 347495014299 substrate binding site [chemical binding]; other site 347495014300 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 347495014301 active site 347495014302 catalytic triad [active] 347495014303 oxyanion hole [active] 347495014304 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 347495014305 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 347495014306 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 347495014307 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 347495014308 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 347495014309 active site 347495014310 Cupin domain; Region: Cupin_2; cl17218 347495014311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 347495014312 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 347495014313 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 347495014314 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 347495014315 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 347495014316 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 347495014317 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 347495014318 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 347495014319 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 347495014320 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 347495014321 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 347495014322 colanic acid exporter; Provisional; Region: PRK10459 347495014323 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 347495014324 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 347495014325 Bacterial sugar transferase; Region: Bac_transf; pfam02397 347495014326 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 347495014327 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 347495014328 active site 347495014329 tetramer interface; other site 347495014330 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 347495014331 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 347495014332 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 347495014333 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 347495014334 Chain length determinant protein; Region: Wzz; cl15801 347495014335 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 347495014336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 347495014337 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 347495014338 rod shape-determining protein Mbl; Provisional; Region: PRK13928 347495014339 MreB and similar proteins; Region: MreB_like; cd10225 347495014340 nucleotide binding site [chemical binding]; other site 347495014341 Mg binding site [ion binding]; other site 347495014342 putative protofilament interaction site [polypeptide binding]; other site 347495014343 RodZ interaction site [polypeptide binding]; other site 347495014344 Stage III sporulation protein D; Region: SpoIIID; cl17560 347495014345 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 347495014346 Peptidase family M23; Region: Peptidase_M23; pfam01551 347495014347 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495014348 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 347495014349 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495014350 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495014351 Walker A/P-loop; other site 347495014352 ATP binding site [chemical binding]; other site 347495014353 Q-loop/lid; other site 347495014354 ABC transporter signature motif; other site 347495014355 Walker B; other site 347495014356 D-loop; other site 347495014357 H-loop/switch region; other site 347495014358 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 347495014359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 347495014360 Walker A/P-loop; other site 347495014361 ATP binding site [chemical binding]; other site 347495014362 Q-loop/lid; other site 347495014363 ABC transporter signature motif; other site 347495014364 Walker B; other site 347495014365 D-loop; other site 347495014366 H-loop/switch region; other site 347495014367 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 347495014368 LytTr DNA-binding domain; Region: LytTR; pfam04397 347495014369 Stage II sporulation protein; Region: SpoIID; pfam08486 347495014370 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 347495014371 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 347495014372 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 347495014373 hinge; other site 347495014374 active site 347495014375 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 347495014376 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 347495014377 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 347495014378 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 347495014379 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 347495014380 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 347495014381 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 347495014382 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 347495014383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 347495014384 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 347495014385 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 347495014386 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 347495014387 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 347495014388 4Fe-4S binding domain; Region: Fer4; cl02805 347495014389 4Fe-4S binding domain; Region: Fer4; pfam00037 347495014390 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 347495014391 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 347495014392 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 347495014393 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 347495014394 NADH dehydrogenase subunit C; Validated; Region: PRK07735 347495014395 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 347495014396 NADH dehydrogenase subunit B; Validated; Region: PRK06411 347495014397 NADH dehydrogenase subunit A; Validated; Region: PRK07756 347495014398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495014399 PAS domain; Region: PAS_9; pfam13426 347495014400 putative active site [active] 347495014401 heme pocket [chemical binding]; other site 347495014402 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495014403 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495014404 metal binding site [ion binding]; metal-binding site 347495014405 active site 347495014406 I-site; other