-- dump date 20140618_221306 -- class Genbank::misc_feature -- table misc_feature_note -- id note 66692000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 66692000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 66692000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000004 Walker A motif; other site 66692000005 ATP binding site [chemical binding]; other site 66692000006 Walker B motif; other site 66692000007 arginine finger; other site 66692000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 66692000009 DnaA box-binding interface [nucleotide binding]; other site 66692000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 66692000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 66692000012 putative DNA binding surface [nucleotide binding]; other site 66692000013 dimer interface [polypeptide binding]; other site 66692000014 beta-clamp/clamp loader binding surface; other site 66692000015 beta-clamp/translesion DNA polymerase binding surface; other site 66692000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 66692000017 recombination protein F; Reviewed; Region: recF; PRK00064 66692000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 66692000019 Walker A/P-loop; other site 66692000020 ATP binding site [chemical binding]; other site 66692000021 Q-loop/lid; other site 66692000022 ABC transporter signature motif; other site 66692000023 Walker B; other site 66692000024 D-loop; other site 66692000025 H-loop/switch region; other site 66692000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 66692000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692000028 ATP binding site [chemical binding]; other site 66692000029 Mg2+ binding site [ion binding]; other site 66692000030 G-X-G motif; other site 66692000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 66692000032 anchoring element; other site 66692000033 dimer interface [polypeptide binding]; other site 66692000034 ATP binding site [chemical binding]; other site 66692000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 66692000036 active site 66692000037 putative metal-binding site [ion binding]; other site 66692000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 66692000039 DNA gyrase subunit A; Validated; Region: PRK05560 66692000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 66692000041 CAP-like domain; other site 66692000042 active site 66692000043 primary dimer interface [polypeptide binding]; other site 66692000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692000050 oxidoreductase; Provisional; Region: PRK06128 66692000051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692000052 NAD(P) binding site [chemical binding]; other site 66692000053 active site 66692000054 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 66692000055 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 66692000056 active site 66692000057 YaaC-like Protein; Region: YaaC; pfam14175 66692000058 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 66692000059 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 66692000060 active site 66692000061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 66692000062 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 66692000063 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 66692000064 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 66692000065 seryl-tRNA synthetase; Provisional; Region: PRK05431 66692000066 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 66692000067 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 66692000068 dimer interface [polypeptide binding]; other site 66692000069 active site 66692000070 motif 1; other site 66692000071 motif 2; other site 66692000072 motif 3; other site 66692000073 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 66692000074 putative active site [active] 66692000075 catalytic triad [active] 66692000076 putative dimer interface [polypeptide binding]; other site 66692000077 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 66692000078 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692000079 PAS domain; Region: PAS; smart00091 66692000080 PAS domain; Region: PAS_9; pfam13426 66692000081 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 66692000082 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000083 Walker A motif; other site 66692000084 ATP binding site [chemical binding]; other site 66692000085 Walker B motif; other site 66692000086 arginine finger; other site 66692000087 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692000088 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 66692000089 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692000090 inhibitor-cofactor binding pocket; inhibition site 66692000091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692000092 catalytic residue [active] 66692000093 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 66692000094 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692000095 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 66692000096 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 66692000097 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 66692000098 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 66692000099 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 66692000100 active site 66692000101 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 66692000102 homodimer interface [polypeptide binding]; other site 66692000103 substrate-cofactor binding pocket; other site 66692000104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692000105 catalytic residue [active] 66692000106 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692000107 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 66692000108 metal binding site [ion binding]; metal-binding site 66692000109 dimer interface [polypeptide binding]; other site 66692000110 homoserine dehydrogenase; Provisional; Region: PRK06270 66692000111 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 66692000112 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 66692000113 NAD(P) binding pocket [chemical binding]; other site 66692000114 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 66692000115 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 66692000116 NAD(P) binding site [chemical binding]; other site 66692000117 catalytic residues [active] 66692000118 Bacterial PH domain; Region: bPH_4; pfam06713 66692000119 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692000120 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 66692000121 substrate binding pocket [chemical binding]; other site 66692000122 membrane-bound complex binding site; other site 66692000123 hinge residues; other site 66692000124 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 66692000125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692000126 dimer interface [polypeptide binding]; other site 66692000127 conserved gate region; other site 66692000128 putative PBP binding loops; other site 66692000129 ABC-ATPase subunit interface; other site 66692000130 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 66692000131 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 66692000132 Walker A/P-loop; other site 66692000133 ATP binding site [chemical binding]; other site 66692000134 Q-loop/lid; other site 66692000135 ABC transporter signature motif; other site 66692000136 Walker B; other site 66692000137 D-loop; other site 66692000138 H-loop/switch region; other site 66692000139 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 66692000140 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692000141 Walker A/P-loop; other site 66692000142 ATP binding site [chemical binding]; other site 66692000143 Q-loop/lid; other site 66692000144 ABC transporter signature motif; other site 66692000145 Walker B; other site 66692000146 D-loop; other site 66692000147 H-loop/switch region; other site 66692000148 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692000149 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692000150 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692000151 Walker A/P-loop; other site 66692000152 ATP binding site [chemical binding]; other site 66692000153 Q-loop/lid; other site 66692000154 ABC transporter signature motif; other site 66692000155 Walker B; other site 66692000156 D-loop; other site 66692000157 H-loop/switch region; other site 66692000158 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692000159 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692000160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692000161 dimer interface [polypeptide binding]; other site 66692000162 conserved gate region; other site 66692000163 putative PBP binding loops; other site 66692000164 ABC-ATPase subunit interface; other site 66692000165 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692000166 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692000167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692000168 dimer interface [polypeptide binding]; other site 66692000169 conserved gate region; other site 66692000170 putative PBP binding loops; other site 66692000171 ABC-ATPase subunit interface; other site 66692000172 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692000173 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 66692000174 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 66692000175 nucleoside/Zn binding site; other site 66692000176 dimer interface [polypeptide binding]; other site 66692000177 catalytic motif [active] 66692000178 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 66692000179 oligomer interface [polypeptide binding]; other site 66692000180 active site residues [active] 66692000181 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 66692000182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692000183 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 66692000184 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 66692000185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000186 Walker A motif; other site 66692000187 ATP binding site [chemical binding]; other site 66692000188 Walker B motif; other site 66692000189 arginine finger; other site 66692000190 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 66692000191 hypothetical protein; Validated; Region: PRK00153 66692000192 recombination protein RecR; Reviewed; Region: recR; PRK00076 66692000193 Helix-hairpin-helix domain; Region: HHH_8; pfam14716 66692000194 RecR protein; Region: RecR; pfam02132 66692000195 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 66692000196 putative active site [active] 66692000197 putative metal-binding site [ion binding]; other site 66692000198 tetramer interface [polypeptide binding]; other site 66692000199 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 66692000200 pro-sigmaK processing inhibitor BofA; Region: spore_BofA; TIGR02862 66692000201 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 66692000202 putative active site [active] 66692000203 metal binding site [ion binding]; metal-binding site 66692000204 GAF domain; Region: GAF_3; pfam13492 66692000205 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 66692000206 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692000207 dimer interface [polypeptide binding]; other site 66692000208 phosphorylation site [posttranslational modification] 66692000209 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692000210 ATP binding site [chemical binding]; other site 66692000211 Mg2+ binding site [ion binding]; other site 66692000212 G-X-G motif; other site 66692000213 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 66692000214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692000215 active site 66692000216 phosphorylation site [posttranslational modification] 66692000217 intermolecular recognition site; other site 66692000218 dimerization interface [polypeptide binding]; other site 66692000219 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000220 Walker A motif; other site 66692000221 ATP binding site [chemical binding]; other site 66692000222 Walker B motif; other site 66692000223 arginine finger; other site 66692000224 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 66692000225 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 66692000226 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 66692000227 NAD binding site [chemical binding]; other site 66692000228 substrate binding site [chemical binding]; other site 66692000229 catalytic Zn binding site [ion binding]; other site 66692000230 tetramer interface [polypeptide binding]; other site 66692000231 structural Zn binding site [ion binding]; other site 66692000232 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 66692000233 NAD(P) binding site [chemical binding]; other site 66692000234 catalytic residues [active] 66692000235 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 66692000236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692000237 Zn2+ binding site [ion binding]; other site 66692000238 Mg2+ binding site [ion binding]; other site 66692000239 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 66692000240 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 66692000241 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692000242 catalytic residue [active] 66692000243 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 66692000244 thymidylate kinase; Validated; Region: tmk; PRK00698 66692000245 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 66692000246 TMP-binding site; other site 66692000247 ATP-binding site [chemical binding]; other site 66692000248 Protein of unknown function (DUF970); Region: DUF970; pfam06153 66692000249 DNA polymerase III subunit delta'; Validated; Region: PRK08058 66692000250 DNA polymerase III subunit delta'; Validated; Region: PRK08485 66692000251 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 66692000252 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 66692000253 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 66692000254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692000255 S-adenosylmethionine binding site [chemical binding]; other site 66692000256 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 66692000257 GIY-YIG motif/motif A; other site 66692000258 putative active site [active] 66692000259 putative metal binding site [ion binding]; other site 66692000260 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 66692000261 putative SAM binding site [chemical binding]; other site 66692000262 putative homodimer interface [polypeptide binding]; other site 66692000263 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 66692000264 NurA domain; Region: NurA; pfam09376 66692000265 HerA helicase [Replication, recombination, and repair]; Region: COG0433 66692000266 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 66692000267 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 66692000268 active site 66692000269 HIGH motif; other site 66692000270 KMSKS motif; other site 66692000271 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 66692000272 tRNA binding surface [nucleotide binding]; other site 66692000273 anticodon binding site; other site 66692000274 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 66692000275 dimer interface [polypeptide binding]; other site 66692000276 putative tRNA-binding site [nucleotide binding]; other site 66692000277 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692000278 putative DNA binding site [nucleotide binding]; other site 66692000279 dimerization interface [polypeptide binding]; other site 66692000280 putative Zn2+ binding site [ion binding]; other site 66692000281 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 66692000282 Amb_all domain; Region: Amb_all; smart00656 66692000283 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 66692000284 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692000285 ABC transporter; Region: ABC_tran_2; pfam12848 66692000286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692000287 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 66692000288 Ligand Binding Site [chemical binding]; other site 66692000289 WG containing repeat; Region: WG_beta_rep; pfam14903 66692000290 WG containing repeat; Region: WG_beta_rep; pfam14903 66692000291 WG containing repeat; Region: WG_beta_rep; pfam14903 66692000292 WG containing repeat; Region: WG_beta_rep; pfam14903 66692000293 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 66692000294 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 66692000295 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 66692000296 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 66692000297 active site 66692000298 Domain of unknown function (DUF348); Region: DUF348; pfam03990 66692000299 Domain of unknown function (DUF348); Region: DUF348; pfam03990 66692000300 Domain of unknown function (DUF348); Region: DUF348; pfam03990 66692000301 G5 domain; Region: G5; pfam07501 66692000302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 66692000303 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 66692000304 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 66692000305 putative active site [active] 66692000306 putative metal binding site [ion binding]; other site 66692000307 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 66692000308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692000309 S-adenosylmethionine binding site [chemical binding]; other site 66692000310 sporulation peptidase YabG; Region: spore_yabG; TIGR02855 66692000311 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 66692000312 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 66692000313 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 66692000314 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 66692000315 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 66692000316 pur operon repressor; Provisional; Region: PRK09213 66692000317 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 66692000318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692000319 active site 66692000320 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 66692000321 homotrimer interaction site [polypeptide binding]; other site 66692000322 putative active site [active] 66692000323 regulatory protein SpoVG; Reviewed; Region: PRK13259 66692000324 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 66692000325 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 66692000326 Substrate binding site; other site 66692000327 Mg++ binding site; other site 66692000328 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 66692000329 active site 66692000330 substrate binding site [chemical binding]; other site 66692000331 CoA binding site [chemical binding]; other site 66692000332 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 66692000333 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 66692000334 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692000335 active site 66692000336 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 66692000337 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 66692000338 5S rRNA interface [nucleotide binding]; other site 66692000339 CTC domain interface [polypeptide binding]; other site 66692000340 L16 interface [polypeptide binding]; other site 66692000341 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 66692000342 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 66692000343 putative active site [active] 66692000344 catalytic residue [active] 66692000345 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 66692000346 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 66692000347 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 66692000348 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692000349 ATP binding site [chemical binding]; other site 66692000350 putative Mg++ binding site [ion binding]; other site 66692000351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692000352 nucleotide binding region [chemical binding]; other site 66692000353 ATP-binding site [chemical binding]; other site 66692000354 TRCF domain; Region: TRCF; pfam03461 66692000355 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 66692000356 stage V sporulation protein T; Region: spore_V_T; TIGR02851 66692000357 Yip1 domain; Region: Yip1; pfam04893 66692000358 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 66692000359 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 66692000360 active site 66692000361 homodimer interface [polypeptide binding]; other site 66692000362 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 66692000363 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 66692000364 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 66692000365 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 66692000366 putative SAM binding site [chemical binding]; other site 66692000367 putative homodimer interface [polypeptide binding]; other site 66692000368 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 66692000369 homodimer interface [polypeptide binding]; other site 66692000370 metal binding site [ion binding]; metal-binding site 66692000371 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 66692000372 homodimer interface [polypeptide binding]; other site 66692000373 active site 66692000374 putative chemical substrate binding site [chemical binding]; other site 66692000375 metal binding site [ion binding]; metal-binding site 66692000376 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692000377 RNA binding surface [nucleotide binding]; other site 66692000378 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 66692000379 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692000380 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692000381 motif II; other site 66692000382 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 66692000383 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 66692000384 dimerization interface [polypeptide binding]; other site 66692000385 ligand binding site [chemical binding]; other site 66692000386 NADP binding site [chemical binding]; other site 66692000387 catalytic site [active] 66692000388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692000389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692000390 Coenzyme A binding pocket [chemical binding]; other site 66692000391 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 66692000392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692000393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692000394 Predicted membrane protein [Function unknown]; Region: COG1238 66692000395 sporulation protein YabP; Region: spore_yabP; TIGR02892 66692000396 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 66692000397 Septum formation initiator; Region: DivIC; cl17659 66692000398 hypothetical protein; Provisional; Region: PRK08582 66692000399 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 66692000400 RNA binding site [nucleotide binding]; other site 66692000401 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 66692000402 Citrate transporter; Region: CitMHS; pfam03600 66692000403 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 66692000404 stage II sporulation protein E; Region: spore_II_E; TIGR02865 66692000405 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 66692000406 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 66692000407 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 66692000408 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 66692000409 metal ion-dependent adhesion site (MIDAS); other site 66692000410 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 66692000411 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 66692000412 active site 66692000413 ATP binding site [chemical binding]; other site 66692000414 substrate binding site [chemical binding]; other site 66692000415 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 66692000416 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 66692000417 Ligand Binding Site [chemical binding]; other site 66692000418 TilS substrate C-terminal domain; Region: TilS_C; smart00977 66692000419 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692000420 active site 66692000421 FtsH Extracellular; Region: FtsH_ext; pfam06480 66692000422 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 66692000423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000424 Walker A motif; other site 66692000425 ATP binding site [chemical binding]; other site 66692000426 Walker B motif; other site 66692000427 arginine finger; other site 66692000428 Peptidase family M41; Region: Peptidase_M41; pfam01434 66692000429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692000430 nucleotide binding site [chemical binding]; other site 66692000431 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 66692000432 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 66692000433 dimerization interface [polypeptide binding]; other site 66692000434 domain crossover interface; other site 66692000435 redox-dependent activation switch; other site 66692000436 cysteine synthase; Region: PLN02565 66692000437 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 66692000438 dimer interface [polypeptide binding]; other site 66692000439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692000440 catalytic residue [active] 66692000441 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 66692000442 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 66692000443 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 66692000444 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 66692000445 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 66692000446 glutamine binding [chemical binding]; other site 66692000447 catalytic triad [active] 66692000448 4-amino-4-deoxychorismate lyase; Provisional; Region: PRK07650 66692000449 homodimer interface [polypeptide binding]; other site 66692000450 substrate-cofactor binding pocket; other site 66692000451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692000452 catalytic residue [active] 66692000453 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 66692000454 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 66692000455 substrate binding pocket [chemical binding]; other site 66692000456 dimer interface [polypeptide binding]; other site 66692000457 inhibitor binding site; inhibition site 66692000458 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 66692000459 homooctamer interface [polypeptide binding]; other site 66692000460 active site 66692000461 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 66692000462 catalytic center binding site [active] 66692000463 ATP binding site [chemical binding]; other site 66692000464 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 66692000465 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 66692000466 FMN binding site [chemical binding]; other site 66692000467 active site 66692000468 catalytic residues [active] 66692000469 substrate binding site [chemical binding]; other site 66692000470 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 66692000471 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 66692000472 dimer interface [polypeptide binding]; other site 66692000473 putative anticodon binding site; other site 66692000474 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 66692000475 motif 1; other site 66692000476 active site 66692000477 motif 2; other site 66692000478 motif 3; other site 66692000479 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 66692000480 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 66692000481 UvrB/uvrC motif; Region: UVR; pfam02151 66692000482 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 66692000483 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 66692000484 ADP binding site [chemical binding]; other site 66692000485 phosphagen binding site; other site 66692000486 substrate specificity loop; other site 66692000487 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 66692000488 Clp amino terminal domain; Region: Clp_N; pfam02861 66692000489 Clp amino terminal domain; Region: Clp_N; pfam02861 66692000490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000491 Walker A motif; other site 66692000492 ATP binding site [chemical binding]; other site 66692000493 Walker B motif; other site 66692000494 arginine finger; other site 66692000495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692000496 Walker A motif; other site 66692000497 ATP binding site [chemical binding]; other site 66692000498 Walker B motif; other site 66692000499 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 66692000500 DNA repair protein RadA; Provisional; Region: PRK11823 66692000501 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 66692000502 Walker A motif/ATP binding site; other site 66692000503 ATP binding site [chemical binding]; other site 66692000504 Walker B motif; other site 66692000505 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 66692000506 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 66692000507 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 66692000508 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 66692000509 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 66692000510 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 66692000511 putative active site [active] 66692000512 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 66692000513 substrate binding site; other site 66692000514 dimer interface; other site 66692000515 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 66692000516 homotrimer interaction site [polypeptide binding]; other site 66692000517 zinc binding site [ion binding]; other site 66692000518 CDP-binding sites; other site 66692000519 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 66692000520 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 66692000521 active site 66692000522 HIGH motif; other site 66692000523 KMSKS motif; other site 66692000524 serine O-acetyltransferase; Region: cysE; TIGR01172 66692000525 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 66692000526 trimer interface [polypeptide binding]; other site 66692000527 active site 66692000528 substrate binding site [chemical binding]; other site 66692000529 CoA binding site [chemical binding]; other site 66692000530 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 66692000531 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 66692000532 active site 66692000533 HIGH motif; other site 66692000534 KMSKS motif; other site 66692000535 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 66692000536 tRNA binding surface [nucleotide binding]; other site 66692000537 anticodon binding site; other site 66692000538 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 66692000539 active site 66692000540 metal binding site [ion binding]; metal-binding site 66692000541 dimerization interface [polypeptide binding]; other site 66692000542 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 66692000543 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 66692000544 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 66692000545 YacP-like NYN domain; Region: NYN_YacP; pfam05991 66692000546 RNA polymerase factor sigma-70; Validated; Region: PRK08295 66692000547 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692000548 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 66692000549 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 66692000550 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 66692000551 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 66692000552 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 66692000553 putative homodimer interface [polypeptide binding]; other site 66692000554 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 66692000555 heterodimer interface [polypeptide binding]; other site 66692000556 homodimer interface [polypeptide binding]; other site 66692000557 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 66692000558 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 66692000559 23S rRNA interface [nucleotide binding]; other site 66692000560 L7/L12 interface [polypeptide binding]; other site 66692000561 putative thiostrepton binding site; other site 66692000562 L25 interface [polypeptide binding]; other site 66692000563 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 66692000564 mRNA/rRNA interface [nucleotide binding]; other site 66692000565 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 66692000566 23S rRNA interface [nucleotide binding]; other site 66692000567 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 66692000568 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 66692000569 core dimer interface [polypeptide binding]; other site 66692000570 peripheral dimer interface [polypeptide binding]; other site 66692000571 L10 interface [polypeptide binding]; other site 66692000572 L11 interface [polypeptide binding]; other site 66692000573 putative EF-Tu interaction site [polypeptide binding]; other site 66692000574 putative EF-G interaction site [polypeptide binding]; other site 66692000575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692000576 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692000577 S-adenosylmethionine binding site [chemical binding]; other site 66692000578 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 66692000579 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 66692000580 RPB12 interaction site [polypeptide binding]; other site 66692000581 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 66692000582 RPB1 interaction site [polypeptide binding]; other site 66692000583 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 66692000584 RPB10 interaction site [polypeptide binding]; other site 66692000585 RPB11 interaction site [polypeptide binding]; other site 66692000586 RPB3 interaction site [polypeptide binding]; other site 66692000587 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 66692000588 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 66692000589 beta and beta' interface [polypeptide binding]; other site 66692000590 beta' and sigma factor interface [polypeptide binding]; other site 66692000591 Zn-binding [ion binding]; other site 66692000592 active site region [active] 66692000593 catalytic site [active] 66692000594 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 66692000595 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 66692000596 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 66692000597 G-loop; other site 66692000598 DNA binding site [nucleotide binding] 66692000599 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 66692000600 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 66692000601 S17 interaction site [polypeptide binding]; other site 66692000602 S8 interaction site; other site 66692000603 16S rRNA interaction site [nucleotide binding]; other site 66692000604 streptomycin interaction site [chemical binding]; other site 66692000605 23S rRNA interaction site [nucleotide binding]; other site 66692000606 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 66692000607 30S ribosomal protein S7; Validated; Region: PRK05302 66692000608 elongation factor G; Reviewed; Region: PRK00007 66692000609 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 66692000610 G1 box; other site 66692000611 putative GEF interaction site [polypeptide binding]; other site 66692000612 GTP/Mg2+ binding site [chemical binding]; other site 66692000613 Switch I region; other site 66692000614 G2 box; other site 66692000615 G3 box; other site 66692000616 Switch II region; other site 66692000617 G4 box; other site 66692000618 G5 box; other site 66692000619 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 66692000620 Elongation Factor G, domain II; Region: EFG_II; pfam14492 66692000621 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 66692000622 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 66692000623 elongation factor Tu; Reviewed; Region: PRK00049 66692000624 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 66692000625 G1 box; other site 66692000626 GEF interaction site [polypeptide binding]; other site 66692000627 GTP/Mg2+ binding site [chemical binding]; other site 66692000628 Switch I region; other site 66692000629 G2 box; other site 66692000630 G3 box; other site 66692000631 Switch II region; other site 66692000632 G4 box; other site 66692000633 G5 box; other site 66692000634 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 66692000635 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 66692000636 Antibiotic Binding Site [chemical binding]; other site 66692000637 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 66692000638 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 66692000639 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 66692000640 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 66692000641 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 66692000642 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 66692000643 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 66692000644 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 66692000645 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 66692000646 putative translocon binding site; other site 66692000647 protein-rRNA interface [nucleotide binding]; other site 66692000648 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 66692000649 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 66692000650 G-X-X-G motif; other site 66692000651 