-- dump date 20140618_221029 -- class Genbank::misc_feature -- table misc_feature_note -- id note 405531000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 405531000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405531000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531000004 Walker A motif; other site 405531000005 ATP binding site [chemical binding]; other site 405531000006 Walker B motif; other site 405531000007 arginine finger; other site 405531000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 405531000009 DnaA box-binding interface [nucleotide binding]; other site 405531000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 405531000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405531000012 putative DNA binding surface [nucleotide binding]; other site 405531000013 dimer interface [polypeptide binding]; other site 405531000014 beta-clamp/clamp loader binding surface; other site 405531000015 beta-clamp/translesion DNA polymerase binding surface; other site 405531000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 405531000017 recombination protein F; Reviewed; Region: recF; PRK00064 405531000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 405531000019 Walker A/P-loop; other site 405531000020 ATP binding site [chemical binding]; other site 405531000021 Q-loop/lid; other site 405531000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531000023 ABC transporter signature motif; other site 405531000024 Walker B; other site 405531000025 D-loop; other site 405531000026 H-loop/switch region; other site 405531000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405531000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531000029 Mg2+ binding site [ion binding]; other site 405531000030 G-X-G motif; other site 405531000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405531000032 anchoring element; other site 405531000033 dimer interface [polypeptide binding]; other site 405531000034 ATP binding site [chemical binding]; other site 405531000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405531000036 active site 405531000037 putative metal-binding site [ion binding]; other site 405531000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405531000039 DNA gyrase subunit A; Validated; Region: PRK05560 405531000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405531000041 CAP-like domain; other site 405531000042 active site 405531000043 primary dimer interface [polypeptide binding]; other site 405531000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531000050 YaaC-like Protein; Region: YaaC; pfam14175 405531000051 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 405531000052 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405531000053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 405531000054 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405531000055 active site 405531000056 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405531000057 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531000058 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405531000059 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 405531000060 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 405531000061 active site 405531000062 multimer interface [polypeptide binding]; other site 405531000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 405531000064 predicted active site [active] 405531000065 catalytic triad [active] 405531000066 seryl-tRNA synthetase; Provisional; Region: PRK05431 405531000067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405531000068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405531000069 dimer interface [polypeptide binding]; other site 405531000070 active site 405531000071 motif 1; other site 405531000072 motif 2; other site 405531000073 motif 3; other site 405531000074 Domain of unknown function (DUF3797); Region: DUF3797; pfam12677 405531000075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 405531000076 DNA binding residues [nucleotide binding] 405531000077 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405531000078 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405531000079 Substrate-binding site [chemical binding]; other site 405531000080 Substrate specificity [chemical binding]; other site 405531000081 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 405531000082 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 405531000083 Substrate-binding site [chemical binding]; other site 405531000084 Substrate specificity [chemical binding]; other site 405531000085 Isochorismatase family; Region: Isochorismatase; pfam00857 405531000086 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405531000087 catalytic triad [active] 405531000088 conserved cis-peptide bond; other site 405531000089 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 405531000090 nucleoside/Zn binding site; other site 405531000091 dimer interface [polypeptide binding]; other site 405531000092 catalytic motif [active] 405531000093 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 405531000094 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531000095 Walker A motif; other site 405531000096 ATP binding site [chemical binding]; other site 405531000097 Walker B motif; other site 405531000098 arginine finger; other site 405531000099 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 405531000100 hypothetical protein; Validated; Region: PRK00153 405531000101 recombination protein RecR; Reviewed; Region: recR; PRK00076 405531000102 RecR protein; Region: RecR; pfam02132 405531000103 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 405531000104 putative active site [active] 405531000105 putative metal-binding site [ion binding]; other site 405531000106 tetramer interface [polypeptide binding]; other site 405531000107 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 405531000108 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 405531000109 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 405531000110 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405531000111 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405531000112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531000113 catalytic residue [active] 405531000114 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405531000115 thymidylate kinase; Validated; Region: tmk; PRK00698 405531000116 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405531000117 TMP-binding site; other site 405531000118 ATP-binding site [chemical binding]; other site 405531000119 DNA polymerase III subunit delta'; Validated; Region: PRK08058 405531000120 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 405531000121 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 405531000122 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 405531000123 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531000124 S-adenosylmethionine binding site [chemical binding]; other site 405531000125 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 405531000126 putative active site [active] 405531000127 GIY-YIG motif/motif A; other site 405531000128 putative metal binding site [ion binding]; other site 405531000129 Predicted methyltransferases [General function prediction only]; Region: COG0313 405531000130 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 405531000131 putative SAM binding site [chemical binding]; other site 405531000132 putative homodimer interface [polypeptide binding]; other site 405531000133 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405531000134 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405531000135 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 405531000136 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405531000137 active site 405531000138 HIGH motif; other site 405531000139 KMSKS motif; other site 405531000140 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405531000141 tRNA binding surface [nucleotide binding]; other site 405531000142 anticodon binding site; other site 405531000143 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 405531000144 dimer interface [polypeptide binding]; other site 405531000145 putative tRNA-binding site [nucleotide binding]; other site 405531000146 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405531000147 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405531000148 active site 405531000149 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 405531000150 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405531000151 putative active site [active] 405531000152 putative metal binding site [ion binding]; other site 405531000153 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 405531000154 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 405531000155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531000156 S-adenosylmethionine binding site [chemical binding]; other site 405531000157 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 405531000158 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 405531000159 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531000160 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 405531000161 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405531000162 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405531000163 pur operon repressor; Provisional; Region: PRK09213 405531000164 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 405531000165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531000166 active site 405531000167 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405531000168 homotrimer interaction site [polypeptide binding]; other site 405531000169 putative active site [active] 405531000170 regulatory protein SpoVG; Reviewed; Region: PRK13259 405531000171 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 405531000172 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 405531000173 Substrate binding site; other site 405531000174 Mg++ binding site; other site 405531000175 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 405531000176 active site 405531000177 substrate binding site [chemical binding]; other site 405531000178 CoA binding site [chemical binding]; other site 405531000179 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405531000180 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405531000181 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531000182 active site 405531000183 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 405531000184 putative active site [active] 405531000185 catalytic residue [active] 405531000186 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 405531000187 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 405531000188 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 405531000189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531000190 ATP binding site [chemical binding]; other site 405531000191 putative Mg++ binding site [ion binding]; other site 405531000192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531000193 nucleotide binding region [chemical binding]; other site 405531000194 ATP-binding site [chemical binding]; other site 405531000195 TRCF domain; Region: TRCF; pfam03461 405531000196 stage V sporulation protein T; Region: spore_V_T; TIGR02851 405531000197 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 405531000198 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405531000199 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 405531000200 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 405531000201 putative SAM binding site [chemical binding]; other site 405531000202 putative homodimer interface [polypeptide binding]; other site 405531000203 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 405531000204 homodimer interface [polypeptide binding]; other site 405531000205 metal binding site [ion binding]; metal-binding site 405531000206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 405531000207 homodimer interface [polypeptide binding]; other site 405531000208 active site 405531000209 putative chemical substrate binding site [chemical binding]; other site 405531000210 metal binding site [ion binding]; metal-binding site 405531000211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531000212 RNA binding surface [nucleotide binding]; other site 405531000213 sporulation protein YabP; Region: spore_yabP; TIGR02892 405531000214 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 405531000215 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405531000216 Septum formation initiator; Region: DivIC; pfam04977 405531000217 hypothetical protein; Provisional; Region: PRK08582 405531000218 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405531000219 RNA binding site [nucleotide binding]; other site 405531000220 stage II sporulation protein E; Region: spore_II_E; TIGR02865 405531000221 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405531000222 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 405531000223 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 405531000224 Ligand Binding Site [chemical binding]; other site 405531000225 TilS substrate binding domain; Region: TilS; pfam09179 405531000226 TilS substrate C-terminal domain; Region: TilS_C; smart00977 405531000227 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531000228 active site 405531000229 FtsH Extracellular; Region: FtsH_ext; pfam06480 405531000230 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 405531000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531000232 Walker A motif; other site 405531000233 ATP binding site [chemical binding]; other site 405531000234 Walker B motif; other site 405531000235 arginine finger; other site 405531000236 Peptidase family M41; Region: Peptidase_M41; pfam01434 405531000237 pantothenate kinase; Reviewed; Region: PRK13318 405531000238 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 405531000239 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 405531000240 dimerization interface [polypeptide binding]; other site 405531000241 domain crossover interface; other site 405531000242 redox-dependent activation switch; other site 405531000243 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405531000244 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405531000245 dimer interface [polypeptide binding]; other site 405531000246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531000247 catalytic residue [active] 405531000248 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 405531000249 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405531000250 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405531000251 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405531000252 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405531000253 glutamine binding [chemical binding]; other site 405531000254 catalytic triad [active] 405531000255 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405531000256 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 405531000257 homodimer interface [polypeptide binding]; other site 405531000258 substrate-cofactor binding pocket; other site 405531000259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531000260 catalytic residue [active] 405531000261 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 405531000262 dihydropteroate synthase; Region: DHPS; TIGR01496 405531000263 substrate binding pocket [chemical binding]; other site 405531000264 dimer interface [polypeptide binding]; other site 405531000265 inhibitor binding site; inhibition site 405531000266 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 405531000267 homooctamer interface [polypeptide binding]; other site 405531000268 active site 405531000269 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 405531000270 catalytic center binding site [active] 405531000271 ATP binding site [chemical binding]; other site 405531000272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531000273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531000274 non-specific DNA binding site [nucleotide binding]; other site 405531000275 salt bridge; other site 405531000276 sequence-specific DNA binding site [nucleotide binding]; other site 405531000277 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 405531000278 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405531000279 FMN binding site [chemical binding]; other site 405531000280 active site 405531000281 catalytic residues [active] 405531000282 substrate binding site [chemical binding]; other site 405531000283 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 405531000284 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405531000285 dimer interface [polypeptide binding]; other site 405531000286 putative anticodon binding site; other site 405531000287 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405531000288 motif 1; other site 405531000289 active site 405531000290 motif 2; other site 405531000291 motif 3; other site 405531000292 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 405531000293 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 405531000294 UvrB/uvrC motif; Region: UVR; pfam02151 405531000295 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 405531000296 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 405531000297 ADP binding site [chemical binding]; other site 405531000298 phosphagen binding site; other site 405531000299 substrate specificity loop; other site 405531000300 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 405531000301 Clp amino terminal domain; Region: Clp_N; pfam02861 405531000302 Clp amino terminal domain; Region: Clp_N; pfam02861 405531000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531000304 Walker A motif; other site 405531000305 ATP binding site [chemical binding]; other site 405531000306 Walker B motif; other site 405531000307 arginine finger; other site 405531000308 UvrB/uvrC motif; Region: UVR; pfam02151 405531000309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531000310 Walker A motif; other site 405531000311 ATP binding site [chemical binding]; other site 405531000312 Walker B motif; other site 405531000313 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405531000314 DNA repair protein RadA; Provisional; Region: PRK11823 405531000315 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 405531000316 Walker A motif/ATP binding site; other site 405531000317 ATP binding site [chemical binding]; other site 405531000318 Walker B motif; other site 405531000319 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405531000320 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 405531000321 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405531000322 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 405531000323 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 405531000324 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 405531000325 putative active site [active] 405531000326 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 405531000327 substrate binding site; other site 405531000328 dimer interface; other site 405531000329 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 405531000330 homotrimer interaction site [polypeptide binding]; other site 405531000331 zinc binding site [ion binding]; other site 405531000332 CDP-binding sites; other site 405531000333 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 405531000334 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405531000335 HIGH motif; other site 405531000336 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405531000337 active site 405531000338 KMSKS motif; other site 405531000339 serine O-acetyltransferase; Region: cysE; TIGR01172 405531000340 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 405531000341 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405531000342 trimer interface [polypeptide binding]; other site 405531000343 active site 405531000344 substrate binding site [chemical binding]; other site 405531000345 CoA binding site [chemical binding]; other site 405531000346 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 405531000347 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405531000348 active site 405531000349 HIGH motif; other site 405531000350 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405531000351 KMSKS motif; other site 405531000352 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405531000353 tRNA binding surface [nucleotide binding]; other site 405531000354 anticodon binding site; other site 405531000355 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 405531000356 active site 405531000357 metal binding site [ion binding]; metal-binding site 405531000358 dimerization interface [polypeptide binding]; other site 405531000359 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 405531000360 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405531000361 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405531000362 YacP-like NYN domain; Region: NYN_YacP; pfam05991 405531000363 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 405531000364 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531000365 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405531000366 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 405531000367 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 405531000368 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 405531000369 putative homodimer interface [polypeptide binding]; other site 405531000370 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 405531000371 heterodimer interface [polypeptide binding]; other site 405531000372 homodimer interface [polypeptide binding]; other site 405531000373 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 405531000374 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 405531000375 23S rRNA interface [nucleotide binding]; other site 405531000376 L7/L12 interface [polypeptide binding]; other site 405531000377 putative thiostrepton binding site; other site 405531000378 L25 interface [polypeptide binding]; other site 405531000379 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 405531000380 mRNA/rRNA interface [nucleotide binding]; other site 405531000381 Ribosomal protein L10 leader 405531000382 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 405531000383 23S rRNA interface [nucleotide binding]; other site 405531000384 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 405531000385 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 405531000386 core dimer interface [polypeptide binding]; other site 405531000387 peripheral dimer interface [polypeptide binding]; other site 405531000388 L10 interface [polypeptide binding]; other site 405531000389 L11 interface [polypeptide binding]; other site 405531000390 putative EF-Tu interaction site [polypeptide binding]; other site 405531000391 putative EF-G interaction site [polypeptide binding]; other site 405531000392 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 405531000393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531000394 S-adenosylmethionine binding site [chemical binding]; other site 405531000395 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 405531000396 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405531000397 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405531000398 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405531000399 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 405531000400 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405531000401 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405531000402 RPB10 interaction site [polypeptide binding]; other site 405531000403 RPB1 interaction site [polypeptide binding]; other site 405531000404 RPB11 interaction site [polypeptide binding]; other site 405531000405 RPB3 interaction site [polypeptide binding]; other site 405531000406 RPB12 interaction site [polypeptide binding]; other site 405531000407 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 405531000408 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 405531000409 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 405531000410 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 405531000411 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 405531000412 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 405531000413 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 405531000414 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 405531000415 G-loop; other site 405531000416 DNA binding site [nucleotide binding] 405531000417 hypothetical protein; Provisional; Region: PRK06683 405531000418 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 405531000419 S17 interaction site [polypeptide binding]; other site 405531000420 S8 interaction site; other site 405531000421 16S rRNA interaction site [nucleotide binding]; other site 405531000422 streptomycin interaction site [chemical binding]; other site 405531000423 23S rRNA interaction site [nucleotide binding]; other site 405531000424 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 405531000425 30S ribosomal protein S7; Validated; Region: PRK05302 405531000426 elongation factor G; Reviewed; Region: PRK00007 405531000427 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 405531000428 G1 box; other site 405531000429 putative GEF interaction site [polypeptide binding]; other site 405531000430 GTP/Mg2+ binding site [chemical binding]; other site 405531000431 Switch I region; other site 405531000432 G2 box; other site 405531000433 G3 box; other site 405531000434 Switch II region; other site 405531000435 G4 box; other site 405531000436 G5 box; other site 405531000437 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405531000438 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 405531000439 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 405531000440 elongation factor Tu; Reviewed; Region: PRK00049 405531000441 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405531000442 G1 box; other site 405531000443 GEF interaction site [polypeptide binding]; other site 405531000444 GTP/Mg2+ binding site [chemical binding]; other site 405531000445 Switch I region; other site 405531000446 G2 box; other site 405531000447 G3 box; other site 405531000448 Switch II region; other site 405531000449 G4 box; other site 405531000450 G5 box; other site 405531000451 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405531000452 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405531000453 Antibiotic Binding Site [chemical binding]; other site 405531000454 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 405531000455 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 405531000456 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 405531000457 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 405531000458 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 405531000459 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 405531000460 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 405531000461 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 405531000462 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 405531000463 putative translocon binding site; other site 405531000464 protein-rRNA interface [nucleotide binding]; other site 405531000465 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 405531000466 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 405531000467 G-X-X-G motif; other site 405531000468 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 405531000469 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 405531000470 23S rRNA interface [nucleotide binding]; other site 405531000471 5S rRNA interface [nucleotide binding]; other site 405531000472 putative antibiotic binding site [chemical binding]; other site 405531000473 L25 interface [polypeptide binding]; other site 405531000474 L27 interface [polypeptide binding]; other site 405531000475 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 405531000476 23S rRNA interface [nucleotide binding]; other site 405531000477 putative translocon interaction site; other site 405531000478 signal recognition particle (SRP54) interaction site; other site 405531000479 L23 interface [polypeptide binding]; other site 405531000480 trigger factor interaction site; other site 405531000481 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 405531000482 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 405531000483 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 405531000484 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 405531000485 RNA binding site [nucleotide binding]; other site 405531000486 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 405531000487 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 405531000488 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 405531000489 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 405531000490 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 405531000491 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 405531000492 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405531000493 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405531000494 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 405531000495 5S rRNA interface [nucleotide binding]; other site 405531000496 L27 interface [polypeptide binding]; other site 405531000497 23S rRNA interface [nucleotide binding]; other site 405531000498 L5 interface [polypeptide binding]; other site 405531000499 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 405531000500 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 405531000501 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 405531000502 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 405531000503 23S rRNA binding site [nucleotide binding]; other site 405531000504 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 405531000505 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405531000506 SecY translocase; Region: SecY; pfam00344 405531000507 adenylate kinase; Reviewed; Region: adk; PRK00279 405531000508 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 405531000509 AMP-binding site [chemical binding]; other site 405531000510 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 405531000511 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405531000512 active site 405531000513 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 405531000514 rRNA binding site [nucleotide binding]; other site 405531000515 predicted 30S ribosome binding site; other site 405531000516 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 405531000517 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 405531000518 30S ribosomal protein S13; Region: bact_S13; TIGR03631 405531000519 30S ribosomal protein S11; Validated; Region: PRK05309 405531000520 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 405531000521 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 405531000522 alphaNTD - beta interaction site [polypeptide binding]; other site 405531000523 alphaNTD homodimer interface [polypeptide binding]; other site 405531000524 alphaNTD - beta' interaction site [polypeptide binding]; other site 405531000525 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 405531000526 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 405531000527 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 405531000528 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405531000529 Walker A/P-loop; other site 405531000530 ATP binding site [chemical binding]; other site 405531000531 Q-loop/lid; other site 405531000532 ABC transporter signature motif; other site 405531000533 Walker B; other site 405531000534 D-loop; other site 405531000535 H-loop/switch region; other site 405531000536 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 405531000537 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405531000538 Walker A/P-loop; other site 405531000539 ATP binding site [chemical binding]; other site 405531000540 Q-loop/lid; other site 405531000541 ABC transporter signature motif; other site 405531000542 Walker B; other site 405531000543 D-loop; other site 405531000544 H-loop/switch region; other site 405531000545 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405531000546 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 405531000547 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405531000548 dimerization interface 3.5A [polypeptide binding]; other site 405531000549 active site 405531000550 Ribosomal protein L13 leader 405531000551 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 405531000552 23S rRNA interface [nucleotide binding]; other site 405531000553 L3 interface [polypeptide binding]; other site 405531000554 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 405531000555 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 405531000556 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405531000557 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405531000558 active site 405531000559 metal binding site [ion binding]; metal-binding site 405531000560 Domain of unknown function DUF59; Region: DUF59; cl00941 405531000561 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405531000562 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 405531000563 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 405531000564 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531000565 Putative catalytic NodB homology domain of Bacillus subtilis putative polysaccharide deacetylase PdaB, and its bacterial homologs; Region: CE4_BsPdaB_like; cd10949 405531000566 NodB motif; other site 405531000567 putative active site [active] 405531000568 putative catalytic site [active] 405531000569 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 405531000570 Arginase family; Region: Arginase; cd09989 405531000571 agmatinase; Region: agmatinase; TIGR01230 405531000572 active site 405531000573 Mn binding site [ion binding]; other site 405531000574 oligomer interface [polypeptide binding]; other site 405531000575 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405531000576 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405531000577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 405531000578 YbbR-like protein; Region: YbbR; pfam07949 405531000579 YbbR-like protein; Region: YbbR; pfam07949 405531000580 YbbR-like protein; Region: YbbR; pfam07949 405531000581 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 405531000582 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 405531000583 active site 405531000584 substrate binding site [chemical binding]; other site 405531000585 metal binding site [ion binding]; metal-binding site 405531000586 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 405531000587 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 405531000588 glutaminase active site [active] 405531000589 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405531000590 dimer interface [polypeptide binding]; other site 405531000591 active site 405531000592 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 405531000593 dimer interface [polypeptide binding]; other site 405531000594 active site 405531000595 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 405531000596 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531000597 Protein of unknown function (DUF4256); Region: DUF4256; pfam14066 405531000598 DoxX; Region: DoxX; cl17842 405531000599 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12859 405531000600 classical (c) SDRs; Region: SDR_c; cd05233 405531000601 NAD(P) binding site [chemical binding]; other site 405531000602 active site 405531000603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531000604 ABC-ATPase subunit interface; other site 405531000605 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405531000606 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405531000607 Walker A/P-loop; other site 405531000608 ATP binding site [chemical binding]; other site 405531000609 Q-loop/lid; other site 405531000610 ABC transporter signature motif; other site 405531000611 Walker B; other site 405531000612 D-loop; other site 405531000613 H-loop/switch region; other site 405531000614 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405531000615 NIL domain; Region: NIL; pfam09383 405531000616 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405531000617 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405531000618 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405531000619 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 405531000620 putative NAD(P) binding site [chemical binding]; other site 405531000621 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405531000622 FAD binding domain; Region: FAD_binding_4; pfam01565 405531000623 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 405531000624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531000626 putative substrate translocation pore; other site 405531000627 Domain of unknown function (DUF3981); Region: DUF3981; pfam13139 405531000628 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405531000629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531000630 putative substrate translocation pore; other site 405531000631 Protein of unknown function (DUF3887); Region: DUF3887; pfam13026 405531000632 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405531000633 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405531000634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531000635 dimer interface [polypeptide binding]; other site 405531000636 conserved gate region; other site 405531000637 putative PBP binding loops; other site 405531000638 ABC-ATPase subunit interface; other site 405531000639 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405531000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531000641 dimer interface [polypeptide binding]; other site 405531000642 conserved gate region; other site 405531000643 putative PBP binding loops; other site 405531000644 ABC-ATPase subunit interface; other site 405531000645 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405531000646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531000647 Walker A/P-loop; other site 405531000648 ATP binding site [chemical binding]; other site 405531000649 Q-loop/lid; other site 405531000650 ABC transporter signature motif; other site 405531000651 Walker B; other site 405531000652 D-loop; other site 405531000653 H-loop/switch region; other site 405531000654 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405531000655 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405531000656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531000657 Walker A/P-loop; other site 405531000658 ATP binding site [chemical binding]; other site 405531000659 Q-loop/lid; other site 405531000660 ABC transporter signature motif; other site 405531000661 Walker B; other site 405531000662 D-loop; other site 405531000663 H-loop/switch region; other site 405531000664 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405531000665 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531000666 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531000667 peptide binding site [polypeptide binding]; other site 405531000668 YusW-like protein; Region: YusW; pfam14039 405531000669 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531000670 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531000671 peptide binding site [polypeptide binding]; other site 405531000672 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531000673 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531000674 peptide binding site [polypeptide binding]; other site 405531000675 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531000676 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531000677 active site 405531000678 catalytic tetrad [active] 405531000679 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 405531000680 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405531000681 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405531000682 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405531000683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531000684 dimer interface [polypeptide binding]; other site 405531000685 conserved gate region; other site 405531000686 putative PBP binding loops; other site 405531000687 ABC-ATPase subunit interface; other site 405531000688 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 405531000689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405531000690 dimerization interface [polypeptide binding]; other site 405531000691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531000692 membrane-bound complex binding site; other site 405531000693 hinge residues; other site 405531000694 DNA binding domain, excisionase family; Region: excise; TIGR01764 405531000695 PBP superfamily domain; Region: PBP_like; pfam12727 405531000696 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531000697 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531000698 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405531000699 putative dimerization interface [polypeptide binding]; other site 405531000700 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531000701 EamA-like transporter family; Region: EamA; pfam00892 405531000702 YrzO-like protein; Region: YrzO; pfam14142 405531000703 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405531000704 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405531000705 putative acyl-acceptor binding pocket; other site 405531000706 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531000707 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531000708 DNA binding site [nucleotide binding] 405531000709 domain linker motif; other site 405531000710 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405531000711 putative ligand binding site [chemical binding]; other site 405531000712 putative dimerization interface [polypeptide binding]; other site 405531000713 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531000714 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531000715 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531000716 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531000717 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531000718 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405531000719 active site 405531000720 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 405531000721 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 405531000722 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405531000723 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405531000724 catalytic residue [active] 405531000725 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 405531000726 nucleotide binding site/active site [active] 405531000727 HIT family signature motif; other site 405531000728 catalytic residue [active] 405531000729 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531000730 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531000731 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531000732 ABC transporter; Region: ABC_tran_2; pfam12848 405531000733 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531000734 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405531000735 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405531000736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405531000737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531000738 dimer interface [polypeptide binding]; other site 405531000739 conserved gate region; other site 405531000740 putative PBP binding loops; other site 405531000741 ABC-ATPase subunit interface; other site 405531000742 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405531000743 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405531000744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531000745 dimer interface [polypeptide binding]; other site 405531000746 conserved gate region; other site 405531000747 putative PBP binding loops; other site 405531000748 ABC-ATPase subunit interface; other site 405531000749 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405531000750 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531000751 Walker A/P-loop; other site 405531000752 ATP binding site [chemical binding]; other site 405531000753 Q-loop/lid; other site 405531000754 ABC transporter signature motif; other site 405531000755 Walker B; other site 405531000756 D-loop; other site 405531000757 H-loop/switch region; other site 405531000758 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405531000759 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405531000760 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531000761 Walker A/P-loop; other site 405531000762 ATP binding site [chemical binding]; other site 405531000763 Q-loop/lid; other site 405531000764 ABC transporter signature motif; other site 405531000765 Walker B; other site 405531000766 D-loop; other site 405531000767 H-loop/switch region; other site 405531000768 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405531000769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531000770 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531000771 active site 405531000772 motif I; other site 405531000773 motif II; other site 405531000774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531000775 motif II; other site 405531000776 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405531000777 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405531000778 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405531000779 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405531000780 Protein of unknown function (DUF3948); Region: DUF3948; pfam13134 405531000781 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 405531000782 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 405531000783 dimer interface [polypeptide binding]; other site 405531000784 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 405531000785 active site 405531000786 Fe binding site [ion binding]; other site 405531000787 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405531000788 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405531000789 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 405531000790 amino acid transporter; Region: 2A0306; TIGR00909 405531000791 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405531000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531000793 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531000794 putative substrate translocation pore; other site 405531000795 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 405531000796 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405531000797 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 405531000798 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 405531000799 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405531000800 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405531000801 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405531000802 helicase 45; Provisional; Region: PTZ00424 405531000803 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405531000804 ATP binding site [chemical binding]; other site 405531000805 Mg++ binding site [ion binding]; other site 405531000806 motif III; other site 405531000807 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531000808 nucleotide binding region [chemical binding]; other site 405531000809 ATP-binding site [chemical binding]; other site 405531000810 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405531000811 Rhomboid family; Region: Rhomboid; pfam01694 405531000812 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 405531000813 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 405531000814 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405531000815 alanine racemase; Reviewed; Region: alr; PRK00053 405531000816 active site 405531000817 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405531000818 dimer interface [polypeptide binding]; other site 405531000819 substrate binding site [chemical binding]; other site 405531000820 catalytic residues [active] 405531000821 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 405531000822 PemK-like protein; Region: PemK; pfam02452 405531000823 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 405531000824 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 405531000825 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 405531000826 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 405531000827 RNA binding site [nucleotide binding]; other site 405531000828 hypothetical protein; Provisional; Region: PRK04351 405531000829 SprT homologues; Region: SprT; cl01182 405531000830 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 405531000831 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405531000832 Glycoprotease family; Region: Peptidase_M22; pfam00814 405531000833 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405531000834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531000835 Coenzyme A binding pocket [chemical binding]; other site 405531000836 UGMP family protein; Validated; Region: PRK09604 405531000837 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 405531000838 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405531000839 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531000840 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531000841 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531000842 ABC transporter; Region: ABC_tran_2; pfam12848 405531000843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531000844 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 405531000845 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 405531000846 CoA binding domain; Region: CoA_binding; pfam02629 405531000847 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 405531000848 CAAX protease self-immunity; Region: Abi; pfam02517 405531000849 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 405531000850 oligomerisation interface [polypeptide binding]; other site 405531000851 mobile loop; other site 405531000852 roof hairpin; other site 405531000853 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405531000854 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405531000855 ring oligomerisation interface [polypeptide binding]; other site 405531000856 ATP/Mg binding site [chemical binding]; other site 405531000857 stacking interactions; other site 405531000858 hinge regions; other site 405531000859 GMP synthase; Reviewed; Region: guaA; PRK00074 405531000860 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 405531000861 AMP/PPi binding site [chemical binding]; other site 405531000862 candidate oxyanion hole; other site 405531000863 catalytic triad [active] 405531000864 potential glutamine specificity residues [chemical binding]; other site 405531000865 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 405531000866 ATP Binding subdomain [chemical binding]; other site 405531000867 Ligand Binding sites [chemical binding]; other site 405531000868 Dimerization subdomain; other site 405531000869 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405531000870 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531000871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531000872 active site 405531000873 phosphorylation site [posttranslational modification] 405531000874 intermolecular recognition site; other site 405531000875 dimerization interface [polypeptide binding]; other site 405531000876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531000877 DNA binding site [nucleotide binding] 405531000878 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531000879 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531000880 dimerization interface [polypeptide binding]; other site 405531000881 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531000882 dimer interface [polypeptide binding]; other site 405531000883 phosphorylation site [posttranslational modification] 405531000884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531000885 ATP binding site [chemical binding]; other site 405531000886 Mg2+ binding site [ion binding]; other site 405531000887 G-X-G motif; other site 405531000888 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531000889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531000890 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531000891 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405531000892 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405531000893 catalytic residues [active] 405531000894 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405531000895 Proline dehydrogenase; Region: Pro_dh; cl03282 405531000896 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 405531000897 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405531000898 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405531000899 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531000900 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405531000901 Walker A/P-loop; other site 405531000902 ATP binding site [chemical binding]; other site 405531000903 Q-loop/lid; other site 405531000904 ABC transporter signature motif; other site 405531000905 Walker B; other site 405531000906 D-loop; other site 405531000907 H-loop/switch region; other site 405531000908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531000909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531000910 dimer interface [polypeptide binding]; other site 405531000911 phosphorylation site [posttranslational modification] 405531000912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531000913 ATP binding site [chemical binding]; other site 405531000914 Mg2+ binding site [ion binding]; other site 405531000915 G-X-G motif; other site 405531000916 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531000917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531000918 active site 405531000919 phosphorylation site [posttranslational modification] 405531000920 intermolecular recognition site; other site 405531000921 dimerization interface [polypeptide binding]; other site 405531000922 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531000923 DNA binding site [nucleotide binding] 405531000924 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531000925 EamA-like transporter family; Region: EamA; pfam00892 405531000926 EamA-like transporter family; Region: EamA; pfam00892 405531000927 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 405531000928 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 405531000929 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 405531000930 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 405531000931 NAD binding site [chemical binding]; other site 405531000932 ATP-grasp domain; Region: ATP-grasp; pfam02222 405531000933 adenylosuccinate lyase; Provisional; Region: PRK07492 405531000934 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 405531000935 tetramer interface [polypeptide binding]; other site 405531000936 active site 405531000937 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 405531000938 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 405531000939 ATP binding site [chemical binding]; other site 405531000940 active site 405531000941 substrate binding site [chemical binding]; other site 405531000942 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 405531000943 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 405531000944 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 405531000945 putative active site [active] 405531000946 catalytic triad [active] 405531000947 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 405531000948 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 405531000949 dimerization interface [polypeptide binding]; other site 405531000950 ATP binding site [chemical binding]; other site 405531000951 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 405531000952 dimerization interface [polypeptide binding]; other site 405531000953 ATP binding site [chemical binding]; other site 405531000954 amidophosphoribosyltransferase; Provisional; Region: PRK06781 405531000955 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 405531000956 active site 405531000957 tetramer interface [polypeptide binding]; other site 405531000958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531000959 active site 405531000960 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 405531000961 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 405531000962 dimerization interface [polypeptide binding]; other site 405531000963 putative ATP binding site [chemical binding]; other site 405531000964 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 405531000965 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 405531000966 active site 405531000967 substrate binding site [chemical binding]; other site 405531000968 cosubstrate binding site; other site 405531000969 catalytic site [active] 405531000970 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 405531000971 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 405531000972 purine monophosphate binding site [chemical binding]; other site 405531000973 dimer interface [polypeptide binding]; other site 405531000974 putative catalytic residues [active] 405531000975 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 405531000976 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 405531000977 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 405531000978 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 405531000979 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 405531000980 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405531000981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 405531000982 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 405531000983 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405531000984 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 405531000985 PcrB family; Region: PcrB; pfam01884 405531000986 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 405531000987 substrate binding site [chemical binding]; other site 405531000988 putative active site [active] 405531000989 dimer interface [polypeptide binding]; other site 405531000990 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 405531000991 Part of AAA domain; Region: AAA_19; pfam13245 405531000992 Family description; Region: UvrD_C_2; pfam13538 405531000993 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 405531000994 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 405531000995 nucleotide binding pocket [chemical binding]; other site 405531000996 K-X-D-G motif; other site 405531000997 catalytic site [active] 405531000998 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405531000999 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 405531001000 Dimer interface [polypeptide binding]; other site 405531001001 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405531001002 putative dimer interface [polypeptide binding]; other site 405531001003 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405531001004 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405531001005 putative dimer interface [polypeptide binding]; other site 405531001006 hypothetical protein; Provisional; Region: PRK10621 405531001007 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531001008 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 405531001009 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 405531001010 Glutamate binding site [chemical binding]; other site 405531001011 homodimer interface [polypeptide binding]; other site 405531001012 NAD binding site [chemical binding]; other site 405531001013 catalytic residues [active] 405531001014 Isochorismatase family; Region: Isochorismatase; pfam00857 405531001015 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405531001016 catalytic triad [active] 405531001017 conserved cis-peptide bond; other site 405531001018 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405531001019 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405531001020 Walker A/P-loop; other site 405531001021 ATP binding site [chemical binding]; other site 405531001022 Q-loop/lid; other site 405531001023 ABC transporter signature motif; other site 405531001024 Walker B; other site 405531001025 D-loop; other site 405531001026 H-loop/switch region; other site 405531001027 NIL domain; Region: NIL; pfam09383 405531001028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001029 dimer interface [polypeptide binding]; other site 405531001030 conserved gate region; other site 405531001031 ABC-ATPase subunit interface; other site 405531001032 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405531001033 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405531001034 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 405531001035 Protein of unknown function (DUF3926); Region: DUF3926; pfam13080 405531001036 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 405531001037 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 405531001038 P loop; other site 405531001039 Nucleotide binding site [chemical binding]; other site 405531001040 DTAP/Switch II; other site 405531001041 Switch I; other site 405531001042 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405531001043 putative dimer interface [polypeptide binding]; other site 405531001044 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531001045 MarR family; Region: MarR; pfam01047 405531001046 MarR family; Region: MarR_2; cl17246 405531001047 yiaA/B two helix domain; Region: YiaAB; pfam05360 405531001048 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 405531001049 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 405531001050 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 405531001051 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 405531001052 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 405531001053 GatB domain; Region: GatB_Yqey; pfam02637 405531001054 putative lipid kinase; Reviewed; Region: PRK13337 405531001055 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405531001056 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405531001057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531001058 motif II; other site 405531001059 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 405531001060 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531001061 inhibitor-cofactor binding pocket; inhibition site 405531001062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531001063 catalytic residue [active] 405531001064 PAS domain; Region: PAS_9; pfam13426 405531001065 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531001066 putative active site [active] 405531001067 heme pocket [chemical binding]; other site 405531001068 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405531001069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531001070 Walker A motif; other site 405531001071 ATP binding site [chemical binding]; other site 405531001072 Walker B motif; other site 405531001073 arginine finger; other site 405531001074 succinic semialdehyde dehydrogenase; Region: PLN02278 405531001075 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 405531001076 tetramerization interface [polypeptide binding]; other site 405531001077 NAD(P) binding site [chemical binding]; other site 405531001078 catalytic residues [active] 405531001079 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531001080 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405531001081 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405531001082 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405531001083 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531001084 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 405531001085 putative active site [active] 405531001086 putative metal binding site [ion binding]; other site 405531001087 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405531001088 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405531001089 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405531001090 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 405531001091 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405531001092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531001093 S-adenosylmethionine binding site [chemical binding]; other site 405531001094 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 405531001095 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405531001096 FMN binding site [chemical binding]; other site 405531001097 active site 405531001098 catalytic residues [active] 405531001099 substrate binding site [chemical binding]; other site 405531001100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 405531001101 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405531001102 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405531001103 potential frameshift: common BLAST hit: gi|52144912|ref|YP_081918.1| zinc metalloprotease 405531001104 Protein of unknown function DUF45; Region: DUF45; pfam01863 405531001105 Protein of unknown function DUF45; Region: DUF45; cl00636 405531001106 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 405531001107 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405531001108 active site 405531001109 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405531001110 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 405531001111 amidohydrolase; Region: amidohydrolases; TIGR01891 405531001112 metal binding site [ion binding]; metal-binding site 405531001113 putative dimer interface [polypeptide binding]; other site 405531001114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531001115 S-adenosylmethionine binding site [chemical binding]; other site 405531001116 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 405531001117 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 405531001118 catalytic residue [active] 405531001119 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 405531001120 catalytic residues [active] 405531001121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531001122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531001123 peroxiredoxin; Region: AhpC; TIGR03137 405531001124 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 405531001125 dimer interface [polypeptide binding]; other site 405531001126 decamer (pentamer of dimers) interface [polypeptide binding]; other site 405531001127 catalytic triad [active] 405531001128 peroxidatic and resolving cysteines [active] 405531001129 5-methylribose kinase; Reviewed; Region: PRK12396 405531001130 Phosphotransferase enzyme family; Region: APH; pfam01636 405531001131 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405531001132 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405531001133 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 405531001134 intersubunit interface [polypeptide binding]; other site 405531001135 active site 405531001136 Zn2+ binding site [ion binding]; other site 405531001137 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531001138 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531001139 ABC-ATPase subunit interface; other site 405531001140 dimer interface [polypeptide binding]; other site 405531001141 putative PBP binding regions; other site 405531001142 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531001143 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531001144 ABC-ATPase subunit interface; other site 405531001145 dimer interface [polypeptide binding]; other site 405531001146 putative PBP binding regions; other site 405531001147 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405531001148 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405531001149 putative ligand binding residues [chemical binding]; other site 405531001150 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405531001151 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531001152 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 405531001153 DNA binding domain, excisionase family; Region: excise; TIGR01764 405531001154 Sm and related proteins; Region: Sm_like; cl00259 405531001155 Sm1 motif; other site 405531001156 RNA binding site [nucleotide binding]; other site 405531001157 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405531001158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531001159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531001160 dimer interface [polypeptide binding]; other site 405531001161 phosphorylation site [posttranslational modification] 405531001162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531001163 ATP binding site [chemical binding]; other site 405531001164 Mg2+ binding site [ion binding]; other site 405531001165 G-X-G motif; other site 405531001166 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 405531001167 hypothetical protein; Provisional; Region: PRK06851 405531001168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531001169 Walker A motif; other site 405531001170 ATP binding site [chemical binding]; other site 405531001171 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 405531001172 benzoate transport; Region: 2A0115; TIGR00895 405531001173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531001174 putative substrate translocation pore; other site 405531001175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531001176 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405531001177 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405531001178 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405531001179 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 405531001180 [2Fe-2S] cluster binding site [ion binding]; other site 405531001181 Fatty acid desaturase; Region: FA_desaturase; pfam00487 405531001182 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 405531001183 putative di-iron ligands [ion binding]; other site 405531001184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001185 dimer interface [polypeptide binding]; other site 405531001186 conserved gate region; other site 405531001187 putative PBP binding loops; other site 405531001188 ABC-ATPase subunit interface; other site 405531001189 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405531001190 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531001191 substrate binding pocket [chemical binding]; other site 405531001192 membrane-bound complex binding site; other site 405531001193 hinge residues; other site 405531001194 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405531001195 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405531001196 Walker A/P-loop; other site 405531001197 ATP binding site [chemical binding]; other site 405531001198 Q-loop/lid; other site 405531001199 ABC transporter signature motif; other site 405531001200 Walker B; other site 405531001201 D-loop; other site 405531001202 H-loop/switch region; other site 405531001203 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405531001204 HAMP domain; Region: HAMP; pfam00672 405531001205 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531001206 dimer interface [polypeptide binding]; other site 405531001207 putative CheW interface [polypeptide binding]; other site 405531001208 Arginine repressor [Transcription]; Region: ArgR; COG1438 405531001209 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405531001210 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405531001211 arginine deiminase; Provisional; Region: PRK01388 405531001212 ornithine carbamoyltransferase; Validated; Region: PRK02102 405531001213 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405531001214 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405531001215 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405531001216 carbamate kinase; Reviewed; Region: PRK12686 405531001217 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405531001218 putative substrate binding site [chemical binding]; other site 405531001219 nucleotide binding site [chemical binding]; other site 405531001220 nucleotide binding site [chemical binding]; other site 405531001221 homodimer interface [polypeptide binding]; other site 405531001222 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405531001223 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405531001224 ligand binding site [chemical binding]; other site 405531001225 flexible hinge region; other site 405531001226 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405531001227 putative switch regulator; other site 405531001228 non-specific DNA interactions [nucleotide binding]; other site 405531001229 DNA binding site [nucleotide binding] 405531001230 sequence specific DNA binding site [nucleotide binding]; other site 405531001231 putative cAMP binding site [chemical binding]; other site 405531001232 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 405531001233 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405531001234 FAD binding domain; Region: FAD_binding_4; pfam01565 405531001235 Berberine and berberine like; Region: BBE; pfam08031 405531001236 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405531001237 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405531001238 Ca binding site [ion binding]; other site 405531001239 active site 405531001240 catalytic site [active] 405531001241 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405531001242 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 405531001243 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405531001244 active site turn [active] 405531001245 phosphorylation site [posttranslational modification] 405531001246 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 405531001247 putative catalytic site [active] 405531001248 putative metal binding site [ion binding]; other site 405531001249 putative phosphate binding site [ion binding]; other site 405531001250 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405531001251 Predicted membrane protein [Function unknown]; Region: COG1511 405531001252 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405531001253 DNA topoisomerase III; Provisional; Region: PRK07726 405531001254 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405531001255 active site 405531001256 putative interdomain interaction site [polypeptide binding]; other site 405531001257 putative metal-binding site [ion binding]; other site 405531001258 putative nucleotide binding site [chemical binding]; other site 405531001259 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405531001260 domain I; other site 405531001261 DNA binding groove [nucleotide binding] 405531001262 phosphate binding site [ion binding]; other site 405531001263 domain II; other site 405531001264 domain III; other site 405531001265 nucleotide binding site [chemical binding]; other site 405531001266 catalytic site [active] 405531001267 domain IV; other site 405531001268 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 405531001269 substrate binding site [chemical binding]; other site 405531001270 multimerization interface [polypeptide binding]; other site 405531001271 ATP binding site [chemical binding]; other site 405531001272 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405531001273 thiamine phosphate binding site [chemical binding]; other site 405531001274 active site 405531001275 pyrophosphate binding site [ion binding]; other site 405531001276 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 405531001277 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 405531001278 HAMP domain; Region: HAMP; pfam00672 405531001279 dimerization interface [polypeptide binding]; other site 405531001280 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531001281 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531001282 dimer interface [polypeptide binding]; other site 405531001283 putative CheW interface [polypeptide binding]; other site 405531001284 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531001285 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405531001286 acyl-activating enzyme (AAE) consensus motif; other site 405531001287 AMP binding site [chemical binding]; other site 405531001288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531001289 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 405531001290 putative NAD(P) binding site [chemical binding]; other site 405531001291 active site 405531001292 putative substrate binding site [chemical binding]; other site 405531001293 Domain of unknown function DUF77; Region: DUF77; pfam01910 405531001294 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405531001295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001296 dimer interface [polypeptide binding]; other site 405531001297 conserved gate region; other site 405531001298 putative PBP binding loops; other site 405531001299 ABC-ATPase subunit interface; other site 405531001300 NMT1/THI5 like; Region: NMT1; pfam09084 405531001301 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 405531001302 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405531001303 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405531001304 Walker A/P-loop; other site 405531001305 ATP binding site [chemical binding]; other site 405531001306 Q-loop/lid; other site 405531001307 ABC transporter signature motif; other site 405531001308 Walker B; other site 405531001309 D-loop; other site 405531001310 H-loop/switch region; other site 405531001311 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531001312 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531001313 Walker A/P-loop; other site 405531001314 ATP binding site [chemical binding]; other site 405531001315 Q-loop/lid; other site 405531001316 ABC transporter signature motif; other site 405531001317 Walker B; other site 405531001318 D-loop; other site 405531001319 H-loop/switch region; other site 405531001320 ABC transporter; Region: ABC_tran_2; pfam12848 405531001321 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531001322 Glyco_18 domain; Region: Glyco_18; smart00636 405531001323 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 405531001324 active site 405531001325 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531001326 Interdomain contacts; other site 405531001327 Cytokine receptor motif; other site 405531001328 Cellulose binding domain; Region: CBM_2; pfam00553 405531001329 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405531001330 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531001331 catalytic residues [active] 405531001332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531001333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531001334 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 405531001335 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531001336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531001337 putative substrate translocation pore; other site 405531001338 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531001339 non-specific DNA binding site [nucleotide binding]; other site 405531001340 salt bridge; other site 405531001341 sequence-specific DNA binding site [nucleotide binding]; other site 405531001342 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 405531001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531001344 putative substrate translocation pore; other site 405531001345 Uncharacterized conserved protein [Function unknown]; Region: COG3379 405531001346 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 405531001347 YesK-like protein; Region: YesK; pfam14150 405531001348 prolyl-tRNA synthetase; Provisional; Region: PRK08661 405531001349 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 405531001350 dimer interface [polypeptide binding]; other site 405531001351 motif 1; other site 405531001352 active site 405531001353 motif 2; other site 405531001354 motif 3; other site 405531001355 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 405531001356 anticodon binding site; other site 405531001357 zinc-binding site [ion binding]; other site 405531001358 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405531001359 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405531001360 nucleotide binding site [chemical binding]; other site 405531001361 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405531001362 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405531001363 putative metal binding site [ion binding]; other site 405531001364 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405531001365 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405531001366 putative metal binding site [ion binding]; other site 405531001367 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405531001368 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405531001369 putative metal binding site [ion binding]; other site 405531001370 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405531001371 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 405531001372 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405531001373 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405531001374 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405531001375 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531001376 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405531001377 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405531001378 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405531001379 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 405531001380 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405531001381 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405531001382 active site 405531001383 Domain of unknown function (DUF4075); Region: DUF4075; pfam13294 405531001384 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 405531001385 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 405531001386 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531001387 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405531001388 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531001389 EamA-like transporter family; Region: EamA; pfam00892 405531001390 EamA-like transporter family; Region: EamA; pfam00892 405531001391 YhhN-like protein; Region: YhhN; pfam07947 405531001392 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531001393 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531001394 Catalytic site [active] 405531001395 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531001396 binding surface 405531001397 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405531001398 TPR motif; other site 405531001399 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531001400 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531001401 Predicted membrane protein [Function unknown]; Region: COG2510 405531001402 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 405531001403 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 405531001404 calcium/proton exchanger (cax); Region: cax; TIGR00378 405531001405 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405531001406 YfkD-like protein; Region: YfkD; pfam14167 405531001407 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405531001408 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531001409 FeS/SAM binding site; other site 405531001410 YfkB-like domain; Region: YfkB; pfam08756 405531001411 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 405531001412 Fumarase C-terminus; Region: Fumerase_C; pfam05683 405531001413 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 405531001414 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405531001415 NodB motif; other site 405531001416 active site 405531001417 catalytic site [active] 405531001418 Cd binding site [ion binding]; other site 405531001419 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405531001420 endonuclease III; Region: ENDO3c; smart00478 405531001421 minor groove reading motif; other site 405531001422 helix-hairpin-helix signature motif; other site 405531001423 substrate binding pocket [chemical binding]; other site 405531001424 active site 405531001425 TRAM domain; Region: TRAM; pfam01938 405531001426 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 405531001427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531001428 S-adenosylmethionine binding site [chemical binding]; other site 405531001429 tRNA pseudouridine synthase A; Reviewed; Region: PRK12434 405531001430 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405531001431 dimerization interface 3.5A [polypeptide binding]; other site 405531001432 active site 405531001433 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405531001434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531001435 Walker A motif; other site 405531001436 ATP binding site [chemical binding]; other site 405531001437 Walker B motif; other site 405531001438 arginine finger; other site 405531001439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405531001440 hypothetical protein; Validated; Region: PRK06748 405531001441 S-methylmethionine transporter; Provisional; Region: PRK11387 405531001442 acetylornithine deacetylase; Validated; Region: PRK08596 405531001443 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405531001444 metal binding site [ion binding]; metal-binding site 405531001445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531001446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531001447 non-specific DNA binding site [nucleotide binding]; other site 405531001448 salt bridge; other site 405531001449 sequence-specific DNA binding site [nucleotide binding]; other site 405531001450 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 405531001451 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405531001452 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 405531001453 glutaminase A; Region: Gln_ase; TIGR03814 405531001454 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405531001455 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 405531001456 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405531001457 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405531001458 active site turn [active] 405531001459 phosphorylation site [posttranslational modification] 405531001460 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531001461 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531001462 Sm and related proteins; Region: Sm_like; cl00259 405531001463 heptamer interface [polypeptide binding]; other site 405531001464 Sm1 motif; other site 405531001465 hexamer interface [polypeptide binding]; other site 405531001466 RNA binding site [nucleotide binding]; other site 405531001467 Sm2 motif; other site 405531001468 Sm and related proteins; Region: Sm_like; cl00259 405531001469 Sm1 motif; other site 405531001470 RNA binding site [nucleotide binding]; other site 405531001471 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405531001472 active site 405531001473 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531001474 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405531001475 active site 405531001476 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 405531001477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531001478 NAD(P) binding site [chemical binding]; other site 405531001479 active site 405531001480 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405531001481 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405531001482 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531001483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531001484 NAD(P) binding site [chemical binding]; other site 405531001485 active site 405531001486 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531001487 active site 405531001488 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531001489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531001490 active site 405531001491 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 405531001492 Pyruvate formate lyase 1; Region: PFL1; cd01678 405531001493 coenzyme A binding site [chemical binding]; other site 405531001494 active site 405531001495 catalytic residues [active] 405531001496 glycine loop; other site 405531001497 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 405531001498 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531001499 FeS/SAM binding site; other site 405531001500 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 405531001501 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 405531001502 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405531001503 YfhE-like protein; Region: YfhE; pfam14152 405531001504 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531001505 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 405531001506 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 405531001507 active site 405531001508 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 405531001509 TIGR01777 family protein; Region: yfcH 405531001510 putative NAD(P) binding site [chemical binding]; other site 405531001511 putative active site [active] 405531001512 recombination regulator RecX; Provisional; Region: recX; PRK14135 405531001513 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 405531001514 Small acid-soluble spore protein K family; Region: SspK; pfam08176 405531001515 WVELL protein; Region: WVELL; pfam14043 405531001516 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 405531001517 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 405531001518 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405531001519 minor groove reading motif; other site 405531001520 helix-hairpin-helix signature motif; other site 405531001521 substrate binding pocket [chemical binding]; other site 405531001522 active site 405531001523 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405531001524 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 405531001525 DNA binding and oxoG recognition site [nucleotide binding] 405531001526 YgaB-like protein; Region: YgaB; pfam14182 405531001527 hypothetical protein; Provisional; Region: PRK13662 405531001528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531001529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531001530 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405531001531 Walker A/P-loop; other site 405531001532 ATP binding site [chemical binding]; other site 405531001533 Q-loop/lid; other site 405531001534 ABC transporter signature motif; other site 405531001535 Walker B; other site 405531001536 D-loop; other site 405531001537 H-loop/switch region; other site 405531001538 Predicted membrane protein [Function unknown]; Region: COG4129 405531001539 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405531001540 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 405531001541 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 405531001542 active site 405531001543 dimer interface [polypeptide binding]; other site 405531001544 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 405531001545 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405531001546 active site 405531001547 FMN binding site [chemical binding]; other site 405531001548 substrate binding site [chemical binding]; other site 405531001549 3Fe-4S cluster binding site [ion binding]; other site 405531001550 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 405531001551 domain_subunit interface; other site 405531001552 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 405531001553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531001554 inhibitor-cofactor binding pocket; inhibition site 405531001555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531001556 catalytic residue [active] 405531001557 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 405531001558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531001559 Walker A/P-loop; other site 405531001560 ATP binding site [chemical binding]; other site 405531001561 Q-loop/lid; other site 405531001562 ABC transporter signature motif; other site 405531001563 Walker B; other site 405531001564 D-loop; other site 405531001565 H-loop/switch region; other site 405531001566 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405531001567 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405531001568 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405531001569 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405531001570 Ion channel; Region: Ion_trans_2; pfam07885 405531001571 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 405531001572 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 405531001573 catalytic triad [active] 405531001574 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405531001575 metal binding site 2 [ion binding]; metal-binding site 405531001576 putative DNA binding helix; other site 405531001577 metal binding site 1 [ion binding]; metal-binding site 405531001578 dimer interface [polypeptide binding]; other site 405531001579 structural Zn2+ binding site [ion binding]; other site 405531001580 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531001581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531001582 Coenzyme A binding pocket [chemical binding]; other site 405531001583 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 405531001584 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 405531001585 hypothetical protein; Provisional; Region: PRK12378 405531001586 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405531001587 nudix motif; other site 405531001588 Transglycosylase; Region: Transgly; pfam00912 405531001589 Thioredoxin; Region: Thioredoxin_4; pfam13462 405531001590 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 405531001591 epoxyqueuosine reductase; Region: TIGR00276 405531001592 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 405531001593 4Fe-4S binding domain; Region: Fer4; cl02805 405531001594 Putative amidase domain; Region: Amidase_6; pfam12671 405531001595 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 405531001596 PAS fold; Region: PAS_4; pfam08448 405531001597 PAS domain; Region: PAS_9; pfam13426 405531001598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531001599 putative active site [active] 405531001600 heme pocket [chemical binding]; other site 405531001601 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531001602 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531001603 metal binding site [ion binding]; metal-binding site 405531001604 active site 405531001605 I-site; other site 405531001606 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531001607 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 405531001608 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 405531001609 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 405531001610 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531001611 heme-binding site [chemical binding]; other site 405531001612 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001613 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001614 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001615 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001617 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001618 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531001619 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405531001620 BCCT family transporter; Region: BCCT; pfam02028 405531001621 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405531001622 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405531001623 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405531001624 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405531001625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 405531001626 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 405531001627 Tar ligand binding domain homologue; Region: TarH; pfam02203 405531001628 Cache domain; Region: Cache_1; pfam02743 405531001629 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531001630 dimerization interface [polypeptide binding]; other site 405531001631 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531001632 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531001633 dimer interface [polypeptide binding]; other site 405531001634 putative CheW interface [polypeptide binding]; other site 405531001635 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405531001636 PAS domain; Region: PAS; smart00091 405531001637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531001638 ATP binding site [chemical binding]; other site 405531001639 Mg2+ binding site [ion binding]; other site 405531001640 G-X-G motif; other site 405531001641 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405531001642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531001643 active site 405531001644 phosphorylation site [posttranslational modification] 405531001645 intermolecular recognition site; other site 405531001646 dimerization interface [polypeptide binding]; other site 405531001647 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 405531001648 Citrate transporter; Region: CitMHS; pfam03600 405531001649 hypothetical protein; Provisional; Region: PRK12784 405531001650 NosL; Region: NosL; cl01769 405531001651 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405531001652 Ankyrin repeat; Region: Ank; pfam00023 405531001653 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405531001654 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405531001655 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531001656 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 405531001657 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405531001658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531001659 Walker A/P-loop; other site 405531001660 ATP binding site [chemical binding]; other site 405531001661 Q-loop/lid; other site 405531001662 ABC transporter signature motif; other site 405531001663 Walker B; other site 405531001664 D-loop; other site 405531001665 H-loop/switch region; other site 405531001666 TOBE domain; Region: TOBE_2; pfam08402 405531001667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 405531001668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001669 dimer interface [polypeptide binding]; other site 405531001670 conserved gate region; other site 405531001671 putative PBP binding loops; other site 405531001672 ABC-ATPase subunit interface; other site 405531001673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405531001674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405531001675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001676 dimer interface [polypeptide binding]; other site 405531001677 conserved gate region; other site 405531001678 putative PBP binding loops; other site 405531001679 ABC-ATPase subunit interface; other site 405531001680 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405531001681 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405531001682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531001683 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405531001684 active site 405531001685 metal binding site [ion binding]; metal-binding site 405531001686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531001687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531001688 active site 405531001689 phosphorylation site [posttranslational modification] 405531001690 intermolecular recognition site; other site 405531001691 dimerization interface [polypeptide binding]; other site 405531001692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531001693 DNA binding site [nucleotide binding] 405531001694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531001695 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531001696 dimer interface [polypeptide binding]; other site 405531001697 phosphorylation site [posttranslational modification] 405531001698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531001699 ATP binding site [chemical binding]; other site 405531001700 Mg2+ binding site [ion binding]; other site 405531001701 G-X-G motif; other site 405531001702 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 405531001703 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405531001704 putative active site [active] 405531001705 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405531001706 Cache domain; Region: Cache_1; pfam02743 405531001707 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531001708 dimerization interface [polypeptide binding]; other site 405531001709 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531001710 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531001711 dimer interface [polypeptide binding]; other site 405531001712 putative CheW interface [polypeptide binding]; other site 405531001713 sensory histidine kinase DcuS; Provisional; Region: PRK11086 405531001714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531001715 ATP binding site [chemical binding]; other site 405531001716 Mg2+ binding site [ion binding]; other site 405531001717 G-X-G motif; other site 405531001718 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405531001719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531001720 active site 405531001721 phosphorylation site [posttranslational modification] 405531001722 intermolecular recognition site; other site 405531001723 dimerization interface [polypeptide binding]; other site 405531001724 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 405531001725 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405531001726 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405531001727 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405531001728 putative NAD(P) binding site [chemical binding]; other site 405531001729 EamA-like transporter family; Region: EamA; pfam00892 405531001730 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531001731 EamA-like transporter family; Region: EamA; pfam00892 405531001732 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531001733 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531001734 DNA-binding site [nucleotide binding]; DNA binding site 405531001735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531001736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531001737 homodimer interface [polypeptide binding]; other site 405531001738 catalytic residue [active] 405531001739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405531001740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531001741 Coenzyme A binding pocket [chemical binding]; other site 405531001742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531001743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531001744 dimerization interface [polypeptide binding]; other site 405531001745 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531001746 dimer interface [polypeptide binding]; other site 405531001747 phosphorylation site [posttranslational modification] 405531001748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531001749 ATP binding site [chemical binding]; other site 405531001750 Mg2+ binding site [ion binding]; other site 405531001751 G-X-G motif; other site 405531001752 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531001753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531001754 active site 405531001755 phosphorylation site [posttranslational modification] 405531001756 intermolecular recognition site; other site 405531001757 dimerization interface [polypeptide binding]; other site 405531001758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531001759 DNA binding site [nucleotide binding] 405531001760 Probable transposase; Region: OrfB_IS605; pfam01385 405531001761 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531001762 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405531001763 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405531001764 Arrestin_N terminal like; Region: LDB19; pfam13002 405531001765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531001766 Coenzyme A binding pocket [chemical binding]; other site 405531001767 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405531001768 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405531001769 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405531001770 catalytic loop [active] 405531001771 iron binding site [ion binding]; other site 405531001772 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405531001773 4Fe-4S binding domain; Region: Fer4; pfam00037 405531001774 4Fe-4S binding domain; Region: Fer4; pfam00037 405531001775 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405531001776 [4Fe-4S] binding site [ion binding]; other site 405531001777 molybdopterin cofactor binding site; other site 405531001778 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405531001779 molybdopterin cofactor binding site; other site 405531001780 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405531001781 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 405531001782 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405531001783 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 405531001784 putative active site [active] 405531001785 catalytic site [active] 405531001786 putative metal binding site [ion binding]; other site 405531001787 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405531001788 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405531001789 hexamer interface [polypeptide binding]; other site 405531001790 ligand binding site [chemical binding]; other site 405531001791 putative active site [active] 405531001792 NAD(P) binding site [chemical binding]; other site 405531001793 amino acid transporter; Region: 2A0306; TIGR00909 405531001794 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405531001795 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531001796 dimerization interface [polypeptide binding]; other site 405531001797 putative DNA binding site [nucleotide binding]; other site 405531001798 putative Zn2+ binding site [ion binding]; other site 405531001799 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405531001800 metal-binding site [ion binding] 405531001801 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405531001802 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405531001803 metal-binding site [ion binding] 405531001804 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531001805 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405531001806 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 405531001807 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 405531001808 active site 405531001809 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531001810 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531001811 non-specific DNA binding site [nucleotide binding]; other site 405531001812 salt bridge; other site 405531001813 sequence-specific DNA binding site [nucleotide binding]; other site 405531001814 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531001815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531001816 binding surface 405531001817 TPR motif; other site 405531001818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531001819 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405531001820 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405531001821 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405531001822 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405531001823 active site 405531001824 Zn binding site [ion binding]; other site 405531001825 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405531001826 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531001827 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405531001828 VanW like protein; Region: VanW; pfam04294 405531001829 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405531001830 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405531001831 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405531001832 Nucleoside recognition; Region: Gate; pfam07670 405531001833 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405531001834 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531001835 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 405531001836 putative metal binding site [ion binding]; other site 405531001837 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405531001838 Domain of unknown function DUF21; Region: DUF21; pfam01595 405531001839 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405531001840 Transporter associated domain; Region: CorC_HlyC; smart01091 405531001841 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 405531001842 Aspartase; Region: Aspartase; cd01357 405531001843 active sites [active] 405531001844 tetramer interface [polypeptide binding]; other site 405531001845 L-lactate permease; Region: Lactate_perm; cl00701 405531001846 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405531001847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531001848 dimerization interface [polypeptide binding]; other site 405531001849 putative Zn2+ binding site [ion binding]; other site 405531001850 putative DNA binding site [nucleotide binding]; other site 405531001851 acid-soluble spore protein H; Provisional; Region: sspH; PRK01625 405531001852 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405531001853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531001854 putative substrate translocation pore; other site 405531001855 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405531001856 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405531001857 siderophore binding site; other site 405531001858 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531001859 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531001860 ABC-ATPase subunit interface; other site 405531001861 dimer interface [polypeptide binding]; other site 405531001862 putative PBP binding regions; other site 405531001863 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531001864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531001865 ABC-ATPase subunit interface; other site 405531001866 dimer interface [polypeptide binding]; other site 405531001867 putative PBP binding regions; other site 405531001868 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405531001869 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405531001870 Walker A/P-loop; other site 405531001871 ATP binding site [chemical binding]; other site 405531001872 Q-loop/lid; other site 405531001873 ABC transporter signature motif; other site 405531001874 Walker B; other site 405531001875 D-loop; other site 405531001876 H-loop/switch region; other site 405531001877 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405531001878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531001879 S-adenosylmethionine binding site [chemical binding]; other site 405531001880 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405531001881 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405531001882 substrate-cofactor binding pocket; other site 405531001883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531001884 catalytic residue [active] 405531001885 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531001886 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 405531001887 NAD binding site [chemical binding]; other site 405531001888 homodimer interface [polypeptide binding]; other site 405531001889 active site 405531001890 putative substrate binding site [chemical binding]; other site 405531001891 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405531001892 nudix motif; other site 405531001893 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 405531001894 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 405531001895 metal ion-dependent adhesion site (MIDAS); other site 405531001896 MoxR-like ATPases [General function prediction only]; Region: COG0714 405531001897 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531001898 Walker A motif; other site 405531001899 ATP binding site [chemical binding]; other site 405531001900 Walker B motif; other site 405531001901 arginine finger; other site 405531001902 cardiolipin synthetase; Reviewed; Region: PRK12452 405531001903 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405531001904 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405531001905 putative active site [active] 405531001906 catalytic site [active] 405531001907 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405531001908 putative active site [active] 405531001909 catalytic site [active] 405531001910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531001911 PAS domain; Region: PAS_9; pfam13426 405531001912 putative active site [active] 405531001913 heme pocket [chemical binding]; other site 405531001914 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531001915 metal binding site [ion binding]; metal-binding site 405531001916 active site 405531001917 I-site; other site 405531001918 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531001919 Amino acid permease; Region: AA_permease_2; pfam13520 405531001920 Spore germination protein; Region: Spore_permease; cl17796 405531001921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531001922 DNA-binding site [nucleotide binding]; DNA binding site 405531001923 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 405531001924 UTRA domain; Region: UTRA; pfam07702 405531001925 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 405531001926 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405531001927 active site turn [active] 405531001928 phosphorylation site [posttranslational modification] 405531001929 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405531001930 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405531001931 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405531001932 Ca binding site [ion binding]; other site 405531001933 active site 405531001934 catalytic site [active] 405531001935 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531001936 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531001937 Spore germination protein; Region: Spore_permease; cl17796 405531001938 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531001939 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531001940 active site 405531001941 ATP binding site [chemical binding]; other site 405531001942 substrate binding site [chemical binding]; other site 405531001943 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531001944 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 405531001945 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405531001946 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405531001947 Walker A/P-loop; other site 405531001948 ATP binding site [chemical binding]; other site 405531001949 Q-loop/lid; other site 405531001950 ABC transporter signature motif; other site 405531001951 Walker B; other site 405531001952 D-loop; other site 405531001953 H-loop/switch region; other site 405531001954 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405531001955 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531001956 substrate binding pocket [chemical binding]; other site 405531001957 membrane-bound complex binding site; other site 405531001958 hinge residues; other site 405531001959 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405531001960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001961 dimer interface [polypeptide binding]; other site 405531001962 conserved gate region; other site 405531001963 putative PBP binding loops; other site 405531001964 ABC-ATPase subunit interface; other site 405531001965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531001966 dimer interface [polypeptide binding]; other site 405531001967 conserved gate region; other site 405531001968 putative PBP binding loops; other site 405531001969 ABC-ATPase subunit interface; other site 405531001970 S-methylmethionine transporter; Provisional; Region: PRK11387 405531001971 OsmC-like protein; Region: OsmC; pfam02566 405531001972 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405531001973 