site 347495014407 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495014408 Protein of unknown function (DUF975); Region: DUF975; cl10504 347495014409 Protein of unknown function (DUF975); Region: DUF975; cl10504 347495014410 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 347495014411 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 347495014412 gamma subunit interface [polypeptide binding]; other site 347495014413 epsilon subunit interface [polypeptide binding]; other site 347495014414 LBP interface [polypeptide binding]; other site 347495014415 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 347495014416 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 347495014417 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 347495014418 alpha subunit interaction interface [polypeptide binding]; other site 347495014419 Walker A motif; other site 347495014420 ATP binding site [chemical binding]; other site 347495014421 Walker B motif; other site 347495014422 inhibitor binding site; inhibition site 347495014423 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 347495014424 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 347495014425 core domain interface [polypeptide binding]; other site 347495014426 delta subunit interface [polypeptide binding]; other site 347495014427 epsilon subunit interface [polypeptide binding]; other site 347495014428 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 347495014429 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 347495014430 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 347495014431 beta subunit interaction interface [polypeptide binding]; other site 347495014432 Walker A motif; other site 347495014433 ATP binding site [chemical binding]; other site 347495014434 Walker B motif; other site 347495014435 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 347495014436 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 347495014437 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 347495014438 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 347495014439 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 347495014440 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 347495014441 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 347495014442 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 347495014443 ATP synthase I chain; Region: ATP_synt_I; pfam03899 347495014444 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 347495014445 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 347495014446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 347495014447 active site 347495014448 potential frameshift: common BLAST hit: gi|301056783|ref|YP_003794994.1| serine hydroxymethyltransferase 347495014449 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 347495014450 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 347495014451 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 347495014452 dimer interface [polypeptide binding]; other site 347495014453 glycine-pyridoxal phosphate binding site [chemical binding]; other site 347495014454 active site 347495014455 folate binding site [chemical binding]; other site 347495014456 hypothetical protein; Provisional; Region: PRK13690 347495014457 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 347495014458 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 347495014459 Low molecular weight phosphatase family; Region: LMWPc; cd00115 347495014460 active site 347495014461 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 347495014462 HPr interaction site; other site 347495014463 glycerol kinase (GK) interaction site [polypeptide binding]; other site 347495014464 active site 347495014465 phosphorylation site [posttranslational modification] 347495014466 Predicted membrane protein [Function unknown]; Region: COG2259 347495014467 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 347495014468 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 347495014469 oligomer interface [polypeptide binding]; other site 347495014470 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 347495014471 Predicted membrane protein [Function unknown]; Region: COG1971 347495014472 Domain of unknown function DUF; Region: DUF204; pfam02659 347495014473 Domain of unknown function DUF; Region: DUF204; pfam02659 347495014474 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 347495014475 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 347495014476 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 347495014477 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 347495014478 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 347495014479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495014480 S-adenosylmethionine binding site [chemical binding]; other site 347495014481 peptide chain release factor 1; Validated; Region: prfA; PRK00591 347495014482 This domain is found in peptide chain release factors; Region: PCRF; smart00937 347495014483 RF-1 domain; Region: RF-1; pfam00472 347495014484 potential frameshift: common BLAST hit: gi|301056798|ref|YP_003795009.1| thymidine kinase 347495014485 thymidine kinase; Provisional; Region: PRK04296 347495014486 thymidine kinase; Provisional; Region: PRK04296 347495014487 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 347495014488 transcription termination factor Rho; Provisional; Region: rho; PRK09376 347495014489 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 347495014490 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 347495014491 RNA binding site [nucleotide binding]; other site 347495014492 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 347495014493 multimer interface [polypeptide binding]; other site 347495014494 Walker A motif; other site 347495014495 ATP binding site [chemical binding]; other site 347495014496 Walker B motif; other site 347495014497 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 347495014498 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 347495014499 putative active site [active] 347495014500 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 347495014501 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 347495014502 hinge; other site 347495014503 active site 347495014504 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 347495014505 active site 347495014506 zinc binding site [ion binding]; other site 347495014507 Na+ binding site [ion binding]; other site 347495014508 