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 66692000652 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 66692000653 23S rRNA interface [nucleotide binding]; other site 66692000654 5S rRNA interface [nucleotide binding]; other site 66692000655 putative antibiotic binding site [chemical binding]; other site 66692000656 L25 interface [polypeptide binding]; other site 66692000657 L27 interface [polypeptide binding]; other site 66692000658 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 66692000659 23S rRNA interface [nucleotide binding]; other site 66692000660 putative translocon interaction site; other site 66692000661 signal recognition particle (SRP54) interaction site; other site 66692000662 L23 interface [polypeptide binding]; other site 66692000663 trigger factor interaction site; other site 66692000664 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 66692000665 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 66692000666 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 66692000667 RNA binding site [nucleotide binding]; other site 66692000668 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 66692000669 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 66692000670 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 66692000671 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 66692000672 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 66692000673 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 66692000674 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 66692000675 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 66692000676 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 66692000677 5S rRNA interface [nucleotide binding]; other site 66692000678 L27 interface [polypeptide binding]; other site 66692000679 23S rRNA interface [nucleotide binding]; other site 66692000680 L5 interface [polypeptide binding]; other site 66692000681 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 66692000682 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 66692000683 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 66692000684 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 66692000685 23S rRNA binding site [nucleotide binding]; other site 66692000686 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 66692000687 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 66692000688 SecY translocase; Region: SecY; pfam00344 66692000689 adenylate kinase; Reviewed; Region: adk; PRK00279 66692000690 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 66692000691 AMP-binding site [chemical binding]; other site 66692000692 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 66692000693 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 66692000694 active site 66692000695 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 66692000696 rRNA binding site [nucleotide binding]; other site 66692000697 predicted 30S ribosome binding site; other site 66692000698 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 66692000699 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 66692000700 30S ribosomal protein S11; Validated; Region: PRK05309 66692000701 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 66692000702 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 66692000703 alphaNTD homodimer interface [polypeptide binding]; other site 66692000704 alphaNTD - beta interaction site [polypeptide binding]; other site 66692000705 alphaNTD - beta' interaction site [polypeptide binding]; other site 66692000706 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 66692000707 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 66692000708 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 66692000709 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 66692000710 Walker A/P-loop; other site 66692000711 ATP binding site [chemical binding]; other site 66692000712 Q-loop/lid; other site 66692000713 ABC transporter signature motif; other site 66692000714 Walker B; other site 66692000715 D-loop; other site 66692000716 H-loop/switch region; other site 66692000717 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 66692000718 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 66692000719 Walker A/P-loop; other site 66692000720 ATP binding site [chemical binding]; other site 66692000721 Q-loop/lid; other site 66692000722 ABC transporter signature motif; other site 66692000723 Walker B; other site 66692000724 D-loop; other site 66692000725 H-loop/switch region; other site 66692000726 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 66692000727 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 66692000728 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 66692000729 dimerization interface 3.5A [polypeptide binding]; other site 66692000730 active site 66692000731 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 66692000732 23S rRNA interface [nucleotide binding]; other site 66692000733 L3 interface [polypeptide binding]; other site 66692000734 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 66692000735 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692000736 non-specific DNA binding site [nucleotide binding]; other site 66692000737 salt bridge; other site 66692000738 sequence-specific DNA binding site [nucleotide binding]; other site 66692000739 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 66692000740 dinuclear metal binding motif [ion binding]; other site 66692000741 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 66692000742 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 66692000743 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 66692000744 active site 66692000745 metal binding site [ion binding]; metal-binding site 66692000746 CAT RNA binding domain; Region: CAT_RBD; smart01061 66692000747 transcriptional antiterminator BglG; Provisional; Region: PRK09772 66692000748 PRD domain; Region: PRD; pfam00874 66692000749 PRD domain; Region: PRD; pfam00874 66692000750 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692000751 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 66692000752 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692000753 active site turn [active] 66692000754 phosphorylation site [posttranslational modification] 66692000755 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 66692000756 HPr interaction site; other site 66692000757 glycerol kinase (GK) interaction site [polypeptide binding]; other site 66692000758 active site 66692000759 phosphorylation site [posttranslational modification] 66692000760 Domain of unknown function DUF59; Region: DUF59; cl00941 66692000761 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 66692000762 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 66692000763 Walker A motif; other site 66692000764 Bacterial PH domain; Region: bPH_4; pfam06713 66692000765 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 66692000766 Horizontally Transferred TransMembrane Domain; Region: HTTM; cl02773 66692000767 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 66692000768 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 66692000769 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 66692000770 polysaccharide deacetylase family sporulation protein PdaB; Region: spore_ybaN_pdaB; TIGR02764 66692000771 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 66692000772 putative catalytic site [active] 66692000773 putative metal binding site [ion binding]; other site 66692000774 putative phosphate binding site [ion binding]; other site 66692000775 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692000776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692000777 S-adenosylmethionine binding site [chemical binding]; other site 66692000778 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 66692000779 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692000780 DNA binding residues [nucleotide binding] 66692000781 dimer interface [polypeptide binding]; other site 66692000782 Phosphotransferase enzyme family; Region: APH; pfam01636 66692000783 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 66692000784 active site 66692000785 substrate binding site [chemical binding]; other site 66692000786 ATP binding site [chemical binding]; other site 66692000787 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 66692000788 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 66692000789 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 66692000790 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692000791 DNA binding residues [nucleotide binding] 66692000792 dimer interface [polypeptide binding]; other site 66692000793 Class II flagellar assembly regulator; Region: FliX; cl11677 66692000794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692000795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692000796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692000797 Coenzyme A binding pocket [chemical binding]; other site 66692000798 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 66692000799 Transcriptional regulator PadR-like family; Region: PadR; cl17335 66692000800 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 66692000801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692000802 non-specific DNA binding site [nucleotide binding]; other site 66692000803 salt bridge; other site 66692000804 sequence-specific DNA binding site [nucleotide binding]; other site 66692000805 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 66692000806 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 66692000807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 66692000808 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 66692000809 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 66692000810 putative ligand binding site [chemical binding]; other site 66692000811 putative NAD binding site [chemical binding]; other site 66692000812 catalytic site [active] 66692000813 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 66692000814 putative active site [active] 66692000815 metal binding site [ion binding]; metal-binding site 66692000816 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 66692000817 inhibitor site; inhibition site 66692000818 active site 66692000819 dimer interface [polypeptide binding]; other site 66692000820 catalytic residue [active] 66692000821 propionate catabolism operon regulatory protein PrpR; Region: propionate_PrpR; TIGR02329 66692000822 Propionate catabolism activator; Region: PrpR_N; pfam06506 66692000823 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 66692000824 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 66692000825 metal-binding site [ion binding] 66692000826 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 66692000827 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 66692000828 metal-binding site [ion binding] 66692000829 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 66692000830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692000831 motif II; other site 66692000832 Copper resistance protein D; Region: CopD; cl00563 66692000833 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 66692000834 Cu(I) binding site [ion binding]; other site 66692000835 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 66692000836 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 66692000837 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 66692000838 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 66692000839 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 66692000840 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 66692000841 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 66692000842 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 66692000843 YtkA-like; Region: YtkA; pfam13115 66692000844 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 66692000845 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692000846 Walker A/P-loop; other site 66692000847 ATP binding site [chemical binding]; other site 66692000848 Q-loop/lid; other site 66692000849 ABC transporter signature motif; other site 66692000850 Walker B; other site 66692000851 D-loop; other site 66692000852 H-loop/switch region; other site 66692000853 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692000854 Walker A/P-loop; other site 66692000855 ATP binding site [chemical binding]; other site 66692000856 Q-loop/lid; other site 66692000857 ABC transporter signature motif; other site 66692000858 Walker B; other site 66692000859 D-loop; other site 66692000860 H-loop/switch region; other site 66692000861 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 66692000862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692000863 dimer interface [polypeptide binding]; other site 66692000864 conserved gate region; other site 66692000865 putative PBP binding loops; other site 66692000866 ABC-ATPase subunit interface; other site 66692000867 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692000868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692000869 dimer interface [polypeptide binding]; other site 66692000870 conserved gate region; other site 66692000871 putative PBP binding loops; other site 66692000872 ABC-ATPase subunit interface; other site 66692000873 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692000874 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 66692000875 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692000876 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 66692000877 putative NAD(P) binding site [chemical binding]; other site 66692000878 catalytic Zn binding site [ion binding]; other site 66692000879 Isoamyl-acetate hydrolyzing esterase-like proteins. SGNH_hydrolase subfamily similar to the Saccharomyces cerevisiae IAH1. IAH1 may be the major esterase that hydrolyses isoamyl acetate in sake mash. The SGNH-family of hydrolases is a diverse family of...; Region: Isoamyl_acetate_hydrolase_like; cd01838 66692000880 catalytic triad [active] 66692000881 oxyanion hole [active] 66692000882 active site 66692000883 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692000884 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 66692000885 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 66692000886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692000887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692000888 DNA binding residues [nucleotide binding] 66692000889 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 66692000890 Putative zinc-finger; Region: zf-HC2; pfam13490 66692000891 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 66692000892 Uncharacterized conserved protein [Function unknown]; Region: COG1624 66692000893 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 66692000894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 66692000895 YbbR-like protein; Region: YbbR; pfam07949 66692000896 YbbR-like protein; Region: YbbR; pfam07949 66692000897 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 66692000898 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 66692000899 active site 66692000900 substrate binding site [chemical binding]; other site 66692000901 metal binding site [ion binding]; metal-binding site 66692000902 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 66692000903 Transposase domain (DUF772); Region: DUF772; pfam05598 66692000904 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 66692000905 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 66692000906 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 66692000907 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 66692000908 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 66692000909 glutaminase active site [active] 66692000910 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 66692000911 dimer interface [polypeptide binding]; other site 66692000912 active site 66692000913 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 66692000914 dimer interface [polypeptide binding]; other site 66692000915 active site 66692000916 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692000917 Helix-turn-helix domain; Region: HTH_18; pfam12833 66692000918 Proline dehydrogenase; Region: Pro_dh; pfam01619 66692000919 Beta-lactamase; Region: Beta-lactamase; pfam00144 66692000920 Phosphotransferase enzyme family; Region: APH; pfam01636 66692000921 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 66692000922 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692000923 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692000924 non-specific DNA binding site [nucleotide binding]; other site 66692000925 salt bridge; other site 66692000926 sequence-specific DNA binding site [nucleotide binding]; other site 66692000927 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 66692000928 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 66692000929 glycosyltransferase, MGT family; Region: MGT; TIGR01426 66692000930 active site 66692000931 TDP-binding site; other site 66692000932 acceptor substrate-binding pocket; other site 66692000933 homodimer interface [polypeptide binding]; other site 66692000934 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692000935 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692000936 Walker A/P-loop; other site 66692000937 ATP binding site [chemical binding]; other site 66692000938 Q-loop/lid; other site 66692000939 ABC transporter signature motif; other site 66692000940 Walker B; other site 66692000941 D-loop; other site 66692000942 H-loop/switch region; other site 66692000943 FtsX-like permease family; Region: FtsX; pfam02687 66692000944 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 66692000945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692000946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692000947 active site 66692000948 phosphorylation site [posttranslational modification] 66692000949 intermolecular recognition site; other site 66692000950 dimerization interface [polypeptide binding]; other site 66692000951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692000952 DNA binding site [nucleotide binding] 66692000953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692000954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692000955 ATP binding site [chemical binding]; other site 66692000956 Mg2+ binding site [ion binding]; other site 66692000957 G-X-G motif; other site 66692000958 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692000959 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692000960 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692000961 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692000962 putative substrate translocation pore; other site 66692000963 FtsX-like permease family; Region: FtsX; pfam02687 66692000964 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 66692000965 FtsX-like permease family; Region: FtsX; pfam02687 66692000966 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692000967 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692000968 Walker A/P-loop; other site 66692000969 ATP binding site [chemical binding]; other site 66692000970 Q-loop/lid; other site 66692000971 ABC transporter signature motif; other site 66692000972 Walker B; other site 66692000973 D-loop; other site 66692000974 H-loop/switch region; other site 66692000975 Predicted transcriptional regulators [Transcription]; Region: COG1725 66692000976 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692000977 DNA-binding site [nucleotide binding]; DNA binding site 66692000978 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692000979 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692000980 Walker A/P-loop; other site 66692000981 ATP binding site [chemical binding]; other site 66692000982 Q-loop/lid; other site 66692000983 ABC transporter signature motif; other site 66692000984 Walker B; other site 66692000985 D-loop; other site 66692000986 H-loop/switch region; other site 66692000987 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 66692000988 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 66692000989 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 66692000990 active site 66692000991 nucleotide binding site [chemical binding]; other site 66692000992 HIGH motif; other site 66692000993 KMSKS motif; other site 66692000994 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 66692000995 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 66692000996 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 66692000997 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 66692000998 Penicillinase repressor; Region: Penicillinase_R; pfam03965 66692000999 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 66692001000 active site 66692001001 NTP binding site [chemical binding]; other site 66692001002 metal binding triad [ion binding]; metal-binding site 66692001003 KNTase C-terminal domain; Region: KNTase_C; pfam07827 66692001004 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692001005 dimerization interface [polypeptide binding]; other site 66692001006 putative DNA binding site [nucleotide binding]; other site 66692001007 putative Zn2+ binding site [ion binding]; other site 66692001008 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 66692001009 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 66692001010 metal-binding site [ion binding] 66692001011 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 66692001012 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 66692001013 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 66692001014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 66692001015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692001016 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 66692001017 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692001018 S-adenosylmethionine binding site [chemical binding]; other site 66692001019 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 66692001020 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 66692001021 active site 66692001022 HIGH motif; other site 66692001023 dimer interface [polypeptide binding]; other site 66692001024 KMSKS motif; other site 66692001025 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 66692001026 EamA-like transporter family; Region: EamA; pfam00892 66692001027 EamA-like transporter family; Region: EamA; pfam00892 66692001028 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 66692001029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692001030 Coenzyme A binding pocket [chemical binding]; other site 66692001031 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 66692001032 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 66692001033 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 66692001034 nudix motif; other site 66692001035 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 66692001036 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 66692001037 BCCT family transporter; Region: BCCT; pfam02028 66692001038 TrkA-C domain; Region: TrkA_C; pfam02080 66692001039 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 66692001040 TrkA-N domain; Region: TrkA_N; pfam02254 66692001041 TrkA-C domain; Region: TrkA_C; pfam02080 66692001042 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692001043 TAP-like protein; Region: Abhydrolase_4; pfam08386 66692001044 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 66692001045 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 66692001046 Nucleoside recognition; Region: Gate; pfam07670 66692001047 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 66692001048 topology modulation protein; Reviewed; Region: PRK08118 66692001049 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 66692001050 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 66692001051 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 66692001052 Ferritin-like domain; Region: Ferritin; pfam00210 66692001053 ferroxidase diiron center [ion binding]; other site 66692001054 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 66692001055 Uncharacterized conserved protein [Function unknown]; Region: COG0062 66692001056 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 66692001057 putative substrate binding site [chemical binding]; other site 66692001058 putative ATP binding site [chemical binding]; other site 66692001059 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 66692001060 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 66692001061 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692001062 DNA binding site [nucleotide binding] 66692001063 domain linker motif; other site 66692001064 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692001065 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 66692001066 active site 66692001067 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 66692001068 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 66692001069 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 66692001070 putative active site [active] 66692001071 putative catalytic site [active] 66692001072 DctM-like transporters; Region: DctM; pfam06808 66692001073 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692001074 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692001075 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692001076 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692001077 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692001078 DNA binding site [nucleotide binding] 66692001079 domain linker motif; other site 66692001080 Ligand-binding domain of DNA transcription repressor for the hexuronate utilization operon from Bacillus species and its close homologs from other bacteria, all of which are a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_hexuronate_repressor_like; cd06272 66692001081 putative dimerization interface [polypeptide binding]; other site 66692001082 putative ligand binding site [chemical binding]; other site 66692001083 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 66692001084 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692001085 DNA binding residues [nucleotide binding] 66692001086 dimer interface [polypeptide binding]; other site 66692001087 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692001088 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692001089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692001090 Walker A/P-loop; other site 66692001091 ATP binding site [chemical binding]; other site 66692001092 Q-loop/lid; other site 66692001093 ABC transporter signature motif; other site 66692001094 Walker B; other site 66692001095 D-loop; other site 66692001096 H-loop/switch region; other site 66692001097 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 66692001098 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 66692001099 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692001100 putative active site [active] 66692001101 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 66692001102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 66692001103 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 66692001104 Propionate catabolism activator; Region: PrpR_N; pfam06506 66692001105 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692001106 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 66692001107 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 66692001108 putative active site [active] 66692001109 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 66692001110 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692001111 active site turn [active] 66692001112 phosphorylation site [posttranslational modification] 66692001113 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692001114 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 66692001115 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692001116 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692001117 DNA binding site [nucleotide binding] 66692001118 domain linker motif; other site 66692001119 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 66692001120 putative dimerization interface [polypeptide binding]; other site 66692001121 putative ligand binding site [chemical binding]; other site 66692001122 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 66692001123 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 66692001124 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692001125 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692001126 nucleotide binding site [chemical binding]; other site 66692001127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 66692001128 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001130 dimer interface [polypeptide binding]; other site 66692001131 conserved gate region; other site 66692001132 putative PBP binding loops; other site 66692001133 ABC-ATPase subunit interface; other site 66692001134 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001136 dimer interface [polypeptide binding]; other site 66692001137 conserved gate region; other site 66692001138 putative PBP binding loops; other site 66692001139 ABC-ATPase subunit interface; other site 66692001140 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001141 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692001142 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 66692001143 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 66692001144 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 66692001145 catalytic loop [active] 66692001146 iron binding site [ion binding]; other site 66692001147 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 66692001148 PAS domain; Region: PAS; smart00091 66692001149 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692001150 Walker A motif; other site 66692001151 ATP binding site [chemical binding]; other site 66692001152 Walker B motif; other site 66692001153 arginine finger; other site 66692001154 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692001155 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 66692001156 putative active site [active] 66692001157 metal binding site [ion binding]; metal-binding site 66692001158 Citrate transporter; Region: CitMHS; pfam03600 66692001159 glutaminase A; Region: Gln_ase; TIGR03814 66692001160 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 66692001161 active site 66692001162 NAD binding site [chemical binding]; other site 66692001163 metal binding site [ion binding]; metal-binding site 66692001164 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 66692001165 tetramerization interface [polypeptide binding]; other site 66692001166 NAD(P) binding site [chemical binding]; other site 66692001167 catalytic residues [active] 66692001168 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692001169 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692001170 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692001171 Coenzyme A binding pocket [chemical binding]; other site 66692001172 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692001173 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 66692001174 inhibitor-cofactor binding pocket; inhibition site 66692001175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692001176 catalytic residue [active] 66692001177 Ectoine synthase; Region: Ectoine_synth; pfam06339 66692001178 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001179 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 66692001180 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692001181 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692001182 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692001183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001184 dimer interface [polypeptide binding]; other site 66692001185 conserved gate region; other site 66692001186 putative PBP binding loops; other site 66692001187 ABC-ATPase subunit interface; other site 66692001188 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001190 dimer interface [polypeptide binding]; other site 66692001191 conserved gate region; other site 66692001192 putative PBP binding loops; other site 66692001193 ABC-ATPase subunit interface; other site 66692001194 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 66692001195 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692001196 Walker A/P-loop; other site 66692001197 ATP binding site [chemical binding]; other site 66692001198 Q-loop/lid; other site 66692001199 ABC transporter signature motif; other site 66692001200 Walker B; other site 66692001201 D-loop; other site 66692001202 H-loop/switch region; other site 66692001203 TOBE domain; Region: TOBE_2; pfam08402 66692001204 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 66692001205 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 66692001206 dimer interface [polypeptide binding]; other site 66692001207 acyl-activating enzyme (AAE) consensus motif; other site 66692001208 putative active site [active] 66692001209 AMP binding site [chemical binding]; other site 66692001210 putative CoA binding site [chemical binding]; other site 66692001211 acyl-CoA synthetase; Validated; Region: PRK07638 66692001212 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 66692001213 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 66692001214 acyl-activating enzyme (AAE) consensus motif; other site 66692001215 acyl-activating enzyme (AAE) consensus motif; other site 66692001216 AMP binding site [chemical binding]; other site 66692001217 active site 66692001218 CoA binding site [chemical binding]; other site 66692001219 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 66692001220 acetyl-CoA acetyltransferase; Provisional; Region: PRK06690 66692001221 dimer interface [polypeptide binding]; other site 66692001222 active site 66692001223 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 66692001224 classical (c) SDRs; Region: SDR_c; cd05233 66692001225 NAD(P) binding site [chemical binding]; other site 66692001226 active site 66692001227 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 66692001228 Helix-turn-helix domain; Region: HTH_18; pfam12833 66692001229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001230 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692001231 putative substrate translocation pore; other site 66692001232 Transcriptional regulator; Region: Rrf2; cl17282 66692001233 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692001234 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 66692001235 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 66692001236 heme-binding site [chemical binding]; other site 66692001237 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 66692001238 FAD binding pocket [chemical binding]; other site 66692001239 FAD binding motif [chemical binding]; other site 66692001240 phosphate binding motif [ion binding]; other site 66692001241 beta-alpha-beta structure motif; other site 66692001242 NAD binding pocket [chemical binding]; other site 66692001243 Heme binding pocket [chemical binding]; other site 66692001244 Lamin Tail Domain; Region: LTD; pfam00932 66692001245 Lamin Tail Domain; Region: LTD; pfam00932 66692001246 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 66692001247 catalytic site [active] 66692001248 active site 66692001249 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 66692001250 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 66692001251 active site 66692001252 catalytic site [active] 66692001253 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 66692001254 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 66692001255 Walker A/P-loop; other site 66692001256 ATP binding site [chemical binding]; other site 66692001257 Q-loop/lid; other site 66692001258 ABC transporter signature motif; other site 66692001259 Walker B; other site 66692001260 D-loop; other site 66692001261 H-loop/switch region; other site 66692001262 TOBE domain; Region: TOBE_2; pfam08402 66692001263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001264 dimer interface [polypeptide binding]; other site 66692001265 conserved gate region; other site 66692001266 putative PBP binding loops; other site 66692001267 ABC-ATPase subunit interface; other site 66692001268 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001270 dimer interface [polypeptide binding]; other site 66692001271 conserved gate region; other site 66692001272 putative PBP binding loops; other site 66692001273 ABC-ATPase subunit interface; other site 66692001274 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001275 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 66692001276 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 66692001277 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 66692001278 active site 66692001279 catalytic site [active] 66692001280 metal binding site [ion binding]; metal-binding site 66692001281 dimer interface [polypeptide binding]; other site 66692001282 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692001283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001284 putative substrate translocation pore; other site 66692001285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001286 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692001287 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 66692001288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692001289 active site 66692001290 motif I; other site 66692001291 motif II; other site 66692001292 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl18962 66692001293 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 