nucleotide binding site/active site [active] 405531001974 HIT family signature motif; other site 405531001975 catalytic residue [active] 405531001976 RNA polymerase sigma factor; Provisional; Region: PRK12542 405531001977 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531001978 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531001979 DNA binding residues [nucleotide binding] 405531001980 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 405531001981 Predicted transcriptional regulator [Transcription]; Region: COG2378 405531001982 HTH domain; Region: HTH_11; pfam08279 405531001983 WYL domain; Region: WYL; pfam13280 405531001984 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405531001985 RibD C-terminal domain; Region: RibD_C; cl17279 405531001986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531001987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531001988 dimerization interface [polypeptide binding]; other site 405531001989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531001990 dimer interface [polypeptide binding]; other site 405531001991 phosphorylation site [posttranslational modification] 405531001992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531001993 ATP binding site [chemical binding]; other site 405531001994 Mg2+ binding site [ion binding]; other site 405531001995 G-X-G motif; other site 405531001996 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531001997 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531001998 active site 405531001999 phosphorylation site [posttranslational modification] 405531002000 intermolecular recognition site; other site 405531002001 dimerization interface [polypeptide binding]; other site 405531002002 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531002003 DNA binding site [nucleotide binding] 405531002004 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 405531002005 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405531002006 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 405531002007 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405531002008 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405531002009 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405531002010 Ligand Binding Site [chemical binding]; other site 405531002011 Protein of unknown function (DUF4027); Region: DUF4027; pfam13219 405531002012 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 405531002013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002014 putative substrate translocation pore; other site 405531002015 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531002016 MarR family; Region: MarR; pfam01047 405531002017 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405531002018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002019 putative substrate translocation pore; other site 405531002020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531002021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531002022 DNA binding site [nucleotide binding] 405531002023 domain linker motif; other site 405531002024 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 405531002025 dimerization interface [polypeptide binding]; other site 405531002026 ligand binding site [chemical binding]; other site 405531002027 sodium binding site [ion binding]; other site 405531002028 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405531002029 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405531002030 substrate binding site [chemical binding]; other site 405531002031 dimer interface [polypeptide binding]; other site 405531002032 ATP binding site [chemical binding]; other site 405531002033 D-ribose pyranase; Provisional; Region: PRK11797 405531002034 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405531002035 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405531002036 Walker A/P-loop; other site 405531002037 ATP binding site [chemical binding]; other site 405531002038 Q-loop/lid; other site 405531002039 ABC transporter signature motif; other site 405531002040 Walker B; other site 405531002041 D-loop; other site 405531002042 H-loop/switch region; other site 405531002043 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405531002044 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405531002045 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405531002046 TM-ABC transporter signature motif; other site 405531002047 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 405531002048 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 405531002049 ligand binding site [chemical binding]; other site 405531002050 dimerization interface [polypeptide binding]; other site 405531002051 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405531002052 active site 405531002053 intersubunit interactions; other site 405531002054 catalytic residue [active] 405531002055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405531002056 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405531002057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531002059 putative substrate translocation pore; other site 405531002060 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405531002061 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 405531002062 putative NAD(P) binding site [chemical binding]; other site 405531002063 catalytic Zn binding site [ion binding]; other site 405531002064 Ion channel; Region: Ion_trans_2; pfam07885 405531002065 Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009 405531002066 Zn binding site [ion binding]; other site 405531002067 Neutral sphingomyelinases (nSMase) catalyze the hydrolysis of sphingomyelin in biological membranes to ceramide and phosphorylcholine; Region: nSMase; cd09078 405531002068 putative catalytic site [active] 405531002069 metal binding site A [ion binding]; metal-binding site 405531002070 phosphate binding site [ion binding]; other site 405531002071 metal binding site C [ion binding]; metal-binding site 405531002072 metal binding site B [ion binding]; metal-binding site 405531002073 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 405531002074 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 405531002075 dimer interface [polypeptide binding]; other site 405531002076 active site 405531002077 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405531002078 substrate binding site [chemical binding]; other site 405531002079 catalytic residue [active] 405531002080 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 405531002081 FAD binding domain; Region: FAD_binding_4; pfam01565 405531002082 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 405531002083 VanZ like family; Region: VanZ; pfam04892 405531002084 RDD family; Region: RDD; pfam06271 405531002085 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 405531002086 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 405531002087 homodimer interface [polypeptide binding]; other site 405531002088 putative GKAP docking site [polypeptide binding]; other site 405531002089 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531002090 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531002091 dimer interface [polypeptide binding]; other site 405531002092 putative CheW interface [polypeptide binding]; other site 405531002093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405531002094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405531002095 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531002096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531002097 non-specific DNA binding site [nucleotide binding]; other site 405531002098 salt bridge; other site 405531002099 sequence-specific DNA binding site [nucleotide binding]; other site 405531002100 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 405531002101 active site 405531002102 catalytic site [active] 405531002103 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405531002104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002105 putative substrate translocation pore; other site 405531002106 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405531002107 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 405531002108 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 405531002109 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 405531002110 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 405531002111 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405531002112 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531002113 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531002114 non-specific DNA binding site [nucleotide binding]; other site 405531002115 salt bridge; other site 405531002116 sequence-specific DNA binding site [nucleotide binding]; other site 405531002117 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531002118 Coenzyme A binding pocket [chemical binding]; other site 405531002119 Protein of unknown function (DUF4022); Region: DUF4022; pfam13214 405531002120 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405531002121 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405531002122 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405531002123 TrkA-N domain; Region: TrkA_N; pfam02254 405531002124 TrkA-C domain; Region: TrkA_C; pfam02080 405531002125 cytochrome aa3 quinol oxidase, subunit IV; Region: QoxD; TIGR02901 405531002126 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405531002127 Subunit I/III interface [polypeptide binding]; other site 405531002128 Subunit III/IV interface [polypeptide binding]; other site 405531002129 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405531002130 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405531002131 D-pathway; other site 405531002132 Putative ubiquinol binding site [chemical binding]; other site 405531002133 Low-spin heme (heme b) binding site [chemical binding]; other site 405531002134 Putative water exit pathway; other site 405531002135 Binuclear center (heme o3/CuB) [ion binding]; other site 405531002136 K-pathway; other site 405531002137 Putative proton exit pathway; other site 405531002138 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 405531002139 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 405531002140 S-methylmethionine transporter; Provisional; Region: PRK11387 405531002141 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405531002142 putative active site [active] 405531002143 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405531002144 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405531002145 metal binding site [ion binding]; metal-binding site 405531002146 dimer interface [polypeptide binding]; other site 405531002147 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 405531002148 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 405531002149 Na binding site [ion binding]; other site 405531002150 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531002151 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405531002152 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531002153 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531002154 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 405531002155 Nucleoside recognition; Region: Gate; pfam07670 405531002156 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405531002157 Nucleoside recognition; Region: Gate; pfam07670 405531002158 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 405531002159 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405531002160 G1 box; other site 405531002161 GTP/Mg2+ binding site [chemical binding]; other site 405531002162 Switch I region; other site 405531002163 G2 box; other site 405531002164 G3 box; other site 405531002165 Switch II region; other site 405531002166 G4 box; other site 405531002167 G5 box; other site 405531002168 FeoA domain; Region: FeoA; pfam04023 405531002169 PBP superfamily domain; Region: PBP_like_2; cl17296 405531002170 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405531002171 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405531002172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002173 dimer interface [polypeptide binding]; other site 405531002174 conserved gate region; other site 405531002175 putative PBP binding loops; other site 405531002176 ABC-ATPase subunit interface; other site 405531002177 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405531002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002179 dimer interface [polypeptide binding]; other site 405531002180 conserved gate region; other site 405531002181 putative PBP binding loops; other site 405531002182 ABC-ATPase subunit interface; other site 405531002183 AAA domain; Region: AAA_33; pfam13671 405531002184 AAA domain; Region: AAA_17; pfam13207 405531002185 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405531002186 Protein export membrane protein; Region: SecD_SecF; cl14618 405531002187 FOG: CBS domain [General function prediction only]; Region: COG0517 405531002188 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 405531002189 Domain of unknown function (DUF3960); Region: DUF3960; pfam13142 405531002190 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 405531002191 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 405531002192 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405531002193 putative active site [active] 405531002194 putative NTP binding site [chemical binding]; other site 405531002195 putative nucleic acid binding site [nucleotide binding]; other site 405531002196 Type II intron maturase; Region: Intron_maturas2; pfam01348 405531002197 Group II catalytic intron 405531002198 Protein of unknown function (DUF3965); Region: DUF3965; pfam13112 405531002199 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531002200 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531002201 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531002202 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531002203 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531002204 Putative transcription activator [Transcription]; Region: TenA; COG0819 405531002205 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405531002206 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405531002207 Walker A/P-loop; other site 405531002208 ATP binding site [chemical binding]; other site 405531002209 Q-loop/lid; other site 405531002210 ABC transporter signature motif; other site 405531002211 Walker B; other site 405531002212 D-loop; other site 405531002213 H-loop/switch region; other site 405531002214 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405531002215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002216 dimer interface [polypeptide binding]; other site 405531002217 conserved gate region; other site 405531002218 putative PBP binding loops; other site 405531002219 ABC-ATPase subunit interface; other site 405531002220 NMT1/THI5 like; Region: NMT1; pfam09084 405531002221 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 405531002222 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405531002223 thiamine phosphate binding site [chemical binding]; other site 405531002224 active site 405531002225 pyrophosphate binding site [ion binding]; other site 405531002226 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 405531002227 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405531002228 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 405531002229 thiS-thiF/thiG interaction site; other site 405531002230 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 405531002231 ThiS interaction site; other site 405531002232 putative active site [active] 405531002233 tetramer interface [polypeptide binding]; other site 405531002234 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 405531002235 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405531002236 ATP binding site [chemical binding]; other site 405531002237 substrate interface [chemical binding]; other site 405531002238 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405531002239 dimer interface [polypeptide binding]; other site 405531002240 substrate binding site [chemical binding]; other site 405531002241 ATP binding site [chemical binding]; other site 405531002242 ydaO/yuaA leader 405531002243 ydaO/yuaA leader 405531002244 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 405531002245 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 405531002246 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531002247 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405531002248 potassium-transporting ATPase subunit C; Provisional; Region: PRK13997 405531002249 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 405531002250 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 405531002251 Ligand Binding Site [chemical binding]; other site 405531002252 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405531002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002254 putative substrate translocation pore; other site 405531002255 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531002256 MarR family; Region: MarR; pfam01047 405531002257 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405531002258 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405531002259 active site 405531002260 nucleophile elbow; other site 405531002261 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405531002262 short chain dehydrogenase; Provisional; Region: PRK06701 405531002263 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 405531002264 NAD binding site [chemical binding]; other site 405531002265 metal binding site [ion binding]; metal-binding site 405531002266 active site 405531002267 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405531002268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405531002269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531002270 catalytic residues [active] 405531002271 putative disulfide oxidoreductase; Provisional; Region: PRK03113 405531002272 YhdB-like protein; Region: YhdB; pfam14148 405531002273 Protein of unknown function with PCYCGC motif; Region: PCYCGC; pfam13798 405531002274 Spore germination protein; Region: Spore_permease; cl17796 405531002275 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531002276 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531002277 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531002278 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 405531002279 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 405531002280 putative FMN binding site [chemical binding]; other site 405531002281 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405531002282 SpoVR like protein; Region: SpoVR; pfam04293 405531002283 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405531002284 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 405531002285 potential frameshift: common BLAST hit: gi|42779936|ref|NP_977183.1| extracellular metalloprotease 405531002286 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 405531002287 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 405531002288 Protein of unknown function (DUF2606); Region: DUF2606; pfam10794 405531002289 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 405531002290 putative homodimer interface [polypeptide binding]; other site 405531002291 putative homotetramer interface [polypeptide binding]; other site 405531002292 putative metal binding site [ion binding]; other site 405531002293 putative homodimer-homodimer interface [polypeptide binding]; other site 405531002294 putative allosteric switch controlling residues; other site 405531002295 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405531002296 CPxP motif; other site 405531002297 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531002298 active site residue [active] 405531002299 Member of the Rhodanese Homology Domain superfamily. This CD includes predicted proteins with rhodanese-like domains found N-terminal of the metallo-beta-lactamase domain; Region: RHOD_Lact_B; cd01523 405531002300 active site residue [active] 405531002301 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405531002302 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 405531002303 CPxP motif; other site 405531002304 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531002305 active site residue [active] 405531002306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531002307 active site residue [active] 405531002308 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 405531002309 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531002310 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405531002311 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 405531002312 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 405531002313 NADP binding site [chemical binding]; other site 405531002314 dimer interface [polypeptide binding]; other site 405531002315 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 405531002316 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405531002317 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405531002318 PhoU domain; Region: PhoU; pfam01895 405531002319 PhoU domain; Region: PhoU; pfam01895 405531002320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531002322 putative substrate translocation pore; other site 405531002323 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405531002324 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405531002325 HTH domain; Region: HTH_11; pfam08279 405531002326 putative frv operon regulatory protein; Provisional; Region: PRK09863 405531002327 Mga helix-turn-helix domain; Region: Mga; pfam05043 405531002328 PRD domain; Region: PRD; pfam00874 405531002329 PRD domain; Region: PRD; pfam00874 405531002330 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 405531002331 active site 405531002332 P-loop; other site 405531002333 phosphorylation site [posttranslational modification] 405531002334 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405531002335 active site 405531002336 phosphorylation site [posttranslational modification] 405531002337 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405531002338 active site 405531002339 methionine cluster; other site 405531002340 phosphorylation site [posttranslational modification] 405531002341 metal binding site [ion binding]; metal-binding site 405531002342 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405531002343 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405531002344 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405531002345 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405531002346 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405531002347 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531002348 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531002349 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405531002350 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405531002351 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531002352 FtsX-like permease family; Region: FtsX; pfam02687 405531002353 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531002354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531002355 Walker A/P-loop; other site 405531002356 ATP binding site [chemical binding]; other site 405531002357 Q-loop/lid; other site 405531002358 ABC transporter signature motif; other site 405531002359 Walker B; other site 405531002360 D-loop; other site 405531002361 H-loop/switch region; other site 405531002362 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405531002363 HlyD family secretion protein; Region: HlyD_3; pfam13437 405531002364 conserved hypothetical integral membrane protein TIGR02206; Region: intg_mem_TP0381 405531002365 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 405531002366 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405531002367 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405531002368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002369 dimer interface [polypeptide binding]; other site 405531002370 conserved gate region; other site 405531002371 ABC-ATPase subunit interface; other site 405531002372 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405531002373 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 405531002374 dimanganese center [ion binding]; other site 405531002375 CotJB protein; Region: CotJB; pfam12652 405531002376 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 405531002377 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531002378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531002379 active site 405531002380 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405531002381 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405531002382 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 405531002383 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 405531002384 putative DNA binding site [nucleotide binding]; other site 405531002385 putative homodimer interface [polypeptide binding]; other site 405531002386 yybP-ykoY leader 405531002387 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405531002388 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531002389 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531002390 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405531002391 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405531002392 Protein of unknown function (DUF3992); Region: DUF3992; pfam13157 405531002393 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531002394 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405531002395 active site 405531002396 metal binding site [ion binding]; metal-binding site 405531002397 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531002398 Interdomain contacts; other site 405531002399 Cytokine receptor motif; other site 405531002400 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405531002401 amino acid transporter; Region: 2A0306; TIGR00909 405531002402 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405531002403 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405531002404 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405531002405 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405531002406 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405531002407 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405531002408 putative active site [active] 405531002409 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 405531002410 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 405531002411 putative active site [active] 405531002412 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405531002413 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 405531002414 active site turn [active] 405531002415 phosphorylation site [posttranslational modification] 405531002416 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405531002417 Uncharacterized conserved protein [Function unknown]; Region: COG3589 405531002418 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 405531002419 DoxX; Region: DoxX; pfam07681 405531002420 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 405531002421 hypothetical protein; Provisional; Region: PRK06770 405531002422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531002423 EamA-like transporter family; Region: EamA; pfam00892 405531002424 EamA-like transporter family; Region: EamA; pfam00892 405531002425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405531002426 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 405531002427 AsnC family; Region: AsnC_trans_reg; pfam01037 405531002428 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531002429 Coenzyme A binding pocket [chemical binding]; other site 405531002430 short chain dehydrogenase; Provisional; Region: PRK06138 405531002431 classical (c) SDRs; Region: SDR_c; cd05233 405531002432 NAD(P) binding site [chemical binding]; other site 405531002433 active site 405531002434 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531002435 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405531002436 DNA binding residues [nucleotide binding] 405531002437 putative dimer interface [polypeptide binding]; other site 405531002438 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531002439 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531002440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531002441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531002442 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531002444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002445 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531002446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531002447 dimerization interface [polypeptide binding]; other site 405531002448 putative DNA binding site [nucleotide binding]; other site 405531002449 putative Zn2+ binding site [ion binding]; other site 405531002450 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 405531002451 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405531002452 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405531002453 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405531002454 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 405531002455 proposed catalytic triad [active] 405531002456 conserved cys residue [active] 405531002457 hydroperoxidase II; Provisional; Region: katE; PRK11249 405531002458 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 405531002459 tetramer interface [polypeptide binding]; other site 405531002460 heme binding pocket [chemical binding]; other site 405531002461 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 405531002462 domain interactions; other site 405531002463 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405531002464 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405531002465 Spore germination protein; Region: Spore_permease; cl17796 405531002466 Lysine riboswitch 405531002467 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 405531002468 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 405531002469 tetrameric interface [polypeptide binding]; other site 405531002470 activator binding site; other site 405531002471 NADP binding site [chemical binding]; other site 405531002472 substrate binding site [chemical binding]; other site 405531002473 catalytic residues [active] 405531002474 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405531002475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531002476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531002477 Walker A/P-loop; other site 405531002478 ATP binding site [chemical binding]; other site 405531002479 Q-loop/lid; other site 405531002480 ABC transporter signature motif; other site 405531002481 Walker B; other site 405531002482 D-loop; other site 405531002483 H-loop/switch region; other site 405531002484 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531002485 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 405531002486 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405531002487 Walker A/P-loop; other site 405531002488 ATP binding site [chemical binding]; other site 405531002489 Q-loop/lid; other site 405531002490 ABC transporter signature motif; other site 405531002491 Walker B; other site 405531002492 D-loop; other site 405531002493 H-loop/switch region; other site 405531002494 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405531002495 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531002496 substrate binding pocket [chemical binding]; other site 405531002497 membrane-bound complex binding site; other site 405531002498 hinge residues; other site 405531002499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002500 dimer interface [polypeptide binding]; other site 405531002501 conserved gate region; other site 405531002502 putative PBP binding loops; other site 405531002503 ABC-ATPase subunit interface; other site 405531002504 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405531002505 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405531002506 Walker A/P-loop; other site 405531002507 ATP binding site [chemical binding]; other site 405531002508 Q-loop/lid; other site 405531002509 ABC transporter signature motif; other site 405531002510 Walker B; other site 405531002511 D-loop; other site 405531002512 H-loop/switch region; other site 405531002513 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531002514 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405531002515 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 405531002516 Protein of unknown function (DUF445); Region: DUF445; pfam04286 405531002517 hypothetical protein; Provisional; Region: PRK13676 405531002518 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 405531002519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531002520 Histidine kinase; Region: HisKA_3; pfam07730 405531002521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531002522 ATP binding site [chemical binding]; other site 405531002523 Mg2+ binding site [ion binding]; other site 405531002524 G-X-G motif; other site 405531002525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531002526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531002527 active site 405531002528 phosphorylation site [posttranslational modification] 405531002529 intermolecular recognition site; other site 405531002530 dimerization interface [polypeptide binding]; other site 405531002531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531002532 DNA binding residues [nucleotide binding] 405531002533 dimerization interface [polypeptide binding]; other site 405531002534 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 405531002535 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405531002536 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405531002537 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405531002538 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 405531002539 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 405531002540 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405531002541 acetolactate synthase; Reviewed; Region: PRK08617 405531002542 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405531002543 PYR/PP interface [polypeptide binding]; other site 405531002544 dimer interface [polypeptide binding]; other site 405531002545 TPP binding site [chemical binding]; other site 405531002546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405531002547 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 405531002548 TPP-binding site [chemical binding]; other site 405531002549 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 405531002550 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 405531002551 active site 405531002552 DNA binding site [nucleotide binding] 405531002553 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 405531002554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405531002555 active site 405531002556 motif I; other site 405531002557 motif II; other site 405531002558 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405531002559 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 405531002560 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 405531002561 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002562 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002563 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002564 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002565 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002566 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002567 Cna protein B-type domain; Region: Cna_B; pfam05738 405531002568 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531002569 amidase catalytic site [active] 405531002570 Zn binding residues [ion binding]; other site 405531002571 substrate binding site [chemical binding]; other site 405531002572 S-layer homology domain; Region: SLH; pfam00395 405531002573 S-layer homology domain; Region: SLH; pfam00395 405531002574 coproporphyrinogen III oxidase; Provisional; Region: PRK08207 405531002575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531002576 FeS/SAM binding site; other site 405531002577 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405531002578 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405531002579 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 405531002580 acyl-activating enzyme (AAE) consensus motif; other site 405531002581 acyl-activating enzyme (AAE) consensus motif; other site 405531002582 putative AMP binding site [chemical binding]; other site 405531002583 putative active site [active] 405531002584 putative CoA binding site [chemical binding]; other site 405531002585 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 405531002586 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405531002587 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405531002588 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405531002589 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405531002590 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 405531002591 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 405531002592 S-layer homology domain; Region: SLH; pfam00395 405531002593 S-layer homology domain; Region: SLH; pfam00395 405531002594 S-layer homology domain; Region: SLH; pfam00395 405531002595 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405531002596 O-Antigen ligase; Region: Wzy_C; cl04850 405531002597 enoyl-CoA hydratase; Provisional; Region: PRK07659 405531002598 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405531002599 substrate binding site [chemical binding]; other site 405531002600 oxyanion hole (OAH) forming residues; other site 405531002601 trimer interface [polypeptide binding]; other site 405531002602 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 405531002603 metal binding site [ion binding]; metal-binding site 405531002604 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405531002605 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 405531002606 putative oligomer interface [polypeptide binding]; other site 405531002607 putative active site [active] 405531002608 metal binding site [ion binding]; metal-binding site 405531002609 S-layer homology domain; Region: SLH; pfam00395 405531002610 S-layer homology domain; Region: SLH; pfam00395 405531002611 S-layer homology domain; Region: SLH; pfam00395 405531002612 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405531002613 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405531002614 active site 405531002615 metal binding site [ion binding]; metal-binding site 405531002616 Predicted DNA modification methylase [DNA replication, recombination, and repair]; Region: COG1041 405531002617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531002618 S-adenosylmethionine binding site [chemical binding]; other site 405531002619 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405531002620 proline racemase; Provisional; Region: PRK13969 405531002621 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405531002622 ornithine cyclodeaminase; Validated; Region: PRK08618 405531002623 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405531002624 NAD(P) binding site [chemical binding]; other site 405531002625 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405531002626 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 405531002627 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405531002628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002629 dimer interface [polypeptide binding]; other site 405531002630 conserved gate region; other site 405531002631 putative PBP binding loops; other site 405531002632 ABC-ATPase subunit interface; other site 405531002633 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405531002634 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405531002635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531002636 dimer interface [polypeptide binding]; other site 405531002637 conserved gate region; other site 405531002638 putative PBP binding loops; other site 405531002639 ABC-ATPase subunit interface; other site 405531002640 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405531002641 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531002642 Walker A/P-loop; other site 405531002643 ATP binding site [chemical binding]; other site 405531002644 Q-loop/lid; other site 405531002645 ABC transporter signature motif; other site 405531002646 Walker B; other site 405531002647 D-loop; other site 405531002648 H-loop/switch region; other site 405531002649 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405531002650 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 405531002651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531002652 Walker A/P-loop; other site 405531002653 ATP binding site [chemical binding]; other site 405531002654 Q-loop/lid; other site 405531002655 ABC transporter signature motif; other site 405531002656 Walker B; other site 405531002657 D-loop; other site 405531002658 H-loop/switch region; other site 405531002659 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405531002660 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 405531002661 catalytic residues [active] 405531002662 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405531002663 SnoaL-like domain; Region: SnoaL_2; pfam12680 405531002664 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 405531002665 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531002666 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405531002667 acyl-activating enzyme (AAE) consensus motif; other site 405531002668 AMP binding site [chemical binding]; other site 405531002669 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531002670 Condensation domain; Region: Condensation; pfam00668 405531002671 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531002672 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531002673 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531002674 acyl-activating enzyme (AAE) consensus motif; other site 405531002675 AMP binding site [chemical binding]; other site 405531002676 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531002677 thioester reductase domain; Region: Thioester-redct; TIGR01746 405531002678 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531002679 NAD(P) binding site [chemical binding]; other site 405531002680 active site 405531002681 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 405531002682 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 405531002683 tetramer interface [polypeptide binding]; other site 405531002684 active site 405531002685 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 405531002686 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405531002687 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405531002688 tetramer interface [polypeptide binding]; other site 405531002689 active site 405531002690 Mg2+/Mn2+ binding site [ion binding]; other site 405531002691 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 405531002692 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 405531002693 ATP binding site [chemical binding]; other site 405531002694 substrate interface [chemical binding]; other site 405531002695 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531002696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002697 putative substrate translocation pore; other site 405531002698 DinB family; Region: DinB; cl17821 405531002699 DinB superfamily; Region: DinB_2; pfam12867 405531002700 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405531002701 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531002702 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405531002703 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531002704 HTH-like domain; Region: HTH_21; pfam13276 405531002705 Integrase core domain; Region: rve; pfam00665 405531002706 Integrase core domain; Region: rve_2; pfam13333 405531002707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 405531002708 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 405531002709 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 405531002710 LXG domain of WXG superfamily; Region: LXG; pfam04740 405531002711 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 405531002712 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405531002713 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405531002714 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 405531002715 Yip1 domain; Region: Yip1; pfam04893 405531002716 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 405531002717 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405531002718 active site 405531002719 Int/Topo IB signature motif; other site 405531002720 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 405531002721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002722 putative substrate translocation pore; other site 405531002723 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 405531002724 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531002725 putative active site [active] 405531002726 heme pocket [chemical binding]; other site 405531002727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531002728 ATP binding site [chemical binding]; other site 405531002729 Mg2+ binding site [ion binding]; other site 405531002730 G-X-G motif; other site 405531002731 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 405531002732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531002733 active site 405531002734 phosphorylation site [posttranslational modification] 405531002735 intermolecular recognition site; other site 405531002736 dimerization interface [polypeptide binding]; other site 405531002737 HTH domain; Region: HTH_11; cl17392 405531002738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 405531002739 Restriction endonuclease; Region: Mrr_cat; pfam04471 405531002740 potential frameshift: common BLAST hit: gi|120403203|ref|YP_953032.1| RNA-directed DNA polymerase 405531002741 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405531002742 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405531002743 putative nucleic acid binding site [nucleotide binding]; other site 405531002744 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 405531002745 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 405531002746 Group II catalytic intron 405531002747 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 405531002748 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531002749 cofactor binding site; other site 405531002750 DNA binding site [nucleotide binding] 405531002751 substrate interaction site [chemical binding]; other site 405531002752 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531002753 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531002754 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 405531002755 cofactor binding site; other site 405531002756 DNA binding site [nucleotide binding] 405531002757 substrate interaction site [chemical binding]; other site 405531002758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405531002759 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 405531002760 AIPR protein; Region: AIPR; pfam10592 405531002761 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405531002762 replicative DNA helicase; Provisional; Region: PRK06749 405531002763 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405531002764 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405531002765 Walker A motif; other site 405531002766 ATP binding site [chemical binding]; other site 405531002767 Walker B motif; other site 405531002768 DNA binding loops [nucleotide binding] 405531002769 Uncharacterized conserved protein [Function unknown]; Region: COG5464 405531002770 Predicted transcriptional regulators [Transcription]; Region: COG1378 405531002771 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405531002772 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405531002773 C-terminal domain interface [polypeptide binding]; other site 405531002774 sugar binding site [chemical binding]; other site 405531002775 hypothetical protein; Provisional; Region: PRK10621 405531002776 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531002777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531002778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531002779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002780 putative substrate translocation pore; other site 405531002781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002782 hypothetical protein; Provisional; Region: PRK06770 405531002783 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531002784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531002785 Short C-terminal domain; Region: SHOCT; pfam09851 405531002786 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 405531002787 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 405531002788 active site 405531002789 catalytic site [active] 405531002790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531002791 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531002792 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405531002793 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405531002794 putative pectinesterase; Region: PLN02432; cl01911 405531002795 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 405531002796 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405531002797 CGNR zinc finger; Region: zf-CGNR; pfam11706 405531002798 HPP family; Region: HPP; pfam04982 405531002799 YmzC-like protein; Region: YmzC; pfam14157 405531002800 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405531002801 nudix motif; other site 405531002802 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405531002803 MarR family; Region: MarR_2; pfam12802 405531002804 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405531002805 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405531002806 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405531002807 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405531002808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002809 putative substrate translocation pore; other site 405531002810 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531002811 putative DNA binding site [nucleotide binding]; other site 405531002812 dimerization interface [polypeptide binding]; other site 405531002813 putative Zn2+ binding site [ion binding]; other site 405531002814 VanZ like family; Region: VanZ; pfam04892 405531002815 DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483 405531002816 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 405531002817 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405531002818 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531002819 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405531002820 dihydroxyacetone kinase; Provisional; Region: PRK14479 405531002821 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 405531002822 DAK2 domain; Region: Dak2; pfam02734 405531002823 Bacterial SH3 domain; Region: SH3_3; cl17532 405531002824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531002825 non-specific DNA binding site [nucleotide binding]; other site 405531002826 salt bridge; other site 405531002827 sequence-specific DNA binding site [nucleotide binding]; other site 405531002828 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531002829 S-layer homology domain; Region: SLH; pfam00395 405531002830 S-layer homology domain; Region: SLH; pfam00395 405531002831 S-layer homology domain; Region: SLH; pfam00395 405531002832 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405531002833 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531002834 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531002835 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405531002836 Putative zinc-finger; Region: zf-HC2; pfam13490 405531002837 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405531002838 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 405531002839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531002840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531002841 DNA binding residues [nucleotide binding] 405531002842 Heat induced stress protein YflT; Region: YflT; pfam11181 405531002843 Predicted membrane protein [Function unknown]; Region: COG2261 405531002844 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 405531002845 anti sigma factor interaction site; other site 405531002846 regulatory phosphorylation site [posttranslational modification]; other site 405531002847 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405531002848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531002849 ATP binding site [chemical binding]; other site 405531002850 Mg2+ binding site [ion binding]; other site 405531002851 G-X-G motif; other site 405531002852 RNA polymerase sigma-B factor; Region: Sigma_B; TIGR02941 405531002853 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531002854 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405531002855 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531002856 DNA binding residues [nucleotide binding] 405531002857 Ferritin-like domain; Region: Ferritin; pfam00210 405531002858 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405531002859 dinuclear metal binding motif [ion binding]; other site 405531002860 Response regulator receiver domain; Region: Response_reg; pfam00072 405531002861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531002862 active site 405531002863 phosphorylation site [posttranslational modification] 405531002864 intermolecular recognition site; other site 405531002865 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 405531002866 dimerization interface [polypeptide binding]; other site 405531002867 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 405531002868 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405531002869 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405531002870 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 405531002871 CHASE3 domain; Region: CHASE3; pfam05227 405531002872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 405531002873 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405531002874 GAF domain; Region: GAF; pfam01590 405531002875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531002876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531002877 dimer interface [polypeptide binding]; other site 405531002878 phosphorylation site [posttranslational modification] 405531002879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531002880 ATP binding site [chemical binding]; other site 405531002881 Mg2+ binding site [ion binding]; other site 405531002882 G-X-G motif; other site 405531002883 Response regulator receiver domain; Region: Response_reg; pfam00072 405531002884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531002885 active site 405531002886 phosphorylation site [posttranslational modification] 405531002887 intermolecular recognition site; other site 405531002888 dimerization interface [polypeptide binding]; other site 405531002889 regulatory protein interface [polypeptide binding]; other site 405531002890 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 405531002891 regulatory phosphorylation site [posttranslational modification]; other site 405531002892 Protein of unknown function (DUF4028); Region: DUF4028; pfam13220 405531002893 hypothetical protein; Provisional; Region: PRK12856 405531002894 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 405531002895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531002896 putative substrate translocation pore; other site 405531002897 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405531002898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531002899 DNA-binding site [nucleotide binding]; DNA binding site 405531002900 FCD domain; Region: FCD; pfam07729 405531002901 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 405531002902 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405531002903 NADP binding site [chemical binding]; other site 405531002904 dimer interface [polypeptide binding]; other site 405531002905 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 405531002906 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 405531002907 active site 405531002908 Protein of unknown function (DUF2639); Region: DUF2639; pfam11121 405531002909 YhzD-like protein; Region: YhzD; pfam14120 405531002910 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405531002911 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531002912 active site 405531002913 metal binding site [ion binding]; metal-binding site 405531002914 DNA binding site [nucleotide binding] 405531002915 AAA domain; Region: AAA_27; pfam13514 405531002916 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 405531002917 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 405531002918 generic binding surface II; other site 405531002919 generic binding surface I; other site 405531002920 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531002921 Zn2+ binding site [ion binding]; other site 405531002922 Mg2+ binding site [ion binding]; other site 405531002923 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 405531002924 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 405531002925 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405531002926 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531002927 Zn binding site [ion binding]; other site 405531002928 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405531002929 Zn binding site [ion binding]; other site 405531002930 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405531002931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531002932 Zn binding site [ion binding]; other site 405531002933 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405531002934 Zn binding site [ion binding]; other site 405531002935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531002936 TPR motif; other site 405531002937 binding surface 405531002938 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531002939 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405531002940 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 405531002941 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405531002942 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 405531002943 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 405531002944 Cupin; Region: Cupin_1; smart00835 405531002945 Cupin; Region: Cupin_1; smart00835 405531002946 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531002947 non-specific DNA binding site [nucleotide binding]; other site 405531002948 salt bridge; other site 405531002949 sequence-specific DNA binding site [nucleotide binding]; other site 405531002950 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 405531002951 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 405531002952 amphipathic channel; other site 405531002953 Asn-Pro-Ala signature motifs; other site 405531002954 glycerol kinase; Provisional; Region: glpK; PRK00047 405531002955 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 405531002956 N- and C-terminal domain interface [polypeptide binding]; other site 405531002957 active site 405531002958 MgATP binding site [chemical binding]; other site 405531002959 catalytic site [active] 405531002960 metal binding site [ion binding]; metal-binding site 405531002961 glycerol binding site [chemical binding]; other site 405531002962 homotetramer interface [polypeptide binding]; other site 405531002963 homodimer interface [polypeptide binding]; other site 405531002964 FBP binding site [chemical binding]; other site 405531002965 protein IIAGlc interface [polypeptide binding]; other site 405531002966 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 405531002967 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 405531002968 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531002969 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531002970 DNA binding residues [nucleotide binding] 405531002971 lineage-specific thermal regulator protein; Provisional; Region: lstR; PRK09416 405531002972 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531002973 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405531002974 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405531002975 Part of AAA domain; Region: AAA_19; pfam13245 405531002976 Family description; Region: UvrD_C_2; pfam13538 405531002977 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405531002978 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405531002979 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 405531002980 transcriptional regulator Hpr; Provisional; Region: PRK13777 405531002981 MarR family; Region: MarR; pfam01047 405531002982 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 405531002983 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 405531002984 HIT family signature motif; other site 405531002985 catalytic residue [active] 405531002986 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405531002987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531002988 Walker A/P-loop; other site 405531002989 ATP binding site [chemical binding]; other site 405531002990 Q-loop/lid; other site 405531002991 ABC transporter signature motif; other site 405531002992 Walker B; other site 405531002993 D-loop; other site 405531002994 H-loop/switch region; other site 405531002995 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405531002996 EcsC protein family; Region: EcsC; pfam12787 405531002997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531002998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531002999 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405531003000 Predicted membrane protein [Function unknown]; Region: COG3428 405531003001 Bacterial PH domain; Region: DUF304; pfam03703 405531003002 Bacterial PH domain; Region: DUF304; cl01348 405531003003 Bacterial PH domain; Region: DUF304; pfam03703 405531003004 Protein of unknown function (DUF975); Region: DUF975; cl10504 405531003005 Protein of unknown function (DUF975); Region: DUF975; cl10504 405531003006 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 405531003007 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531003008 Collagen binding domain; Region: Collagen_bind; pfam05737 405531003009 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405531003010 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003011 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003012 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003013 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003014 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003015 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003016 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003017 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003018 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003019 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003020 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003021 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003022 Cna protein B-type domain; Region: Cna_B; pfam05738 405531003023 Biofilm formation and stress response factor; Region: BsmA; pfam10014 405531003024 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 405531003025 classical (c) SDRs; Region: SDR_c; cd05233 405531003026 NAD(P) binding site [chemical binding]; other site 405531003027 active site 405531003028 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531003029 EamA-like transporter family; Region: EamA; pfam00892 405531003030 EamA-like transporter family; Region: EamA; cl17759 405531003031 Uncharacterized conserved protein [Function unknown]; Region: COG3402 405531003032 Bacterial PH domain; Region: DUF304; pfam03703 405531003033 Bacterial PH domain; Region: DUF304; pfam03703 405531003034 Bacterial PH domain; Region: DUF304; pfam03703 405531003035 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405531003036 Transglycosylase; Region: Transgly; pfam00912 405531003037 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405531003038 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531003039 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 405531003040 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 405531003041 substrate binding site [chemical binding]; other site 405531003042 active site 405531003043 ferrochelatase; Provisional; Region: PRK12435 405531003044 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405531003045 C-terminal domain interface [polypeptide binding]; other site 405531003046 active site 405531003047 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405531003048 active site 405531003049 N-terminal domain interface [polypeptide binding]; other site 405531003050 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 405531003051 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531003052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531003053 Protein of unknown function (DUF4026); Region: DUF4026; pfam13218 405531003054 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 405531003055 Fn3 associated; Region: Fn3_assoc; pfam13287 405531003056 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 405531003057 generic binding surface II; other site 405531003058 generic binding surface I; other site 405531003059 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 405531003060 putative active site [active] 405531003061 putative catalytic site [active] 405531003062 putative Mg binding site IVb [ion binding]; other site 405531003063 putative phosphate binding site [ion binding]; other site 405531003064 putative DNA binding site [nucleotide binding]; other site 405531003065 putative Mg binding site IVa [ion binding]; other site 405531003066 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531003067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531003068 Predicted membrane protein [Function unknown]; Region: COG1511 405531003069 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405531003070 Predicted membrane protein [Function unknown]; Region: COG1511 405531003071 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405531003072 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 405531003073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531003074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531003075 Coenzyme A binding pocket [chemical binding]; other site 405531003076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531003077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531003078 DNA binding site [nucleotide binding] 405531003079 domain linker motif; other site 405531003080 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405531003081 putative dimerization interface [polypeptide binding]; other site 405531003082 putative ligand binding site [chemical binding]; other site 405531003083 YhfH-like protein; Region: YhfH; pfam14149 405531003084 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 405531003085 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405531003086 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 405531003087 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 405531003088 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 405531003089 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405531003090 acyl-activating enzyme (AAE) consensus motif; other site 405531003091 putative AMP binding site [chemical binding]; other site 405531003092 putative active site [active] 405531003093 putative CoA binding site [chemical binding]; other site 405531003094 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405531003095 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531003096 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531003097 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531003098 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531003099 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405531003100 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531003101 putative active site [active] 405531003102 putative metal binding site [ion binding]; other site 405531003103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531003104 Zn2+ binding site [ion binding]; other site 405531003105 Mg2+ binding site [ion binding]; other site 405531003106 Poxvirus C7/F8A protein; Region: Pox_C7_F8A; cl17263 405531003107 Putative zinc-finger; Region: zf-HC2; pfam13490 405531003108 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 405531003109 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405531003110 RNA polymerase sigma factor; Provisional; Region: PRK12541 405531003111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531003112 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531003113 DNA binding residues [nucleotide binding] 405531003114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531003115 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405531003116 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531003117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405531003118 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531003119 active site 405531003120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531003121 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531003122 dimer interface [polypeptide binding]; other site 405531003123 phosphorylation site [posttranslational modification] 405531003124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531003125 ATP binding site [chemical binding]; other site 405531003126 Mg2+ binding site [ion binding]; other site 405531003127 G-X-G motif; other site 405531003128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531003129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531003130 active site 405531003131 phosphorylation site [posttranslational modification] 405531003132 intermolecular recognition site; other site 405531003133 dimerization interface [polypeptide binding]; other site 405531003134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531003135 DNA binding site [nucleotide binding] 405531003136 CAAX protease self-immunity; Region: Abi; pfam02517 405531003137 Peptidase family M48; Region: Peptidase_M48; pfam01435 405531003138 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 405531003139 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531003140 dimerization interface [polypeptide binding]; other site 405531003141 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531003142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531003143 dimer interface [polypeptide binding]; other site 405531003144 putative CheW interface [polypeptide binding]; other site 405531003145 EamA-like transporter family; Region: EamA; cl17759 405531003146 S-layer homology domain; Region: SLH; pfam00395 405531003147 S-layer homology domain; Region: SLH; pfam00395 405531003148 S-layer homology domain; Region: SLH; pfam00395 405531003149 S-layer homology domain; Region: SLH; pfam00395 405531003150 S-layer homology domain; Region: SLH; pfam00395 405531003151 S-layer homology domain; Region: SLH; pfam00395 405531003152 malate synthase A; Region: malate_syn_A; TIGR01344 405531003153 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 405531003154 active site 405531003155 isocitrate lyase; Provisional; Region: PRK15063 405531003156 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405531003157 tetramer interface [polypeptide binding]; other site 405531003158 active site 405531003159 Mg2+/Mn2+ binding site [ion binding]; other site 405531003160 Phosphotransferase enzyme family; Region: APH; pfam01636 405531003161 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405531003162 active site 405531003163 substrate binding site [chemical binding]; other site 405531003164 ATP binding site [chemical binding]; other site 405531003165 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531003166 DNA-binding site [nucleotide binding]; DNA binding site 405531003167 RNA-binding motif; other site 405531003168 ComK protein; Region: ComK; pfam06338 405531003169 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405531003170 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531003171 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531003172 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531003173 Catalytic site [active] 405531003174 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531003175 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 405531003176 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405531003177 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 405531003178 Part of AAA domain; Region: AAA_19; pfam13245 405531003179 Family description; Region: UvrD_C_2; pfam13538 405531003180 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 405531003181 hypothetical protein; Provisional; Region: PRK07758 405531003182 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405531003183 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 405531003184 Spore germination protein GerPC; Region: GerPC; pfam10737 405531003185 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 405531003186 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405531003187 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405531003188 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405531003189 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 405531003190 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 405531003191 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531003192 inhibitor-cofactor binding pocket; inhibition site 405531003193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531003194 catalytic residue [active] 405531003195 hypothetical protein; Provisional; Region: PRK13673 405531003196 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 405531003197 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405531003198 active site 405531003199 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405531003200 dimer interface [polypeptide binding]; other site 405531003201 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405531003202 Ligand Binding Site [chemical binding]; other site 405531003203 Molecular Tunnel; other site 405531003204 ferrochelatase; Provisional; Region: PRK12435 405531003205 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405531003206 C-terminal domain interface [polypeptide binding]; other site 405531003207 active site 405531003208 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405531003209 active site 405531003210 N-terminal domain interface [polypeptide binding]; other site 405531003211 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405531003212 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405531003213 tetramer interface [polypeptide binding]; other site 405531003214 heme binding pocket [chemical binding]; other site 405531003215 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 405531003216 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 405531003217 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 405531003218 active site 405531003219 catalytic site [active] 405531003220 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531003221 non-specific DNA binding site [nucleotide binding]; other site 405531003222 salt bridge; other site 405531003223 sequence-specific DNA binding site [nucleotide binding]; other site 405531003224 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531003225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 405531003226 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 405531003227 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 405531003228 S1 domain; Region: S1_2; pfam13509 405531003229 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405531003230 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405531003231 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531003232 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531003233 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531003234 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 405531003235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531003236 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531003237 active site 405531003238 motif I; other site 405531003239 motif II; other site 405531003240 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405531003241 YjzC-like protein; Region: YjzC; pfam14168 405531003242 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 405531003243 Clp amino terminal domain; Region: Clp_N; pfam02861 405531003244 Clp amino terminal domain; Region: Clp_N; pfam02861 405531003245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531003246 Walker A motif; other site 405531003247 ATP binding site [chemical binding]; other site 405531003248 Walker B motif; other site 405531003249 arginine finger; other site 405531003250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531003251 Walker A motif; other site 405531003252 ATP binding site [chemical binding]; other site 405531003253 Walker B motif; other site 405531003254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405531003255 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 405531003256 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531003257 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531003258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531003259 ComZ; Region: ComZ; pfam10815 405531003260 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 405531003261 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405531003262 dimer interface [polypeptide binding]; other site 405531003263 active site 405531003264 CoA binding pocket [chemical binding]; other site 405531003265 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 405531003266 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405531003267 dimer interface [polypeptide binding]; other site 405531003268 active site 405531003269 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 405531003270 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 405531003271 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405531003272 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405531003273 active site 405531003274 HIGH motif; other site 405531003275 dimer interface [polypeptide binding]; other site 405531003276 KMSKS motif; other site 405531003277 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 405531003278 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531003279 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531003280 peptide binding site [polypeptide binding]; other site 405531003281 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405531003282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531003283 dimer interface [polypeptide binding]; other site 405531003284 conserved gate region; other site 405531003285 putative PBP binding loops; other site 405531003286 ABC-ATPase subunit interface; other site 405531003287 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405531003288 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 405531003289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531003290 dimer interface [polypeptide binding]; other site 405531003291 conserved gate region; other site 405531003292 putative PBP binding loops; other site 405531003293 ABC-ATPase subunit interface; other site 405531003294 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 405531003295 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531003296 Walker A/P-loop; other site 405531003297 ATP binding site [chemical binding]; other site 405531003298 Q-loop/lid; other site 405531003299 ABC transporter signature motif; other site 405531003300 Walker B; other site 405531003301 D-loop; other site 405531003302 H-loop/switch region; other site 405531003303 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405531003304 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405531003305 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405531003306 Walker A/P-loop; other site 405531003307 ATP binding site [chemical binding]; other site 405531003308 Q-loop/lid; other site 405531003309 ABC transporter signature motif; other site 405531003310 Walker B; other site 405531003311 D-loop; other site 405531003312 H-loop/switch region; other site 405531003313 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405531003314 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405531003315 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 405531003316 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531003317 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531003318 peptide binding site [polypeptide binding]; other site 405531003319 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405531003320 ArsC family; Region: ArsC; pfam03960 405531003321 putative catalytic residues [active] 405531003322 thiol/disulfide switch; other site 405531003323 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405531003324 adaptor protein; Provisional; Region: PRK02315 405531003325 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 405531003326 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405531003327 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405531003328 putative active site [active] 405531003329 catalytic site [active] 405531003330 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405531003331 putative active site [active] 405531003332 catalytic site [active] 405531003333 Competence protein CoiA-like family; Region: CoiA; cl11541 405531003334 oligoendopeptidase F; Region: pepF; TIGR00181 405531003335 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405531003336 active site 405531003337 Zn binding site [ion binding]; other site 405531003338 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405531003339 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 405531003340 catalytic residues [active] 405531003341 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 405531003342 apolar tunnel; other site 405531003343 heme binding site [chemical binding]; other site 405531003344 dimerization interface [polypeptide binding]; other site 405531003345 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 405531003346 putative active site [active] 405531003347 putative metal binding residues [ion binding]; other site 405531003348 signature motif; other site 405531003349 putative triphosphate binding site [ion binding]; other site 405531003350 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405531003351 synthetase active site [active] 405531003352 NTP binding site [chemical binding]; other site 405531003353 metal binding site [ion binding]; metal-binding site 405531003354 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 405531003355 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405531003356 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405531003357 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405531003358 active site 405531003359 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 405531003360 trimer interface [polypeptide binding]; other site 405531003361 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 405531003362 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 405531003363 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 405531003364 active site 405531003365 metal binding site [ion binding]; metal-binding site 405531003366 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405531003367 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405531003368 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405531003369 active site 405531003370 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531003371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531003372 S-adenosylmethionine binding site [chemical binding]; other site 405531003373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405531003374 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 405531003375 putative metal binding site; other site 405531003376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531003377 binding surface 405531003378 TPR motif; other site 405531003379 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531003380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531003381 S-adenosylmethionine binding site [chemical binding]; other site 405531003382 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 405531003383 catalytic residues [active] 405531003384 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405531003385 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 405531003386 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405531003387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531003388 active site 405531003389 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 405531003390 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 405531003391 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 405531003392 NAD binding site [chemical binding]; other site 405531003393 substrate binding site [chemical binding]; other site 405531003394 homodimer interface [polypeptide binding]; other site 405531003395 active site 405531003396 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 405531003397 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 405531003398 NADP binding site [chemical binding]; other site 405531003399 active site 405531003400 putative substrate binding site [chemical binding]; other site 405531003401 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 405531003402 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 405531003403 NAD binding site [chemical binding]; other site 405531003404 homotetramer interface [polypeptide binding]; other site 405531003405 homodimer interface [polypeptide binding]; other site 405531003406 substrate binding site [chemical binding]; other site 405531003407 active site 405531003408 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 405531003409 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405531003410 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 405531003411 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 405531003412 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405531003413 Part of AAA domain; Region: AAA_19; pfam13245 405531003414 Family description; Region: UvrD_C_2; pfam13538 405531003415 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531003416 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531003417 Coenzyme A binding pocket [chemical binding]; other site 405531003418 hypothetical protein; Provisional; Region: PRK13679 405531003419 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405531003420 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405531003421 Putative esterase; Region: Esterase; pfam00756 405531003422 EamA-like transporter family; Region: EamA; pfam00892 405531003423 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531003424 EamA-like transporter family; Region: EamA; pfam00892 405531003425 potential frameshift: common BLAST hit: gi|49184171|ref|YP_027423.1| lipoprotein 405531003426 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405531003427 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 405531003428 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405531003429 Na binding site [ion binding]; other site 405531003430 anthranilate synthase component I; Provisional; Region: PRK13570 405531003431 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405531003432 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405531003433 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405531003434 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405531003435 glutamine binding [chemical binding]; other site 405531003436 catalytic triad [active] 405531003437 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 405531003438 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405531003439 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405531003440 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 405531003441 active site 405531003442 ribulose/triose binding site [chemical binding]; other site 405531003443 phosphate binding site [ion binding]; other site 405531003444 substrate (anthranilate) binding pocket [chemical binding]; other site 405531003445 product (indole) binding pocket [chemical binding]; other site 405531003446 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 405531003447 active site 405531003448 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 405531003449 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 405531003450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531003451 catalytic residue [active] 405531003452 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 405531003453 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 405531003454 substrate binding site [chemical binding]; other site 405531003455 active site 405531003456 catalytic residues [active] 405531003457 heterodimer interface [polypeptide binding]; other site 405531003458 Protein of unknown function (DUF4029); Region: DUF4029; pfam13221 405531003459 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 405531003460 L-lactate permease; Region: Lactate_perm; cl00701 405531003461 Probable transposase; Region: OrfB_IS605; pfam01385 405531003462 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531003463 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405531003464 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405531003465 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 405531003466 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405531003467 Double zinc ribbon; Region: DZR; pfam12773 405531003468 Predicted membrane protein [Function unknown]; Region: COG4640 405531003469 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405531003470 YARHG domain; Region: YARHG; pfam13308 405531003471 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 405531003472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531003473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531003474 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405531003475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531003476 Coenzyme A binding pocket [chemical binding]; other site 405531003477 Protein of unknown function (DUF3908); Region: DUF3908; pfam13048 405531003478 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405531003479 NADPH bind site [chemical binding]; other site 405531003480 putative FMN binding site [chemical binding]; other site 405531003481 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405531003482 putative FMN binding site [chemical binding]; other site 405531003483 NADPH bind site [chemical binding]; other site 405531003484 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405531003485 YcaO-like family; Region: YcaO; pfam02624 405531003486 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 405531003487 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 405531003488 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 405531003489 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 405531003490 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405531003491 E3 interaction surface; other site 405531003492 lipoyl attachment site [posttranslational modification]; other site 405531003493 e3 binding domain; Region: E3_binding; pfam02817 405531003494 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405531003495 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 405531003496 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 405531003497 TPP-binding site [chemical binding]; other site 405531003498 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 405531003499 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531003500 salt bridge; other site 405531003501 non-specific DNA binding site [nucleotide binding]; other site 405531003502 sequence-specific DNA binding site [nucleotide binding]; other site 405531003503 Domain of unknown function (DUF3976); Region: DUF3976; pfam13121 405531003504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531003505 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405531003506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531003507 Walker A/P-loop; other site 405531003508 ATP binding site [chemical binding]; other site 405531003509 Q-loop/lid; other site 405531003510 ABC transporter signature motif; other site 405531003511 Walker B; other site 405531003512 D-loop; other site 405531003513 H-loop/switch region; other site 405531003514 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 405531003515 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405531003516 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405531003517 cxxc_20_cxxc protein; Region: cxxc_20_cxxc; TIGR04104 405531003518 Methyltransferase domain; Region: Methyltransf_11; pfam08241 405531003519 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405531003520 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531003521 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405531003522 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 405531003523 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531003524 Catalytic site [active] 405531003525 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405531003526 Domain of unknown function (DUF4047); Region: DUF4047; pfam13256 405531003527 Camelysin metallo-endopeptidase; Region: Peptidase_M73; pfam12389 405531003528 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531003529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531003530 non-specific DNA binding site [nucleotide binding]; other site 405531003531 salt bridge; other site 405531003532 sequence-specific DNA binding site [nucleotide binding]; other site 405531003533 Anti-repressor SinI; Region: SinI; pfam08671 405531003534 Anti-repressor SinI; Region: SinI; pfam08671 405531003535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405531003536 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405531003537 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 405531003538 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 405531003539 NAD(P) binding site [chemical binding]; other site 405531003540 catalytic residues [active] 405531003541 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405531003542 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 405531003543 Walker A/P-loop; other site 405531003544 ATP binding site [chemical binding]; other site 405531003545 Q-loop/lid; other site 405531003546 ABC transporter signature motif; other site 405531003547 Walker B; other site 405531003548 D-loop; other site 405531003549 H-loop/switch region; other site 405531003550 TOBE domain; Region: TOBE_2; pfam08402 405531003551 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405531003552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531003553 dimer interface [polypeptide binding]; other site 405531003554 conserved gate region; other site 405531003555 putative PBP binding loops; other site 405531003556 ABC-ATPase subunit interface; other site 405531003557 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405531003558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531003559 dimer interface [polypeptide binding]; other site 405531003560 conserved gate region; other site 405531003561 putative PBP binding loops; other site 405531003562 ABC-ATPase subunit interface; other site 405531003563 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 405531003564 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405531003565 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405531003566 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405531003567 active site 405531003568 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 405531003569 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 405531003570 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405531003571 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405531003572 active site 405531003573 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405531003574 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405531003575 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405531003576 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405531003577 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405531003578 Cysteine-rich domain; Region: CCG; pfam02754 405531003579 Cysteine-rich domain; Region: CCG; pfam02754 405531003580 FAD binding domain; Region: FAD_binding_4; pfam01565 405531003581 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 405531003582 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 405531003583 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 405531003584 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405531003585 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405531003586 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405531003587 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531003588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531003589 active site 405531003590 phosphorylation site [posttranslational modification] 405531003591 intermolecular recognition site; other site 405531003592 dimerization interface [polypeptide binding]; other site 405531003593 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531003594 DNA binding site [nucleotide binding] 405531003595 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405531003596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531003597 dimerization interface [polypeptide binding]; other site 405531003598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531003599 dimer interface [polypeptide binding]; other site 405531003600 phosphorylation site [posttranslational modification] 405531003601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531003602 ATP binding site [chemical binding]; other site 405531003603 Mg2+ binding site [ion binding]; other site 405531003604 G-X-G motif; other site 405531003605 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405531003606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531003607 DNA-binding site [nucleotide binding]; DNA binding site 405531003608 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405531003609 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 405531003610 Cysteine-rich domain; Region: CCG; pfam02754 405531003611 Cysteine-rich domain; Region: CCG; pfam02754 405531003612 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 405531003613 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 405531003614 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 405531003615 Uncharacterized conserved protein [Function unknown]; Region: COG1556 405531003616 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405531003617 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 405531003618 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 405531003619 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405531003620 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 405531003621 yybP-ykoY leader 405531003622 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405531003623 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405531003624 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531003625 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 405531003626 dimer interaction site [polypeptide binding]; other site 405531003627 substrate-binding tunnel; other site 405531003628 active site 405531003629 catalytic site [active] 405531003630 substrate binding site [chemical binding]; other site 405531003631 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820 405531003632 poly-beta-hydroxybutyrate-responsive repressor; Region: repress_PhaQ; TIGR02719 405531003633 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531003634 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 405531003635 acetoacetyl-CoA reductase; Provisional; Region: PRK12935 405531003636 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405531003637 NAD(P) binding site [chemical binding]; other site 405531003638 homotetramer interface [polypeptide binding]; other site 405531003639 homodimer interface [polypeptide binding]; other site 405531003640 active site 405531003641 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 405531003642 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 405531003643 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 405531003644 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 405531003645 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405531003646 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405531003647 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405531003648 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 405531003649 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405531003650 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 405531003651 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 405531003652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531003653 Walker A/P-loop; other site 405531003654 ATP binding site [chemical binding]; other site 405531003655 Q-loop/lid; other site 405531003656 ABC transporter signature motif; other site 405531003657 Walker B; other site 405531003658 D-loop; other site 405531003659 H-loop/switch region; other site 405531003660 TOBE domain; Region: TOBE_2; pfam08402 405531003661 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 405531003662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531003663 dimer interface [polypeptide binding]; other site 405531003664 conserved gate region; other site 405531003665 putative PBP binding loops; other site 405531003666 ABC-ATPase subunit interface; other site 405531003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531003668 dimer interface [polypeptide binding]; other site 405531003669 conserved gate region; other site 405531003670 putative PBP binding loops; other site 405531003671 ABC-ATPase subunit interface; other site 405531003672 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 405531003673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531003674 motif II; other site 405531003675 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 405531003676 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531003677 catalytic residue [active] 405531003678 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 405531003679 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405531003680 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405531003681 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405531003682 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531003683 heme-binding site [chemical binding]; other site 405531003684 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405531003685 Leucine rich repeat; Region: LRR_8; pfam13855 405531003686 Substrate binding site [chemical binding]; other site 405531003687 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 405531003688 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003689 Leucine-rich repeats; other site 405531003690 Substrate binding site [chemical binding]; other site 405531003691 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003692 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003693 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003694 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003695 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003696 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 405531003697 LRR adjacent; Region: LRR_adjacent; pfam08191 405531003698 S-layer homology domain; Region: SLH; pfam00395 405531003699 S-layer homology domain; Region: SLH; pfam00395 405531003700 S-layer homology domain; Region: SLH; pfam00395 405531003701 hypothetical protein; Validated; Region: PRK06755 405531003702 intersubunit interface [polypeptide binding]; other site 405531003703 active site 405531003704 Zn2+ binding site [ion binding]; other site 405531003705 FOG: CBS domain [General function prediction only]; Region: COG0517 405531003706 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405531003707 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 405531003708 NodB motif; other site 405531003709 putative active site [active] 405531003710 putative catalytic site [active] 405531003711 Zn binding site [ion binding]; other site 405531003712 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405531003713 Protein of unknown function (DUF3149); Region: DUF3149; pfam11346 405531003714 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531003715 dimer interface [polypeptide binding]; other site 405531003716 phosphorylation site [posttranslational modification] 405531003717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531003718 ATP binding site [chemical binding]; other site 405531003719 Mg2+ binding site [ion binding]; other site 405531003720 G-X-G motif; other site 405531003721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531003722 MarR family; Region: MarR; pfam01047 405531003723 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405531003724 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405531003725 active site 405531003726 Zn binding site [ion binding]; other site 405531003727 DinB superfamily; Region: DinB_2; pfam12867 405531003728 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405531003729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531003730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531003731 dimer interface [polypeptide binding]; other site 405531003732 phosphorylation site [posttranslational modification] 405531003733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531003734 ATP binding site [chemical binding]; other site 405531003735 Mg2+ binding site [ion binding]; other site 405531003736 G-X-G motif; other site 405531003737 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 405531003738 Ligand Binding Site [chemical binding]; other site 405531003739 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 405531003740 active site 405531003741 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 405531003742 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 405531003743 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 405531003744 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 405531003745 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 405531003746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531003747 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531003748 Coenzyme A binding pocket [chemical binding]; other site 405531003749 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 405531003750 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 405531003751 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 405531003752 Class I ribonucleotide reductase; Region: RNR_I; cd01679 405531003753 active site 405531003754 dimer interface [polypeptide binding]; other site 405531003755 catalytic residues [active] 405531003756 effector binding site; other site 405531003757 R2 peptide binding site; other site 405531003758 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 405531003759 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405531003760 dimer interface [polypeptide binding]; other site 405531003761 putative radical transfer pathway; other site 405531003762 diiron center [ion binding]; other site 405531003763 tyrosyl radical; other site 405531003764 Predicted transcriptional regulators [Transcription]; Region: COG1725 405531003765 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531003766 DNA-binding site [nucleotide binding]; DNA binding site 405531003767 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405531003768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531003769 Walker A/P-loop; other site 405531003770 ATP binding site [chemical binding]; other site 405531003771 Q-loop/lid; other site 405531003772 ABC transporter signature motif; other site 405531003773 Walker B; other site 405531003774 D-loop; other site 405531003775 H-loop/switch region; other site 405531003776 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531003777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531003778 Walker A/P-loop; other site 405531003779 ATP binding site [chemical binding]; other site 405531003780 Q-loop/lid; other site 405531003781 ABC transporter signature motif; other site 405531003782 Walker B; other site 405531003783 D-loop; other site 405531003784 H-loop/switch region; other site 405531003785 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405531003786 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405531003787 CAAX protease self-immunity; Region: Abi; pfam02517 405531003788 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405531003789 Protein of unknown function (DUF3913); Region: DUF3913; pfam13052 405531003790 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405531003791 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531003792 putative DNA binding site [nucleotide binding]; other site 405531003793 putative Zn2+ binding site [ion binding]; other site 405531003794 AsnC family; Region: AsnC_trans_reg; pfam01037 405531003795 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405531003796 Isochorismatase family; Region: Isochorismatase; pfam00857 405531003797 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405531003798 catalytic triad [active] 405531003799 conserved cis-peptide bond; other site 405531003800 SseB protein; Region: SseB; cl06279 405531003801 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 405531003802 dimer interface [polypeptide binding]; other site 405531003803 catalytic triad [active] 405531003804 Nitronate monooxygenase; Region: NMO; pfam03060 405531003805 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 405531003806 FMN binding site [chemical binding]; other site 405531003807 substrate binding site [chemical binding]; other site 405531003808 putative catalytic residue [active] 405531003809 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405531003810 DltD N-terminal region; Region: DltD_N; pfam04915 405531003811 DltD central region; Region: DltD_M; pfam04918 405531003812 DltD C-terminal region; Region: DltD_C; pfam04914 405531003813 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 405531003814 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 405531003815 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 405531003816 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 405531003817 acyl-activating enzyme (AAE) consensus motif; other site 405531003818 AMP binding site [chemical binding]; other site 405531003819 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 405531003820 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405531003821 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 405531003822 metal binding site [ion binding]; metal-binding site 405531003823 dimer interface [polypeptide binding]; other site 405531003824 flavodoxin; Provisional; Region: PRK06756 405531003825 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 405531003826 Phosphotransferase enzyme family; Region: APH; pfam01636 405531003827 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531003828 active site 405531003829 substrate binding site [chemical binding]; other site 405531003830 ATP binding site [chemical binding]; other site 405531003831 multidrug efflux protein; Reviewed; Region: PRK01766 405531003832 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 405531003833 cation binding site [ion binding]; other site 405531003834 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405531003835 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531003836 catalytic residues [active] 405531003837 Regulatory protein YrvL; Region: YrvL; pfam14184 405531003838 Regulatory protein YrvL; Region: YrvL; pfam14184 405531003839 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531003840 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405531003841 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405531003842 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405531003843 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405531003844 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 405531003845 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405531003846 hypothetical protein; Provisional; Region: PRK03094 405531003847 Protein of unknown function (DUF3911); Region: DUF3911; pfam13050 405531003848 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405531003849 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405531003850 homodimer interface [polypeptide binding]; other site 405531003851 substrate-cofactor binding pocket; other site 405531003852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531003853 catalytic residue [active] 405531003854 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 405531003855 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405531003856 PYR/PP interface [polypeptide binding]; other site 405531003857 dimer interface [polypeptide binding]; other site 405531003858 TPP binding site [chemical binding]; other site 405531003859 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405531003860 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405531003861 TPP-binding site [chemical binding]; other site 405531003862 dimer interface [polypeptide binding]; other site 405531003863 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 405531003864 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405531003865 putative valine binding site [chemical binding]; other site 405531003866 dimer interface [polypeptide binding]; other site 405531003867 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 405531003868 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405531003869 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405531003870 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405531003871 2-isopropylmalate synthase; Validated; Region: PRK00915 405531003872 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 405531003873 active site 405531003874 catalytic residues [active] 405531003875 metal binding site [ion binding]; metal-binding site 405531003876 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 405531003877 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 405531003878 tartrate dehydrogenase; Region: TTC; TIGR02089 405531003879 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 405531003880 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 405531003881 substrate binding site [chemical binding]; other site 405531003882 ligand binding site [chemical binding]; other site 405531003883 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 405531003884 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 405531003885 substrate binding site [chemical binding]; other site 405531003886 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 405531003887 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405531003888 dimer interface [polypeptide binding]; other site 405531003889 motif 1; other site 405531003890 active site 405531003891 motif 2; other site 405531003892 motif 3; other site 405531003893 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 405531003894 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 405531003895 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 405531003896 histidinol dehydrogenase; Region: hisD; TIGR00069 405531003897 NAD binding site [chemical binding]; other site 405531003898 dimerization interface [polypeptide binding]; other site 405531003899 product binding site; other site 405531003900 substrate binding site [chemical binding]; other site 405531003901 zinc binding site [ion binding]; other site 405531003902 catalytic residues [active] 405531003903 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 405531003904 putative active site pocket [active] 405531003905 4-fold oligomerization interface [polypeptide binding]; other site 405531003906 metal binding residues [ion binding]; metal-binding site 405531003907 3-fold/trimer interface [polypeptide binding]; other site 405531003908 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 405531003909 