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 347495014509 intersubunit interface [polypeptide binding]; other site 347495014510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014511 Response regulator receiver domain; Region: Response_reg; pfam00072 347495014512 active site 347495014513 phosphorylation site [posttranslational modification] 347495014514 intermolecular recognition site; other site 347495014515 dimerization interface [polypeptide binding]; other site 347495014516 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 347495014517 CTP synthetase; Validated; Region: pyrG; PRK05380 347495014518 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 347495014519 Catalytic site [active] 347495014520 active site 347495014521 UTP binding site [chemical binding]; other site 347495014522 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 347495014523 active site 347495014524 putative oxyanion hole; other site 347495014525 catalytic triad [active] 347495014526 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 347495014527 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495014528 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495014529 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 347495014530 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 347495014531 FAD binding site [chemical binding]; other site 347495014532 homotetramer interface [polypeptide binding]; other site 347495014533 substrate binding pocket [chemical binding]; other site 347495014534 catalytic base [active] 347495014535 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 347495014536 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 347495014537 FAD binding site [chemical binding]; other site 347495014538 homotetramer interface [polypeptide binding]; other site 347495014539 substrate binding pocket [chemical binding]; other site 347495014540 catalytic base [active] 347495014541 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 347495014542 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 347495014543 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 347495014544 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 347495014545 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 347495014546 dimer interface [polypeptide binding]; other site 347495014547 active site 347495014548 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 347495014549 4Fe-4S binding domain; Region: Fer4; cl02805 347495014550 Cysteine-rich domain; Region: CCG; pfam02754 347495014551 Cysteine-rich domain; Region: CCG; pfam02754 347495014552 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 347495014553 PLD-like domain; Region: PLDc_2; pfam13091 347495014554 putative active site [active] 347495014555 catalytic site [active] 347495014556 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 347495014557 PLD-like domain; Region: PLDc_2; pfam13091 347495014558 putative active site [active] 347495014559 catalytic site [active] 347495014560 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 347495014561 PAS domain S-box; Region: sensory_box; TIGR00229 347495014562 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495014563 putative active site [active] 347495014564 heme pocket [chemical binding]; other site 347495014565 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495014566 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495014567 metal binding site [ion binding]; metal-binding site 347495014568 active site 347495014569 I-site; other site 347495014570 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 347495014571 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 347495014572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495014573 non-specific DNA binding site [nucleotide binding]; other site 347495014574 salt bridge; other site 347495014575 sequence-specific DNA binding site [nucleotide binding]; other site 347495014576 Tetratricopeptide repeat; Region: TPR_12; pfam13424 347495014577 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 347495014578 TPR motif; other site 347495014579 binding surface 347495014580 TPR repeat; Region: TPR_11; pfam13414 347495014581 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 347495014582 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495014583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014584 active site 347495014585 phosphorylation site [posttranslational modification] 347495014586 intermolecular recognition site; other site 347495014587 dimerization interface [polypeptide binding]; other site 347495014588 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495014589 DNA binding residues [nucleotide binding] 347495014590 dimerization interface [polypeptide binding]; other site 347495014591 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495014592 Histidine kinase; Region: HisKA_3; pfam07730 347495014593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495014594 Mg2+ binding site [ion binding]; other site 347495014595 G-X-G motif; other site 347495014596 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 347495014597 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 347495014598 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495014599 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 347495014600 Walker A/P-loop; other site 347495014601 ATP binding site [chemical binding]; other site 347495014602 Q-loop/lid; other site 347495014603 ABC transporter signature motif; other site 347495014604 Walker B; other site 347495014605 D-loop; other site 347495014606 H-loop/switch region; other site 347495014607 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 347495014608 active site 347495014609 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 347495014610 Collagen binding domain; Region: Collagen_bind; pfam05737 347495014611 Collagen binding domain; Region: Collagen_bind; pfam05737 347495014612 Collagen binding domain; Region: Collagen_bind; pfam05737 347495014613 Collagen binding domain; Region: Collagen_bind; pfam05737 347495014614 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014615 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014616 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014617 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014618 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014619 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014620 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014621 