66692001294 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 66692001295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001296 dimer interface [polypeptide binding]; other site 66692001297 conserved gate region; other site 66692001298 ABC-ATPase subunit interface; other site 66692001299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001301 dimer interface [polypeptide binding]; other site 66692001302 ABC-ATPase subunit interface; other site 66692001303 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 66692001304 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 66692001305 active site 66692001306 catalytic site [active] 66692001307 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692001308 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692001309 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692001310 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692001311 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692001312 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 66692001313 TM-ABC transporter signature motif; other site 66692001314 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 66692001315 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 66692001316 putative NAD(P) binding site [chemical binding]; other site 66692001317 putative active site [active] 66692001318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001319 Helix-turn-helix domain; Region: HTH_18; pfam12833 66692001320 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 66692001321 active site 66692001322 metal binding site [ion binding]; metal-binding site 66692001323 Agmatinase-like family; Region: Agmatinase-like; cd09990 66692001324 active site 66692001325 oligomer interface [polypeptide binding]; other site 66692001326 Mn binding site [ion binding]; other site 66692001327 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 66692001328 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 66692001329 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692001330 Helix-turn-helix domain; Region: HTH_18; pfam12833 66692001331 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 66692001332 N- and C-terminal domain interface [polypeptide binding]; other site 66692001333 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 66692001334 active site 66692001335 putative catalytic site [active] 66692001336 metal binding site [ion binding]; metal-binding site 66692001337 ATP binding site [chemical binding]; other site 66692001338 carbohydrate binding site [chemical binding]; other site 66692001339 L-rhamnose isomerase; Provisional; Region: PRK01076 66692001340 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase; Region: RhaD_aldol-ADH; TIGR02632 66692001341 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 66692001342 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 66692001343 putative NAD(P) binding site [chemical binding]; other site 66692001344 active site 66692001345 Domain of unknown function (DUF718); Region: DUF718; cl01281 66692001346 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 66692001347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001348 putative substrate translocation pore; other site 66692001349 Cupin domain; Region: Cupin_2; cl17218 66692001350 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692001351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692001352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692001353 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692001354 Protein of unknown function (DUF993); Region: DUF993; pfam06187 66692001355 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692001356 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692001357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692001358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692001359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692001360 Histidine kinase; Region: His_kinase; pfam06580 66692001361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692001362 ATP binding site [chemical binding]; other site 66692001363 Mg2+ binding site [ion binding]; other site 66692001364 G-X-G motif; other site 66692001365 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 66692001366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692001367 active site 66692001368 phosphorylation site [posttranslational modification] 66692001369 intermolecular recognition site; other site 66692001370 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 66692001371 dimerization interface [polypeptide binding]; other site 66692001372 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001373 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001374 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001375 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692001376 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692001377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001378 dimer interface [polypeptide binding]; other site 66692001379 conserved gate region; other site 66692001380 putative PBP binding loops; other site 66692001381 ABC-ATPase subunit interface; other site 66692001382 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001383 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001384 dimer interface [polypeptide binding]; other site 66692001385 conserved gate region; other site 66692001386 putative PBP binding loops; other site 66692001387 ABC-ATPase subunit interface; other site 66692001388 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 66692001389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692001390 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692001391 dimerization interface [polypeptide binding]; other site 66692001392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692001393 dimer interface [polypeptide binding]; other site 66692001394 phosphorylation site [posttranslational modification] 66692001395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692001396 ATP binding site [chemical binding]; other site 66692001397 Mg2+ binding site [ion binding]; other site 66692001398 G-X-G motif; other site 66692001399 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692001400 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692001401 active site 66692001402 phosphorylation site [posttranslational modification] 66692001403 intermolecular recognition site; other site 66692001404 dimerization interface [polypeptide binding]; other site 66692001405 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692001406 DNA binding site [nucleotide binding] 66692001407 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692001408 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692001409 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692001410 dimerization interface [polypeptide binding]; other site 66692001411 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 66692001412 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 66692001413 Interdomain contacts; other site 66692001414 Cytokine receptor motif; other site 66692001415 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 66692001416 metal binding site [ion binding]; metal-binding site 66692001417 active site 66692001418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001419 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692001420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001421 putative PBP binding loops; other site 66692001422 dimer interface [polypeptide binding]; other site 66692001423 ABC-ATPase subunit interface; other site 66692001424 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001426 dimer interface [polypeptide binding]; other site 66692001427 conserved gate region; other site 66692001428 putative PBP binding loops; other site 66692001429 ABC-ATPase subunit interface; other site 66692001430 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 66692001431 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 66692001432 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 66692001433 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001434 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 66692001435 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001437 dimer interface [polypeptide binding]; other site 66692001438 conserved gate region; other site 66692001439 putative PBP binding loops; other site 66692001440 ABC-ATPase subunit interface; other site 66692001441 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001443 dimer interface [polypeptide binding]; other site 66692001444 conserved gate region; other site 66692001445 putative PBP binding loops; other site 66692001446 ABC-ATPase subunit interface; other site 66692001447 Protein of unknown function, DUF624; Region: DUF624; cl02369 66692001448 Predicted transcriptional regulator [Transcription]; Region: COG4189 66692001449 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692001450 putative DNA binding site [nucleotide binding]; other site 66692001451 dimerization interface [polypeptide binding]; other site 66692001452 putative Zn2+ binding site [ion binding]; other site 66692001453 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692001454 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692001455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001457 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 66692001458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692001459 active site 66692001460 motif I; other site 66692001461 motif II; other site 66692001462 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 66692001463 active site 66692001464 metal binding site [ion binding]; metal-binding site 66692001465 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 66692001466 intersubunit interface [polypeptide binding]; other site 66692001467 active site 66692001468 Zn2+ binding site [ion binding]; other site 66692001469 ribulokinase; Provisional; Region: PRK04123 66692001470 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 66692001471 N- and C-terminal domain interface [polypeptide binding]; other site 66692001472 active site 66692001473 MgATP binding site [chemical binding]; other site 66692001474 catalytic site [active] 66692001475 metal binding site [ion binding]; metal-binding site 66692001476 carbohydrate binding site [chemical binding]; other site 66692001477 homodimer interface [polypeptide binding]; other site 66692001478 L-arabinose isomerase; Provisional; Region: PRK02929 66692001479 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 66692001480 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 66692001481 trimer interface [polypeptide binding]; other site 66692001482 putative substrate binding site [chemical binding]; other site 66692001483 putative metal binding site [ion binding]; other site 66692001484 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 66692001485 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 66692001486 putative ligand binding site [chemical binding]; other site 66692001487 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 66692001488 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 66692001489 Walker A/P-loop; other site 66692001490 ATP binding site [chemical binding]; other site 66692001491 Q-loop/lid; other site 66692001492 ABC transporter signature motif; other site 66692001493 Walker B; other site 66692001494 D-loop; other site 66692001495 H-loop/switch region; other site 66692001496 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 66692001497 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 66692001498 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 66692001499 dimer interface [polypeptide binding]; other site 66692001500 TM-ABC transporter signature motif; other site 66692001501 alpha-galactosidase; Provisional; Region: PRK15076 66692001502 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 66692001503 NAD binding site [chemical binding]; other site 66692001504 sugar binding site [chemical binding]; other site 66692001505 divalent metal binding site [ion binding]; other site 66692001506 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692001507 dimer interface [polypeptide binding]; other site 66692001508 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 66692001509 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 66692001510 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 66692001511 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692001512 ABC transporter signature motif; other site 66692001513 Walker B; other site 66692001514 D-loop; other site 66692001515 H-loop/switch region; other site 66692001516 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 66692001517 LytTr DNA-binding domain; Region: LytTR; smart00850 66692001518 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 66692001519 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 66692001520 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692001521 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692001522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692001524 putative substrate translocation pore; other site 66692001525 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 66692001526 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692001527 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 66692001528 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692001529 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 66692001530 tetrameric interface [polypeptide binding]; other site 66692001531 NAD binding site [chemical binding]; other site 66692001532 catalytic residues [active] 66692001533 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 66692001534 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 66692001535 substrate binding site [chemical binding]; other site 66692001536 ATP binding site [chemical binding]; other site 66692001537 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 66692001538 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 66692001539 PYR/PP interface [polypeptide binding]; other site 66692001540 dimer interface [polypeptide binding]; other site 66692001541 TPP binding site [chemical binding]; other site 66692001542 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 66692001543 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 66692001544 TPP-binding site; other site 66692001545 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692001546 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692001547 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692001548 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692001549 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692001550 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692001551 intersubunit interface [polypeptide binding]; other site 66692001552 active site 66692001553 zinc binding site [ion binding]; other site 66692001554 Na+ binding site [ion binding]; other site 66692001555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692001556 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692001557 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692001558 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 66692001559 Na binding site [ion binding]; other site 66692001560 Predicted membrane protein [Function unknown]; Region: COG2323 66692001561 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 66692001562 homodimer interface [polypeptide binding]; other site 66692001563 substrate-cofactor binding pocket; other site 66692001564 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692001565 catalytic residue [active] 66692001566 Putative zinc- or iron-chelating domain; Region: CxxCxxCC; pfam03692 66692001567 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001569 dimer interface [polypeptide binding]; other site 66692001570 conserved gate region; other site 66692001571 putative PBP binding loops; other site 66692001572 ABC-ATPase subunit interface; other site 66692001573 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692001574 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001575 dimer interface [polypeptide binding]; other site 66692001576 conserved gate region; other site 66692001577 putative PBP binding loops; other site 66692001578 ABC-ATPase subunit interface; other site 66692001579 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001580 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692001581 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692001582 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692001583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001584 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 66692001585 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692001586 putative NAD(P) binding site [chemical binding]; other site 66692001587 catalytic Zn binding site [ion binding]; other site 66692001588 structural Zn binding site [ion binding]; other site 66692001589 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692001590 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692001591 DctM-like transporters; Region: DctM; pfam06808 66692001592 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692001593 galactarate dehydratase; Region: galactar-dH20; TIGR03248 66692001594 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 66692001595 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 66692001596 altronate oxidoreductase; Provisional; Region: PRK03643 66692001597 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 66692001598 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 66692001599 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692001600 HTH domain; Region: HTH_11; pfam08279 66692001601 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692001602 PRD domain; Region: PRD; pfam00874 66692001603 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 66692001604 active site 66692001605 phosphorylation site [posttranslational modification] 66692001606 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692001607 intersubunit interface [polypeptide binding]; other site 66692001608 active site 66692001609 zinc binding site [ion binding]; other site 66692001610 Na+ binding site [ion binding]; other site 66692001611 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692001612 active site 66692001613 phosphorylation site [posttranslational modification] 66692001614 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 66692001615 active site 66692001616 P-loop; other site 66692001617 phosphorylation site [posttranslational modification] 66692001618 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 66692001619 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 66692001620 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 66692001621 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692001622 DNA-binding site [nucleotide binding]; DNA binding site 66692001623 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692001624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692001625 homodimer interface [polypeptide binding]; other site 66692001626 catalytic residue [active] 66692001627 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 66692001628 active site 66692001629 multimer interface [polypeptide binding]; other site 66692001630 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 66692001631 predicted active site [active] 66692001632 catalytic triad [active] 66692001633 PAS fold; Region: PAS; pfam00989 66692001634 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692001635 putative active site [active] 66692001636 heme pocket [chemical binding]; other site 66692001637 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692001638 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 66692001639 Walker A motif; other site 66692001640 ATP binding site [chemical binding]; other site 66692001641 Walker B motif; other site 66692001642 arginine finger; other site 66692001643 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692001644 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 66692001645 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 66692001646 Citrate transporter; Region: CitMHS; pfam03600 66692001647 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 66692001648 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692001649 dimerization interface [polypeptide binding]; other site 66692001650 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692001651 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 66692001652 dimer interface [polypeptide binding]; other site 66692001653 putative CheW interface [polypeptide binding]; other site 66692001654 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 66692001655 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 66692001656 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692001657 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_11; cd04669 66692001658 nudix motif; other site 66692001659 D-mannonate dehydratase [Carbohydrate transport and metabolism]; Region: UxuA; COG1312 66692001660 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 66692001661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 66692001662 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 66692001663 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 66692001664 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 66692001665 NAD(P) binding site [chemical binding]; other site 66692001666 catalytic residues [active] 66692001667 5-dehydro-4-deoxyglucarate dehydratase; Region: KdgD; TIGR03249 66692001668 catalytic residue [active] 66692001669 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692001670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692001671 DNA-binding site [nucleotide binding]; DNA binding site 66692001672 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 66692001673 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 66692001674 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 66692001675 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 66692001676 putative metal binding site; other site 66692001677 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692001678 binding surface 66692001679 TPR motif; other site 66692001680 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692001681 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692001682 DNA-binding site [nucleotide binding]; DNA binding site 66692001683 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 66692001684 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 66692001685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001686 putative substrate translocation pore; other site 66692001687 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 66692001688 active site 66692001689 catalytic motif [active] 66692001690 Zn binding site [ion binding]; other site 66692001691 Beta-lactamase; Region: Beta-lactamase; cl17358 66692001692 Beta-lactamase; Region: Beta-lactamase; cl17358 66692001693 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 66692001694 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 66692001695 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 66692001696 active site 66692001697 P-loop; other site 66692001698 phosphorylation site [posttranslational modification] 66692001699 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 66692001700 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 66692001701 methionine cluster; other site 66692001702 active site 66692001703 phosphorylation site [posttranslational modification] 66692001704 metal binding site [ion binding]; metal-binding site 66692001705 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 66692001706 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 66692001707 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692001708 HTH domain; Region: HTH_11; pfam08279 66692001709 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692001710 PRD domain; Region: PRD; pfam00874 66692001711 PRD domain; Region: PRD; pfam00874 66692001712 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692001713 active site 66692001714 P-loop; other site 66692001715 phosphorylation site [posttranslational modification] 66692001716 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692001717 active site 66692001718 phosphorylation site [posttranslational modification] 66692001719 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 66692001720 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 66692001721 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692001722 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 66692001723 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692001724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 66692001725 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 66692001726 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 66692001727 active site 66692001728 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 66692001729 putative trimer interface [polypeptide binding]; other site 66692001730 putative CoA binding site [chemical binding]; other site 66692001731 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 66692001732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692001733 DNA-binding site [nucleotide binding]; DNA binding site 66692001734 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 66692001735 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692001736 putative active site [active] 66692001737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692001738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692001739 dimerization interface [polypeptide binding]; other site 66692001740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692001741 dimer interface [polypeptide binding]; other site 66692001742 phosphorylation site [posttranslational modification] 66692001743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692001744 ATP binding site [chemical binding]; other site 66692001745 Mg2+ binding site [ion binding]; other site 66692001746 G-X-G motif; other site 66692001747 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 66692001748 Predicted membrane protein [Function unknown]; Region: COG3212 66692001749 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 66692001750 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 66692001751 Glycerate kinase family; Region: Gly_kinase; cl00841 66692001752 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 66692001753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692001754 FeS/SAM binding site; other site 66692001755 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 66692001756 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 66692001757 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692001758 FeS/SAM binding site; other site 66692001759 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692001760 S-adenosylmethionine binding site [chemical binding]; other site 66692001761 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 66692001762 homodimer interaction site [polypeptide binding]; other site 66692001763 cofactor binding site; other site 66692001764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001765 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692001766 putative substrate translocation pore; other site 66692001767 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 66692001768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692001769 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 66692001770 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 66692001771 NAD binding site [chemical binding]; other site 66692001772 substrate binding site [chemical binding]; other site 66692001773 homodimer interface [polypeptide binding]; other site 66692001774 active site 66692001775 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692001776 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 66692001777 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692001778 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 66692001779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692001780 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 66692001781 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692001782 active site 66692001783 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 66692001784 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 66692001785 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 66692001786 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 66692001787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692001788 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 66692001789 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692001790 active site 66692001791 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 66692001792 Uncharacterized protein family (UPF0262); Region: UPF0262; cl11489 66692001793 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 66692001794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692001795 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 66692001796 Walker A motif; other site 66692001797 ATP binding site [chemical binding]; other site 66692001798 Walker B motif; other site 66692001799 arginine finger; other site 66692001800 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 66692001801 active site 66692001802 catalytic triad [active] 66692001803 oxyanion hole [active] 66692001804 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 66692001805 Transcriptional regulator [Transcription]; Region: IclR; COG1414 66692001806 Bacterial transcriptional regulator; Region: IclR; pfam01614 66692001807 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 66692001808 substrate binding site [chemical binding]; other site 66692001809 ATP binding site [chemical binding]; other site 66692001810 Entner-Doudoroff aldolase; Region: eda; TIGR01182 66692001811 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 66692001812 active site 66692001813 intersubunit interface [polypeptide binding]; other site 66692001814 catalytic residue [active] 66692001815 galactonate dehydratase; Provisional; Region: PRK14017 66692001816 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 66692001817 putative active site pocket [active] 66692001818 putative metal binding site [ion binding]; other site 66692001819 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 66692001820 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 66692001821 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 66692001822 sensor protein BasS/PmrB; Provisional; Region: PRK10755 66692001823 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692001824 dimerization interface [polypeptide binding]; other site 66692001825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692001826 dimer interface [polypeptide binding]; other site 66692001827 phosphorylation site [posttranslational modification] 66692001828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692001829 ATP binding site [chemical binding]; other site 66692001830 Mg2+ binding site [ion binding]; other site 66692001831 G-X-G motif; other site 66692001832 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692001833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692001834 active site 66692001835 phosphorylation site [posttranslational modification] 66692001836 intermolecular recognition site; other site 66692001837 dimerization interface [polypeptide binding]; other site 66692001838 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692001839 DNA binding site [nucleotide binding] 66692001840 DJ-1 family protein; Region: not_thiJ; TIGR01383 66692001841 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 66692001842 conserved cys residue [active] 66692001843 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 66692001844 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 66692001845 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692001846 Predicted integral membrane protein [Function unknown]; Region: COG5652 66692001847 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 66692001848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692001849 Coenzyme A binding pocket [chemical binding]; other site 66692001850 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 66692001851 active site 66692001852 catalytic residue [active] 66692001853 dimer interface [polypeptide binding]; other site 66692001854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692001855 ATP binding site [chemical binding]; other site 66692001856 putative Mg++ binding site [ion binding]; other site 66692001857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692001858 nucleotide binding region [chemical binding]; other site 66692001859 Helicase conserved C-terminal domain; Region: Helicase_C; cl17351 66692001860 ATP-binding site [chemical binding]; other site 66692001861 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 66692001862 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692001863 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 66692001864 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 66692001865 Na binding site [ion binding]; other site 66692001866 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 66692001867 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 66692001868 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692001869 DNA-binding site [nucleotide binding]; DNA binding site 66692001870 FCD domain; Region: FCD; pfam07729 66692001871 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 66692001872 active site 66692001873 catalytic residues [active] 66692001874 metal binding site [ion binding]; metal-binding site 66692001875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692001876 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692001877 putative substrate translocation pore; other site 66692001878 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692001879 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 66692001880 metal binding site [ion binding]; metal-binding site 66692001881 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 66692001882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001883 dimer interface [polypeptide binding]; other site 66692001884 conserved gate region; other site 66692001885 ABC-ATPase subunit interface; other site 66692001886 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 66692001887 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 66692001888 Walker A/P-loop; other site 66692001889 ATP binding site [chemical binding]; other site 66692001890 Q-loop/lid; other site 66692001891 ABC transporter signature motif; other site 66692001892 Walker B; other site 66692001893 D-loop; other site 66692001894 H-loop/switch region; other site 66692001895 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692001896 NIL domain; Region: NIL; pfam09383 66692001897 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692001898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 66692001899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001900 Helix-turn-helix domain; Region: HTH_18; pfam12833 66692001901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692001902 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 66692001903 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 66692001904 inhibitor binding site; inhibition site 66692001905 active site 66692001906 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 66692001907 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 66692001908 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 66692001909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001910 dimer interface [polypeptide binding]; other site 66692001911 conserved gate region; other site 66692001912 putative PBP binding loops; other site 66692001913 ABC-ATPase subunit interface; other site 66692001914 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692001915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001916 dimer interface [polypeptide binding]; other site 66692001917 ABC-ATPase subunit interface; other site 66692001918 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692001919 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692001920 Protein of unknown function, DUF624; Region: DUF624; pfam04854 66692001921 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 66692001922 dimer interface [polypeptide binding]; other site 66692001923 active site 66692001924 metal binding site [ion binding]; metal-binding site 66692001925 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 66692001926 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 66692001927 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 66692001928 active site 66692001929 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692001930 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 66692001931 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692001932 active site 66692001933 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692001934 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 66692001935 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692001936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001937 dimer interface [polypeptide binding]; other site 66692001938 conserved gate region; other site 66692001939 putative PBP binding loops; other site 66692001940 ABC-ATPase subunit interface; other site 66692001941 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692001942 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692001943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692001944 