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 405531003910 putative active site [active] 405531003911 oxyanion strand; other site 405531003912 catalytic triad [active] 405531003913 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 405531003914 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 405531003915 catalytic residues [active] 405531003916 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 405531003917 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 405531003918 substrate binding site [chemical binding]; other site 405531003919 glutamase interaction surface [polypeptide binding]; other site 405531003920 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 405531003921 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 405531003922 metal binding site [ion binding]; metal-binding site 405531003923 histidinol-phosphatase; Validated; Region: PRK06740 405531003924 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 405531003925 dimer interface [polypeptide binding]; other site 405531003926 active site 405531003927 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_13; cd12178 405531003928 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 405531003929 putative ligand binding site [chemical binding]; other site 405531003930 putative NAD binding site [chemical binding]; other site 405531003931 catalytic site [active] 405531003932 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 405531003933 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 405531003934 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405531003935 Sulfatase; Region: Sulfatase; pfam00884 405531003936 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405531003937 Lysine riboswitch 405531003938 diaminopimelate decarboxylase; Region: lysA; TIGR01048 405531003939 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 405531003940 active site 405531003941 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405531003942 substrate binding site [chemical binding]; other site 405531003943 catalytic residues [active] 405531003944 dimer interface [polypeptide binding]; other site 405531003945 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 405531003946 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 405531003947 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405531003948 Active Sites [active] 405531003949 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 405531003950 ATP-sulfurylase; Region: ATPS; cd00517 405531003951 active site 405531003952 HXXH motif; other site 405531003953 flexible loop; other site 405531003954 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 405531003955 ligand-binding site [chemical binding]; other site 405531003956 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 405531003957 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405531003958 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405531003959 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 405531003960 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405531003961 diphthine synthase; Region: dph5; TIGR00522 405531003962 active site 405531003963 SAM binding site [chemical binding]; other site 405531003964 homodimer interface [polypeptide binding]; other site 405531003965 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405531003966 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405531003967 putative active site [active] 405531003968 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405531003969 putative active site [active] 405531003970 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 405531003971 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 405531003972 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405531003973 Na2 binding site [ion binding]; other site 405531003974 putative substrate binding site 1 [chemical binding]; other site 405531003975 Na binding site 1 [ion binding]; other site 405531003976 putative substrate binding site 2 [chemical binding]; other site 405531003977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405531003978 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531003979 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531003980 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405531003981 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405531003982 Protein of unknown function (DUF402); Region: DUF402; cl00979 405531003983 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 405531003984 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405531003985 Vpu protein; Region: Vpu; pfam00558 405531003986 PspA/IM30 family; Region: PspA_IM30; pfam04012 405531003987 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 405531003988 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531003989 Histidine kinase; Region: HisKA_3; pfam07730 405531003990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531003991 ATP binding site [chemical binding]; other site 405531003992 Mg2+ binding site [ion binding]; other site 405531003993 G-X-G motif; other site 405531003994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531003995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531003996 active site 405531003997 phosphorylation site [posttranslational modification] 405531003998 intermolecular recognition site; other site 405531003999 dimerization interface [polypeptide binding]; other site 405531004000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531004001 DNA binding residues [nucleotide binding] 405531004002 dimerization interface [polypeptide binding]; other site 405531004003 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405531004004 E3 interaction surface; other site 405531004005 lipoyl attachment site [posttranslational modification]; other site 405531004006 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405531004007 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405531004008 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531004009 S-adenosylmethionine binding site [chemical binding]; other site 405531004010 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 405531004011 Peptidase family M50; Region: Peptidase_M50; pfam02163 405531004012 active site 405531004013 putative substrate binding region [chemical binding]; other site 405531004014 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 405531004015 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 405531004016 heme-binding site [chemical binding]; other site 405531004017 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 405531004018 FAD binding pocket [chemical binding]; other site 405531004019 FAD binding motif [chemical binding]; other site 405531004020 phosphate binding motif [ion binding]; other site 405531004021 beta-alpha-beta structure motif; other site 405531004022 NAD binding pocket [chemical binding]; other site 405531004023 Heme binding pocket [chemical binding]; other site 405531004024 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405531004025 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405531004026 ligand binding site [chemical binding]; other site 405531004027 flexible hinge region; other site 405531004028 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405531004029 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531004030 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405531004031 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 405531004032 Transglycosylase; Region: Transgly; pfam00912 405531004033 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405531004034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531004035 Protein of unknown function (DUF3982); Region: DUF3982; pfam13138 405531004036 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 405531004037 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 405531004038 putative active site [active] 405531004039 heme pocket [chemical binding]; other site 405531004040 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531004041 dimer interface [polypeptide binding]; other site 405531004042 phosphorylation site [posttranslational modification] 405531004043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531004044 ATP binding site [chemical binding]; other site 405531004045 Mg2+ binding site [ion binding]; other site 405531004046 G-X-G motif; other site 405531004047 Protein of unknown function DUF72; Region: DUF72; pfam01904 405531004048 Protein of unknown function (DUF3924); Region: DUF3924; pfam13062 405531004049 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405531004050 active site 405531004051 DNA binding site [nucleotide binding] 405531004052 Int/Topo IB signature motif; other site 405531004053 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531004054 dimerization interface [polypeptide binding]; other site 405531004055 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531004056 dimer interface [polypeptide binding]; other site 405531004057 phosphorylation site [posttranslational modification] 405531004058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531004059 ATP binding site [chemical binding]; other site 405531004060 Mg2+ binding site [ion binding]; other site 405531004061 G-X-G motif; other site 405531004062 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 405531004063 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 405531004064 Predicted integral membrane protein [Function unknown]; Region: COG0392 405531004065 Uncharacterized conserved protein [Function unknown]; Region: COG2898 405531004066 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 405531004067 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 405531004068 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405531004069 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405531004070 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405531004071 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405531004072 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531004073 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405531004074 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 405531004075 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 405531004076 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405531004077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531004078 RNA binding surface [nucleotide binding]; other site 405531004079 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 405531004080 active site 405531004081 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405531004082 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405531004083 catalytic residues [active] 405531004084 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 405531004085 ResB-like family; Region: ResB; pfam05140 405531004086 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405531004087 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 405531004088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531004089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531004090 active site 405531004091 phosphorylation site [posttranslational modification] 405531004092 intermolecular recognition site; other site 405531004093 dimerization interface [polypeptide binding]; other site 405531004094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531004095 DNA binding site [nucleotide binding] 405531004096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405531004097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531004098 dimerization interface [polypeptide binding]; other site 405531004099 PAS domain; Region: PAS; smart00091 405531004100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531004101 dimer interface [polypeptide binding]; other site 405531004102 phosphorylation site [posttranslational modification] 405531004103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531004104 ATP binding site [chemical binding]; other site 405531004105 Mg2+ binding site [ion binding]; other site 405531004106 G-X-G motif; other site 405531004107 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 405531004108 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531004109 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531004110 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 405531004111 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531004112 Predicted membrane protein [Function unknown]; Region: COG3601 405531004113 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 405531004114 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 405531004115 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 405531004116 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405531004117 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531004118 ATP binding site [chemical binding]; other site 405531004119 putative Mg++ binding site [ion binding]; other site 405531004120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531004121 nucleotide binding region [chemical binding]; other site 405531004122 ATP-binding site [chemical binding]; other site 405531004123 CAAX protease self-immunity; Region: Abi; pfam02517 405531004124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531004125 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405531004126 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531004127 putative active site [active] 405531004128 putative metal binding site [ion binding]; other site 405531004129 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531004130 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 405531004131 DNA binding residues [nucleotide binding] 405531004132 B12 binding domain; Region: B12-binding_2; pfam02607 405531004133 adaptor protein; Provisional; Region: PRK02899 405531004134 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405531004135 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405531004136 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 405531004137 NAD(P) binding site [chemical binding]; other site 405531004138 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 405531004139 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531004140 amidase catalytic site [active] 405531004141 Zn binding residues [ion binding]; other site 405531004142 substrate binding site [chemical binding]; other site 405531004143 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 405531004144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405531004145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531004146 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 405531004147 active site 405531004148 homodimer interface [polypeptide binding]; other site 405531004149 homotetramer interface [polypeptide binding]; other site 405531004150 cytidylate kinase; Provisional; Region: cmk; PRK00023 405531004151 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 405531004152 CMP-binding site; other site 405531004153 The sites determining sugar specificity; other site 405531004154 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 405531004155 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 405531004156 RNA binding site [nucleotide binding]; other site 405531004157 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 405531004158 RNA binding site [nucleotide binding]; other site 405531004159 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 405531004160 RNA binding site [nucleotide binding]; other site 405531004161 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 405531004162 RNA binding site [nucleotide binding]; other site 405531004163 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 405531004164 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 405531004165 homotetramer interface [polypeptide binding]; other site 405531004166 FMN binding site [chemical binding]; other site 405531004167 homodimer contacts [polypeptide binding]; other site 405531004168 putative active site [active] 405531004169 putative substrate binding site [chemical binding]; other site 405531004170 YpzI-like protein; Region: YpzI; pfam14140 405531004171 YIEGIA protein; Region: YIEGIA; pfam14045 405531004172 GTP-binding protein Der; Reviewed; Region: PRK00093 405531004173 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 405531004174 G1 box; other site 405531004175 GTP/Mg2+ binding site [chemical binding]; other site 405531004176 Switch I region; other site 405531004177 G2 box; other site 405531004178 Switch II region; other site 405531004179 G3 box; other site 405531004180 G4 box; other site 405531004181 G5 box; other site 405531004182 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 405531004183 G1 box; other site 405531004184 GTP/Mg2+ binding site [chemical binding]; other site 405531004185 Switch I region; other site 405531004186 G2 box; other site 405531004187 G3 box; other site 405531004188 Switch II region; other site 405531004189 G4 box; other site 405531004190 G5 box; other site 405531004191 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 405531004192 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405531004193 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 405531004194 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 405531004195 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 405531004196 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 405531004197 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 405531004198 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405531004199 IHF dimer interface [polypeptide binding]; other site 405531004200 IHF - DNA interface [nucleotide binding]; other site 405531004201 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 405531004202 homodecamer interface [polypeptide binding]; other site 405531004203 GTP cyclohydrolase I; Provisional; Region: PLN03044 405531004204 active site 405531004205 putative catalytic site residues [active] 405531004206 zinc binding site [ion binding]; other site 405531004207 GTP-CH-I/GFRP interaction surface; other site 405531004208 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 405531004209 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 405531004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531004211 S-adenosylmethionine binding site [chemical binding]; other site 405531004212 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405531004213 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405531004214 substrate binding pocket [chemical binding]; other site 405531004215 chain length determination region; other site 405531004216 substrate-Mg2+ binding site; other site 405531004217 catalytic residues [active] 405531004218 aspartate-rich region 1; other site 405531004219 active site lid residues [active] 405531004220 aspartate-rich region 2; other site 405531004221 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 405531004222 active site 405531004223 multimer interface [polypeptide binding]; other site 405531004224 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405531004225 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405531004226 Tetramer interface [polypeptide binding]; other site 405531004227 active site 405531004228 FMN-binding site [chemical binding]; other site 405531004229 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 405531004230 active site 405531004231 dimer interface [polypeptide binding]; other site 405531004232 metal binding site [ion binding]; metal-binding site 405531004233 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405531004234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531004235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531004236 homodimer interface [polypeptide binding]; other site 405531004237 catalytic residue [active] 405531004238 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531004239 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531004240 binding surface 405531004241 TPR motif; other site 405531004242 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 405531004243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531004244 binding surface 405531004245 TPR motif; other site 405531004246 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531004247 binding surface 405531004248 TPR motif; other site 405531004249 hypothetical protein; Provisional; Region: PRK03636 405531004250 UPF0302 domain; Region: UPF0302; pfam08864 405531004251 IDEAL domain; Region: IDEAL; pfam08858 405531004252 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 405531004253 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 405531004254 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 405531004255 iron-sulfur cluster [ion binding]; other site 405531004256 [2Fe-2S] cluster binding site [ion binding]; other site 405531004257 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405531004258 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 405531004259 interchain domain interface [polypeptide binding]; other site 405531004260 intrachain domain interface; other site 405531004261 heme bH binding site [chemical binding]; other site 405531004262 Qi binding site; other site 405531004263 heme bL binding site [chemical binding]; other site 405531004264 Qo binding site; other site 405531004265 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 405531004266 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 405531004267 interchain domain interface [polypeptide binding]; other site 405531004268 intrachain domain interface; other site 405531004269 Qi binding site; other site 405531004270 Qo binding site; other site 405531004271 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405531004272 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405531004273 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 405531004274 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 405531004275 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; pfam09577 405531004276 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 405531004277 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 405531004278 active site 405531004279 Fe-S cluster binding site [ion binding]; other site 405531004280 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531004281 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531004282 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531004283 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531004284 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 405531004285 homodimer interface [polypeptide binding]; other site 405531004286 metal binding site [ion binding]; metal-binding site 405531004287 dihydrodipicolinate reductase; Provisional; Region: PRK00048 405531004288 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 405531004289 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 405531004290 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 405531004291 active site 405531004292 dimer interfaces [polypeptide binding]; other site 405531004293 catalytic residues [active] 405531004294 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 405531004295 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 405531004296 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 405531004297 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 405531004298 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405531004299 active site 405531004300 NTP binding site [chemical binding]; other site 405531004301 metal binding triad [ion binding]; metal-binding site 405531004302 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405531004303 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 405531004304 Biotin operon repressor [Transcription]; Region: BirA; COG1654 405531004305 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 405531004306 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 405531004307 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 405531004308 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405531004309 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 405531004310 oligomerization interface [polypeptide binding]; other site 405531004311 active site 405531004312 metal binding site [ion binding]; metal-binding site 405531004313 pantoate--beta-alanine ligase; Region: panC; TIGR00018 405531004314 Pantoate-beta-alanine ligase; Region: PanC; cd00560 405531004315 active site 405531004316 ATP-binding site [chemical binding]; other site 405531004317 pantoate-binding site; other site 405531004318 HXXH motif; other site 405531004319 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 405531004320 tetramerization interface [polypeptide binding]; other site 405531004321 active site 405531004322 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 405531004323 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405531004324 active site 405531004325 catalytic site [active] 405531004326 substrate binding site [chemical binding]; other site 405531004327 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405531004328 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405531004329 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 405531004330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 405531004331 aspartate aminotransferase; Provisional; Region: PRK05764 405531004332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531004333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531004334 homodimer interface [polypeptide binding]; other site 405531004335 catalytic residue [active] 405531004336 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 405531004337 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 405531004338 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405531004339 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 405531004340 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405531004341 minor groove reading motif; other site 405531004342 helix-hairpin-helix signature motif; other site 405531004343 substrate binding pocket [chemical binding]; other site 405531004344 active site 405531004345 Transglycosylase; Region: Transgly; pfam00912 405531004346 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405531004347 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531004348 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 405531004349 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405531004350 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 405531004351 YppF-like protein; Region: YppF; pfam14178 405531004352 YppG-like protein; Region: YppG; pfam14179 405531004353 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 405531004354 hypothetical protein; Provisional; Region: PRK13660 405531004355 cell division protein GpsB; Provisional; Region: PRK14127 405531004356 DivIVA domain; Region: DivI1A_domain; TIGR03544 405531004357 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 405531004358 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 405531004359 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 405531004360 Protein of unknown function (DUF3921); Region: DUF3921; pfam13060 405531004361 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 405531004362 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 405531004363 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405531004364 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 405531004365 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 405531004366 active site 405531004367 Zn binding site [ion binding]; other site 405531004368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531004369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531004370 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 405531004371 Phosphotransferase enzyme family; Region: APH; pfam01636 405531004372 putative active site [active] 405531004373 putative substrate binding site [chemical binding]; other site 405531004374 ATP binding site [chemical binding]; other site 405531004375 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405531004376 active site 405531004377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531004378 active site 405531004379 xanthine permease; Region: pbuX; TIGR03173 405531004380 Predicted membrane protein [Function unknown]; Region: COG2311 405531004381 Protein of unknown function (DUF418); Region: DUF418; cl12135 405531004382 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405531004383 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405531004384 Dynamin family; Region: Dynamin_N; pfam00350 405531004385 G1 box; other site 405531004386 GTP/Mg2+ binding site [chemical binding]; other site 405531004387 G2 box; other site 405531004388 Switch I region; other site 405531004389 G3 box; other site 405531004390 Switch II region; other site 405531004391 G4 box; other site 405531004392 G5 box; other site 405531004393 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405531004394 Dynamin family; Region: Dynamin_N; pfam00350 405531004395 G1 box; other site 405531004396 GTP/Mg2+ binding site [chemical binding]; other site 405531004397 G2 box; other site 405531004398 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 405531004399 G3 box; other site 405531004400 Switch II region; other site 405531004401 GTP/Mg2+ binding site [chemical binding]; other site 405531004402 G4 box; other site 405531004403 G5 box; other site 405531004404 Protein of unknown function (DUF3931); Region: DUF3931; pfam13082 405531004405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531004406 Coenzyme A binding pocket [chemical binding]; other site 405531004407 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 405531004408 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 405531004409 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 405531004410 active site residue [active] 405531004411 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 405531004412 active site residue [active] 405531004413 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405531004414 Predicted membrane protein [Function unknown]; Region: COG3766 405531004415 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405531004416 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405531004417 ykoK leader 405531004418 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405531004419 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531004420 5'-3' exonuclease; Region: 53EXOc; smart00475 405531004421 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405531004422 active site 405531004423 metal binding site 1 [ion binding]; metal-binding site 405531004424 putative 5' ssDNA interaction site; other site 405531004425 metal binding site 3; metal-binding site 405531004426 metal binding site 2 [ion binding]; metal-binding site 405531004427 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405531004428 putative DNA binding site [nucleotide binding]; other site 405531004429 putative metal binding site [ion binding]; other site 405531004430 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405531004431 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 405531004432 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405531004433 Chain length determinant protein; Region: Wzz; cl15801 405531004434 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405531004435 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405531004436 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405531004437 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405531004438 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405531004439 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 405531004440 O-Antigen ligase; Region: Wzy_C; pfam04932 405531004441 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405531004442 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405531004443 active site 405531004444 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405531004445 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405531004446 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 405531004447 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004448 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004449 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004450 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004451 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004452 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004453 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004454 Domain of unknown function DUF11; Region: DUF11; cl17728 405531004455 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004456 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004457 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004458 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004459 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004460 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004461 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004462 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004463 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004464 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004465 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004466 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004467 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004468 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004469 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004470 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004471 Domain of unknown function DUF11; Region: DUF11; cl17728 405531004472 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004473 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004474 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531004475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531004476 Coenzyme A binding pocket [chemical binding]; other site 405531004477 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405531004478 Isochorismatase family; Region: Isochorismatase; pfam00857 405531004479 catalytic triad [active] 405531004480 conserved cis-peptide bond; other site 405531004481 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531004482 EamA-like transporter family; Region: EamA; pfam00892 405531004483 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405531004484 RNA/DNA hybrid binding site [nucleotide binding]; other site 405531004485 active site 405531004486 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 405531004487 active site 405531004488 catalytic residues [active] 405531004489 QueT transporter; Region: QueT; pfam06177 405531004490 hypothetical protein; Validated; Region: PRK07708 405531004491 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 405531004492 RNA/DNA hybrid binding site [nucleotide binding]; other site 405531004493 active site 405531004494 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 405531004495 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 405531004496 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531004497 DNA-binding site [nucleotide binding]; DNA binding site 405531004498 RNA-binding motif; other site 405531004499 YqcI/YcgG family; Region: YqcI_YcgG; pfam08892 405531004500 LysE type translocator; Region: LysE; pfam01810 405531004501 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 405531004502 Protein of unknown function, DUF485; Region: DUF485; pfam04341 405531004503 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405531004504 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 405531004505 Na binding site [ion binding]; other site 405531004506 aminotransferase; Validated; Region: PRK07678 405531004507 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531004508 inhibitor-cofactor binding pocket; inhibition site 405531004509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531004510 catalytic residue [active] 405531004511 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405531004512 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405531004513 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405531004514 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405531004515 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531004516 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405531004517 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531004518 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405531004519 DNA binding residues [nucleotide binding] 405531004520 drug binding residues [chemical binding]; other site 405531004521 dimer interface [polypeptide binding]; other site 405531004522 Transcriptional regulator, effector-binding domain/component [Transcription / Signal transduction mechanisms]; Region: COG4978 405531004523 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 405531004524 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 405531004525 Predicted membrane protein [Function unknown]; Region: COG2323 405531004526 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405531004527 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405531004528 putative active site [active] 405531004529 Tic20-like protein; Region: Tic20; pfam09685 405531004530 putative transposase OrfB; Reviewed; Region: PHA02517 405531004531 HTH-like domain; Region: HTH_21; pfam13276 405531004532 Integrase core domain; Region: rve; pfam00665 405531004533 Integrase core domain; Region: rve_2; pfam13333 405531004534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405531004535 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531004536 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531004537 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 405531004538 dimer interface [polypeptide binding]; other site 405531004539 FMN binding site [chemical binding]; other site 405531004540 NADPH bind site [chemical binding]; other site 405531004541 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405531004542 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531004543 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405531004544 bacterial Hfq-like; Region: Hfq; cd01716 405531004545 hexamer interface [polypeptide binding]; other site 405531004546 Sm1 motif; other site 405531004547 RNA binding site [nucleotide binding]; other site 405531004548 Sm2 motif; other site 405531004549 HD domain; Region: HD_3; pfam13023 405531004550 flagellar motor protein MotP; Reviewed; Region: PRK06743 405531004551 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405531004552 flagellar motor protein MotS; Reviewed; Region: PRK06742 405531004553 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405531004554 ligand binding site [chemical binding]; other site 405531004555 Response regulator receiver domain; Region: Response_reg; pfam00072 405531004556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531004557 active site 405531004558 phosphorylation site [posttranslational modification] 405531004559 intermolecular recognition site; other site 405531004560 dimerization interface [polypeptide binding]; other site 405531004561 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 405531004562 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405531004563 putative binding surface; other site 405531004564 active site 405531004565 P2 response regulator binding domain; Region: P2; pfam07194 405531004566 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 405531004567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531004568 ATP binding site [chemical binding]; other site 405531004569 Mg2+ binding site [ion binding]; other site 405531004570 G-X-G motif; other site 405531004571 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 405531004572 flagellar motor switch protein; Reviewed; Region: PRK06782 405531004573 CheC-like family; Region: CheC; pfam04509 405531004574 CheC-like family; Region: CheC; pfam04509 405531004575 CheC-like family; Region: CheC; pfam04509 405531004576 CheC-like family; Region: CheC; pfam04509 405531004577 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405531004578 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 405531004579 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405531004580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531004581 Protein of unknown function (DUF327); Region: DUF327; pfam03885 405531004582 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK06799 405531004583 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK08073 405531004584 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405531004585 flagellar capping protein; Validated; Region: fliD; PRK06798 405531004586 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 405531004587 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 405531004588 Flagellar protein FliS; Region: FliS; cl00654 405531004589 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK06797 405531004590 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 405531004591 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 405531004592 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405531004593 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK01699 405531004594 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 405531004595 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 405531004596 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 405531004597 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 405531004598 FliG C-terminal domain; Region: FliG_C; pfam01706 405531004599 flagellar assembly protein H; Validated; Region: fliH; PRK06800 405531004600 Flagellar assembly protein FliH; Region: FliH; pfam02108 405531004601 flagellum-specific ATP synthase; Validated; Region: fliI; PRK06793 405531004602 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405531004603 Walker A motif; other site 405531004604 ATP binding site [chemical binding]; other site 405531004605 Walker B motif; other site 405531004606 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 405531004607 flagellar basal body rod modification protein; Validated; Region: flgD; PRK06792 405531004608 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 405531004609 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 405531004610 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405531004611 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 405531004612 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405531004613 Protein of unknown function (DUF3964); Region: DUF3964; pfam13107 405531004614 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 405531004615 Response regulator receiver domain; Region: Response_reg; pfam00072 405531004616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531004617 active site 405531004618 phosphorylation site [posttranslational modification] 405531004619 intermolecular recognition site; other site 405531004620 dimerization interface [polypeptide binding]; other site 405531004621 DNA binding domain of the motility gene repressor (MogR); Region: MogR_DNAbind; pfam12181 405531004622 putative transposase OrfB; Reviewed; Region: PHA02517 405531004623 HTH-like domain; Region: HTH_21; pfam13276 405531004624 Integrase core domain; Region: rve; pfam00665 405531004625 Integrase core domain; Region: rve_2; pfam13333 405531004626 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405531004627 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531004628 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531004629 Winged helix-turn helix; Region: HTH_29; pfam13551 405531004630 flagellin; Provisional; Region: PRK12807 405531004631 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405531004632 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405531004633 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 405531004634 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405531004635 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405531004636 catalytic residue [active] 405531004637 flagellar motor switch protein; Validated; Region: PRK06789 405531004638 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 405531004639 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405531004640 flagellar motor switch protein; Validated; Region: PRK06788 405531004641 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 405531004642 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 405531004643 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 405531004644 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 405531004645 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 405531004646 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 405531004647 FHIPEP family; Region: FHIPEP; pfam00771 405531004648 flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK11889 405531004649 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405531004650 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12819 405531004651 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 405531004652 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 405531004653 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 405531004654 active site 405531004655 non-prolyl cis peptide bond; other site 405531004656 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405531004657 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 405531004658 Predicted transcriptional regulators [Transcription]; Region: COG1378 405531004659 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405531004660 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405531004661 C-terminal domain interface [polypeptide binding]; other site 405531004662 sugar binding site [chemical binding]; other site 405531004663 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 405531004664 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 405531004665 Protein of unknown function (DUF3951); Region: DUF3951; pfam13131 405531004666 Dienelactone hydrolase family; Region: DLH; pfam01738 405531004667 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405531004668 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 405531004669 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405531004670 DXD motif; other site 405531004671 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531004672 PilZ domain; Region: PilZ; pfam07238 405531004673 PilZ domain; Region: PilZ; pfam07238 405531004674 small acid-soluble spore protein, H-type; Region: SASP_H; TIGR02861 405531004675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531004676 non-specific DNA binding site [nucleotide binding]; other site 405531004677 salt bridge; other site 405531004678 sequence-specific DNA binding site [nucleotide binding]; other site 405531004679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531004680 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531004681 putative substrate translocation pore; other site 405531004682 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 405531004683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531004684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531004685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531004686 dimerization interface [polypeptide binding]; other site 405531004687 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405531004688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531004689 Walker A/P-loop; other site 405531004690 ATP binding site [chemical binding]; other site 405531004691 Q-loop/lid; other site 405531004692 ABC transporter signature motif; other site 405531004693 Walker B; other site 405531004694 D-loop; other site 405531004695 H-loop/switch region; other site 405531004696 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 405531004697 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 405531004698 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405531004699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531004700 dimer interface [polypeptide binding]; other site 405531004701 conserved gate region; other site 405531004702 putative PBP binding loops; other site 405531004703 ABC-ATPase subunit interface; other site 405531004704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531004705 dimer interface [polypeptide binding]; other site 405531004706 conserved gate region; other site 405531004707 putative PBP binding loops; other site 405531004708 ABC-ATPase subunit interface; other site 405531004709 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 405531004710 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 405531004711 Beta-Casp domain; Region: Beta-Casp; smart01027 405531004712 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405531004713 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405531004714 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531004715 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405531004716 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531004717 catalytic core [active] 405531004718 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 405531004719 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531004720 hypothetical protein; Provisional; Region: PRK09272 405531004721 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531004722 MarR family; Region: MarR_2; pfam12802 405531004723 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 405531004724 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405531004725 active site 405531004726 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 405531004727 dimer interface [polypeptide binding]; other site 405531004728 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405531004729 Ligand Binding Site [chemical binding]; other site 405531004730 Molecular Tunnel; other site 405531004731 RNA polymerase factor sigma-70; Validated; Region: PRK06811 405531004732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531004733 DNA binding residues [nucleotide binding] 405531004734 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405531004735 VPS10 domain; Region: VPS10; smart00602 405531004736 VPS10 domain; Region: VPS10; smart00602 405531004737 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 405531004738 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405531004739 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 405531004740 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405531004741 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405531004742 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 405531004743 Predicted permeases [General function prediction only]; Region: COG0701 405531004744 TIGR03943 family protein; Region: TIGR03943 405531004745 Methyltransferase domain; Region: Methyltransf_24; pfam13578 405531004746 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405531004747 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531004748 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405531004749 DNA binding residues [nucleotide binding] 405531004750 putative dimer interface [polypeptide binding]; other site 405531004751 short chain dehydrogenase; Provisional; Region: PRK06123 405531004752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531004753 NAD(P) binding site [chemical binding]; other site 405531004754 active site 405531004755 fumarate hydratase; Reviewed; Region: fumC; PRK00485 405531004756 Class II fumarases; Region: Fumarase_classII; cd01362 405531004757 active site 405531004758 tetramer interface [polypeptide binding]; other site 405531004759 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405531004760 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 405531004761 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 405531004762 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 405531004763 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 405531004764 active site pocket [active] 405531004765 oxyanion hole [active] 405531004766 catalytic triad [active] 405531004767 active site nucleophile [active] 405531004768 Protein of unknown function (DUF3942); Region: DUF3942; pfam13078 405531004769 Penicillinase repressor; Region: Pencillinase_R; pfam03965 405531004770 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 405531004771 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405531004772 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405531004773 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405531004774 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405531004775 catalytic residues [active] 405531004776 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 405531004777 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531004778 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 405531004779 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405531004780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531004781 non-specific DNA binding site [nucleotide binding]; other site 405531004782 salt bridge; other site 405531004783 sequence-specific DNA binding site [nucleotide binding]; other site 405531004784 Cupin domain; Region: Cupin_2; pfam07883 405531004785 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 405531004786 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 405531004787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531004788 catalytic residue [active] 405531004789 Protein of unknown function (DUF445); Region: DUF445; pfam04286 405531004790 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 405531004791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531004792 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531004793 DNA binding residues [nucleotide binding] 405531004794 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531004795 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531004796 active site 405531004797 phosphorylation site [posttranslational modification] 405531004798 intermolecular recognition site; other site 405531004799 dimerization interface [polypeptide binding]; other site 405531004800 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531004801 DNA binding residues [nucleotide binding] 405531004802 dimerization interface [polypeptide binding]; other site 405531004803 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531004804 Histidine kinase; Region: HisKA_3; pfam07730 405531004805 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531004806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531004807 Walker A/P-loop; other site 405531004808 ATP binding site [chemical binding]; other site 405531004809 Q-loop/lid; other site 405531004810 ABC transporter signature motif; other site 405531004811 Walker B; other site 405531004812 D-loop; other site 405531004813 H-loop/switch region; other site 405531004814 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405531004815 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405531004816 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405531004817 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405531004818 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405531004819 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405531004820 PLD-like domain; Region: PLDc_2; pfam13091 405531004821 putative active site [active] 405531004822 catalytic site [active] 405531004823 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405531004824 PLD-like domain; Region: PLDc_2; pfam13091 405531004825 putative active site [active] 405531004826 catalytic site [active] 405531004827 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405531004828 putative nucleotide binding site [chemical binding]; other site 405531004829 uridine monophosphate binding site [chemical binding]; other site 405531004830 homohexameric interface [polypeptide binding]; other site 405531004831 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405531004832 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 405531004833 aspartate ammonia-lyase; Provisional; Region: PRK14515 405531004834 Aspartase; Region: Aspartase; cd01357 405531004835 active sites [active] 405531004836 tetramer interface [polypeptide binding]; other site 405531004837 malate dehydrogenase; Provisional; Region: PRK13529 405531004838 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405531004839 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 405531004840 NAD(P) binding site [chemical binding]; other site 405531004841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531004842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531004843 ATP binding site [chemical binding]; other site 405531004844 Mg2+ binding site [ion binding]; other site 405531004845 G-X-G motif; other site 405531004846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531004847 Response regulator receiver domain; Region: Response_reg; pfam00072 405531004848 active site 405531004849 phosphorylation site [posttranslational modification] 405531004850 intermolecular recognition site; other site 405531004851 dimerization interface [polypeptide binding]; other site 405531004852 YcbB domain; Region: YcbB; pfam08664 405531004853 SWIM zinc finger; Region: SWIM; pfam04434 405531004854 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 405531004855 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405531004856 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531004857 ATP binding site [chemical binding]; other site 405531004858 putative Mg++ binding site [ion binding]; other site 405531004859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531004860 nucleotide binding region [chemical binding]; other site 405531004861 ATP-binding site [chemical binding]; other site 405531004862 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 405531004863 dimer interface [polypeptide binding]; other site 405531004864 active site 405531004865 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 405531004866 putative dimer interface [polypeptide binding]; other site 405531004867 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531004868 aspartate kinase; Reviewed; Region: PRK06635 405531004869 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 405531004870 putative nucleotide binding site [chemical binding]; other site 405531004871 putative catalytic residues [active] 405531004872 putative Mg ion binding site [ion binding]; other site 405531004873 putative aspartate binding site [chemical binding]; other site 405531004874 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 405531004875 putative allosteric regulatory site; other site 405531004876 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 405531004877 putative allosteric regulatory residue; other site 405531004878 Lysine riboswitch 405531004879 DoxX-like family; Region: DoxX_3; pfam13781 405531004880 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 405531004881 YndJ-like protein; Region: YndJ; pfam14158 405531004882 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405531004883 putative active site [active] 405531004884 nucleotide binding site [chemical binding]; other site 405531004885 nudix motif; other site 405531004886 putative metal binding site [ion binding]; other site 405531004887 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531004888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531004889 putative substrate translocation pore; other site 405531004890 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 405531004891 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531004892 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531004893 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531004894 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531004895 putative substrate translocation pore; other site 405531004896 CDK-activating kinase assembly factor MAT1; Region: MAT1; pfam06391 405531004897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531004898 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531004899 putative substrate translocation pore; other site 405531004900 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 405531004901 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405531004902 dimer interface [polypeptide binding]; other site 405531004903 active site 405531004904 CoA binding pocket [chemical binding]; other site 405531004905 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405531004906 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405531004907 HflX GTPase family; Region: HflX; cd01878 405531004908 G1 box; other site 405531004909 GTP/Mg2+ binding site [chemical binding]; other site 405531004910 Switch I region; other site 405531004911 G2 box; other site 405531004912 G3 box; other site 405531004913 Switch II region; other site 405531004914 G4 box; other site 405531004915 G5 box; other site 405531004916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531004917 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531004918 putative substrate translocation pore; other site 405531004919 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405531004920 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405531004921 dimer interface [polypeptide binding]; other site 405531004922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531004923 catalytic residue [active] 405531004924 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531004925 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 405531004926 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405531004927 Na2 binding site [ion binding]; other site 405531004928 putative substrate binding site 1 [chemical binding]; other site 405531004929 Na binding site 1 [ion binding]; other site 405531004930 putative substrate binding site 2 [chemical binding]; other site 405531004931 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531004932 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 405531004933 NodB motif; other site 405531004934 putative active site [active] 405531004935 putative catalytic site [active] 405531004936 putative Zn binding site [ion binding]; other site 405531004937 Mor transcription activator family; Region: Mor; cl02360 405531004938 Predicted membrane protein [Function unknown]; Region: COG2323 405531004939 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 405531004940 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405531004941 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405531004942 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405531004943 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405531004944 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 405531004945 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405531004946 short chain dehydrogenase; Provisional; Region: PRK12747 405531004947 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405531004948 NADP binding site [chemical binding]; other site 405531004949 homodimer interface [polypeptide binding]; other site 405531004950 active site 405531004951 substrate binding site [chemical binding]; other site 405531004952 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405531004953 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405531004954 homodimer interface [polypeptide binding]; other site 405531004955 substrate-cofactor binding pocket; other site 405531004956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531004957 catalytic residue [active] 405531004958 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 405531004959 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405531004960 PYR/PP interface [polypeptide binding]; other site 405531004961 dimer interface [polypeptide binding]; other site 405531004962 TPP binding site [chemical binding]; other site 405531004963 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405531004964 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405531004965 TPP-binding site [chemical binding]; other site 405531004966 dimer interface [polypeptide binding]; other site 405531004967 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 405531004968 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405531004969 putative valine binding site [chemical binding]; other site 405531004970 dimer interface [polypeptide binding]; other site 405531004971 ketol-acid reductoisomerase; Provisional; Region: PRK05479 405531004972 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405531004973 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405531004974 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 405531004975 threonine dehydratase; Validated; Region: PRK08639 405531004976 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405531004977 tetramer interface [polypeptide binding]; other site 405531004978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531004979 catalytic residue [active] 405531004980 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 405531004981 putative Ile/Val binding site [chemical binding]; other site 405531004982 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 405531004983 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 405531004984 putative active site [active] 405531004985 putative metal binding site [ion binding]; other site 405531004986 Protein of unknown function (DUF554); Region: DUF554; pfam04474 405531004987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531004988 Coenzyme A binding pocket [chemical binding]; other site 405531004989 drug efflux system protein MdtG; Provisional; Region: PRK09874 405531004990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531004991 putative substrate translocation pore; other site 405531004992 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 405531004993 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 405531004994 putative active site [active] 405531004995 metal binding site [ion binding]; metal-binding site 405531004996 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405531004997 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531004998 LytTr DNA-binding domain; Region: LytTR; pfam04397 405531004999 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405531005000 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 405531005001 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 405531005002 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 405531005003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005004 Coenzyme A binding pocket [chemical binding]; other site 405531005005 5-methylthioadenosine/S-adenosylhomocysteine deaminase; Provisional; Region: PRK15493 405531005006 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 405531005007 active site 405531005008 putative substrate binding pocket [chemical binding]; other site 405531005009 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531005010 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531005011 peptide binding site [polypeptide binding]; other site 405531005012 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531005013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005014 Coenzyme A binding pocket [chemical binding]; other site 405531005015 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531005016 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531005017 active site 405531005018 phosphorylation site [posttranslational modification] 405531005019 intermolecular recognition site; other site 405531005020 dimerization interface [polypeptide binding]; other site 405531005021 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531005022 DNA binding site [nucleotide binding] 405531005023 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531005024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531005025 dimerization interface [polypeptide binding]; other site 405531005026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531005027 dimer interface [polypeptide binding]; other site 405531005028 phosphorylation site [posttranslational modification] 405531005029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531005030 ATP binding site [chemical binding]; other site 405531005031 Mg2+ binding site [ion binding]; other site 405531005032 G-X-G motif; other site 405531005033 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531005034 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531005035 manganese transport protein MntH; Reviewed; Region: PRK00701 405531005036 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 405531005037 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 405531005038 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 405531005039 active site residue [active] 405531005040 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 405531005041 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 405531005042 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405531005043 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405531005044 ydaO/yuaA leader 405531005045 Amino acid permease; Region: AA_permease_2; pfam13520 405531005046 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531005047 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531005048 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531005049 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405531005050 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405531005051 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 405531005052 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531005053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531005054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531005055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005056 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531005057 Coenzyme A binding pocket [chemical binding]; other site 405531005058 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 405531005059 CAAX protease self-immunity; Region: Abi; pfam02517 405531005060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531005061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531005062 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405531005063 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531005064 DNA binding residues [nucleotide binding] 405531005065 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405531005066 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 405531005067 intersubunit interface [polypeptide binding]; other site 405531005068 active site 405531005069 catalytic residue [active] 405531005070 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405531005071 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405531005072 Nucleoside recognition; Region: Gate; pfam07670 405531005073 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405531005074 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405531005075 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405531005076 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405531005077 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405531005078 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405531005079 active site 405531005080 catalytic motif [active] 405531005081 Zn binding site [ion binding]; other site 405531005082 Homeodomain-like domain; Region: HTH_23; pfam13384 405531005083 putative transposase OrfB; Reviewed; Region: PHA02517 405531005084 HTH-like domain; Region: HTH_21; pfam13276 405531005085 Integrase core domain; Region: rve; pfam00665 405531005086 Integrase core domain; Region: rve_2; pfam13333 405531005087 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 405531005088 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 405531005089 LXG domain of WXG superfamily; Region: LXG; pfam04740 405531005090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405531005091 Helix-turn-helix domain; Region: HTH_28; pfam13518 405531005092 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 405531005093 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405531005094 hypothetical protein; Provisional; Region: PRK01631 405531005095 proline aminopeptidase P II; Provisional; Region: PRK10879 405531005096 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 405531005097 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 405531005098 active site 405531005099 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405531005100 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405531005101 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 405531005102 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405531005103 Multicopper oxidase; Region: Cu-oxidase; pfam00394 405531005104 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405531005105 DNA topoisomerase III; Provisional; Region: PRK07726 405531005106 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405531005107 active site 405531005108 putative interdomain interaction site [polypeptide binding]; other site 405531005109 putative metal-binding site [ion binding]; other site 405531005110 putative nucleotide binding site [chemical binding]; other site 405531005111 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405531005112 domain I; other site 405531005113 DNA binding groove [nucleotide binding] 405531005114 phosphate binding site [ion binding]; other site 405531005115 domain II; other site 405531005116 domain III; other site 405531005117 nucleotide binding site [chemical binding]; other site 405531005118 catalytic site [active] 405531005119 domain IV; other site 405531005120 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405531005121 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405531005122 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405531005123 Sodium Bile acid symporter family; Region: SBF; cl17470 405531005124 azoreductase; Provisional; Region: PRK13555 405531005125 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405531005126 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531005127 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 405531005128 dimer interface [polypeptide binding]; other site 405531005129 substrate binding site [chemical binding]; other site 405531005130 metal binding site [ion binding]; metal-binding site 405531005131 CopC domain; Region: CopC; pfam04234 405531005132 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 405531005133 YtkA-like; Region: YtkA; pfam13115 405531005134 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 405531005135 EamA-like transporter family; Region: EamA; pfam00892 405531005136 EamA-like transporter family; Region: EamA; pfam00892 405531005137 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531005138 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531005139 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531005140 dimerization interface [polypeptide binding]; other site 405531005141 Predicted transcriptional regulator [Transcription]; Region: COG1959 405531005142 Transcriptional regulator; Region: Rrf2; pfam02082 405531005143 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 405531005144 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 405531005145 catalytic residues [active] 405531005146 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405531005147 dimer interface [polypeptide binding]; other site 405531005148 FMN binding site [chemical binding]; other site 405531005149 amidase; Provisional; Region: PRK06707 405531005150 Amidase; Region: Amidase; cl11426 405531005151 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405531005152 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405531005153 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405531005154 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531005155 NAD binding site [chemical binding]; other site 405531005156 dimer interface [polypeptide binding]; other site 405531005157 substrate binding site [chemical binding]; other site 405531005158 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405531005159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531005160 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405531005161 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405531005162 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405531005163 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 405531005164 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 405531005165 putative ligand binding site [chemical binding]; other site 405531005166 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 405531005167 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 405531005168 Walker A/P-loop; other site 405531005169 ATP binding site [chemical binding]; other site 405531005170 Q-loop/lid; other site 405531005171 ABC transporter signature motif; other site 405531005172 Walker B; other site 405531005173 D-loop; other site 405531005174 H-loop/switch region; other site 405531005175 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 405531005176 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 405531005177 Walker A/P-loop; other site 405531005178 ATP binding site [chemical binding]; other site 405531005179 Q-loop/lid; other site 405531005180 ABC transporter signature motif; other site 405531005181 Walker B; other site 405531005182 D-loop; other site 405531005183 H-loop/switch region; other site 405531005184 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405531005185 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 405531005186 TM-ABC transporter signature motif; other site 405531005187 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 405531005188 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 405531005189 TM-ABC transporter signature motif; other site 405531005190 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531005191 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531005192 LysR substrate binding domain; Region: LysR_substrate; pfam03466 405531005193 dimerization interface [polypeptide binding]; other site 405531005194 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 405531005195 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405531005196 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 405531005197 substrate binding site; other site 405531005198 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 405531005199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531005200 NAD(P) binding site [chemical binding]; other site 405531005201 active site 405531005202 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405531005203 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405531005204 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 405531005205 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 405531005206 putative dimer interface [polypeptide binding]; other site 405531005207 active site pocket [active] 405531005208 putative cataytic base [active] 405531005209 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 405531005210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531005211 motif II; other site 405531005212 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405531005213 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 405531005214 acyl-activating enzyme (AAE) consensus motif; other site 405531005215 AMP binding site [chemical binding]; other site 405531005216 active site 405531005217 CoA binding site [chemical binding]; other site 405531005218 Phosphopantetheine attachment site; Region: PP-binding; cl09936 405531005219 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 405531005220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531005221 Walker A/P-loop; other site 405531005222 ATP binding site [chemical binding]; other site 405531005223 Q-loop/lid; other site 405531005224 ABC transporter signature motif; other site 405531005225 Walker B; other site 405531005226 D-loop; other site 405531005227 H-loop/switch region; other site 405531005228 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405531005229 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405531005230 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 405531005231 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 405531005232 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531005233 Glycosyltransferase like family 2; Region: Glyco_tranf_2_2; pfam10111 405531005234 active site 405531005235 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 405531005236 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 405531005237 Chorismate lyase; Region: Chor_lyase; cl01230 405531005238 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 405531005239 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531005240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531005241 putative Zn2+ binding site [ion binding]; other site 405531005242 putative DNA binding site [nucleotide binding]; other site 405531005243 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 405531005244 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405531005245 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 405531005246 fimbrial outer membrane usher protein PefC; Provisional; Region: PRK15213 405531005247 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 405531005248 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405531005249 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405531005250 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405531005251 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531005252 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 405531005253 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531005254 Walker A/P-loop; other site 405531005255 ATP binding site [chemical binding]; other site 405531005256 Q-loop/lid; other site 405531005257 ABC transporter signature motif; other site 405531005258 Walker B; other site 405531005259 D-loop; other site 405531005260 H-loop/switch region; other site 405531005261 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 405531005262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531005263 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 405531005264 Walker A/P-loop; other site 405531005265 ATP binding site [chemical binding]; other site 405531005266 Q-loop/lid; other site 405531005267 ABC transporter signature motif; other site 405531005268 Walker B; other site 405531005269 D-loop; other site 405531005270 H-loop/switch region; other site 405531005271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405531005272 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405531005273 active site 405531005274 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531005275 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531005276 active site 405531005277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531005278 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531005279 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405531005280 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405531005281 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405531005282 inhibitor-cofactor binding pocket; inhibition site 405531005283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531005284 catalytic residue [active] 405531005285 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405531005286 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405531005287 trimer interface [polypeptide binding]; other site 405531005288 active site 405531005289 substrate binding site [chemical binding]; other site 405531005290 CoA binding site [chemical binding]; other site 405531005291 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405531005292 putative dimer interface [polypeptide binding]; other site 405531005293 catalytic triad [active] 405531005294 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531005295 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405531005296 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 405531005297 dimer interface [polypeptide binding]; other site 405531005298 FMN binding site [chemical binding]; other site 405531005299 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531005300 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531005301 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531005302 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405531005303 NlpC/P60 family; Region: NLPC_P60; pfam00877 405531005304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531005305 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531005306 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531005307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531005308 Walker A/P-loop; other site 405531005309 ATP binding site [chemical binding]; other site 405531005310 Q-loop/lid; other site 405531005311 ABC transporter signature motif; other site 405531005312 Walker B; other site 405531005313 D-loop; other site 405531005314 H-loop/switch region; other site 405531005315 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531005316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531005317 active site 405531005318 phosphorylation site [posttranslational modification] 405531005319 intermolecular recognition site; other site 405531005320 dimerization interface [polypeptide binding]; other site 405531005321 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531005322 DNA binding site [nucleotide binding] 405531005323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531005324 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531005325 dimerization interface [polypeptide binding]; other site 405531005326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531005327 dimer interface [polypeptide binding]; other site 405531005328 phosphorylation site [posttranslational modification] 405531005329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531005330 ATP binding site [chemical binding]; other site 405531005331 Mg2+ binding site [ion binding]; other site 405531005332 G-X-G motif; other site 405531005333 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 405531005334 classical (c) SDRs; Region: SDR_c; cd05233 405531005335 NAD(P) binding site [chemical binding]; other site 405531005336 active site 405531005337 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405531005338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531005339 S-adenosylmethionine binding site [chemical binding]; other site 405531005340 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 405531005341 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531005342 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405531005343 NodB motif; other site 405531005344 active site 405531005345 catalytic site [active] 405531005346 metal binding site [ion binding]; metal-binding site 405531005347 SdpI/YhfL protein family; Region: SdpI; pfam13630 405531005348 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405531005349 nudix motif; other site 405531005350 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 405531005351 homoserine dehydrogenase; Provisional; Region: PRK06349 405531005352 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405531005353 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405531005354 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405531005355 threonine synthase; Reviewed; Region: PRK06721 405531005356 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 405531005357 homodimer interface [polypeptide binding]; other site 405531005358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531005359 catalytic residue [active] 405531005360 homoserine kinase; Provisional; Region: PRK01212 405531005361 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405531005362 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405531005363 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 405531005364 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 405531005365 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531005366 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405531005367 NodB motif; other site 405531005368 active site 405531005369 catalytic site [active] 405531005370 Zn binding site [ion binding]; other site 405531005371 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405531005372 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405531005373 MgtC family; Region: MgtC; pfam02308 405531005374 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405531005375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005376 Coenzyme A binding pocket [chemical binding]; other site 405531005377 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405531005378 IucA / IucC family; Region: IucA_IucC; pfam04183 405531005379 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405531005380 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405531005381 IucA / IucC family; Region: IucA_IucC; pfam04183 405531005382 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405531005383 acyl-CoA synthetase; Validated; Region: PRK08308 405531005384 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405531005385 acyl-activating enzyme (AAE) consensus motif; other site 405531005386 AMP binding site [chemical binding]; other site 405531005387 active site 405531005388 CoA binding site [chemical binding]; other site 405531005389 acyl carrier protein; Provisional; Region: PRK07639 405531005390 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405531005391 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 405531005392 Metal-binding active site; metal-binding site 405531005393 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531005394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531005395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531005396 putative substrate translocation pore; other site 405531005397 Lysine efflux permease [General function prediction only]; Region: COG1279 405531005398 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531005399 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531005400 DNA-binding site [nucleotide binding]; DNA binding site 405531005401 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531005402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531005403 homodimer interface [polypeptide binding]; other site 405531005404 catalytic residue [active] 405531005405 Protein of unknown function (DUF3933); Region: DUF3933; pfam13069 405531005406 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405531005407 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 405531005408 active site 405531005409 nucleophile elbow; other site 405531005410 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405531005411 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405531005412 Domain of unknown function (DUF4083); Region: DUF4083; pfam13314 405531005413 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405531005414 nudix motif; other site 405531005415 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 405531005416 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 405531005417 homodimer interface [polypeptide binding]; other site 405531005418 NAD binding pocket [chemical binding]; other site 405531005419 ATP binding pocket [chemical binding]; other site 405531005420 Mg binding site [ion binding]; other site 405531005421 active-site loop [active] 405531005422 SIR2-like domain; Region: SIR2_2; pfam13289 405531005423 hypothetical protein; Region: PHA00727 405531005424 Helix-turn-helix domain; Region: HTH_36; pfam13730 405531005425 Phage terminase, small subunit; Region: Terminase_4; pfam05119 405531005426 Phage portal protein; Region: Phage_portal; pfam04860 405531005427 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405531005428 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 405531005429 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405531005430 Phage capsid family; Region: Phage_capsid; pfam05065 405531005431 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405531005432 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405531005433 catalytic residues [active] 405531005434 catalytic nucleophile [active] 405531005435 Recombinase; Region: Recombinase; pfam07508 405531005436 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405531005437 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405531005438 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405531005439 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 405531005440 active site 405531005441 catalytic residues [active] 405531005442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531005443 dimerization interface [polypeptide binding]; other site 405531005444 putative DNA binding site [nucleotide binding]; other site 405531005445 putative Zn2+ binding site [ion binding]; other site 405531005446 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531005447 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531005448 active site 405531005449 catalytic tetrad [active] 405531005450 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405531005451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531005452 putative substrate translocation pore; other site 405531005453 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 405531005454 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405531005455 DinB superfamily; Region: DinB_2; pfam12867 405531005456 GTPase RsgA; Reviewed; Region: PRK01889 405531005457 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405531005458 RNA binding site [nucleotide binding]; other site 405531005459 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405531005460 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405531005461 GTP/Mg2+ binding site [chemical binding]; other site 405531005462 G4 box; other site 405531005463 G5 box; other site 405531005464 G1 box; other site 405531005465 Switch I region; other site 405531005466 G2 box; other site 405531005467 G3 box; other site 405531005468 Switch II region; other site 405531005469 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 405531005470 Cache domain; Region: Cache_1; pfam02743 405531005471 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531005472 dimerization interface [polypeptide binding]; other site 405531005473 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531005474 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531005475 dimer interface [polypeptide binding]; other site 405531005476 putative CheW interface [polypeptide binding]; other site 405531005477 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 405531005478 Uncharacterized membrane protein [Function unknown]; Region: COG3949 405531005479 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405531005480 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405531005481 dimerization interface [polypeptide binding]; other site 405531005482 DPS ferroxidase diiron center [ion binding]; other site 405531005483 ion pore; other site 405531005484 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 405531005485 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405531005486 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 405531005487 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 405531005488 Protein of unknown function (DUF3896); Region: DUF3896; pfam13035 405531005489 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 405531005490 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531005491 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531005492 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531005493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531005494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531005495 active site 405531005496 catalytic tetrad [active] 405531005497 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405531005498 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 405531005499 P-loop, Walker A motif; other site 405531005500 Base recognition motif; other site 405531005501 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405531005502 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531005503 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005504 Coenzyme A binding pocket [chemical binding]; other site 405531005505 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 405531005506 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 405531005507 metal binding site [ion binding]; metal-binding site 405531005508 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 405531005509 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405531005510 NAD binding site [chemical binding]; other site 405531005511 active site 405531005512 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405531005513 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 405531005514 active site 405531005515 FMN binding site [chemical binding]; other site 405531005516 substrate binding site [chemical binding]; other site 405531005517 homotetramer interface [polypeptide binding]; other site 405531005518 catalytic residue [active] 405531005519 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 405531005520 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405531005521 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405531005522 DNA binding site [nucleotide binding] 405531005523 active site 405531005524 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405531005525 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531005526 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531005527 peptide binding site [polypeptide binding]; other site 405531005528 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 405531005529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531005530 active site 405531005531 metal binding site [ion binding]; metal-binding site 405531005532 short chain dehydrogenase; Provisional; Region: PRK08309 405531005533 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531005534 catalytic core [active] 405531005535 CotH protein; Region: CotH; pfam08757 405531005536 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 405531005537 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 405531005538 nudix motif; other site 405531005539 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531005540 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531005541 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405531005542 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405531005543 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 405531005544 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 405531005545 Cl binding site [ion binding]; other site 405531005546 oligomer interface [polypeptide binding]; other site 405531005547 Predicted permeases [General function prediction only]; Region: COG0701 405531005548 Predicted membrane protein [Function unknown]; Region: COG3689 405531005549 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405531005550 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 405531005551 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405531005552 putative active site [active] 405531005553 catalytic site [active] 405531005554 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405531005555 putative active site [active] 405531005556 catalytic site [active] 405531005557 Coat F domain; Region: Coat_F; pfam07875 405531005558 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405531005559 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405531005560 NAD binding site [chemical binding]; other site 405531005561 substrate binding site [chemical binding]; other site 405531005562 putative active site [active] 405531005563 Protein of unknown function (DUF456); Region: DUF456; pfam04306 405531005564 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405531005565 Domain of unknown function DUF21; Region: DUF21; pfam01595 405531005566 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405531005567 Transporter associated domain; Region: CorC_HlyC; smart01091 405531005568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531005569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531005570 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 405531005571 FOG: CBS domain [General function prediction only]; Region: COG0517 405531005572 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405531005573 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405531005574 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 405531005575 dimer interface [polypeptide binding]; other site 405531005576 putative tRNA-binding site [nucleotide binding]; other site 405531005577 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405531005578 DinB superfamily; Region: DinB_2; pfam12867 405531005579 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405531005580 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405531005581 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531005582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005583 Coenzyme A binding pocket [chemical binding]; other site 405531005584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531005585 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405531005586 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405531005587 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405531005588 nudix motif; other site 405531005589 amidase; Provisional; Region: PRK06828 405531005590 Amidase; Region: Amidase; pfam01425 405531005591 potential frameshift: common BLAST hit: gi|30020192|ref|NP_831823.1| macrolide-efflux protein 405531005592 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531005593 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 405531005594 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 405531005595 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405531005596 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 405531005597 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 405531005598 stage II sporulation protein P; Region: spore_II_P; TIGR02867 405531005599 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531005600 catalytic core [active] 405531005601 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531005602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531005603 active site 405531005604 motif I; other site 405531005605 motif II; other site 405531005606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531005607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531005608 MarR family; Region: MarR; pfam01047 405531005609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531005610 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405531005611 putative substrate translocation pore; other site 405531005612 DinB superfamily; Region: DinB_2; pfam12867 405531005613 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 405531005614 alanine racemase; Reviewed; Region: alr; PRK00053 405531005615 active site 405531005616 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405531005617 dimer interface [polypeptide binding]; other site 405531005618 substrate binding site [chemical binding]; other site 405531005619 catalytic residues [active] 405531005620 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405531005621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531005622 S-adenosylmethionine binding site [chemical binding]; other site 405531005623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005624 Coenzyme A binding pocket [chemical binding]; other site 405531005625 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005626 Coenzyme A binding pocket [chemical binding]; other site 405531005627 Phosphotransferase enzyme family; Region: APH; pfam01636 405531005628 active site 405531005629 ATP binding site [chemical binding]; other site 405531005630 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531005631 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405531005632 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405531005633 active site 405531005634 TDP-binding site; other site 405531005635 acceptor substrate-binding pocket; other site 405531005636 homodimer interface [polypeptide binding]; other site 405531005637 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531005638 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531005639 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531005640 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531005641 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531005642 DNA-binding site [nucleotide binding]; DNA binding site 405531005643 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531005644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531005645 homodimer interface [polypeptide binding]; other site 405531005646 catalytic residue [active] 405531005647 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005648 Coenzyme A binding pocket [chemical binding]; other site 405531005649 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531005650 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 405531005651 active site 405531005652 metal binding site [ion binding]; metal-binding site 405531005653 Src Homology 3 domain superfamily; Region: SH3; cl17036 405531005654 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405531005655 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531005656 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005657 Coenzyme A binding pocket [chemical binding]; other site 405531005658 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531005659 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405531005660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531005661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005662 Coenzyme A binding pocket [chemical binding]; other site 405531005663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531005665 Coenzyme A binding pocket [chemical binding]; other site 405531005666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 405531005667 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405531005668 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 405531005669 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 405531005670 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 405531005671 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 405531005672 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 405531005673 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 405531005674 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 405531005675 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405531005676 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405531005677 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 405531005678 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405531005679 nucleophilic elbow; other site 405531005680 catalytic triad; other site 405531005681 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 405531005682 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 405531005683 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405531005684 nucleophilic elbow; other site 405531005685 catalytic triad; other site 405531005686 Domain of unknown function (DUF3952); Region: DUF3952; pfam13130 405531005687 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405531005688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005689 Coenzyme A binding pocket [chemical binding]; other site 405531005690 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405531005691 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531005692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531005693 S-adenosylmethionine binding site [chemical binding]; other site 405531005694 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 405531005695 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 405531005696 Potassium binding sites [ion binding]; other site 405531005697 Cesium cation binding sites [ion binding]; other site 405531005698 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 405531005699 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405531005700 ATP binding site [chemical binding]; other site 405531005701 putative Mg++ binding site [ion binding]; other site 405531005702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531005703 nucleotide binding region [chemical binding]; other site 405531005704 ATP-binding site [chemical binding]; other site 405531005705 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405531005706 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531005707 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405531005708 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405531005709 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405531005710 NADP binding site [chemical binding]; other site 405531005711 dimer interface [polypeptide binding]; other site 405531005712 RNA polymerase sigma factor; Provisional; Region: PRK12543 405531005713 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531005714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531005715 DNA binding residues [nucleotide binding] 405531005716 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 405531005717 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 405531005718 ABC1 family; Region: ABC1; cl17513 405531005719 MSEP-CTERM protein; Region: MSEP-CTERM; TIGR04286 405531005720 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 405531005721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531005722 Protein of unknown function (DUF3925); Region: DUF3925; pfam13063 405531005723 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 405531005724 catalytic residues [active] 405531005725 dimer interface [polypeptide binding]; other site 405531005726 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 405531005727 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 405531005728 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 405531005729 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405531005730 Protein of unknown function DUF58; Region: DUF58; pfam01882 405531005731 MoxR-like ATPases [General function prediction only]; Region: COG0714 405531005732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531005733 Walker A motif; other site 405531005734 ATP binding site [chemical binding]; other site 405531005735 Walker B motif; other site 405531005736 arginine finger; other site 405531005737 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 405531005738 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 405531005739 [4Fe-4S] binding site [ion binding]; other site 405531005740 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405531005741 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405531005742 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405531005743 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 405531005744 molybdopterin cofactor binding site; other site 405531005745 nitrate reductase, beta subunit; Region: narH; TIGR01660 405531005746 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 405531005747 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 405531005748 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405531005749 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405531005750 ligand binding site [chemical binding]; other site 405531005751 flexible hinge region; other site 405531005752 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405531005753 putative switch regulator; other site 405531005754 non-specific DNA interactions [nucleotide binding]; other site 405531005755 DNA binding site [nucleotide binding] 405531005756 sequence specific DNA binding site [nucleotide binding]; other site 405531005757 putative cAMP binding site [chemical binding]; other site 405531005758 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405531005759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531005760 FeS/SAM binding site; other site 405531005761 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405531005762 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405531005763 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405531005764 ATP binding site [chemical binding]; other site 405531005765 substrate interface [chemical binding]; other site 405531005766 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405531005767 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405531005768 dimer interface [polypeptide binding]; other site 405531005769 putative functional site; other site 405531005770 putative MPT binding site; other site 405531005771 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405531005772 MoaE homodimer interface [polypeptide binding]; other site 405531005773 MoaD interaction [polypeptide binding]; other site 405531005774 active site residues [active] 405531005775 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405531005776 MoaE interaction surface [polypeptide binding]; other site 405531005777 MoeB interaction surface [polypeptide binding]; other site 405531005778 thiocarboxylated glycine; other site 405531005779 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 405531005780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531005781 putative substrate translocation pore; other site 405531005782 Predicted permeases [General function prediction only]; Region: COG0679 405531005783 precorrin-2 dehydrogenase; Validated; Region: PRK06719 405531005784 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 405531005785 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 405531005786 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 405531005787 putative active site [active] 405531005788 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 405531005789 putative active site [active] 405531005790 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 405531005791 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405531005792 active site 405531005793 SAM binding site [chemical binding]; other site 405531005794 homodimer interface [polypeptide binding]; other site 405531005795 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 405531005796 [2Fe-2S] cluster binding site [ion binding]; other site 405531005797 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 405531005798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531005799 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405531005800 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405531005801 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405531005802 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 405531005803 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 405531005804 Hemerythrin-like domain; Region: Hr-like; cd12108 405531005805 Excalibur calcium-binding domain; Region: Excalibur; smart00894 405531005806 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405531005807 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405531005808 PGAP1-like protein; Region: PGAP1; pfam07819 405531005809 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 405531005810 YolD-like protein; Region: YolD; pfam08863 405531005811 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531005812 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 405531005813 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531005814 Zn2+ binding site [ion binding]; other site 405531005815 Mg2+ binding site [ion binding]; other site 405531005816 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531005817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531005818 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531005819 ABC transporter; Region: ABC_tran_2; pfam12848 405531005820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531005821 Bax inhibitor 1 like; Region: BaxI_1; cl17691 405531005822 Domain of unknown function (DUF4318); Region: DUF4318; pfam14201 405531005823 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405531005824 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405531005825 dimer interface [polypeptide binding]; other site 405531005826 ssDNA binding site [nucleotide binding]; other site 405531005827 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531005828 AAA domain; Region: AAA_18; pfam13238 405531005829 AAA domain; Region: AAA_17; pfam13207 405531005830 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 405531005831 Virulence factor; Region: Virulence_fact; pfam13769 405531005832 HEAT repeats; Region: HEAT_2; pfam13646 405531005833 HEAT repeats; Region: HEAT_2; pfam13646 405531005834 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 405531005835 Protein of unknown function, DUF393; Region: DUF393; pfam04134 405531005836 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405531005837 Brix domain; Region: Brix; cl00935 405531005838 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 405531005839 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 405531005840 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405531005841 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405531005842 active site 405531005843 HIGH motif; other