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 347495014622 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014623 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014624 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014625 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014626 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 347495014627 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014628 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014629 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014630 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014631 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014632 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014633 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 347495014634 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014635 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014636 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014637 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014638 Cna protein B-type domain; Region: Cna_B; pfam05738 347495014639 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 347495014640 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 347495014641 PA/protease or protease-like domain interface [polypeptide binding]; other site 347495014642 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 347495014643 Peptidase family M28; Region: Peptidase_M28; pfam04389 347495014644 metal binding site [ion binding]; metal-binding site 347495014645 RNA polymerase sigma factor; Provisional; Region: PRK12522 347495014646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 347495014647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 347495014648 DNA binding residues [nucleotide binding] 347495014649 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 347495014650 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 347495014651 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 347495014652 active site 347495014653 HIGH motif; other site 347495014654 KMSK motif region; other site 347495014655 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 347495014656 tRNA binding surface [nucleotide binding]; other site 347495014657 anticodon binding site; other site 347495014658 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 347495014659 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 347495014660 putative dimer interface [polypeptide binding]; other site 347495014661 catalytic triad [active] 347495014662 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 347495014663 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 347495014664 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 347495014665 agmatinase; Region: agmatinase; TIGR01230 347495014666 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 347495014667 putative active site [active] 347495014668 Mn binding site [ion binding]; other site 347495014669 spermidine synthase; Provisional; Region: PRK00811 347495014670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495014671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495014672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 347495014673 putative substrate translocation pore; other site 347495014674 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 347495014675 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 347495014676 DNA binding residues [nucleotide binding] 347495014677 putative dimer interface [polypeptide binding]; other site 347495014678 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 347495014679 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 347495014680 active site 347495014681 catalytic site [active] 347495014682 metal binding site [ion binding]; metal-binding site 347495014683 dimer interface [polypeptide binding]; other site 347495014684 Transglycosylase; Region: Transgly; pfam00912 347495014685 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 347495014686 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 347495014687 YwhD family; Region: YwhD; pfam08741 347495014688 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 347495014689 Peptidase family M50; Region: Peptidase_M50; pfam02163 347495014690 active site 347495014691 putative substrate binding region [chemical binding]; other site 347495014692 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 347495014693 active site 1 [active] 347495014694 dimer interface [polypeptide binding]; other site 347495014695 hexamer interface [polypeptide binding]; other site 347495014696 active site 2 [active] 347495014697 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 347495014698 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 347495014699 Zn2+ binding site [ion binding]; other site 347495014700 Mg2+ binding site [ion binding]; other site 347495014701 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 347495014702 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 347495014703 intersubunit interface [polypeptide binding]; other site 347495014704 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 347495014705 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 347495014706 Walker A/P-loop; other site 347495014707 ATP binding site [chemical binding]; other site 347495014708 Q-loop/lid; other site 347495014709 ABC transporter signature motif; other site 347495014710 Walker B; other site 347495014711 D-loop; other site 347495014712 H-loop/switch region; other site 347495014713 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495014714 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495014715 ABC-ATPase subunit interface; other site 347495014716 dimer interface [polypeptide binding]; other site 347495014717 putative PBP binding regions; other site 347495014718 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 347495014719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 347495014720 ABC-ATPase subunit interface; other site 347495014721 dimer interface [polypeptide binding]; other site 347495014722 putative PBP binding regions; other site 347495014723 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 347495014724 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 347495014725 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 347495014726 hypothetical protein; Provisional; Region: PRK12473 347495014727 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 347495014728 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 