dimer interface [polypeptide binding]; other site 66692001945 conserved gate region; other site 66692001946 putative PBP binding loops; other site 66692001947 ABC-ATPase subunit interface; other site 66692001948 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692001949 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692001950 Walker A/P-loop; other site 66692001951 ATP binding site [chemical binding]; other site 66692001952 Q-loop/lid; other site 66692001953 ABC transporter signature motif; other site 66692001954 Walker B; other site 66692001955 D-loop; other site 66692001956 H-loop/switch region; other site 66692001957 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692001958 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 66692001959 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692001960 Walker A/P-loop; other site 66692001961 ATP binding site [chemical binding]; other site 66692001962 Q-loop/lid; other site 66692001963 ABC transporter signature motif; other site 66692001964 Walker B; other site 66692001965 D-loop; other site 66692001966 H-loop/switch region; other site 66692001967 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692001968 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 66692001969 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 66692001970 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 66692001971 metal binding site [ion binding]; metal-binding site 66692001972 dimer interface [polypeptide binding]; other site 66692001973 Transcriptional regulator [Transcription]; Region: IclR; COG1414 66692001974 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 66692001975 Bacterial transcriptional regulator; Region: IclR; pfam01614 66692001976 xylose isomerase; Provisional; Region: PRK05474 66692001977 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 66692001978 N- and C-terminal domain interface [polypeptide binding]; other site 66692001979 D-xylulose kinase; Region: XylB; TIGR01312 66692001980 active site 66692001981 MgATP binding site [chemical binding]; other site 66692001982 catalytic site [active] 66692001983 metal binding site [ion binding]; metal-binding site 66692001984 xylulose binding site [chemical binding]; other site 66692001985 homodimer interface [polypeptide binding]; other site 66692001986 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 66692001987 active site 66692001988 catalytic residues [active] 66692001989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 66692001990 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692001991 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692001992 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692001993 nucleotide binding site [chemical binding]; other site 66692001994 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 66692001995 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 66692001996 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692001997 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692001998 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692001999 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 66692002000 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692002001 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 66692002002 OPT oligopeptide transporter protein; Region: OPT; cl14607 66692002003 Protein of unknown function (DUF917); Region: DUF917; pfam06032 66692002004 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 66692002005 AroM protein; Region: AroM; pfam07302 66692002006 Thermophilic metalloprotease (M29); Region: Peptidase_M29; cl19596 66692002007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692002008 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692002009 putative substrate translocation pore; other site 66692002010 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 66692002011 active site 1 [active] 66692002012 dimer interface [polypeptide binding]; other site 66692002013 hexamer interface [polypeptide binding]; other site 66692002014 active site 2 [active] 66692002015 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 66692002016 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 66692002017 Chromate transporter; Region: Chromate_transp; pfam02417 66692002018 Domain of unknown function DUF77; Region: DUF77; pfam01910 66692002019 AMP-binding domain protein; Validated; Region: PRK08315 66692002020 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 66692002021 acyl-activating enzyme (AAE) consensus motif; other site 66692002022 putative AMP binding site [chemical binding]; other site 66692002023 putative active site [active] 66692002024 putative CoA binding site [chemical binding]; other site 66692002025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692002026 binding surface 66692002027 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692002028 TPR motif; other site 66692002029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 66692002030 MOSC domain; Region: MOSC; pfam03473 66692002031 3-alpha domain; Region: 3-alpha; pfam03475 66692002032 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 66692002033 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 66692002034 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 66692002035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692002036 substrate binding pocket [chemical binding]; other site 66692002037 membrane-bound complex binding site; other site 66692002038 hinge residues; other site 66692002039 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 66692002040 active site 66692002041 dimer interface [polypeptide binding]; other site 66692002042 non-prolyl cis peptide bond; other site 66692002043 insertion regions; other site 66692002044 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692002045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002046 dimer interface [polypeptide binding]; other site 66692002047 conserved gate region; other site 66692002048 putative PBP binding loops; other site 66692002049 ABC-ATPase subunit interface; other site 66692002050 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 66692002051 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692002052 Walker A/P-loop; other site 66692002053 ATP binding site [chemical binding]; other site 66692002054 Q-loop/lid; other site 66692002055 ABC transporter signature motif; other site 66692002056 Walker B; other site 66692002057 D-loop; other site 66692002058 H-loop/switch region; other site 66692002059 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692002060 Domain of unknown function (DUF303); Region: DUF303; pfam03629 66692002061 Transcriptional regulators [Transcription]; Region: GntR; COG1802 66692002062 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692002063 DNA-binding site [nucleotide binding]; DNA binding site 66692002064 FCD domain; Region: FCD; pfam07729 66692002065 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692002066 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692002067 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692002068 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 66692002069 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692002070 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692002071 DctM-like transporters; Region: DctM; pfam06808 66692002072 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692002073 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 66692002074 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 66692002075 Active Sites [active] 66692002076 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 66692002077 ATP-sulfurylase; Region: ATPS; cd00517 66692002078 active site 66692002079 HXXH motif; other site 66692002080 flexible loop; other site 66692002081 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 66692002082 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 66692002083 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 66692002084 ligand-binding site [chemical binding]; other site 66692002085 bifunctional uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase; Reviewed; Region: PRK07168 66692002086 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 66692002087 active site 66692002088 SAM binding site [chemical binding]; other site 66692002089 homodimer interface [polypeptide binding]; other site 66692002090 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cl03649 66692002091 active site 66692002092 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 66692002093 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 66692002094 putative active site [active] 66692002095 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 66692002096 putative active site [active] 66692002097 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 66692002098 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 66692002099 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 66692002100 Flavodoxin; Region: Flavodoxin_1; pfam00258 66692002101 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 66692002102 FAD binding pocket [chemical binding]; other site 66692002103 FAD binding motif [chemical binding]; other site 66692002104 catalytic residues [active] 66692002105 NAD binding pocket [chemical binding]; other site 66692002106 phosphate binding motif [ion binding]; other site 66692002107 beta-alpha-beta structure motif; other site 66692002108 sulfite reductase subunit beta; Provisional; Region: PRK13504 66692002109 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 66692002110 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 66692002111 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 66692002112 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 66692002113 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692002114 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692002115 Walker A/P-loop; other site 66692002116 ATP binding site [chemical binding]; other site 66692002117 Q-loop/lid; other site 66692002118 ABC transporter signature motif; other site 66692002119 Walker B; other site 66692002120 D-loop; other site 66692002121 H-loop/switch region; other site 66692002122 Predicted transcriptional regulators [Transcription]; Region: COG1725 66692002123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692002124 DNA-binding site [nucleotide binding]; DNA binding site 66692002125 PrpF protein; Region: PrpF; cl19418 66692002126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 66692002127 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 66692002128 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 66692002129 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692002130 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692002131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692002132 dimerization interface [polypeptide binding]; other site 66692002133 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 66692002134 tricarballylate dehydrogenase; Validated; Region: PRK08274 66692002135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692002136 putative oxidoreductase; Provisional; Region: PRK10083 66692002137 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 66692002138 putative NAD(P) binding site [chemical binding]; other site 66692002139 catalytic Zn binding site [ion binding]; other site 66692002140 structural Zn binding site [ion binding]; other site 66692002141 mannonate dehydratase; Provisional; Region: PRK03906 66692002142 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 66692002143 D-mannonate oxidoreductase; Provisional; Region: PRK08277 66692002144 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 66692002145 putative NAD(P) binding site [chemical binding]; other site 66692002146 active site 66692002147 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 66692002148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692002149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692002150 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 66692002151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692002152 putative substrate translocation pore; other site 66692002153 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 66692002154 NAD-dependent deacetylase; Provisional; Region: PRK00481 66692002155 Transposase IS200 like; Region: Y1_Tnp; pfam01797 66692002156 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 66692002157 active site 66692002158 P-loop; other site 66692002159 phosphorylation site [posttranslational modification] 66692002160 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 66692002161 methionine cluster; other site 66692002162 active site 66692002163 phosphorylation site [posttranslational modification] 66692002164 metal binding site [ion binding]; metal-binding site 66692002165 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 66692002166 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 66692002167 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 66692002168 NAD binding site [chemical binding]; other site 66692002169 sugar binding site [chemical binding]; other site 66692002170 divalent metal binding site [ion binding]; other site 66692002171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692002172 dimer interface [polypeptide binding]; other site 66692002173 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 66692002174 putative active site [active] 66692002175 YdjC motif; other site 66692002176 Mg binding site [ion binding]; other site 66692002177 putative homodimer interface [polypeptide binding]; other site 66692002178 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 66692002179 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692002180 DNA-binding site [nucleotide binding]; DNA binding site 66692002181 UTRA domain; Region: UTRA; pfam07702 66692002182 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 66692002183 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 66692002184 active site 66692002185 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 66692002186 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 66692002187 Interdomain contacts; other site 66692002188 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 66692002189 aromatic chitin/cellulose binding site residues [chemical binding]; other site 66692002190 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 66692002191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692002192 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692002193 putative substrate translocation pore; other site 66692002194 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 66692002195 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692002196 FeS/SAM binding site; other site 66692002197 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 66692002198 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692002199 catalytic residue [active] 66692002200 arylformamidase; Region: trp_arylform; TIGR03035 66692002201 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 66692002202 Translocon-associated protein (TRAP), alpha subunit; Region: TRAP_alpha; pfam03896 66692002203 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 66692002204 Spore germination protein; Region: Spore_permease; cl17796 66692002205 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 66692002206 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692002207 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692002208 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 66692002209 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692002210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 66692002211 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 66692002212 GntP family permease; Region: GntP_permease; pfam02447 66692002213 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692002214 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692002215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002216 dimer interface [polypeptide binding]; other site 66692002217 conserved gate region; other site 66692002218 putative PBP binding loops; other site 66692002219 ABC-ATPase subunit interface; other site 66692002220 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692002221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002222 dimer interface [polypeptide binding]; other site 66692002223 conserved gate region; other site 66692002224 putative PBP binding loops; other site 66692002225 ABC-ATPase subunit interface; other site 66692002226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692002227 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692002228 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 66692002229 Citrate transporter; Region: CitMHS; pfam03600 66692002230 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 66692002231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692002232 active site 66692002233 phosphorylation site [posttranslational modification] 66692002234 intermolecular recognition site; other site 66692002235 dimerization interface [polypeptide binding]; other site 66692002236 Transcriptional regulator; Region: CitT; pfam12431 66692002237 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 66692002238 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 66692002239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692002240 ATP binding site [chemical binding]; other site 66692002241 Mg2+ binding site [ion binding]; other site 66692002242 G-X-G motif; other site 66692002243 acetylornithine deacetylase; Validated; Region: PRK08596 66692002244 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 66692002245 metal binding site [ion binding]; metal-binding site 66692002246 Putative transcription activator [Transcription]; Region: TenA; COG0819 66692002247 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 66692002248 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 66692002249 DNA-binding site [nucleotide binding]; DNA binding site 66692002250 YhfZ C-terminal domain; Region: YhfZ_C; pfam14503 66692002251 PRD domain; Region: PRD; pfam00874 66692002252 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 66692002253 Protein of unknown function; Region: YhfT; pfam10797 66692002254 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 66692002255 active site 66692002256 substrate binding pocket [chemical binding]; other site 66692002257 homodimer interaction site [polypeptide binding]; other site 66692002258 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 66692002259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692002260 catalytic residue [active] 66692002261 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 66692002262 dimer interface [polypeptide binding]; other site 66692002263 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 66692002264 active site 66692002265 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 66692002266 substrate binding site [chemical binding]; other site 66692002267 catalytic residue [active] 66692002268 putative mutase; Provisional; Region: PRK12383 66692002269 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 66692002270 HSP70 interaction site [polypeptide binding]; other site 66692002271 Tetratricopeptide repeat; Region: TPR_16; pfam13432 66692002272 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692002273 binding surface 66692002274 TPR motif; other site 66692002275 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 66692002276 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 66692002277 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 66692002278 nucleotide binding site [chemical binding]; other site 66692002279 putative NEF/HSP70 interaction site [polypeptide binding]; other site 66692002280 SBD interface [polypeptide binding]; other site 66692002281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692002282 acetoin reductases; Region: 23BDH; TIGR02415 66692002283 NAD(P) binding site [chemical binding]; other site 66692002284 active site 66692002285 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692002286 Uncharacterized conserved protein [Function unknown]; Region: COG1284 66692002287 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692002288 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 66692002289 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 66692002290 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692002291 Walker A/P-loop; other site 66692002292 ATP binding site [chemical binding]; other site 66692002293 Q-loop/lid; other site 66692002294 ABC transporter signature motif; other site 66692002295 Walker B; other site 66692002296 D-loop; other site 66692002297 H-loop/switch region; other site 66692002298 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692002299 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692002300 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692002301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692002302 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692002303 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692002304 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692002305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002306 dimer interface [polypeptide binding]; other site 66692002307 putative PBP binding loops; other site 66692002308 ABC-ATPase subunit interface; other site 66692002309 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692002310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002311 dimer interface [polypeptide binding]; other site 66692002312 conserved gate region; other site 66692002313 putative PBP binding loops; other site 66692002314 ABC-ATPase subunit interface; other site 66692002315 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 66692002316 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 66692002317 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 66692002318 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 66692002319 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 66692002320 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 66692002321 phosphopeptide binding site; other site 66692002322 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 66692002323 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 66692002324 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 66692002325 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 66692002326 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 66692002327 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 66692002328 Proteins of 100 residues with WXG; Region: WXG100; cl02005 66692002329 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 66692002330 Bombinin; Region: Bombinin; pfam05298 66692002331 Man1-Src1p-C-terminal domain; Region: MSC; pfam09402 66692002332 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 66692002333 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 66692002334 active site 66692002335 catalytic residues [active] 66692002336 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 66692002337 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692002338 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692002339 Walker A/P-loop; other site 66692002340 ATP binding site [chemical binding]; other site 66692002341 Q-loop/lid; other site 66692002342 ABC transporter signature motif; other site 66692002343 Walker B; other site 66692002344 D-loop; other site 66692002345 H-loop/switch region; other site 66692002346 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 66692002347 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 66692002348 FtsX-like permease family; Region: FtsX; pfam02687 66692002349 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 66692002350 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 66692002351 FtsX-like permease family; Region: FtsX; pfam02687 66692002352 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692002353 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 66692002354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692002355 Coenzyme A binding pocket [chemical binding]; other site 66692002356 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 66692002357 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 66692002358 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692002359 putative active site [active] 66692002360 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 66692002361 putative active site cavity [active] 66692002362 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692002363 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 66692002364 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692002365 active site turn [active] 66692002366 phosphorylation site [posttranslational modification] 66692002367 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 66692002368 peptidase T-like protein; Region: PepT-like; TIGR01883 66692002369 metal binding site [ion binding]; metal-binding site 66692002370 dimer interface [polypeptide binding]; other site 66692002371 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 66692002372 Respiratory nitrate reductase alpha N-terminal; Region: Nitr_red_alph_N; pfam14710 66692002373 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 66692002374 [4Fe-4S] binding site [ion binding]; other site 66692002375 molybdopterin cofactor binding site [chemical binding]; other site 66692002376 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 66692002377 molybdopterin cofactor binding site; other site 66692002378 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 66692002379 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 66692002380 Respiratory nitrate reductase beta C-terminal; Region: Nitr_red_bet_C; pfam14711 66692002381 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 66692002382 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 66692002383 GAF domain; Region: GAF_2; pfam13185 66692002384 PAS domain S-box; Region: sensory_box; TIGR00229 66692002385 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692002386 Histidine kinase; Region: HisKA_3; pfam07730 66692002387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692002388 ATP binding site [chemical binding]; other site 66692002389 Mg2+ binding site [ion binding]; other site 66692002390 G-X-G motif; other site 66692002391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692002392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692002393 active site 66692002394 phosphorylation site [posttranslational modification] 66692002395 intermolecular recognition site; other site 66692002396 dimerization interface [polypeptide binding]; other site 66692002397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692002398 DNA binding residues [nucleotide binding] 66692002399 dimerization interface [polypeptide binding]; other site 66692002400 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 66692002401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692002402 putative substrate translocation pore; other site 66692002403 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692002404 PAS domain; Region: PAS_9; pfam13426 66692002405 putative active site [active] 66692002406 heme pocket [chemical binding]; other site 66692002407 YwiC-like protein; Region: YwiC; pfam14256 66692002408 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692002409 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692002410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692002411 dimerization interface [polypeptide binding]; other site 66692002412 Histidine kinase; Region: His_kinase; pfam06580 66692002413 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 66692002414 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 66692002415 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692002416 active site 66692002417 phosphorylation site [posttranslational modification] 66692002418 intermolecular recognition site; other site 66692002419 dimerization interface [polypeptide binding]; other site 66692002420 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692002421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692002422 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692002423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002424 dimer interface [polypeptide binding]; other site 66692002425 conserved gate region; other site 66692002426 ABC-ATPase subunit interface; other site 66692002427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692002428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002429 dimer interface [polypeptide binding]; other site 66692002430 conserved gate region; other site 66692002431 putative PBP binding loops; other site 66692002432 ABC-ATPase subunit interface; other site 66692002433 hypothetical protein; Provisional; Region: PRK14082 66692002434 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 66692002435 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 66692002436 DNA binding residues [nucleotide binding] 66692002437 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 66692002438 alpha-galactosidase; Provisional; Region: PRK15076 66692002439 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 66692002440 NAD binding site [chemical binding]; other site 66692002441 sugar binding site [chemical binding]; other site 66692002442 divalent metal binding site [ion binding]; other site 66692002443 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692002444 dimer interface [polypeptide binding]; other site 66692002445 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692002446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692002447 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692002448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692002449 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 66692002450 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 66692002451 putative di-iron ligands [ion binding]; other site 66692002452 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692002453 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 66692002454 Histidine kinase; Region: HisKA_3; pfam07730 66692002455 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692002456 ATP binding site [chemical binding]; other site 66692002457 Mg2+ binding site [ion binding]; other site 66692002458 G-X-G motif; other site 66692002459 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692002460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692002461 active site 66692002462 phosphorylation site [posttranslational modification] 66692002463 intermolecular recognition site; other site 66692002464 dimerization interface [polypeptide binding]; other site 66692002465 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692002466 DNA binding residues [nucleotide binding] 66692002467 dimerization interface [polypeptide binding]; other site 66692002468 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 66692002469 MgtE intracellular N domain; Region: MgtE_N; pfam03448 66692002470 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 66692002471 Divalent cation transporter; Region: MgtE; pfam01769 66692002472 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692002473 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 66692002474 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 66692002475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692002476 Coenzyme A binding pocket [chemical binding]; other site 66692002477 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 66692002478 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692002479 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692002480 homodimer interface [polypeptide binding]; other site 66692002481 catalytic residue [active] 66692002482 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692002483 Coenzyme A binding pocket [chemical binding]; other site 66692002484 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 66692002485 active site 66692002486 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 66692002487 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 66692002488 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 66692002489 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 66692002490 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692002491 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 66692002492 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 66692002493 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 66692002494 active site 66692002495 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 66692002496 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 66692002497 putative NAD(P) binding site [chemical binding]; other site 66692002498 dimer interface [polypeptide binding]; other site 66692002499 histidinol-phosphatase; Provisional; Region: PRK07328 66692002500 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 66692002501 active site 66692002502 dimer interface [polypeptide binding]; other site 66692002503 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 66692002504 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 66692002505 Subtilase family; Region: Peptidase_S8; pfam00082 66692002506 catalytic triad [active] 66692002507 putative active site [active] 66692002508 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 66692002509 PA/protease domain interface [polypeptide binding]; other site 66692002510 putative integrin binding motif; other site 66692002511 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 66692002512 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 66692002513 Catalytic site [active] 66692002514 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 66692002515 Putative transcription activator [Transcription]; Region: TenA; COG0819 66692002516 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 66692002517 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 66692002518 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692002519 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 66692002520 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 66692002521 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 66692002522 HflX GTPase family; Region: HflX; cd01878 66692002523 G1 box; other site 66692002524 GTP/Mg2+ binding site [chemical binding]; other site 66692002525 Switch I region; other site 66692002526 G2 box; other site 66692002527 G3 box; other site 66692002528 Switch II region; other site 66692002529 G4 box; other site 66692002530 G5 box; other site 66692002531 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 66692002532 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 66692002533 Subtilase family; Region: Peptidase_S8; pfam00082 66692002534 active site 66692002535 catalytic residues [active] 66692002536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692002537 non-specific DNA binding site [nucleotide binding]; other site 66692002538 salt bridge; other site 66692002539 sequence-specific DNA binding site [nucleotide binding]; other site 66692002540 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 66692002541 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 66692002542 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 66692002543 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 66692002544 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 66692002545 active site residue [active] 66692002546 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 66692002547 active site residue [active] 66692002548 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 66692002549 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692002550 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 66692002551 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 66692002552 hexamer interface [polypeptide binding]; other site 66692002553 ligand binding site [chemical binding]; other site 66692002554 putative active site [active] 66692002555 NAD(P) binding site [chemical binding]; other site 66692002556 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 66692002557 Predicted permeases [General function prediction only]; Region: RarD; COG2962 66692002558 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 66692002559 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 66692002560 Walker A/P-loop; other site 66692002561 ATP binding site [chemical binding]; other site 66692002562 Q-loop/lid; other site 66692002563 ABC transporter signature motif; other site 66692002564 Walker B; other site 66692002565 D-loop; other site 66692002566 H-loop/switch region; other site 66692002567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 66692002568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692002569 substrate binding pocket [chemical binding]; other site 66692002570 membrane-bound complex binding site; other site 66692002571 hinge residues; other site 66692002572 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 66692002573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002574 dimer interface [polypeptide binding]; other site 66692002575 conserved gate region; other site 66692002576 putative PBP binding loops; other site 66692002577 ABC-ATPase subunit interface; other site 66692002578 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 66692002579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002580 dimer interface [polypeptide binding]; other site 66692002581 conserved gate region; other site 66692002582 putative PBP binding loops; other site 66692002583 ABC-ATPase subunit interface; other site 