site 405531005844 KMSK motif region; other site 405531005845 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 405531005846 tRNA binding surface [nucleotide binding]; other site 405531005847 anticodon binding site; other site 405531005848 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005849 binding surface 405531005850 TPR motif; other site 405531005851 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 405531005852 putative active site [active] 405531005853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005854 binding surface 405531005855 TPR motif; other site 405531005856 TPR repeat; Region: TPR_11; pfam13414 405531005857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005858 binding surface 405531005859 TPR motif; other site 405531005860 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405531005861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005862 binding surface 405531005863 TPR motif; other site 405531005864 TPR repeat; Region: TPR_11; pfam13414 405531005865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005866 binding surface 405531005867 TPR motif; other site 405531005868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005869 binding surface 405531005870 TPR motif; other site 405531005871 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405531005872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531005873 binding surface 405531005874 TPR motif; other site 405531005875 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 405531005876 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405531005877 HIGH motif; other site 405531005878 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405531005879 active site 405531005880 KMSKS motif; other site 405531005881 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 405531005882 tRNA binding surface [nucleotide binding]; other site 405531005883 anticodon binding site; other site 405531005884 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405531005885 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405531005886 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405531005887 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 405531005888 Zn binding site [ion binding]; other site 405531005889 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 405531005890 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405531005891 Dimer interface [polypeptide binding]; other site 405531005892 anticodon binding site; other site 405531005893 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405531005894 homodimer interface [polypeptide binding]; other site 405531005895 motif 1; other site 405531005896 motif 2; other site 405531005897 active site 405531005898 motif 3; other site 405531005899 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 405531005900 Na2 binding site [ion binding]; other site 405531005901 putative substrate binding site 1 [chemical binding]; other site 405531005902 Na binding site 1 [ion binding]; other site 405531005903 putative substrate binding site 2 [chemical binding]; other site 405531005904 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 405531005905 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531005906 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 405531005907 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 405531005908 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405531005909 Eukaryotic phosphomannomutase; Region: PMM; cl17107 405531005910 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405531005911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531005912 motif II; other site 405531005913 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 405531005914 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405531005915 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 405531005916 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 405531005917 putative active site [active] 405531005918 metal binding site [ion binding]; metal-binding site 405531005919 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405531005920 aspartate racemase; Region: asp_race; TIGR00035 405531005921 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 405531005922 homodimer interaction site [polypeptide binding]; other site 405531005923 cofactor binding site; other site 405531005924 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531005925 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005926 Coenzyme A binding pocket [chemical binding]; other site 405531005927 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405531005928 Predicted transcriptional regulator [Transcription]; Region: COG3655 405531005929 sequence-specific DNA binding site [nucleotide binding]; other site 405531005930 salt bridge; other site 405531005931 hypothetical protein; Validated; Region: PRK06769 405531005932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531005933 active site 405531005934 motif I; other site 405531005935 motif II; other site 405531005936 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531005937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531005938 Coenzyme A binding pocket [chemical binding]; other site 405531005939 potential frameshift: common BLAST hit: gi|218233650|ref|YP_002366929.1| ABC transporter ATP-binding protein 405531005940 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531005941 Walker A/P-loop; other site 405531005942 ATP binding site [chemical binding]; other site 405531005943 Q-loop/lid; other site 405531005944 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531005945 ABC transporter signature motif; other site 405531005946 Walker B; other site 405531005947 D-loop; other site 405531005948 H-loop/switch region; other site 405531005949 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 405531005950 YpjP-like protein; Region: YpjP; pfam14005 405531005951 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405531005952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531005953 motif II; other site 405531005954 hypothetical protein; Provisional; Region: PRK06724 405531005955 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531005956 active site 405531005957 metal binding site [ion binding]; metal-binding site 405531005958 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405531005959 Phosphotransferase enzyme family; Region: APH; pfam01636 405531005960 active site 405531005961 substrate binding site [chemical binding]; other site 405531005962 ATP binding site [chemical binding]; other site 405531005963 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531005964 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531005965 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 405531005966 thymidylate synthase; Region: thym_sym; TIGR03284 405531005967 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 405531005968 dimerization interface [polypeptide binding]; other site 405531005969 active site 405531005970 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405531005971 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 405531005972 folate binding site [chemical binding]; other site 405531005973 NADP+ binding site [chemical binding]; other site 405531005974 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 405531005975 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531005976 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405531005977 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531005978 azoreductase; Reviewed; Region: PRK00170 405531005979 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405531005980 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405531005981 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405531005982 putative acyl-acceptor binding pocket; other site 405531005983 Haemolysin-III related; Region: HlyIII; cl03831 405531005984 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405531005985 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 405531005986 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 405531005987 Protein of unknown function (DUF2535); Region: DUF2535; pfam10751 405531005988 EDD domain protein, DegV family; Region: DegV; TIGR00762 405531005989 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405531005990 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405531005991 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405531005992 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 405531005993 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 405531005994 Cu(I) binding site [ion binding]; other site 405531005995 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405531005996 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405531005997 putative dimer interface [polypeptide binding]; other site 405531005998 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 405531005999 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405531006000 active site 405531006001 dimer interface [polypeptide binding]; other site 405531006002 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405531006003 Ligand Binding Site [chemical binding]; other site 405531006004 Molecular Tunnel; other site 405531006005 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531006006 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405531006007 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405531006008 active site 405531006009 metal binding site [ion binding]; metal-binding site 405531006010 Bacterial SH3 domain; Region: SH3_3; cl17532 405531006011 Bacterial SH3 domain; Region: SH3_3; cl17532 405531006012 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405531006013 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405531006014 siderophore binding site; other site 405531006015 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405531006016 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405531006017 homodimer interface [polypeptide binding]; other site 405531006018 substrate-cofactor binding pocket; other site 405531006019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531006020 catalytic residue [active] 405531006021 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 405531006022 FMN binding site [chemical binding]; other site 405531006023 dimer interface [polypeptide binding]; other site 405531006024 Isochorismatase family; Region: Isochorismatase; pfam00857 405531006025 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405531006026 catalytic triad [active] 405531006027 conserved cis-peptide bond; other site 405531006028 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405531006029 nudix motif; other site 405531006030 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405531006031 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405531006032 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405531006033 GAF domain; Region: GAF; pfam01590 405531006034 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531006035 Histidine kinase; Region: HisKA_3; pfam07730 405531006036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531006037 ATP binding site [chemical binding]; other site 405531006038 Mg2+ binding site [ion binding]; other site 405531006039 G-X-G motif; other site 405531006040 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531006041 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531006042 active site 405531006043 phosphorylation site [posttranslational modification] 405531006044 intermolecular recognition site; other site 405531006045 dimerization interface [polypeptide binding]; other site 405531006046 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531006047 DNA binding residues [nucleotide binding] 405531006048 dimerization interface [polypeptide binding]; other site 405531006049 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405531006050 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405531006051 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405531006052 putative active site [active] 405531006053 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 405531006054 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405531006055 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 405531006056 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 405531006057 NAD binding site [chemical binding]; other site 405531006058 substrate binding site [chemical binding]; other site 405531006059 catalytic Zn binding site [ion binding]; other site 405531006060 tetramer interface [polypeptide binding]; other site 405531006061 structural Zn binding site [ion binding]; other site 405531006062 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405531006063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531006064 dimer interface [polypeptide binding]; other site 405531006065 conserved gate region; other site 405531006066 ABC-ATPase subunit interface; other site 405531006067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531006068 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405531006069 dimer interface [polypeptide binding]; other site 405531006070 conserved gate region; other site 405531006071 putative PBP binding loops; other site 405531006072 ABC-ATPase subunit interface; other site 405531006073 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405531006074 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405531006075 N- and C-terminal domain interface [polypeptide binding]; other site 405531006076 active site 405531006077 catalytic site [active] 405531006078 metal binding site [ion binding]; metal-binding site 405531006079 carbohydrate binding site [chemical binding]; other site 405531006080 ATP binding site [chemical binding]; other site 405531006081 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405531006082 GntP family permease; Region: GntP_permease; pfam02447 405531006083 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 405531006084 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405531006085 Protein of unknown function (DUF2711); Region: DUF2711; pfam10924 405531006086 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531006087 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531006088 active site 405531006089 Predicted flavoprotein [General function prediction only]; Region: COG0431 405531006090 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405531006091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006092 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531006093 putative substrate translocation pore; other site 405531006094 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405531006095 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405531006096 putative active site [active] 405531006097 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405531006098 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 405531006099 Walker A/P-loop; other site 405531006100 ATP binding site [chemical binding]; other site 405531006101 Q-loop/lid; other site 405531006102 ABC transporter signature motif; other site 405531006103 Walker B; other site 405531006104 D-loop; other site 405531006105 H-loop/switch region; other site 405531006106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531006107 dimer interface [polypeptide binding]; other site 405531006108 conserved gate region; other site 405531006109 ABC-ATPase subunit interface; other site 405531006110 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 405531006111 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 405531006112 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 405531006113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405531006114 Protein of unknown function (DUF524); Region: DUF524; pfam04411 405531006115 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 405531006116 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405531006117 DNA binding residues [nucleotide binding] 405531006118 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405531006119 Domain of unknown function DUF21; Region: DUF21; pfam01595 405531006120 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405531006121 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 405531006122 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405531006123 NAD(P) binding site [chemical binding]; other site 405531006124 catalytic residues [active] 405531006125 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 405531006126 potential frameshift: common BLAST hit: gi|218234971|ref|YP_002366990.1| sensor histidine kinase 405531006127 Histidine kinase N terminal; Region: HisK_N; pfam09385 405531006128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531006129 dimer interface [polypeptide binding]; other site 405531006130 phosphorylation site [posttranslational modification] 405531006131 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531006132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531006133 ATP binding site [chemical binding]; other site 405531006134 Mg2+ binding site [ion binding]; other site 405531006135 G-X-G motif; other site 405531006136 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405531006137 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 405531006138 hypothetical protein; Provisional; Region: PRK06917 405531006139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531006140 inhibitor-cofactor binding pocket; inhibition site 405531006141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531006142 catalytic residue [active] 405531006143 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 405531006144 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 405531006145 acetylornithine deacetylase; Validated; Region: PRK06915 405531006146 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 405531006147 metal binding site [ion binding]; metal-binding site 405531006148 dimer interface [polypeptide binding]; other site 405531006149 putative beta-lysine N-acetyltransferase; Region: GNAT_ablB; TIGR03827 405531006150 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531006151 PAS domain; Region: PAS; smart00091 405531006152 PAS fold; Region: PAS_4; pfam08448 405531006153 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 405531006154 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531006155 Walker A motif; other site 405531006156 ATP binding site [chemical binding]; other site 405531006157 Walker B motif; other site 405531006158 arginine finger; other site 405531006159 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405531006160 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 405531006161 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531006162 FeS/SAM binding site; other site 405531006163 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 405531006164 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 405531006165 toxin interface [polypeptide binding]; other site 405531006166 Zn binding site [ion binding]; other site 405531006167 hypothetical protein; Provisional; Region: PRK13672 405531006168 Protein of unknown function (DUF3930); Region: DUF3930; pfam13067 405531006169 YozD-like protein; Region: YozD; pfam14162 405531006170 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405531006171 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405531006172 active site 405531006173 ATP binding site [chemical binding]; other site 405531006174 substrate binding site [chemical binding]; other site 405531006175 activation loop (A-loop); other site 405531006176 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 405531006177 SpoOM protein; Region: Spo0M; pfam07070 405531006178 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405531006179 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 405531006180 active site 405531006181 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405531006182 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405531006183 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531006184 catalytic residues [active] 405531006185 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405531006186 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405531006187 active site 405531006188 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 405531006189 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405531006190 YolD-like protein; Region: YolD; pfam08863 405531006191 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405531006192 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 405531006193 classical (c) SDRs; Region: SDR_c; cd05233 405531006194 NAD(P) binding site [chemical binding]; other site 405531006195 active site 405531006196 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 405531006197 KTSC domain; Region: KTSC; pfam13619 405531006198 Transglycosylase; Region: Transgly; pfam00912 405531006199 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405531006200 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531006201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006202 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531006203 putative substrate translocation pore; other site 405531006204 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405531006205 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 405531006206 dimer interface [polypeptide binding]; other site 405531006207 Citrate synthase; Region: Citrate_synt; pfam00285 405531006208 active site 405531006209 coenzyme A binding site [chemical binding]; other site 405531006210 citrylCoA binding site [chemical binding]; other site 405531006211 oxalacetate/citrate binding site [chemical binding]; other site 405531006212 catalytic triad [active] 405531006213 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 405531006214 2-methylcitrate dehydratase; Region: prpD; TIGR02330 405531006215 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405531006216 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405531006217 tetramer interface [polypeptide binding]; other site 405531006218 active site 405531006219 Mg2+/Mn2+ binding site [ion binding]; other site 405531006220 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405531006221 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405531006222 active site 405531006223 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405531006224 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405531006225 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 405531006226 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 405531006227 tetrameric interface [polypeptide binding]; other site 405531006228 NAD binding site [chemical binding]; other site 405531006229 catalytic residues [active] 405531006230 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 405531006231 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 405531006232 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405531006233 substrate binding site [chemical binding]; other site 405531006234 oxyanion hole (OAH) forming residues; other site 405531006235 trimer interface [polypeptide binding]; other site 405531006236 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 405531006237 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 405531006238 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 405531006239 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405531006240 active site 405531006241 metal binding site [ion binding]; metal-binding site 405531006242 DNA binding site [nucleotide binding] 405531006243 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 405531006244 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 405531006245 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405531006246 Walker A/P-loop; other site 405531006247 ATP binding site [chemical binding]; other site 405531006248 Q-loop/lid; other site 405531006249 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 405531006250 ABC transporter signature motif; other site 405531006251 Walker B; other site 405531006252 D-loop; other site 405531006253 H-loop/switch region; other site 405531006254 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531006255 dimerization interface [polypeptide binding]; other site 405531006256 putative DNA binding site [nucleotide binding]; other site 405531006257 putative Zn2+ binding site [ion binding]; other site 405531006258 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; cl11556 405531006259 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405531006260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006261 putative substrate translocation pore; other site 405531006262 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 405531006263 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 405531006264 putative NAD(P) binding site [chemical binding]; other site 405531006265 active site 405531006266 isochorismate synthase DhbC; Validated; Region: PRK06923 405531006267 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405531006268 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 405531006269 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 405531006270 acyl-activating enzyme (AAE) consensus motif; other site 405531006271 active site 405531006272 AMP binding site [chemical binding]; other site 405531006273 substrate binding site [chemical binding]; other site 405531006274 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 405531006275 hydrophobic substrate binding pocket; other site 405531006276 Isochorismatase family; Region: Isochorismatase; pfam00857 405531006277 active site 405531006278 conserved cis-peptide bond; other site 405531006279 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 405531006280 Condensation domain; Region: Condensation; pfam00668 405531006281 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 405531006282 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405531006283 acyl-activating enzyme (AAE) consensus motif; other site 405531006284 AMP binding site [chemical binding]; other site 405531006285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006286 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 405531006287 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531006288 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006289 acyl-activating enzyme (AAE) consensus motif; other site 405531006290 AMP binding site [chemical binding]; other site 405531006291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006292 MbtH-like protein; Region: MbtH; pfam03621 405531006293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006294 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531006295 putative substrate translocation pore; other site 405531006296 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405531006297 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405531006298 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405531006299 IHF dimer interface [polypeptide binding]; other site 405531006300 IHF - DNA interface [nucleotide binding]; other site 405531006301 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 405531006302 DinB family; Region: DinB; cl17821 405531006303 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405531006304 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 405531006305 active site 405531006306 catalytic triad [active] 405531006307 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531006308 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405531006309 Glycine riboswitch 405531006310 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405531006311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531006312 RNA binding surface [nucleotide binding]; other site 405531006313 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405531006314 probable active site [active] 405531006315 threonyl-tRNA synthetase; Reviewed; Region: PRK12444 405531006316 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405531006317 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405531006318 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405531006319 active site 405531006320 dimer interface [polypeptide binding]; other site 405531006321 motif 1; other site 405531006322 motif 2; other site 405531006323 motif 3; other site 405531006324 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405531006325 anticodon binding site; other site 405531006326 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531006327 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531006328 Walker A/P-loop; other site 405531006329 ATP binding site [chemical binding]; other site 405531006330 Q-loop/lid; other site 405531006331 ABC transporter signature motif; other site 405531006332 Walker B; other site 405531006333 D-loop; other site 405531006334 H-loop/switch region; other site 405531006335 FtsX-like permease family; Region: FtsX; pfam02687 405531006336 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 405531006337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531006338 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 405531006339 active site 405531006340 dimerization interface [polypeptide binding]; other site 405531006341 Protein of unknown function (DUF2441); Region: DUF2441; pfam10386 405531006342 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405531006343 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 405531006344 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405531006345 ligand binding site [chemical binding]; other site 405531006346 flexible hinge region; other site 405531006347 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405531006348 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405531006349 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 405531006350 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405531006351 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531006352 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531006353 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531006354 MMPL family; Region: MMPL; pfam03176 405531006355 MMPL family; Region: MMPL; pfam03176 405531006356 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 405531006357 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 405531006358 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 405531006359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006360 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531006361 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531006362 Coenzyme A binding pocket [chemical binding]; other site 405531006363 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531006364 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006365 Coenzyme A binding pocket [chemical binding]; other site 405531006366 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405531006367 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 405531006368 putative acetyltransferase YhhY; Provisional; Region: PRK10140 405531006369 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006370 Coenzyme A binding pocket [chemical binding]; other site 405531006371 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531006372 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405531006373 EamA-like transporter family; Region: EamA; pfam00892 405531006374 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405531006375 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531006376 non-specific DNA binding site [nucleotide binding]; other site 405531006377 salt bridge; other site 405531006378 sequence-specific DNA binding site [nucleotide binding]; other site 405531006379 Cupin domain; Region: Cupin_2; pfam07883 405531006380 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405531006381 protoporphyrinogen oxidase; Provisional; Region: PRK12416 405531006382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531006383 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531006384 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531006385 Cold-inducible protein YdjO; Region: YdjO; pfam14169 405531006386 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531006387 DNA-binding site [nucleotide binding]; DNA binding site 405531006388 RNA-binding motif; other site 405531006389 CAAX protease self-immunity; Region: Abi; pfam02517 405531006390 AAA domain; Region: AAA_17; pfam13207 405531006391 AAA domain; Region: AAA_18; pfam13238 405531006392 hypothetical protein; Provisional; Region: PRK06770 405531006393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531006394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531006395 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531006396 dimerization interface [polypeptide binding]; other site 405531006397 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK06728 405531006398 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405531006399 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405531006400 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 405531006401 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531006402 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531006403 dimerization interface [polypeptide binding]; other site 405531006404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405531006405 MOSC domain; Region: MOSC; pfam03473 405531006406 3-alpha domain; Region: 3-alpha; pfam03475 405531006407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006408 Coenzyme A binding pocket [chemical binding]; other site 405531006409 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 405531006410 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531006411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531006412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531006413 Walker A/P-loop; other site 405531006414 ATP binding site [chemical binding]; other site 405531006415 Q-loop/lid; other site 405531006416 ABC transporter signature motif; other site 405531006417 Walker B; other site 405531006418 D-loop; other site 405531006419 H-loop/switch region; other site 405531006420 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531006421 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531006422 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405531006423 Walker A/P-loop; other site 405531006424 ATP binding site [chemical binding]; other site 405531006425 Q-loop/lid; other site 405531006426 ABC transporter signature motif; other site 405531006427 Walker B; other site 405531006428 D-loop; other site 405531006429 H-loop/switch region; other site 405531006430 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405531006431 LysE type translocator; Region: LysE; cl00565 405531006432 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405531006433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531006434 non-specific DNA binding site [nucleotide binding]; other site 405531006435 salt bridge; other site 405531006436 sequence-specific DNA binding site [nucleotide binding]; other site 405531006437 Cupin domain; Region: Cupin_2; pfam07883 405531006438 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 405531006439 BclB C-terminal domain; Region: exospore_TM; TIGR03721 405531006440 Cupin; Region: Cupin_1; smart00835 405531006441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531006442 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 405531006443 potential frameshift: common BLAST hit: gi|49185294|ref|YP_028546.1| RNA polymerase sigma factor SigJ 405531006444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531006445 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 405531006446 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405531006447 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405531006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531006449 S-adenosylmethionine binding site [chemical binding]; other site 405531006450 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 405531006451 Domain of unknown function (DUF3974); Region: DUF3974; pfam13120 405531006452 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 405531006453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 405531006454 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405531006455 active site 405531006456 P-loop; other site 405531006457 phosphorylation site [posttranslational modification] 405531006458 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405531006459 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405531006460 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 405531006461 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 405531006462 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405531006463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 405531006464 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 405531006465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531006466 catalytic residue [active] 405531006467 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 405531006468 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405531006469 tetramer interface [polypeptide binding]; other site 405531006470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531006471 catalytic residue [active] 405531006472 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531006473 MarR family; Region: MarR; pfam01047 405531006474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531006476 putative substrate translocation pore; other site 405531006477 Uncharacterized conserved protein [Function unknown]; Region: COG3339 405531006478 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531006479 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 405531006480 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405531006481 ATP binding site [chemical binding]; other site 405531006482 Mg++ binding site [ion binding]; other site 405531006483 motif III; other site 405531006484 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531006485 nucleotide binding region [chemical binding]; other site 405531006486 ATP-binding site [chemical binding]; other site 405531006487 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531006488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531006489 S-adenosylmethionine binding site [chemical binding]; other site 405531006490 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405531006491 dimer interface [polypeptide binding]; other site 405531006492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531006493 S-adenosylmethionine binding site [chemical binding]; other site 405531006494 potential frameshift: common BLAST hit: gi|218230913|ref|YP_002367156.1| indolepyruvate decarboxylase 405531006495 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 405531006496 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 405531006497 TPP-binding site [chemical binding]; other site 405531006498 dimer interface [polypeptide binding]; other site 405531006499 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 405531006500 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531006501 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531006502 putative DNA binding site [nucleotide binding]; other site 405531006503 putative Zn2+ binding site [ion binding]; other site 405531006504 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531006505 catalytic core [active] 405531006506 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531006507 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 405531006508 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531006509 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 405531006510 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 405531006511 metal binding site [ion binding]; metal-binding site 405531006512 dimer interface [polypeptide binding]; other site 405531006513 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 405531006514 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531006515 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531006516 DNA binding residues [nucleotide binding] 405531006517 dimerization interface [polypeptide binding]; other site 405531006518 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531006519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531006520 non-specific DNA binding site [nucleotide binding]; other site 405531006521 salt bridge; other site 405531006522 sequence-specific DNA binding site [nucleotide binding]; other site 405531006523 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531006524 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405531006525 hypothetical protein; Provisional; Region: PRK10621 405531006526 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531006527 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405531006528 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405531006529 trimer interface [polypeptide binding]; other site 405531006530 active site 405531006531 substrate binding site [chemical binding]; other site 405531006532 CoA binding site [chemical binding]; other site 405531006533 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405531006534 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531006535 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405531006536 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 405531006537 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 405531006538 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 405531006539 active site 405531006540 catalytic triad [active] 405531006541 oxyanion hole [active] 405531006542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006543 putative substrate translocation pore; other site 405531006544 Condensation domain; Region: Condensation; pfam00668 405531006545 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531006546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531006547 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006548 acyl-activating enzyme (AAE) consensus motif; other site 405531006549 AMP binding site [chemical binding]; other site 405531006550 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006551 Condensation domain; Region: Condensation; pfam00668 405531006552 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531006553 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 405531006554 Condensation domain; Region: Condensation; pfam00668 405531006555 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531006556 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006557 acyl-activating enzyme (AAE) consensus motif; other site 405531006558 AMP binding site [chemical binding]; other site 405531006559 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006560 Condensation domain; Region: Condensation; pfam00668 405531006561 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531006562 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531006563 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 405531006564 acyl-activating enzyme (AAE) consensus motif; other site 405531006565 AMP binding site [chemical binding]; other site 405531006566 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006567 Condensation domain; Region: Condensation; pfam00668 405531006568 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531006569 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531006570 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006571 acyl-activating enzyme (AAE) consensus motif; other site 405531006572 AMP binding site [chemical binding]; other site 405531006573 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006574 peptide synthase; Provisional; Region: PRK12467 405531006575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531006576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006577 acyl-activating enzyme (AAE) consensus motif; other site 405531006578 AMP binding site [chemical binding]; other site 405531006579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006580 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 405531006581 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006582 acyl-activating enzyme (AAE) consensus motif; other site 405531006583 AMP binding site [chemical binding]; other site 405531006584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006585 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 405531006586 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531006587 acyl-activating enzyme (AAE) consensus motif; other site 405531006588 AMP binding site [chemical binding]; other site 405531006589 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531006590 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 405531006591 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405531006592 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405531006593 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 405531006594 short chain dehydrogenase; Provisional; Region: PRK12747 405531006595 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531006596 NAD(P) binding site [chemical binding]; other site 405531006597 active site 405531006598 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 405531006599 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503 405531006600 RNA ligase; Region: RNA_ligase; pfam09414 405531006601 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405531006602 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 405531006603 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405531006604 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405531006605 catalytic residue [active] 405531006606 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531006607 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531006608 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405531006609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006610 Coenzyme A binding pocket [chemical binding]; other site 405531006611 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 405531006612 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405531006613 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405531006614 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405531006615 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405531006616 inhibitor-cofactor binding pocket; inhibition site 405531006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531006618 catalytic residue [active] 405531006619 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531006620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531006621 NAD(P) binding site [chemical binding]; other site 405531006622 active site 405531006623 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405531006624 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405531006625 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531006626 catalytic residue [active] 405531006627 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 405531006628 WbqC-like protein family; Region: WbqC; pfam08889 405531006629 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 405531006630 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 405531006631 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405531006632 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 405531006633 PA/protease or protease-like domain interface [polypeptide binding]; other site 405531006634 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 405531006635 Peptidase family M28; Region: Peptidase_M28; pfam04389 405531006636 metal binding site [ion binding]; metal-binding site 405531006637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531006638 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531006639 putative substrate translocation pore; other site 405531006640 potential frameshift: common BLAST hit: gi|217956694|ref|YP_002335788.1| transcription factor, RsfA family 405531006641 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405531006642 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405531006643 S-layer homology domain; Region: SLH; pfam00395 405531006644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531006645 dimerization interface [polypeptide binding]; other site 405531006646 putative DNA binding site [nucleotide binding]; other site 405531006647 putative Zn2+ binding site [ion binding]; other site 405531006648 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405531006649 TPR motif; other site 405531006650 binding surface 405531006651 S-layer homology domain; Region: SLH; pfam00395 405531006652 S-layer homology domain; Region: SLH; pfam00395 405531006653 S-layer homology domain; Region: SLH; pfam00395 405531006654 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 405531006655 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 405531006656 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531006657 non-specific DNA binding site [nucleotide binding]; other site 405531006658 salt bridge; other site 405531006659 sequence-specific DNA binding site [nucleotide binding]; other site 405531006660 Cupin domain; Region: Cupin_2; pfam07883 405531006661 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 405531006662 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 405531006663 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531006664 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405531006665 NodB motif; other site 405531006666 active site 405531006667 catalytic site [active] 405531006668 Zn binding site [ion binding]; other site 405531006669 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 405531006670 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 405531006671 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531006672 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405531006673 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531006674 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405531006675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531006676 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531006677 DNA binding residues [nucleotide binding] 405531006678 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 405531006679 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531006680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531006681 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531006682 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531006683 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531006684 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531006685 beta-lactamase TEM; Provisional; Region: PRK15442 405531006686 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405531006687 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405531006688 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531006689 putative active site [active] 405531006690 putative metal binding site [ion binding]; other site 405531006691 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531006692 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405531006693 Walker A/P-loop; other site 405531006694 ATP binding site [chemical binding]; other site 405531006695 Q-loop/lid; other site 405531006696 ABC transporter signature motif; other site 405531006697 Walker B; other site 405531006698 D-loop; other site 405531006699 H-loop/switch region; other site 405531006700 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405531006701 ABC-2 type transporter; Region: ABC2_membrane; cl17235 405531006702 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531006703 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531006704 Protein of unknown function (DUF523); Region: DUF523; pfam04463 405531006705 Uncharacterized conserved protein [Function unknown]; Region: COG3272 405531006706 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 405531006707 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405531006708 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405531006709 FAD binding site [chemical binding]; other site 405531006710 homotetramer interface [polypeptide binding]; other site 405531006711 substrate binding pocket [chemical binding]; other site 405531006712 catalytic base [active] 405531006713 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 405531006714 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405531006715 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405531006716 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405531006717 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405531006718 carboxyltransferase (CT) interaction site; other site 405531006719 biotinylation site [posttranslational modification]; other site 405531006720 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 405531006721 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 405531006722 active site 405531006723 catalytic residues [active] 405531006724 metal binding site [ion binding]; metal-binding site 405531006725 enoyl-CoA hydratase; Provisional; Region: PRK07657 405531006726 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405531006727 substrate binding site [chemical binding]; other site 405531006728 oxyanion hole (OAH) forming residues; other site 405531006729 trimer interface [polypeptide binding]; other site 405531006730 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 405531006731 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405531006732 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 405531006733 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405531006734 acetate--CoA ligase; Region: Ac_CoA_lig_AcsA; TIGR02188 405531006735 Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; Region: AACS_like; cd05968 405531006736 acyl-activating enzyme (AAE) consensus motif; other site 405531006737 putative AMP binding site [chemical binding]; other site 405531006738 putative active site [active] 405531006739 putative CoA binding site [chemical binding]; other site 405531006740 putative transposase OrfB; Reviewed; Region: PHA02517 405531006741 HTH-like domain; Region: HTH_21; pfam13276 405531006742 Integrase core domain; Region: rve; pfam00665 405531006743 Integrase core domain; Region: rve_2; pfam13333 405531006744 Homeodomain-like domain; Region: HTH_23; cl17451 405531006745 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531006746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006747 Coenzyme A binding pocket [chemical binding]; other site 405531006748 Protein of unknown function (DUF3956); Region: DUF3956; pfam13104 405531006749 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405531006750 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531006751 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531006752 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531006753 dimer interface [polypeptide binding]; other site 405531006754 phosphorylation site [posttranslational modification] 405531006755 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531006756 ATP binding site [chemical binding]; other site 405531006757 Mg2+ binding site [ion binding]; other site 405531006758 G-X-G motif; other site 405531006759 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531006760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531006761 active site 405531006762 phosphorylation site [posttranslational modification] 405531006763 intermolecular recognition site; other site 405531006764 dimerization interface [polypeptide binding]; other site 405531006765 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531006766 DNA binding site [nucleotide binding] 405531006767 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531006768 Zn2+ binding site [ion binding]; other site 405531006769 Mg2+ binding site [ion binding]; other site 405531006770 Domain of unknown function (DUF3885); Region: DUF3885; pfam13021 405531006771 S-adenosylhomocysteine nucleosidase; Validated; Region: PRK06714 405531006772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531006773 Coenzyme A binding pocket [chemical binding]; other site 405531006774 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405531006775 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405531006776 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405531006777 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405531006778 active site 405531006779 Zn binding site [ion binding]; other site 405531006780 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405531006781 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 405531006782 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405531006783 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405531006784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531006785 Cna protein B-type domain; Region: Cna_B; pfam05738 405531006786 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 405531006787 Cna protein B-type domain; Region: Cna_B; pfam05738 405531006788 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405531006789 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 405531006790 active site 405531006791 catalytic site [active] 405531006792 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 405531006793 Cna protein B-type domain; Region: Cna_B; pfam05738 405531006794 Cna protein B-type domain; Region: Cna_B; pfam05738 405531006795 Cna protein B-type domain; Region: Cna_B; pfam05738 405531006796 Cna protein B-type domain; Region: Cna_B; pfam05738 405531006797 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405531006798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 405531006799 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 405531006800 putative hydrophobic ligand binding site [chemical binding]; other site 405531006801 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531006802 AAA domain; Region: AAA_21; pfam13304 405531006803 Walker A/P-loop; other site 405531006804 ATP binding site [chemical binding]; other site 405531006805 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531006806 ABC transporter signature motif; other site 405531006807 Walker B; other site 405531006808 D-loop; other site 405531006809 H-loop/switch region; other site 405531006810 ATP-binding cassette domain of the excision repair protein UvrA; Region: ABC_UvrA; cd03238 405531006811 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 405531006812 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 405531006813 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 405531006814 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531006815 DNA binding residues [nucleotide binding] 405531006816 drug binding residues [chemical binding]; other site 405531006817 dimer interface [polypeptide binding]; other site 405531006818 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405531006819 short chain dehydrogenase; Provisional; Region: PRK07041 405531006820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531006821 NAD(P) binding site [chemical binding]; other site 405531006822 active site 405531006823 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531006824 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405531006825 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405531006826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531006827 S-adenosylmethionine binding site [chemical binding]; other site 405531006828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531006829 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531006830 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405531006831 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531006832 active site 405531006833 Phosphotransferase enzyme family; Region: APH; pfam01636 405531006834 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405531006835 active site 405531006836 substrate binding site [chemical binding]; other site 405531006837 ATP binding site [chemical binding]; other site 405531006838 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531006839 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531006840 active site 405531006841 ATP binding site [chemical binding]; other site 405531006842 substrate binding site [chemical binding]; other site 405531006843 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 405531006844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531006845 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 405531006846 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 405531006847 active site 405531006848 Zn binding site [ion binding]; other site 405531006849 Protein of unknown function (DUF4030); Region: DUF4030; pfam13222 405531006850 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531006851 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531006852 DNA-binding site [nucleotide binding]; DNA binding site 405531006853 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531006854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531006855 homodimer interface [polypeptide binding]; other site 405531006856 catalytic residue [active] 405531006857 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 405531006858 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405531006859 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405531006860 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 405531006861 putative NAD(P) binding site [chemical binding]; other site 405531006862 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531006863 Predicted membrane protein [Function unknown]; Region: COG2323 405531006864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531006865 S-adenosylmethionine binding site [chemical binding]; other site 405531006866 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531006867 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 405531006868 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405531006869 conserved cys residue [active] 405531006870 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405531006871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531006872 S-adenosylmethionine binding site [chemical binding]; other site 405531006873 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 405531006874 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 405531006875 catalytic core domain of class I lysyl tRNA synthetase; Region: LysRS_core_class_I; cd00674 405531006876 active site 405531006877 HIGH motif; other site 405531006878 KMSKS motif; other site 405531006879 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405531006880 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 405531006881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531006882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531006883 active site 405531006884 phosphorylation site [posttranslational modification] 405531006885 intermolecular recognition site; other site 405531006886 dimerization interface [polypeptide binding]; other site 405531006887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531006888 DNA binding site [nucleotide binding] 405531006889 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531006890 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405531006891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531006892 ATP binding site [chemical binding]; other site 405531006893 Mg2+ binding site [ion binding]; other site 405531006894 G-X-G motif; other site 405531006895 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 405531006896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531006897 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 405531006898 dimerization interface [polypeptide binding]; other site 405531006899 substrate binding pocket [chemical binding]; other site 405531006900 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531006901 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531006902 active site 405531006903 catalytic tetrad [active] 405531006904 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531006905 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531006906 ABC transporter; Region: ABC_tran_2; pfam12848 405531006907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531006908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531006909 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531006910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531006911 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531006912 Walker A/P-loop; other site 405531006913 ATP binding site [chemical binding]; other site 405531006914 Q-loop/lid; other site 405531006915 ABC transporter signature motif; other site 405531006916 Walker B; other site 405531006917 D-loop; other site 405531006918 H-loop/switch region; other site 405531006919 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531006920 FtsX-like permease family; Region: FtsX; pfam02687 405531006921 hypothetical protein; Provisional; Region: PRK06760 405531006922 Protein of unknown function (DUF3914); Region: DUF3914; pfam13053 405531006923 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 405531006924 homoserine dehydrogenase; Validated; Region: PRK06813 405531006925 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405531006926 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531006927 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531006928 DNA-binding site [nucleotide binding]; DNA binding site 405531006929 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531006930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531006931 homodimer interface [polypeptide binding]; other site 405531006932 catalytic residue [active] 405531006933 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 405531006934 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405531006935 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405531006936 Putative transcription activator [Transcription]; Region: TenA; COG0819 405531006937 Protein of unknown function (DUF3937); Region: DUF3937; pfam13073 405531006938 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405531006939 Protein of unknown function (DUF3962); Region: DUF3962; pfam13111 405531006940 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405531006941 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 405531006942 Int/Topo IB signature motif; other site 405531006943 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531006944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531006945 non-specific DNA binding site [nucleotide binding]; other site 405531006946 salt bridge; other site 405531006947 sequence-specific DNA binding site [nucleotide binding]; other site 405531006948 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405531006949 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405531006950 Probable transposase; Region: OrfB_IS605; pfam01385 405531006951 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531006952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 405531006953 salt bridge; other site 405531006954 Helix-turn-helix domain; Region: HTH_17; pfam12728 405531006955 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 405531006956 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405531006957 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405531006958 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405531006959 dUTPase; Region: dUTPase_2; pfam08761 405531006960 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 405531006961 active site 405531006962 homodimer interface [polypeptide binding]; other site 405531006963 metal binding site [ion binding]; metal-binding site 405531006964 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 405531006965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405531006966 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405531006967 Probable transposase; Region: OrfB_IS605; pfam01385 405531006968 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531006969 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405531006970 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 405531006971 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 405531006972 Probable transposase; Region: OrfB_IS605; pfam01385 405531006973 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531006974 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405531006975 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405531006976 Int/Topo IB signature motif; other site 405531006977 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 405531006978 biotin/lipoate protein ligase; Provisional; Region: PTZ00276 405531006979 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 405531006980 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 405531006981 HNH endonuclease; Region: HNH; pfam01844 405531006982 active site 405531006983 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 405531006984 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405531006985 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 405531006986 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405531006987 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405531006988 oligomer interface [polypeptide binding]; other site 405531006989 active site residues [active] 405531006990 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405531006991 Phage capsid family; Region: Phage_capsid; pfam05065 405531006992 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405531006993 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405531006994 Phage-related minor tail protein [Function unknown]; Region: COG5280 405531006995 Group I catalytic intron 405531006996 Phage-related protein [Function unknown]; Region: COG5412 405531006997 Phage-related minor tail protein [Function unknown]; Region: COG5281 405531006998 Phage tail protein; Region: Sipho_tail; pfam05709 405531006999 Phage tail protein; Region: Sipho_tail; cl17486 405531007000 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405531007001 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 405531007002 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405531007003 Holin family; Region: Phage_holin_4; pfam05105 405531007004 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: COG5632 405531007005 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531007006 amidase catalytic site [active] 405531007007 Zn binding residues [ion binding]; other site 405531007008 substrate binding site [chemical binding]; other site 405531007009 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 405531007010 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531007011 Domain of unknown function (DUF3893); Region: DUF3893; pfam13032 405531007012 Protein of unknown function (DUF3959); Region: DUF3959; pfam13105 405531007013 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 405531007014 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 405531007015 Protein of unknown function; Region: DUF3658; pfam12395 405531007016 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405531007017 Cytochrome P450; Region: p450; cl12078 405531007018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007019 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531007020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007021 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405531007022 trimer interface [polypeptide binding]; other site 405531007023 active site 405531007024 substrate binding site [chemical binding]; other site 405531007025 CoA binding site [chemical binding]; other site 405531007026 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 405531007027 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531007028 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531007029 Cytochrome P450; Region: p450; cl12078 405531007030 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405531007031 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 405531007032 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531007033 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531007034 active site 405531007035 motif I; other site 405531007036 motif II; other site 405531007037 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405531007038 PAS domain S-box; Region: sensory_box; TIGR00229 405531007039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531007040 putative active site [active] 405531007041 heme pocket [chemical binding]; other site 405531007042 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405531007043 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531007044 dimer interface [polypeptide binding]; other site 405531007045 phosphorylation site [posttranslational modification] 405531007046 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531007047 ATP binding site [chemical binding]; other site 405531007048 Mg2+ binding site [ion binding]; other site 405531007049 G-X-G motif; other site 405531007050 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531007051 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531007052 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531007053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531007054 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531007055 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531007056 Catalytic site [active] 405531007057 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405531007058 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405531007059 active site 405531007060 TDP-binding site; other site 405531007061 acceptor substrate-binding pocket; other site 405531007062 homodimer interface [polypeptide binding]; other site 405531007063 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 405531007064 aspartate racemase; Region: asp_race; TIGR00035 405531007065 hypothetical protein; Provisional; Region: PRK13661 405531007066 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 405531007067 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405531007068 Walker A/P-loop; other site 405531007069 ATP binding site [chemical binding]; other site 405531007070 Q-loop/lid; other site 405531007071 ABC transporter signature motif; other site 405531007072 Walker B; other site 405531007073 D-loop; other site 405531007074 H-loop/switch region; other site 405531007075 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 405531007076 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405531007077 Walker A/P-loop; other site 405531007078 ATP binding site [chemical binding]; other site 405531007079 Q-loop/lid; other site 405531007080 ABC transporter signature motif; other site 405531007081 Walker B; other site 405531007082 D-loop; other site 405531007083 H-loop/switch region; other site 405531007084 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405531007085 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405531007086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531007087 dimer interface [polypeptide binding]; other site 405531007088 phosphorylation site [posttranslational modification] 405531007089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531007090 ATP binding site [chemical binding]; other site 405531007091 Mg2+ binding site [ion binding]; other site 405531007092 G-X-G motif; other site 405531007093 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 405531007094 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 405531007095 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405531007096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531007097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531007098 putative transporter; Provisional; Region: PRK11021 405531007099 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405531007100 nudix motif; other site 405531007101 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 405531007102 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405531007103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405531007104 active site 405531007105 ATP binding site [chemical binding]; other site 405531007106 substrate binding site [chemical binding]; other site 405531007107 activation loop (A-loop); other site 405531007108 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405531007109 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405531007110 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405531007111 NAD(P) binding site [chemical binding]; other site 405531007112 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405531007113 active site 405531007114 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405531007115 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531007116 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531007117 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531007118 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405531007119 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405531007120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007121 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531007122 putative substrate translocation pore; other site 405531007123 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531007124 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531007125 VanZ like family; Region: VanZ; pfam04892 405531007126 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 405531007127 EDD domain protein, DegV family; Region: DegV; TIGR00762 405531007128 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405531007129 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405531007130 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531007131 DNA binding residues [nucleotide binding] 405531007132 Trm112p-like protein; Region: Trm112p; pfam03966 405531007133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531007134 S-adenosylmethionine binding site [chemical binding]; other site 405531007135 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531007136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007138 Coenzyme A binding pocket [chemical binding]; other site 405531007139 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405531007140 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405531007141 active site 405531007142 catalytic site [active] 405531007143 metal binding site [ion binding]; metal-binding site 405531007144 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 405531007145 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531007146 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531007147 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 405531007148 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531007149 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531007150 DNA-binding site [nucleotide binding]; DNA binding site 405531007151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531007152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531007153 homodimer interface [polypeptide binding]; other site 405531007154 catalytic residue [active] 405531007155 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531007156 EamA-like transporter family; Region: EamA; pfam00892 405531007157 EamA-like transporter family; Region: EamA; pfam00892 405531007158 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 405531007159 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405531007160 active site 405531007161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007162 Coenzyme A binding pocket [chemical binding]; other site 405531007163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405531007164 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_30; cd04689 405531007165 nudix motif; other site 405531007166 probable heterocycle-containing bacteriocin, BA_2677 family; Region: B_an_ocin; TIGR03601 405531007167 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531007168 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531007169 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405531007170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007171 putative substrate translocation pore; other site 405531007172 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531007173 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007174 Coenzyme A binding pocket [chemical binding]; other site 405531007175 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405531007176 nudix motif; other site 405531007177 DNA polymerase III subunit beta; Validated; Region: PRK06673 405531007178 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405531007179 putative DNA binding surface [nucleotide binding]; other site 405531007180 dimer interface [polypeptide binding]; other site 405531007181 beta-clamp/clamp loader binding surface; other site 405531007182 beta-clamp/translesion DNA polymerase binding surface; other site 405531007183 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405531007184 nudix motif; other site 405531007185 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405531007186 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 405531007187 translation initiation factor IF-2; Provisional; Region: PRK14845 405531007188 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405531007189 homotrimer interaction site [polypeptide binding]; other site 405531007190 putative active site [active] 405531007191 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 405531007192 potential frameshift: common BLAST hit: gi|52142805|ref|YP_084024.1| esterase 405531007193 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 405531007194 YxiJ-like protein; Region: YxiJ; pfam14176 405531007195 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405531007196 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405531007197 active site 405531007198 nucleophile elbow; other site 405531007199 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405531007200 pentamer interface [polypeptide binding]; other site 405531007201 dodecaamer interface [polypeptide binding]; other site 405531007202 potential frameshift: common BLAST hit: gi|217960155|ref|YP_002338715.1| GNAT family acetyltransferase 405531007203 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531007204 Coenzyme A binding pocket [chemical binding]; other site 405531007205 metal-dependent hydrolase; Provisional; Region: PRK13291 405531007206 DinB superfamily; Region: DinB_2; pfam12867 405531007207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531007208 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531007209 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 405531007210 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405531007211 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405531007212 GIY-YIG motif/motif A; other site 405531007213 active site 405531007214 catalytic site [active] 405531007215 putative DNA binding site [nucleotide binding]; other site 405531007216 metal binding site [ion binding]; metal-binding site 405531007217 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531007218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007219 Coenzyme A binding pocket [chemical binding]; other site 405531007220 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 405531007221 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405531007222 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531007223 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531007224 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405531007225 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405531007226 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405531007227 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 405531007228 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405531007229 active site 405531007230 ATP binding site [chemical binding]; other site 405531007231 substrate binding site [chemical binding]; other site 405531007232 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 405531007233 nudix motif; other site 405531007234 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405531007235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531007236 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 405531007237 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 405531007238 MepB protein; Region: MepB; pfam08877 405531007239 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 405531007240 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 405531007241 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531007242 motif II; other site 405531007243 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 405531007244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531007245 active site 405531007246 phosphorylation site [posttranslational modification] 405531007247 intermolecular recognition site; other site 405531007248 dimerization interface [polypeptide binding]; other site 405531007249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531007250 DNA binding site [nucleotide binding] 405531007251 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405531007252 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531007253 dimerization interface [polypeptide binding]; other site 405531007254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531007255 dimer interface [polypeptide binding]; other site 405531007256 phosphorylation site [posttranslational modification] 405531007257 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531007258 ATP binding site [chemical binding]; other site 405531007259 Mg2+ binding site [ion binding]; other site 405531007260 G-X-G motif; other site 405531007261 DinB superfamily; Region: DinB_2; pfam12867 405531007262 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405531007263 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531007264 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531007265 Walker A/P-loop; other site 405531007266 ATP binding site [chemical binding]; other site 405531007267 Q-loop/lid; other site 405531007268 ABC transporter signature motif; other site 405531007269 Walker B; other site 405531007270 D-loop; other site 405531007271 H-loop/switch region; other site 405531007272 FtsX-like permease family; Region: FtsX; pfam02687 405531007273 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531007274 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405531007275 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405531007276 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531007277 tyrosine decarboxylase; Region: PLN02880 405531007278 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 405531007279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531007280 catalytic residue [active] 405531007281 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405531007282 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 405531007283 acyl-activating enzyme (AAE) consensus motif; other site 405531007284 AMP binding site [chemical binding]; other site 405531007285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531007286 Condensation domain; Region: Condensation; pfam00668 405531007287 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531007288 Nonribosomal peptide synthase; Region: NRPS; pfam08415 405531007289 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 405531007290 acyl-activating enzyme (AAE) consensus motif; other site 405531007291 AMP binding site [chemical binding]; other site 405531007292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405531007293 Condensation domain; Region: Condensation; pfam00668 405531007294 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405531007295 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 405531007296 putative FMN binding site [chemical binding]; other site 405531007297 NADPH bind site [chemical binding]; other site 405531007298 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 405531007299 carbohydrate binding site [chemical binding]; other site 405531007300 pullulanase, type I; Region: pulA_typeI; TIGR02104 405531007301 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405531007302 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405531007303 Ca binding site [ion binding]; other site 405531007304 active site 405531007305 catalytic site [active] 405531007306 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405531007307 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405531007308 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405531007309 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405531007310 active site 405531007311 Zn binding site [ion binding]; other site 405531007312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405531007313 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405531007314 active site 405531007315 metal binding site [ion binding]; metal-binding site 405531007316 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405531007317 DinB superfamily; Region: DinB_2; pfam12867 405531007318 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 405531007319 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 405531007320 putative metal binding site [ion binding]; other site 405531007321 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531007322 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12907 405531007323 SecY translocase; Region: SecY; pfam00344 405531007324 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 405531007325 EamA-like transporter family; Region: EamA; pfam00892 405531007326 EamA-like transporter family; Region: EamA; pfam00892 405531007327 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531007328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531007329 DNA-binding site [nucleotide binding]; DNA binding site 405531007330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531007331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531007332 homodimer interface [polypeptide binding]; other site 405531007333 catalytic residue [active] 405531007334 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531007335 TAP-like protein; Region: Abhydrolase_4; pfam08386 405531007336 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405531007337 Mg binding site [ion binding]; other site 405531007338 nucleotide binding site [chemical binding]; other site 405531007339 putative protofilament interface [polypeptide binding]; other site 405531007340 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 405531007341 Predicted membrane protein [Function unknown]; Region: COG4129 405531007342 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405531007343 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531007344 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 405531007345 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405531007346 germination protein YpeB; Region: spore_YpeB; TIGR02889 405531007347 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 405531007348 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405531007349 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405531007350 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 405531007351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531007352 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531007353 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 405531007354 arylformamidase; Region: trp_arylform; TIGR03035 405531007355 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405531007356 kynureninase; Region: kynureninase; TIGR01814 405531007357 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531007358 catalytic residue [active] 405531007359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531007360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531007361 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405531007362 nudix motif; other site 405531007363 Protein of unknown function (DUF3977); Region: DUF3977; pfam13122 405531007364 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 405531007365 GAF domain; Region: GAF; pfam01590 405531007366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531007367 Walker A motif; other site 405531007368 ATP binding site [chemical binding]; other site 405531007369 Walker B motif; other site 405531007370 arginine finger; other site 405531007371 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405531007372 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405531007373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007374 Coenzyme A binding pocket [chemical binding]; other site 405531007375 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405531007376 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405531007377 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405531007378 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531007379 S-adenosylmethionine binding site [chemical binding]; other site 405531007380 Rrf2 family protein; Region: rrf2_super; TIGR00738 405531007381 Transcriptional regulator; Region: Rrf2; pfam02082 405531007382 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 405531007383 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 405531007384 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531007385 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531007386 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405531007387 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405531007388 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405531007389 E3 interaction surface; other site 405531007390 lipoyl attachment site [posttranslational modification]; other site 405531007391 e3 binding domain; Region: E3_binding; pfam02817 405531007392 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405531007393 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405531007394 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405531007395 alpha subunit interface [polypeptide binding]; other site 405531007396 TPP binding site [chemical binding]; other site 405531007397 heterodimer interface [polypeptide binding]; other site 405531007398 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405531007399 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405531007400 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405531007401 tetramer interface [polypeptide binding]; other site 405531007402 TPP-binding site [chemical binding]; other site 405531007403 heterodimer interface [polypeptide binding]; other site 405531007404 phosphorylation loop region [posttranslational modification] 405531007405 DinB superfamily; Region: DinB_2; pfam12867 405531007406 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 405531007407 short chain dehydrogenase; Provisional; Region: PRK06914 405531007408 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 405531007409 NADP binding site [chemical binding]; other site 405531007410 active site 405531007411 steroid binding site; other site 405531007412 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405531007413 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405531007414 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405531007415 nudix motif; other site 405531007416 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 405531007417 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405531007418 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 405531007419 nucleotide binding site/active site [active] 405531007420 HIT family signature motif; other site 405531007421 catalytic residue [active] 405531007422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531007423 dimer interface [polypeptide binding]; other site 405531007424 conserved gate region; other site 405531007425 putative PBP binding loops; other site 405531007426 ABC-ATPase subunit interface; other site 405531007427 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 405531007428 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 405531007429 Walker A/P-loop; other site 405531007430 ATP binding site [chemical binding]; other site 405531007431 Q-loop/lid; other site 405531007432 ABC transporter signature motif; other site 405531007433 Walker B; other site 405531007434 D-loop; other site 405531007435 H-loop/switch region; other site 405531007436 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 405531007437 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 405531007438 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405531007439 Clp protease; Region: CLP_protease; pfam00574 405531007440 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405531007441 oligomer interface [polypeptide binding]; other site 405531007442 active site residues [active] 405531007443 RNA polymerase factor sigma-70; Validated; Region: PRK06704 405531007444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531007445 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 405531007446 DNA binding residues [nucleotide binding] 405531007447 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405531007448 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405531007449 catalytic loop [active] 405531007450 iron binding site [ion binding]; other site 405531007451 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 405531007452 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531007453 active site 405531007454 dimer interface [polypeptide binding]; other site 405531007455 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 405531007456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007457 Coenzyme A binding pocket [chemical binding]; other site 405531007458 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405531007459 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531007460 Interdomain contacts; other site 405531007461 Cytokine receptor motif; other site 405531007462 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 405531007463 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531007464 Interdomain contacts; other site 405531007465 Cytokine receptor motif; other site 405531007466 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 405531007467 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405531007468 glycosyltransferase, MGT family; Region: MGT; TIGR01426 405531007469 active site 405531007470 TDP-binding site; other site 405531007471 acceptor substrate-binding pocket; other site 405531007472 homodimer interface [polypeptide binding]; other site 405531007473 Uncharacterized conserved protein [Function unknown]; Region: COG1262 405531007474 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 405531007475 topology modulation protein; Reviewed; Region: PRK08118 405531007476 AAA domain; Region: AAA_17; pfam13207 405531007477 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531007478 active site 405531007479 ATP binding site [chemical binding]; other site 405531007480 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 405531007481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531007482 S-adenosylmethionine binding site [chemical binding]; other site 405531007483 Protein of unknown function (DUF419); Region: DUF419; pfam04237 405531007484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007485 Coenzyme A binding pocket [chemical binding]; other site 405531007486 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007487 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531007488 Coenzyme A binding pocket [chemical binding]; other site 405531007489 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405531007490 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405531007491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007492 Coenzyme A binding pocket [chemical binding]; other site 405531007493 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531007494 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531007495 Protein of unknown function (DUF952); Region: DUF952; pfam06108 405531007496 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007497 Coenzyme A binding pocket [chemical binding]; other site 405531007498 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 405531007499 Part of AAA domain; Region: AAA_19; pfam13245 405531007500 Family description; Region: UvrD_C_2; pfam13538 405531007501 Methyltransferase domain; Region: Methyltransf_18; pfam12847 405531007502 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 405531007503 putative active site pocket [active] 405531007504 dimerization interface [polypeptide binding]; other site 405531007505 putative catalytic residue [active] 405531007506 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 405531007507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531007508 ATP binding site [chemical binding]; other site 405531007509 putative Mg++ binding site [ion binding]; other site 405531007510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531007511 nucleotide binding region [chemical binding]; other site 405531007512 ATP-binding site [chemical binding]; other site 405531007513 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 405531007514 HRDC domain; Region: HRDC; pfam00570 405531007515 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405531007516 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405531007517 active site 405531007518 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405531007519 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405531007520 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405531007521 active site 405531007522 metal binding site [ion binding]; metal-binding site 405531007523 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405531007524 Protein of unknown function (DUF4017); Region: DUF4017; pfam13209 405531007525 potential frameshift: common BLAST hit: gi|42781910|ref|NP_979157.1| peptidase M3 family protein 405531007526 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405531007527 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405531007528 Zn binding site [ion binding]; other site 405531007529 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 405531007530 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 405531007531 DHHA2 domain; Region: DHHA2; pfam02833 405531007532 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405531007533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531007534 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007535 Coenzyme A binding pocket [chemical binding]; other site 405531007536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531007537 Zn2+ binding site [ion binding]; other site 405531007538 Mg2+ binding site [ion binding]; other site 405531007539 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 405531007540 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531007541 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 405531007542 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405531007543 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405531007544 NAD(P) binding site [chemical binding]; other site 405531007545 catalytic residues [active] 405531007546 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 405531007547 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 405531007548 inhibitor site; inhibition site 405531007549 active site 405531007550 dimer interface [polypeptide binding]; other site 405531007551 catalytic residue [active] 405531007552 Proline racemase; Region: Pro_racemase; pfam05544 405531007553 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405531007554 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405531007555 Proline racemase; Region: Pro_racemase; pfam05544 405531007556 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 405531007557 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405531007558 PAS domain; Region: PAS_10; pfam13596 405531007559 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 405531007560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531007561 Walker A motif; other site 405531007562 ATP binding site [chemical binding]; other site 405531007563 Walker B motif; other site 405531007564 arginine finger; other site 405531007565 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405531007566 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405531007567 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405531007568 catalytic loop [active] 405531007569 iron binding site [ion binding]; other site 405531007570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 405531007571 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405531007572 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 405531007573 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405531007574 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405531007575 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531007576 Zn2+ binding site [ion binding]; other site 405531007577 Mg2+ binding site [ion binding]; other site 405531007578 Region found in RelA / SpoT proteins; Region: RelA_SpoT; smart00954 405531007579 metal binding triad [ion binding]; metal-binding site 405531007580 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405531007581 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405531007582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531007583 Zn2+ binding site [ion binding]; other site 405531007584 Mg2+ binding site [ion binding]; other site 405531007585 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531007586 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531007587 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 405531007588 DltD N-terminal region; Region: DltD_N; pfam04915 405531007589 DltD central region; Region: DltD_M; pfam04918 405531007590 DltD C-terminal region; Region: DltD_C; pfam04914 405531007591 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531007592 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531007593 peptide binding site [polypeptide binding]; other site 405531007594 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405531007595 NlpC/P60 family; Region: NLPC_P60; pfam00877 405531007596 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405531007597 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405531007598 active site 405531007599 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 405531007600 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405531007601 Septum formation initiator; Region: DivIC; pfam04977 405531007602 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531007603 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531007604 active site 405531007605 catalytic tetrad [active] 405531007606 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405531007607 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 405531007608 conserved cys residue [active] 405531007609 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 405531007610 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405531007611 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405531007612 AAA domain; Region: AAA_17; pfam13207 405531007613 AAA domain; Region: AAA_18; pfam13238 405531007614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531007615 S-adenosylmethionine binding site [chemical binding]; other site 405531007616 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 405531007617 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405531007618 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405531007619 catalytic residues [active] 405531007620 catalytic nucleophile [active] 405531007621 Recombinase; Region: Recombinase; pfam07508 405531007622 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405531007623 Replication-relaxation; Region: Replic_Relax; pfam13814 405531007624 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405531007625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531007626 non-specific DNA binding site [nucleotide binding]; other site 405531007627 salt bridge; other site 405531007628 sequence-specific DNA binding site [nucleotide binding]; other site 405531007629 Domain of unknown function (DUF3961); Region: DUF3961; pfam13106 405531007630 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531007631 non-specific DNA binding site [nucleotide binding]; other site 405531007632 salt bridge; other site 405531007633 sequence-specific DNA binding site [nucleotide binding]; other site 405531007634 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 405531007635 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531007636 amidase catalytic site [active] 405531007637 Zn binding residues [ion binding]; other site 405531007638 substrate binding site [chemical binding]; other site 405531007639 Haemolysin XhlA; Region: XhlA; pfam10779 405531007640 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405531007641 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405531007642 Phage tail protein; Region: Sipho_tail; pfam05709 405531007643 Phage tail protein; Region: Sipho_tail; cl17486 405531007644 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405531007645 Phage-related protein [Function unknown]; Region: COG5412 405531007646 Phage protein; Region: DUF3647; pfam12363 405531007647 phage major tail protein, TP901-1 family; Region: phgtail_TP901_1; TIGR02126 405531007648 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 405531007649 Head fiber protein; Region: Phage_head_fibr; pfam11133 405531007650 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 405531007651 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 405531007652 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 405531007653 Helix-turn-helix of insertion element transposase; Region: HTH_Tnp_1_2; pfam13022 405531007654 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 405531007655 active site 405531007656 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405531007657 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 405531007658 hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564 405531007659 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 405531007660 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 405531007661 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405531007662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531007663 dimerization interface [polypeptide binding]; other site 405531007664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531007665 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531007666 dimer interface [polypeptide binding]; other site 405531007667 phosphorylation site [posttranslational modification] 405531007668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531007669 ATP binding site [chemical binding]; other site 405531007670 Mg2+ binding site [ion binding]; other site 405531007671 G-X-G motif; other site 405531007672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531007673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531007674 active site 405531007675 phosphorylation site [posttranslational modification] 405531007676 intermolecular recognition site; other site 405531007677 dimerization interface [polypeptide binding]; other site 405531007678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531007679 DNA binding site [nucleotide binding] 405531007680 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Validated; Region: PRK06698 405531007681 bifunctional 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase/phosphatase; Provisional; Region: PRK14697 405531007682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531007683 motif II; other site 405531007684 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405531007685 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405531007686 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405531007687 Zn binding site [ion binding]; other site 405531007688 EDD domain protein, DegV family; Region: DegV; TIGR00762 405531007689 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405531007690 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405531007691 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405531007692 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 405531007693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405531007694 Coenzyme A binding pocket [chemical binding]; other site 405531007695 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 405531007696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531007698 putative substrate translocation pore; other site 405531007699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007700 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 405531007701 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 405531007702 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 405531007703 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405531007704 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405531007705 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405531007706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531007708 putative substrate translocation pore; other site 405531007709 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 405531007710 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 405531007711 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405531007712 active site 405531007713 Protein of unknown function (DUF3970); Region: DUF3970; pfam13113 405531007714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531007715 S-adenosylmethionine binding site [chemical binding]; other site 405531007716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007717 putative substrate translocation pore; other site 405531007718 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531007719 aspartate aminotransferase; Provisional; Region: PRK07681 405531007720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531007721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531007722 homodimer interface [polypeptide binding]; other site 405531007723 catalytic residue [active] 405531007724 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405531007725 pantothenate kinase; Provisional; Region: PRK13317 405531007726 pantothenate kinase, eukaryotic/staphyloccocal type; Region: panK_eukar; TIGR00555 405531007727 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 405531007728 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405531007729 Protein of unknown function (DUF4052); Region: DUF4052; pfam13261 405531007730 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531007731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531007732 Walker A/P-loop; other site 405531007733 ATP binding site [chemical binding]; other site 405531007734 Q-loop/lid; other site 405531007735 ABC transporter signature motif; other site 405531007736 Walker B; other site 405531007737 D-loop; other site 405531007738 H-loop/switch region; other site 405531007739 Predicted transcriptional regulators [Transcription]; Region: COG1725 405531007740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531007741 DNA-binding site [nucleotide binding]; DNA binding site 405531007742 DinB family; Region: DinB; cl17821 405531007743 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405531007744 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405531007745 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405531007746 Bacillus tandem small hypothetical protein; Region: Bac_small_yrzI; TIGR02413 405531007747 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 405531007748 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405531007749 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405531007750 HNH endonuclease; Region: HNH_5; pfam14279 405531007751 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 405531007752 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 405531007753 active site 405531007754 dimer interface [polypeptide binding]; other site 405531007755 non-prolyl cis peptide bond; other site 405531007756 insertion regions; other site 405531007757 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405531007758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405531007759 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 405531007760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531007761 substrate binding pocket [chemical binding]; other site 405531007762 membrane-bound complex binding site; other site 405531007763 hinge residues; other site 405531007764 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405531007765 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405531007766 Walker A/P-loop; other site 405531007767 ATP binding site [chemical binding]; other site 405531007768 Q-loop/lid; other site 405531007769 ABC transporter signature motif; other site 405531007770 Walker B; other site 405531007771 D-loop; other site 405531007772 H-loop/switch region; other site 405531007773 Protein of unknown function (DUF402); Region: DUF402; pfam04167 405531007774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405531007775 