347495014729 putative heme peroxidase; Provisional; Region: PRK12276 347495014730 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 347495014731 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 347495014732 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 347495014733 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 347495014734 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 347495014735 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 347495014736 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 347495014737 Ion channel; Region: Ion_trans_2; pfam07885 347495014738 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 347495014739 TrkA-N domain; Region: TrkA_N; pfam02254 347495014740 TrkA-C domain; Region: TrkA_C; pfam02080 347495014741 putative uracil/xanthine transporter; Provisional; Region: PRK11412 347495014742 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 347495014743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495014744 motif II; other site 347495014745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495014746 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 347495014747 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 347495014748 ligand binding site [chemical binding]; other site 347495014749 active site 347495014750 UGI interface [polypeptide binding]; other site 347495014751 catalytic site [active] 347495014752 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 347495014753 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 347495014754 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 347495014755 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 347495014756 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 347495014757 Walker A/P-loop; other site 347495014758 ATP binding site [chemical binding]; other site 347495014759 Q-loop/lid; other site 347495014760 ABC transporter signature motif; other site 347495014761 Walker B; other site 347495014762 D-loop; other site 347495014763 H-loop/switch region; other site 347495014764 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 347495014765 active site 347495014766 catalytic triad [active] 347495014767 oxyanion hole [active] 347495014768 Transcriptional regulators [Transcription]; Region: PurR; COG1609 347495014769 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 347495014770 DNA binding site [nucleotide binding] 347495014771 domain linker motif; other site 347495014772 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 347495014773 putative dimerization interface [polypeptide binding]; other site 347495014774 putative ligand binding site [chemical binding]; other site 347495014775 Predicted membrane protein [Function unknown]; Region: COG2364 347495014776 homoserine dehydrogenase; Provisional; Region: PRK06349 347495014777 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 347495014778 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 347495014779 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 347495014780 homoserine O-succinyltransferase; Provisional; Region: PRK05368 347495014781 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 347495014782 proposed active site lysine [active] 347495014783 conserved cys residue [active] 347495014784 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 347495014785 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 347495014786 homodimer interface [polypeptide binding]; other site 347495014787 substrate-cofactor binding pocket; other site 347495014788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 347495014789 catalytic residue [active] 347495014790 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 347495014791 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 347495014792 active site 347495014793 motif I; other site 347495014794 motif II; other site 347495014795 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 347495014796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 347495014797 ligand binding site [chemical binding]; other site 347495014798 flexible hinge region; other site 347495014799 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 347495014800 azoreductase; Provisional; Region: PRK13556 347495014801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 347495014802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014803 active site 347495014804 phosphorylation site [posttranslational modification] 347495014805 intermolecular recognition site; other site 347495014806 dimerization interface [polypeptide binding]; other site 347495014807 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 347495014808 DNA binding residues [nucleotide binding] 347495014809 dimerization interface [polypeptide binding]; other site 347495014810 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 347495014811 GAF domain; Region: GAF; pfam01590 347495014812 GAF domain; Region: GAF_3; pfam13492 347495014813 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 347495014814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 347495014815 Histidine kinase; Region: HisKA_3; pfam07730 347495014816 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 347495014817 ATP binding site [chemical binding]; other site 347495014818 Mg2+ binding site [ion binding]; other site 347495014819 G-X-G motif; other site 347495014820 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 347495014821 dimer interface [polypeptide binding]; other site 347495014822 substrate binding site [chemical binding]; other site 347495014823 ATP binding site [chemical binding]; other site 347495014824 potential frameshift: common BLAST hit: gi|218906595|ref|YP_002454429.1| GGDEF domain protein 347495014825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495014826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495014827 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 347495014828 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 347495014829 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 347495014830 metal binding site [ion binding]; metal-binding site 347495014831 active site 347495014832 I-site; other site 347495014833 Protein of unknown function (DUF466); Region: DUF466; pfam04328 347495014834 carbon starvation protein A; Provisional; Region: PRK15015 347495014835 Carbon starvation protein CstA; Region: CstA; pfam02554 347495014836 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 347495014837 