66692002584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692002585 active site 66692002586 phosphorylation site [posttranslational modification] 66692002587 intermolecular recognition site; other site 66692002588 dimerization interface [polypeptide binding]; other site 66692002589 YcbB domain; Region: YcbB; pfam08664 66692002590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692002591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692002592 ATP binding site [chemical binding]; other site 66692002593 Mg2+ binding site [ion binding]; other site 66692002594 G-X-G motif; other site 66692002595 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 66692002596 SxDxEG motif; other site 66692002597 active site 66692002598 metal binding site [ion binding]; metal-binding site 66692002599 homopentamer interface [polypeptide binding]; other site 66692002600 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692002601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002602 dimer interface [polypeptide binding]; other site 66692002603 conserved gate region; other site 66692002604 putative PBP binding loops; other site 66692002605 ABC-ATPase subunit interface; other site 66692002606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692002607 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692002608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002609 dimer interface [polypeptide binding]; other site 66692002610 conserved gate region; other site 66692002611 putative PBP binding loops; other site 66692002612 ABC-ATPase subunit interface; other site 66692002613 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692002614 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692002615 Walker A/P-loop; other site 66692002616 ATP binding site [chemical binding]; other site 66692002617 Q-loop/lid; other site 66692002618 ABC transporter signature motif; other site 66692002619 Walker B; other site 66692002620 D-loop; other site 66692002621 H-loop/switch region; other site 66692002622 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692002623 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 66692002624 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 66692002625 peptide binding site [polypeptide binding]; other site 66692002626 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 66692002627 dimer interface [polypeptide binding]; other site 66692002628 catalytic triad [active] 66692002629 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 66692002630 NlpC/P60 family; Region: NLPC_P60; pfam00877 66692002631 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 66692002632 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692002633 Walker A/P-loop; other site 66692002634 ATP binding site [chemical binding]; other site 66692002635 Q-loop/lid; other site 66692002636 ABC transporter signature motif; other site 66692002637 Walker B; other site 66692002638 D-loop; other site 66692002639 H-loop/switch region; other site 66692002640 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692002641 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 66692002642 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 66692002643 dimer interface [polypeptide binding]; other site 66692002644 FMN binding site [chemical binding]; other site 66692002645 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 66692002646 Ligand Binding Site [chemical binding]; other site 66692002647 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 66692002648 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 66692002649 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 66692002650 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 66692002651 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12573 66692002652 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 66692002653 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 66692002654 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 66692002655 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 66692002656 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 66692002657 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12586 66692002658 PRC-barrel domain; Region: PRC; pfam05239 66692002659 PRC-barrel domain; Region: PRC; pfam05239 66692002660 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692002661 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692002662 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 66692002663 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692002664 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692002665 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692002666 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692002667 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692002668 Winged helix DNA-binding domain; Region: HTH_42; pfam06224 66692002669 Predicted integral membrane protein [Function unknown]; Region: COG5578 66692002670 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 66692002671 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 66692002672 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 66692002673 Sulfatase; Region: Sulfatase; pfam00884 66692002674 Uncharacterized conserved protein [Function unknown]; Region: COG1284 66692002675 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692002676 Rhomboid family; Region: Rhomboid; pfam01694 66692002677 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 66692002678 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 66692002679 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 66692002680 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 66692002681 active site 66692002682 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 66692002683 dimer interface [polypeptide binding]; other site 66692002684 substrate binding site [chemical binding]; other site 66692002685 catalytic residues [active] 66692002686 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 66692002687 PemK-like protein; Region: PemK; pfam02452 66692002688 Rsbr N terminal; Region: Rsbr_N; pfam08678 66692002689 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 66692002690 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 66692002691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692002692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692002693 ATP binding site [chemical binding]; other site 66692002694 Mg2+ binding site [ion binding]; other site 66692002695 G-X-G motif; other site 66692002696 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 66692002697 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 66692002698 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 66692002699 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 66692002700 anti sigma factor interaction site; other site 66692002701 regulatory phosphorylation site [posttranslational modification]; other site 66692002702 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692002703 ATP binding site [chemical binding]; other site 66692002704 Mg2+ binding site [ion binding]; other site 66692002705 G-X-G motif; other site 66692002706 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 66692002707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692002708 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 66692002709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692002710 DNA binding residues [nucleotide binding] 66692002711 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 66692002712 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 66692002713 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 66692002714 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 66692002715 Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278 66692002716 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 66692002717 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 66692002718 RNA binding site [nucleotide binding]; other site 66692002719 hypothetical protein; Provisional; Region: PRK04351 66692002720 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 66692002721 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692002722 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 66692002723 DNA methylase; Region: N6_N4_Mtase; pfam01555 66692002724 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692002725 S-adenosylmethionine binding site [chemical binding]; other site 66692002726 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 66692002727 Transposase, Mutator family; Region: Transposase_mut; cl19537 66692002728 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 66692002729 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 66692002730 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 66692002731 nudix motif; other site 66692002732 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 66692002733 nucleotide binding site/active site [active] 66692002734 HIT family signature motif; other site 66692002735 catalytic residue [active] 66692002736 TraX protein; Region: TraX; cl05434 66692002737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692002738 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692002739 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 66692002740 DNA-binding site [nucleotide binding]; DNA binding site 66692002741 RNA-binding motif; other site 66692002742 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 66692002743 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692002744 dimerization interface [polypeptide binding]; other site 66692002745 putative DNA binding site [nucleotide binding]; other site 66692002746 putative Zn2+ binding site [ion binding]; other site 66692002747 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 66692002748 putative metal binding site [ion binding]; other site 66692002749 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692002750 dimerization interface [polypeptide binding]; other site 66692002751 putative DNA binding site [nucleotide binding]; other site 66692002752 putative Zn2+ binding site [ion binding]; other site 66692002753 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 66692002754 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 66692002755 transmembrane helices; other site 66692002756 Low molecular weight phosphatase family; Region: LMWPc; cd00115 66692002757 active site 66692002758 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 66692002759 Cupin; Region: Cupin_1; smart00835 66692002760 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 66692002761 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 66692002762 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 66692002763 putative metal binding site [ion binding]; other site 66692002764 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 66692002765 active site 66692002766 metal binding site [ion binding]; metal-binding site 66692002767 Transcriptional regulators [Transcription]; Region: GntR; COG1802 66692002768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692002769 DNA-binding site [nucleotide binding]; DNA binding site 66692002770 FCD domain; Region: FCD; pfam07729 66692002771 tartrate dehydrogenase; Provisional; Region: PRK08194 66692002772 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 66692002773 active site 66692002774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692002775 dimerization interface [polypeptide binding]; other site 66692002776 putative DNA binding site [nucleotide binding]; other site 66692002777 putative Zn2+ binding site [ion binding]; other site 66692002778 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692002779 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692002780 putative substrate translocation pore; other site 66692002781 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 66692002782 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 66692002783 FAD binding pocket [chemical binding]; other site 66692002784 conserved FAD binding motif [chemical binding]; other site 66692002785 phosphate binding motif [ion binding]; other site 66692002786 beta-alpha-beta structure motif; other site 66692002787 NAD binding pocket [chemical binding]; other site 66692002788 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 66692002789 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 66692002790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692002791 Walker A/P-loop; other site 66692002792 ATP binding site [chemical binding]; other site 66692002793 Q-loop/lid; other site 66692002794 ABC transporter signature motif; other site 66692002795 Walker B; other site 66692002796 D-loop; other site 66692002797 H-loop/switch region; other site 66692002798 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 66692002799 putative hydrophobic ligand binding site [chemical binding]; other site 66692002800 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692002801 dimerization interface [polypeptide binding]; other site 66692002802 putative DNA binding site [nucleotide binding]; other site 66692002803 putative Zn2+ binding site [ion binding]; other site 66692002804 Uncharacterized conserved protein [Function unknown]; Region: COG5646 66692002805 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 66692002806 AzlC protein; Region: AzlC; cl00570 66692002807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692002808 Coenzyme A binding pocket [chemical binding]; other site 66692002809 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 66692002810 dimer interface [polypeptide binding]; other site 66692002811 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 66692002812 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692002813 active site 66692002814 motif I; other site 66692002815 motif II; other site 66692002816 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692002817 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 66692002818 nudix motif; other site 66692002819 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 66692002820 homotrimer interaction site [polypeptide binding]; other site 66692002821 putative active site [active] 66692002822 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 66692002823 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 66692002824 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692002825 HTH domain; Region: HTH_11; pfam08279 66692002826 PRD domain; Region: PRD; pfam00874 66692002827 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 66692002828 active site 66692002829 phosphorylation site [posttranslational modification] 66692002830 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692002831 intersubunit interface [polypeptide binding]; other site 66692002832 active site 66692002833 zinc binding site [ion binding]; other site 66692002834 Na+ binding site [ion binding]; other site 66692002835 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 66692002836 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692002837 active site 66692002838 phosphorylation site [posttranslational modification] 66692002839 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 66692002840 active site 66692002841 P-loop; other site 66692002842 phosphorylation site [posttranslational modification] 66692002843 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 66692002844 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 66692002845 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 66692002846 MgtC family; Region: MgtC; pfam02308 66692002847 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 66692002848 CrcB-like protein; Region: CRCB; pfam02537 66692002849 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 66692002850 homodimer interface [polypeptide binding]; other site 66692002851 substrate-cofactor binding pocket; other site 66692002852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692002853 catalytic residue [active] 66692002854 thiamine monophosphate kinase; Provisional; Region: PRK05731 66692002855 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 66692002856 ATP binding site [chemical binding]; other site 66692002857 dimerization interface [polypeptide binding]; other site 66692002858 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 66692002859 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 66692002860 Glycoprotease family; Region: Peptidase_M22; pfam00814 66692002861 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 66692002862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692002863 Coenzyme A binding pocket [chemical binding]; other site 66692002864 UGMP family protein; Validated; Region: PRK09604 66692002865 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 66692002866 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 66692002867 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 66692002868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692002869 ABC transporter; Region: ABC_tran_2; pfam12848 66692002870 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692002871 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 66692002872 ABC transporter; Region: ABC_tran_2; pfam12848 66692002873 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 66692002874 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 66692002875 CoA binding domain; Region: CoA_binding; pfam02629 66692002876 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 66692002877 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 66692002878 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 66692002879 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 66692002880 Walker A/P-loop; other site 66692002881 ATP binding site [chemical binding]; other site 66692002882 Q-loop/lid; other site 66692002883 ABC transporter signature motif; other site 66692002884 Walker B; other site 66692002885 D-loop; other site 66692002886 H-loop/switch region; other site 66692002887 NIL domain; Region: NIL; pfam09383 66692002888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002889 dimer interface [polypeptide binding]; other site 66692002890 conserved gate region; other site 66692002891 putative PBP binding loops; other site 66692002892 ABC-ATPase subunit interface; other site 66692002893 NLPA lipoprotein; Region: Lipoprotein_9; cl19159 66692002894 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 66692002895 putative active site [active] 66692002896 metal binding site [ion binding]; metal-binding site 66692002897 CAAX protease self-immunity; Region: Abi; pfam02517 66692002898 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 66692002899 oligomerisation interface [polypeptide binding]; other site 66692002900 mobile loop; other site 66692002901 roof hairpin; other site 66692002902 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 66692002903 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 66692002904 ring oligomerisation interface [polypeptide binding]; other site 66692002905 ATP/Mg binding site [chemical binding]; other site 66692002906 stacking interactions; other site 66692002907 hinge regions; other site 66692002908 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692002909 HTH domain; Region: HTH_11; pfam08279 66692002910 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692002911 PRD domain; Region: PRD; pfam00874 66692002912 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692002913 active site 66692002914 P-loop; other site 66692002915 phosphorylation site [posttranslational modification] 66692002916 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 66692002917 active site 66692002918 phosphorylation site [posttranslational modification] 66692002919 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692002920 active site 66692002921 phosphorylation site [posttranslational modification] 66692002922 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 66692002923 active site 66692002924 P-loop; other site 66692002925 phosphorylation site [posttranslational modification] 66692002926 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 66692002927 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692002928 putative active site [active] 66692002929 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 66692002930 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 66692002931 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 66692002932 DNA binding site [nucleotide binding] 66692002933 catalytic residue [active] 66692002934 H2TH interface [polypeptide binding]; other site 66692002935 putative catalytic residues [active] 66692002936 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 66692002937 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 66692002938 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 66692002939 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 66692002940 trimer interface [polypeptide binding]; other site 66692002941 dimer interface [polypeptide binding]; other site 66692002942 putative active site [active] 66692002943 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 66692002944 GTP binding site; other site 66692002945 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 66692002946 MPT binding site; other site 66692002947 trimer interface [polypeptide binding]; other site 66692002948 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 66692002949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692002950 FeS/SAM binding site; other site 66692002951 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 66692002952 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 66692002953 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 66692002954 dimer interface [polypeptide binding]; other site 66692002955 putative functional site; other site 66692002956 putative MPT binding site; other site 66692002957 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 66692002958 Walker A motif; other site 66692002959 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 66692002960 MoaE homodimer interface [polypeptide binding]; other site 66692002961 MoaD interaction [polypeptide binding]; other site 66692002962 active site residues [active] 66692002963 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 66692002964 MoaE interaction surface [polypeptide binding]; other site 66692002965 MoeB interaction surface [polypeptide binding]; other site 66692002966 thiocarboxylated glycine; other site 66692002967 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 66692002968 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 66692002969 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 66692002970 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 66692002971 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692002972 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 66692002973 [4Fe-4S] binding site [ion binding]; other site 66692002974 molybdopterin cofactor binding site; other site 66692002975 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 66692002976 molybdopterin cofactor binding site; other site 66692002977 Uncharacterized conserved protein [Function unknown]; Region: COG2427 66692002978 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 66692002979 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 66692002980 dinuclear metal binding motif [ion binding]; other site 66692002981 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 66692002982 GtrA-like protein; Region: GtrA; pfam04138 66692002983 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 66692002984 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 66692002985 Ligand binding site; other site 66692002986 Putative Catalytic site; other site 66692002987 DXD motif; other site 66692002988 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 66692002989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692002990 motif II; other site 66692002991 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692002992 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 66692002993 substrate binding pocket [chemical binding]; other site 66692002994 membrane-bound complex binding site; other site 66692002995 hinge residues; other site 66692002996 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 66692002997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692002998 dimer interface [polypeptide binding]; other site 66692002999 conserved gate region; other site 66692003000 putative PBP binding loops; other site 66692003001 ABC-ATPase subunit interface; other site 66692003002 ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Region: ectoine_ehuD; TIGR03003 66692003003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003004 dimer interface [polypeptide binding]; other site 66692003005 conserved gate region; other site 66692003006 putative PBP binding loops; other site 66692003007 ABC-ATPase subunit interface; other site 66692003008 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 66692003009 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 66692003010 Walker A/P-loop; other site 66692003011 ATP binding site [chemical binding]; other site 66692003012 Q-loop/lid; other site 66692003013 ABC transporter signature motif; other site 66692003014 Walker B; other site 66692003015 D-loop; other site 66692003016 H-loop/switch region; other site 66692003017 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 66692003018 sensory histidine kinase DcuS; Provisional; Region: PRK11086 66692003019 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 66692003020 PAS domain; Region: PAS; smart00091 66692003021 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 66692003022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003023 ATP binding site [chemical binding]; other site 66692003024 Mg2+ binding site [ion binding]; other site 66692003025 G-X-G motif; other site 66692003026 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 66692003027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003028 active site 66692003029 phosphorylation site [posttranslational modification] 66692003030 intermolecular recognition site; other site 66692003031 dimerization interface [polypeptide binding]; other site 66692003032 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 66692003033 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 66692003034 Malic enzyme, N-terminal domain; Region: malic; pfam00390 66692003035 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 66692003036 putative NAD(P) binding site [chemical binding]; other site 66692003037 Domain of unknown function (DUF4429); Region: DUF4429; pfam14472 66692003038 Domain of unknown function (DUF4429); Region: DUF4429; pfam14472 66692003039 Phage-related protein [Function unknown]; Region: COG5412 66692003040 putative minor structural protein; Region: PHA01351 66692003041 Phage tail protein; Region: Sipho_tail; pfam05709 66692003042 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 66692003043 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 66692003044 Interdomain contacts; other site 66692003045 Cytokine receptor motif; other site 66692003046 gp58-like protein; Region: Gp58; pfam07902 66692003047 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 66692003048 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 66692003049 Holin family; Region: Phage_holin_4; pfam05105 66692003050 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 66692003051 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 66692003052 active site 66692003053 metal binding site [ion binding]; metal-binding site 66692003054 Sporulation related domain; Region: SPOR; pfam05036 66692003055 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 66692003056 putative FMN binding site [chemical binding]; other site 66692003057 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 66692003058 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 66692003059 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 66692003060 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 66692003061 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 66692003062 putative active site [active] 66692003063 putative metal binding site [ion binding]; other site 66692003064 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 66692003065 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 66692003066 catalytic residues [active] 66692003067 MoxR-like ATPases [General function prediction only]; Region: COG0714 66692003068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692003069 Walker A motif; other site 66692003070 ATP binding site [chemical binding]; other site 66692003071 Walker B motif; other site 66692003072 arginine finger; other site 66692003073 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 66692003074 Protein of unknown function DUF58; Region: DUF58; pfam01882 66692003075 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; cl09440 66692003076 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 66692003077 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 66692003078 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 66692003079 GMP synthase; Reviewed; Region: guaA; PRK00074 66692003080 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 66692003081 AMP/PPi binding site [chemical binding]; other site 66692003082 candidate oxyanion hole; other site 66692003083 catalytic triad [active] 66692003084 potential glutamine specificity residues [chemical binding]; other site 66692003085 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 66692003086 ATP Binding subdomain [chemical binding]; other site 66692003087 Ligand Binding sites [chemical binding]; other site 66692003088 Dimerization subdomain; other site 66692003089 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 66692003090 active site 66692003091 metal binding site [ion binding]; metal-binding site 66692003092 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692003093 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 66692003094 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692003095 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 66692003096 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 66692003097 Protein of unknown function (DUF1611); Region: DUF1611; cl19508 66692003098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692003099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692003100 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 66692003101 dimerization interface [polypeptide binding]; other site 66692003102 substrate binding pocket [chemical binding]; other site 66692003103 Erythromycin esterase; Region: Erythro_esteras; cl17110 66692003104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692003105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692003106 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692003107 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692003108 Walker A/P-loop; other site 66692003109 ATP binding site [chemical binding]; other site 66692003110 Q-loop/lid; other site 66692003111 ABC transporter signature motif; other site 66692003112 Walker B; other site 66692003113 D-loop; other site 66692003114 H-loop/switch region; other site 66692003115 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 66692003116 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 66692003117 FtsX-like permease family; Region: FtsX; pfam02687 66692003118 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692003119 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692003120 PRD domain; Region: PRD; pfam00874 66692003121 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692003122 active site 66692003123 P-loop; other site 66692003124 phosphorylation site [posttranslational modification] 66692003125 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692003126 active site 66692003127 phosphorylation site [posttranslational modification] 66692003128 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 66692003129 active site 66692003130 P-loop; other site 66692003131 phosphorylation site [posttranslational modification] 66692003132 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 66692003133 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 66692003134 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 66692003135 TPP-binding site [chemical binding]; other site 66692003136 dimer interface [polypeptide binding]; other site 66692003137 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 66692003138 PYR/PP interface [polypeptide binding]; other site 66692003139 dimer interface [polypeptide binding]; other site 66692003140 TPP binding site [chemical binding]; other site 66692003141 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692003142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692003143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692003144 putative substrate translocation pore; other site 66692003145 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692003146 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692003147 putative DNA binding site [nucleotide binding]; other site 66692003148 dimerization interface [polypeptide binding]; other site 66692003149 putative Zn2+ binding site [ion binding]; other site 66692003150 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 66692003151 Dak1 domain; Region: Dak1; cl10557 66692003152 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 66692003153 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 66692003154 active site 66692003155 active pocket/dimerization site; other site 66692003156 phosphorylation site [posttranslational modification] 66692003157 YfhD-like protein; Region: YfhD; pfam14151 66692003158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692003159 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692003160 putative substrate translocation pore; other site 66692003161 Phosphotransferase enzyme family; Region: APH; pfam01636 66692003162 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 66692003163 active site 66692003164 substrate binding site [chemical binding]; other site 66692003165 ATP binding site [chemical binding]; other site 66692003166 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 66692003167 Sulfatase; Region: Sulfatase; cl19157 66692003168 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 66692003169 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 66692003170 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 66692003171 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 66692003172 putative active site [active] 66692003173 putative metal binding site [ion binding]; other site 66692003174 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 66692003175 Proline dehydrogenase; Region: Pro_dh; pfam01619 66692003176 Uncharacterized protein family (UPF0300); Region: UPF0300; pfam08594 66692003177 PAS fold; Region: PAS_4; pfam08448 66692003178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692003179 putative active site [active] 66692003180 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 66692003181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692003182 Walker A motif; other site 66692003183 ATP binding site [chemical binding]; other site 66692003184 Walker B motif; other site 66692003185 arginine finger; other site 66692003186 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692003187 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 66692003188 aldehyde dehydrogenase family 2 member; Region: PLN02466 66692003189 Glutamate binding site [chemical binding]; other site 66692003190 homodimer interface [polypeptide binding]; other site 66692003191 NAD binding site [chemical binding]; other site 66692003192 catalytic residues [active] 66692003193 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 66692003194 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 66692003195 putative active site [active] 66692003196 putative metal binding site [ion binding]; other site 66692003197 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 66692003198 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692003199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692003200 non-specific DNA binding site [nucleotide binding]; other site 66692003201 salt bridge; other site 66692003202 sequence-specific DNA binding site [nucleotide binding]; other site 66692003203 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 66692003204 catalytic triad [active] 66692003205 conserved cis-peptide bond; other site 66692003206 heat shock protein 90; Provisional; Region: PRK05218 66692003207 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003208 ATP binding site [chemical binding]; other site 66692003209 Mg2+ binding site [ion binding]; other site 66692003210 G-X-G motif; other site 66692003211 Hsp90 protein; Region: HSP90; pfam00183 66692003212 AbgT putative transporter family; Region: ABG_transport; cl17431 66692003213 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 66692003214 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 66692003215 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 66692003216 Cysteine-rich domain; Region: CCG; pfam02754 66692003217 Cysteine-rich domain; Region: CCG; pfam02754 66692003218 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 66692003219 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 66692003220 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692003221 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 66692003222 Uncharacterized conserved protein [Function unknown]; Region: COG1556 66692003223 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692003224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692003225 DNA-binding site [nucleotide binding]; DNA binding site 66692003226 