binding surface 405531007776 TPR motif; other site 405531007777 hypothetical protein; Provisional; Region: PRK09620 405531007778 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 405531007779 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 405531007780 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531007781 Coenzyme A binding pocket [chemical binding]; other site 405531007782 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405531007783 DinB superfamily; Region: DinB_2; pfam12867 405531007784 Protein of unknown function (DUF664); Region: DUF664; pfam04978 405531007785 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 405531007786 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007787 Coenzyme A binding pocket [chemical binding]; other site 405531007788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531007789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531007790 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405531007791 active site 405531007792 NTP binding site [chemical binding]; other site 405531007793 metal binding triad [ion binding]; metal-binding site 405531007794 antibiotic binding site [chemical binding]; other site 405531007795 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405531007796 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405531007797 active site 405531007798 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405531007799 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 405531007800 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531007801 catalytic residue [active] 405531007802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531007803 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531007804 active site 405531007805 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531007806 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531007807 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405531007808 NodB motif; other site 405531007809 active site 405531007810 catalytic site [active] 405531007811 Zn binding site [ion binding]; other site 405531007812 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531007813 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531007814 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405531007815 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 405531007816 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405531007817 Sulfatase; Region: Sulfatase; pfam00884 405531007818 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 405531007819 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531007820 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531007821 ABC transporter; Region: ABC_tran_2; pfam12848 405531007822 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531007823 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 405531007824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531007825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531007826 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 405531007827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007828 Coenzyme A binding pocket [chemical binding]; other site 405531007829 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 405531007830 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 405531007831 hinge; other site 405531007832 active site 405531007833 prephenate dehydrogenase; Validated; Region: PRK06545 405531007834 prephenate dehydrogenase; Validated; Region: PRK08507 405531007835 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 405531007836 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 405531007837 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531007838 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531007839 homodimer interface [polypeptide binding]; other site 405531007840 catalytic residue [active] 405531007841 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405531007842 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405531007843 Tetramer interface [polypeptide binding]; other site 405531007844 active site 405531007845 FMN-binding site [chemical binding]; other site 405531007846 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 405531007847 Chorismate mutase type II; Region: CM_2; cl00693 405531007848 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 405531007849 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 405531007850 Domain of unknown function (DUF4020); Region: DUF4020; pfam13212 405531007851 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405531007852 Isochorismatase family; Region: Isochorismatase; pfam00857 405531007853 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405531007854 catalytic triad [active] 405531007855 conserved cis-peptide bond; other site 405531007856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531007857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531007859 Coenzyme A binding pocket [chemical binding]; other site 405531007860 YfzA-like protein; Region: YfzA; pfam14118 405531007861 hypothetical protein; Provisional; Region: PRK06762 405531007862 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531007863 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531007864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405531007865 Mediator complex subunit Med5; Region: Med5; pfam08689 405531007866 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 405531007867 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 405531007868 malate:quinone oxidoreductase; Validated; Region: PRK05257 405531007869 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 405531007870 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 405531007871 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 405531007872 ligand binding site [chemical binding]; other site 405531007873 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405531007874 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405531007875 TM-ABC transporter signature motif; other site 405531007876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405531007877 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405531007878 TM-ABC transporter signature motif; other site 405531007879 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405531007880 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405531007881 Walker A/P-loop; other site 405531007882 ATP binding site [chemical binding]; other site 405531007883 Q-loop/lid; other site 405531007884 ABC transporter signature motif; other site 405531007885 Walker B; other site 405531007886 D-loop; other site 405531007887 H-loop/switch region; other site 405531007888 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405531007889 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405531007890 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405531007891 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 405531007892 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 405531007893 putative N- and C-terminal domain interface [polypeptide binding]; other site 405531007894 putative active site [active] 405531007895 putative MgATP binding site [chemical binding]; other site 405531007896 catalytic site [active] 405531007897 metal binding site [ion binding]; metal-binding site 405531007898 putative carbohydrate binding site [chemical binding]; other site 405531007899 Cupin domain; Region: Cupin_2; pfam07883 405531007900 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 405531007901 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 405531007902 putative active site; other site 405531007903 catalytic residue [active] 405531007904 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531007905 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531007906 active site 405531007907 metal binding site [ion binding]; metal-binding site 405531007908 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 405531007909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007910 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531007911 putative substrate translocation pore; other site 405531007912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531007913 putative DNA binding site [nucleotide binding]; other site 405531007914 putative Zn2+ binding site [ion binding]; other site 405531007915 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405531007916 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405531007917 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405531007918 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 405531007919 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 405531007920 putative catalytic cysteine [active] 405531007921 gamma-glutamyl kinase; Provisional; Region: PRK05429 405531007922 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 405531007923 nucleotide binding site [chemical binding]; other site 405531007924 homotetrameric interface [polypeptide binding]; other site 405531007925 putative phosphate binding site [ion binding]; other site 405531007926 putative allosteric binding site; other site 405531007927 PUA domain; Region: PUA; pfam01472 405531007928 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK12491 405531007929 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405531007930 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 405531007931 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 405531007932 putative metal binding site [ion binding]; other site 405531007933 putative dimer interface [polypeptide binding]; other site 405531007934 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405531007935 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405531007936 Bacterial transcriptional regulator; Region: IclR; pfam01614 405531007937 S-methylmethionine transporter; Provisional; Region: PRK11387 405531007938 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531007939 active site 405531007940 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531007941 active site 405531007942 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 405531007943 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 405531007944 putative di-iron ligands [ion binding]; other site 405531007945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 405531007946 Immune inhibitor A peptidase M6; Region: Peptidase_M6; pfam05547 405531007947 VanW like protein; Region: VanW; pfam04294 405531007948 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405531007949 dimer interface [polypeptide binding]; other site 405531007950 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405531007951 active site 405531007952 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 405531007953 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531007954 salt bridge; other site 405531007955 non-specific DNA binding site [nucleotide binding]; other site 405531007956 sequence-specific DNA binding site [nucleotide binding]; other site 405531007957 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 405531007958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531007959 motif II; other site 405531007960 uridine kinase; Provisional; Region: PRK07667 405531007961 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531007962 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531007963 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531007964 Coenzyme A binding pocket [chemical binding]; other site 405531007965 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531007966 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531007967 active site 405531007968 metal binding site [ion binding]; metal-binding site 405531007969 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 405531007970 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531007971 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405531007972 MoxR-like ATPases [General function prediction only]; Region: COG0714 405531007973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531007974 Walker A motif; other site 405531007975 ATP binding site [chemical binding]; other site 405531007976 Walker B motif; other site 405531007977 arginine finger; other site 405531007978 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 405531007979 Protein of unknown function DUF58; Region: DUF58; pfam01882 405531007980 Domain of unknown function (DUF4018); Region: DUF4018; pfam13210 405531007981 hypothetical protein; Provisional; Region: PRK06761 405531007982 proline/glycine betaine transporter; Provisional; Region: PRK10642 405531007983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531007984 putative substrate translocation pore; other site 405531007985 acetylornithine aminotransferase; Provisional; Region: PRK02627 405531007986 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531007987 inhibitor-cofactor binding pocket; inhibition site 405531007988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531007989 catalytic residue [active] 405531007990 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 405531007991 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 405531007992 tetramer interface [polypeptide binding]; other site 405531007993 heme binding pocket [chemical binding]; other site 405531007994 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 405531007995 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405531007996 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 405531007997 active site 405531007998 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 405531007999 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531008000 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531008001 Protein of unknown function (DUF3902); Region: DUF3902; pfam13042 405531008002 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 405531008003 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 405531008004 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 405531008005 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 405531008006 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 405531008007 LXG domain of WXG superfamily; Region: LXG; pfam04740 405531008008 Protein of unknown function (DUF3958); Region: DUF3958; pfam13125 405531008009 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 405531008010 Uncharacterized conserved protein [Function unknown]; Region: COG1359 405531008011 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405531008012 dimer interface [polypeptide binding]; other site 405531008013 FMN binding site [chemical binding]; other site 405531008014 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531008015 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008016 putative DNA binding site [nucleotide binding]; other site 405531008017 putative Zn2+ binding site [ion binding]; other site 405531008018 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 405531008019 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 405531008020 G1 box; other site 405531008021 putative GEF interaction site [polypeptide binding]; other site 405531008022 GTP/Mg2+ binding site [chemical binding]; other site 405531008023 Switch I region; other site 405531008024 G2 box; other site 405531008025 G3 box; other site 405531008026 Switch II region; other site 405531008027 G4 box; other site 405531008028 G5 box; other site 405531008029 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 405531008030 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 405531008031 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 405531008032 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405531008033 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405531008034 nudix motif; other site 405531008035 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 405531008036 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 405531008037 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 405531008038 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405531008039 putative NAD(P) binding site [chemical binding]; other site 405531008040 active site 405531008041 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531008042 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531008043 Walker A/P-loop; other site 405531008044 ATP binding site [chemical binding]; other site 405531008045 Q-loop/lid; other site 405531008046 ABC transporter signature motif; other site 405531008047 Walker B; other site 405531008048 D-loop; other site 405531008049 H-loop/switch region; other site 405531008050 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405531008051 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531008052 FtsX-like permease family; Region: FtsX; pfam02687 405531008053 FtsX-like permease family; Region: FtsX; pfam02687 405531008054 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 405531008055 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531008056 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531008057 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405531008058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531008059 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 405531008060 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405531008061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008062 Coenzyme A binding pocket [chemical binding]; other site 405531008063 Domain of unknown function (DUF3980); Region: DUF3980; pfam13140 405531008064 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 405531008065 nudix motif; other site 405531008066 EamA-like transporter family; Region: EamA; pfam00892 405531008067 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531008068 EamA-like transporter family; Region: EamA; pfam00892 405531008069 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531008070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531008071 DNA-binding site [nucleotide binding]; DNA binding site 405531008072 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531008073 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531008074 homodimer interface [polypeptide binding]; other site 405531008075 catalytic residue [active] 405531008076 hypothetical protein; Validated; Region: PRK00124 405531008077 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 405531008078 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405531008079 uridine kinase; Validated; Region: PRK06696 405531008080 AAA domain; Region: AAA_18; pfam13238 405531008081 active site 405531008082 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 405531008083 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531008084 active site 405531008085 metal binding site [ion binding]; metal-binding site 405531008086 Phosphotransferase enzyme family; Region: APH; pfam01636 405531008087 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531008088 active site 405531008089 substrate binding site [chemical binding]; other site 405531008090 ATP binding site [chemical binding]; other site 405531008091 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 405531008092 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531008093 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531008094 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531008095 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531008096 Lysine riboswitch 405531008097 lysine transporter; Provisional; Region: PRK10836 405531008098 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 405531008099 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 405531008100 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405531008101 Cytochrome P450; Region: p450; cl12078 405531008102 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405531008103 active site 405531008104 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 405531008105 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405531008106 Transcription factor Tfb2; Region: Tfb2; cl04289 405531008107 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 405531008108 homodimer interface [polypeptide binding]; other site 405531008109 putative substrate binding pocket [chemical binding]; other site 405531008110 diiron center [ion binding]; other site 405531008111 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008112 ATP binding site [chemical binding]; other site 405531008113 G-X-G motif; other site 405531008114 Methyltransferase domain; Region: Methyltransf_11; pfam08241 405531008115 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405531008116 putative active site [active] 405531008117 nucleotide binding site [chemical binding]; other site 405531008118 nudix motif; other site 405531008119 putative metal binding site [ion binding]; other site 405531008120 Cephalosporin hydroxylase; Region: CmcI; pfam04989 405531008121 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531008122 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531008123 Catalytic site [active] 405531008124 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531008125 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531008126 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531008127 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531008128 NAD-dependent deacetylase; Provisional; Region: PRK00481 405531008129 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 405531008130 NAD+ binding site [chemical binding]; other site 405531008131 substrate binding site [chemical binding]; other site 405531008132 Zn binding site [ion binding]; other site 405531008133 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 405531008134 putative substrate binding pocket [chemical binding]; other site 405531008135 AC domain interface; other site 405531008136 catalytic triad [active] 405531008137 AB domain interface; other site 405531008138 interchain disulfide; other site 405531008139 Predicted membrane protein [Function unknown]; Region: COG3817 405531008140 Protein of unknown function (DUF979); Region: DUF979; pfam06166 405531008141 Protein of unknown function (DUF969); Region: DUF969; pfam06149 405531008142 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 405531008143 putative active site [active] 405531008144 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 405531008145 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 405531008146 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 405531008147 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405531008148 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405531008149 Bacterial transcriptional regulator; Region: IclR; pfam01614 405531008150 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531008151 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531008152 Catalytic site [active] 405531008153 CutC family; Region: CutC; cl01218 405531008154 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008155 dimerization interface [polypeptide binding]; other site 405531008156 putative DNA binding site [nucleotide binding]; other site 405531008157 putative Zn2+ binding site [ion binding]; other site 405531008158 DinB superfamily; Region: DinB_2; pfam12867 405531008159 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405531008160 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405531008161 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 405531008162 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405531008163 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405531008164 putative active site [active] 405531008165 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531008166 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531008167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 405531008168 Nucleoside recognition; Region: Gate; pfam07670 405531008169 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 405531008170 Phosphotransferase enzyme family; Region: APH; pfam01636 405531008171 putative active site [active] 405531008172 putative substrate binding site [chemical binding]; other site 405531008173 ATP binding site [chemical binding]; other site 405531008174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008175 Coenzyme A binding pocket [chemical binding]; other site 405531008176 Protein of unknown function (DUF2691); Region: DUF2691; pfam10903 405531008177 Uncharacterized conserved protein [Function unknown]; Region: COG1633 405531008178 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 405531008179 dinuclear metal binding motif [ion binding]; other site 405531008180 Domain of unknown function (DUF2610); Region: DUF2610; pfam11020 405531008181 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531008182 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531008183 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405531008184 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405531008185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531008186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531008187 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405531008188 phosphoenolpyruvate synthase; Validated; Region: PRK06241 405531008189 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 405531008190 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405531008191 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531008192 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 405531008193 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 405531008194 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531008195 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 405531008196 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405531008197 NAD binding site [chemical binding]; other site 405531008198 catalytic Zn binding site [ion binding]; other site 405531008199 structural Zn binding site [ion binding]; other site 405531008200 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 405531008201 dimanganese center [ion binding]; other site 405531008202 aspartate ammonia-lyase; Provisional; Region: PRK14515 405531008203 Aspartase; Region: Aspartase; cd01357 405531008204 active sites [active] 405531008205 tetramer interface [polypeptide binding]; other site 405531008206 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 405531008207 active site 405531008208 homodimer interface [polypeptide binding]; other site 405531008209 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531008210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531008211 non-specific DNA binding site [nucleotide binding]; other site 405531008212 salt bridge; other site 405531008213 sequence-specific DNA binding site [nucleotide binding]; other site 405531008214 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405531008215 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531008216 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531008217 Spore germination protein; Region: Spore_permease; pfam03845 405531008218 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531008219 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405531008220 PAS fold; Region: PAS_4; pfam08448 405531008221 PAS domain S-box; Region: sensory_box; TIGR00229 405531008222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531008223 putative active site [active] 405531008224 heme pocket [chemical binding]; other site 405531008225 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405531008226 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531008227 putative active site [active] 405531008228 heme pocket [chemical binding]; other site 405531008229 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531008230 dimer interface [polypeptide binding]; other site 405531008231 phosphorylation site [posttranslational modification] 405531008232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008233 ATP binding site [chemical binding]; other site 405531008234 Mg2+ binding site [ion binding]; other site 405531008235 G-X-G motif; other site 405531008236 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531008237 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531008238 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531008239 Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791 405531008240 potential frameshift: common BLAST hit: gi|118478439|ref|YP_895590.1| AraC family transcriptional regulator 405531008241 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531008242 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405531008243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531008244 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405531008245 GIY-YIG motif/motif A; other site 405531008246 active site 405531008247 catalytic site [active] 405531008248 putative DNA binding site [nucleotide binding]; other site 405531008249 metal binding site [ion binding]; metal-binding site 405531008250 amino acid transporter; Region: 2A0306; TIGR00909 405531008251 Spore germination protein; Region: Spore_permease; cl17796 405531008252 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 405531008253 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405531008254 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405531008255 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531008256 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531008257 Spore germination protein; Region: Spore_permease; pfam03845 405531008258 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531008259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531008260 Response regulator receiver domain; Region: Response_reg; pfam00072 405531008261 active site 405531008262 phosphorylation site [posttranslational modification] 405531008263 intermolecular recognition site; other site 405531008264 dimerization interface [polypeptide binding]; other site 405531008265 YcbB domain; Region: YcbB; pfam08664 405531008266 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531008267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008268 ATP binding site [chemical binding]; other site 405531008269 Mg2+ binding site [ion binding]; other site 405531008270 G-X-G motif; other site 405531008271 glutaminase; Reviewed; Region: PRK12357 405531008272 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405531008273 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531008274 amino acid carrier protein; Region: agcS; TIGR00835 405531008275 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 405531008276 transmembrane helices; other site 405531008277 Cytochrome P450; Region: p450; cl12078 405531008278 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531008279 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531008280 Erythromycin esterase; Region: Erythro_esteras; cl17110 405531008281 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405531008282 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405531008283 putative active site [active] 405531008284 putative metal binding site [ion binding]; other site 405531008285 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405531008286 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531008287 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531008288 TAP-like protein; Region: Abhydrolase_4; pfam08386 405531008289 Isochorismatase family; Region: Isochorismatase; pfam00857 405531008290 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405531008291 catalytic triad [active] 405531008292 dimer interface [polypeptide binding]; other site 405531008293 conserved cis-peptide bond; other site 405531008294 Isochorismatase family; Region: Isochorismatase; pfam00857 405531008295 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405531008296 catalytic triad [active] 405531008297 dimer interface [polypeptide binding]; other site 405531008298 conserved cis-peptide bond; other site 405531008299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 405531008300 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405531008301 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405531008302 active site 405531008303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405531008304 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531008305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531008306 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531008307 dimerization interface [polypeptide binding]; other site 405531008308 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531008309 MarR family; Region: MarR; pfam01047 405531008310 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 405531008311 Cl binding site [ion binding]; other site 405531008312 oligomer interface [polypeptide binding]; other site 405531008313 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405531008314 plasmid segregation protein ParM; Provisional; Region: PRK13917 405531008315 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405531008316 Mg binding site [ion binding]; other site 405531008317 nucleotide binding site [chemical binding]; other site 405531008318 putative protofilament interface [polypeptide binding]; other site 405531008319 Heat induced stress protein YflT; Region: YflT; pfam11181 405531008320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531008321 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405531008322 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531008323 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 405531008324 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405531008325 TspO/MBR family; Region: TspO_MBR; pfam03073 405531008326 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 405531008327 DNA photolyase; Region: DNA_photolyase; pfam00875 405531008328 Carbonic anhydrase; Region: Pro_CA; pfam00484 405531008329 zinc binding site [ion binding]; other site 405531008330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 405531008331 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 405531008332 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 405531008333 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405531008334 Uncharacterized conserved protein (DUF2294); Region: DUF2294; pfam10057 405531008335 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531008336 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405531008337 NodB motif; other site 405531008338 active site 405531008339 catalytic site [active] 405531008340 Zn binding site [ion binding]; other site 405531008341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531008342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008343 Coenzyme A binding pocket [chemical binding]; other site 405531008344 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Provisional; Region: PRK13387 405531008345 UbiA prenyltransferase family; Region: UbiA; pfam01040 405531008346 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 405531008347 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 405531008348 metal binding site [ion binding]; metal-binding site 405531008349 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405531008350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531008351 ABC-ATPase subunit interface; other site 405531008352 dimer interface [polypeptide binding]; other site 405531008353 putative PBP binding regions; other site 405531008354 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405531008355 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405531008356 DJ-1 family protein; Region: not_thiJ; TIGR01383 405531008357 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 405531008358 conserved cys residue [active] 405531008359 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405531008360 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405531008361 active site 405531008362 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 405531008363 arsenical-resistance protein; Region: acr3; TIGR00832 405531008364 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531008365 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 405531008366 putative metal binding site [ion binding]; other site 405531008367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008368 dimerization interface [polypeptide binding]; other site 405531008369 putative DNA binding site [nucleotide binding]; other site 405531008370 putative Zn2+ binding site [ion binding]; other site 405531008371 Putative amidotransferase; Region: DUF4066; pfam13278 405531008372 conserved cys residue [active] 405531008373 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531008374 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531008375 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405531008376 putative dimerization interface [polypeptide binding]; other site 405531008377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008378 putative substrate translocation pore; other site 405531008379 D-galactonate transporter; Region: 2A0114; TIGR00893 405531008380 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531008381 EamA-like transporter family; Region: EamA; pfam00892 405531008382 EamA-like transporter family; Region: EamA; pfam00892 405531008383 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531008384 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405531008385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405531008386 DinB superfamily; Region: DinB_2; pfam12867 405531008387 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 405531008388 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405531008389 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405531008390 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 405531008391 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405531008392 putative NAD(P) binding site [chemical binding]; other site 405531008393 active site 405531008394 putative substrate binding site [chemical binding]; other site 405531008395 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531008396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531008397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531008398 short chain dehydrogenase; Provisional; Region: PRK12746 405531008399 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 405531008400 NADP binding site [chemical binding]; other site 405531008401 homodimer interface [polypeptide binding]; other site 405531008402 active site 405531008403 substrate binding site [chemical binding]; other site 405531008404 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405531008405 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008406 putative DNA binding site [nucleotide binding]; other site 405531008407 putative Zn2+ binding site [ion binding]; other site 405531008408 AsnC family; Region: AsnC_trans_reg; pfam01037 405531008409 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 405531008410 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405531008411 metal binding site [ion binding]; metal-binding site 405531008412 AAA domain; Region: AAA_11; pfam13086 405531008413 Part of AAA domain; Region: AAA_19; pfam13245 405531008414 AAA domain; Region: AAA_30; pfam13604 405531008415 AAA domain; Region: AAA_12; pfam13087 405531008416 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405531008417 putative active site [active] 405531008418 catalytic site [active] 405531008419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531008420 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531008421 active site 405531008422 metal binding site [ion binding]; metal-binding site 405531008423 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531008424 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531008425 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 405531008426 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405531008427 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 405531008428 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531008429 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531008430 active site 405531008431 phosphorylation site [posttranslational modification] 405531008432 intermolecular recognition site; other site 405531008433 dimerization interface [polypeptide binding]; other site 405531008434 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531008435 DNA binding site [nucleotide binding] 405531008436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531008437 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531008438 dimerization interface [polypeptide binding]; other site 405531008439 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531008440 dimer interface [polypeptide binding]; other site 405531008441 phosphorylation site [posttranslational modification] 405531008442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008443 ATP binding site [chemical binding]; other site 405531008444 G-X-G motif; other site 405531008445 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 405531008446 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405531008447 CAAX protease self-immunity; Region: Abi; pfam02517 405531008448 Erythromycin esterase; Region: Erythro_esteras; pfam05139 405531008449 Putative sensor; Region: Sensor; pfam13796 405531008450 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531008451 Histidine kinase; Region: HisKA_3; pfam07730 405531008452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008453 ATP binding site [chemical binding]; other site 405531008454 Mg2+ binding site [ion binding]; other site 405531008455 G-X-G motif; other site 405531008456 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531008457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531008458 active site 405531008459 phosphorylation site [posttranslational modification] 405531008460 intermolecular recognition site; other site 405531008461 dimerization interface [polypeptide binding]; other site 405531008462 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531008463 DNA binding residues [nucleotide binding] 405531008464 dimerization interface [polypeptide binding]; other site 405531008465 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405531008466 FAD binding domain; Region: FAD_binding_4; pfam01565 405531008467 Berberine and berberine like; Region: BBE; pfam08031 405531008468 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531008469 FtsX-like permease family; Region: FtsX; pfam02687 405531008470 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531008471 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531008472 Walker A/P-loop; other site 405531008473 ATP binding site [chemical binding]; other site 405531008474 Q-loop/lid; other site 405531008475 ABC transporter signature motif; other site 405531008476 Walker B; other site 405531008477 D-loop; other site 405531008478 H-loop/switch region; other site 405531008479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531008480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531008481 dimer interface [polypeptide binding]; other site 405531008482 phosphorylation site [posttranslational modification] 405531008483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008484 ATP binding site [chemical binding]; other site 405531008485 Mg2+ binding site [ion binding]; other site 405531008486 G-X-G motif; other site 405531008487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531008488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531008489 active site 405531008490 phosphorylation site [posttranslational modification] 405531008491 intermolecular recognition site; other site 405531008492 dimerization interface [polypeptide binding]; other site 405531008493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531008494 DNA binding site [nucleotide binding] 405531008495 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 405531008496 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405531008497 putative metal binding site [ion binding]; other site 405531008498 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 405531008499 Cytochrome P450; Region: p450; pfam00067 405531008500 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 405531008501 Flavodoxin; Region: Flavodoxin_1; pfam00258 405531008502 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 405531008503 FAD binding pocket [chemical binding]; other site 405531008504 FAD binding motif [chemical binding]; other site 405531008505 catalytic residues [active] 405531008506 NAD binding pocket [chemical binding]; other site 405531008507 phosphate binding motif [ion binding]; other site 405531008508 beta-alpha-beta structure motif; other site 405531008509 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405531008510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008511 putative substrate translocation pore; other site 405531008512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008513 D-cysteine desulfhydrase; Validated; Region: PRK03910 405531008514 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 405531008515 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531008516 catalytic residue [active] 405531008517 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405531008518 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531008519 active site 405531008520 metal binding site [ion binding]; metal-binding site 405531008521 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 405531008522 Protein of unknown function (DUF975); Region: DUF975; cl10504 405531008523 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 405531008524 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 405531008525 AAA domain; Region: AAA_33; pfam13671 405531008526 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405531008527 active site 405531008528 Fibrinogen alpha/beta chain family; Region: Fib_alpha; pfam08702 405531008529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531008530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531008531 Walker A/P-loop; other site 405531008532 ATP binding site [chemical binding]; other site 405531008533 Q-loop/lid; other site 405531008534 ABC transporter signature motif; other site 405531008535 Walker B; other site 405531008536 D-loop; other site 405531008537 H-loop/switch region; other site 405531008538 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405531008539 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531008540 FtsX-like permease family; Region: FtsX; pfam02687 405531008541 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 405531008542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531008543 dimerization interface [polypeptide binding]; other site 405531008544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531008545 dimer interface [polypeptide binding]; other site 405531008546 phosphorylation site [posttranslational modification] 405531008547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531008548 ATP binding site [chemical binding]; other site 405531008549 Mg2+ binding site [ion binding]; other site 405531008550 G-X-G motif; other site 405531008551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531008552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531008553 active site 405531008554 phosphorylation site [posttranslational modification] 405531008555 intermolecular recognition site; other site 405531008556 dimerization interface [polypeptide binding]; other site 405531008557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531008558 DNA binding site [nucleotide binding] 405531008559 Predicted membrane protein [Function unknown]; Region: COG2364 405531008560 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405531008561 MarR family; Region: MarR; pfam01047 405531008562 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 405531008563 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008564 Coenzyme A binding pocket [chemical binding]; other site 405531008565 Transcriptional regulator [Transcription]; Region: PaiB; COG2808 405531008566 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531008567 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531008568 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531008569 F0F1 ATP synthase subunit alpha; Validated; Region: PRK06763 405531008570 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405531008571 putative dimer interface [polypeptide binding]; other site 405531008572 catalytic triad [active] 405531008573 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 405531008574 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405531008575 active site 1 [active] 405531008576 Uncharacterized conserved protein [Function unknown]; Region: COG4198 405531008577 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 405531008578 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 405531008579 glyoxylate reductase; Reviewed; Region: PRK13243 405531008580 putative ligand binding site [chemical binding]; other site 405531008581 putative NAD binding site [chemical binding]; other site 405531008582 putative catalytic site [active] 405531008583 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 405531008584 L-serine binding site [chemical binding]; other site 405531008585 ACT domain interface; other site 405531008586 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 405531008587 homodimer interface [polypeptide binding]; other site 405531008588 substrate-cofactor binding pocket; other site 405531008589 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531008590 catalytic residue [active] 405531008591 Uncharacterized conserved protein [Function unknown]; Region: COG2155 405531008592 Cupin domain; Region: Cupin_2; cl17218 405531008593 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 405531008594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531008595 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 405531008596 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 405531008597 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 405531008598 active site 405531008599 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 405531008600 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405531008601 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531008602 substrate binding site [chemical binding]; other site 405531008603 amidase catalytic site [active] 405531008604 Zn binding residues [ion binding]; other site 405531008605 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531008606 S-layer homology domain; Region: SLH; pfam00395 405531008607 S-layer homology domain; Region: SLH; pfam00395 405531008608 S-layer homology domain; Region: SLH; pfam00395 405531008609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531008610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531008611 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405531008612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008613 putative substrate translocation pore; other site 405531008614 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 405531008615 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 405531008616 Protein of unknown function, DUF600; Region: DUF600; pfam04634 405531008617 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405531008618 A new structural DNA glycosylase; Region: AlkD_like; cd06561 405531008619 active site 405531008620 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 405531008621 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 405531008622 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 405531008623 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 405531008624 potential frameshift: common BLAST hit: gi|218233595|ref|YP_002367992.1| SMI1 / KNR4 family 405531008625 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405531008626 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 405531008627 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 405531008628 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 405531008629 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 405531008630 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405531008631 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 405531008632 Protein of unknown function, DUF600; Region: DUF600; pfam04634 405531008633 A short region before toxin nuclease domain; Region: NUC_N; pfam14448 405531008634 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 405531008635 Protein of unknown function, DUF600; Region: DUF600; pfam04634 405531008636 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 405531008637 Transposase; Region: DEDD_Tnp_IS110; pfam01548 405531008638 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 405531008639 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405531008640 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405531008641 catalytic residues [active] 405531008642 catalytic nucleophile [active] 405531008643 Recombinase; Region: Recombinase; pfam07508 405531008644 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 405531008645 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 405531008646 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405531008647 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405531008648 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 405531008649 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 405531008650 putative active site [active] 405531008651 putative metal binding site [ion binding]; other site 405531008652 NETI protein; Region: NETI; pfam14044 405531008653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008654 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531008655 putative substrate translocation pore; other site 405531008656 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531008657 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531008658 TAP-like protein; Region: Abhydrolase_4; pfam08386 405531008659 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531008660 MarR family; Region: MarR_2; pfam12802 405531008661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531008662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008663 putative substrate translocation pore; other site 405531008664 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531008665 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531008666 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 405531008667 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405531008668 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405531008669 SWIM zinc finger; Region: SWIM; pfam04434 405531008670 YwiC-like protein; Region: YwiC; pfam14256 405531008671 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 405531008672 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405531008673 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405531008674 Walker A/P-loop; other site 405531008675 ATP binding site [chemical binding]; other site 405531008676 Q-loop/lid; other site 405531008677 ABC transporter signature motif; other site 405531008678 Walker B; other site 405531008679 D-loop; other site 405531008680 H-loop/switch region; other site 405531008681 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405531008682 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 405531008683 Walker A/P-loop; other site 405531008684 ATP binding site [chemical binding]; other site 405531008685 Q-loop/lid; other site 405531008686 ABC transporter signature motif; other site 405531008687 Walker B; other site 405531008688 D-loop; other site 405531008689 H-loop/switch region; other site 405531008690 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405531008691 potential frameshift: common BLAST hit: gi|218231857|ref|YP_002368025.1| lpxtg-motif cell wall anchor domain protein 405531008692 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 405531008693 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 405531008694 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 405531008695 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 405531008696 Predicted membrane protein [Function unknown]; Region: COG1288 405531008697 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 405531008698 Endonuclease I; Region: Endonuclease_1; pfam04231 405531008699 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 405531008700 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405531008701 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 405531008702 putative deacylase active site [active] 405531008703 histidyl-tRNA synthetase; Provisional; Region: PRK12420 405531008704 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405531008705 dimer interface [polypeptide binding]; other site 405531008706 motif 1; other site 405531008707 active site 405531008708 motif 2; other site 405531008709 motif 3; other site 405531008710 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405531008711 anticodon binding site; other site 405531008712 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531008713 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405531008714 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 405531008715 dimer interface [polypeptide binding]; other site 405531008716 FMN binding site [chemical binding]; other site 405531008717 pyruvate kinase; Validated; Region: PRK06739 405531008718 active site 405531008719 domain interfaces; other site 405531008720 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 405531008721 classical (c) SDRs; Region: SDR_c; cd05233 405531008722 NAD(P) binding site [chemical binding]; other site 405531008723 active site 405531008724 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405531008725 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531008726 Walker A/P-loop; other site 405531008727 ATP binding site [chemical binding]; other site 405531008728 Q-loop/lid; other site 405531008729 ABC transporter signature motif; other site 405531008730 Walker B; other site 405531008731 D-loop; other site 405531008732 H-loop/switch region; other site 405531008733 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 405531008734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531008735 non-specific DNA binding site [nucleotide binding]; other site 405531008736 salt bridge; other site 405531008737 sequence-specific DNA binding site [nucleotide binding]; other site 405531008738 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405531008739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531008740 motif II; other site 405531008741 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 405531008742 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 405531008743 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 405531008744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008745 Coenzyme A binding pocket [chemical binding]; other site 405531008746 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405531008747 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405531008748 nudix motif; other site 405531008749 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 405531008750 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 405531008751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531008752 putative metal binding site [ion binding]; other site 405531008753 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405531008754 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405531008755 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 405531008756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008757 putative substrate translocation pore; other site 405531008758 maltose O-acetyltransferase; Provisional; Region: PRK10092 405531008759 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405531008760 active site 405531008761 substrate binding site [chemical binding]; other site 405531008762 trimer interface [polypeptide binding]; other site 405531008763 CoA binding site [chemical binding]; other site 405531008764 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405531008765 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405531008766 active site 405531008767 HIGH motif; other site 405531008768 dimer interface [polypeptide binding]; other site 405531008769 KMSKS motif; other site 405531008770 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK12464 405531008771 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405531008772 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405531008773 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405531008774 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405531008775 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405531008776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008777 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531008778 Coenzyme A binding pocket [chemical binding]; other site 405531008779 ydaO/yuaA leader 405531008780 potential frameshift: common BLAST hit: gi|217960770|ref|YP_002339334.1| ubiquinone/menaquinone biosynthesis methyltransferase ubie 405531008781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405531008782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531008783 S-adenosylmethionine binding site [chemical binding]; other site 405531008784 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 405531008785 CGNR zinc finger; Region: zf-CGNR; pfam11706 405531008786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008787 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531008788 putative substrate translocation pore; other site 405531008789 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405531008790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531008791 TPR motif; other site 405531008792 binding surface 405531008793 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405531008794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531008795 binding surface 405531008796 TPR motif; other site 405531008797 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 405531008798 hypothetical protein; Provisional; Region: PRK04164 405531008799 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531008800 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405531008801 Domain of unknown function DUF21; Region: DUF21; pfam01595 405531008802 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405531008803 Transporter associated domain; Region: CorC_HlyC; smart01091 405531008804 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 405531008805 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531008806 DNA binding residues [nucleotide binding] 405531008807 putative dimer interface [polypeptide binding]; other site 405531008808 EamA-like transporter family; Region: EamA; pfam00892 405531008809 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531008810 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 405531008811 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 405531008812 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 405531008813 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 405531008814 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 405531008815 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 405531008816 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 405531008817 N- and C-terminal domain interface [polypeptide binding]; other site 405531008818 active site 405531008819 catalytic site [active] 405531008820 metal binding site [ion binding]; metal-binding site 405531008821 carbohydrate binding site [chemical binding]; other site 405531008822 ATP binding site [chemical binding]; other site 405531008823 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405531008824 active site 405531008825 intersubunit interactions; other site 405531008826 catalytic residue [active] 405531008827 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 405531008828 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405531008829 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405531008830 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405531008831 TPP-binding site [chemical binding]; other site 405531008832 dimer interface [polypeptide binding]; other site 405531008833 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405531008834 PYR/PP interface [polypeptide binding]; other site 405531008835 dimer interface [polypeptide binding]; other site 405531008836 TPP binding site [chemical binding]; other site 405531008837 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 405531008838 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405531008839 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 405531008840 hypothetical protein; Provisional; Region: PRK02487 405531008841 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 405531008842 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405531008843 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 405531008844 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405531008845 A short protein domain of unknown function; Region: IDEAL; smart00914 405531008846 Transcriptional regulator; Region: Rrf2; pfam02082 405531008847 Rrf2 family protein; Region: rrf2_super; TIGR00738 405531008848 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 405531008849 ArsC family; Region: ArsC; pfam03960 405531008850 putative catalytic residues [active] 405531008851 thiol/disulfide switch; other site 405531008852 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531008853 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008854 dimerization interface [polypeptide binding]; other site 405531008855 putative DNA binding site [nucleotide binding]; other site 405531008856 putative Zn2+ binding site [ion binding]; other site 405531008857 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405531008858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531008859 DNA-binding site [nucleotide binding]; DNA binding site 405531008860 UTRA domain; Region: UTRA; pfam07702 405531008861 putative oxidoreductase; Provisional; Region: PRK10206 405531008862 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405531008863 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405531008864 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 405531008865 putative hydrophobic ligand binding site [chemical binding]; other site 405531008866 protein interface [polypeptide binding]; other site 405531008867 gate; other site 405531008868 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 405531008869 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 405531008870 putative active site [active] 405531008871 putative catalytic triad [active] 405531008872 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 405531008873 catalytic triad [active] 405531008874 oxyanion hole [active] 405531008875 active site 405531008876 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531008877 Phosphotransferase enzyme family; Region: APH; pfam01636 405531008878 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531008879 substrate binding site [chemical binding]; other site 405531008880 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405531008881 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405531008882 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 405531008883 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 405531008884 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531008885 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531008886 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 405531008887 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405531008888 acyl-activating enzyme (AAE) consensus motif; other site 405531008889 AMP binding site [chemical binding]; other site 405531008890 active site 405531008891 CoA binding site [chemical binding]; other site 405531008892 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 405531008893 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531008894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008895 dimerization interface [polypeptide binding]; other site 405531008896 putative DNA binding site [nucleotide binding]; other site 405531008897 putative Zn2+ binding site [ion binding]; other site 405531008898 hypothetical protein; Provisional; Region: PRK08244 405531008899 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405531008900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531008901 dimerization interface [polypeptide binding]; other site 405531008902 putative DNA binding site [nucleotide binding]; other site 405531008903 putative Zn2+ binding site [ion binding]; other site 405531008904 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 405531008905 active site 405531008906 Glyco_18 domain; Region: Glyco_18; smart00636 405531008907 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 405531008908 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 405531008909 NodB motif; other site 405531008910 putative active site [active] 405531008911 putative catalytic site [active] 405531008912 putative Zn binding site [ion binding]; other site 405531008913 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405531008914 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405531008915 DXD motif; other site 405531008916 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 405531008917 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 405531008918 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531008919 Protein of unknown function (DUF3963); Region: DUF3963; pfam13124 405531008920 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405531008921 HTH domain; Region: HTH_11; pfam08279 405531008922 WYL domain; Region: WYL; pfam13280 405531008923 ABC-2 type transporter; Region: ABC2_membrane; cl17235 405531008924 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405531008925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531008926 Walker A/P-loop; other site 405531008927 ATP binding site [chemical binding]; other site 405531008928 Q-loop/lid; other site 405531008929 ABC transporter signature motif; other site 405531008930 Walker B; other site 405531008931 D-loop; other site 405531008932 H-loop/switch region; other site 405531008933 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 405531008934 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531008935 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531008936 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 405531008937 hydroxylamine reductase; Provisional; Region: PRK12310 405531008938 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405531008939 ACS interaction site; other site 405531008940 CODH interaction site; other site 405531008941 metal cluster binding site [ion binding]; other site 405531008942 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531008943 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 405531008944 hypothetical protein; Provisional; Region: PRK06771 405531008945 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531008946 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531008947 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 405531008948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 405531008949 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 405531008950 dimer interface [polypeptide binding]; other site 405531008951 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531008952 ligand binding site [chemical binding]; other site 405531008953 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405531008954 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405531008955 ligand binding site [chemical binding]; other site 405531008956 flexible hinge region; other site 405531008957 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 405531008958 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405531008959 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405531008960 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531008961 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 405531008962 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 405531008963 putative NAD(P) binding site [chemical binding]; other site 405531008964 dimer interface [polypeptide binding]; other site 405531008965 putative transport protein YifK; Provisional; Region: PRK10746 405531008966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531008967 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405531008968 putative substrate translocation pore; other site 405531008969 Haemolysin XhlA; Region: XhlA; pfam10779 405531008970 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405531008971 classical (c) SDRs; Region: SDR_c; cd05233 405531008972 NAD(P) binding site [chemical binding]; other site 405531008973 active site 405531008974 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 405531008975 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 405531008976 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405531008977 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405531008978 transmembrane helices; other site 405531008979 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531008980 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531008981 Coenzyme A binding pocket [chemical binding]; other site 405531008982 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531008983 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405531008984 putative ligand binding residues [chemical binding]; other site 405531008985 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405531008986 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531008987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531008988 ABC-ATPase subunit interface; other site 405531008989 dimer interface [polypeptide binding]; other site 405531008990 putative PBP binding regions; other site 405531008991 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531008992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531008993 ABC-ATPase subunit interface; other site 405531008994 dimer interface [polypeptide binding]; other site 405531008995 putative PBP binding regions; other site 405531008996 Protein of unknown function (DUF817); Region: DUF817; pfam05675 405531008997 Protein of unknown function (DUF4003); Region: DUF4003; pfam13170 405531008998 DinB superfamily; Region: DinB_2; pfam12867 405531008999 DinB family; Region: DinB; cl17821 405531009000 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405531009001 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 405531009002 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531009003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531009004 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531009005 dimerization interface [polypeptide binding]; other site 405531009006 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405531009007 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405531009008 NADP binding site [chemical binding]; other site 405531009009 dimer interface [polypeptide binding]; other site 405531009010 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531009011 catalytic core [active] 405531009012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531009013 Coenzyme A binding pocket [chemical binding]; other site 405531009014 Group II catalytic intron 405531009015 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 405531009016 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405531009017 putative active site [active] 405531009018 putative NTP binding site [chemical binding]; other site 405531009019 putative nucleic acid binding site [nucleotide binding]; other site 405531009020 Type II intron maturase; Region: Intron_maturas2; pfam01348 405531009021 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 405531009022 MutS domain III; Region: MutS_III; pfam05192 405531009023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531009024 Walker A/P-loop; other site 405531009025 ATP binding site [chemical binding]; other site 405531009026 Q-loop/lid; other site 405531009027 ABC transporter signature motif; other site 405531009028 Walker B; other site 405531009029 D-loop; other site 405531009030 H-loop/switch region; other site 405531009031 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 405531009032 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 405531009033 active site 405531009034 Na/Ca binding site [ion binding]; other site 405531009035 catalytic site [active] 405531009036 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 405531009037 N-acetyltransferase; Region: Acetyltransf_2; cl00949 405531009038 oligoendopeptidase F; Region: pepF; TIGR00181 405531009039 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 405531009040 active site 405531009041 Zn binding site [ion binding]; other site 405531009042 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405531009043 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 405531009044 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405531009045 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531009046 DNA binding residues [nucleotide binding] 405531009047 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405531009048 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405531009049 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405531009050 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 405531009051 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 405531009052 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531009053 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531009054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531009055 putative substrate translocation pore; other site 405531009056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531009057 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531009058 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531009059 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405531009060 putative dimerization interface [polypeptide binding]; other site 405531009061 Protein of unknown function (DUF3916); Region: DUF3916; pfam13079 405531009062 Glycerophosphodiester phosphodiesterase domain of Staphylococcus aureus and similar proteins; Region: GDPD_SaGlpQ_like; cd08601 405531009063 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405531009064 active site 405531009065 catalytic site [active] 405531009066 metal binding site [ion binding]; metal-binding site 405531009067 FAD binding domain; Region: FAD_binding_3; pfam01494 405531009068 hypothetical protein; Provisional; Region: PRK07236 405531009069 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405531009070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531009071 dimerization interface [polypeptide binding]; other site 405531009072 putative DNA binding site [nucleotide binding]; other site 405531009073 putative Zn2+ binding site [ion binding]; other site 405531009074 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 405531009075 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 405531009076 putative NAD(P) binding site [chemical binding]; other site 405531009077 Uncharacterized conserved protein [Function unknown]; Region: COG0397 405531009078 hypothetical protein; Validated; Region: PRK00029 405531009079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531009080 TPR motif; other site 405531009081 binding surface 405531009082 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 405531009083 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 405531009084 Sodium Bile acid symporter family; Region: SBF; pfam01758 405531009085 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405531009086 FAD binding domain; Region: FAD_binding_4; pfam01565 405531009087 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 405531009088 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531009089 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531009090 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405531009091 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531009092 active site residue [active] 405531009093 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531009094 active site residue [active] 405531009095 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 405531009096 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531009097 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 405531009098 phosphate binding motif [ion binding]; other site 405531009099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 405531009100 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 405531009101 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 405531009102 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405531009103 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405531009104 pseudaminic acid synthase; Region: PseI; TIGR03586 405531009105 NeuB family; Region: NeuB; pfam03102 405531009106 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 405531009107 NeuB binding interface [polypeptide binding]; other site 405531009108 putative substrate binding site [chemical binding]; other site 405531009109 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 405531009110 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531009111 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 405531009112 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 405531009113 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 405531009114 ligand binding site; other site 405531009115 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405531009116 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405531009117 inhibitor-cofactor binding pocket; inhibition site 405531009118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531009119 catalytic residue [active] 405531009120 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531009121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531009122 NAD(P) binding site [chemical binding]; other site 405531009123 active site 405531009124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531009125 NAD(P) binding site [chemical binding]; other site 405531009126 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 405531009127 active site 405531009128 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 405531009129 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531009130 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405531009131 active site 405531009132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405531009133 active site 405531009134 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 405531009135 active site 405531009136 catalytic site [active] 405531009137 putative metal binding site [ion binding]; other site 405531009138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 405531009139 Chitin binding domain; Region: Chitin_bind_3; pfam03067 405531009140 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531009141 Interdomain contacts; other site 405531009142 Cytokine receptor motif; other site 405531009143 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531009144 Interdomain contacts; other site 405531009145 Cytokine receptor motif; other site 405531009146 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 405531009147 Fic/DOC family; Region: Fic; pfam02661 405531009148 Fic family protein [Function unknown]; Region: COG3177 405531009149 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531009150 Spore germination protein; Region: Spore_permease; cl17796 405531009151 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531009152 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531009153 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405531009154 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405531009155 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405531009156 active site 405531009157 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531009158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531009159 NAD(P) binding site [chemical binding]; other site 405531009160 active site 405531009161 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 405531009162 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 405531009163 NAD binding site [chemical binding]; other site 405531009164 homotetramer interface [polypeptide binding]; other site 405531009165 homodimer interface [polypeptide binding]; other site 405531009166 substrate binding site [chemical binding]; other site 405531009167 active site 405531009168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531009169 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531009170 TPR motif; other site 405531009171 binding surface 405531009172 Tar ligand binding domain homologue; Region: TarH; pfam02203 405531009173 Cache domain; Region: Cache_1; pfam02743 405531009174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531009175 dimerization interface [polypeptide binding]; other site 405531009176 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531009177 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531009178 dimer interface [polypeptide binding]; other site 405531009179 putative CheW interface [polypeptide binding]; other site 405531009180 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cd00257 405531009181 PKC phosphorylation site [posttranslational modification]; other site 405531009182 Peptidase M60-like family; Region: M60-like; pfam13402 405531009183 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 405531009184 PAS domain S-box; Region: sensory_box; TIGR00229 405531009185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531009186 putative active site [active] 405531009187 heme pocket [chemical binding]; other site 405531009188 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531009189 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531009190 metal binding site [ion binding]; metal-binding site 405531009191 active site 405531009192 I-site; other site 405531009193 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531009194 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531009195 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531009196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531009197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531009198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531009199 beta-channel forming cytolysin; Region: hlyII; TIGR01002 405531009200 S-layer homology domain; Region: SLH; pfam00395 405531009201 S-layer homology domain; Region: SLH; pfam00395 405531009202 S-layer homology domain; Region: SLH; pfam00395 405531009203 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405531009204 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405531009205 active site 405531009206 metal binding site [ion binding]; metal-binding site 405531009207 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405531009208 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405531009209 TQXA domain; Region: TQXA_dom; TIGR03934 405531009210 Cna protein B-type domain; Region: Cna_B; pfam05738 405531009211 Cna protein B-type domain; Region: Cna_B; pfam05738 405531009212 Cna protein B-type domain; Region: Cna_B; pfam05738 405531009213 Cna protein B-type domain; Region: Cna_B; pfam05738 405531009214 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 405531009215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531009216 dimer interface [polypeptide binding]; other site 405531009217 phosphorylation site [posttranslational modification] 405531009218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531009219 ATP binding site [chemical binding]; other site 405531009220 Mg2+ binding site [ion binding]; other site 405531009221 G-X-G motif; other site 405531009222 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 405531009223 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 405531009224 FOG: PKD repeat [General function prediction only]; Region: COG3291 405531009225 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 405531009226 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405531009227 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 405531009228 MgtC family; Region: MgtC; pfam02308 405531009229 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531009230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531009231 Coenzyme A binding pocket [chemical binding]; other site 405531009232 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405531009233 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405531009234 putative metal binding site [ion binding]; other site 405531009235 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 405531009236 active site 405531009237 VanW like protein; Region: VanW; pfam04294 405531009238 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 405531009239 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 405531009240 exonuclease; Provisional; Region: PRK06722 405531009241 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405531009242 active site 405531009243 catalytic site [active] 405531009244 substrate binding site [chemical binding]; other site 405531009245 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531009246 DNA-binding site [nucleotide binding]; DNA binding site 405531009247 RNA-binding motif; other site 405531009248 flavodoxin; Provisional; Region: PRK06703 405531009249 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 405531009250 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 405531009251 nudix motif; other site 405531009252 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 405531009253 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 405531009254 trimer interface [polypeptide binding]; other site 405531009255 active site 405531009256 substrate binding site [chemical binding]; other site 405531009257 CoA binding site [chemical binding]; other site 405531009258 Domain of unknown function DUF11; Region: DUF11; cl17728 405531009259 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009260 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009261 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009262 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009263 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009264 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009265 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009266 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009267 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009268 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009269 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009270 conserved repeat domain; Region: B_ant_repeat; TIGR01451 405531009271 short chain dehydrogenase; Provisional; Region: PRK06924 405531009272 sepiapterin reductase (SPR)-like, classical (c) SDRs; Region: SPR-like_SDR_c; cd05367 405531009273 NADP binding site [chemical binding]; other site 405531009274 homodimer interface [polypeptide binding]; other site 405531009275 active site 405531009276 Predicted acetyltransferase [General function prediction only]; Region: COG3393 405531009277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531009278 argininosuccinate lyase; Provisional; Region: PRK06705 405531009279 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405531009280 active sites [active] 405531009281 tetramer interface [polypeptide binding]; other site 405531009282 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531009283 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531009284 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405531009285 active site 405531009286 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405531009287 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 405531009288 Na binding site [ion binding]; other site 405531009289 Protein of unknown function (DUF997); Region: DUF997; pfam06196 405531009290 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 405531009291 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405531009292 NAD(P) binding site [chemical binding]; other site 405531009293 catalytic residues [active] 405531009294 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 405531009295 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405531009296 NAD(P) binding site [chemical binding]; other site 405531009297 homotetramer interface [polypeptide binding]; other site 405531009298 homodimer interface [polypeptide binding]; other site 405531009299 active site 405531009300 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 405531009301 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 405531009302 Divergent PAP2 family; Region: DUF212; pfam02681 405531009303 Predicted permeases [General function prediction only]; Region: RarD; COG2962 405531009304 EamA-like transporter family; Region: EamA; pfam00892 405531009305 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 405531009306 Domain of unknown function DUF59; Region: DUF59; pfam01883 405531009307 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 405531009308 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405531009309 Walker A motif; other site 405531009310 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405531009311 MoaE interaction surface [polypeptide binding]; other site 405531009312 MoeB interaction surface [polypeptide binding]; other site 405531009313 thiocarboxylated glycine; other site 405531009314 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405531009315 MoaE homodimer interface [polypeptide binding]; other site 405531009316 MoaD interaction [polypeptide binding]; other site 405531009317 active site residues [active] 405531009318 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405531009319 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405531009320 dimer interface [polypeptide binding]; other site 405531009321 putative functional site; other site 405531009322 putative MPT binding site; other site 405531009323 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405531009324 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405531009325 ATP binding site [chemical binding]; other site 405531009326 substrate interface [chemical binding]; other site 405531009327 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405531009328 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 405531009329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531009330 FeS/SAM binding site; other site 405531009331 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405531009332 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405531009333 Uncharacterized conserved protein [Function unknown]; Region: COG5609 405531009334 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405531009335 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 405531009336 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405531009337 catalytic loop [active] 405531009338 iron binding site [ion binding]; other site 405531009339 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405531009340 4Fe-4S binding domain; Region: Fer4; pfam00037 405531009341 4Fe-4S binding domain; Region: Fer4; pfam00037 405531009342 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 405531009343 [4Fe-4S] binding site [ion binding]; other site 405531009344 molybdopterin cofactor binding site; other site 405531009345 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405531009346 molybdopterin cofactor binding site; other site 405531009347 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531009348 spore germination protein (amino acid permease); Region: 2A0309; TIGR00912 405531009349 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531009350 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531009351 Tubulin like; Region: Tubulin_2; pfam13809 405531009352 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 405531009353 metal ion-dependent adhesion site (MIDAS); other site 405531009354 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531009355 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531009356 active site 405531009357 metal binding site [ion binding]; metal-binding site 405531009358 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405531009359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531009360 S-adenosylmethionine binding site [chemical binding]; other site 405531009361 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531009362 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531009363 peptide binding site [polypeptide binding]; other site 405531009364 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531009365 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531009366 peptide binding site [polypeptide binding]; other site 405531009367 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405531009368 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405531009369 peptide binding site [polypeptide binding]; other site 405531009370 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 405531009371 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405531009372 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405531009373 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 405531009374 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531009375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531009376 DNA binding residues [nucleotide binding] 405531009377 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405531009378 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531009379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531009380 Walker A/P-loop; other site 405531009381 ATP binding site [chemical binding]; other site 405531009382 Q-loop/lid; other site 405531009383 ABC transporter signature motif; other site 405531009384 Walker B; other site 405531009385 D-loop; other site 405531009386 H-loop/switch region; other site 405531009387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531009388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531009389 Predicted transcriptional regulator [Transcription]; Region: COG2378 405531009390 HTH domain; Region: HTH_11; pfam08279 405531009391 WYL domain; Region: WYL; pfam13280 405531009392 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405531009393 dimer interface [polypeptide binding]; other site 405531009394 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531009395 putative oxidoreductase; Provisional; Region: PRK11579 405531009396 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405531009397 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405531009398 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 405531009399 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405531009400 CAP-like domain; other site 405531009401 active site 405531009402 primary dimer interface [polypeptide binding]; other site 405531009403 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531009404 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531009405 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405531009406 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 405531009407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531009408 ATP binding site [chemical binding]; other site 405531009409 Mg2+ binding site [ion binding]; other site 405531009410 G-X-G motif; other site 405531009411 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405531009412 anchoring element; other site 405531009413 dimer interface [polypeptide binding]; other site 405531009414 ATP binding site [chemical binding]; other site 405531009415 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405531009416 active site 405531009417 putative metal-binding site [ion binding]; other site 405531009418 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405531009419 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 405531009420 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405531009421 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405531009422 protein binding site [polypeptide binding]; other site 405531009423 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531009424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531009425 active site 405531009426 phosphorylation site [posttranslational modification] 405531009427 intermolecular recognition site; other site 405531009428 dimerization interface [polypeptide binding]; other site 405531009429 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531009430 DNA binding site [nucleotide binding] 405531009431 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 405531009432 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531009433 FeS/SAM binding site; other site 405531009434 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 405531009435 Class III ribonucleotide reductase; Region: RNR_III; cd01675 405531009436 effector binding site; other site 405531009437 active site 405531009438 Zn binding site [ion binding]; other site 405531009439 glycine loop; other site 405531009440 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405531009441 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 405531009442 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405531009443 active site 405531009444 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 405531009445 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531009446 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531009447 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 405531009448 active site 405531009449 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 405531009450 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 405531009451 DNA polymerase III subunit epsilon; Validated; Region: PRK06807 405531009452 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405531009453 active site 405531009454 catalytic site [active] 405531009455 substrate binding site [chemical binding]; other site 405531009456 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 405531009457 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405531009458 catalytic residues [active] 405531009459 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531009460 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531009461 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531009462 Walker A/P-loop; other site 405531009463 ATP binding site [chemical binding]; other site 405531009464 Q-loop/lid; other site 405531009465 ABC transporter signature motif; other site 405531009466 Walker B; other site 405531009467 D-loop; other site 405531009468 H-loop/switch region; other site 405531009469 aconitate hydratase; Validated; Region: PRK09277 405531009470 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 405531009471 substrate binding site [chemical binding]; other site 405531009472 ligand binding site [chemical binding]; other site 405531009473 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 405531009474 substrate binding site [chemical binding]; other site 405531009475 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 405531009476 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531009477 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 405531009478 NodB motif; other site 405531009479 active site 405531009480 catalytic site [active] 405531009481 metal binding site [ion binding]; metal-binding site 405531009482 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405531009483 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 405531009484 putative dimer interface [polypeptide binding]; other site 405531009485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531009486 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531009487 putative substrate translocation pore; other site 405531009488 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 405531009489 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405531009490 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405531009491 nudix motif; other site 405531009492 SAP domain; Region: SAP; cl02640 405531009493 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 405531009494 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405531009495 dimer interface [polypeptide binding]; other site 405531009496 active site 405531009497 acyl-CoA synthetase; Validated; Region: PRK07638 405531009498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405531009499 acyl-activating enzyme (AAE) consensus motif; other site 405531009500 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405531009501 acyl-activating enzyme (AAE) consensus motif; other site 405531009502 AMP binding site [chemical binding]; other site 405531009503 active site 405531009504 CoA binding site [chemical binding]; other site 405531009505 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 405531009506 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 405531009507 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 405531009508 dimer interface [polypeptide binding]; other site 405531009509 acyl-activating enzyme (AAE) consensus motif; other site 405531009510 putative active site [active] 405531009511 AMP binding site [chemical binding]; other site 405531009512 putative CoA binding site [chemical binding]; other site 405531009513 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531009514 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531009515 non-specific DNA binding site [nucleotide binding]; other site 405531009516 salt bridge; other site 405531009517 sequence-specific DNA binding site [nucleotide binding]; other site 405531009518 potential frameshift: common BLAST hit: gi|118478870|ref|YP_896021.1| acetyltransferase 405531009519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531009520 Coenzyme A binding pocket [chemical binding]; other site 405531009521 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 405531009522 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531009523 amidase catalytic site [active] 405531009524 Zn binding residues [ion binding]; other site 405531009525 substrate binding site [chemical binding]; other site 405531009526 active site 405531009527 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405531009528 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531009529 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531009530 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531009531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531009532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 405531009533 dimer interface [polypeptide binding]; other site 405531009534 putative metal binding site [ion binding]; other site 405531009535 PAS domain S-box; Region: sensory_box; TIGR00229 405531009536 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531009537 putative active site [active] 405531009538 heme pocket [chemical binding]; other site 405531009539 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405531009540 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531009541 putative active site [active] 405531009542 heme pocket [chemical binding]; other site 405531009543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531009544 dimer interface [polypeptide binding]; other site 405531009545 phosphorylation site [posttranslational modification] 405531009546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531009547 ATP binding site [chemical binding]; other site 405531009548 Mg2+ binding site [ion binding]; other site 405531009549 G-X-G motif; other site 405531009550 Predicted esterase [General function prediction only]; Region: COG0400 405531009551 putative hydrolase; Provisional; Region: PRK11460 405531009552 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 405531009553 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531009554 Zn binding site [ion binding]; other site 405531009555 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 405531009556 Zn binding site [ion binding]; other site 405531009557 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405531009558 Na binding site [ion binding]; other site 405531009559 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405531009560 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 405531009561 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405531009562 active site 405531009563 FMN binding site [chemical binding]; other site 405531009564 substrate binding site [chemical binding]; other site 405531009565 3Fe-4S cluster binding site [ion binding]; other site 405531009566 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405531009567 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 405531009568 FMN binding site [chemical binding]; other site 405531009569 active site 405531009570 substrate binding site [chemical binding]; other site 405531009571 catalytic residue [active] 405531009572 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 405531009573 agmatinase; Region: agmatinase; TIGR01230 405531009574 Agmatinase-like family; Region: Agmatinase-like; cd09990 405531009575 active site 405531009576 oligomer interface [polypeptide binding]; other site 405531009577 Mn binding site [ion binding]; other site 405531009578 imidazolonepropionase; Validated; Region: PRK09356 405531009579 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 405531009580 active site 405531009581 urocanate hydratase; Provisional; Region: PRK05414 405531009582 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 405531009583 active sites [active] 405531009584 tetramer interface [polypeptide binding]; other site 405531009585 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 405531009586 hexamer interface [polypeptide binding]; other site 405531009587 RNA binding site [nucleotide binding]; other site 405531009588 Histidine-zinc binding site [chemical binding]; other site 405531009589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531009590 S-adenosylmethionine binding site [chemical binding]; other site 405531009591 DJ-1 family protein; Region: not_thiJ; TIGR01383 405531009592 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 405531009593 conserved cys residue [active] 405531009594 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405531009595 AAA domain; Region: AAA_28; pfam13521 405531009596 active site 405531009597 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 405531009598 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 405531009599 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 405531009600 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 405531009601 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405531009602 EamA-like transporter family; Region: EamA; pfam00892 405531009603 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 405531009604 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405531009605 metal binding site [ion binding]; metal-binding site 405531009606 dimer interface [polypeptide binding]; other site 405531009607 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 405531009608 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405531009609 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531009610 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531009611 Walker A/P-loop; other site 405531009612 ATP binding site [chemical binding]; other site 405531009613 Q-loop/lid; other site 405531009614 ABC transporter signature motif; other site 405531009615 Walker B; other site 405531009616 D-loop; other site 405531009617 H-loop/switch region; other site 405531009618 Probable transposase; Region: OrfB_IS605; pfam01385 405531009619 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531009620 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405531009621 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 405531009622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531009623 The C-terminal substrate binding domain of LysR-type trnascriptional regulator AlsR, which regulates acetoin formation under stationary phase growth conditions; contains the type 2 periplasmic binding fold; Region: PBP2_AlsR; cd08452 405531009624 putative dimerization interface [polypeptide binding]; other site 405531009625 putative substrate binding pocket [chemical binding]; other site 405531009626 holin-like protein; Validated; Region: PRK01658 405531009627 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405531009628 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405531009629 nudix motif; other site 405531009630 Domain of unknown function (DUF3903); Region: DUF3903; pfam13043 405531009631 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 405531009632 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 405531009633 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405531009634 active site 405531009635 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531009636 Bacterial SH3 domain; Region: SH3_3; cl17532 405531009637 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531009638 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531009639 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405531009640 Walker A/P-loop; other site 405531009641 ATP binding site [chemical binding]; other site 405531009642 Q-loop/lid; other site 405531009643 ABC transporter signature motif; other site 405531009644 Walker B; other site 405531009645 D-loop; other site 405531009646 H-loop/switch region; other site 405531009647 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531009648 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405531009649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531009650 Walker A/P-loop; other site 405531009651 ATP binding site [chemical binding]; other site 405531009652 Q-loop/lid; other site 405531009653 ABC transporter signature motif; other site 405531009654 Walker B; other site 405531009655 D-loop; other site 405531009656 H-loop/switch region; other site 405531009657 hypothetical protein; Provisional; Region: PRK01844 405531009658 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 405531009659 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 405531009660 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405531009661 TPP-binding site [chemical binding]; other site 405531009662 dimer interface [polypeptide binding]; other site 405531009663 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405531009664 PYR/PP interface [polypeptide binding]; other site 405531009665 dimer interface [polypeptide binding]; other site 405531009666 TPP binding site [chemical binding]; other site 405531009667 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405531009668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531009669 dimer interface [polypeptide binding]; other site 405531009670 conserved gate region; other site 405531009671 ABC-ATPase subunit interface; other site 405531009672 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 405531009673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531009674 dimer interface [polypeptide binding]; other site 405531009675 conserved gate region; other site 405531009676 ABC-ATPase subunit interface; other site 405531009677 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 405531009678 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 405531009679 Walker A/P-loop; other site 405531009680 ATP binding site [chemical binding]; other site 405531009681 Q-loop/lid; other site 405531009682 ABC transporter signature motif; other site 405531009683 Walker B; other site 405531009684 D-loop; other site 405531009685 H-loop/switch region; other site 405531009686 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 405531009687 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531009688 membrane-bound complex binding site; other site 405531009689 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405531009690 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405531009691 active site 405531009692 metal binding site [ion binding]; metal-binding site 405531009693 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405531009694 hypothetical protein; Provisional; Region: PRK01546 405531009695 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405531009696 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405531009697 catalytic residues [active] 405531009698 catalytic nucleophile [active] 405531009699 LexA repressor; Validated; Region: PRK00215 405531009700 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531009701 putative DNA binding site [nucleotide binding]; other site 405531009702 putative Zn2+ binding site [ion binding]; other site 405531009703 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405531009704 Catalytic site [active] 405531009705 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 405531009706 Uncharacterized conserved protein [Function unknown]; Region: COG3595 405531009707 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 405531009708 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 405531009709 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531009710 