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 347495014838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014839 active site 347495014840 phosphorylation site [posttranslational modification] 347495014841 intermolecular recognition site; other site 347495014842 dimerization interface [polypeptide binding]; other site 347495014843 LytTr DNA-binding domain; Region: LytTR; pfam04397 347495014844 benzoate transport; Region: 2A0115; TIGR00895 347495014845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495014846 putative substrate translocation pore; other site 347495014847 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 347495014848 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 347495014849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 347495014850 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 347495014851 Predicted membrane protein [Function unknown]; Region: COG2860 347495014852 UPF0126 domain; Region: UPF0126; pfam03458 347495014853 UPF0126 domain; Region: UPF0126; pfam03458 347495014854 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 347495014855 heme-binding site [chemical binding]; other site 347495014856 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 347495014857 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 347495014858 dimer interface [polypeptide binding]; other site 347495014859 putative CheW interface [polypeptide binding]; other site 347495014860 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 347495014861 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 347495014862 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 347495014863 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 347495014864 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 347495014865 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 347495014866 active site 347495014867 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 347495014868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495014869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495014870 ABC transporter; Region: ABC_tran_2; pfam12848 347495014871 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 347495014872 conserved hypothetical integral membrane protein; Region: TIGR03766 347495014873 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 347495014874 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 347495014875 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 347495014876 Ligand binding site; other site 347495014877 Putative Catalytic site; other site 347495014878 DXD motif; other site 347495014879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 347495014880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 347495014881 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 347495014882 Protein export membrane protein; Region: SecD_SecF; cl14618 347495014883 methionine sulfoxide reductase A; Provisional; Region: PRK14054 347495014884 methionine sulfoxide reductase B; Provisional; Region: PRK00222 347495014885 SelR domain; Region: SelR; pfam01641 347495014886 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 347495014887 antiholin-like protein LrgB; Provisional; Region: PRK04288 347495014888 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 347495014889 two-component response regulator; Provisional; Region: PRK14084 347495014890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014891 active site 347495014892 phosphorylation site [posttranslational modification] 347495014893 intermolecular recognition site; other site 347495014894 dimerization interface [polypeptide binding]; other site 347495014895 LytTr DNA-binding domain; Region: LytTR; pfam04397 347495014896 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 347495014897 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 347495014898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 347495014899 Histidine kinase; Region: His_kinase; pfam06580 347495014900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495014901 ATP binding site [chemical binding]; other site 347495014902 Mg2+ binding site [ion binding]; other site 347495014903 G-X-G motif; other site 347495014904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 347495014905 benzoate transport; Region: 2A0115; TIGR00895 347495014906 putative substrate translocation pore; other site 347495014907 BCCT family transporter; Region: BCCT; pfam02028 347495014908 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 347495014909 active site 347495014910 dimer interface [polypeptide binding]; other site 347495014911 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 347495014912 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 347495014913 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 347495014914 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 347495014915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 347495014916 NAD(P) binding site [chemical binding]; other site 347495014917 active site 347495014918 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 347495014919 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 347495014920 UDP-glucose 4-epimerase; Region: PLN02240 347495014921 NAD binding site [chemical binding]; other site 347495014922 homodimer interface [polypeptide binding]; other site 347495014923 active site 347495014924 substrate binding site [chemical binding]; other site 347495014925 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 347495014926 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 347495014927 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 347495014928 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 347495014929 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 347495014930 ATP binding site [chemical binding]; other site 347495014931 Mg++ binding site [ion binding]; other site 347495014932 motif III; other site 347495014933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 347495014934 nucleotide binding region [chemical binding]; other site 347495014935 ATP-binding site [chemical binding]; other site 347495014936 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 347495014937 RNA binding site [nucleotide binding]; other site 347495014938 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 347495014939 Acyltransferase family; Region: Acyl_transf_3; pfam01757 347495014940 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 347495014941 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 