FCD domain; Region: FCD; pfam07729 66692003227 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 66692003228 active site 66692003229 NAD binding site [chemical binding]; other site 66692003230 metal binding site [ion binding]; metal-binding site 66692003231 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 66692003232 tetramerization interface [polypeptide binding]; other site 66692003233 NAD(P) binding site [chemical binding]; other site 66692003234 catalytic residues [active] 66692003235 MarR family; Region: MarR_2; cl17246 66692003236 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 66692003237 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 66692003238 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 66692003239 active site 66692003240 catalytic site [active] 66692003241 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 66692003242 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692003243 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692003244 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692003245 hypothetical protein; Provisional; Region: PRK08236 66692003246 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 66692003247 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 66692003248 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 66692003249 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692003250 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 66692003251 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692003252 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692003253 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 66692003254 NAD(P) binding site [chemical binding]; other site 66692003255 active site 66692003256 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 66692003257 glucuronate isomerase; Reviewed; Region: PRK02925 66692003258 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692003259 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 66692003260 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 66692003261 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692003262 DNA binding residues [nucleotide binding] 66692003263 dimer interface [polypeptide binding]; other site 66692003264 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 66692003265 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 66692003266 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 66692003267 malonyl-CoA binding site [chemical binding]; other site 66692003268 dimer interface [polypeptide binding]; other site 66692003269 active site 66692003270 product binding site; other site 66692003271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 66692003272 TPR repeat; Region: TPR_11; pfam13414 66692003273 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692003274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692003275 putative substrate translocation pore; other site 66692003276 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692003277 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692003278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692003279 Walker A/P-loop; other site 66692003280 ATP binding site [chemical binding]; other site 66692003281 Q-loop/lid; other site 66692003282 ABC transporter signature motif; other site 66692003283 Walker B; other site 66692003284 D-loop; other site 66692003285 H-loop/switch region; other site 66692003286 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692003287 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692003288 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 66692003289 Walker A/P-loop; other site 66692003290 ATP binding site [chemical binding]; other site 66692003291 Q-loop/lid; other site 66692003292 ABC transporter signature motif; other site 66692003293 Walker B; other site 66692003294 D-loop; other site 66692003295 H-loop/switch region; other site 66692003296 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 66692003297 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692003298 putative DNA binding site [nucleotide binding]; other site 66692003299 PLA2_like: Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids (PC or phosphatidylethanolamine), usually in a...; Region: PLA2_like; cl05417 66692003300 primary metal binding site; other site 66692003301 catalytic residues [active] 66692003302 YvrJ protein family; Region: YvrJ; pfam12841 66692003303 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 66692003304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692003305 DNA binding residues [nucleotide binding] 66692003306 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 66692003307 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 66692003308 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 66692003309 PAS domain; Region: PAS; smart00091 66692003310 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 66692003311 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003312 ATP binding site [chemical binding]; other site 66692003313 Mg2+ binding site [ion binding]; other site 66692003314 G-X-G motif; other site 66692003315 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 66692003316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003317 active site 66692003318 phosphorylation site [posttranslational modification] 66692003319 intermolecular recognition site; other site 66692003320 dimerization interface [polypeptide binding]; other site 66692003321 Transcriptional regulator; Region: CitT; pfam12431 66692003322 HTH domain; Region: HTH_11; cl17392 66692003323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 66692003324 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 66692003325 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 66692003326 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 66692003327 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 66692003328 NETI protein; Region: NETI; pfam14044 66692003329 SnoaL-like domain; Region: SnoaL_2; pfam12680 66692003330 Zinc dependent phospholipase C; Region: Zn_dep_PLPC; pfam00882 66692003331 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 66692003332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692003333 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 66692003334 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 66692003335 ATP-grasp domain; Region: ATP-grasp; pfam02222 66692003336 adenylosuccinate lyase; Provisional; Region: PRK07492 66692003337 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 66692003338 tetramer interface [polypeptide binding]; other site 66692003339 active site 66692003340 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 66692003341 ATP binding site [chemical binding]; other site 66692003342 active site 66692003343 substrate binding site [chemical binding]; other site 66692003344 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 66692003345 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 66692003346 putative active site [active] 66692003347 catalytic triad [active] 66692003348 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 66692003349 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 66692003350 dimerization interface [polypeptide binding]; other site 66692003351 ATP binding site [chemical binding]; other site 66692003352 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 66692003353 dimerization interface [polypeptide binding]; other site 66692003354 ATP binding site [chemical binding]; other site 66692003355 amidophosphoribosyltransferase; Provisional; Region: PRK07631 66692003356 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 66692003357 active site 66692003358 tetramer interface [polypeptide binding]; other site 66692003359 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692003360 active site 66692003361 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 66692003362 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 66692003363 dimerization interface [polypeptide binding]; other site 66692003364 putative ATP binding site [chemical binding]; other site 66692003365 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 66692003366 active site 66692003367 substrate binding site [chemical binding]; other site 66692003368 cosubstrate binding site; other site 66692003369 catalytic site [active] 66692003370 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 66692003371 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 66692003372 purine monophosphate binding site [chemical binding]; other site 66692003373 dimer interface [polypeptide binding]; other site 66692003374 putative catalytic residues [active] 66692003375 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 66692003376 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 66692003377 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 66692003378 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 66692003379 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 66692003380 glutamate carboxypeptidase; Reviewed; Region: PRK06133 66692003381 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 66692003382 metal binding site [ion binding]; metal-binding site 66692003383 dimer interface [polypeptide binding]; other site 66692003384 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692003385 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692003386 DNA binding site [nucleotide binding] 66692003387 domain linker motif; other site 66692003388 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 66692003389 dimerization interface [polypeptide binding]; other site 66692003390 ligand binding site [chemical binding]; other site 66692003391 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 66692003392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692003393 NAD(P) binding site [chemical binding]; other site 66692003394 active site 66692003395 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692003396 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 66692003397 inhibitor binding site; inhibition site 66692003398 catalytic Zn binding site [ion binding]; other site 66692003399 structural Zn binding site [ion binding]; other site 66692003400 NADP binding site [chemical binding]; other site 66692003401 tetramer interface [polypeptide binding]; other site 66692003402 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692003403 GntP family permease; Region: GntP_permease; pfam02447 66692003404 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 66692003405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692003406 NAD(P) binding site [chemical binding]; other site 66692003407 active site 66692003408 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692003409 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692003410 intersubunit interface [polypeptide binding]; other site 66692003411 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692003412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692003413 Coenzyme A binding pocket [chemical binding]; other site 66692003414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692003415 Conserved protein implicated in secretion [Cell motility and secretion]; Region: VPS24; COG5491 66692003416 Histidine kinase; Region: HisKA_3; pfam07730 66692003417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692003418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003419 active site 66692003420 phosphorylation site [posttranslational modification] 66692003421 intermolecular recognition site; other site 66692003422 dimerization interface [polypeptide binding]; other site 66692003423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692003424 DNA binding residues [nucleotide binding] 66692003425 dimerization interface [polypeptide binding]; other site 66692003426 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692003427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692003428 Walker A/P-loop; other site 66692003429 ATP binding site [chemical binding]; other site 66692003430 Q-loop/lid; other site 66692003431 ABC transporter signature motif; other site 66692003432 Walker B; other site 66692003433 D-loop; other site 66692003434 H-loop/switch region; other site 66692003435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692003436 ABC-2 type transporter; Region: ABC2_membrane; cl17235 66692003437 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 66692003438 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 66692003439 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 66692003440 carboxyl-terminal processing protease; Provisional; Region: PLN00049 66692003441 Uncharacterized conserved protein [Function unknown]; Region: COG5444 66692003442 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692003443 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 66692003444 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 66692003445 metal ion-dependent adhesion site (MIDAS); other site 66692003446 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 66692003447 MarR family; Region: MarR_2; cl17246 66692003448 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 66692003449 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 66692003450 Walker A/P-loop; other site 66692003451 ATP binding site [chemical binding]; other site 66692003452 Q-loop/lid; other site 66692003453 ABC transporter signature motif; other site 66692003454 Walker B; other site 66692003455 D-loop; other site 66692003456 H-loop/switch region; other site 66692003457 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 66692003458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003459 dimer interface [polypeptide binding]; other site 66692003460 conserved gate region; other site 66692003461 putative PBP binding loops; other site 66692003462 ABC-ATPase subunit interface; other site 66692003463 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 66692003464 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 66692003465 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 66692003466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692003467 FeS/SAM binding site; other site 66692003468 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 66692003469 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692003470 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692003471 active site 66692003472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 66692003473 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 66692003474 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692003475 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 66692003476 active site 66692003477 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 66692003478 active site 66692003479 catalytic residues [active] 66692003480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692003481 ABC-ATPase subunit interface; other site 66692003482 dimer interface [polypeptide binding]; other site 66692003483 putative PBP binding regions; other site 66692003484 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692003485 ABC-ATPase subunit interface; other site 66692003486 dimer interface [polypeptide binding]; other site 66692003487 putative PBP binding regions; other site 66692003488 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 66692003489 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 66692003490 Walker A/P-loop; other site 66692003491 ATP binding site [chemical binding]; other site 66692003492 Q-loop/lid; other site 66692003493 ABC transporter signature motif; other site 66692003494 Walker B; other site 66692003495 D-loop; other site 66692003496 H-loop/switch region; other site 66692003497 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 66692003498 substrate binding site [chemical binding]; other site 66692003499 putative active site [active] 66692003500 dimer interface [polypeptide binding]; other site 66692003501 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 66692003502 Part of AAA domain; Region: AAA_19; pfam13245 66692003503 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 66692003504 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 66692003505 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 66692003506 nucleotide binding pocket [chemical binding]; other site 66692003507 K-X-D-G motif; other site 66692003508 catalytic site [active] 66692003509 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 66692003510 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 66692003511 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 66692003512 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 66692003513 Dimer interface [polypeptide binding]; other site 66692003514 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 66692003515 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 66692003516 putative dimer interface [polypeptide binding]; other site 66692003517 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 66692003518 putative dimer interface [polypeptide binding]; other site 66692003519 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 66692003520 ligand binding site [chemical binding]; other site 66692003521 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 66692003522 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 66692003523 Walker A/P-loop; other site 66692003524 ATP binding site [chemical binding]; other site 66692003525 Q-loop/lid; other site 66692003526 ABC transporter signature motif; other site 66692003527 Walker B; other site 66692003528 D-loop; other site 66692003529 H-loop/switch region; other site 66692003530 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 66692003531 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 66692003532 TM-ABC transporter signature motif; other site 66692003533 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 66692003534 TM-ABC transporter signature motif; other site 66692003535 DinB family; Region: DinB; cl17821 66692003536 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 66692003537 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 66692003538 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 66692003539 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 66692003540 GatB domain; Region: GatB_Yqey; smart00845 66692003541 putative lipid kinase; Reviewed; Region: PRK13337 66692003542 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 66692003543 flavodoxin; Provisional; Region: PRK06703 66692003544 TRAM domain; Region: TRAM; cl01282 66692003545 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 66692003546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692003547 S-adenosylmethionine binding site [chemical binding]; other site 66692003548 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 66692003549 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692003550 PRD domain; Region: PRD; pfam00874 66692003551 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692003552 active site 66692003553 P-loop; other site 66692003554 phosphorylation site [posttranslational modification] 66692003555 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692003556 active site 66692003557 phosphorylation site [posttranslational modification] 66692003558 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 66692003559 active site 66692003560 P-loop; other site 66692003561 phosphorylation site [posttranslational modification] 66692003562 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 66692003563 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 66692003564 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 66692003565 TPP-binding site [chemical binding]; other site 66692003566 dimer interface [polypeptide binding]; other site 66692003567 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 66692003568 PYR/PP interface [polypeptide binding]; other site 66692003569 dimer interface [polypeptide binding]; other site 66692003570 TPP binding site [chemical binding]; other site 66692003571 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692003572 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 66692003573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692003574 NAD(P) binding site [chemical binding]; other site 66692003575 active site 66692003576 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692003577 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 66692003578 DNA binding residues [nucleotide binding] 66692003579 putative dimer interface [polypeptide binding]; other site 66692003580 GntP family permease; Region: GntP_permease; pfam02447 66692003581 gluconate transporter; Region: gntP; TIGR00791 66692003582 putative dehydratase; Provisional; Region: PRK08211 66692003583 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 66692003584 Transcriptional regulator [Transcription]; Region: IclR; COG1414 66692003585 Bacterial transcriptional regulator; Region: IclR; pfam01614 66692003586 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 66692003587 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 66692003588 inhibitor site; inhibition site 66692003589 active site 66692003590 dimer interface [polypeptide binding]; other site 66692003591 catalytic residue [active] 66692003592 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 66692003593 NAD(P) binding site [chemical binding]; other site 66692003594 catalytic residues [active] 66692003595 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 66692003596 ABC-ATPase subunit interface; other site 66692003597 dimer interface [polypeptide binding]; other site 66692003598 putative PBP binding regions; other site 66692003599 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 66692003600 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 66692003601 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 66692003602 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692003603 intersubunit interface [polypeptide binding]; other site 66692003604 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 66692003605 YodA lipocalin-like domain; Region: YodA; pfam09223 66692003606 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 66692003607 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 66692003608 P-loop, Walker A motif; other site 66692003609 Base recognition motif; other site 66692003610 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 66692003611 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692003612 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692003613 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 66692003614 active site pocket [active] 66692003615 oxyanion hole [active] 66692003616 catalytic triad [active] 66692003617 active site nucleophile [active] 66692003618 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 66692003619 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 66692003620 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692003621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003622 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692003623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003624 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692003625 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692003626 DctM-like transporters; Region: DctM; pfam06808 66692003627 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692003628 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 66692003629 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 66692003630 hypothetical protein; Validated; Region: PRK00029 66692003631 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692003632 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 66692003633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692003634 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 66692003635 putative substrate translocation pore; other site 66692003636 putative alpha-glucosidase; Provisional; Region: PRK10658 66692003637 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 66692003638 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 66692003639 active site 66692003640 homotrimer interface [polypeptide binding]; other site 66692003641 catalytic site [active] 66692003642 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 66692003643 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 66692003644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692003645 dimerization interface [polypeptide binding]; other site 66692003646 Histidine kinase; Region: His_kinase; pfam06580 66692003647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003648 ATP binding site [chemical binding]; other site 66692003649 Mg2+ binding site [ion binding]; other site 66692003650 G-X-G motif; other site 66692003651 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 66692003652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003653 active site 66692003654 phosphorylation site [posttranslational modification] 66692003655 intermolecular recognition site; other site 66692003656 dimerization interface [polypeptide binding]; other site 66692003657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003658 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692003659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003660 dimer interface [polypeptide binding]; other site 66692003661 conserved gate region; other site 66692003662 putative PBP binding loops; other site 66692003663 ABC-ATPase subunit interface; other site 66692003664 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692003665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003666 dimer interface [polypeptide binding]; other site 66692003667 conserved gate region; other site 66692003668 ABC-ATPase subunit interface; other site 66692003669 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692003670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692003671 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 66692003672 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 66692003673 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692003674 NAD(P) binding site [chemical binding]; other site 66692003675 active site 66692003676 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 66692003677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692003678 Coenzyme A binding pocket [chemical binding]; other site 66692003679 pectate lyase, PelA/Pel-15E family; Region: pec_lyase; TIGR02474 66692003680 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692003681 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692003682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003683 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692003686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003687 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692003688 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692003689 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003691 dimer interface [polypeptide binding]; other site 66692003692 conserved gate region; other site 66692003693 ABC-ATPase subunit interface; other site 66692003694 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692003695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003696 dimer interface [polypeptide binding]; other site 66692003697 conserved gate region; other site 66692003698 putative PBP binding loops; other site 66692003699 ABC-ATPase subunit interface; other site 66692003700 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 66692003701 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 66692003702 inhibitor binding site; inhibition site 66692003703 active site 66692003704 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 66692003705 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692003706 Protein of unknown function, DUF624; Region: DUF624; cl02369 66692003707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692003708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692003709 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692003710 galactarate dehydratase; Region: galactar-dH20; TIGR03248 66692003711 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 66692003712 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 66692003713 altronate oxidoreductase; Provisional; Region: PRK03643 66692003714 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 66692003715 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 66692003716 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 66692003717 MarR family; Region: MarR_2; cl17246 66692003718 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 66692003719 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 66692003720 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 66692003721 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 66692003722 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 66692003723 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 66692003724 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 66692003725 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 66692003726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692003727 NAD(P) binding site [chemical binding]; other site 66692003728 active site 66692003729 Chitin binding domain; Region: Chitin_bind_3; pfam03067 66692003730 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 66692003731 aromatic chitin/cellulose binding site residues [chemical binding]; other site 66692003732 Sporulation inhibitor A; Region: Sda; pfam08970 66692003733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 66692003734 Transposase, Mutator family; Region: Transposase_mut; cl19537 66692003735 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 66692003736 active site 66692003737 catalytic site [active] 66692003738 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003739 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003740 Domain of unknown function DUF11; Region: DUF11; pfam01345 66692003741 Domain of unknown function DUF11; Region: DUF11; pfam01345 66692003742 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003743 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003744 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003745 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003746 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003747 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003748 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003749 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003750 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003751 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003752 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003753 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 66692003754 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 66692003755 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 66692003756 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692003757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692003758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692003759 DNA binding site [nucleotide binding] 66692003760 domain linker motif; other site 66692003761 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 66692003762 putative dimerization interface [polypeptide binding]; other site 66692003763 putative ligand binding site [chemical binding]; other site 66692003764 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 66692003765 histidinol dehydrogenase; Region: hisD; TIGR00069 66692003766 NAD binding site [chemical binding]; other site 66692003767 dimerization interface [polypeptide binding]; other site 66692003768 product binding site; other site 66692003769 substrate binding site [chemical binding]; other site 66692003770 zinc binding site [ion binding]; other site 66692003771 catalytic residues [active] 66692003772 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692003773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003774 active site 66692003775 phosphorylation site [posttranslational modification] 66692003776 intermolecular recognition site; other site 66692003777 dimerization interface [polypeptide binding]; other site 66692003778 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692003779 DNA binding site [nucleotide binding] 66692003780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692003781 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692003782 dimer interface [polypeptide binding]; other site 66692003783 phosphorylation site [posttranslational modification] 66692003784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003785 ATP binding site [chemical binding]; other site 66692003786 Mg2+ binding site [ion binding]; other site 66692003787 G-X-G motif; other site 66692003788 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692003789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692003790 Walker A/P-loop; other site 66692003791 ATP binding site [chemical binding]; other site 66692003792 Q-loop/lid; other site 66692003793 ABC transporter signature motif; other site 66692003794 Walker B; other site 66692003795 D-loop; other site 66692003796 H-loop/switch region; other site 66692003797 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 66692003798 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 66692003799 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692003800 dimerization interface [polypeptide binding]; other site 66692003801 putative DNA binding site [nucleotide binding]; other site 66692003802 putative Zn2+ binding site [ion binding]; other site 66692003803 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 66692003804 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 66692003805 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692003806 dimerization interface [polypeptide binding]; other site 66692003807 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692003808 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692003809 dimer interface [polypeptide binding]; other site 66692003810 phosphorylation site [posttranslational modification] 66692003811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003812 ATP binding site [chemical binding]; other site 66692003813 Mg2+ binding site [ion binding]; other site 66692003814 G-X-G motif; other site 66692003815 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692003816 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003817 active site 66692003818 phosphorylation site [posttranslational modification] 66692003819 intermolecular recognition site; other site 66692003820 dimerization interface [polypeptide binding]; other site 66692003821 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692003822 DNA binding site [nucleotide binding] 66692003823 Agmatinase-like family; Region: Agmatinase-like; cd09990 66692003824 active site 66692003825 oligomer interface [polypeptide binding]; other site 66692003826 Mn binding site [ion binding]; other site 66692003827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 66692003828 YheO-like PAS domain; Region: PAS_6; pfam08348 66692003829 HTH domain; Region: HTH_22; pfam13309 66692003830 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 66692003831 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 66692003832 threonine dehydratase; Provisional; Region: eutB; PRK07476 66692003833 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692003834 catalytic residue [active] 66692003835 ectoine utilization protein EutC; Validated; Region: PRK08291 66692003836 ornithine cyclodeaminase; Validated; Region: PRK06199; cl17400 66692003837 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 66692003838 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 66692003839 Spore germination protein; Region: Spore_permease; cl17796 66692003840 LysE type translocator; Region: LysE; pfam01810 66692003841 Manganese containing catalase; Region: Mn_catalase; pfam05067 66692003842 dinuclear metal binding motif [ion binding]; other site 66692003843 carboxyl-terminal processing protease; Provisional; Region: PLN00049 66692003844 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692003845 Mg-dependent tRNAse of the contact-dependent growth inhibition (CDI) system of Burkholderia pseudomallei 1026b, and related proteins; Region: CDI_toxin_Bp1026b_like; cd13442 66692003846 inhibitor binding site [polypeptide binding]; inhibition site 66692003847 putative metal binding site [ion binding]; other site 66692003848 SMI1-KNR4 cell-wall; Region: SUKH_6; pfam14568 66692003849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 66692003850 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 66692003851 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 66692003852 DinB superfamily; Region: DinB_2; pfam12867 66692003853 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 66692003854 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692003855 DNA-binding site [nucleotide binding]; DNA binding site 66692003856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692003857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692003858 homodimer interface [polypeptide binding]; other site 66692003859 catalytic residue [active] 66692003860 LysE type translocator; Region: LysE; cl00565 66692003861 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 66692003862 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692003863 putative DNA binding site [nucleotide binding]; other site 66692003864 putative Zn2+ binding site [ion binding]; other site 66692003865 AsnC family; Region: AsnC_trans_reg; pfam01037 66692003866 Uncharacterized conserved protein [Function unknown]; Region: COG2128 66692003867 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 66692003868 