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531009711 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 405531009712 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531009713 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531009714 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405531009715 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405531009716 catalytic residue [active] 405531009717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 405531009718 DNA binding residues [nucleotide binding] 405531009719 Helix-turn-helix domain; Region: HTH_36; pfam13730 405531009720 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 405531009721 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713 405531009722 ORF6C domain; Region: ORF6C; pfam10552 405531009723 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 405531009724 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531009725 salt bridge; other site 405531009726 non-specific DNA binding site [nucleotide binding]; other site 405531009727 sequence-specific DNA binding site [nucleotide binding]; other site 405531009728 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405531009729 Catalytic site [active] 405531009730 glutamine synthetase, type I; Region: GlnA; TIGR00653 405531009731 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 405531009732 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 405531009733 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 405531009734 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531009735 DNA binding residues [nucleotide binding] 405531009736 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 405531009737 Aluminium resistance protein; Region: Alum_res; pfam06838 405531009738 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 405531009739 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405531009740 HflX GTPase family; Region: HflX; cd01878 405531009741 G1 box; other site 405531009742 GTP/Mg2+ binding site [chemical binding]; other site 405531009743 Switch I region; other site 405531009744 G2 box; other site 405531009745 G3 box; other site 405531009746 Switch II region; other site 405531009747 G4 box; other site 405531009748 G5 box; other site 405531009749 Predicted membrane protein [Function unknown]; Region: COG2860 405531009750 UPF0126 domain; Region: UPF0126; pfam03458 405531009751 UPF0126 domain; Region: UPF0126; pfam03458 405531009752 stage V sporulation protein K; Region: spore_V_K; TIGR02881 405531009753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531009754 Walker A motif; other site 405531009755 ATP binding site [chemical binding]; other site 405531009756 Walker B motif; other site 405531009757 arginine finger; other site 405531009758 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 405531009759 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405531009760 active site 405531009761 catalytic residues [active] 405531009762 DNA binding site [nucleotide binding] 405531009763 Int/Topo IB signature motif; other site 405531009764 Protein of unknown function (DUF3982); Region: DUF3982; pfam13138 405531009765 bacterial Hfq-like; Region: Hfq; cd01716 405531009766 hexamer interface [polypeptide binding]; other site 405531009767 Sm1 motif; other site 405531009768 RNA binding site [nucleotide binding]; other site 405531009769 Sm2 motif; other site 405531009770 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 405531009771 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 405531009772 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531009773 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531009774 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405531009775 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 405531009776 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405531009777 active site 405531009778 phosphorylation site [posttranslational modification] 405531009779 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405531009780 active site 405531009781 P-loop; other site 405531009782 phosphorylation site [posttranslational modification] 405531009783 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 405531009784 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 405531009785 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405531009786 putative substrate binding site [chemical binding]; other site 405531009787 putative ATP binding site [chemical binding]; other site 405531009788 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405531009789 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405531009790 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405531009791 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 405531009792 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 405531009793 dimer interface [polypeptide binding]; other site 405531009794 active site 405531009795 metal binding site [ion binding]; metal-binding site 405531009796 Predicted membrane protein [Function unknown]; Region: COG2322 405531009797 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 405531009798 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 405531009799 Glyco_18 domain; Region: Glyco_18; smart00636 405531009800 putative active site [active] 405531009801 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405531009802 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405531009803 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531009804 putative active site [active] 405531009805 putative metal binding site [ion binding]; other site 405531009806 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 405531009807 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405531009808 IHF dimer interface [polypeptide binding]; other site 405531009809 IHF - DNA interface [nucleotide binding]; other site 405531009810 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531009811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531009812 Coenzyme A binding pocket [chemical binding]; other site 405531009813 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405531009814 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405531009815 metal-binding site [ion binding] 405531009816 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405531009817 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405531009818 metal-binding site [ion binding] 405531009819 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531009820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531009821 motif II; other site 405531009822 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 405531009823 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405531009824 metal-binding site [ion binding] 405531009825 Bacillus subtilis copper-sensitive operon repressor (BsCsoR), and related domains; this family was previously known as part of DUF156; Region: BsCsoR-like_DUF156; cd10157 405531009826 putative homodimer interface [polypeptide binding]; other site 405531009827 putative homotetramer interface [polypeptide binding]; other site 405531009828 allosteric switch controlling residues; other site 405531009829 putative metal binding site [ion binding]; other site 405531009830 putative homodimer-homodimer interface [polypeptide binding]; other site 405531009831 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531009832 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531009833 DNA binding residues [nucleotide binding] 405531009834 dimerization interface [polypeptide binding]; other site 405531009835 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531009836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531009837 S-adenosylmethionine binding site [chemical binding]; other site 405531009838 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405531009839 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405531009840 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405531009841 Walker A/P-loop; other site 405531009842 ATP binding site [chemical binding]; other site 405531009843 Q-loop/lid; other site 405531009844 ABC transporter signature motif; other site 405531009845 Walker B; other site 405531009846 D-loop; other site 405531009847 H-loop/switch region; other site 405531009848 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531009849 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531009850 ABC-ATPase subunit interface; other site 405531009851 dimer interface [polypeptide binding]; other site 405531009852 putative PBP binding regions; other site 405531009853 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531009854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531009855 ABC-ATPase subunit interface; other site 405531009856 dimer interface [polypeptide binding]; other site 405531009857 putative PBP binding regions; other site 405531009858 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405531009859 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405531009860 putative ligand binding residues [chemical binding]; other site 405531009861 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 405531009862 active site 405531009863 putative catalytic site [active] 405531009864 DNA binding site [nucleotide binding] 405531009865 putative phosphate binding site [ion binding]; other site 405531009866 metal binding site A [ion binding]; metal-binding site 405531009867 AP binding site [nucleotide binding]; other site 405531009868 metal binding site B [ion binding]; metal-binding site 405531009869 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 405531009870 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405531009871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531009872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531009873 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405531009874 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405531009875 DNA binding site [nucleotide binding] 405531009876 active site 405531009877 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 405531009878 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405531009879 endonuclease III; Region: ENDO3c; smart00478 405531009880 minor groove reading motif; other site 405531009881 helix-hairpin-helix signature motif; other site 405531009882 substrate binding pocket [chemical binding]; other site 405531009883 active site 405531009884 peptidase T; Region: peptidase-T; TIGR01882 405531009885 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405531009886 metal binding site [ion binding]; metal-binding site 405531009887 dimer interface [polypeptide binding]; other site 405531009888 Predicted membrane protein [Function unknown]; Region: COG2364 405531009889 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531009890 hypothetical protein; Provisional; Region: PRK06764 405531009891 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531009892 catalytic core [active] 405531009893 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531009894 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 405531009895 PAS domain S-box; Region: sensory_box; TIGR00229 405531009896 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531009897 putative active site [active] 405531009898 heme pocket [chemical binding]; other site 405531009899 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531009900 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531009901 metal binding site [ion binding]; metal-binding site 405531009902 active site 405531009903 I-site; other site 405531009904 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531009905 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 405531009906 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405531009907 active site 405531009908 homodimer interface [polypeptide binding]; other site 405531009909 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531009910 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 405531009911 NAD(P) binding site [chemical binding]; other site 405531009912 active site 405531009913 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 405531009914 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 405531009915 NAD(P) binding site [chemical binding]; other site 405531009916 homodimer interface [polypeptide binding]; other site 405531009917 substrate binding site [chemical binding]; other site 405531009918 active site 405531009919 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 405531009920 Uncharacterized protein from bacillus cereus group; Region: YfmQ; pfam10787 405531009921 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405531009922 holin-like protein; Validated; Region: PRK01658 405531009923 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405531009924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531009925 DNA-binding site [nucleotide binding]; DNA binding site 405531009926 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531009927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531009928 homodimer interface [polypeptide binding]; other site 405531009929 catalytic residue [active] 405531009930 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 405531009931 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531009932 dimerization interface [polypeptide binding]; other site 405531009933 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531009934 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531009935 dimer interface [polypeptide binding]; other site 405531009936 putative CheW interface [polypeptide binding]; other site 405531009937 Catalytic domain of prokaryotic and eukaryotic phosphoinositide-specific phospholipase C; Region: PI-PLCc; cd00137 405531009938 active site 405531009939 catalytic site [active] 405531009940 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 405531009941 putative active site [active] 405531009942 putative catalytic triad [active] 405531009943 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405531009944 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531009945 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 405531009946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531009947 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405531009948 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 405531009949 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405531009950 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405531009951 Sulfatase; Region: Sulfatase; pfam00884 405531009952 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531009953 binding surface 405531009954 TPR motif; other site 405531009955 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 405531009956 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 405531009957 GTP/Mg2+ binding site [chemical binding]; other site 405531009958 G4 box; other site 405531009959 G5 box; other site 405531009960 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405531009961 G1 box; other site 405531009962 G1 box; other site 405531009963 GTP/Mg2+ binding site [chemical binding]; other site 405531009964 Switch I region; other site 405531009965 G3 box; other site 405531009966 Switch II region; other site 405531009967 G4 box; other site 405531009968 G5 box; other site 405531009969 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 405531009970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531009971 ATP binding site [chemical binding]; other site 405531009972 Mg2+ binding site [ion binding]; other site 405531009973 G-X-G motif; other site 405531009974 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 405531009975 ATP binding site [chemical binding]; other site 405531009976 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 405531009977 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 405531009978 MutS domain I; Region: MutS_I; pfam01624 405531009979 MutS domain II; Region: MutS_II; pfam05188 405531009980 MutS domain III; Region: MutS_III; pfam05192 405531009981 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 405531009982 Walker A/P-loop; other site 405531009983 ATP binding site [chemical binding]; other site 405531009984 Q-loop/lid; other site 405531009985 ABC transporter signature motif; other site 405531009986 Walker B; other site 405531009987 D-loop; other site 405531009988 H-loop/switch region; other site 405531009989 Outer spore coat protein E (CotE); Region: CotE; pfam10628 405531009990 Predicted membrane protein [Function unknown]; Region: COG4550 405531009991 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 405531009992 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405531009993 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531009994 FeS/SAM binding site; other site 405531009995 TRAM domain; Region: TRAM; pfam01938 405531009996 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 405531009997 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 405531009998 TPP-binding site [chemical binding]; other site 405531009999 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 405531010000 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 405531010001 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 405531010002 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 405531010003 dimer interface [polypeptide binding]; other site 405531010004 PYR/PP interface [polypeptide binding]; other site 405531010005 TPP binding site [chemical binding]; other site 405531010006 substrate binding site [chemical binding]; other site 405531010007 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405531010008 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 405531010009 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 405531010010 active site 405531010011 dimer interface [polypeptide binding]; other site 405531010012 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 405531010013 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 405531010014 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531010015 putative active site [active] 405531010016 metal binding site [ion binding]; metal-binding site 405531010017 homodimer binding site [polypeptide binding]; other site 405531010018 phosphodiesterase; Provisional; Region: PRK12704 405531010019 Uncharacterized conserved protein [Function unknown]; Region: COG3334 405531010020 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531010021 Zn2+ binding site [ion binding]; other site 405531010022 Mg2+ binding site [ion binding]; other site 405531010023 recombinase A; Provisional; Region: recA; PRK09354 405531010024 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 405531010025 hexamer interface [polypeptide binding]; other site 405531010026 Walker A motif; other site 405531010027 ATP binding site [chemical binding]; other site 405531010028 Walker B motif; other site 405531010029 competence damage-inducible protein A; Provisional; Region: PRK00549 405531010030 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 405531010031 putative MPT binding site; other site 405531010032 Competence-damaged protein; Region: CinA; pfam02464 405531010033 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 405531010034 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 405531010035 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531010036 non-specific DNA binding site [nucleotide binding]; other site 405531010037 salt bridge; other site 405531010038 sequence-specific DNA binding site [nucleotide binding]; other site 405531010039 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 405531010040 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405531010041 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 405531010042 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 405531010043 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 405531010044 classical (c) SDRs; Region: SDR_c; cd05233 405531010045 NAD(P) binding site [chemical binding]; other site 405531010046 active site 405531010047 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405531010048 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405531010049 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405531010050 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405531010051 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405531010052 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405531010053 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405531010054 TM-ABC transporter signature motif; other site 405531010055 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405531010056 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 405531010057 TM-ABC transporter signature motif; other site 405531010058 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 405531010059 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405531010060 Walker A/P-loop; other site 405531010061 ATP binding site [chemical binding]; other site 405531010062 Q-loop/lid; other site 405531010063 ABC transporter signature motif; other site 405531010064 Walker B; other site 405531010065 D-loop; other site 405531010066 H-loop/switch region; other site 405531010067 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405531010068 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 405531010069 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 405531010070 ligand binding site [chemical binding]; other site 405531010071 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405531010072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531010073 DNA-binding site [nucleotide binding]; DNA binding site 405531010074 UTRA domain; Region: UTRA; pfam07702 405531010075 Tetraspanin family; Region: Tetraspannin; pfam00335 405531010076 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405531010077 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405531010078 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405531010079 YlzJ-like protein; Region: YlzJ; pfam14035 405531010080 Clp protease; Region: CLP_protease; pfam00574 405531010081 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 405531010082 active site 405531010083 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405531010084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531010085 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405531010086 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 405531010087 dihydrodipicolinate synthase; Region: dapA; TIGR00674 405531010088 dimer interface [polypeptide binding]; other site 405531010089 active site 405531010090 catalytic residue [active] 405531010091 aspartate kinase I; Reviewed; Region: PRK08210 405531010092 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 405531010093 nucleotide binding site [chemical binding]; other site 405531010094 substrate binding site [chemical binding]; other site 405531010095 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 405531010096 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405531010097 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 405531010098 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405531010099 Flavoprotein; Region: Flavoprotein; cl08021 405531010100 Domain of unknown function (DUF3994); Region: DUF3994; pfam13159 405531010101 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 405531010102 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 405531010103 active site 405531010104 N-acetylmuramoyl-l-alanine amidase; Region: Amidase02_C; pfam12123 405531010105 Protein of unknown function (DUF2762); Region: DUF2762; pfam10960 405531010106 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 405531010107 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531010108 Phage tail protein; Region: Sipho_tail; pfam05709 405531010109 Phage tail protein; Region: Sipho_tail; cl17486 405531010110 Phage-related protein [Function unknown]; Region: COG5412 405531010111 Group I catalytic intron 405531010112 Phage-related minor tail protein [Function unknown]; Region: COG5280 405531010113 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 405531010114 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405531010115 Phage capsid family; Region: Phage_capsid; pfam05065 405531010116 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405531010117 oligomer interface [polypeptide binding]; other site 405531010118 active site residues [active] 405531010119 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 405531010120 Phage-related protein [Function unknown]; Region: COG4695; cl01923 405531010121 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405531010122 Phage terminase, small subunit; Region: Terminase_4; cl01525 405531010123 HNH endonuclease; Region: HNH; pfam01844 405531010124 active site 405531010125 TIR domain; Region: TIR_2; pfam13676 405531010126 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531010127 DNA-binding site [nucleotide binding]; DNA binding site 405531010128 RNA-binding motif; other site 405531010129 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405531010130 Int/Topo IB signature motif; other site 405531010131 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 405531010132 Protein of unknown function (DUF3954); Region: DUF3954; pfam13128 405531010133 replicative DNA helicase; Provisional; Region: PRK06749 405531010134 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405531010135 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405531010136 Walker A motif; other site 405531010137 ATP binding site [chemical binding]; other site 405531010138 Walker B motif; other site 405531010139 DNA binding loops [nucleotide binding] 405531010140 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405531010141 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531010142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531010143 non-specific DNA binding site [nucleotide binding]; other site 405531010144 salt bridge; other site 405531010145 sequence-specific DNA binding site [nucleotide binding]; other site 405531010146 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531010147 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531010148 non-specific DNA binding site [nucleotide binding]; other site 405531010149 salt bridge; other site 405531010150 sequence-specific DNA binding site [nucleotide binding]; other site 405531010151 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 405531010152 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405531010153 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405531010154 catalytic residues [active] 405531010155 catalytic nucleophile [active] 405531010156 Recombinase; Region: Recombinase; pfam07508 405531010157 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405531010158 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 405531010159 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 405531010160 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405531010161 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405531010162 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405531010163 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405531010164 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405531010165 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 405531010166 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 405531010167 NodB motif; other site 405531010168 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 405531010169 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 405531010170 RNase E interface [polypeptide binding]; other site 405531010171 trimer interface [polypeptide binding]; other site 405531010172 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 405531010173 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 405531010174 RNase E interface [polypeptide binding]; other site 405531010175 trimer interface [polypeptide binding]; other site 405531010176 active site 405531010177 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 405531010178 putative nucleic acid binding region [nucleotide binding]; other site 405531010179 G-X-X-G motif; other site 405531010180 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 405531010181 RNA binding site [nucleotide binding]; other site 405531010182 domain interface; other site 405531010183 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 405531010184 16S/18S rRNA binding site [nucleotide binding]; other site 405531010185 S13e-L30e interaction site [polypeptide binding]; other site 405531010186 25S rRNA binding site [nucleotide binding]; other site 405531010187 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 405531010188 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 405531010189 active site 405531010190 Riboflavin kinase; Region: Flavokinase; pfam01687 405531010191 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 405531010192 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 405531010193 RNA binding site [nucleotide binding]; other site 405531010194 active site 405531010195 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 405531010196 Protein of unknown function (DUF503); Region: DUF503; pfam04456 405531010197 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405531010198 translation initiation factor IF-2; Region: IF-2; TIGR00487 405531010199 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405531010200 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 405531010201 G1 box; other site 405531010202 putative GEF interaction site [polypeptide binding]; other site 405531010203 GTP/Mg2+ binding site [chemical binding]; other site 405531010204 Switch I region; other site 405531010205 G2 box; other site 405531010206 G3 box; other site 405531010207 Switch II region; other site 405531010208 G4 box; other site 405531010209 G5 box; other site 405531010210 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 405531010211 Translation-initiation factor 2; Region: IF-2; pfam11987 405531010212 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 405531010213 hypothetical protein; Provisional; Region: PRK07714 405531010214 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 405531010215 putative RNA binding cleft [nucleotide binding]; other site 405531010216 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 405531010217 NusA N-terminal domain; Region: NusA_N; pfam08529 405531010218 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 405531010219 RNA binding site [nucleotide binding]; other site 405531010220 homodimer interface [polypeptide binding]; other site 405531010221 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405531010222 G-X-X-G motif; other site 405531010223 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405531010224 G-X-X-G motif; other site 405531010225 ribosome maturation protein RimP; Reviewed; Region: PRK00092 405531010226 Sm and related proteins; Region: Sm_like; cl00259 405531010227 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 405531010228 putative oligomer interface [polypeptide binding]; other site 405531010229 putative RNA binding site [nucleotide binding]; other site 405531010230 DNA polymerase III PolC; Validated; Region: polC; PRK00448 405531010231 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 405531010232 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 405531010233 generic binding surface II; other site 405531010234 generic binding surface I; other site 405531010235 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405531010236 active site 405531010237 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405531010238 active site 405531010239 catalytic site [active] 405531010240 substrate binding site [chemical binding]; other site 405531010241 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 405531010242 prolyl-tRNA synthetase; Provisional; Region: PRK09194 405531010243 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 405531010244 dimer interface [polypeptide binding]; other site 405531010245 motif 1; other site 405531010246 active site 405531010247 motif 2; other site 405531010248 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 405531010249 putative deacylase active site [active] 405531010250 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405531010251 active site 405531010252 motif 3; other site 405531010253 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 405531010254 anticodon binding site; other site 405531010255 RIP metalloprotease RseP; Region: TIGR00054 405531010256 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405531010257 active site 405531010258 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405531010259 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405531010260 protein binding site [polypeptide binding]; other site 405531010261 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405531010262 putative substrate binding region [chemical binding]; other site 405531010263 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 405531010264 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405531010265 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405531010266 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405531010267 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 405531010268 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 405531010269 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 405531010270 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 405531010271 catalytic residue [active] 405531010272 putative FPP diphosphate binding site; other site 405531010273 putative FPP binding hydrophobic cleft; other site 405531010274 dimer interface [polypeptide binding]; other site 405531010275 putative IPP diphosphate binding site; other site 405531010276 ribosome recycling factor; Reviewed; Region: frr; PRK00083 405531010277 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 405531010278 hinge region; other site 405531010279 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405531010280 putative nucleotide binding site [chemical binding]; other site 405531010281 uridine monophosphate binding site [chemical binding]; other site 405531010282 homohexameric interface [polypeptide binding]; other site 405531010283 elongation factor Ts; Provisional; Region: tsf; PRK09377 405531010284 UBA/TS-N domain; Region: UBA; pfam00627 405531010285 Elongation factor TS; Region: EF_TS; pfam00889 405531010286 Elongation factor TS; Region: EF_TS; pfam00889 405531010287 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 405531010288 rRNA interaction site [nucleotide binding]; other site 405531010289 S8 interaction site; other site 405531010290 putative laminin-1 binding site; other site 405531010291 transcriptional repressor CodY; Validated; Region: PRK04158 405531010292 CodY GAF-like domain; Region: CodY; pfam06018 405531010293 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 405531010294 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 405531010295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531010296 Walker A motif; other site 405531010297 ATP binding site [chemical binding]; other site 405531010298 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 405531010299 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405531010300 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 405531010301 active site 405531010302 HslU subunit interaction site [polypeptide binding]; other site 405531010303 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 405531010304 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405531010305 active site 405531010306 Int/Topo IB signature motif; other site 405531010307 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 405531010308 Glucose inhibited division protein A; Region: GIDA; pfam01134 405531010309 DNA topoisomerase I; Validated; Region: PRK05582 405531010310 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 405531010311 active site 405531010312 interdomain interaction site; other site 405531010313 putative metal-binding site [ion binding]; other site 405531010314 nucleotide binding site [chemical binding]; other site 405531010315 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405531010316 domain I; other site 405531010317 DNA binding groove [nucleotide binding] 405531010318 phosphate binding site [ion binding]; other site 405531010319 domain II; other site 405531010320 domain III; other site 405531010321 nucleotide binding site [chemical binding]; other site 405531010322 catalytic site [active] 405531010323 domain IV; other site 405531010324 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405531010325 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405531010326 DNA protecting protein DprA; Region: dprA; TIGR00732 405531010327 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405531010328 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 405531010329 CoA binding domain; Region: CoA_binding; smart00881 405531010330 CoA-ligase; Region: Ligase_CoA; pfam00549 405531010331 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 405531010332 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 405531010333 CoA-ligase; Region: Ligase_CoA; pfam00549 405531010334 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 405531010335 RNA/DNA hybrid binding site [nucleotide binding]; other site 405531010336 active site 405531010337 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 405531010338 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 405531010339 GTP/Mg2+ binding site [chemical binding]; other site 405531010340 G4 box; other site 405531010341 G5 box; other site 405531010342 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 405531010343 G1 box; other site 405531010344 G1 box; other site 405531010345 GTP/Mg2+ binding site [chemical binding]; other site 405531010346 Switch I region; other site 405531010347 G2 box; other site 405531010348 G2 box; other site 405531010349 G3 box; other site 405531010350 G3 box; other site 405531010351 Switch II region; other site 405531010352 Switch II region; other site 405531010353 G4 box; other site 405531010354 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531010355 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531010356 Catalytic site [active] 405531010357 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 405531010358 Ribosomal protein L19 leader 405531010359 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 405531010360 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 405531010361 RimM N-terminal domain; Region: RimM; pfam01782 405531010362 PRC-barrel domain; Region: PRC; pfam05239 405531010363 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 405531010364 KH domain; Region: KH_4; pfam13083 405531010365 G-X-X-G motif; other site 405531010366 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 405531010367 signal recognition particle protein; Provisional; Region: PRK10867 405531010368 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 405531010369 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405531010370 P loop; other site 405531010371 GTP binding site [chemical binding]; other site 405531010372 Signal peptide binding domain; Region: SRP_SPB; pfam02978 405531010373 putative DNA-binding protein; Validated; Region: PRK00118 405531010374 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 405531010375 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 405531010376 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 405531010377 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405531010378 P loop; other site 405531010379 GTP binding site [chemical binding]; other site 405531010380 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405531010381 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405531010382 Walker A/P-loop; other site 405531010383 ATP binding site [chemical binding]; other site 405531010384 Q-loop/lid; other site 405531010385 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 405531010386 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 405531010387 ABC transporter signature motif; other site 405531010388 Walker B; other site 405531010389 D-loop; other site 405531010390 H-loop/switch region; other site 405531010391 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 405531010392 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 405531010393 dimerization interface [polypeptide binding]; other site 405531010394 active site 405531010395 metal binding site [ion binding]; metal-binding site 405531010396 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 405531010397 dsRNA binding site [nucleotide binding]; other site 405531010398 acyl carrier protein; Provisional; Region: acpP; PRK00982 405531010399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 405531010400 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405531010401 NAD(P) binding site [chemical binding]; other site 405531010402 homotetramer interface [polypeptide binding]; other site 405531010403 homodimer interface [polypeptide binding]; other site 405531010404 active site 405531010405 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 405531010406 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405531010407 putative phosphate acyltransferase; Provisional; Region: PRK05331 405531010408 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 405531010409 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405531010410 active site 2 [active] 405531010411 active site 1 [active] 405531010412 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 405531010413 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 405531010414 generic binding surface II; other site 405531010415 ssDNA binding site; other site 405531010416 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531010417 ATP binding site [chemical binding]; other site 405531010418 putative Mg++ binding site [ion binding]; other site 405531010419 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531010420 nucleotide binding region [chemical binding]; other site 405531010421 ATP-binding site [chemical binding]; other site 405531010422 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 405531010423 DAK2 domain; Region: Dak2; pfam02734 405531010424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 405531010425 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 405531010426 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 405531010427 Thiamine pyrophosphokinase; Region: TPK; cd07995 405531010428 active site 405531010429 dimerization interface [polypeptide binding]; other site 405531010430 thiamine binding site [chemical binding]; other site 405531010431 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 405531010432 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405531010433 substrate binding site [chemical binding]; other site 405531010434 hexamer interface [polypeptide binding]; other site 405531010435 metal binding site [ion binding]; metal-binding site 405531010436 GTPase RsgA; Reviewed; Region: PRK00098 405531010437 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 405531010438 RNA binding site [nucleotide binding]; other site 405531010439 homodimer interface [polypeptide binding]; other site 405531010440 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405531010441 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405531010442 GTP/Mg2+ binding site [chemical binding]; other site 405531010443 G4 box; other site 405531010444 G5 box; other site 405531010445 G1 box; other site 405531010446 Switch I region; other site 405531010447 G2 box; other site 405531010448 G3 box; other site 405531010449 Switch II region; other site 405531010450 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 405531010451 Catalytic domain of Protein Kinases; Region: PKc; cd00180 405531010452 active site 405531010453 ATP binding site [chemical binding]; other site 405531010454 substrate binding site [chemical binding]; other site 405531010455 activation loop (A-loop); other site 405531010456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 405531010457 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405531010458 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405531010459 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 405531010460 Protein phosphatase 2C; Region: PP2C; pfam00481 405531010461 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 405531010462 active site 405531010463 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 405531010464 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531010465 FeS/SAM binding site; other site 405531010466 16S rRNA methyltransferase B; Provisional; Region: PRK14902 405531010467 NusB family; Region: NusB; pfam01029 405531010468 putative RNA binding site [nucleotide binding]; other site 405531010469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531010470 S-adenosylmethionine binding site [chemical binding]; other site 405531010471 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 405531010472 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 405531010473 putative active site [active] 405531010474 substrate binding site [chemical binding]; other site 405531010475 putative cosubstrate binding site; other site 405531010476 catalytic site [active] 405531010477 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 405531010478 substrate binding site [chemical binding]; other site 405531010479 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405531010480 active site 405531010481 catalytic residues [active] 405531010482 metal binding site [ion binding]; metal-binding site 405531010483 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 405531010484 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531010485 ATP binding site [chemical binding]; other site 405531010486 putative Mg++ binding site [ion binding]; other site 405531010487 helicase superfamily c-terminal domain; Region: HELICc; smart00490 405531010488 nucleotide binding region [chemical binding]; other site 405531010489 ATP-binding site [chemical binding]; other site 405531010490 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 405531010491 Flavoprotein; Region: Flavoprotein; pfam02441 405531010492 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 405531010493 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 405531010494 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405531010495 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 405531010496 catalytic site [active] 405531010497 G-X2-G-X-G-K; other site 405531010498 hypothetical protein; Provisional; Region: PRK04323 405531010499 hypothetical protein; Provisional; Region: PRK11820 405531010500 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 405531010501 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 405531010502 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 405531010503 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405531010504 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531010505 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405531010506 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531010507 motif II; other site 405531010508 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405531010509 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 405531010510 Domain of unknown function (DUF814); Region: DUF814; pfam05670 405531010511 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405531010512 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405531010513 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405531010514 active site 405531010515 DinB superfamily; Region: DinB_2; pfam12867 405531010516 YoqO-like protein; Region: YoqO; pfam14037 405531010517 YoqO-like protein; Region: YoqO; pfam14037 405531010518 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405531010519 Protein of unknown function (DUF2651); Region: DUF2651; pfam10852 405531010520 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531010521 active site 405531010522 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 405531010523 active site 405531010524 dimer interface [polypeptide binding]; other site 405531010525 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 405531010526 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 405531010527 heterodimer interface [polypeptide binding]; other site 405531010528 active site 405531010529 FMN binding site [chemical binding]; other site 405531010530 homodimer interface [polypeptide binding]; other site 405531010531 substrate binding site [chemical binding]; other site 405531010532 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 405531010533 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 405531010534 FAD binding pocket [chemical binding]; other site 405531010535 FAD binding motif [chemical binding]; other site 405531010536 phosphate binding motif [ion binding]; other site 405531010537 beta-alpha-beta structure motif; other site 405531010538 NAD binding pocket [chemical binding]; other site 405531010539 Iron coordination center [ion binding]; other site 405531010540 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 405531010541 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405531010542 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405531010543 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405531010544 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405531010545 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405531010546 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405531010547 IMP binding site; other site 405531010548 dimer interface [polypeptide binding]; other site 405531010549 interdomain contacts; other site 405531010550 partial ornithine binding site; other site 405531010551 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 405531010552 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 405531010553 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 405531010554 catalytic site [active] 405531010555 subunit interface [polypeptide binding]; other site 405531010556 dihydroorotase; Validated; Region: pyrC; PRK09357 405531010557 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405531010558 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 405531010559 active site 405531010560 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 405531010561 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405531010562 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405531010563 PyrR binding site 405531010564 uracil transporter; Provisional; Region: PRK10720 405531010565 PyrR binding site 405531010566 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 405531010567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531010568 active site 405531010569 PyrR binding site 405531010570 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 405531010571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531010572 RNA binding surface [nucleotide binding]; other site 405531010573 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405531010574 active site 405531010575 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 405531010576 lipoprotein signal peptidase; Provisional; Region: PRK14787 405531010577 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 405531010578 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 405531010579 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405531010580 active site 405531010581 HIGH motif; other site 405531010582 nucleotide binding site [chemical binding]; other site 405531010583 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405531010584 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405531010585 active site 405531010586 KMSKS motif; other site 405531010587 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 405531010588 tRNA binding surface [nucleotide binding]; other site 405531010589 anticodon binding site; other site 405531010590 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405531010591 DivIVA protein; Region: DivIVA; pfam05103 405531010592 DivIVA domain; Region: DivI1A_domain; TIGR03544 405531010593 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 405531010594 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 405531010595 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531010596 RNA binding surface [nucleotide binding]; other site 405531010597 YGGT family; Region: YGGT; pfam02325 405531010598 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 405531010599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 405531010600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405531010601 catalytic residue [active] 405531010602 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 405531010603 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 405531010604 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 405531010605 sporulation sigma factor SigG; Reviewed; Region: PRK08215 405531010606 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531010607 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531010608 DNA binding residues [nucleotide binding] 405531010609 sporulation sigma factor SigE; Reviewed; Region: PRK08301 405531010610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531010611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531010612 DNA binding residues [nucleotide binding] 405531010613 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 405531010614 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 405531010615 cell division protein FtsZ; Validated; Region: PRK09330 405531010616 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 405531010617 nucleotide binding site [chemical binding]; other site 405531010618 SulA interaction site; other site 405531010619 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 405531010620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405531010621 nucleotide binding site [chemical binding]; other site 405531010622 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 405531010623 Cell division protein FtsA; Region: FtsA; pfam14450 405531010624 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 405531010625 Cell division protein FtsQ; Region: FtsQ; pfam03799 405531010626 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 405531010627 FAD binding domain; Region: FAD_binding_4; pfam01565 405531010628 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405531010629 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 405531010630 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405531010631 active site 405531010632 homodimer interface [polypeptide binding]; other site 405531010633 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 405531010634 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 405531010635 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 405531010636 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405531010637 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405531010638 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 405531010639 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 405531010640 Mg++ binding site [ion binding]; other site 405531010641 putative catalytic motif [active] 405531010642 putative substrate binding site [chemical binding]; other site 405531010643 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405531010644 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405531010645 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405531010646 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405531010647 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 405531010648 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531010649 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531010650 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 405531010651 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531010652 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531010653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531010654 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 405531010655 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 405531010656 Cell division protein FtsL; Region: FtsL; cl11433 405531010657 MraW methylase family; Region: Methyltransf_5; pfam01795 405531010658 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 405531010659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 405531010660 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 405531010661 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 405531010662 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405531010663 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405531010664 hypothetical protein; Provisional; Region: PRK13688 405531010665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531010666 Coenzyme A binding pocket [chemical binding]; other site 405531010667 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405531010668 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405531010669 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 405531010670 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 405531010671 hypothetical protein; Provisional; Region: PRK13670 405531010672 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 405531010673 putative transposase OrfB; Reviewed; Region: PHA02517 405531010674 HTH-like domain; Region: HTH_21; pfam13276 405531010675 Integrase core domain; Region: rve; pfam00665 405531010676 Integrase core domain; Region: rve_2; pfam13333 405531010677 Homeodomain-like domain; Region: HTH_23; cl17451 405531010678 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 405531010679 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 405531010680 protein binding site [polypeptide binding]; other site 405531010681 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405531010682 hypothetical protein; Provisional; Region: PRK10279 405531010683 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 405531010684 active site 405531010685 nucleophile elbow; other site 405531010686 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 405531010687 Nucleoside recognition; Region: Gate; pfam07670 405531010688 Nucleoside recognition; Region: Gate; pfam07670 405531010689 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 405531010690 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 405531010691 active site 405531010692 (T/H)XGH motif; other site 405531010693 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 405531010694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531010695 S-adenosylmethionine binding site [chemical binding]; other site 405531010696 ylbH leader 405531010697 hypothetical protein; Provisional; Region: PRK02886 405531010698 Protein of unknown function (DUF964); Region: DUF964; pfam06133 405531010699 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531010700 catalytic core [active] 405531010701 YlbE-like protein; Region: YlbE; pfam14003 405531010702 Putative coat protein; Region: YlbD_coat; pfam14071 405531010703 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 405531010704 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 405531010705 YugN-like family; Region: YugN; pfam08868 405531010706 formamidase; Provisional; Region: amiF; PRK13287 405531010707 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 405531010708 multimer interface [polypeptide binding]; other site 405531010709 active site 405531010710 catalytic triad [active] 405531010711 dimer interface [polypeptide binding]; other site 405531010712 cytochrome c oxidase assembly factor CtaG; Region: caa3_CtaG; TIGR02737 405531010713 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 405531010714 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405531010715 Subunit I/III interface [polypeptide binding]; other site 405531010716 Subunit III/IV interface [polypeptide binding]; other site 405531010717 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405531010718 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405531010719 D-pathway; other site 405531010720 Putative ubiquinol binding site [chemical binding]; other site 405531010721 Low-spin heme (heme b) binding site [chemical binding]; other site 405531010722 Putative water exit pathway; other site 405531010723 Binuclear center (heme o3/CuB) [ion binding]; other site 405531010724 K-pathway; other site 405531010725 Putative proton exit pathway; other site 405531010726 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 405531010727 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 405531010728 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405531010729 Cytochrome c; Region: Cytochrom_C; pfam00034 405531010730 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 405531010731 UbiA prenyltransferase family; Region: UbiA; pfam01040 405531010732 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 405531010733 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 405531010734 pyruvate carboxylase; Reviewed; Region: PRK12999 405531010735 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405531010736 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405531010737 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405531010738 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 405531010739 active site 405531010740 catalytic residues [active] 405531010741 metal binding site [ion binding]; metal-binding site 405531010742 homodimer binding site [polypeptide binding]; other site 405531010743 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405531010744 carboxyltransferase (CT) interaction site; other site 405531010745 biotinylation site [posttranslational modification]; other site 405531010746 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 405531010747 hypothetical protein; Provisional; Region: PRK13666 405531010748 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 405531010749 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 405531010750 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 405531010751 putative active site [active] 405531010752 PhoH-like protein; Region: PhoH; pfam02562 405531010753 hypothetical protein; Provisional; Region: PRK06733 405531010754 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 405531010755 YlaH-like protein; Region: YlaH; pfam14036 405531010756 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 405531010757 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 405531010758 G1 box; other site 405531010759 putative GEF interaction site [polypeptide binding]; other site 405531010760 GTP/Mg2+ binding site [chemical binding]; other site 405531010761 Switch I region; other site 405531010762 G2 box; other site 405531010763 G3 box; other site 405531010764 Switch II region; other site 405531010765 G4 box; other site 405531010766 G5 box; other site 405531010767 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 405531010768 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 405531010769 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 405531010770 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 405531010771 active site 405531010772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 405531010773 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 405531010774 hypothetical protein; Provisional; Region: PRK04387 405531010775 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 405531010776 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405531010777 homodimer interface [polypeptide binding]; other site 405531010778 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531010779 catalytic residue [active] 405531010780 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405531010781 transglutaminase; Provisional; Region: tgl; PRK03187 405531010782 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405531010783 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405531010784 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 405531010785 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405531010786 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 405531010787 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 405531010788 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531010789 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405531010790 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405531010791 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405531010792 E3 interaction surface; other site 405531010793 lipoyl attachment site [posttranslational modification]; other site 405531010794 e3 binding domain; Region: E3_binding; pfam02817 405531010795 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405531010796 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405531010797 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405531010798 alpha subunit interface [polypeptide binding]; other site 405531010799 TPP binding site [chemical binding]; other site 405531010800 heterodimer interface [polypeptide binding]; other site 405531010801 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405531010802 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 405531010803 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405531010804 TPP-binding site [chemical binding]; other site 405531010805 heterodimer interface [polypeptide binding]; other site 405531010806 tetramer interface [polypeptide binding]; other site 405531010807 phosphorylation loop region [posttranslational modification] 405531010808 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405531010809 active site 405531010810 catalytic residues [active] 405531010811 metal binding site [ion binding]; metal-binding site 405531010812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531010813 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531010814 active site 405531010815 motif I; other site 405531010816 motif II; other site 405531010817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531010818 hypothetical protein; Provisional; Region: PRK13667 405531010819 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 405531010820 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531010821 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 405531010822 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405531010823 TrkA-N domain; Region: TrkA_N; pfam02254 405531010824 TrkA-C domain; Region: TrkA_C; pfam02080 405531010825 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405531010826 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405531010827 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 405531010828 metal binding site [ion binding]; metal-binding site 405531010829 putative dimer interface [polypeptide binding]; other site 405531010830 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 405531010831 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 405531010832 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 405531010833 trimer interface [polypeptide binding]; other site 405531010834 active site 405531010835 substrate binding site [chemical binding]; other site 405531010836 CoA binding site [chemical binding]; other site 405531010837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531010838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531010839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531010840 dimerization interface [polypeptide binding]; other site 405531010841 FOG: CBS domain [General function prediction only]; Region: COG0517 405531010842 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 405531010843 Antirepressor AbbA; Region: AbbA_antirepres; pfam14156 405531010844 Protein of unknown function (DUF458); Region: DUF458; pfam04308 405531010845 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 405531010846 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 405531010847 catalytic residues [active] 405531010848 Protein of unknown function (DUF3993); Region: DUF3993; pfam13158 405531010849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531010850 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 405531010851 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 405531010852 short chain dehydrogenase; Provisional; Region: PRK07677 405531010853 NAD(P) binding site [chemical binding]; other site 405531010854 substrate binding site [chemical binding]; other site 405531010855 homotetramer interface [polypeptide binding]; other site 405531010856 active site 405531010857 homodimer interface [polypeptide binding]; other site 405531010858 phosphodiesterase YaeI; Provisional; Region: PRK11340 405531010859 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 405531010860 putative active site [active] 405531010861 putative metal binding site [ion binding]; other site 405531010862 potential frameshift: common BLAST hit: gi|218232962|ref|YP_002368796.1| polyphosphate kinase 405531010863 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 405531010864 Polyphosphate kinase C-terminal domain; Region: PP_kinase_C; pfam13090 405531010865 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 405531010866 putative domain interface [polypeptide binding]; other site 405531010867 putative active site [active] 405531010868 catalytic site [active] 405531010869 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 405531010870 putative domain interface [polypeptide binding]; other site 405531010871 putative active site [active] 405531010872 catalytic site [active] 405531010873 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 405531010874 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 405531010875 exopolyphosphatase; Region: exo_poly_only; TIGR03706 405531010876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405531010877 nucleotide binding site [chemical binding]; other site 405531010878 YkyB-like protein; Region: YkyB; pfam14177 405531010879 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 405531010880 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531010881 I-site; other site 405531010882 active site 405531010883 metal binding site [ion binding]; metal-binding site 405531010884 Phage lysis protein, holin; Region: Phage_holin; cl04675 405531010885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531010886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531010887 putative substrate translocation pore; other site 405531010888 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531010889 Transcriptional regulator PadR-like family; Region: PadR; cl17335 405531010890 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 405531010891 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 405531010892 THF binding site; other site 405531010893 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 405531010894 substrate binding site [chemical binding]; other site 405531010895 THF binding site; other site 405531010896 zinc-binding site [ion binding]; other site 405531010897 Competence protein J (ComJ); Region: ComJ; pfam11033 405531010898 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 405531010899 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 405531010900 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 405531010901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531010902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531010903 dimer interface [polypeptide binding]; other site 405531010904 phosphorylation site [posttranslational modification] 405531010905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531010906 ATP binding site [chemical binding]; other site 405531010907 Mg2+ binding site [ion binding]; other site 405531010908 G-X-G motif; other site 405531010909 aminotransferase A; Validated; Region: PRK07683 405531010910 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531010911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531010912 homodimer interface [polypeptide binding]; other site 405531010913 catalytic residue [active] 405531010914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531010915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531010916 DNA binding site [nucleotide binding] 405531010917 domain linker motif; other site 405531010918 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 405531010919 putative dimerization interface [polypeptide binding]; other site 405531010920 putative ligand binding site [chemical binding]; other site 405531010921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405531010922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531010923 dimer interface [polypeptide binding]; other site 405531010924 conserved gate region; other site 405531010925 putative PBP binding loops; other site 405531010926 ABC-ATPase subunit interface; other site 405531010927 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531010928 dimer interface [polypeptide binding]; other site 405531010929 conserved gate region; other site 405531010930 putative PBP binding loops; other site 405531010931 ABC-ATPase subunit interface; other site 405531010932 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 405531010933 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405531010934 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 405531010935 homodimer interface [polypeptide binding]; other site 405531010936 maltodextrin glucosidase; Provisional; Region: PRK10785 405531010937 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 405531010938 active site 405531010939 homodimer interface [polypeptide binding]; other site 405531010940 catalytic site [active] 405531010941 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 405531010942 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 405531010943 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405531010944 Ca binding site [ion binding]; other site 405531010945 active site 405531010946 catalytic site [active] 405531010947 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405531010948 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405531010949 Walker A/P-loop; other site 405531010950 ATP binding site [chemical binding]; other site 405531010951 Q-loop/lid; other site 405531010952 ABC transporter signature motif; other site 405531010953 Walker B; other site 405531010954 D-loop; other site 405531010955 H-loop/switch region; other site 405531010956 TOBE domain; Region: TOBE_2; pfam08402 405531010957 hypothetical protein; Provisional; Region: PRK06720 405531010958 NAD(P) binding site [chemical binding]; other site 405531010959 RDD family; Region: RDD; pfam06271 405531010960 Protein of unknown function (DUF3997); Region: DUF3997; pfam13162 405531010961 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 405531010962 Predicted ATPase [General function prediction only]; Region: COG3910 405531010963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531010964 Walker A/P-loop; other site 405531010965 ATP binding site [chemical binding]; other site 405531010966 Q-loop/lid; other site 405531010967 ABC transporter signature motif; other site 405531010968 Walker B; other site 405531010969 D-loop; other site 405531010970 H-loop/switch region; other site 405531010971 putative acyltransferase; Provisional; Region: PRK05790 405531010972 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405531010973 dimer interface [polypeptide binding]; other site 405531010974 active site 405531010975 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405531010976 nudix motif; other site 405531010977 Protein of unknown function (DUF3928); Region: DUF3928; pfam13065 405531010978 hypothetical protein; Validated; Region: PRK07668 405531010979 hypothetical protein; Validated; Region: PRK07668 405531010980 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531010981 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531010982 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 405531010983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531010984 NAD(P) binding site [chemical binding]; other site 405531010985 active site 405531010986 YvrJ protein family; Region: YvrJ; pfam12841 405531010987 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 405531010988 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 405531010989 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 405531010990 Phosphotransferase enzyme family; Region: APH; pfam01636 405531010991 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405531010992 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 405531010993 putative active site [active] 405531010994 catalytic triad [active] 405531010995 putative dimer interface [polypeptide binding]; other site 405531010996 transaminase; Reviewed; Region: PRK08068 405531010997 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531010998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531010999 homodimer interface [polypeptide binding]; other site 405531011000 catalytic residue [active] 405531011001 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 405531011002 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 405531011003 dimer interface [polypeptide binding]; other site 405531011004 active site 405531011005 catalytic residue [active] 405531011006 metal binding site [ion binding]; metal-binding site 405531011007 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase; Reviewed; Region: mtnX; PRK09552 405531011008 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 405531011009 methylthioribulose-1-phosphate dehydratase; Reviewed; Region: mtnB; PRK06754 405531011010 intersubunit interface [polypeptide binding]; other site 405531011011 active site 405531011012 Zn2+ binding site [ion binding]; other site 405531011013 ARD/ARD' family; Region: ARD; pfam03079 405531011014 Cupin domain; Region: Cupin_2; pfam07883 405531011015 Protein of unknown function (DUF3909); Region: DUF3909; pfam13077 405531011016 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405531011017 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405531011018 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405531011019 Beta-lactamase; Region: Beta-lactamase; pfam00144 405531011020 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531011021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531011022 metal binding site [ion binding]; metal-binding site 405531011023 active site 405531011024 I-site; other site 405531011025 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405531011026 dimer interface [polypeptide binding]; other site 405531011027 FMN binding site [chemical binding]; other site 405531011028 Protein of unknown function (DUF3915); Region: DUF3915; pfam13054 405531011029 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405531011030 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405531011031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405531011032 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405531011033 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405531011034 dimerization domain swap beta strand [polypeptide binding]; other site 405531011035 regulatory protein interface [polypeptide binding]; other site 405531011036 active site 405531011037 regulatory phosphorylation site [posttranslational modification]; other site 405531011038 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405531011039 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 405531011040 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405531011041 active site turn [active] 405531011042 phosphorylation site [posttranslational modification] 405531011043 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405531011044 HPr interaction site; other site 405531011045 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405531011046 active site 405531011047 phosphorylation site [posttranslational modification] 405531011048 transcriptional antiterminator BglG; Provisional; Region: PRK09772 405531011049 CAT RNA binding domain; Region: CAT_RBD; smart01061 405531011050 PRD domain; Region: PRD; pfam00874 405531011051 PRD domain; Region: PRD; pfam00874 405531011052 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531011053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531011054 active site 405531011055 motif I; other site 405531011056 motif II; other site 405531011057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531011058 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405531011059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531011060 DNA-binding site [nucleotide binding]; DNA binding site 405531011061 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 405531011062 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405531011063 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405531011064 active site 405531011065 trimer interface [polypeptide binding]; other site 405531011066 allosteric site; other site 405531011067 active site lid [active] 405531011068 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405531011069 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405531011070 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405531011071 active site 405531011072 dimer interface [polypeptide binding]; other site 405531011073 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405531011074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531011075 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 405531011076 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 405531011077 Domain of unknown function (DUF309); Region: DUF309; pfam03745 405531011078 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531011079 Coenzyme A binding pocket [chemical binding]; other site 405531011080 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 405531011081 active site 405531011082 Predicted secreted protein [Function unknown]; Region: COG4086 405531011083 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 405531011084 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531011085 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 405531011086 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405531011087 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531011088 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 405531011089 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405531011090 stage V sporulation protein AD; Validated; Region: PRK08304 405531011091 stage V sporulation protein AD; Provisional; Region: PRK12404 405531011092 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405531011093 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 405531011094 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 405531011095 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 405531011096 Na2 binding site [ion binding]; other site 405531011097 putative substrate binding site 1 [chemical binding]; other site 405531011098 Na binding site 1 [ion binding]; other site 405531011099 putative substrate binding site 2 [chemical binding]; other site 405531011100 sporulation sigma factor SigF; Validated; Region: PRK05572 405531011101 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531011102 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405531011103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531011104 DNA binding residues [nucleotide binding] 405531011105 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 405531011106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531011107 ATP binding site [chemical binding]; other site 405531011108 Mg2+ binding site [ion binding]; other site 405531011109 G-X-G motif; other site 405531011110 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 405531011111 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 405531011112 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531011113 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405531011114 Predicted transcriptional regulators [Transcription]; Region: COG1725 405531011115 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531011116 DNA-binding site [nucleotide binding]; DNA binding site 405531011117 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531011118 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531011119 Walker A/P-loop; other site 405531011120 ATP binding site [chemical binding]; other site 405531011121 Q-loop/lid; other site 405531011122 ABC transporter signature motif; other site 405531011123 Walker B; other site 405531011124 D-loop; other site 405531011125 H-loop/switch region; other site 405531011126 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405531011127 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405531011128 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405531011129 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531011130 MarR family; Region: MarR; pfam01047 405531011131 MarR family; Region: MarR_2; cl17246 405531011132 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 405531011133 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405531011134 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 405531011135 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 405531011136 oligomer interface [polypeptide binding]; other site 405531011137 metal binding site [ion binding]; metal-binding site 405531011138 metal binding site [ion binding]; metal-binding site 405531011139 putative Cl binding site [ion binding]; other site 405531011140 aspartate ring; other site 405531011141 basic sphincter; other site 405531011142 hydrophobic gate; other site 405531011143 periplasmic entrance; other site 405531011144 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 405531011145 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405531011146 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405531011147 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405531011148 purine nucleoside phosphorylase; Provisional; Region: PRK08202 405531011149 phosphopentomutase; Provisional; Region: PRK05362 405531011150 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 405531011151 YtkA-like; Region: YtkA; pfam13115 405531011152 YtkA-like; Region: YtkA; pfam13115 405531011153 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405531011154 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405531011155 active site 405531011156 Int/Topo IB signature motif; other site 405531011157 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 405531011158 ferric uptake regulator; Provisional; Region: fur; PRK09462 405531011159 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405531011160 metal binding site 2 [ion binding]; metal-binding site 405531011161 putative DNA binding helix; other site 405531011162 metal binding site 1 [ion binding]; metal-binding site 405531011163 dimer interface [polypeptide binding]; other site 405531011164 structural Zn2+ binding site [ion binding]; other site 405531011165 stage II sporulation protein M; Region: spo_II_M; TIGR02831 405531011166 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531011167 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531011168 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405531011169 dimer interface [polypeptide binding]; other site 405531011170 ADP-ribose binding site [chemical binding]; other site 405531011171 active site 405531011172 nudix motif; other site 405531011173 metal binding site [ion binding]; metal-binding site 405531011174 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 405531011175 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531011176 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531011177 active site 405531011178 catalytic tetrad [active] 405531011179 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531011180 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531011181 active site 405531011182 catalytic tetrad [active] 405531011183 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 405531011184 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 405531011185 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405531011186 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 405531011187 putative active site [active] 405531011188 putative metal binding site [ion binding]; other site 405531011189 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405531011190 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 405531011191 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531011192 Predicted permease [General function prediction only]; Region: COG2056 405531011193 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 405531011194 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 405531011195 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531011196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531011197 DNA binding site [nucleotide binding] 405531011198 domain linker motif; other site 405531011199 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 405531011200 dimerization interface [polypeptide binding]; other site 405531011201 ligand binding site [chemical binding]; other site 405531011202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531011203 Coenzyme A binding pocket [chemical binding]; other site 405531011204 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 405531011205 Protein of unknown function (DUF2552); Region: DUF2552; pfam10827 405531011206 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 405531011207 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 405531011208 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 405531011209 catalytic motif [active] 405531011210 Zn binding site [ion binding]; other site 405531011211 RibD C-terminal domain; Region: RibD_C; cl17279 405531011212 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 405531011213 Lumazine binding domain; Region: Lum_binding; pfam00677 405531011214 Lumazine binding domain; Region: Lum_binding; pfam00677 405531011215 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 405531011216 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 405531011217 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 405531011218 dimerization interface [polypeptide binding]; other site 405531011219 active site 405531011220 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 405531011221 homopentamer interface [polypeptide binding]; other site 405531011222 active site 405531011223 biotin synthase; Validated; Region: PRK06256 405531011224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531011225 FeS/SAM binding site; other site 405531011226 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 405531011227 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 405531011228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531011229 S-adenosylmethionine binding site [chemical binding]; other site 405531011230 pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738 405531011231 Protein of unknown function (DUF452); Region: DUF452; cl01062 405531011232 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405531011233 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405531011234 substrate-cofactor binding pocket; other site 405531011235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011236 catalytic residue [active] 405531011237 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 405531011238 AAA domain; Region: AAA_26; pfam13500 405531011239 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 405531011240 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531011241 inhibitor-cofactor binding pocket; inhibition site 405531011242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011243 catalytic residue [active] 405531011244 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405531011245 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405531011246 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK09418 405531011247 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405531011248 active site 405531011249 metal binding site [ion binding]; metal-binding site 405531011250 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405531011251 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 405531011252 active site 405531011253 catalytic triad [active] 405531011254 oxyanion hole [active] 405531011255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531011256 dimerization interface [polypeptide binding]; other site 405531011257 putative DNA binding site [nucleotide binding]; other site 405531011258 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531011259 putative Zn2+ binding site [ion binding]; other site 405531011260 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 405531011261 ornithine carbamoyltransferase; Provisional; Region: PRK00779 405531011262 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405531011263 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405531011264 acetylornithine aminotransferase; Provisional; Region: argD; PRK02936 405531011265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531011266 inhibitor-cofactor binding pocket; inhibition site 405531011267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011268 catalytic residue [active] 405531011269 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 405531011270 nucleotide binding site [chemical binding]; other site 405531011271 N-acetyl-L-glutamate binding site [chemical binding]; other site 405531011272 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 405531011273 heterotetramer interface [polypeptide binding]; other site 405531011274 active site pocket [active] 405531011275 cleavage site 405531011276 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 405531011277 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405531011278 YqzH-like protein; Region: YqzH; pfam14164 405531011279 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 405531011280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531011281 NAD(P) binding site [chemical binding]; other site 405531011282 active site 405531011283 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531011284 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07679 405531011285 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 405531011286 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 405531011287 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 405531011288 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 405531011289 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405531011290 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 405531011291 putative L-serine binding site [chemical binding]; other site 405531011292 ribonuclease Z; Region: RNase_Z; TIGR02651 405531011293 Protein of unknown function (DUF3932); Region: DUF3932; pfam13068 405531011294 ykoK leader 405531011295 magnesium-transporting ATPase; Provisional; Region: PRK15122 405531011296 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 405531011297 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405531011298 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405531011299 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 405531011300 Soluble P-type ATPase [General function prediction only]; Region: COG4087 405531011301 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405531011302 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405531011303 MgtC family; Region: MgtC; pfam02308 405531011304 DNA polymerase IV; Validated; Region: PRK01810 405531011305 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 405531011306 active site 405531011307 DNA binding site [nucleotide binding] 405531011308 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405531011309 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 405531011310 peptidase T-like protein; Region: PepT-like; TIGR01883 405531011311 metal binding site [ion binding]; metal-binding site 405531011312 putative dimer interface [polypeptide binding]; other site 405531011313 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531011314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531011315 Protein of unknown function (DUF3894); Region: DUF3894; pfam13033 405531011316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405531011317 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405531011318 Predicted membrane protein [Function unknown]; Region: COG4129 405531011319 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 405531011320 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 405531011321 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405531011322 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405531011323 Walker A/P-loop; other site 405531011324 ATP binding site [chemical binding]; other site 405531011325 Q-loop/lid; other site 405531011326 ABC transporter signature motif; other site 405531011327 Walker B; other site 405531011328 D-loop; other site 405531011329 H-loop/switch region; other site 405531011330 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405531011331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531011332 dimer interface [polypeptide binding]; other site 405531011333 conserved gate region; other site 405531011334 putative PBP binding loops; other site 405531011335 ABC-ATPase subunit interface; other site 405531011336 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 405531011337 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405531011338 substrate binding pocket [chemical binding]; other site 405531011339 membrane-bound complex binding site; other site 405531011340 hinge residues; other site 405531011341 Disulphide isomerase; Region: Disulph_isomer; pfam06491 405531011342 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 405531011343 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 405531011344 nudix motif; other site 405531011345 Predicted membrane protein [Function unknown]; Region: COG2323 405531011346 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 405531011347 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 405531011348 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405531011349 E3 interaction surface; other site 405531011350 lipoyl attachment site [posttranslational modification]; other site 405531011351 e3 binding domain; Region: E3_binding; pfam02817 405531011352 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405531011353 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 405531011354 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 405531011355 alpha subunit interface [polypeptide binding]; other site 405531011356 TPP binding site [chemical binding]; other site 405531011357 heterodimer interface [polypeptide binding]; other site 405531011358 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405531011359 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 405531011360 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 405531011361 tetramer interface [polypeptide binding]; other site 405531011362 TPP-binding site [chemical binding]; other site 405531011363 heterodimer interface [polypeptide binding]; other site 405531011364 phosphorylation loop region [posttranslational modification] 405531011365 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 405531011366 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405531011367 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531011368 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405531011369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405531011370 nucleotide binding site [chemical binding]; other site 405531011371 Acetokinase family; Region: Acetate_kinase; cl17229 405531011372 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 405531011373 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405531011374 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 405531011375 NAD binding site [chemical binding]; other site 405531011376 Phe binding site; other site 405531011377 phosphate butyryltransferase; Validated; Region: PRK07742 405531011378 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 405531011379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531011380 putative active site [active] 405531011381 heme pocket [chemical binding]; other site 405531011382 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531011383 putative active site [active] 405531011384 heme pocket [chemical binding]; other site 405531011385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531011386 Walker A motif; other site 405531011387 ATP binding site [chemical binding]; other site 405531011388 Walker B motif; other site 405531011389 arginine finger; other site 405531011390 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405531011391 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 405531011392 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405531011393 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405531011394 active site 405531011395 catalytic site [active] 405531011396 metal binding site [ion binding]; metal-binding site 405531011397 dimer interface [polypeptide binding]; other site 405531011398 YycC-like protein; Region: YycC; pfam14174 405531011399 hypothetical protein; Provisional; Region: PRK06770 405531011400 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 405531011401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531011402 active site 405531011403 phosphorylation site [posttranslational modification] 405531011404 intermolecular recognition site; other site 405531011405 dimerization interface [polypeptide binding]; other site 405531011406 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 405531011407 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 405531011408 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405531011409 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 405531011410 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 405531011411 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405531011412 Walker A/P-loop; other site 405531011413 ATP binding site [chemical binding]; other site 405531011414 Q-loop/lid; other site 405531011415 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405531011416 ABC transporter signature motif; other site 405531011417 Walker B; other site 405531011418 D-loop; other site 405531011419 H-loop/switch region; other site 405531011420 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405531011421 arginine repressor; Provisional; Region: PRK04280 405531011422 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405531011423 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 405531011424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531011425 RNA binding surface [nucleotide binding]; other site 405531011426 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 405531011427 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 405531011428 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 405531011429 TPP-binding site; other site 405531011430 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405531011431 PYR/PP interface [polypeptide binding]; other site 405531011432 dimer interface [polypeptide binding]; other site 405531011433 TPP binding site [chemical binding]; other site 405531011434 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405531011435 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405531011436 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405531011437 substrate binding pocket [chemical binding]; other site 405531011438 chain length determination region; other site 405531011439 substrate-Mg2+ binding site; other site 405531011440 catalytic residues [active] 405531011441 aspartate-rich region 1; other site 405531011442 active site lid residues [active] 405531011443 aspartate-rich region 2; other site 405531011444 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK14063 405531011445 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 405531011446 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 405531011447 generic binding surface II; other site 405531011448 generic binding surface I; other site 405531011449 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 405531011450 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405531011451 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405531011452 homodimer interface [polypeptide binding]; other site 405531011453 NADP binding site [chemical binding]; other site 405531011454 substrate binding site [chemical binding]; other site 405531011455 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 405531011456 putative RNA binding site [nucleotide binding]; other site 405531011457 Asp23 family; Region: Asp23; pfam03780 405531011458 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 405531011459 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405531011460 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405531011461 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405531011462 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 405531011463 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405531011464 carboxyltransferase (CT) interaction site; other site 405531011465 biotinylation site [posttranslational modification]; other site 405531011466 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 405531011467 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 405531011468 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 405531011469 stage III sporulation protein AE; Region: spore_III_AE; TIGR02829 405531011470 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 405531011471 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 405531011472 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 405531011473 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 405531011474 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531011475 Walker A motif; other site 405531011476 ATP binding site [chemical binding]; other site 405531011477 Walker B motif; other site 405531011478 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 405531011479 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531011480 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531011481 elongation factor P; Validated; Region: PRK00529 405531011482 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405531011483 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405531011484 RNA binding site [nucleotide binding]; other site 405531011485 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405531011486 RNA binding site [nucleotide binding]; other site 405531011487 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405531011488 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405531011489 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405531011490 active site 405531011491 Dehydroquinase class II; Region: DHquinase_II; pfam01220 405531011492 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 405531011493 trimer interface [polypeptide binding]; other site 405531011494 active site 405531011495 dimer interface [polypeptide binding]; other site 405531011496 Conserved membrane protein YqhR; Region: YqhR; pfam11085 405531011497 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 405531011498 Carbon starvation protein CstA; Region: CstA; pfam02554 405531011499 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 405531011500 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405531011501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531011502 motif II; other site 405531011503 manganese transport transcriptional regulator; Provisional; Region: PRK03902 405531011504 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 405531011505 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 405531011506 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 405531011507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531011508 FeS/SAM binding site; other site 405531011509 Predicted transcriptional regulators [Transcription]; Region: COG1695 405531011510 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405531011511 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405531011512 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531011513 active site residue [active] 405531011514 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531011515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531011516 DNA binding site [nucleotide binding] 405531011517 domain linker motif; other site 405531011518 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405531011519 putative dimerization interface [polypeptide binding]; other site 405531011520 putative ligand binding site [chemical binding]; other site 405531011521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531011522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531011523 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531011524 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531011525 Protein of unknown function (DUF3975); Region: DUF3975; pfam13126 405531011526 Protein of unknown function (DUF3929); Region: DUF3929; pfam13066 405531011527 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405531011528 tetramer interface [polypeptide binding]; other site 405531011529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011530 catalytic residue [active] 405531011531 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 405531011532 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405531011533 tetramer interface [polypeptide binding]; other site 405531011534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011535 catalytic residue [active] 405531011536 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 405531011537 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 405531011538 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 405531011539 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405531011540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531011541 ATP binding site [chemical binding]; other site 405531011542 putative Mg++ binding site [ion binding]; other site 405531011543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531011544 nucleotide binding region [chemical binding]; other site 405531011545 ATP-binding site [chemical binding]; other site 405531011546 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 405531011547 YqzE-like protein; Region: YqzE; pfam14038 405531011548 shikimate kinase; Reviewed; Region: aroK; PRK00131 405531011549 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 405531011550 ADP binding site [chemical binding]; other site 405531011551 magnesium binding site [ion binding]; other site 405531011552 putative shikimate binding site; other site 405531011553 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 405531011554 ComG operon protein 7; Region: ComGG; pfam14173 405531011555 Probable transposase; Region: OrfB_IS605; pfam01385 405531011556 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 405531011557 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 405531011558 Transposase IS200 like; Region: Y1_Tnp; pfam01797 405531011559 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 405531011560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531011561 putative DNA binding site [nucleotide binding]; other site 405531011562 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 405531011563 putative Zn2+ binding site [ion binding]; other site 405531011564 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 405531011565 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 405531011566 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405531011567 Protein of unknown function (DUF3912); Region: DUF3912; pfam13051 405531011568 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818 405531011569 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405531011570 Protein of unknown function (DUF3966); Region: DUF3966; pfam13110 405531011571 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 405531011572 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405531011573 active site 405531011574 homodimer interface [polypeptide binding]; other site 405531011575 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 405531011576 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 405531011577 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 405531011578 substrate binding pocket [chemical binding]; other site 405531011579 dimer interface [polypeptide binding]; other site 405531011580 inhibitor binding site; inhibition site 405531011581 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 405531011582 B12 binding site [chemical binding]; other site 405531011583 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 405531011584 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 405531011585 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 405531011586 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 405531011587 FAD binding site [chemical binding]; other site 405531011588 cystathionine gamma-synthase; Reviewed; Region: PRK08247 405531011589 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405531011590 homodimer interface [polypeptide binding]; other site 405531011591 substrate-cofactor binding pocket; other site 405531011592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011593 catalytic residue [active] 405531011594 cystathionine beta-lyase; Provisional; Region: PRK08064 405531011595 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405531011596 homodimer interface [polypeptide binding]; other site 405531011597 substrate-cofactor binding pocket; other site 405531011598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011599 catalytic residue [active] 405531011600 Isochorismatase family; Region: Isochorismatase; pfam00857 405531011601 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405531011602 catalytic triad [active] 405531011603 conserved cis-peptide bond; other site 405531011604 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531011605 dimerization interface [polypeptide binding]; other site 405531011606 putative DNA binding site [nucleotide binding]; other site 405531011607 putative Zn2+ binding site [ion binding]; other site 405531011608 Uncharacterized conserved protein [Function unknown]; Region: COG1565 405531011609 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405531011610 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 405531011611 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 405531011612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405531011613 nucleotide binding site [chemical binding]; other site 405531011614 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 405531011615 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 405531011616 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 405531011617 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405531011618 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 405531011619 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 405531011620 active site 405531011621 Substrate binding site; other site 405531011622 Mg++ binding site; other site 405531011623 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405531011624 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 405531011625 active site 405531011626 metal binding site [ion binding]; metal-binding site 405531011627 substrate binding site [chemical binding]; other site 405531011628 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 405531011629 PhoU domain; Region: PhoU; pfam01895 405531011630 PhoU domain; Region: PhoU; pfam01895 405531011631 phosphate transporter ATP-binding protein; Provisional; Region: PRK14238 405531011632 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405531011633 Walker A/P-loop; other site 405531011634 ATP binding site [chemical binding]; other site 405531011635 Q-loop/lid; other site 405531011636 ABC transporter signature motif; other site 405531011637 Walker B; other site 405531011638 D-loop; other site 405531011639 H-loop/switch region; other site 405531011640 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 405531011641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531011642 dimer interface [polypeptide binding]; other site 405531011643 conserved gate region; other site 405531011644 putative PBP binding loops; other site 405531011645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 405531011646 ABC-ATPase subunit interface; other site 405531011647 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 405531011648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531011649 dimer interface [polypeptide binding]; other site 405531011650 conserved gate region; other site 405531011651 putative PBP binding loops; other site 405531011652 ABC-ATPase subunit interface; other site 405531011653 PBP superfamily domain; Region: PBP_like_2; cl17296 405531011654 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531011655 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531011656 