347495014942 active site 347495014943 oligoendopeptidase F; Region: pepF; TIGR00181 347495014944 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 347495014945 active site 347495014946 Zn binding site [ion binding]; other site 347495014947 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 347495014948 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 347495014949 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 347495014950 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 347495014951 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 347495014952 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 347495014953 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 347495014954 protein binding site [polypeptide binding]; other site 347495014955 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 347495014956 YycH protein; Region: YycI; pfam09648 347495014957 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 347495014958 YycH protein; Region: YycH; pfam07435 347495014959 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 347495014960 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 347495014961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 347495014962 dimerization interface [polypeptide binding]; other site 347495014963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 347495014964 putative active site [active] 347495014965 heme pocket [chemical binding]; other site 347495014966 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 347495014967 dimer interface [polypeptide binding]; other site 347495014968 phosphorylation site [posttranslational modification] 347495014969 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 347495014970 ATP binding site [chemical binding]; other site 347495014971 Mg2+ binding site [ion binding]; other site 347495014972 G-X-G motif; other site 347495014973 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 347495014974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 347495014975 active site 347495014976 phosphorylation site [posttranslational modification] 347495014977 intermolecular recognition site; other site 347495014978 dimerization interface [polypeptide binding]; other site 347495014979 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 347495014980 DNA binding site [nucleotide binding] 347495014981 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 347495014982 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 347495014983 GDP-binding site [chemical binding]; other site 347495014984 ACT binding site; other site 347495014985 IMP binding site; other site 347495014986 replicative DNA helicase; Provisional; Region: PRK05748 347495014987 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 347495014988 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 347495014989 Walker A motif; other site 347495014990 ATP binding site [chemical binding]; other site 347495014991 Walker B motif; other site 347495014992 DNA binding loops [nucleotide binding] 347495014993 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 347495014994 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 347495014995 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 347495014996 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 347495014997 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 347495014998 DHH family; Region: DHH; pfam01368 347495014999 DHHA1 domain; Region: DHHA1; pfam02272 347495015000 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 347495015001 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 347495015002 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 347495015003 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 347495015004 dimer interface [polypeptide binding]; other site 347495015005 ssDNA binding site [nucleotide binding]; other site 347495015006 tetramer (dimer of dimers) interface [polypeptide binding]; other site 347495015007 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 347495015008 GTP-binding protein YchF; Reviewed; Region: PRK09601 347495015009 YchF GTPase; Region: YchF; cd01900 347495015010 G1 box; other site 347495015011 GTP/Mg2+ binding site [chemical binding]; other site 347495015012 Switch I region; other site 347495015013 G2 box; other site 347495015014 Switch II region; other site 347495015015 G3 box; other site 347495015016 G4 box; other site 347495015017 G5 box; other site 347495015018 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 347495015019 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 347495015020 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 347495015021 Mechanosensitive ion channel; Region: MS_channel; pfam00924 347495015022 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 347495015023 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 347495015024 ParB-like nuclease domain; Region: ParB; smart00470 347495015025 KorB domain; Region: KorB; pfam08535 347495015026 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 347495015027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 347495015028 P-loop; other site 347495015029 Magnesium ion binding site [ion binding]; other site 347495015030 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 347495015031 Magnesium ion binding site [ion binding]; other site 347495015032 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 347495015033 ParB-like nuclease domain; Region: ParBc; pfam02195 347495015034 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 347495015035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 347495015036 S-adenosylmethionine binding site [chemical binding]; other site 347495015037 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 347495015038 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 347495015039 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 347495015040 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 347495015041 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 347495015042 trmE is a tRNA modification GTPase; Region: trmE; cd04164 347495015043 G1 box; other site 347495015044 GTP/Mg2+ binding site [chemical binding]; other site 347495015045 Switch I region; other site 347495015046 G2 box; other site 347495015047 Switch II region; other site 347495015048 G3 box; other site 347495015049 G4 box; other site 347495015050 G5 box; other site 347495015051 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 347495015052 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 