Transposase, Mutator family; Region: Transposase_mut; cl19537 66692003869 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692003870 HAMP domain; Region: HAMP; pfam00672 66692003871 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692003872 dimer interface [polypeptide binding]; other site 66692003873 phosphorylation site [posttranslational modification] 66692003874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003875 ATP binding site [chemical binding]; other site 66692003876 Mg2+ binding site [ion binding]; other site 66692003877 G-X-G motif; other site 66692003878 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692003879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692003880 active site 66692003881 phosphorylation site [posttranslational modification] 66692003882 intermolecular recognition site; other site 66692003883 dimerization interface [polypeptide binding]; other site 66692003884 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692003885 DNA binding site [nucleotide binding] 66692003886 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 66692003887 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 66692003888 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 66692003889 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 66692003890 Walker A/P-loop; other site 66692003891 ATP binding site [chemical binding]; other site 66692003892 Q-loop/lid; other site 66692003893 ABC transporter signature motif; other site 66692003894 Walker B; other site 66692003895 D-loop; other site 66692003896 H-loop/switch region; other site 66692003897 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692003898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003899 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692003900 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692003901 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 66692003902 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692003903 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692003904 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692003905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003906 dimer interface [polypeptide binding]; other site 66692003907 conserved gate region; other site 66692003908 putative PBP binding loops; other site 66692003909 ABC-ATPase subunit interface; other site 66692003910 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692003911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003912 dimer interface [polypeptide binding]; other site 66692003913 conserved gate region; other site 66692003914 putative PBP binding loops; other site 66692003915 ABC-ATPase subunit interface; other site 66692003916 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 66692003917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692003918 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692003919 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692003920 non-specific DNA binding site [nucleotide binding]; other site 66692003921 salt bridge; other site 66692003922 sequence-specific DNA binding site [nucleotide binding]; other site 66692003923 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 66692003924 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692003925 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 66692003926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692003927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692003928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692003929 dimerization interface [polypeptide binding]; other site 66692003930 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 66692003931 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 66692003932 hinge; other site 66692003933 active site 66692003934 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 66692003935 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 66692003936 FAD binding domain; Region: FAD_binding_4; pfam01565 66692003937 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 66692003938 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692003939 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 66692003940 putative active site [active] 66692003941 heme pocket [chemical binding]; other site 66692003942 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 66692003943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692003944 putative active site [active] 66692003945 heme pocket [chemical binding]; other site 66692003946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692003947 dimer interface [polypeptide binding]; other site 66692003948 phosphorylation site [posttranslational modification] 66692003949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692003950 ATP binding site [chemical binding]; other site 66692003951 Mg2+ binding site [ion binding]; other site 66692003952 G-X-G motif; other site 66692003953 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 66692003954 putative deacylase active site [active] 66692003955 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 66692003956 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692003957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003958 dimer interface [polypeptide binding]; other site 66692003959 conserved gate region; other site 66692003960 putative PBP binding loops; other site 66692003961 ABC-ATPase subunit interface; other site 66692003962 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692003963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692003964 dimer interface [polypeptide binding]; other site 66692003965 conserved gate region; other site 66692003966 putative PBP binding loops; other site 66692003967 ABC-ATPase subunit interface; other site 66692003968 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 66692003969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692003970 Walker A/P-loop; other site 66692003971 ATP binding site [chemical binding]; other site 66692003972 Q-loop/lid; other site 66692003973 ABC transporter signature motif; other site 66692003974 Walker B; other site 66692003975 D-loop; other site 66692003976 H-loop/switch region; other site 66692003977 TOBE-like domain; Region: TOBE_3; pfam12857 66692003978 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 66692003979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692003980 Walker A/P-loop; other site 66692003981 ATP binding site [chemical binding]; other site 66692003982 Q-loop/lid; other site 66692003983 ABC transporter signature motif; other site 66692003984 Walker B; other site 66692003985 D-loop; other site 66692003986 H-loop/switch region; other site 66692003987 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 66692003988 TM-ABC transporter signature motif; other site 66692003989 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 66692003990 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 66692003991 zinc binding site [ion binding]; other site 66692003992 putative ligand binding site [chemical binding]; other site 66692003993 Sulphur transport; Region: Sulf_transp; cl19477 66692003994 Sulphur transport; Region: Sulf_transp; cl19477 66692003995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692003996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692003997 Coenzyme A binding pocket [chemical binding]; other site 66692003998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 66692003999 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692004000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692004001 Walker A/P-loop; other site 66692004002 ATP binding site [chemical binding]; other site 66692004003 Q-loop/lid; other site 66692004004 ABC transporter signature motif; other site 66692004005 Walker B; other site 66692004006 D-loop; other site 66692004007 H-loop/switch region; other site 66692004008 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692004009 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 66692004010 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692004011 Walker A/P-loop; other site 66692004012 ATP binding site [chemical binding]; other site 66692004013 Q-loop/lid; other site 66692004014 ABC transporter signature motif; other site 66692004015 Walker B; other site 66692004016 D-loop; other site 66692004017 H-loop/switch region; other site 66692004018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692004019 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692004020 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 66692004021 peptide binding site [polypeptide binding]; other site 66692004022 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692004023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692004024 dimer interface [polypeptide binding]; other site 66692004025 conserved gate region; other site 66692004026 putative PBP binding loops; other site 66692004027 ABC-ATPase subunit interface; other site 66692004028 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692004029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692004030 dimer interface [polypeptide binding]; other site 66692004031 conserved gate region; other site 66692004032 putative PBP binding loops; other site 66692004033 ABC-ATPase subunit interface; other site 66692004034 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692004035 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692004036 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 66692004037 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 66692004038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692004039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692004040 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 66692004041 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 66692004042 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK07634 66692004043 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 66692004044 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 66692004045 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 66692004046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692004047 dimer interface [polypeptide binding]; other site 66692004048 conserved gate region; other site 66692004049 putative PBP binding loops; other site 66692004050 ABC-ATPase subunit interface; other site 66692004051 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 66692004052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692004053 dimer interface [polypeptide binding]; other site 66692004054 conserved gate region; other site 66692004055 putative PBP binding loops; other site 66692004056 ABC-ATPase subunit interface; other site 66692004057 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 66692004058 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 66692004059 Walker A/P-loop; other site 66692004060 ATP binding site [chemical binding]; other site 66692004061 Q-loop/lid; other site 66692004062 ABC transporter signature motif; other site 66692004063 Walker B; other site 66692004064 D-loop; other site 66692004065 H-loop/switch region; other site 66692004066 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 66692004067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692004068 substrate binding pocket [chemical binding]; other site 66692004069 membrane-bound complex binding site; other site 66692004070 hinge residues; other site 66692004071 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 66692004072 Part of AAA domain; Region: AAA_19; pfam13245 66692004073 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 66692004074 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692004075 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692004076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004077 Walker A/P-loop; other site 66692004078 ATP binding site [chemical binding]; other site 66692004079 Q-loop/lid; other site 66692004080 ABC transporter signature motif; other site 66692004081 Walker B; other site 66692004082 D-loop; other site 66692004083 H-loop/switch region; other site 66692004084 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692004085 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692004086 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 66692004087 Walker A/P-loop; other site 66692004088 ATP binding site [chemical binding]; other site 66692004089 Q-loop/lid; other site 66692004090 ABC transporter signature motif; other site 66692004091 Walker B; other site 66692004092 D-loop; other site 66692004093 H-loop/switch region; other site 66692004094 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 66692004095 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692004096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692004097 dimer interface [polypeptide binding]; other site 66692004098 phosphorylation site [posttranslational modification] 66692004099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692004100 ATP binding site [chemical binding]; other site 66692004101 Mg2+ binding site [ion binding]; other site 66692004102 G-X-G motif; other site 66692004103 glycerol kinase; Provisional; Region: glpK; PRK00047 66692004104 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 66692004105 N- and C-terminal domain interface [polypeptide binding]; other site 66692004106 active site 66692004107 MgATP binding site [chemical binding]; other site 66692004108 catalytic site [active] 66692004109 metal binding site [ion binding]; metal-binding site 66692004110 glycerol binding site [chemical binding]; other site 66692004111 homotetramer interface [polypeptide binding]; other site 66692004112 homodimer interface [polypeptide binding]; other site 66692004113 FBP binding site [chemical binding]; other site 66692004114 protein IIAGlc interface [polypeptide binding]; other site 66692004115 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 66692004116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004117 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 66692004118 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 66692004119 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 66692004120 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 66692004121 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 66692004122 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 66692004123 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692004124 active site turn [active] 66692004125 phosphorylation site [posttranslational modification] 66692004126 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692004127 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 66692004128 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 66692004129 Ca binding site [ion binding]; other site 66692004130 active site 66692004131 catalytic site [active] 66692004132 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 66692004133 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 66692004134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692004135 DNA-binding site [nucleotide binding]; DNA binding site 66692004136 UTRA domain; Region: UTRA; pfam07702 66692004137 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 66692004138 catalytic residues [active] 66692004139 dimer interface [polypeptide binding]; other site 66692004140 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 66692004141 active site 66692004142 dimer interface [polypeptide binding]; other site 66692004143 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 66692004144 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692004145 ABC transporter; Region: ABC_tran_2; pfam12848 66692004146 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692004147 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692004148 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 66692004149 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692004150 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 66692004151 putative substrate binding site [chemical binding]; other site 66692004152 putative ATP binding site [chemical binding]; other site 66692004153 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 66692004154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692004155 active site 66692004156 phosphorylation site [posttranslational modification] 66692004157 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 66692004158 active site 66692004159 P-loop; other site 66692004160 phosphorylation site [posttranslational modification] 66692004161 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 66692004162 rod-share determining protein MreBH; Provisional; Region: PRK13929 66692004163 MreB and similar proteins; Region: MreB_like; cd10225 66692004164 nucleotide binding site [chemical binding]; other site 66692004165 Mg binding site [ion binding]; other site 66692004166 putative protofilament interaction site [polypeptide binding]; other site 66692004167 RodZ interaction site [polypeptide binding]; other site 66692004168 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 66692004169 Na2 binding site [ion binding]; other site 66692004170 putative substrate binding site 1 [chemical binding]; other site 66692004171 Na binding site 1 [ion binding]; other site 66692004172 putative substrate binding site 2 [chemical binding]; other site 66692004173 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 66692004174 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 66692004175 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 66692004176 Ribonuclease H-like superfamily, including RNase H, HI, HII, HIII, and RNase-like domain IV of spliceosomal protein Prp8; Region: RNase_H_like; cl14782 66692004177 RNA/DNA hybrid binding site [nucleotide binding]; other site 66692004178 active site 66692004179 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 66692004180 NAD(P) binding site [chemical binding]; other site 66692004181 catalytic residues [active] 66692004182 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 66692004183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004184 Transposase IS200 like; Region: Y1_Tnp; pfam01797 66692004185 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 66692004186 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 66692004187 tetramer interface [polypeptide binding]; other site 66692004188 heme binding pocket [chemical binding]; other site 66692004189 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 66692004190 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 66692004191 active site 66692004192 Zn binding site [ion binding]; other site 66692004193 Outer membrane lipoprotein LolB; Region: LolB; cl19307 66692004194 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 66692004195 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 66692004196 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 66692004197 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 66692004198 YtxH-like protein; Region: YtxH; cl02079 66692004199 YfkD-like protein; Region: YfkD; pfam14167 66692004200 Radical SAM superfamily; Region: Radical_SAM; pfam04055 66692004201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692004202 FeS/SAM binding site; other site 66692004203 YfkB-like domain; Region: YfkB; pfam08756 66692004204 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 66692004205 catalytic core [active] 66692004206 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 66692004207 Domain of unknown function DUF21; Region: DUF21; pfam01595 66692004208 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 66692004209 Transporter associated domain; Region: CorC_HlyC; smart01091 66692004210 Domain of unknown function (DUF368); Region: DUF368; pfam04018 66692004211 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 66692004212 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 66692004213 NodB motif; other site 66692004214 active site 66692004215 catalytic site [active] 66692004216 Cd binding site [ion binding]; other site 66692004217 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 66692004218 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004219 Predicted transcriptional regulator [Transcription]; Region: COG1959 66692004220 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692004221 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692004222 putative DNA binding site [nucleotide binding]; other site 66692004223 putative Zn2+ binding site [ion binding]; other site 66692004224 TRAM domain; Region: TRAM; pfam01938 66692004225 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 66692004226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692004227 S-adenosylmethionine binding site [chemical binding]; other site 66692004228 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 66692004229 putative dimer interface [polypeptide binding]; other site 66692004230 catalytic triad [active] 66692004231 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 66692004232 TIGR01777 family protein; Region: yfcH 66692004233 putative NAD(P) binding site [chemical binding]; other site 66692004234 putative active site [active] 66692004235 recombination regulator RecX; Provisional; Region: recX; PRK14135 66692004236 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 66692004237 YpzG-like protein; Region: YpzG; pfam14139 66692004238 Small acid-soluble spore protein K family; Region: SspK; pfam08176 66692004239 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 66692004240 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 66692004241 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 66692004242 minor groove reading motif; other site 66692004243 helix-hairpin-helix signature motif; other site 66692004244 substrate binding pocket [chemical binding]; other site 66692004245 active site 66692004246 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 66692004247 DNA binding and oxoG recognition site [nucleotide binding] 66692004248 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 66692004249 classical (c) SDRs; Region: SDR_c; cd05233 66692004250 NAD(P) binding site [chemical binding]; other site 66692004251 active site 66692004252 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 66692004253 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 66692004254 putative NAD(P) binding site [chemical binding]; other site 66692004255 active site 66692004256 Small, acid-soluble spore protein, gamma-type; Region: SASP_gamma; pfam04259 66692004257 hypothetical protein; Provisional; Region: PRK13662 66692004258 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692004259 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692004260 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 66692004261 Walker A/P-loop; other site 66692004262 ATP binding site [chemical binding]; other site 66692004263 Q-loop/lid; other site 66692004264 ABC transporter signature motif; other site 66692004265 Walker B; other site 66692004266 D-loop; other site 66692004267 H-loop/switch region; other site 66692004268 Predicted membrane protein [Function unknown]; Region: COG4129 66692004269 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 66692004270 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 66692004271 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692004272 inhibitor-cofactor binding pocket; inhibition site 66692004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692004274 catalytic residue [active] 66692004275 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 66692004276 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 66692004277 catalytic triad [active] 66692004278 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 66692004279 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 66692004280 NAD binding site [chemical binding]; other site 66692004281 ligand binding site [chemical binding]; other site 66692004282 catalytic site [active] 66692004283 Protein of unknown function (DUF970); Region: DUF970; cl17525 66692004284 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 66692004285 metal binding site 2 [ion binding]; metal-binding site 66692004286 putative DNA binding helix; other site 66692004287 metal binding site 1 [ion binding]; metal-binding site 66692004288 dimer interface [polypeptide binding]; other site 66692004289 structural Zn2+ binding site [ion binding]; other site 66692004290 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 66692004291 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 66692004292 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 66692004293 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 66692004294 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 66692004295 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 66692004296 active site 66692004297 DNA binding site [nucleotide binding] 66692004298 Int/Topo IB signature motif; other site 66692004299 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 66692004300 active site 66692004301 Phage terminase, small subunit; Region: Terminase_4; pfam05119 66692004302 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 66692004303 Phage Terminase; Region: Terminase_1; cl19862 66692004304 Phage portal protein; Region: Phage_portal; pfam04860 66692004305 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 66692004306 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 66692004307 Phage capsid family; Region: Phage_capsid; pfam05065 66692004308 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 66692004309 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 66692004310 Interdomain contacts; other site 66692004311 Cytokine receptor motif; other site 66692004312 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 66692004313 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 66692004314 oligomerization interface [polypeptide binding]; other site 66692004315 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 66692004316 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 66692004317 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 66692004318 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 66692004319 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 66692004320 Phage-related tail protein [Function unknown]; Region: COG5283 66692004321 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 66692004322 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 66692004323 Peptidase family M23; Region: Peptidase_M23; pfam01551 66692004324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 66692004325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 66692004326 catalytic residue [active] 66692004327 Phage tail protein; Region: Sipho_tail; pfam05709 66692004328 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 66692004329 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 66692004330 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 66692004331 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 66692004332 Holin family; Region: Phage_holin_4; pfam05105 66692004333 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 66692004334 amidase catalytic site [active] 66692004335 Zn binding residues [ion binding]; other site 66692004336 substrate binding site [chemical binding]; other site 66692004337 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 66692004338 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692004339 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692004340 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 66692004341 YolD-like protein; Region: YolD; pfam08863 66692004342 Domain of unknown function (DUF955); Region: DUF955; pfam06114 66692004343 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692004344 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692004345 sequence-specific DNA binding site [nucleotide binding]; other site 66692004346 salt bridge; other site 66692004347 Helix-turn-helix; Region: HTH_3; pfam01381 66692004348 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; pfam07352 66692004349 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 66692004350 Protein of unknown function (DUF669); Region: DUF669; pfam05037 66692004351 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 66692004352 D5 N terminal like; Region: D5_N; smart00885 66692004353 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 66692004354 ERCC4 domain; Region: ERCC4; pfam02732 66692004355 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 66692004356 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 66692004357 putative nucleotide binding site [chemical binding]; other site 66692004358 putative metal binding site [ion binding]; other site 66692004359 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 66692004360 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692004361 dimerization interface [polypeptide binding]; other site 66692004362 putative DNA binding site [nucleotide binding]; other site 66692004363 putative Zn2+ binding site [ion binding]; other site 66692004364 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 66692004365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692004366 putative substrate translocation pore; other site 66692004367 hypothetical protein; Provisional; Region: PRK08244 66692004368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004369 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 66692004370 homotrimer interaction site [polypeptide binding]; other site 66692004371 putative active site [active] 66692004372 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692004373 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692004374 putative Zn2+ binding site [ion binding]; other site 66692004375 putative DNA binding site [nucleotide binding]; other site 66692004376 dimerization interface [polypeptide binding]; other site 66692004377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004378 Walker A/P-loop; other site 66692004379 ATP binding site [chemical binding]; other site 66692004380 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 66692004381 Epoxide hydrolase N terminus; Region: EHN; pfam06441 66692004382 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692004383 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 66692004384 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692004385 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 66692004386 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692004387 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692004388 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692004389 Transcriptional regulator; Region: Rrf2; pfam02082 66692004390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692004391 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692004392 putative substrate translocation pore; other site 66692004393 hypothetical protein; Provisional; Region: PRK08233 66692004394 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 66692004395 active site 66692004396 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692004397 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 66692004398 DNA binding residues [nucleotide binding] 66692004399 dimer interface [polypeptide binding]; other site 66692004400 Beta-lactamase; Region: Beta-lactamase; pfam00144 66692004401 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 66692004402 Phosphotransferase enzyme family; Region: APH; pfam01636 66692004403 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 66692004404 active site 66692004405 substrate binding site [chemical binding]; other site 66692004406 ATP binding site [chemical binding]; other site 66692004407 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 66692004408 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 66692004409 Phosphotransferase enzyme family; Region: APH; pfam01636 66692004410 active site 66692004411 ATP binding site [chemical binding]; other site 66692004412 substrate binding site [chemical binding]; other site 66692004413 AAA ATPase domain; Region: AAA_15; pfam13175 66692004414 AAA domain; Region: AAA_23; pfam13476 66692004415 Walker A/P-loop; other site 66692004416 ATP binding site [chemical binding]; other site 66692004417 AAA domain; Region: AAA_21; pfam13304 66692004418 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 66692004419 putative active site [active] 66692004420 putative metal-binding site [ion binding]; other site 66692004421 transposase, IS256 family 66692004422 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692004423 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692004424 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692004425 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 66692004426 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 66692004427 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 66692004428 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 66692004429 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692004430 HTH domain; Region: HTH_11; cl17392 66692004431 PRD domain; Region: PRD; pfam00874 66692004432 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692004433 active site 66692004434 P-loop; other site 66692004435 phosphorylation site [posttranslational modification] 66692004436 dihydroorotase; Provisional; Region: PRK09237 66692004437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692004438 active site 66692004439 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 66692004440 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; pfam14272 66692004441 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 66692004442 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 66692004443 Domain of unknown function (DUF4310); Region: DUF4310; pfam14187 66692004444 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 66692004445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692004446 catalytic residue [active] 66692004447 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 66692004448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692004449 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 66692004450 active site 66692004451 catalytic tetrad [active] 66692004452 YjbR; Region: YjbR; pfam04237 66692004453 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 66692004454 putative dimer interface [polypeptide binding]; other site 66692004455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692004456 Helix-turn-helix domain; Region: HTH_18; pfam12833 66692004457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692004458 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 66692004459 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 66692004460 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 66692004461 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 66692004462 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 66692004463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692004464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692004465 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 66692004466 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 66692004467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692004469 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692004470 putative substrate translocation pore; other site 66692004471 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 66692004472 active site 66692004473 Mn binding site [ion binding]; other site 66692004474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692004475 dimerization interface [polypeptide binding]; other site 66692004476 putative DNA binding site [nucleotide binding]; other site 66692004477 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692004478 putative Zn2+ binding site [ion binding]; other site 66692004479 seryl-tRNA synthetase; Provisional; Region: PRK05431 66692004480 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 66692004481 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 66692004482 dimer interface [polypeptide binding]; other site 66692004483 active site 66692004484 motif 1; other site 66692004485 motif 2; other site 66692004486 motif 3; other site 66692004487 A new structural DNA glycosylase; Region: AlkD_like; cd06561 66692004488 active site 66692004489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004490 Walker A/P-loop; other site 66692004491 ATP binding site [chemical binding]; other site 66692004492 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 66692004493 catalytic core [active] 66692004494 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692004495 Histidine kinase; Region: HisKA_3; pfam07730 66692004496 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 66692004497 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692004498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692004499 active site 66692004500 phosphorylation site [posttranslational modification] 66692004501 intermolecular recognition site; other site 66692004502 dimerization interface [polypeptide binding]; other site 66692004503 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692004504 DNA binding residues [nucleotide binding] 66692004505 dimerization interface [polypeptide binding]; other site 66692004506 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692004507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004508 Walker A/P-loop; other site 66692004509 ATP binding site [chemical binding]; other site 66692004510 Q-loop/lid; other site 66692004511 ABC transporter signature motif; other site 66692004512 Walker B; other site 66692004513 D-loop; other site 66692004514 H-loop/switch region; other site 66692004515 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 