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531011657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531011658 putative substrate translocation pore; other site 405531011659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531011660 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405531011661 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405531011662 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405531011663 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 405531011664 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 405531011665 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405531011666 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405531011667 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405531011668 metal binding site 2 [ion binding]; metal-binding site 405531011669 putative DNA binding helix; other site 405531011670 metal binding site 1 [ion binding]; metal-binding site 405531011671 dimer interface [polypeptide binding]; other site 405531011672 structural Zn2+ binding site [ion binding]; other site 405531011673 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405531011674 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531011675 ABC-ATPase subunit interface; other site 405531011676 dimer interface [polypeptide binding]; other site 405531011677 putative PBP binding regions; other site 405531011678 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 405531011679 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405531011680 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531011681 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531011682 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531011683 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 405531011684 endonuclease IV; Provisional; Region: PRK01060 405531011685 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405531011686 AP (apurinic/apyrimidinic) site pocket; other site 405531011687 DNA interaction; other site 405531011688 Metal-binding active site; metal-binding site 405531011689 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405531011690 DEAD-like helicases superfamily; Region: DEXDc; smart00487 405531011691 ATP binding site [chemical binding]; other site 405531011692 Mg++ binding site [ion binding]; other site 405531011693 motif III; other site 405531011694 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531011695 nucleotide binding region [chemical binding]; other site 405531011696 ATP-binding site [chemical binding]; other site 405531011697 YqfQ-like protein; Region: YqfQ; pfam14181 405531011698 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 405531011699 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 405531011700 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405531011701 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405531011702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 405531011703 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405531011704 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405531011705 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 405531011706 Family of unknown function (DUF633); Region: DUF633; pfam04816 405531011707 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405531011708 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405531011709 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 405531011710 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 405531011711 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405531011712 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531011713 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405531011714 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531011715 DNA binding residues [nucleotide binding] 405531011716 DNA primase; Validated; Region: dnaG; PRK05667 405531011717 CHC2 zinc finger; Region: zf-CHC2; pfam01807 405531011718 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 405531011719 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 405531011720 active site 405531011721 metal binding site [ion binding]; metal-binding site 405531011722 interdomain interaction site; other site 405531011723 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 405531011724 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 405531011725 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 405531011726 PEP synthetase regulatory protein; Provisional; Region: PRK05339 405531011727 HTH domain; Region: HTH_11; pfam08279 405531011728 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 405531011729 FOG: CBS domain [General function prediction only]; Region: COG0517 405531011730 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 405531011731 Recombination protein O N terminal; Region: RecO_N; pfam11967 405531011732 Recombination protein O C terminal; Region: RecO_C; pfam02565 405531011733 YqzL-like protein; Region: YqzL; pfam14006 405531011734 GTPase Era; Reviewed; Region: era; PRK00089 405531011735 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 405531011736 G1 box; other site 405531011737 GTP/Mg2+ binding site [chemical binding]; other site 405531011738 Switch I region; other site 405531011739 G2 box; other site 405531011740 Switch II region; other site 405531011741 G3 box; other site 405531011742 G4 box; other site 405531011743 G5 box; other site 405531011744 KH domain; Region: KH_2; pfam07650 405531011745 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405531011746 active site 405531011747 catalytic motif [active] 405531011748 Zn binding site [ion binding]; other site 405531011749 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 405531011750 metal-binding heat shock protein; Provisional; Region: PRK00016 405531011751 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 405531011752 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 405531011753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531011754 Zn2+ binding site [ion binding]; other site 405531011755 Mg2+ binding site [ion binding]; other site 405531011756 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405531011757 PhoH-like protein; Region: PhoH; pfam02562 405531011758 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 405531011759 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 405531011760 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 405531011761 potential frameshift: common BLAST hit: gi|30022386|ref|NP_834017.1| cytoplasmic protein 405531011762 Domain of unknown function (DUF4253); Region: DUF4253; pfam14062 405531011763 Yqey-like protein; Region: YqeY; pfam09424 405531011764 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 405531011765 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 405531011766 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405531011767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531011768 FeS/SAM binding site; other site 405531011769 TRAM domain; Region: TRAM; cl01282 405531011770 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 405531011771 RNA methyltransferase, RsmE family; Region: TIGR00046 405531011772 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 405531011773 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531011774 S-adenosylmethionine binding site [chemical binding]; other site 405531011775 chaperone protein DnaJ; Provisional; Region: PRK14280 405531011776 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405531011777 HSP70 interaction site [polypeptide binding]; other site 405531011778 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 405531011779 substrate binding site [polypeptide binding]; other site 405531011780 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405531011781 Zn binding sites [ion binding]; other site 405531011782 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405531011783 dimer interface [polypeptide binding]; other site 405531011784 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 405531011785 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 405531011786 nucleotide binding site [chemical binding]; other site 405531011787 NEF interaction site [polypeptide binding]; other site 405531011788 SBD interface [polypeptide binding]; other site 405531011789 GrpE; Region: GrpE; pfam01025 405531011790 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 405531011791 dimer interface [polypeptide binding]; other site 405531011792 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 405531011793 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 405531011794 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 405531011795 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 405531011796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531011797 FeS/SAM binding site; other site 405531011798 HemN C-terminal domain; Region: HemN_C; pfam06969 405531011799 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531011800 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405531011801 GTP-binding protein LepA; Provisional; Region: PRK05433 405531011802 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 405531011803 G1 box; other site 405531011804 putative GEF interaction site [polypeptide binding]; other site 405531011805 GTP/Mg2+ binding site [chemical binding]; other site 405531011806 Switch I region; other site 405531011807 G2 box; other site 405531011808 G3 box; other site 405531011809 Switch II region; other site 405531011810 G4 box; other site 405531011811 G5 box; other site 405531011812 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 405531011813 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 405531011814 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 405531011815 Protein of unknown function (DUF3679); Region: DUF3679; pfam12438 405531011816 germination protease; Provisional; Region: PRK02858 405531011817 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 405531011818 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 405531011819 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405531011820 YqzM-like protein; Region: YqzM; pfam14141 405531011821 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 405531011822 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 405531011823 Competence protein; Region: Competence; pfam03772 405531011824 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531011825 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 405531011826 catalytic motif [active] 405531011827 Zn binding site [ion binding]; other site 405531011828 SLBB domain; Region: SLBB; pfam10531 405531011829 comEA protein; Region: comE; TIGR01259 405531011830 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 405531011831 late competence protein ComER; Validated; Region: PRK07680 405531011832 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405531011833 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 405531011834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531011835 S-adenosylmethionine binding site [chemical binding]; other site 405531011836 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 405531011837 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 405531011838 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531011839 Zn2+ binding site [ion binding]; other site 405531011840 Mg2+ binding site [ion binding]; other site 405531011841 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 405531011842 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 405531011843 active site 405531011844 (T/H)XGH motif; other site 405531011845 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 405531011846 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 405531011847 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405531011848 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405531011849 shikimate binding site; other site 405531011850 NAD(P) binding site [chemical binding]; other site 405531011851 GTPase YqeH; Provisional; Region: PRK13796 405531011852 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 405531011853 GTP/Mg2+ binding site [chemical binding]; other site 405531011854 G4 box; other site 405531011855 G5 box; other site 405531011856 G1 box; other site 405531011857 Switch I region; other site 405531011858 G2 box; other site 405531011859 G3 box; other site 405531011860 Switch II region; other site 405531011861 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 405531011862 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531011863 active site 405531011864 motif I; other site 405531011865 motif II; other site 405531011866 Sporulation inhibitor A; Region: Sda; pfam08970 405531011867 phosphatidylserine decarboxylase; Provisional; Region: PRK03140 405531011868 sporulation sigma factor SigK; Reviewed; Region: PRK05803 405531011869 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531011870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531011871 DNA binding residues [nucleotide binding] 405531011872 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 405531011873 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 405531011874 dimer interface [polypeptide binding]; other site 405531011875 FMN binding site [chemical binding]; other site 405531011876 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405531011877 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405531011878 synthetase active site [active] 405531011879 NTP binding site [chemical binding]; other site 405531011880 metal binding site [ion binding]; metal-binding site 405531011881 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405531011882 dimer interface [polypeptide binding]; other site 405531011883 Alkaline phosphatase homologues; Region: alkPPc; smart00098 405531011884 active site 405531011885 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405531011886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531011887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531011888 Coenzyme A binding pocket [chemical binding]; other site 405531011889 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531011890 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531011891 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 405531011892 catalytic site [active] 405531011893 DoxX; Region: DoxX; cl17842 405531011894 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405531011895 catalytic core [active] 405531011896 translocation protein TolB; Provisional; Region: tolB; PRK04792 405531011897 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 405531011898 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 405531011899 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405531011900 putative active site [active] 405531011901 catalytic triad [active] 405531011902 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 405531011903 putative integrin binding motif; other site 405531011904 PA/protease domain interface [polypeptide binding]; other site 405531011905 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 405531011906 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 405531011907 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 405531011908 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 405531011909 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 405531011910 cofactor binding site; other site 405531011911 metal binding site [ion binding]; metal-binding site 405531011912 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 405531011913 aromatic arch; other site 405531011914 DCoH dimer interaction site [polypeptide binding]; other site 405531011915 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 405531011916 DCoH tetramer interaction site [polypeptide binding]; other site 405531011917 substrate binding site [chemical binding]; other site 405531011918 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 405531011919 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 405531011920 putative metal binding site [ion binding]; other site 405531011921 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 405531011922 active site 405531011923 metal binding site [ion binding]; metal-binding site 405531011924 Predicted membrane protein [Function unknown]; Region: COG2259 405531011925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531011926 non-specific DNA binding site [nucleotide binding]; other site 405531011927 salt bridge; other site 405531011928 sequence-specific DNA binding site [nucleotide binding]; other site 405531011929 Cupin domain; Region: Cupin_2; pfam07883 405531011930 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405531011931 active site 2 [active] 405531011932 active site 1 [active] 405531011933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531011934 Coenzyme A binding pocket [chemical binding]; other site 405531011935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531011936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405531011937 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405531011938 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 405531011939 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405531011940 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405531011941 Walker A/P-loop; other site 405531011942 ATP binding site [chemical binding]; other site 405531011943 Q-loop/lid; other site 405531011944 ABC transporter signature motif; other site 405531011945 Walker B; other site 405531011946 D-loop; other site 405531011947 H-loop/switch region; other site 405531011948 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531011949 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531011950 ABC-ATPase subunit interface; other site 405531011951 dimer interface [polypeptide binding]; other site 405531011952 putative PBP binding regions; other site 405531011953 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405531011954 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405531011955 intersubunit interface [polypeptide binding]; other site 405531011956 YrhC-like protein; Region: YrhC; pfam14143 405531011957 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 405531011958 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 405531011959 putative catalytic cysteine [active] 405531011960 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 405531011961 putative active site [active] 405531011962 metal binding site [ion binding]; metal-binding site 405531011963 cystathionine beta-lyase; Provisional; Region: PRK07671 405531011964 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405531011965 homodimer interface [polypeptide binding]; other site 405531011966 substrate-cofactor binding pocket; other site 405531011967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011968 catalytic residue [active] 405531011969 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405531011970 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405531011971 dimer interface [polypeptide binding]; other site 405531011972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531011973 catalytic residue [active] 405531011974 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 405531011975 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405531011976 Methyltransferase domain; Region: Methyltransf_23; pfam13489 405531011977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531011978 S-adenosylmethionine binding site [chemical binding]; other site 405531011979 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 405531011980 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 405531011981 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 405531011982 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405531011983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531011984 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 405531011985 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405531011986 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405531011987 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405531011988 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405531011989 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 405531011990 ATP-binding site [chemical binding]; other site 405531011991 Sugar specificity; other site 405531011992 Pyrimidine base specificity; other site 405531011993 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405531011994 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405531011995 Peptidase family U32; Region: Peptidase_U32; pfam01136 405531011996 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405531011997 Protein of unknown function (DUF556); Region: DUF556; cl00822 405531011998 Peptidase family U32; Region: Peptidase_U32; pfam01136 405531011999 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405531012000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531012001 S-adenosylmethionine binding site [chemical binding]; other site 405531012002 YceG-like family; Region: YceG; pfam02618 405531012003 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 405531012004 dimerization interface [polypeptide binding]; other site 405531012005 hypothetical protein; Provisional; Region: PRK13678 405531012006 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 405531012007 hypothetical protein; Provisional; Region: PRK05473 405531012008 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 405531012009 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 405531012010 motif 1; other site 405531012011 active site 405531012012 motif 2; other site 405531012013 motif 3; other site 405531012014 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405531012015 DHHA1 domain; Region: DHHA1; pfam02272 405531012016 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405531012017 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405531012018 Protein of unknown function (DUF3918); Region: DUF3918; pfam13056 405531012019 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 405531012020 AAA domain; Region: AAA_30; pfam13604 405531012021 Family description; Region: UvrD_C_2; pfam13538 405531012022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531012023 TPR motif; other site 405531012024 TPR repeat; Region: TPR_11; pfam13414 405531012025 binding surface 405531012026 TPR repeat; Region: TPR_11; pfam13414 405531012027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531012028 binding surface 405531012029 TPR motif; other site 405531012030 TPR repeat; Region: TPR_11; pfam13414 405531012031 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 405531012032 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 405531012033 Ligand Binding Site [chemical binding]; other site 405531012034 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405531012035 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405531012036 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531012037 catalytic residue [active] 405531012038 Predicted transcriptional regulator [Transcription]; Region: COG1959 405531012039 Transcriptional regulator; Region: Rrf2; pfam02082 405531012040 recombination factor protein RarA; Reviewed; Region: PRK13342 405531012041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531012042 Walker A motif; other site 405531012043 ATP binding site [chemical binding]; other site 405531012044 Walker B motif; other site 405531012045 arginine finger; other site 405531012046 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405531012047 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405531012048 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405531012049 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 405531012050 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 405531012051 putative ATP binding site [chemical binding]; other site 405531012052 putative substrate interface [chemical binding]; other site 405531012053 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 405531012054 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 405531012055 dimer interface [polypeptide binding]; other site 405531012056 anticodon binding site; other site 405531012057 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405531012058 homodimer interface [polypeptide binding]; other site 405531012059 motif 1; other site 405531012060 active site 405531012061 motif 2; other site 405531012062 GAD domain; Region: GAD; pfam02938 405531012063 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405531012064 motif 3; other site 405531012065 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 405531012066 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405531012067 dimer interface [polypeptide binding]; other site 405531012068 motif 1; other site 405531012069 active site 405531012070 motif 2; other site 405531012071 motif 3; other site 405531012072 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405531012073 anticodon binding site; other site 405531012074 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 405531012075 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 405531012076 putative active site [active] 405531012077 dimerization interface [polypeptide binding]; other site 405531012078 putative tRNAtyr binding site [nucleotide binding]; other site 405531012079 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 405531012080 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531012081 Zn2+ binding site [ion binding]; other site 405531012082 Mg2+ binding site [ion binding]; other site 405531012083 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405531012084 synthetase active site [active] 405531012085 NTP binding site [chemical binding]; other site 405531012086 metal binding site [ion binding]; metal-binding site 405531012087 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405531012088 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405531012089 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531012090 active site 405531012091 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 405531012092 DHH family; Region: DHH; pfam01368 405531012093 DHHA1 domain; Region: DHHA1; pfam02272 405531012094 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 405531012095 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405531012096 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 405531012097 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 405531012098 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405531012099 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 405531012100 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405531012101 Protein export membrane protein; Region: SecD_SecF; pfam02355 405531012102 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 405531012103 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405531012104 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405531012105 Predicted membrane protein [Function unknown]; Region: COG2323 405531012106 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 405531012107 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 405531012108 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 405531012109 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 405531012110 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 405531012111 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 405531012112 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 405531012113 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 405531012114 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531012115 Walker A motif; other site 405531012116 ATP binding site [chemical binding]; other site 405531012117 Walker B motif; other site 405531012118 arginine finger; other site 405531012119 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 405531012120 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 405531012121 RuvA N terminal domain; Region: RuvA_N; pfam01330 405531012122 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 405531012123 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405531012124 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 405531012125 putative ligand binding residues [chemical binding]; other site 405531012126 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 405531012127 BofC C-terminal domain; Region: BofC_C; pfam08955 405531012128 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405531012129 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531012130 quinolinate synthetase; Provisional; Region: PRK09375 405531012131 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 405531012132 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 405531012133 dimerization interface [polypeptide binding]; other site 405531012134 active site 405531012135 L-aspartate oxidase; Provisional; Region: PRK08071 405531012136 L-aspartate oxidase; Provisional; Region: PRK06175 405531012137 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405531012138 cysteine desulfurase; Provisional; Region: PRK02948 405531012139 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405531012140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531012141 catalytic residue [active] 405531012142 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 405531012143 HTH domain; Region: HTH_11; pfam08279 405531012144 3H domain; Region: 3H; pfam02829 405531012145 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 405531012146 MOSC domain; Region: MOSC; pfam03473 405531012147 3-alpha domain; Region: 3-alpha; pfam03475 405531012148 prephenate dehydratase; Provisional; Region: PRK11898 405531012149 Prephenate dehydratase; Region: PDT; pfam00800 405531012150 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 405531012151 putative L-Phe binding site [chemical binding]; other site 405531012152 FtsX-like permease family; Region: FtsX; pfam02687 405531012153 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531012154 FtsX-like permease family; Region: FtsX; pfam02687 405531012155 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531012156 FtsX-like permease family; Region: FtsX; pfam02687 405531012157 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531012158 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531012159 Walker A/P-loop; other site 405531012160 ATP binding site [chemical binding]; other site 405531012161 Q-loop/lid; other site 405531012162 ABC transporter signature motif; other site 405531012163 Walker B; other site 405531012164 D-loop; other site 405531012165 H-loop/switch region; other site 405531012166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531012167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 405531012168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531012169 ATP binding site [chemical binding]; other site 405531012170 Mg2+ binding site [ion binding]; other site 405531012171 G-X-G motif; other site 405531012172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531012173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531012174 active site 405531012175 phosphorylation site [posttranslational modification] 405531012176 intermolecular recognition site; other site 405531012177 dimerization interface [polypeptide binding]; other site 405531012178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531012179 DNA binding site [nucleotide binding] 405531012180 GTPase CgtA; Reviewed; Region: obgE; PRK12297 405531012181 GTP1/OBG; Region: GTP1_OBG; pfam01018 405531012182 Obg GTPase; Region: Obg; cd01898 405531012183 G1 box; other site 405531012184 GTP/Mg2+ binding site [chemical binding]; other site 405531012185 Switch I region; other site 405531012186 G2 box; other site 405531012187 G3 box; other site 405531012188 Switch II region; other site 405531012189 G4 box; other site 405531012190 G5 box; other site 405531012191 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 405531012192 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 405531012193 hypothetical protein; Provisional; Region: PRK14553 405531012194 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 405531012195 Ribosomal protein L21 leader 405531012196 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 405531012197 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 405531012198 homodimer interface [polypeptide binding]; other site 405531012199 oligonucleotide binding site [chemical binding]; other site 405531012200 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 405531012201 Peptidase family M50; Region: Peptidase_M50; pfam02163 405531012202 active site 405531012203 putative substrate binding region [chemical binding]; other site 405531012204 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531012205 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531012206 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 405531012207 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 405531012208 Switch I; other site 405531012209 Switch II; other site 405531012210 septum formation inhibitor; Reviewed; Region: minC; PRK00513 405531012211 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 405531012212 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 405531012213 rod shape-determining protein MreC; Provisional; Region: PRK13922 405531012214 rod shape-determining protein MreC; Region: MreC; pfam04085 405531012215 rod shape-determining protein MreB; Provisional; Region: PRK13927 405531012216 MreB and similar proteins; Region: MreB_like; cd10225 405531012217 nucleotide binding site [chemical binding]; other site 405531012218 Mg binding site [ion binding]; other site 405531012219 putative protofilament interaction site [polypeptide binding]; other site 405531012220 RodZ interaction site [polypeptide binding]; other site 405531012221 hypothetical protein; Reviewed; Region: PRK00024 405531012222 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405531012223 MPN+ (JAMM) motif; other site 405531012224 Zinc-binding site [ion binding]; other site 405531012225 Maf-like protein; Region: Maf; pfam02545 405531012226 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 405531012227 active site 405531012228 dimer interface [polypeptide binding]; other site 405531012229 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 405531012230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405531012231 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405531012232 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 405531012233 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405531012234 active site 405531012235 HIGH motif; other site 405531012236 nucleotide binding site [chemical binding]; other site 405531012237 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405531012238 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405531012239 active site 405531012240 KMSKS motif; other site 405531012241 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 405531012242 tRNA binding surface [nucleotide binding]; other site 405531012243 anticodon binding site; other site 405531012244 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 405531012245 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 405531012246 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 405531012247 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 405531012248 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405531012249 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 405531012250 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405531012251 inhibitor-cofactor binding pocket; inhibition site 405531012252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531012253 catalytic residue [active] 405531012254 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 405531012255 dimer interface [polypeptide binding]; other site 405531012256 active site 405531012257 Schiff base residues; other site 405531012258 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 405531012259 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405531012260 active site 405531012261 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 405531012262 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 405531012263 domain interfaces; other site 405531012264 active site 405531012265 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 405531012266 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 405531012267 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 405531012268 tRNA; other site 405531012269 putative tRNA binding site [nucleotide binding]; other site 405531012270 putative NADP binding site [chemical binding]; other site 405531012271 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 405531012272 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405531012273 MarR family; Region: MarR; pfam01047 405531012274 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 405531012275 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 405531012276 G1 box; other site 405531012277 GTP/Mg2+ binding site [chemical binding]; other site 405531012278 Switch I region; other site 405531012279 G2 box; other site 405531012280 G3 box; other site 405531012281 Switch II region; other site 405531012282 G4 box; other site 405531012283 G5 box; other site 405531012284 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 405531012285 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405531012286 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405531012287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531012288 Walker A motif; other site 405531012289 ATP binding site [chemical binding]; other site 405531012290 Walker B motif; other site 405531012291 arginine finger; other site 405531012292 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405531012293 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 405531012294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531012295 Walker A motif; other site 405531012296 ATP binding site [chemical binding]; other site 405531012297 Walker B motif; other site 405531012298 arginine finger; other site 405531012299 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405531012300 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 405531012301 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 405531012302 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531012303 Walker A motif; other site 405531012304 ATP binding site [chemical binding]; other site 405531012305 Walker B motif; other site 405531012306 arginine finger; other site 405531012307 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405531012308 trigger factor; Provisional; Region: tig; PRK01490 405531012309 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405531012310 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 405531012311 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 405531012312 pentamer interface [polypeptide binding]; other site 405531012313 dodecaamer interface [polypeptide binding]; other site 405531012314 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 405531012315 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 405531012316 active site 405531012317 metal binding site [ion binding]; metal-binding site 405531012318 homotetramer interface [polypeptide binding]; other site 405531012319 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405531012320 active site 405531012321 dimerization interface [polypeptide binding]; other site 405531012322 ribonuclease PH; Reviewed; Region: rph; PRK00173 405531012323 Ribonuclease PH; Region: RNase_PH_bact; cd11362 405531012324 hexamer interface [polypeptide binding]; other site 405531012325 active site 405531012326 Sporulation and spore germination; Region: Germane; pfam10646 405531012327 Spore germination protein [General function prediction only]; Region: COG5401 405531012328 Sporulation and spore germination; Region: Germane; pfam10646 405531012329 glutamate racemase; Provisional; Region: PRK00865 405531012330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531012331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531012332 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405531012333 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 405531012334 potential catalytic triad [active] 405531012335 conserved cys residue [active] 405531012336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531012337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531012338 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 405531012339 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405531012340 potential catalytic triad [active] 405531012341 conserved cys residue [active] 405531012342 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531012343 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531012344 DNA binding residues [nucleotide binding] 405531012345 dimerization interface [polypeptide binding]; other site 405531012346 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405531012347 putative deaminase; Validated; Region: PRK06846 405531012348 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405531012349 active site 405531012350 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 405531012351 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531012352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531012353 non-specific DNA binding site [nucleotide binding]; other site 405531012354 salt bridge; other site 405531012355 sequence-specific DNA binding site [nucleotide binding]; other site 405531012356 Cupin domain; Region: Cupin_2; pfam07883 405531012357 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 405531012358 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 405531012359 amphipathic channel; other site 405531012360 Asn-Pro-Ala signature motifs; other site 405531012361 Predicted transcriptional regulator [Transcription]; Region: COG1959 405531012362 Transcriptional regulator; Region: Rrf2; pfam02082 405531012363 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 405531012364 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 405531012365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531012366 Walker A/P-loop; other site 405531012367 ATP binding site [chemical binding]; other site 405531012368 Q-loop/lid; other site 405531012369 ABC transporter signature motif; other site 405531012370 Walker B; other site 405531012371 D-loop; other site 405531012372 H-loop/switch region; other site 405531012373 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 405531012374 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531012375 active site 405531012376 motif I; other site 405531012377 motif II; other site 405531012378 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 405531012379 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 405531012380 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405531012381 ligand binding site [chemical binding]; other site 405531012382 flagellar motor protein MotA; Validated; Region: PRK08124 405531012383 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 405531012384 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405531012385 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405531012386 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405531012387 active site 405531012388 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 405531012389 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 405531012390 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405531012391 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 405531012392 L-aspartate oxidase; Provisional; Region: PRK06175 405531012393 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405531012394 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 405531012395 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 405531012396 putative Iron-sulfur protein interface [polypeptide binding]; other site 405531012397 proximal heme binding site [chemical binding]; other site 405531012398 distal heme binding site [chemical binding]; other site 405531012399 putative dimer interface [polypeptide binding]; other site 405531012400 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 405531012401 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 405531012402 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405531012403 GIY-YIG motif/motif A; other site 405531012404 active site 405531012405 catalytic site [active] 405531012406 putative DNA binding site [nucleotide binding]; other site 405531012407 metal binding site [ion binding]; metal-binding site 405531012408 UvrB/uvrC motif; Region: UVR; pfam02151 405531012409 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 405531012410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531012411 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 405531012412 catalytic residues [active] 405531012413 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 405531012414 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 405531012415 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405531012416 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405531012417 Ligand binding site [chemical binding]; other site 405531012418 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405531012419 enoyl-CoA hydratase; Provisional; Region: PRK07658 405531012420 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405531012421 substrate binding site [chemical binding]; other site 405531012422 oxyanion hole (OAH) forming residues; other site 405531012423 trimer interface [polypeptide binding]; other site 405531012424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 405531012425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531012426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531012427 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 405531012428 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 405531012429 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405531012430 acyl-activating enzyme (AAE) consensus motif; other site 405531012431 putative AMP binding site [chemical binding]; other site 405531012432 putative active site [active] 405531012433 putative CoA binding site [chemical binding]; other site 405531012434 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 405531012435 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405531012436 siderophore binding site; other site 405531012437 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531012438 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531012439 ABC-ATPase subunit interface; other site 405531012440 dimer interface [polypeptide binding]; other site 405531012441 putative PBP binding regions; other site 405531012442 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531012443 ABC-ATPase subunit interface; other site 405531012444 dimer interface [polypeptide binding]; other site 405531012445 putative PBP binding regions; other site 405531012446 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 405531012447 DinB family; Region: DinB; cl17821 405531012448 DinB superfamily; Region: DinB_2; pfam12867 405531012449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 405531012450 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 405531012451 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531012452 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405531012453 Walker A/P-loop; other site 405531012454 ATP binding site [chemical binding]; other site 405531012455 Q-loop/lid; other site 405531012456 ABC transporter signature motif; other site 405531012457 Walker B; other site 405531012458 D-loop; other site 405531012459 H-loop/switch region; other site 405531012460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531012461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531012462 dimer interface [polypeptide binding]; other site 405531012463 phosphorylation site [posttranslational modification] 405531012464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531012465 ATP binding site [chemical binding]; other site 405531012466 Mg2+ binding site [ion binding]; other site 405531012467 G-X-G motif; other site 405531012468 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531012469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531012470 active site 405531012471 phosphorylation site [posttranslational modification] 405531012472 intermolecular recognition site; other site 405531012473 dimerization interface [polypeptide binding]; other site 405531012474 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531012475 DNA binding site [nucleotide binding] 405531012476 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 405531012477 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 405531012478 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 405531012479 putative RNA binding site [nucleotide binding]; other site 405531012480 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 405531012481 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 405531012482 active site 405531012483 catalytic site [active] 405531012484 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405531012485 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405531012486 Walker A/P-loop; other site 405531012487 ATP binding site [chemical binding]; other site 405531012488 Q-loop/lid; other site 405531012489 ABC transporter signature motif; other site 405531012490 Walker B; other site 405531012491 D-loop; other site 405531012492 H-loop/switch region; other site 405531012493 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531012494 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531012495 ABC-ATPase subunit interface; other site 405531012496 dimer interface [polypeptide binding]; other site 405531012497 putative PBP binding regions; other site 405531012498 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 405531012499 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405531012500 intersubunit interface [polypeptide binding]; other site 405531012501 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012502 heme-binding site [chemical binding]; other site 405531012503 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012504 heme-binding site [chemical binding]; other site 405531012505 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012506 heme-binding site [chemical binding]; other site 405531012507 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012508 heme-binding site [chemical binding]; other site 405531012509 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012510 heme-binding site [chemical binding]; other site 405531012511 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012512 heme-binding site [chemical binding]; other site 405531012513 heme uptake protein IsdC; Region: IsdC; TIGR03656 405531012514 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 405531012515 heme-binding site [chemical binding]; other site 405531012516 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 405531012517 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 405531012518 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405531012519 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531012520 RNA binding surface [nucleotide binding]; other site 405531012521 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405531012522 probable active site [active] 405531012523 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 405531012524 MutS domain III; Region: MutS_III; pfam05192 405531012525 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 405531012526 Walker A/P-loop; other site 405531012527 ATP binding site [chemical binding]; other site 405531012528 Q-loop/lid; other site 405531012529 ABC transporter signature motif; other site 405531012530 Walker B; other site 405531012531 D-loop; other site 405531012532 H-loop/switch region; other site 405531012533 Smr domain; Region: Smr; pfam01713 405531012534 hypothetical protein; Provisional; Region: PRK08609 405531012535 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 405531012536 active site 405531012537 primer binding site [nucleotide binding]; other site 405531012538 NTP binding site [chemical binding]; other site 405531012539 metal binding triad [ion binding]; metal-binding site 405531012540 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 405531012541 active site 405531012542 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 405531012543 Colicin V production protein; Region: Colicin_V; pfam02674 405531012544 cell division protein ZapA; Provisional; Region: PRK14126 405531012545 ribonuclease HIII; Provisional; Region: PRK00996 405531012546 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 405531012547 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 405531012548 RNA/DNA hybrid binding site [nucleotide binding]; other site 405531012549 active site 405531012550 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 405531012551 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 405531012552 putative dimer interface [polypeptide binding]; other site 405531012553 putative anticodon binding site; other site 405531012554 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405531012555 homodimer interface [polypeptide binding]; other site 405531012556 motif 1; other site 405531012557 motif 2; other site 405531012558 active site 405531012559 motif 3; other site 405531012560 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 405531012561 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405531012562 putative tRNA-binding site [nucleotide binding]; other site 405531012563 B3/4 domain; Region: B3_4; pfam03483 405531012564 tRNA synthetase B5 domain; Region: B5; smart00874 405531012565 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 405531012566 dimer interface [polypeptide binding]; other site 405531012567 motif 1; other site 405531012568 motif 3; other site 405531012569 motif 2; other site 405531012570 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 405531012571 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 405531012572 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 405531012573 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 405531012574 dimer interface [polypeptide binding]; other site 405531012575 motif 1; other site 405531012576 active site 405531012577 motif 2; other site 405531012578 motif 3; other site 405531012579 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 405531012580 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 405531012581 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405531012582 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 405531012583 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531012584 Zn2+ binding site [ion binding]; other site 405531012585 Mg2+ binding site [ion binding]; other site 405531012586 CAAX protease self-immunity; Region: Abi; pfam02517 405531012587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531012588 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405531012589 putative substrate translocation pore; other site 405531012590 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531012591 HlyD family secretion protein; Region: HlyD_3; pfam13437 405531012592 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 405531012593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531012594 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 405531012595 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405531012596 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405531012597 oligomer interface [polypeptide binding]; other site 405531012598 active site 405531012599 metal binding site [ion binding]; metal-binding site 405531012600 dUTPase; Region: dUTPase_2; pfam08761 405531012601 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 405531012602 active site 405531012603 homodimer interface [polypeptide binding]; other site 405531012604 metal binding site [ion binding]; metal-binding site 405531012605 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 405531012606 23S rRNA binding site [nucleotide binding]; other site 405531012607 L21 binding site [polypeptide binding]; other site 405531012608 L13 binding site [polypeptide binding]; other site 405531012609 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 405531012610 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 405531012611 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 405531012612 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 405531012613 Ribosomal protein L20 leader 405531012614 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 405531012615 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405531012616 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405531012617 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405531012618 active site 405531012619 dimer interface [polypeptide binding]; other site 405531012620 motif 1; other site 405531012621 motif 2; other site 405531012622 motif 3; other site 405531012623 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405531012624 anticodon binding site; other site 405531012625 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 405531012626 primosomal protein DnaI; Reviewed; Region: PRK08939 405531012627 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 405531012628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531012629 Walker A motif; other site 405531012630 ATP binding site [chemical binding]; other site 405531012631 Walker B motif; other site 405531012632 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 405531012633 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 405531012634 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 405531012635 ATP cone domain; Region: ATP-cone; pfam03477 405531012636 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 405531012637 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 405531012638 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 405531012639 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405531012640 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 405531012641 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 405531012642 CoA-binding site [chemical binding]; other site 405531012643 ATP-binding [chemical binding]; other site 405531012644 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 405531012645 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 405531012646 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 405531012647 DNA binding site [nucleotide binding] 405531012648 catalytic residue [active] 405531012649 H2TH interface [polypeptide binding]; other site 405531012650 putative catalytic residues [active] 405531012651 turnover-facilitating residue; other site 405531012652 intercalation triad [nucleotide binding]; other site 405531012653 8OG recognition residue [nucleotide binding]; other site 405531012654 putative reading head residues; other site 405531012655 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405531012656 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405531012657 DNA polymerase I; Provisional; Region: PRK05755 405531012658 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405531012659 active site 405531012660 metal binding site 1 [ion binding]; metal-binding site 405531012661 putative 5' ssDNA interaction site; other site 405531012662 metal binding site 3; metal-binding site 405531012663 metal binding site 2 [ion binding]; metal-binding site 405531012664 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405531012665 putative DNA binding site [nucleotide binding]; other site 405531012666 putative metal binding site [ion binding]; other site 405531012667 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 405531012668 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 405531012669 active site 405531012670 DNA binding site [nucleotide binding] 405531012671 catalytic site [active] 405531012672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531012673 dimerization interface [polypeptide binding]; other site 405531012674 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 405531012675 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531012676 putative active site [active] 405531012677 heme pocket [chemical binding]; other site 405531012678 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531012679 dimer interface [polypeptide binding]; other site 405531012680 phosphorylation site [posttranslational modification] 405531012681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531012682 ATP binding site [chemical binding]; other site 405531012683 Mg2+ binding site [ion binding]; other site 405531012684 G-X-G motif; other site 405531012685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531012686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531012687 active site 405531012688 phosphorylation site [posttranslational modification] 405531012689 intermolecular recognition site; other site 405531012690 dimerization interface [polypeptide binding]; other site 405531012691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531012692 DNA binding site [nucleotide binding] 405531012693 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 405531012694 active site 2 [active] 405531012695 active site 1 [active] 405531012696 malate dehydrogenase; Reviewed; Region: PRK06223 405531012697 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 405531012698 NAD(P) binding site [chemical binding]; other site 405531012699 dimer interface [polypeptide binding]; other site 405531012700 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531012701 substrate binding site [chemical binding]; other site 405531012702 isocitrate dehydrogenase; Reviewed; Region: PRK07006 405531012703 isocitrate dehydrogenase; Validated; Region: PRK07362 405531012704 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 405531012705 dimer interface [polypeptide binding]; other site 405531012706 Citrate synthase; Region: Citrate_synt; pfam00285 405531012707 active site 405531012708 citrylCoA binding site [chemical binding]; other site 405531012709 oxalacetate/citrate binding site [chemical binding]; other site 405531012710 coenzyme A binding site [chemical binding]; other site 405531012711 catalytic triad [active] 405531012712 Protein of unknown function (DUF441); Region: DUF441; pfam04284 405531012713 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405531012714 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 405531012715 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 405531012716 pyruvate kinase; Provisional; Region: PRK06354 405531012717 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 405531012718 domain interfaces; other site 405531012719 active site 405531012720 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 405531012721 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 405531012722 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 405531012723 active site 405531012724 ADP/pyrophosphate binding site [chemical binding]; other site 405531012725 dimerization interface [polypeptide binding]; other site 405531012726 allosteric effector site; other site 405531012727 fructose-1,6-bisphosphate binding site; other site 405531012728 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 405531012729 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 405531012730 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 405531012731 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 405531012732 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 405531012733 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405531012734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531012735 DNA-binding site [nucleotide binding]; DNA binding site 405531012736 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 405531012737 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405531012738 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405531012739 putative NAD(P) binding site [chemical binding]; other site 405531012740 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 405531012741 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405531012742 active site 405531012743 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 405531012744 generic binding surface II; other site 405531012745 generic binding surface I; other site 405531012746 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 405531012747 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 405531012748 DHH family; Region: DHH; pfam01368 405531012749 DHHA1 domain; Region: DHHA1; pfam02272 405531012750 YtpI-like protein; Region: YtpI; pfam14007 405531012751 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405531012752 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 405531012753 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531012754 DNA-binding site [nucleotide binding]; DNA binding site 405531012755 DRTGG domain; Region: DRTGG; pfam07085 405531012756 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 405531012757 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 405531012758 active site 2 [active] 405531012759 active site 1 [active] 405531012760 metal-dependent hydrolase; Provisional; Region: PRK00685 405531012761 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405531012762 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 405531012763 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405531012764 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405531012765 active site 405531012766 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 405531012767 Protein of unknown function (DUF3221); Region: DUF3221; pfam11518 405531012768 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 405531012769 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 405531012770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531012771 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531012772 Coenzyme A binding pocket [chemical binding]; other site 405531012773 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 405531012774 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 405531012775 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 405531012776 hexamer interface [polypeptide binding]; other site 405531012777 ligand binding site [chemical binding]; other site 405531012778 putative active site [active] 405531012779 NAD(P) binding site [chemical binding]; other site 405531012780 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 405531012781 classical (c) SDRs; Region: SDR_c; cd05233 405531012782 NAD(P) binding site [chemical binding]; other site 405531012783 active site 405531012784 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405531012785 Ligand Binding Site [chemical binding]; other site 405531012786 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 405531012787 argininosuccinate lyase; Provisional; Region: PRK00855 405531012788 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405531012789 active sites [active] 405531012790 tetramer interface [polypeptide binding]; other site 405531012791 argininosuccinate synthase; Provisional; Region: PRK13820 405531012792 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 405531012793 ANP binding site [chemical binding]; other site 405531012794 Substrate Binding Site II [chemical binding]; other site 405531012795 Substrate Binding Site I [chemical binding]; other site 405531012796 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531012797 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531012798 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531012799 EcsC protein family; Region: EcsC; pfam12787 405531012800 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 405531012801 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 405531012802 nudix motif; other site 405531012803 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405531012804 propionate/acetate kinase; Provisional; Region: PRK12379 405531012805 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 405531012806 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531012807 S-adenosylmethionine binding site [chemical binding]; other site 405531012808 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 405531012809 dimer interface [polypeptide binding]; other site 405531012810 catalytic triad [active] 405531012811 peroxidatic and resolving cysteines [active] 405531012812 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 405531012813 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 405531012814 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03501 405531012815 ATP-NAD kinase; Region: NAD_kinase; pfam01513 405531012816 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 405531012817 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 405531012818 active site 405531012819 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531012820 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405531012821 dimer interface [polypeptide binding]; other site 405531012822 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 405531012823 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 405531012824 active site 405531012825 acyl-activating enzyme (AAE) consensus motif; other site 405531012826 putative CoA binding site [chemical binding]; other site 405531012827 AMP binding site [chemical binding]; other site 405531012828 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531012829 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 405531012830 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 405531012831 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 405531012832 Ligand Binding Site [chemical binding]; other site 405531012833 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 405531012834 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405531012835 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531012836 catalytic residue [active] 405531012837 septation ring formation regulator EzrA; Provisional; Region: PRK04778 405531012838 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531012839 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531012840 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405531012841 dimerization interface [polypeptide binding]; other site 405531012842 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531012843 EamA-like transporter family; Region: EamA; pfam00892 405531012844 EamA-like transporter family; Region: EamA; pfam00892 405531012845 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531012846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531012847 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 405531012848 GAF domain; Region: GAF_2; pfam13185 405531012849 methionine gamma-lyase; Provisional; Region: PRK06767 405531012850 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405531012851 homodimer interface [polypeptide binding]; other site 405531012852 substrate-cofactor binding pocket; other site 405531012853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531012854 catalytic residue [active] 405531012855 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 405531012856 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 405531012857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531012858 RNA binding surface [nucleotide binding]; other site 405531012859 LXG domain of WXG superfamily; Region: LXG; pfam04740 405531012860 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; pfam12639 405531012861 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 405531012862 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 405531012863 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 405531012864 active site 405531012865 HIGH motif; other site 405531012866 dimer interface [polypeptide binding]; other site 405531012867 KMSKS motif; other site 405531012868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531012869 RNA binding surface [nucleotide binding]; other site 405531012870 maltose O-acetyltransferase; Provisional; Region: PRK10092 405531012871 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405531012872 active site 405531012873 substrate binding site [chemical binding]; other site 405531012874 trimer interface [polypeptide binding]; other site 405531012875 CoA binding site [chemical binding]; other site 405531012876 acetyl-CoA synthetase; Provisional; Region: PRK04319 405531012877 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 405531012878 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 405531012879 active site 405531012880 acyl-activating enzyme (AAE) consensus motif; other site 405531012881 putative CoA binding site [chemical binding]; other site 405531012882 AMP binding site [chemical binding]; other site 405531012883 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531012884 Coenzyme A binding pocket [chemical binding]; other site 405531012885 FOG: CBS domain [General function prediction only]; Region: COG0517 405531012886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 405531012887 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 405531012888 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 405531012889 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 405531012890 active site 405531012891 Zn binding site [ion binding]; other site 405531012892 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 405531012893 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531012894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531012895 active site 405531012896 phosphorylation site [posttranslational modification] 405531012897 intermolecular recognition site; other site 405531012898 dimerization interface [polypeptide binding]; other site 405531012899 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531012900 DNA binding site [nucleotide binding] 405531012901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531012902 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531012903 dimerization interface [polypeptide binding]; other site 405531012904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531012905 dimer interface [polypeptide binding]; other site 405531012906 phosphorylation site [posttranslational modification] 405531012907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531012908 ATP binding site [chemical binding]; other site 405531012909 Mg2+ binding site [ion binding]; other site 405531012910 G-X-G motif; other site 405531012911 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 405531012912 Ankyrin repeat; Region: Ank; pfam00023 405531012913 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405531012914 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405531012915 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 405531012916 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405531012917 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405531012918 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13955 405531012919 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 405531012920 Protein of unknown function (DUF3917); Region: DUF3917; pfam13055 405531012921 Protein of unknown function (DUF3949); Region: DUF3949; pfam13133 405531012922 Domain of unknown function (DUF4288); Region: DUF4288; pfam14119 405531012923 catabolite control protein A; Region: ccpA; TIGR01481 405531012924 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531012925 DNA binding site [nucleotide binding] 405531012926 domain linker motif; other site 405531012927 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 405531012928 dimerization interface [polypeptide binding]; other site 405531012929 effector binding site; other site 405531012930 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 405531012931 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 405531012932 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 405531012933 putative dimer interface [polypeptide binding]; other site 405531012934 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 405531012935 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 405531012936 putative dimer interface [polypeptide binding]; other site 405531012937 Protein of unknown function (DUF2847); Region: DUF2847; pfam11009 405531012938 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 405531012939 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 405531012940 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 405531012941 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 405531012942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405531012943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531012944 Coenzyme A binding pocket [chemical binding]; other site 405531012945 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531012946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531012947 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531012948 EamA-like transporter family; Region: EamA; pfam00892 405531012949 EamA-like transporter family; Region: EamA; pfam00892 405531012950 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 405531012951 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531012952 DNA binding residues [nucleotide binding] 405531012953 putative dimer interface [polypeptide binding]; other site 405531012954 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 405531012955 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405531012956 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405531012957 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405531012958 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 405531012959 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 405531012960 active site 405531012961 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 405531012962 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405531012963 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405531012964 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 405531012965 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405531012966 active site 405531012967 metal binding site [ion binding]; metal-binding site 405531012968 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405531012969 putative tRNA-binding site [nucleotide binding]; other site 405531012970 hypothetical protein; Provisional; Region: PRK13668 405531012971 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531012972 catalytic residues [active] 405531012973 NTPase; Reviewed; Region: PRK03114 405531012974 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 405531012975 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 405531012976 oligomer interface [polypeptide binding]; other site 405531012977 active site 405531012978 metal binding site [ion binding]; metal-binding site 405531012979 Predicted small secreted protein [Function unknown]; Region: COG5584 405531012980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531012981 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531012982 S-adenosylmethionine binding site [chemical binding]; other site 405531012983 YtzH-like protein; Region: YtzH; pfam14165 405531012984 Phosphotransferase enzyme family; Region: APH; pfam01636 405531012985 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405531012986 active site 405531012987 substrate binding site [chemical binding]; other site 405531012988 ATP binding site [chemical binding]; other site 405531012989 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405531012990 pullulanase, type I; Region: pulA_typeI; TIGR02104 405531012991 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 405531012992 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 405531012993 Ca binding site [ion binding]; other site 405531012994 active site 405531012995 catalytic site [active] 405531012996 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 405531012997 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405531012998 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405531012999 dipeptidase PepV; Reviewed; Region: PRK07318 405531013000 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 405531013001 active site 405531013002 metal binding site [ion binding]; metal-binding site 405531013003 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 405531013004 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 405531013005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531013006 RNA binding surface [nucleotide binding]; other site 405531013007 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 405531013008 active site 405531013009 uracil binding [chemical binding]; other site 405531013010 stage V sporulation protein B; Region: spore_V_B; TIGR02900 405531013011 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 405531013012 HI0933-like protein; Region: HI0933_like; pfam03486 405531013013 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531013014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531013015 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013016 putative substrate translocation pore; other site 405531013017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013018 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531013019 dimerization interface [polypeptide binding]; other site 405531013020 putative DNA binding site [nucleotide binding]; other site 405531013021 putative Zn2+ binding site [ion binding]; other site 405531013022 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 405531013023 putative hydrophobic ligand binding site [chemical binding]; other site 405531013024 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 405531013025 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 405531013026 Protein of unknown function (DUF2553); Region: DUF2553; pfam10830 405531013027 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 405531013028 glucose-1-dehydrogenase; Provisional; Region: PRK08936 405531013029 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 405531013030 NAD binding site [chemical binding]; other site 405531013031 homodimer interface [polypeptide binding]; other site 405531013032 active site 405531013033 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 405531013034 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 405531013035 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 405531013036 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 405531013037 MoaE interaction surface [polypeptide binding]; other site 405531013038 MoeB interaction surface [polypeptide binding]; other site 405531013039 thiocarboxylated glycine; other site 405531013040 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405531013041 MoaE homodimer interface [polypeptide binding]; other site 405531013042 MoaD interaction [polypeptide binding]; other site 405531013043 active site residues [active] 405531013044 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 405531013045 Walker A motif; other site 405531013046 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 405531013047 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405531013048 dimer interface [polypeptide binding]; other site 405531013049 putative functional site; other site 405531013050 putative MPT binding site; other site 405531013051 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 405531013052 trimer interface [polypeptide binding]; other site 405531013053 dimer interface [polypeptide binding]; other site 405531013054 putative active site [active] 405531013055 thiamine/molybdopterin biosynthesis MoeB-like protein; Provisional; Region: PRK12475 405531013056 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405531013057 ATP binding site [chemical binding]; other site 405531013058 substrate interface [chemical binding]; other site 405531013059 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 405531013060 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531013061 FeS/SAM binding site; other site 405531013062 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405531013063 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 405531013064 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405531013065 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405531013066 active site residue [active] 405531013067 homoserine O-acetyltransferase; Provisional; Region: PRK06765 405531013068 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405531013069 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 405531013070 Spore germination protein; Region: Spore_permease; pfam03845 405531013071 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 405531013072 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 405531013073 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 405531013074 putative nucleotide binding site [chemical binding]; other site 405531013075 putative metal binding site [ion binding]; other site 405531013076 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 405531013077 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405531013078 HIGH motif; other site 405531013079 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405531013080 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405531013081 active site 405531013082 KMSKS motif; other site 405531013083 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 405531013084 tRNA binding surface [nucleotide binding]; other site 405531013085 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013086 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531013087 putative substrate translocation pore; other site 405531013088 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405531013089 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405531013090 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405531013091 TrkA-C domain; Region: TrkA_C; pfam02080 405531013092 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 405531013093 Int/Topo IB signature motif; other site 405531013094 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531013095 FtsX-like permease family; Region: FtsX; pfam02687 405531013096 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531013097 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531013098 Walker A/P-loop; other site 405531013099 ATP binding site [chemical binding]; other site 405531013100 Q-loop/lid; other site 405531013101 ABC transporter signature motif; other site 405531013102 Walker B; other site 405531013103 D-loop; other site 405531013104 H-loop/switch region; other site 405531013105 Protein of unknown function (DUF418); Region: DUF418; cl12135 405531013106 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405531013107 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 405531013108 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 405531013109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531013110 FeS/SAM binding site; other site 405531013111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531013112 S-adenosylmethionine binding site [chemical binding]; other site 405531013113 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 405531013114 aspartate racemase; Region: asp_race; TIGR00035 405531013115 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 405531013116 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 405531013117 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 405531013118 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 405531013119 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531013120 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531013121 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405531013122 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 405531013123 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 405531013124 trimer interface [polypeptide binding]; other site 405531013125 putative metal binding site [ion binding]; other site 405531013126 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 405531013127 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405531013128 active site 405531013129 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405531013130 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 405531013131 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 405531013132 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 405531013133 GTP binding site; other site 405531013134 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 405531013135 MPT binding site; other site 405531013136 trimer interface [polypeptide binding]; other site 405531013137 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405531013138 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405531013139 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405531013140 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405531013141 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 405531013142 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 405531013143 active site 405531013144 substrate-binding site [chemical binding]; other site 405531013145 metal-binding site [ion binding] 405531013146 ATP binding site [chemical binding]; other site 405531013147 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405531013148 EamA-like transporter family; Region: EamA; pfam00892 405531013149 EamA-like transporter family; Region: EamA; pfam00892 405531013150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 405531013151 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405531013152 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 405531013153 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 405531013154 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 405531013155 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405531013156 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405531013157 WxL domain surface cell wall-binding; Region: WxL; pfam13731 405531013158 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531013159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013160 ATP binding site [chemical binding]; other site 405531013161 Mg2+ binding site [ion binding]; other site 405531013162 G-X-G motif; other site 405531013163 potential frameshift: common BLAST hit: gi|30022844|ref|NP_834475.1| sporulation kinase 405531013164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531013165 dimer interface [polypeptide binding]; other site 405531013166 phosphorylation site [posttranslational modification] 405531013167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013168 ATP binding site [chemical binding]; other site 405531013169 Mg2+ binding site [ion binding]; other site 405531013170 G-X-G motif; other site 405531013171 hydroperoxidase II; Provisional; Region: katE; PRK11249 405531013172 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 405531013173 heme binding pocket [chemical binding]; other site 405531013174 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 405531013175 domain interactions; other site 405531013176 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 405531013177 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405531013178 Sulfatase; Region: Sulfatase; pfam00884 405531013179 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405531013180 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 405531013181 Protein of unknown function (DUF3986); Region: DUF3986; pfam13143 405531013182 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 405531013183 NMT1-like family; Region: NMT1_2; pfam13379 405531013184 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 405531013185 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405531013186 Walker A/P-loop; other site 405531013187 ATP binding site [chemical binding]; other site 405531013188 Q-loop/lid; other site 405531013189 ABC transporter signature motif; other site 405531013190 Walker B; other site 405531013191 D-loop; other site 405531013192 H-loop/switch region; other site 405531013193 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405531013194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531013195 dimer interface [polypeptide binding]; other site 405531013196 conserved gate region; other site 405531013197 putative PBP binding loops; other site 405531013198 ABC-ATPase subunit interface; other site 405531013199 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 405531013200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531013201 motif II; other site 405531013202 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 405531013203 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 405531013204 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 405531013205 nudix motif; other site 405531013206 Tumour necrosis factor receptor superfamily member 19; Region: RELT; pfam12606 405531013207 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 405531013208 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531013209 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 405531013210 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405531013211 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531013212 DNA binding residues [nucleotide binding] 405531013213 dimer interface [polypeptide binding]; other site 405531013214 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405531013215 S-ribosylhomocysteinase; Provisional; Region: PRK02260 405531013216 Haemolytic domain; Region: Haemolytic; pfam01809 405531013217 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 405531013218 active site clefts [active] 405531013219 zinc binding site [ion binding]; other site 405531013220 dimer interface [polypeptide binding]; other site 405531013221 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405531013222 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405531013223 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 405531013224 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 405531013225 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405531013226 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405531013227 putative active site [active] 405531013228 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405531013229 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531013230 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531013231 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531013232 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531013233 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 405531013234 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 405531013235 Predicted membrane protein [Function unknown]; Region: COG3766 405531013236 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 405531013237 hypothetical protein; Provisional; Region: PRK12473 405531013238 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 405531013239 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405531013240 G1 box; other site 405531013241 GTP/Mg2+ binding site [chemical binding]; other site 405531013242 Switch I region; other site 405531013243 G2 box; other site 405531013244 G3 box; other site 405531013245 Switch II region; other site 405531013246 G4 box; other site 405531013247 G5 box; other site 405531013248 Nucleoside recognition; Region: Gate; pfam07670 405531013249 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405531013250 Nucleoside recognition; Region: Gate; pfam07670 405531013251 FeoA domain; Region: FeoA; pfam04023 405531013252 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 405531013253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531013254 dimerization interface [polypeptide binding]; other site 405531013255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531013256 dimer interface [polypeptide binding]; other site 405531013257 phosphorylation site [posttranslational modification] 405531013258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013259 ATP binding site [chemical binding]; other site 405531013260 Mg2+ binding site [ion binding]; other site 405531013261 G-X-G motif; other site 405531013262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531013263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531013264 active site 405531013265 phosphorylation site [posttranslational modification] 405531013266 intermolecular recognition site; other site 405531013267 dimerization interface [polypeptide binding]; other site 405531013268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531013269 DNA binding site [nucleotide binding] 405531013270 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 405531013271 active site 405531013272 catalytic site [active] 405531013273 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531013274 active site 405531013275 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 405531013276 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405531013277 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 405531013278 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 405531013279 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 405531013280 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 405531013281 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531013282 Cold-inducible protein YdjO; Region: YdjO; pfam14169 405531013283 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531013284 FtsX-like permease family; Region: FtsX; pfam02687 405531013285 rod shape-determining protein MreC; Provisional; Region: PRK13922 405531013286 rod shape-determining protein MreC; Region: MreC; pfam04085 405531013287 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531013288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531013289 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531013290 dimerization interface [polypeptide binding]; other site 405531013291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531013292 dimer interface [polypeptide binding]; other site 405531013293 phosphorylation site [posttranslational modification] 405531013294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013295 ATP binding site [chemical binding]; other site 405531013296 Mg2+ binding site [ion binding]; other site 405531013297 G-X-G motif; other site 405531013298 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531013299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531013300 active site 405531013301 phosphorylation site [posttranslational modification] 405531013302 intermolecular recognition site; other site 405531013303 dimerization interface [polypeptide binding]; other site 405531013304 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531013305 DNA binding site [nucleotide binding] 405531013306 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531013307 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531013308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531013309 S-adenosylmethionine binding site [chemical binding]; other site 405531013310 FtsX-like permease family; Region: FtsX; pfam02687 405531013311 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531013312 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531013313 Walker A/P-loop; other site 405531013314 ATP binding site [chemical binding]; other site 405531013315 Q-loop/lid; other site 405531013316 ABC transporter signature motif; other site 405531013317 Walker B; other site 405531013318 D-loop; other site 405531013319 H-loop/switch region; other site 405531013320 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405531013321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405531013322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405531013323 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405531013324 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531013325 Walker A/P-loop; other site 405531013326 ATP binding site [chemical binding]; other site 405531013327 Q-loop/lid; other site 405531013328 ABC transporter signature motif; other site 405531013329 Walker B; other site 405531013330 D-loop; other site 405531013331 H-loop/switch region; other site 405531013332 Predicted integral membrane protein [Function unknown]; Region: COG5658 405531013333 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 405531013334 SdpI/YhfL protein family; Region: SdpI; pfam13630 405531013335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531013336 dimerization interface [polypeptide binding]; other site 405531013337 putative DNA binding site [nucleotide binding]; other site 405531013338 putative Zn2+ binding site [ion binding]; other site 405531013339 RNA polymerase sigma factor; Provisional; Region: PRK12543 405531013340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531013341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531013342 active site 405531013343 phosphorylation site [posttranslational modification] 405531013344 intermolecular recognition site; other site 405531013345 dimerization interface [polypeptide binding]; other site 405531013346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531013347 DNA binding site [nucleotide binding] 405531013348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531013349 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 405531013350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013351 ATP binding site [chemical binding]; other site 405531013352 Mg2+ binding site [ion binding]; other site 405531013353 G-X-G motif; other site 405531013354 FtsX-like permease family; Region: FtsX; pfam02687 405531013355 FtsX-like permease family; Region: FtsX; pfam02687 405531013356 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531013357 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531013358 Walker A/P-loop; other site 405531013359 ATP binding site [chemical binding]; other site 405531013360 Q-loop/lid; other site 405531013361 ABC transporter signature motif; other site 405531013362 Walker B; other site 405531013363 D-loop; other site 405531013364 H-loop/switch region; other site 405531013365 GntP family permease; Region: GntP_permease; pfam02447 405531013366 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405531013367 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405531013368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405531013369 DNA-binding site [nucleotide binding]; DNA binding site 405531013370 UTRA domain; Region: UTRA; pfam07702 405531013371 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405531013372 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405531013373 substrate binding site [chemical binding]; other site 405531013374 ATP binding site [chemical binding]; other site 405531013375 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 405531013376 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405531013377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531013378 catalytic residue [active] 405531013379 probable amidohydrolase EF_0837/AHA_3915; Region: EF_0837; TIGR03583 405531013380 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 405531013381 active site 405531013382 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 405531013383 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 405531013384 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 405531013385 dimerization interface [polypeptide binding]; other site 405531013386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531013387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531013388 dimer interface [polypeptide binding]; other site 405531013389 phosphorylation site [posttranslational modification] 405531013390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013391 ATP binding site [chemical binding]; other site 405531013392 Mg2+ binding site [ion binding]; other site 405531013393 G-X-G motif; other site 405531013394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531013395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531013396 active site 405531013397 phosphorylation site [posttranslational modification] 405531013398 intermolecular recognition site; other site 405531013399 dimerization interface [polypeptide binding]; other site 405531013400 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531013401 DNA binding site [nucleotide binding] 405531013402 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 405531013403 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 405531013404 active site 405531013405 octamer interface [polypeptide binding]; other site 405531013406 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 405531013407 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 405531013408 acyl-activating enzyme (AAE) consensus motif; other site 405531013409 putative AMP binding site [chemical binding]; other site 405531013410 putative active site [active] 405531013411 putative CoA binding site [chemical binding]; other site 405531013412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405531013413 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 405531013414 substrate binding site [chemical binding]; other site 405531013415 oxyanion hole (OAH) forming residues; other site 405531013416 trimer interface [polypeptide binding]; other site 405531013417 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 405531013418 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405531013419 nucleophilic elbow; other site 405531013420 catalytic triad; other site 405531013421 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 405531013422 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 405531013423 dimer interface [polypeptide binding]; other site 405531013424 tetramer interface [polypeptide binding]; other site 405531013425 PYR/PP interface [polypeptide binding]; other site 405531013426 TPP binding site [chemical binding]; other site 405531013427 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 405531013428 TPP-binding site; other site 405531013429 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 405531013430 chorismate binding enzyme; Region: Chorismate_bind; cl10555 405531013431 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 405531013432 UbiA prenyltransferase family; Region: UbiA; pfam01040 405531013433 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 405531013434 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531013435 DNA-binding site [nucleotide binding]; DNA binding site 405531013436 RNA-binding motif; other site 405531013437 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 405531013438 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405531013439 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531013440 DNA binding residues [nucleotide binding] 405531013441 dimer interface [polypeptide binding]; other site 405531013442 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405531013443 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 405531013444 active site flap/lid [active] 405531013445 nucleophilic elbow; other site 405531013446 catalytic triad [active] 405531013447 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 405531013448 homodimer interface [polypeptide binding]; other site 405531013449 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 405531013450 active site pocket [active] 405531013451 glycogen synthase; Provisional; Region: glgA; PRK00654 405531013452 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 405531013453 ADP-binding pocket [chemical binding]; other site 405531013454 homodimer interface [polypeptide binding]; other site 405531013455 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 405531013456 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405531013457 ligand binding site; other site 405531013458 oligomer interface; other site 405531013459 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405531013460 dimer interface [polypeptide binding]; other site 405531013461 N-terminal domain interface [polypeptide binding]; other site 405531013462 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 405531013463 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405531013464 ligand binding site; other site 405531013465 oligomer interface; other site 405531013466 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405531013467 dimer interface [polypeptide binding]; other site 405531013468 N-terminal domain interface [polypeptide binding]; other site 405531013469 sulfate 1 binding site; other site 405531013470 glycogen branching enzyme; Provisional; Region: PRK12313 405531013471 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 405531013472 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 405531013473 active site 405531013474 catalytic site [active] 405531013475 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405531013476 Camelysin metallo-endopeptidase; Region: Peptidase_M73; cl13780 405531013477 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405531013478 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405531013479 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531013480 NAD binding site [chemical binding]; other site 405531013481 dimer interface [polypeptide binding]; other site 405531013482 substrate binding site [chemical binding]; other site 405531013483 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531013484 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531013485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013486 putative substrate translocation pore; other site 405531013487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531013488 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 405531013489 MgtC family; Region: MgtC; pfam02308 405531013490 Ion channel; Region: Ion_trans_2; pfam07885 405531013491 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 405531013492 TrkA-N domain; Region: TrkA_N; pfam02254 405531013493 YugN-like family; Region: YugN; pfam08868 405531013494 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 405531013495 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 405531013496 active site 405531013497 dimer interface [polypeptide binding]; other site 405531013498 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 405531013499 dimer interface [polypeptide binding]; other site 405531013500 active site 405531013501 Domain of unknown function (DUF378); Region: DUF378; pfam04070 405531013502 general stress protein 13; Validated; Region: PRK08059 405531013503 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405531013504 RNA binding site [nucleotide binding]; other site 405531013505 hypothetical protein; Validated; Region: PRK07682 405531013506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531013507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531013508 homodimer interface [polypeptide binding]; other site 405531013509 catalytic residue [active] 405531013510 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405531013511 AsnC family; Region: AsnC_trans_reg; pfam01037 405531013512 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 405531013513 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 405531013514 dimerization interface [polypeptide binding]; other site 405531013515 ligand binding site [chemical binding]; other site 405531013516 NADP binding site [chemical binding]; other site 405531013517 catalytic site [active] 405531013518 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 405531013519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531013520 nucleophilic elbow; other site 405531013521 catalytic triad; other site 405531013522 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 405531013523 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405531013524 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405531013525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531013526 homodimer interface [polypeptide binding]; other site 405531013527 catalytic residue [active] 405531013528 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 405531013529 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 405531013530 E-class dimer interface [polypeptide binding]; other site 405531013531 P-class dimer interface [polypeptide binding]; other site 405531013532 active site 405531013533 Cu2+ binding site [ion binding]; other site 405531013534 Zn2+ binding site [ion binding]; other site 405531013535 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 405531013536 Kinase associated protein B; Region: KapB; pfam08810 405531013537 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 405531013538 active site 405531013539 catalytic site [active] 405531013540 substrate binding site [chemical binding]; other site 405531013541 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 405531013542 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 405531013543 transmembrane helices; other site 405531013544 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 405531013545 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 405531013546 active site 405531013547 glycyl-tRNA synthetase; Provisional; Region: PRK04173 405531013548 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405531013549 motif 1; other site 405531013550 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 405531013551 active site 405531013552 motif 2; other site 405531013553 motif 3; other site 405531013554 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 405531013555 anticodon binding site; other site 405531013556 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405531013557 CoenzymeA binding site [chemical binding]; other site 405531013558 subunit interaction site [polypeptide binding]; other site 405531013559 PHB binding site; other site 405531013560 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 405531013561 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 405531013562 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 405531013563 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405531013564 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405531013565 active site 405531013566 tetramer interface; other site 405531013567 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 405531013568 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 405531013569 active site 405531013570 substrate binding site [chemical binding]; other site 405531013571 metal binding site [ion binding]; metal-binding site 405531013572 Bacterial membrane-spanning protein N-terminus; Region: YojJ; pfam10372 405531013573 Uncharacterized conserved protein [Function unknown]; Region: COG1624 405531013574 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 405531013575 multifunctional aminopeptidase A; Provisional; Region: PRK00913 405531013576 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 405531013577 interface (dimer of trimers) [polypeptide binding]; other site 405531013578 Substrate-binding/catalytic site; other site 405531013579 Zn-binding sites [ion binding]; other site 405531013580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405531013581 Putative membrane protein; Region: YuiB; pfam14068 405531013582 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 405531013583 nudix motif; other site 405531013584 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405531013585 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531013586 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 405531013587 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531013588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531013589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 405531013590 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531013591 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013592 putative substrate translocation pore; other site 405531013593 Helix-turn-helix domain; Region: HTH_36; pfam13730 405531013594 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405531013595 Uncharacterized conserved protein [Function unknown]; Region: COG1683 405531013596 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531013597 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 405531013598 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531013599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531013600 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 405531013601 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 405531013602 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405531013603 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405531013604 hypothetical protein; Provisional; Region: PRK13669 405531013605 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405531013606 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531013607 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 405531013608 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531013609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531013610 Walker A/P-loop; other site 405531013611 ATP binding site [chemical binding]; other site 405531013612 