347495015053 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 347495015054 G-X-X-G motif; other site 347495015055 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 347495015056 RxxxH motif; other site 347495015057 OxaA-like protein precursor; Validated; Region: PRK02944 347495015058 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 347495015059 ribonuclease P; Reviewed; Region: rnpA; PRK00499 347495015060 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 347495015061 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 347495015062 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 347495015063 active site 347495015064 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 347495015065 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 347495015066 DNA binding residues [nucleotide binding] 347495015067 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 347495015068 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 347495015069 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 347495015070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495015071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495015072 non-specific DNA binding site [nucleotide binding]; other site 347495015073 salt bridge; other site 347495015074 sequence-specific DNA binding site [nucleotide binding]; other site 347495015075 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 347495015076 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 347495015077 Recombination protein U; Region: RecU; pfam03838 347495015078 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 347495015079 trimer interface [polypeptide binding]; other site 347495015080 active site 347495015081 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 347495015082 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 347495015083 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 347495015084 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 347495015085 Walker A motif; other site 347495015086 ATP binding site [chemical binding]; other site 347495015087 Walker B motif; other site 347495015088 arginine finger; other site 347495015089 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 347495015090 ERF superfamily; Region: ERF; pfam04404 347495015091 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 347495015092 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 347495015093 Prophage antirepressor [Transcription]; Region: COG3617 347495015094 BRO family, N-terminal domain; Region: Bro-N; smart01040 347495015095 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 347495015096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495015097 non-specific DNA binding site [nucleotide binding]; other site 347495015098 salt bridge; other site 347495015099 sequence-specific DNA binding site [nucleotide binding]; other site 347495015100 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495015101 non-specific DNA binding site [nucleotide binding]; other site 347495015102 salt bridge; other site 347495015103 sequence-specific DNA binding site [nucleotide binding]; other site 347495015104 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 347495015105 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 347495015106 non-specific DNA binding site [nucleotide binding]; other site 347495015107 salt bridge; other site 347495015108 sequence-specific DNA binding site [nucleotide binding]; other site 347495015109 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 347495015110 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 347495015111 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 347495015112 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 347495015113 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 347495015114 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 347495015115 P-loop; other site 347495015116 Magnesium ion binding site [ion binding]; other site 347495015117 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 347495015118 Magnesium ion binding site [ion binding]; other site 347495015119 Uncharacterized conserved protein [Function unknown]; Region: COG5276 347495015120 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 347495015121 putative catalytic site [active] 347495015122 putative phosphate binding site [ion binding]; other site 347495015123 putative metal binding site [ion binding]; other site 347495015124 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 347495015125 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 347495015126 DNA binding residues [nucleotide binding] 347495015127 DNA polymerase IV; Reviewed; Region: PRK03103 347495015128 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 347495015129 active site 347495015130 DNA binding site [nucleotide binding] 347495015131 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 347495015132 YolD-like protein; Region: YolD; pfam08863 347495015133 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 347495015134 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 347495015135 active site 347495015136 metal binding site [ion binding]; metal-binding site 347495015137 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 347495015138 Holin family; Region: Phage_holin_4; pfam05105 347495015139 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 347495015140 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 347495015141 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 347495015142 Phage tail protein; Region: Sipho_tail; pfam05709 347495015143 Phage-related protein [Function unknown]; Region: COG5412 347495015144 Phage protein; Region: DUF3647; pfam12363 347495015145 Phage major tail protein 2; Region: Phage_tail_2; cl11463 347495015146 Domain of unknown function (DUF3599); Region: DUF3599; pfam12206 347495015147 Putative Head-Tail Connector Protein Yqbg from Bacillus subtilis and similar proteins; Region: Yqbg; cd08053 347495015148 Phage capsid family; Region: Phage_capsid; pfam05065 347495015149 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 347495015150 Phage-related protein [Function unknown]; Region: COG4695; cl01923 347495015151 Phage terminase large subunit; Region: Terminase_3; cl12054 347495015152 Terminase-like family; Region: Terminase_6; pfam03237 347495015153 Uncharacterized conserved protein [Function unknown]; Region: COG5484 347495015154 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056