Q-loop/lid; other site 405531013613 ABC transporter signature motif; other site 405531013614 Walker B; other site 405531013615 D-loop; other site 405531013616 H-loop/switch region; other site 405531013617 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 405531013618 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 405531013619 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 405531013620 PhnA protein; Region: PhnA; pfam03831 405531013621 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 405531013622 PQQ-like domain; Region: PQQ_2; pfam13360 405531013623 PQQ-like domain; Region: PQQ_2; pfam13360 405531013624 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 405531013625 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 405531013626 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 405531013627 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405531013628 active site 405531013629 NTP binding site [chemical binding]; other site 405531013630 metal binding triad [ion binding]; metal-binding site 405531013631 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 405531013632 NifU-like domain; Region: NifU; pfam01106 405531013633 spore coat protein YutH; Region: spore_yutH; TIGR02905 405531013634 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 405531013635 tetramer interfaces [polypeptide binding]; other site 405531013636 binuclear metal-binding site [ion binding]; other site 405531013637 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531013638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531013639 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 405531013640 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531013641 active site 405531013642 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 405531013643 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 405531013644 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 405531013645 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 405531013646 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405531013647 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 405531013648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531013649 active site 405531013650 motif I; other site 405531013651 motif II; other site 405531013652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531013653 Predicted transcriptional regulator [Transcription]; Region: COG2345 405531013654 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531013655 putative Zn2+ binding site [ion binding]; other site 405531013656 putative DNA binding site [nucleotide binding]; other site 405531013657 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 405531013658 Uncharacterized conserved protein [Function unknown]; Region: COG2445 405531013659 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405531013660 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405531013661 putative active site [active] 405531013662 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 405531013663 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 405531013664 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531013665 RNA binding surface [nucleotide binding]; other site 405531013666 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 405531013667 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 405531013668 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531013669 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405531013670 DNA binding residues [nucleotide binding] 405531013671 dimer interface [polypeptide binding]; other site 405531013672 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405531013673 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 405531013674 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405531013675 catalytic core [active] 405531013676 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 405531013677 putative deacylase active site [active] 405531013678 lipoyl synthase; Provisional; Region: PRK05481 405531013679 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531013680 FeS/SAM binding site; other site 405531013681 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531013682 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531013683 sporulation protein YunB; Region: spo_yunB; TIGR02832 405531013684 Uncharacterized conserved protein [Function unknown]; Region: COG3377 405531013685 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405531013686 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 405531013687 active site 405531013688 metal binding site [ion binding]; metal-binding site 405531013689 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405531013690 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405531013691 FeS assembly protein SufB; Region: sufB; TIGR01980 405531013692 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 405531013693 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 405531013694 trimerization site [polypeptide binding]; other site 405531013695 active site 405531013696 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405531013697 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405531013698 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405531013699 catalytic residue [active] 405531013700 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 405531013701 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 405531013702 FeS assembly protein SufD; Region: sufD; TIGR01981 405531013703 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 405531013704 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 405531013705 Walker A/P-loop; other site 405531013706 ATP binding site [chemical binding]; other site 405531013707 Q-loop/lid; other site 405531013708 ABC transporter signature motif; other site 405531013709 Walker B; other site 405531013710 D-loop; other site 405531013711 H-loop/switch region; other site 405531013712 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405531013713 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405531013714 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 405531013715 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 405531013716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405531013717 ABC-ATPase subunit interface; other site 405531013718 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 405531013719 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405531013720 Walker A/P-loop; other site 405531013721 ATP binding site [chemical binding]; other site 405531013722 Q-loop/lid; other site 405531013723 ABC transporter signature motif; other site 405531013724 Walker B; other site 405531013725 D-loop; other site 405531013726 H-loop/switch region; other site 405531013727 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 405531013728 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531013729 catalytic residues [active] 405531013730 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 405531013731 putative active site [active] 405531013732 putative metal binding site [ion binding]; other site 405531013733 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 405531013734 lipoyl attachment site [posttranslational modification]; other site 405531013735 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 405531013736 ArsC family; Region: ArsC; pfam03960 405531013737 putative ArsC-like catalytic residues; other site 405531013738 putative TRX-like catalytic residues [active] 405531013739 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 405531013740 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 405531013741 active site 405531013742 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 405531013743 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405531013744 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 405531013745 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 405531013746 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531013747 NAD binding site [chemical binding]; other site 405531013748 dimer interface [polypeptide binding]; other site 405531013749 substrate binding site [chemical binding]; other site 405531013750 Coat F domain; Region: Coat_F; pfam07875 405531013751 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405531013752 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405531013753 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405531013754 active site 405531013755 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 405531013756 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405531013757 dimer interface [polypeptide binding]; other site 405531013758 active site 405531013759 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 405531013760 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405531013761 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405531013762 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405531013763 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405531013764 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 405531013765 substrate binding site [chemical binding]; other site 405531013766 oxyanion hole (OAH) forming residues; other site 405531013767 YuzL-like protein; Region: YuzL; pfam14115 405531013768 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531013769 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405531013770 Proline dehydrogenase; Region: Pro_dh; cl03282 405531013771 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 405531013772 Domain of unknown function DUF77; Region: DUF77; pfam01910 405531013773 Cache domain; Region: Cache_1; pfam02743 405531013774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531013775 dimerization interface [polypeptide binding]; other site 405531013776 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531013777 dimer interface [polypeptide binding]; other site 405531013778 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531013779 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531013780 dimer interface [polypeptide binding]; other site 405531013781 putative CheW interface [polypeptide binding]; other site 405531013782 Predicted transcriptional regulators [Transcription]; Region: COG1378 405531013783 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 405531013784 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 405531013785 C-terminal domain interface [polypeptide binding]; other site 405531013786 sugar binding site [chemical binding]; other site 405531013787 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405531013788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013789 putative substrate translocation pore; other site 405531013790 L-type amino acid transporter; Region: 2A0308; TIGR00911 405531013791 OxaA-like protein precursor; Validated; Region: PRK01622 405531013792 Uncharacterized conserved protein [Function unknown]; Region: COG1284 405531013793 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 405531013794 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 405531013795 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405531013796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531013797 hypothetical protein; Provisional; Region: PRK06758 405531013798 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 405531013799 active site 405531013800 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531013801 non-specific DNA binding site [nucleotide binding]; other site 405531013802 salt bridge; other site 405531013803 sequence-specific DNA binding site [nucleotide binding]; other site 405531013804 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531013805 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531013806 Protein of unknown function (DUF3978); Region: DUF3978; pfam13123 405531013807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 405531013808 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405531013809 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531013810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531013811 active site 405531013812 phosphorylation site [posttranslational modification] 405531013813 intermolecular recognition site; other site 405531013814 dimerization interface [polypeptide binding]; other site 405531013815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531013816 DNA binding site [nucleotide binding] 405531013817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531013818 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531013819 dimer interface [polypeptide binding]; other site 405531013820 phosphorylation site [posttranslational modification] 405531013821 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531013822 ATP binding site [chemical binding]; other site 405531013823 Mg2+ binding site [ion binding]; other site 405531013824 G-X-G motif; other site 405531013825 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405531013826 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 405531013827 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405531013828 active site 405531013829 HIGH motif; other site 405531013830 KMSKS motif; other site 405531013831 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405531013832 tRNA binding surface [nucleotide binding]; other site 405531013833 anticodon binding site; other site 405531013834 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531013835 S-adenosylmethionine binding site [chemical binding]; other site 405531013836 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405531013837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531013838 dimerization interface [polypeptide binding]; other site 405531013839 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531013840 dimer interface [polypeptide binding]; other site 405531013841 putative CheW interface [polypeptide binding]; other site 405531013842 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 405531013843 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531013844 dimerization interface [polypeptide binding]; other site 405531013845 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531013846 dimer interface [polypeptide binding]; other site 405531013847 putative CheW interface [polypeptide binding]; other site 405531013848 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 405531013849 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405531013850 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405531013851 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 405531013852 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405531013853 active site 405531013854 Zn binding site [ion binding]; other site 405531013855 Pirin-related protein [General function prediction only]; Region: COG1741 405531013856 Pirin; Region: Pirin; pfam02678 405531013857 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405531013858 MarR family; Region: MarR_2; pfam12802 405531013859 Protein of unknown function (DUF3920); Region: DUF3920; pfam13058 405531013860 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405531013861 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405531013862 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 405531013863 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 405531013864 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 405531013865 TrkA-C domain; Region: TrkA_C; pfam02080 405531013866 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531013867 amino acid carrier protein; Region: agcS; TIGR00835 405531013868 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405531013869 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405531013870 dimerization interface [polypeptide binding]; other site 405531013871 DPS ferroxidase diiron center [ion binding]; other site 405531013872 ion pore; other site 405531013873 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 405531013874 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 405531013875 metal binding site [ion binding]; metal-binding site 405531013876 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 405531013877 Ferritin-like domain; Region: Ferritin; pfam00210 405531013878 ferroxidase diiron center [ion binding]; other site 405531013879 Predicted membrane protein [Function unknown]; Region: COG2311 405531013880 Protein of unknown function (DUF418); Region: DUF418; cl12135 405531013881 Protein of unknown function (DUF418); Region: DUF418; pfam04235 405531013882 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405531013883 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405531013884 Nucleoside recognition; Region: Gate; pfam07670 405531013885 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405531013886 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531013887 amino acid carrier protein; Region: agcS; TIGR00835 405531013888 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405531013889 amino acid carrier protein; Region: agcS; TIGR00835 405531013890 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 405531013891 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405531013892 NAD binding site [chemical binding]; other site 405531013893 substrate binding site [chemical binding]; other site 405531013894 putative active site [active] 405531013895 Peptidase M60-like family; Region: M60-like; pfam13402 405531013896 Viral enhancin protein; Region: Enhancin; pfam03272 405531013897 TQXA domain; Region: TQXA_dom; TIGR03934 405531013898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405531013899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405531013900 active site 405531013901 catalytic tetrad [active] 405531013902 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405531013903 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013904 putative substrate translocation pore; other site 405531013905 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531013906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531013907 dimerization interface [polypeptide binding]; other site 405531013908 putative DNA binding site [nucleotide binding]; other site 405531013909 putative Zn2+ binding site [ion binding]; other site 405531013910 Uncharacterized conserved protein [Function unknown]; Region: COG2427 405531013911 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405531013912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531013913 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 405531013914 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 405531013915 active site 405531013916 HIGH motif; other site 405531013917 dimer interface [polypeptide binding]; other site 405531013918 KMSKS motif; other site 405531013919 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405531013920 RNA binding surface [nucleotide binding]; other site 405531013921 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK12436 405531013922 FAD binding domain; Region: FAD_binding_4; pfam01565 405531013923 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405531013924 SET domain; Region: SET; pfam00856 405531013925 Domain of unknown function (DUF4077); Region: DUF4077; pfam13295 405531013926 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531013927 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531013928 dimer interface [polypeptide binding]; other site 405531013929 putative CheW interface [polypeptide binding]; other site 405531013930 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 405531013931 putative phosphate binding site [ion binding]; other site 405531013932 camphor resistance protein CrcB; Provisional; Region: PRK14219 405531013933 camphor resistance protein CrcB; Provisional; Region: PRK14205 405531013934 Protein of unknown function (DUF3947); Region: DUF3947; pfam13135 405531013935 Protein of unknown function (DUF3955); Region: DUF3955; pfam13127 405531013936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013937 H+ Antiporter protein; Region: 2A0121; TIGR00900 405531013938 putative substrate translocation pore; other site 405531013939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531013940 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531013941 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531013942 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531013943 ABC transporter; Region: ABC_tran_2; pfam12848 405531013944 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531013945 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405531013946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405531013947 Coenzyme A binding pocket [chemical binding]; other site 405531013948 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 405531013949 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405531013950 Nuclease-related domain; Region: NERD; pfam08378 405531013951 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 405531013952 Isochorismatase family; Region: Isochorismatase; pfam00857 405531013953 catalytic triad [active] 405531013954 conserved cis-peptide bond; other site 405531013955 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405531013956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531013957 putative DNA binding site [nucleotide binding]; other site 405531013958 putative Zn2+ binding site [ion binding]; other site 405531013959 AsnC family; Region: AsnC_trans_reg; pfam01037 405531013960 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 405531013961 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 405531013962 AsnC family; Region: AsnC_trans_reg; pfam01037 405531013963 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 405531013964 active site clefts [active] 405531013965 zinc binding site [ion binding]; other site 405531013966 dimer interface [polypeptide binding]; other site 405531013967 cyanate hydratase; Validated; Region: PRK02866 405531013968 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 405531013969 oligomer interface [polypeptide binding]; other site 405531013970 active site 405531013971 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405531013972 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 405531013973 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 405531013974 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405531013975 Walker A/P-loop; other site 405531013976 ATP binding site [chemical binding]; other site 405531013977 Q-loop/lid; other site 405531013978 ABC transporter signature motif; other site 405531013979 Walker B; other site 405531013980 D-loop; other site 405531013981 H-loop/switch region; other site 405531013982 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531013983 ABC-ATPase subunit interface; other site 405531013984 dimer interface [polypeptide binding]; other site 405531013985 putative PBP binding regions; other site 405531013986 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405531013987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531013988 ABC-ATPase subunit interface; other site 405531013989 dimer interface [polypeptide binding]; other site 405531013990 putative PBP binding regions; other site 405531013991 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 405531013992 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405531013993 intersubunit interface [polypeptide binding]; other site 405531013994 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531013995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531013996 active site 405531013997 phosphorylation site [posttranslational modification] 405531013998 intermolecular recognition site; other site 405531013999 dimerization interface [polypeptide binding]; other site 405531014000 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531014001 DNA binding site [nucleotide binding] 405531014002 Protein of unknown function (DUF402); Region: DUF402; pfam04167 405531014003 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 405531014004 SmpB-tmRNA interface; other site 405531014005 ribonuclease R; Region: RNase_R; TIGR02063 405531014006 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405531014007 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405531014008 RNB domain; Region: RNB; pfam00773 405531014009 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 405531014010 RNA binding site [nucleotide binding]; other site 405531014011 Esterase/lipase [General function prediction only]; Region: COG1647 405531014012 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 405531014013 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405531014014 holin-like protein; Validated; Region: PRK01658 405531014015 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 405531014016 active site 405531014017 enolase; Provisional; Region: eno; PRK00077 405531014018 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 405531014019 dimer interface [polypeptide binding]; other site 405531014020 metal binding site [ion binding]; metal-binding site 405531014021 substrate binding pocket [chemical binding]; other site 405531014022 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 405531014023 phosphoglyceromutase; Provisional; Region: PRK05434 405531014024 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 405531014025 triosephosphate isomerase; Provisional; Region: PRK14565 405531014026 substrate binding site [chemical binding]; other site 405531014027 dimer interface [polypeptide binding]; other site 405531014028 catalytic triad [active] 405531014029 Phosphoglycerate kinase; Region: PGK; pfam00162 405531014030 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 405531014031 substrate binding site [chemical binding]; other site 405531014032 hinge regions; other site 405531014033 ADP binding site [chemical binding]; other site 405531014034 catalytic site [active] 405531014035 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 405531014036 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405531014037 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405531014038 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405531014039 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405531014040 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 405531014041 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 405531014042 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 405531014043 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 405531014044 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 405531014045 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405531014046 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 405531014047 stage V sporulation protein AD; Provisional; Region: PRK12404 405531014048 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 405531014049 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 405531014050 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405531014051 Predicted membrane protein [Function unknown]; Region: COG2323 405531014052 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 405531014053 Clp protease; Region: CLP_protease; pfam00574 405531014054 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405531014055 oligomer interface [polypeptide binding]; other site 405531014056 active site residues [active] 405531014057 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405531014058 dimerization domain swap beta strand [polypeptide binding]; other site 405531014059 regulatory protein interface [polypeptide binding]; other site 405531014060 active site 405531014061 regulatory phosphorylation site [posttranslational modification]; other site 405531014062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 405531014063 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 405531014064 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 405531014065 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 405531014066 phosphate binding site [ion binding]; other site 405531014067 putative substrate binding pocket [chemical binding]; other site 405531014068 dimer interface [polypeptide binding]; other site 405531014069 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 405531014070 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 405531014071 putative active site [active] 405531014072 nucleotide binding site [chemical binding]; other site 405531014073 nudix motif; other site 405531014074 putative metal binding site [ion binding]; other site 405531014075 Domain of unknown function (DUF368); Region: DUF368; pfam04018 405531014076 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 405531014077 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405531014078 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405531014079 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531014080 binding surface 405531014081 TPR motif; other site 405531014082 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531014083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405531014084 binding surface 405531014085 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405531014086 TPR motif; other site 405531014087 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405531014088 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405531014089 trimer interface [polypeptide binding]; other site 405531014090 active site 405531014091 substrate binding site [chemical binding]; other site 405531014092 CoA binding site [chemical binding]; other site 405531014093 pyrophosphatase PpaX; Provisional; Region: PRK13288 405531014094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531014095 active site 405531014096 motif I; other site 405531014097 motif II; other site 405531014098 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 405531014099 HPr kinase/phosphorylase; Provisional; Region: PRK05428 405531014100 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 405531014101 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 405531014102 Hpr binding site; other site 405531014103 active site 405531014104 homohexamer subunit interaction site [polypeptide binding]; other site 405531014105 Predicted membrane protein [Function unknown]; Region: COG1950 405531014106 Domain of unknown function (DUF4275); Region: DUF4275; pfam14101 405531014107 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 405531014108 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405531014109 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405531014110 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 405531014111 excinuclease ABC subunit B; Provisional; Region: PRK05298 405531014112 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531014113 ATP binding site [chemical binding]; other site 405531014114 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531014115 nucleotide binding region [chemical binding]; other site 405531014116 ATP-binding site [chemical binding]; other site 405531014117 Ultra-violet resistance protein B; Region: UvrB; pfam12344 405531014118 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 405531014119 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 405531014120 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531014121 DNA binding residues [nucleotide binding] 405531014122 dimer interface [polypeptide binding]; other site 405531014123 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 405531014124 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531014125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531014126 non-specific DNA binding site [nucleotide binding]; other site 405531014127 salt bridge; other site 405531014128 sequence-specific DNA binding site [nucleotide binding]; other site 405531014129 Predicted membrane protein [Function unknown]; Region: COG2855 405531014130 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531014131 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531014132 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 405531014133 putative dimerization interface [polypeptide binding]; other site 405531014134 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 405531014135 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531014136 DNA binding residues [nucleotide binding] 405531014137 putative dimer interface [polypeptide binding]; other site 405531014138 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 405531014139 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405531014140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531014141 D-loop; other site 405531014142 H-loop/switch region; other site 405531014143 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 405531014144 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 405531014145 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405531014146 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405531014147 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405531014148 Walker A/P-loop; other site 405531014149 ATP binding site [chemical binding]; other site 405531014150 Q-loop/lid; other site 405531014151 ABC transporter signature motif; other site 405531014152 Walker B; other site 405531014153 D-loop; other site 405531014154 H-loop/switch region; other site 405531014155 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405531014156 protein binding site [polypeptide binding]; other site 405531014157 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 405531014158 C-terminal peptidase (prc); Region: prc; TIGR00225 405531014159 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 405531014160 protein binding site [polypeptide binding]; other site 405531014161 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 405531014162 Catalytic dyad [active] 405531014163 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405531014164 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 405531014165 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 405531014166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531014167 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 405531014168 Walker A/P-loop; other site 405531014169 ATP binding site [chemical binding]; other site 405531014170 Q-loop/lid; other site 405531014171 ABC transporter signature motif; other site 405531014172 Walker B; other site 405531014173 D-loop; other site 405531014174 H-loop/switch region; other site 405531014175 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 405531014176 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 405531014177 peptide chain release factor 2; Provisional; Region: PRK06746 405531014178 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405531014179 RF-1 domain; Region: RF-1; pfam00472 405531014180 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 405531014181 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405531014182 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 405531014183 nucleotide binding region [chemical binding]; other site 405531014184 ATP-binding site [chemical binding]; other site 405531014185 SEC-C motif; Region: SEC-C; pfam02810 405531014186 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 405531014187 30S subunit binding site; other site 405531014188 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 405531014189 DNA-binding site [nucleotide binding]; DNA binding site 405531014190 RNA-binding motif; other site 405531014191 comF family protein; Region: comF; TIGR00201 405531014192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531014193 active site 405531014194 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 405531014195 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531014196 ATP binding site [chemical binding]; other site 405531014197 putative Mg++ binding site [ion binding]; other site 405531014198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531014199 nucleotide binding region [chemical binding]; other site 405531014200 ATP-binding site [chemical binding]; other site 405531014201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 405531014202 Cortexillin I, coiled coil; Region: Cortex-I_coil; pfam09304 405531014203 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405531014204 NlpC/P60 family; Region: NLPC_P60; pfam00877 405531014205 Predicted transcriptional regulators [Transcription]; Region: COG1733 405531014206 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531014207 dimerization interface [polypeptide binding]; other site 405531014208 putative DNA binding site [nucleotide binding]; other site 405531014209 putative Zn2+ binding site [ion binding]; other site 405531014210 EDD domain protein, DegV family; Region: DegV; TIGR00762 405531014211 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 405531014212 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 405531014213 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 405531014214 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 405531014215 Transcriptional regulator [Transcription]; Region: LytR; COG1316 405531014216 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 405531014217 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405531014218 active site 405531014219 homodimer interface [polypeptide binding]; other site 405531014220 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 405531014221 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405531014222 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405531014223 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405531014224 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 405531014225 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 405531014226 Mg++ binding site [ion binding]; other site 405531014227 putative catalytic motif [active] 405531014228 substrate binding site [chemical binding]; other site 405531014229 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 405531014230 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 405531014231 NodB motif; other site 405531014232 active site 405531014233 catalytic site [active] 405531014234 Zn binding site [ion binding]; other site 405531014235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531014236 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405531014237 Walker A motif; other site 405531014238 ATP binding site [chemical binding]; other site 405531014239 Walker B motif; other site 405531014240 arginine finger; other site 405531014241 Transcriptional antiterminator [Transcription]; Region: COG3933 405531014242 PRD domain; Region: PRD; pfam00874 405531014243 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405531014244 active pocket/dimerization site; other site 405531014245 active site 405531014246 phosphorylation site [posttranslational modification] 405531014247 PRD domain; Region: PRD; pfam00874 405531014248 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 405531014249 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 405531014250 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 405531014251 Chromate transporter; Region: Chromate_transp; pfam02417 405531014252 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 405531014253 putative active site [active] 405531014254 YdjC motif; other site 405531014255 Mg binding site [ion binding]; other site 405531014256 putative homodimer interface [polypeptide binding]; other site 405531014257 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 405531014258 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 405531014259 NAD binding site [chemical binding]; other site 405531014260 sugar binding site [chemical binding]; other site 405531014261 divalent metal binding site [ion binding]; other site 405531014262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531014263 dimer interface [polypeptide binding]; other site 405531014264 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405531014265 active site 405531014266 methionine cluster; other site 405531014267 phosphorylation site [posttranslational modification] 405531014268 metal binding site [ion binding]; metal-binding site 405531014269 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405531014270 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405531014271 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405531014272 active site 405531014273 P-loop; other site 405531014274 phosphorylation site [posttranslational modification] 405531014275 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531014276 S-adenosylmethionine binding site [chemical binding]; other site 405531014277 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 405531014278 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405531014279 methionine cluster; other site 405531014280 active site 405531014281 phosphorylation site [posttranslational modification] 405531014282 metal binding site [ion binding]; metal-binding site 405531014283 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405531014284 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 405531014285 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405531014286 active site 405531014287 P-loop; other site 405531014288 phosphorylation site [posttranslational modification] 405531014289 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 405531014290 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405531014291 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405531014292 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 405531014293 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405531014294 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 405531014295 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 405531014296 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 405531014297 Predicted membrane protein [Function unknown]; Region: COG1511 405531014298 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 405531014299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405531014300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405531014301 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 405531014302 putative dimerization interface [polypeptide binding]; other site 405531014303 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 405531014304 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 405531014305 arsenical pump membrane protein; Provisional; Region: PRK15445 405531014306 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 405531014307 transmembrane helices; other site 405531014308 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 405531014309 ThiC-associated domain; Region: ThiC-associated; pfam13667 405531014310 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 405531014311 L-lactate permease; Region: Lactate_perm; cl00701 405531014312 glycolate transporter; Provisional; Region: PRK09695 405531014313 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; pfam09988 405531014314 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 405531014315 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405531014316 Sulfatase; Region: Sulfatase; pfam00884 405531014317 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 405531014318 homodimer interface [polypeptide binding]; other site 405531014319 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405531014320 substrate-cofactor binding pocket; other site 405531014321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531014322 catalytic residue [active] 405531014323 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014324 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014325 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014326 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014327 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014328 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405531014329 NlpC/P60 family; Region: NLPC_P60; pfam00877 405531014330 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405531014331 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405531014332 Nucleoside recognition; Region: Gate; pfam07670 405531014333 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405531014334 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 405531014335 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405531014336 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405531014337 DXD motif; other site 405531014338 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 405531014339 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405531014340 putative active site [active] 405531014341 putative NTP binding site [chemical binding]; other site 405531014342 putative nucleic acid binding site [nucleotide binding]; other site 405531014343 Type II intron maturase; Region: Intron_maturas2; pfam01348 405531014344 Group II catalytic intron 405531014345 BCCT family transporter; Region: BCCT; pfam02028 405531014346 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014347 Bacterial SH3 domain; Region: SH3_3; pfam08239 405531014348 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 405531014349 Protein of unknown function (DUF3910); Region: DUF3910; pfam13049 405531014350 Predicted membrane protein [Function unknown]; Region: COG4640 405531014351 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 405531014352 Double zinc ribbon; Region: DZR; pfam12773 405531014353 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 405531014354 Double zinc ribbon; Region: DZR; pfam12773 405531014355 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 405531014356 SNF2 Helicase protein; Region: DUF3670; pfam12419 405531014357 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 405531014358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405531014359 ATP binding site [chemical binding]; other site 405531014360 putative Mg++ binding site [ion binding]; other site 405531014361 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531014362 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 405531014363 nucleotide binding region [chemical binding]; other site 405531014364 ATP-binding site [chemical binding]; other site 405531014365 Predicted integral membrane protein [Function unknown]; Region: COG5652 405531014366 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 405531014367 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 405531014368 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 405531014369 ComK protein; Region: ComK; cl11560 405531014370 RNA polymerase factor sigma-70; Validated; Region: PRK06759 405531014371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531014372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531014373 DNA binding residues [nucleotide binding] 405531014374 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 405531014375 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405531014376 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 405531014377 FtsX-like permease family; Region: FtsX; pfam02687 405531014378 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405531014379 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405531014380 Walker A/P-loop; other site 405531014381 ATP binding site [chemical binding]; other site 405531014382 Q-loop/lid; other site 405531014383 ABC transporter signature motif; other site 405531014384 Walker B; other site 405531014385 D-loop; other site 405531014386 H-loop/switch region; other site 405531014387 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405531014388 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405531014389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531014390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531014391 non-specific DNA binding site [nucleotide binding]; other site 405531014392 salt bridge; other site 405531014393 sequence-specific DNA binding site [nucleotide binding]; other site 405531014394 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 405531014395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531014396 putative substrate translocation pore; other site 405531014397 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405531014398 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405531014399 Protein of unknown function (DUF3919); Region: DUF3919; pfam13057 405531014400 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405531014401 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531014402 dimerization interface [polypeptide binding]; other site 405531014403 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531014404 dimer interface [polypeptide binding]; other site 405531014405 phosphorylation site [posttranslational modification] 405531014406 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531014407 ATP binding site [chemical binding]; other site 405531014408 Mg2+ binding site [ion binding]; other site 405531014409 G-X-G motif; other site 405531014410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531014411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531014412 active site 405531014413 phosphorylation site [posttranslational modification] 405531014414 intermolecular recognition site; other site 405531014415 dimerization interface [polypeptide binding]; other site 405531014416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531014417 DNA binding site [nucleotide binding] 405531014418 UDP-glucose 4-epimerase; Region: PLN02240 405531014419 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405531014420 NAD binding site [chemical binding]; other site 405531014421 homodimer interface [polypeptide binding]; other site 405531014422 active site 405531014423 substrate binding site [chemical binding]; other site 405531014424 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 405531014425 active site 405531014426 catalytic triad [active] 405531014427 membrane-bound transcriptional regulator LytR; Provisional; Region: PRK09379 405531014428 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405531014429 putative CoA binding site [chemical binding]; other site 405531014430 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 405531014431 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405531014432 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 405531014433 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405531014434 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405531014435 integral membrane protein MviN; Region: mviN; TIGR01695 405531014436 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 405531014437 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405531014438 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 405531014439 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 405531014440 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 405531014441 Bacterial sugar transferase; Region: Bac_transf; pfam02397 405531014442 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405531014443 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405531014444 active site 405531014445 tetramer interface; other site 405531014446 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 405531014447 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405531014448 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405531014449 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 405531014450 Chain length determinant protein; Region: Wzz; cl15801 405531014451 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 405531014452 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405531014453 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405531014454 rod shape-determining protein Mbl; Provisional; Region: PRK13928 405531014455 MreB and similar proteins; Region: MreB_like; cd10225 405531014456 nucleotide binding site [chemical binding]; other site 405531014457 Mg binding site [ion binding]; other site 405531014458 putative protofilament interaction site [polypeptide binding]; other site 405531014459 RodZ interaction site [polypeptide binding]; other site 405531014460 Stage III sporulation protein D; Region: SpoIIID; cl17560 405531014461 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531014462 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531014463 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405531014464 Protein of unknown function (DUF502); Region: DUF502; cl01107 405531014465 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531014466 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531014467 Walker A/P-loop; other site 405531014468 ATP binding site [chemical binding]; other site 405531014469 Q-loop/lid; other site 405531014470 ABC transporter signature motif; other site 405531014471 Walker B; other site 405531014472 D-loop; other site 405531014473 H-loop/switch region; other site 405531014474 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405531014475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531014476 Q-loop/lid; other site 405531014477 ABC transporter signature motif; other site 405531014478 Walker B; other site 405531014479 D-loop; other site 405531014480 H-loop/switch region; other site 405531014481 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405531014482 LytTr DNA-binding domain; Region: LytTR; pfam04397 405531014483 Stage II sporulation protein; Region: SpoIID; pfam08486 405531014484 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 405531014485 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405531014486 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405531014487 hinge; other site 405531014488 active site 405531014489 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 405531014490 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 405531014491 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 405531014492 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405531014493 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 405531014494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405531014495 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 405531014496 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 405531014497 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405531014498 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 405531014499 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 405531014500 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 405531014501 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 405531014502 4Fe-4S binding domain; Region: Fer4; cl02805 405531014503 4Fe-4S binding domain; Region: Fer4; pfam00037 405531014504 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 405531014505 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 405531014506 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 405531014507 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 405531014508 NADH dehydrogenase subunit C; Validated; Region: PRK07735 405531014509 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 405531014510 NADH dehydrogenase subunit B; Validated; Region: PRK06411 405531014511 NADH dehydrogenase subunit A; Validated; Region: PRK07756 405531014512 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 405531014513 PAS domain S-box; Region: sensory_box; TIGR00229 405531014514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531014515 putative active site [active] 405531014516 heme pocket [chemical binding]; other site 405531014517 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531014518 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531014519 metal binding site [ion binding]; metal-binding site 405531014520 active site 405531014521 I-site; other site 405531014522 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531014523 Protein of unknown function (DUF975); Region: DUF975; cl10504 405531014524 Protein of unknown function (DUF975); Region: DUF975; cl10504 405531014525 Protein of unknown function (DUF975); Region: DUF975; cl10504 405531014526 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 405531014527 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 405531014528 gamma subunit interface [polypeptide binding]; other site 405531014529 epsilon subunit interface [polypeptide binding]; other site 405531014530 LBP interface [polypeptide binding]; other site 405531014531 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 405531014532 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405531014533 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 405531014534 alpha subunit interaction interface [polypeptide binding]; other site 405531014535 Walker A motif; other site 405531014536 ATP binding site [chemical binding]; other site 405531014537 Walker B motif; other site 405531014538 inhibitor binding site; inhibition site 405531014539 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405531014540 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 405531014541 core domain interface [polypeptide binding]; other site 405531014542 delta subunit interface [polypeptide binding]; other site 405531014543 epsilon subunit interface [polypeptide binding]; other site 405531014544 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 405531014545 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405531014546 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 405531014547 beta subunit interaction interface [polypeptide binding]; other site 405531014548 Walker A motif; other site 405531014549 ATP binding site [chemical binding]; other site 405531014550 Walker B motif; other site 405531014551 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405531014552 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 405531014553 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 405531014554 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 405531014555 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 405531014556 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 405531014557 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 405531014558 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 405531014559 ATP synthase I chain; Region: ATP_synt_I; pfam03899 405531014560 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 405531014561 Protein of unknown function (DUF4024); Region: DUF4024; pfam13216 405531014562 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405531014563 active site 405531014564 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 405531014565 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 405531014566 dimer interface [polypeptide binding]; other site 405531014567 active site 405531014568 glycine-pyridoxal phosphate binding site [chemical binding]; other site 405531014569 folate binding site [chemical binding]; other site 405531014570 hypothetical protein; Provisional; Region: PRK13690 405531014571 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 405531014572 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 405531014573 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405531014574 active site 405531014575 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405531014576 HPr interaction site; other site 405531014577 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405531014578 active site 405531014579 phosphorylation site [posttranslational modification] 405531014580 Predicted membrane protein [Function unknown]; Region: COG2259 405531014581 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 405531014582 Protein of unknown function (DUF3935); Region: DUF3935; pfam13071 405531014583 Predicted membrane protein [Function unknown]; Region: COG1971 405531014584 Domain of unknown function DUF; Region: DUF204; pfam02659 405531014585 Domain of unknown function DUF; Region: DUF204; pfam02659 405531014586 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 405531014587 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 405531014588 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 405531014589 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 405531014590 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 405531014591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531014592 S-adenosylmethionine binding site [chemical binding]; other site 405531014593 peptide chain release factor 1; Validated; Region: prfA; PRK00591 405531014594 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405531014595 RF-1 domain; Region: RF-1; pfam00472 405531014596 thymidine kinase; Provisional; Region: PRK04296 405531014597 LabA_like proteins; Region: LabA_like/DUF88; cl10034 405531014598 putative metal binding site [ion binding]; other site 405531014599 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 405531014600 transcription termination factor Rho; Provisional; Region: rho; PRK09376 405531014601 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 405531014602 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 405531014603 RNA binding site [nucleotide binding]; other site 405531014604 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 405531014605 multimer interface [polypeptide binding]; other site 405531014606 Walker A motif; other site 405531014607 ATP binding site [chemical binding]; other site 405531014608 Walker B motif; other site 405531014609 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405531014610 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405531014611 putative active site [active] 405531014612 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405531014613 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405531014614 hinge; other site 405531014615 active site 405531014616 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405531014617 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405531014618 intersubunit interface [polypeptide binding]; other site 405531014619 active site 405531014620 zinc binding site [ion binding]; other site 405531014621 Na+ binding site [ion binding]; other site 405531014622 Response regulator receiver domain; Region: Response_reg; pfam00072 405531014623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531014624 active site 405531014625 phosphorylation site [posttranslational modification] 405531014626 intermolecular recognition site; other site 405531014627 dimerization interface [polypeptide binding]; other site 405531014628 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 405531014629 CTP synthetase; Validated; Region: pyrG; PRK05380 405531014630 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 405531014631 Catalytic site [active] 405531014632 active site 405531014633 UTP binding site [chemical binding]; other site 405531014634 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 405531014635 active site 405531014636 putative oxyanion hole; other site 405531014637 catalytic triad [active] 405531014638 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 405531014639 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531014640 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531014641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405531014642 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405531014643 FAD binding site [chemical binding]; other site 405531014644 homotetramer interface [polypeptide binding]; other site 405531014645 substrate binding pocket [chemical binding]; other site 405531014646 catalytic base [active] 405531014647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 405531014648 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 405531014649 FAD binding site [chemical binding]; other site 405531014650 homotetramer interface [polypeptide binding]; other site 405531014651 substrate binding pocket [chemical binding]; other site 405531014652 catalytic base [active] 405531014653 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 405531014654 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405531014655 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405531014656 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 405531014657 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405531014658 dimer interface [polypeptide binding]; other site 405531014659 active site 405531014660 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405531014661 4Fe-4S binding domain; Region: Fer4; cl02805 405531014662 Cysteine-rich domain; Region: CCG; pfam02754 405531014663 Cysteine-rich domain; Region: CCG; pfam02754 405531014664 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405531014665 PLD-like domain; Region: PLDc_2; pfam13091 405531014666 putative active site [active] 405531014667 catalytic site [active] 405531014668 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 405531014669 PLD-like domain; Region: PLDc_2; pfam13091 405531014670 putative active site [active] 405531014671 catalytic site [active] 405531014672 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 405531014673 Domain of unknown function (DUF4084); Region: DUF4084; pfam13321 405531014674 PAS domain S-box; Region: sensory_box; TIGR00229 405531014675 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531014676 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531014677 metal binding site [ion binding]; metal-binding site 405531014678 active site 405531014679 I-site; other site 405531014680 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405531014681 Bacillus PapR protein; Region: Bacillus_PapR; pfam05968 405531014682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531014683 non-specific DNA binding site [nucleotide binding]; other site 405531014684 salt bridge; other site 405531014685 sequence-specific DNA binding site [nucleotide binding]; other site 405531014686 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 405531014687 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 405531014688 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 405531014689 active site 405531014690 Zn binding site [ion binding]; other site 405531014691 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531014692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531014693 active site 405531014694 phosphorylation site [posttranslational modification] 405531014695 intermolecular recognition site; other site 405531014696 dimerization interface [polypeptide binding]; other site 405531014697 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531014698 DNA binding residues [nucleotide binding] 405531014699 dimerization interface [polypeptide binding]; other site 405531014700 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531014701 Histidine kinase; Region: HisKA_3; pfam07730 405531014702 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405531014703 ATP binding site [chemical binding]; other site 405531014704 Mg2+ binding site [ion binding]; other site 405531014705 G-X-G motif; other site 405531014706 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 405531014707 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405531014708 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531014709 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405531014710 Walker A/P-loop; other site 405531014711 ATP binding site [chemical binding]; other site 405531014712 Q-loop/lid; other site 405531014713 ABC transporter signature motif; other site 405531014714 Walker B; other site 405531014715 D-loop; other site 405531014716 H-loop/switch region; other site 405531014717 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405531014718 active site 405531014719 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405531014720 Collagen binding domain; Region: Collagen_bind; pfam05737 405531014721 Collagen binding domain; Region: Collagen_bind; pfam05737 405531014722 Collagen binding domain; Region: Collagen_bind; pfam05737 405531014723 Collagen binding domain; Region: Collagen_bind; pfam05737 405531014724 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014725 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014726 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014727 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014728 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014729 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014730 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014731 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405531014732 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014733 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014734 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014735 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014736 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405531014737 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014738 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014739 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014740 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014741 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014742 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 405531014743 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014744 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014745 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014746 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014747 Cna protein B-type domain; Region: Cna_B; pfam05738 405531014748 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405531014749 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 405531014750 PA/protease or protease-like domain interface [polypeptide binding]; other site 405531014751 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 405531014752 Peptidase family M28; Region: Peptidase_M28; pfam04389 405531014753 metal binding site [ion binding]; metal-binding site 405531014754 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 405531014755 RNA polymerase sigma factor; Provisional; Region: PRK12522 405531014756 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531014757 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531014758 DNA binding residues [nucleotide binding] 405531014759 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 405531014760 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405531014761 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405531014762 active site 405531014763 HIGH motif; other site 405531014764 KMSK motif region; other site 405531014765 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405531014766 tRNA binding surface [nucleotide binding]; other site 405531014767 anticodon binding site; other site 405531014768 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 405531014769 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 405531014770 putative dimer interface [polypeptide binding]; other site 405531014771 catalytic triad [active] 405531014772 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 405531014773 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 405531014774 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 405531014775 agmatinase; Region: agmatinase; TIGR01230 405531014776 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 405531014777 putative active site [active] 405531014778 Mn binding site [ion binding]; other site 405531014779 spermidine synthase; Provisional; Region: PRK00811 405531014780 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531014781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531014782 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405531014783 putative substrate translocation pore; other site 405531014784 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 405531014785 Helix-Turn-Helix DNA binding domain of the YfmP transcription regulator; Region: HTH_YfmP; cd04774 405531014786 DNA binding residues [nucleotide binding] 405531014787 putative dimer interface [polypeptide binding]; other site 405531014788 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 405531014789 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 405531014790 active site 405531014791 catalytic site [active] 405531014792 metal binding site [ion binding]; metal-binding site 405531014793 dimer interface [polypeptide binding]; other site 405531014794 Transglycosylase; Region: Transgly; pfam00912 405531014795 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 405531014796 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405531014797 YwhD family; Region: YwhD; pfam08741 405531014798 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 405531014799 Peptidase family M50; Region: Peptidase_M50; pfam02163 405531014800 active site 405531014801 putative substrate binding region [chemical binding]; other site 405531014802 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 405531014803 active site 1 [active] 405531014804 dimer interface [polypeptide binding]; other site 405531014805 hexamer interface [polypeptide binding]; other site 405531014806 active site 2 [active] 405531014807 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 405531014808 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405531014809 Zn2+ binding site [ion binding]; other site 405531014810 Mg2+ binding site [ion binding]; other site 405531014811 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405531014812 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405531014813 intersubunit interface [polypeptide binding]; other site 405531014814 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405531014815 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405531014816 Walker A/P-loop; other site 405531014817 ATP binding site [chemical binding]; other site 405531014818 Q-loop/lid; other site 405531014819 ABC transporter signature motif; other site 405531014820 Walker B; other site 405531014821 D-loop; other site 405531014822 H-loop/switch region; other site 405531014823 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531014824 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531014825 ABC-ATPase subunit interface; other site 405531014826 dimer interface [polypeptide binding]; other site 405531014827 putative PBP binding regions; other site 405531014828 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405531014829 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405531014830 ABC-ATPase subunit interface; other site 405531014831 dimer interface [polypeptide binding]; other site 405531014832 putative PBP binding regions; other site 405531014833 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 405531014834 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405531014835 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 405531014836 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405531014837 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 405531014838 putative heme peroxidase; Provisional; Region: PRK12276 405531014839 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405531014840 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405531014841 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405531014842 Cell wall hydrolyses involved in spore germination [Cell envelope biogenesis, outer membrane]; Region: SleB; COG3773 405531014843 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 405531014844 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 405531014845 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 405531014846 Ion channel; Region: Ion_trans_2; pfam07885 405531014847 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 405531014848 TrkA-N domain; Region: TrkA_N; pfam02254 405531014849 TrkA-C domain; Region: TrkA_C; pfam02080 405531014850 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405531014851 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 405531014852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531014853 motif II; other site 405531014854 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531014855 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 405531014856 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 405531014857 ligand binding site [chemical binding]; other site 405531014858 active site 405531014859 UGI interface [polypeptide binding]; other site 405531014860 catalytic site [active] 405531014861 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 405531014862 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 405531014863 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 405531014864 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405531014865 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 405531014866 Walker A/P-loop; other site 405531014867 ATP binding site [chemical binding]; other site 405531014868 Q-loop/lid; other site 405531014869 ABC transporter signature motif; other site 405531014870 Walker B; other site 405531014871 D-loop; other site 405531014872 H-loop/switch region; other site 405531014873 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 405531014874 active site 405531014875 catalytic triad [active] 405531014876 oxyanion hole [active] 405531014877 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405531014878 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405531014879 DNA binding site [nucleotide binding] 405531014880 domain linker motif; other site 405531014881 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 405531014882 putative dimerization interface [polypeptide binding]; other site 405531014883 putative ligand binding site [chemical binding]; other site 405531014884 Predicted membrane protein [Function unknown]; Region: COG2364 405531014885 homoserine dehydrogenase; Provisional; Region: PRK06349 405531014886 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405531014887 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405531014888 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 405531014889 homoserine O-succinyltransferase; Provisional; Region: PRK05368 405531014890 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 405531014891 proposed active site lysine [active] 405531014892 conserved cys residue [active] 405531014893 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06702 405531014894 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405531014895 homodimer interface [polypeptide binding]; other site 405531014896 substrate-cofactor binding pocket; other site 405531014897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405531014898 catalytic residue [active] 405531014899 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 405531014900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531014901 active site 405531014902 motif I; other site 405531014903 motif II; other site 405531014904 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405531014905 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405531014906 ligand binding site [chemical binding]; other site 405531014907 flexible hinge region; other site 405531014908 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405531014909 azoreductase; Provisional; Region: PRK13556 405531014910 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405531014911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531014912 active site 405531014913 phosphorylation site [posttranslational modification] 405531014914 intermolecular recognition site; other site 405531014915 dimerization interface [polypeptide binding]; other site 405531014916 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405531014917 DNA binding residues [nucleotide binding] 405531014918 dimerization interface [polypeptide binding]; other site 405531014919 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405531014920 GAF domain; Region: GAF; pfam01590 405531014921 GAF domain; Region: GAF_2; pfam13185 405531014922 GAF domain; Region: GAF_3; pfam13492 405531014923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 405531014924 Histidine kinase; Region: HisKA_3; pfam07730 405531014925 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 405531014926 ATP binding site [chemical binding]; other site 405531014927 Mg2+ binding site [ion binding]; other site 405531014928 G-X-G motif; other site 405531014929 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405531014930 dimer interface [polypeptide binding]; other site 405531014931 substrate binding site [chemical binding]; other site 405531014932 ATP binding site [chemical binding]; other site 405531014933 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405531014934 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405531014935 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405531014936 metal binding site [ion binding]; metal-binding site 405531014937 active site 405531014938 I-site; other site 405531014939 Protein of unknown function (DUF466); Region: DUF466; pfam04328 405531014940 carbon starvation protein A; Provisional; Region: PRK15015 405531014941 Carbon starvation protein CstA; Region: CstA; pfam02554 405531014942 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405531014943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531014944 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405531014945 active site 405531014946 phosphorylation site [posttranslational modification] 405531014947 intermolecular recognition site; other site 405531014948 dimerization interface [polypeptide binding]; other site 405531014949 LytTr DNA-binding domain; Region: LytTR; pfam04397 405531014950 benzoate transport; Region: 2A0115; TIGR00895 405531014951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531014952 putative substrate translocation pore; other site 405531014953 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405531014954 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405531014955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405531014956 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405531014957 Predicted membrane protein [Function unknown]; Region: COG2860 405531014958 UPF0126 domain; Region: UPF0126; pfam03458 405531014959 UPF0126 domain; Region: UPF0126; pfam03458 405531014960 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 405531014961 heme-binding site [chemical binding]; other site 405531014962 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405531014963 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405531014964 dimer interface [polypeptide binding]; other site 405531014965 putative CheW interface [polypeptide binding]; other site 405531014966 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405531014967 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405531014968 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531014969 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 405531014970 Ligand binding site; other site 405531014971 Putative Catalytic site; other site 405531014972 DXD motif; other site 405531014973 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 405531014974 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405531014975 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405531014976 active site 405531014977 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405531014978 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405531014979 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 405531014980 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 405531014981 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 405531014982 Ligand binding site; other site 405531014983 Putative Catalytic site; other site 405531014984 DXD motif; other site 405531014985 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531014986 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531014987 NAD(P) binding site [chemical binding]; other site 405531014988 active site 405531014989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531014990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531014991 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 405531014992 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531014993 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531014994 ABC transporter; Region: ABC_tran_2; pfam12848 405531014995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405531014996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405531014997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405531014998 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 405531014999 Protein export membrane protein; Region: SecD_SecF; cl14618 405531015000 methionine sulfoxide reductase A; Provisional; Region: PRK14054 405531015001 methionine sulfoxide reductase B; Provisional; Region: PRK00222 405531015002 SelR domain; Region: SelR; pfam01641 405531015003 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405531015004 antiholin-like protein LrgB; Provisional; Region: PRK04288 405531015005 murein hydrolase regulator LrgA; Provisional; Region: PRK04125 405531015006 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405531015007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531015008 active site 405531015009 phosphorylation site [posttranslational modification] 405531015010 intermolecular recognition site; other site 405531015011 dimerization interface [polypeptide binding]; other site 405531015012 LytTr DNA-binding domain; Region: LytTR; pfam04397 405531015013 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 405531015014 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405531015015 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405531015016 Histidine kinase; Region: His_kinase; pfam06580 405531015017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531015018 ATP binding site [chemical binding]; other site 405531015019 Mg2+ binding site [ion binding]; other site 405531015020 G-X-G motif; other site 405531015021 PyrR binding site 405531015022 benzoate transport; Region: 2A0115; TIGR00895 405531015023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405531015024 putative substrate translocation pore; other site 405531015025 BCCT family transporter; Region: BCCT; pfam02028 405531015026 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 405531015027 active site 405531015028 dimer interface [polypeptide binding]; other site 405531015029 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 405531015030 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405531015031 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405531015032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405531015033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405531015034 NAD(P) binding site [chemical binding]; other site 405531015035 active site 405531015036 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 405531015037 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405531015038 UDP-glucose 4-epimerase; Region: PLN02240 405531015039 NAD binding site [chemical binding]; other site 405531015040 homodimer interface [polypeptide binding]; other site 405531015041 active site 405531015042 substrate binding site [chemical binding]; other site 405531015043 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405531015044 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 405531015045 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 405531015046 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 405531015047 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405531015048 ATP binding site [chemical binding]; other site 405531015049 Mg++ binding site [ion binding]; other site 405531015050 motif III; other site 405531015051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531015052 nucleotide binding region [chemical binding]; other site 405531015053 ATP-binding site [chemical binding]; other site 405531015054 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 405531015055 RNA binding site [nucleotide binding]; other site 405531015056 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 405531015057 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405531015058 active site 405531015059 oligoendopeptidase F; Region: pepF; TIGR00181 405531015060 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 405531015061 active site 405531015062 Zn binding site [ion binding]; other site 405531015063 Radical SAM superfamily; Region: Radical_SAM; pfam04055 405531015064 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405531015065 FeS/SAM binding site; other site 405531015066 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 405531015067 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 405531015068 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405531015069 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405531015070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531015071 PAS domain; Region: PAS_9; pfam13426 405531015072 putative active site [active] 405531015073 heme pocket [chemical binding]; other site 405531015074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531015075 dimer interface [polypeptide binding]; other site 405531015076 phosphorylation site [posttranslational modification] 405531015077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531015078 ATP binding site [chemical binding]; other site 405531015079 Mg2+ binding site [ion binding]; other site 405531015080 G-X-G motif; other site 405531015081 DNA-sulfur modification-associated; Region: DndB; pfam14072 405531015082 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 405531015083 metal binding site [ion binding]; metal-binding site 405531015084 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405531015085 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 405531015086 catalytic residues [active] 405531015087 catalytic nucleophile [active] 405531015088 Recombinase; Region: Recombinase; pfam07508 405531015089 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 405531015090 D5 N terminal like; Region: D5_N; smart00885 405531015091 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 405531015092 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 405531015093 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405531015094 active site 405531015095 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 405531015096 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531015097 cofactor binding site; other site 405531015098 DNA binding site [nucleotide binding] 405531015099 substrate interaction site [chemical binding]; other site 405531015100 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531015101 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 405531015102 cofactor binding site; other site 405531015103 DNA binding site [nucleotide binding] 405531015104 substrate interaction site [chemical binding]; other site 405531015105 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 405531015106 CxxH/CxxC protein, BA_5709 family; Region: CxxH_BA5709; TIGR04129 405531015107 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 405531015108 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405531015109 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405531015110 protein binding site [polypeptide binding]; other site 405531015111 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 405531015112 YycH protein; Region: YycI; pfam09648 405531015113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 405531015114 YycH protein; Region: YycH; pfam07435 405531015115 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405531015116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 405531015117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405531015118 dimerization interface [polypeptide binding]; other site 405531015119 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405531015120 putative active site [active] 405531015121 heme pocket [chemical binding]; other site 405531015122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405531015123 dimer interface [polypeptide binding]; other site 405531015124 phosphorylation site [posttranslational modification] 405531015125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531015126 ATP binding site [chemical binding]; other site 405531015127 Mg2+ binding site [ion binding]; other site 405531015128 G-X-G motif; other site 405531015129 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 405531015130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531015131 active site 405531015132 phosphorylation site [posttranslational modification] 405531015133 intermolecular recognition site; other site 405531015134 dimerization interface [polypeptide binding]; other site 405531015135 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405531015136 DNA binding site [nucleotide binding] 405531015137 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 405531015138 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 405531015139 GDP-binding site [chemical binding]; other site 405531015140 ACT binding site; other site 405531015141 IMP binding site; other site 405531015142 replicative DNA helicase; Provisional; Region: PRK05748 405531015143 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405531015144 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405531015145 Walker A motif; other site 405531015146 ATP binding site [chemical binding]; other site 405531015147 Walker B motif; other site 405531015148 DNA binding loops [nucleotide binding] 405531015149 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 405531015150 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 405531015151 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 405531015152 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 405531015153 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 405531015154 DHH family; Region: DHH; pfam01368 405531015155 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 405531015156 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 405531015157 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405531015158 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405531015159 dimer interface [polypeptide binding]; other site 405531015160 ssDNA binding site [nucleotide binding]; other site 405531015161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531015162 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 405531015163 GTP-binding protein YchF; Reviewed; Region: PRK09601 405531015164 YchF GTPase; Region: YchF; cd01900 405531015165 G1 box; other site 405531015166 GTP/Mg2+ binding site [chemical binding]; other site 405531015167 Switch I region; other site 405531015168 G2 box; other site 405531015169 Switch II region; other site 405531015170 G3 box; other site 405531015171 G4 box; other site 405531015172 G5 box; other site 405531015173 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 405531015174 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 405531015175 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405531015176 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405531015177 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 405531015178 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405531015179 ParB-like nuclease domain; Region: ParB; smart00470 405531015180 KorB domain; Region: KorB; pfam08535 405531015181 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 405531015182 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405531015183 P-loop; other site 405531015184 Magnesium ion binding site [ion binding]; other site 405531015185 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405531015186 Magnesium ion binding site [ion binding]; other site 405531015187 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 405531015188 ParB-like nuclease domain; Region: ParBc; pfam02195 405531015189 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 405531015190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405531015191 S-adenosylmethionine binding site [chemical binding]; other site 405531015192 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 405531015193 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 405531015194 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 405531015195 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 405531015196 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 405531015197 trmE is a tRNA modification GTPase; Region: trmE; cd04164 405531015198 G1 box; other site 405531015199 GTP/Mg2+ binding site [chemical binding]; other site 405531015200 Switch I region; other site 405531015201 G2 box; other site 405531015202 Switch II region; other site 405531015203 G3 box; other site 405531015204 G4 box; other site 405531015205 G5 box; other site 405531015206 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 405531015207 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 405531015208 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 405531015209 G-X-X-G motif; other site 405531015210 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 405531015211 RxxxH motif; other site 405531015212 OxaA-like protein precursor; Validated; Region: PRK02944 405531015213 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 405531015214 ribonuclease P; Reviewed; Region: rnpA; PRK00499 405531015215 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 405531015216 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 405531015217 DNA binding residues [nucleotide binding] 405531015218 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531015219 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 405531015220 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 405531015221 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405531015222 nucleotide binding region [chemical binding]; other site 405531015223 ATP-binding site [chemical binding]; other site 405531015224 HEPN domain; Region: HEPN; pfam05168 405531015225 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405531015226 active site 405531015227 NTP binding site [chemical binding]; other site 405531015228 metal binding triad [ion binding]; metal-binding site 405531015229 antibiotic binding site [chemical binding]; other site 405531015230 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405531015231 Mg binding site [ion binding]; other site 405531015232 nucleotide binding site [chemical binding]; other site 405531015233 putative protofilament interface [polypeptide binding]; other site 405531015234 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 405531015235 Bacterial Ig-like domain; Region: Big_5; pfam13205 405531015236 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405531015237 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405531015238 catalytic residue [active] 405531015239 Glycine rich protein; Region: Gly_rich; pfam12810 405531015240 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531015241 Interdomain contacts; other site 405531015242 Cytokine receptor motif; other site 405531015243 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 405531015244 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531015245 Interdomain contacts; other site 405531015246 Cytokine receptor motif; other site 405531015247 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 405531015248 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405531015249 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 405531015250 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405531015251 Interdomain contacts; other site 405531015252 Cytokine receptor motif; other site 405531015253 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 405531015254 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 405531015255 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 405531015256 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 405531015257 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 405531015258 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 405531015259 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405531015260 Walker A motif; other site 405531015261 ATP binding site [chemical binding]; other site 405531015262 Walker B motif; other site 405531015263 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 405531015264 active site 405531015265 catalytic residues [active] 405531015266 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 405531015267 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 405531015268 Domain of unknown function (DUF370); Region: DUF370; cl00898 405531015269 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405531015270 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 405531015271 active site 405531015272 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 405531015273 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 405531015274 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 405531015275 active site 405531015276 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405531015277 amidase catalytic site [active] 405531015278 Zn binding residues [ion binding]; other site 405531015279 substrate binding site [chemical binding]; other site 405531015280 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 405531015281 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405531015282 Helix-turn-helix domain; Region: HTH_36; pfam13730 405531015283 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405531015284 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405531015285 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 405531015286 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 405531015287 DNA binding residues [nucleotide binding] 405531015288 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 405531015289 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405531015290 generic binding surface II; other site 405531015291 generic binding surface I; other site 405531015292 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405531015293 active site 405531015294 metal binding site [ion binding]; metal-binding site 405531015295 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405531015296 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405531015297 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 405531015298 S-layer homology domain; Region: SLH; pfam00395 405531015299 S-layer homology domain; Region: SLH; pfam00395 405531015300 S-layer homology domain; Region: SLH; pfam00395 405531015301 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 405531015302 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405531015303 RNA binding site [nucleotide binding]; other site 405531015304 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405531015305 dimer interface [polypeptide binding]; other site 405531015306 ssDNA binding site [nucleotide binding]; other site 405531015307 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405531015308 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 405531015309 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405531015310 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 405531015311 helicase superfamily c-terminal domain; Region: HELICc; smart00490 405531015312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405531015313 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 405531015314 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405531015315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405531015316 ATP binding site [chemical binding]; other site 405531015317 Mg2+ binding site [ion binding]; other site 405531015318 G-X-G motif; other site 405531015319 transcriptional regulator NarL; Provisional; Region: PRK10651 405531015320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405531015321 active site 405531015322 phosphorylation site [posttranslational modification] 405531015323 intermolecular recognition site; other site 405531015324 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 405531015325 DNA binding residues [nucleotide binding] 405531015326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531015327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405531015328 non-specific DNA binding site [nucleotide binding]; other site 405531015329 salt bridge; other site 405531015330 sequence-specific DNA binding site [nucleotide binding]; other site 405531015331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405531015332 non-specific DNA binding site [nucleotide binding]; other site 405531015333 salt bridge; other site 405531015334 sequence-specific DNA binding site [nucleotide binding]; other site 405531015335 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 405531015336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531015337 Walker A motif; other site 405531015338 ATP binding site [chemical binding]; other site 405531015339 Walker B motif; other site 405531015340 arginine finger; other site 405531015341 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 405531015342 Protein of unknown function (DUF4257); Region: DUF4257; pfam14074 405531015343 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 405531015344 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405531015345 Active Sites [active] 405531015346 putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183 405531015347 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531015348 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531015349 Catalytic site [active] 405531015350 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 405531015351 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 405531015352 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405531015353 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531015354 Catalytic site [active] 405531015355 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405531015356 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 405531015357 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405531015358 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405531015359 DNA binding residues [nucleotide binding] 405531015360 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 405531015361 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 405531015362 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 405531015363 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405531015364 Sm and related proteins; Region: Sm_like; cl00259 405531015365 heptamer interface [polypeptide binding]; other site 405531015366 Sm1 motif; other site 405531015367 hexamer interface [polypeptide binding]; other site 405531015368 RNA binding site [nucleotide binding]; other site 405531015369 Sm2 motif; other site 405531015370 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 405531015371 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 405531015372 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531015373 dimerization interface [polypeptide binding]; other site 405531015374 putative DNA binding site [nucleotide binding]; other site 405531015375 putative Zn2+ binding site [ion binding]; other site 405531015376 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405531015377 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405531015378 active site 405531015379 catalytic residues [active] 405531015380 DNA binding site [nucleotide binding] 405531015381 Int/Topo IB signature motif; other site 405531015382 SEC-C motif; Region: SEC-C; pfam02810 405531015383 Flagellin N-methylase; Region: FliB; pfam03692 405531015384 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 405531015385 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 405531015386 alanyl-tRNA synthetase; Provisional; Region: PRK01584 405531015387 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 405531015388 MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...; Region: MBD; cl00110 405531015389 DNA binding site [nucleotide binding] 405531015390 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 405531015391 Helix-turn-helix domain; Region: HTH_17; pfam12728 405531015392 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 405531015393 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 405531015394 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405531015395 IHF - DNA interface [nucleotide binding]; other site 405531015396 IHF dimer interface [polypeptide binding]; other site 405531015397 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405531015398 Bax inhibitor 1 like; Region: BaxI_1; cl17691 405531015399 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 405531015400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405531015401 active site 405531015402 motif I; other site 405531015403 motif II; other site 405531015404 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405531015405 catalytic residues [active] 405531015406 Domain of unknown function (DUF4358); Region: DUF4358; pfam14270 405531015407 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405531015408 Part of AAA domain; Region: AAA_19; pfam13245 405531015409 Family description; Region: UvrD_C_2; pfam13538 405531015410 DNA polymerase III subunit delta'; Validated; Region: PRK08058 405531015411 DNA polymerase III subunit delta'; Validated; Region: PRK08485 405531015412 Helix-turn-helix domain; Region: HTH_39; pfam14090 405531015413 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 405531015414 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531015415 cofactor binding site; other site 405531015416 DNA binding site [nucleotide binding] 405531015417 substrate interaction site [chemical binding]; other site 405531015418 Staphylococcal nuclease homologues; Region: SNc; smart00318 405531015419 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 405531015420 Catalytic site; other site 405531015421 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 405531015422 SurA N-terminal domain; Region: SurA_N_3; cl07813 405531015423 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405531015424 YopX protein; Region: YopX; pfam09643 405531015425 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 405531015426 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405531015427 cofactor binding site; other site 405531015428 DNA binding site [nucleotide binding] 405531015429 substrate interaction site [chemical binding]; other site 405531015430 tRNA pseudouridine synthase B; Provisional; Region: PRK14123 405531015431 primosomal protein DnaI; Reviewed; Region: PRK08939 405531015432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531015433 Walker A motif; other site 405531015434 ATP binding site [chemical binding]; other site 405531015435 Walker B motif; other site 405531015436 bacterial Hfq-like; Region: Hfq; cd01716 405531015437 hexamer interface [polypeptide binding]; other site 405531015438 Sm1 motif; other site 405531015439 RNA binding site [nucleotide binding]; other site 405531015440 Sm2 motif; other site 405531015441 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405531015442 dimerization interface [polypeptide binding]; other site 405531015443 putative DNA binding site [nucleotide binding]; other site 405531015444 putative Zn2+ binding site [ion binding]; other site 405531015445 Bacillus cereus group antimicrobial protein; Region: lci; pfam12197 405531015446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405531015447 Walker B; other site 405531015448 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405531015449 H-loop/switch region; other site 405531015450 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405531015451 DNA protecting protein DprA; Region: dprA; TIGR00732 405531015452 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 405531015453 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405531015454 active site 405531015455 DNA binding site [nucleotide binding] 405531015456 Int/Topo IB signature motif; other site 405531015457 YolD-like protein; Region: YolD; pfam08863 405531015458 DNA polymerase IV; Reviewed; Region: PRK03103 405531015459 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 405531015460 active site 405531015461 DNA binding site [nucleotide binding] 405531015462 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405531015463 Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451 405531015464 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 405531015465 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405531015466 active site 405531015467 catalytic residues [active] 405531015468 DNA binding site [nucleotide binding] 405531015469 Int/Topo IB signature motif; other site 405531015470 DNA topoisomerase; Region: Topoisom_bac; pfam01131 405531015471 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405531015472 domain I; other site 405531015473 DNA binding groove [nucleotide binding] 405531015474 phosphate binding site [ion binding]; other site 405531015475 domain II; other site 405531015476 domain III; other site 405531015477 nucleotide binding site [chemical binding]; other site 405531015478 catalytic site [active] 405531015479 domain IV; other site 405531015480 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405531015481 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 405531015482 Group II catalytic intron 405531015483 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 405531015484 active site 405531015485 metal binding site [ion binding]; metal-binding site 405531015486 stage V sporulation protein K; Region: spore_V_K; TIGR02881 405531015487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531015488 Walker A motif; other site 405531015489 ATP binding site [chemical binding]; other site 405531015490 Walker B motif; other site 405531015491 arginine finger; other site 405531015492 stage V sporulation protein K; Region: spore_V_K; TIGR02881 405531015493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405531015494 Walker A motif; other site 405531015495 ATP binding site [chemical binding]; other site 405531015496 Walker B motif; other site 405531015497 arginine finger; other site 405531015498 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405531015499 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405531015500 NlpC/P60 family; Region: NLPC_P60; pfam00877 405531015501 3D domain; Region: 3D; cl01439 405531015502 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405531015503 NlpC/P60 family; Region: NLPC_P60; pfam00877 405531015504 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405531015505 Peptidase family M23; Region: Peptidase_M23; pfam01551 405531015506 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 405531015507 AAA-like domain; Region: AAA_10; pfam12846 405531015508 PrgI family protein; Region: PrgI; pfam12666 405531015509 AAA domain; Region: AAA_31; pfam13614 405531015510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 405531015511 non-specific DNA binding site [nucleotide binding]; other site 405531015512 salt bridge; other site 405531015513 sequence-specific DNA binding site [nucleotide binding]; other site 405531015514 DNA polymerase III subunit beta; Validated; Region: PRK05643 405531015515 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405531015516 putative DNA binding surface [nucleotide binding]; other site 405531015517 dimer interface [polypeptide binding]; other site 405531015518 beta-clamp/clamp loader binding surface; other site 405531015519 beta-clamp/translesion DNA polymerase binding surface; other site 405531015520 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 405531015521 Prokaryotic E2 family D; Region: Prok-E2_D; cl14019 405531015522 PRTRC system protein A; Region: PRTRC_A; TIGR03735 405531015523 PRTRC system ThiF family protein; Region: PRTRC_ThiF; TIGR03736 405531015524 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 405531015525 ATP binding site [chemical binding]; other site 405531015526 substrate interface [chemical binding]; other site 405531015527 Domain of unknown function (DUF4320); Region: DUF4320; pfam14208 405531015528 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 405531015529 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405531015530 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 405531015531 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 405531015532 Walker A motif; other site 405531015533 ATP binding site [chemical binding]; other site 405531015534 Walker B motif; other site 405531015535 AAA domain; Region: AAA_31; pfam13614 405531015536 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405531015537 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 405531015538 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 405531015539 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 405531015540 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 405531015541 replicative DNA helicase; Region: DnaB; TIGR00665 405531015542 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405531015543 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405531015544 Walker A motif; other site 405531015545 ATP binding site [chemical binding]; other site 405531015546 Walker B motif; other site 405531015547 DNA binding loops [nucleotide binding] 405531015548 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 405531015549 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894