66692004516 ABC-2 type transporter; Region: ABC2_membrane; cl17235 66692004517 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 66692004518 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 66692004519 ABC-2 type transporter; Region: ABC2_membrane; cl17235 66692004520 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 66692004521 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 66692004522 Ligand binding site; other site 66692004523 metal-binding site 66692004524 Tubby C 2; Region: Tub_2; cl02043 66692004525 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 66692004526 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692004527 intersubunit interface [polypeptide binding]; other site 66692004528 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 66692004529 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 66692004530 active site 66692004531 catalytic site [active] 66692004532 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692004533 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692004534 Coenzyme A binding pocket [chemical binding]; other site 66692004535 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 66692004536 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692004537 active site 66692004538 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 66692004539 Sulfate transporter family; Region: Sulfate_transp; cl19250 66692004540 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 66692004541 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 66692004542 active site 66692004543 metal binding site [ion binding]; metal-binding site 66692004544 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 66692004545 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 66692004546 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 66692004547 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 66692004548 aromatic chitin/cellulose binding site residues [chemical binding]; other site 66692004549 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 66692004550 aromatic chitin/cellulose binding site residues [chemical binding]; other site 66692004551 Regulatory protein YrvL; Region: YrvL; pfam14184 66692004552 SEC-C motif; Region: SEC-C; pfam02810 66692004553 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 66692004554 anion transporter; Region: dass; TIGR00785 66692004555 transmembrane helices; other site 66692004556 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 66692004557 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 66692004558 THF binding site; other site 66692004559 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 66692004560 substrate binding site [chemical binding]; other site 66692004561 THF binding site; other site 66692004562 zinc-binding site [ion binding]; other site 66692004563 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 66692004564 Carbon starvation protein CstA; Region: CstA; pfam02554 66692004565 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 66692004566 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 66692004567 tetramerization interface [polypeptide binding]; other site 66692004568 NAD(P) binding site [chemical binding]; other site 66692004569 catalytic residues [active] 66692004570 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 66692004571 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692004572 active site turn [active] 66692004573 phosphorylation site [posttranslational modification] 66692004574 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692004575 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 66692004576 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 66692004577 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 66692004578 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 66692004579 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 66692004580 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 66692004581 substrate binding [chemical binding]; other site 66692004582 active site 66692004583 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 66692004584 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692004585 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692004586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692004587 MepB protein; Region: MepB; pfam08877 66692004588 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692004589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004590 Walker A/P-loop; other site 66692004591 ATP binding site [chemical binding]; other site 66692004592 Q-loop/lid; other site 66692004593 ABC transporter signature motif; other site 66692004594 Walker B; other site 66692004595 D-loop; other site 66692004596 H-loop/switch region; other site 66692004597 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 66692004598 Predicted transcriptional regulators [Transcription]; Region: COG1725 66692004599 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692004600 DNA-binding site [nucleotide binding]; DNA binding site 66692004601 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 66692004602 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004603 Walker A/P-loop; other site 66692004604 ATP binding site [chemical binding]; other site 66692004605 Q-loop/lid; other site 66692004606 ABC transporter signature motif; other site 66692004607 Walker B; other site 66692004608 D-loop; other site 66692004609 H-loop/switch region; other site 66692004610 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 66692004611 putative oligomer interface [polypeptide binding]; other site 66692004612 putative active site [active] 66692004613 metal binding site [ion binding]; metal-binding site 66692004614 Ferritin-like domain; Region: Ferritin; pfam00210 66692004615 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 66692004616 dimerization interface [polypeptide binding]; other site 66692004617 DPS ferroxidase diiron center [ion binding]; other site 66692004618 ion pore; other site 66692004619 B3/4 domain; Region: B3_4; cl19243 66692004620 epoxyqueuosine reductase; Region: TIGR00276 66692004621 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 66692004622 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 66692004623 HEAT-like repeat; Region: HEAT_EZ; pfam13513 66692004624 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 66692004625 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 66692004626 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 66692004627 DNA binding site [nucleotide binding] 66692004628 active site 66692004629 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692004630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692004631 Coenzyme A binding pocket [chemical binding]; other site 66692004632 Putative amidase domain; Region: Amidase_6; pfam12671 66692004633 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 66692004634 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 66692004635 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 66692004636 Transglycosylase; Region: Transgly; pfam00912 66692004637 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 66692004638 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 66692004639 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 66692004640 PrkA AAA domain; Region: AAA_PrkA; smart00763 66692004641 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 66692004642 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 66692004643 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 66692004644 Catalytic site [active] 66692004645 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 66692004646 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 66692004647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 66692004648 Walker A/P-loop; other site 66692004649 ATP binding site [chemical binding]; other site 66692004650 Q-loop/lid; other site 66692004651 ABC transporter signature motif; other site 66692004652 Walker B; other site 66692004653 D-loop; other site 66692004654 H-loop/switch region; other site 66692004655 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 66692004656 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 66692004657 metal ion-dependent adhesion site (MIDAS); other site 66692004658 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692004659 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692004660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692004661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692004662 putative substrate translocation pore; other site 66692004663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004664 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 66692004665 Walker A/P-loop; other site 66692004666 ATP binding site [chemical binding]; other site 66692004667 Q-loop/lid; other site 66692004668 ABC transporter signature motif; other site 66692004669 Walker B; other site 66692004670 D-loop; other site 66692004671 H-loop/switch region; other site 66692004672 ABC-2 type transporter; Region: ABC2_membrane; cl17235 66692004673 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 66692004674 DinB superfamily; Region: DinB_2; pfam12867 66692004675 Pectinesterase; Region: Pectinesterase; cl01911 66692004676 Right handed beta helix region; Region: Beta_helix; pfam13229 66692004677 Right handed beta helix region; Region: Beta_helix; pfam13229 66692004678 Right handed beta helix region; Region: Beta_helix; pfam13229 66692004679 oxidoreductase; Provisional; Region: PRK06128 66692004680 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 66692004681 NAD binding site [chemical binding]; other site 66692004682 metal binding site [ion binding]; metal-binding site 66692004683 active site 66692004684 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 66692004685 Na binding site [ion binding]; other site 66692004686 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 66692004687 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692004688 DNA-binding site [nucleotide binding]; DNA binding site 66692004689 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 66692004690 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 66692004691 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 66692004692 active sites [active] 66692004693 tetramer interface [polypeptide binding]; other site 66692004694 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 66692004695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692004696 DNA-binding site [nucleotide binding]; DNA binding site 66692004697 UTRA domain; Region: UTRA; pfam07702 66692004698 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 66692004699 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 66692004700 active site 66692004701 dimer interface [polypeptide binding]; other site 66692004702 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 66692004703 active site 66692004704 trimer interface [polypeptide binding]; other site 66692004705 allosteric site; other site 66692004706 active site lid [active] 66692004707 hexamer (dimer of trimers) interface [polypeptide binding]; other site 66692004708 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 66692004709 dimer interface [polypeptide binding]; other site 66692004710 FMN binding site [chemical binding]; other site 66692004711 NADPH bind site [chemical binding]; other site 66692004712 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 66692004713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692004714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692004715 homodimer interface [polypeptide binding]; other site 66692004716 catalytic residue [active] 66692004717 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 66692004718 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 66692004719 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 66692004720 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 66692004721 active site 66692004722 catalytic site [active] 66692004723 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 66692004724 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 66692004725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692004726 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 66692004727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692004728 Coenzyme A binding pocket [chemical binding]; other site 66692004729 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 66692004730 putative active site [active] 66692004731 catalytic triad [active] 66692004732 putative dimer interface [polypeptide binding]; other site 66692004733 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 66692004734 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 66692004735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004736 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 66692004737 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 66692004738 active site 66692004739 substrate binding site [chemical binding]; other site 66692004740 metal binding site [ion binding]; metal-binding site 66692004741 SpoVR like protein; Region: SpoVR; cl19504 66692004742 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692004743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692004744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692004745 Walker A/P-loop; other site 66692004746 ATP binding site [chemical binding]; other site 66692004747 Q-loop/lid; other site 66692004748 ABC transporter signature motif; other site 66692004749 Walker B; other site 66692004750 D-loop; other site 66692004751 H-loop/switch region; other site 66692004752 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692004753 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692004754 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 66692004755 Walker A/P-loop; other site 66692004756 ATP binding site [chemical binding]; other site 66692004757 Q-loop/lid; other site 66692004758 ABC transporter signature motif; other site 66692004759 Walker B; other site 66692004760 D-loop; other site 66692004761 H-loop/switch region; other site 66692004762 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 66692004763 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692004764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692004765 homodimer interface [polypeptide binding]; other site 66692004766 catalytic residue [active] 66692004767 heat shock protein HtpX; Provisional; Region: PRK04897 66692004768 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 66692004769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 66692004770 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 66692004771 FAD binding site [chemical binding]; other site 66692004772 homotetramer interface [polypeptide binding]; other site 66692004773 substrate binding pocket [chemical binding]; other site 66692004774 catalytic base [active] 66692004775 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 66692004776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692004777 ATP-grasp domain; Region: ATP-grasp_4; cl17255 66692004778 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 66692004779 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 66692004780 carboxyltransferase (CT) interaction site; other site 66692004781 biotinylation site [posttranslational modification]; other site 66692004782 enoyl-CoA hydratase; Provisional; Region: PRK07657 66692004783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 66692004784 substrate binding site [chemical binding]; other site 66692004785 oxyanion hole (OAH) forming residues; other site 66692004786 trimer interface [polypeptide binding]; other site 66692004787 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 66692004788 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 66692004789 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 66692004790 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; pfam09501 66692004791 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 66692004792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692004793 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 66692004794 DNA binding residues [nucleotide binding] 66692004795 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 66692004796 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 66692004797 Walker A/P-loop; other site 66692004798 ATP binding site [chemical binding]; other site 66692004799 Q-loop/lid; other site 66692004800 ABC transporter signature motif; other site 66692004801 Walker B; other site 66692004802 D-loop; other site 66692004803 H-loop/switch region; other site 66692004804 TOBE domain; Region: TOBE_2; pfam08402 66692004805 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 66692004806 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692004807 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 66692004808 Protein of unknown function (DUF445); Region: DUF445; pfam04286 66692004809 hypothetical protein; Provisional; Region: PRK13676 66692004810 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 66692004811 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692004812 motif II; other site 66692004813 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692004814 YhzD-like protein; Region: YhzD; pfam14120 66692004815 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 66692004816 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692004817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692004818 active site 66692004819 phosphorylation site [posttranslational modification] 66692004820 intermolecular recognition site; other site 66692004821 dimerization interface [polypeptide binding]; other site 66692004822 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692004823 DNA binding site [nucleotide binding] 66692004824 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692004825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692004826 dimer interface [polypeptide binding]; other site 66692004827 phosphorylation site [posttranslational modification] 66692004828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692004829 ATP binding site [chemical binding]; other site 66692004830 Mg2+ binding site [ion binding]; other site 66692004831 G-X-G motif; other site 66692004832 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 66692004833 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 66692004834 generic binding surface II; other site 66692004835 generic binding surface I; other site 66692004836 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692004837 Zn2+ binding site [ion binding]; other site 66692004838 Mg2+ binding site [ion binding]; other site 66692004839 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 66692004840 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 66692004841 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK02998 66692004842 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 66692004843 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 66692004844 transcriptional regulator Hpr; Provisional; Region: PRK13777 66692004845 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692004846 YtxH-like protein; Region: YtxH; cl02079 66692004847 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 66692004848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692004849 catalytic residue [active] 66692004850 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 66692004851 HIT family signature motif; other site 66692004852 catalytic residue [active] 66692004853 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 66692004854 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692004855 Walker A/P-loop; other site 66692004856 ATP binding site [chemical binding]; other site 66692004857 Q-loop/lid; other site 66692004858 ABC transporter signature motif; other site 66692004859 Walker B; other site 66692004860 D-loop; other site 66692004861 H-loop/switch region; other site 66692004862 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 66692004863 EcsC protein family; Region: EcsC; pfam12787 66692004864 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 66692004865 Transglycosylase; Region: Transgly; pfam00912 66692004866 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 66692004867 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 66692004868 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 66692004869 substrate binding site [chemical binding]; other site 66692004870 active site 66692004871 ferrochelatase; Provisional; Region: PRK12435 66692004872 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 66692004873 C-terminal domain interface [polypeptide binding]; other site 66692004874 active site 66692004875 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 66692004876 active site 66692004877 N-terminal domain interface [polypeptide binding]; other site 66692004878 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 66692004879 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 66692004880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692004881 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 66692004882 Sporulation initiation phospho-transferase B, C-terminal; Region: SPOB_ab; pfam14682 66692004883 GTPase CgtA; Reviewed; Region: obgE; PRK12297 66692004884 GTP1/OBG; Region: GTP1_OBG; pfam01018 66692004885 Obg GTPase; Region: Obg; cd01898 66692004886 G1 box; other site 66692004887 GTP/Mg2+ binding site [chemical binding]; other site 66692004888 Switch I region; other site 66692004889 G2 box; other site 66692004890 G3 box; other site 66692004891 Switch II region; other site 66692004892 G4 box; other site 66692004893 G5 box; other site 66692004894 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 66692004895 hypothetical protein; Provisional; Region: PRK04435 66692004896 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 66692004897 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 66692004898 prephenate dehydratase; Provisional; Region: PRK11898 66692004899 Prephenate dehydratase; Region: PDT; pfam00800 66692004900 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 66692004901 putative L-Phe binding site [chemical binding]; other site 66692004902 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 66692004903 HTH domain; Region: HTH_11; pfam08279 66692004904 3H domain; Region: 3H; pfam02829 66692004905 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 66692004906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692004907 catalytic residue [active] 66692004908 L-aspartate oxidase; Provisional; Region: PRK08071 66692004909 L-aspartate oxidase; Provisional; Region: PRK06175 66692004910 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 66692004911 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 66692004912 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 66692004913 dimerization interface [polypeptide binding]; other site 66692004914 active site 66692004915 quinolinate synthetase; Provisional; Region: PRK09375 66692004916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692004917 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 66692004918 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 66692004919 Cupredoxin superfamily; Region: Cupredoxin; cl19115 66692004920 Bypass of Forespore C, N terminal; Region: BOFC_N; pfam08977 66692004921 BofC C-terminal domain; Region: BofC_C; pfam08955 66692004922 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 66692004923 RuvA N terminal domain; Region: RuvA_N; pfam01330 66692004924 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 66692004925 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 66692004926 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 66692004927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692004928 Walker A motif; other site 66692004929 ATP binding site [chemical binding]; other site 66692004930 Walker B motif; other site 66692004931 arginine finger; other site 66692004932 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 66692004933 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 66692004934 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 66692004935 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 66692004936 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 66692004937 Preprotein translocase subunit; Region: YajC; pfam02699 66692004938 Protein of unknown function (DUF3792); Region: DUF3792; pfam12670 66692004939 Protein of unknown function (DUF421); Region: DUF421; cl00990 66692004940 stage V sporulation protein B; Region: spore_V_B; TIGR02900 66692004941 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 66692004942 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 66692004943 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 66692004944 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 66692004945 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 66692004946 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 66692004947 Protein export membrane protein; Region: SecD_SecF; pfam02355 66692004948 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 66692004949 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 66692004950 DHH family; Region: DHH; pfam01368 66692004951 DHHA1 domain; Region: DHHA1; pfam02272 66692004952 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 66692004953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692004954 active site 66692004955 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 66692004956 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692004957 Zn2+ binding site [ion binding]; other site 66692004958 Mg2+ binding site [ion binding]; other site 66692004959 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 66692004960 synthetase active site [active] 66692004961 NTP binding site [chemical binding]; other site 66692004962 metal binding site [ion binding]; metal-binding site 66692004963 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 66692004964 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 66692004965 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 66692004966 putative active site [active] 66692004967 dimerization interface [polypeptide binding]; other site 66692004968 putative tRNAtyr binding site [nucleotide binding]; other site 66692004969 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692004970 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692004971 DNA binding site [nucleotide binding] 66692004972 domain linker motif; other site 66692004973 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 66692004974 putative dimerization interface [polypeptide binding]; other site 66692004975 putative ligand binding site [chemical binding]; other site 66692004976 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 66692004977 conserved cys residue [active] 66692004978 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692004979 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692004980 Beta-lactamase; Region: Beta-lactamase; pfam00144 66692004981 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 66692004982 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 66692004983 dimer interface [polypeptide binding]; other site 66692004984 motif 1; other site 66692004985 active site 66692004986 motif 2; other site 66692004987 motif 3; other site 66692004988 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 66692004989 anticodon binding site; other site 66692004990 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 66692004991 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 66692004992 dimer interface [polypeptide binding]; other site 66692004993 anticodon binding site; other site 66692004994 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 66692004995 homodimer interface [polypeptide binding]; other site 66692004996 motif 1; other site 66692004997 active site 66692004998 motif 2; other site 66692004999 GAD domain; Region: GAD; pfam02938 66692005000 motif 3; other site 66692005001 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 66692005002 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 66692005003 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 66692005004 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 66692005005 substrate binding site [chemical binding]; other site 66692005006 zinc-binding site [ion binding]; other site 66692005007 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 66692005008 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 66692005009 putative ATP binding site [chemical binding]; other site 66692005010 putative substrate interface [chemical binding]; other site 66692005011 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 66692005012 recombination factor protein RarA; Reviewed; Region: PRK13342 66692005013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692005014 Walker A motif; other site 66692005015 ATP binding site [chemical binding]; other site 66692005016 Walker B motif; other site 66692005017 arginine finger; other site 66692005018 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 66692005019 Predicted transcriptional regulator [Transcription]; Region: COG1959 66692005020 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692005021 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 66692005022 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692005023 catalytic residue [active] 66692005024 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 66692005025 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 66692005026 Ligand Binding Site [chemical binding]; other site 66692005027 Tetratricopeptide repeat; Region: TPR_16; pfam13432 66692005028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692005029 TPR motif; other site 66692005030 binding surface 66692005031 TPR repeat; Region: TPR_11; pfam13414 66692005032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692005033 binding surface 66692005034 TPR motif; other site 66692005035 TPR repeat; Region: TPR_11; pfam13414 66692005036 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 66692005037 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 66692005038 Helix-hairpin-helix containing domain; Region: HHH_4; pfam14490 66692005039 AAA domain; Region: AAA_30; pfam13604 66692005040 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 66692005041 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 66692005042 PRC-barrel domain; Region: PRC; pfam05239 66692005043 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 66692005044 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 66692005045 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 66692005046 motif 1; other site 66692005047 active site 66692005048 motif 2; other site 66692005049 motif 3; other site 66692005050 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 66692005051 DHHA1 domain; Region: DHHA1; pfam02272 66692005052 hypothetical protein; Provisional; Region: PRK05473 66692005053 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 66692005054 hypothetical protein; Provisional; Region: PRK13678 66692005055 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 66692005056 dimerization interface [polypeptide binding]; other site 66692005057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692005058 S-adenosylmethionine binding site [chemical binding]; other site 66692005059 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 66692005060 ATP-binding site [chemical binding]; other site 66692005061 Sugar specificity; other site 66692005062 Pyrimidine base specificity; other site 66692005063 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 66692005064 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 66692005065 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 66692005066 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 66692005067 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 66692005068 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 66692005069 active site 66692005070 DNA binding site [nucleotide binding] 66692005071 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 66692005072 nucleotide binding site [chemical binding]; other site 66692005073 Ku-homolog [Replication, recombination, and repair]; Region: COG1273 66692005074 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 66692005075 putative DNA binding site [nucleotide binding]; other site 66692005076 putative homodimer interface [polypeptide binding]; other site 66692005077 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 66692005078 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692005079 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 66692005080 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 66692005081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692005082 Walker A/P-loop; other site 66692005083 ATP binding site [chemical binding]; other site 66692005084 Q-loop/lid; other site 66692005085 ABC transporter signature motif; other site 66692005086 Walker B; other site 66692005087 D-loop; other site 66692005088 H-loop/switch region; other site 66692005089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692005090 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 66692005091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692005092 Walker A/P-loop; other site 66692005093 ATP binding site [chemical binding]; other site 66692005094 Q-loop/lid; other site 66692005095 ABC transporter signature motif; other site 66692005096 Walker B; other site 66692005097 D-loop; other site 66692005098 H-loop/switch region; other site 66692005099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692005100 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692005101 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692005102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692005103 dimer interface [polypeptide binding]; other site 66692005104 conserved gate region; other site 66692005105 putative PBP binding loops; other site 66692005106 ABC-ATPase subunit interface; other site 66692005107 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692005108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692005109 dimer interface [polypeptide binding]; other site 66692005110 conserved gate region; other site 66692005111 putative PBP binding loops; other site 66692005112 ABC-ATPase subunit interface; other site 66692005113 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692005114 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692005115 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 66692005116 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 66692005117 active site 66692005118 catalytic site [active] 66692005119 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 66692005120 Carbohydrate binding domain; Region: CBM_25; smart01066 66692005121 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 66692005122 putative active site [active] 66692005123 putative CoA binding site [chemical binding]; other site 66692005124 nudix motif; other site 66692005125 metal binding site [ion binding]; metal-binding site 66692005126 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 66692005127 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 66692005128 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 66692005129 Predicted membrane protein [Function unknown]; Region: COG1288 66692005130 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 66692005131 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692005132 metal binding site [ion binding]; metal-binding site 66692005133 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 66692005134 sporulation sigma factor SigK; Reviewed; Region: PRK05803 66692005135 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692005136 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692005137 DNA binding residues [nucleotide binding] 66692005138 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 66692005139 active site 66692005140 SAM binding site [chemical binding]; other site 66692005141 homodimer interface [polypeptide binding]; other site 66692005142 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 66692005143 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 66692005144 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692005145 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692005146 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 66692005147 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 66692005148 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 66692005149 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 66692005150 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 66692005151 [2Fe-2S] cluster binding site [ion binding]; other site 66692005152 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 66692005153 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692005154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692005155 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 66692005156 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 66692005157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 66692005158 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 66692005159 molybdopterin cofactor binding site; other site 66692005160 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 66692005161 molybdopterin cofactor binding site; other site 66692005162 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 66692005163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692005164 putative substrate translocation pore; other site 66692005165 BCCT family transporter; Region: BCCT; pfam02028 66692005166 Protein of unknown function (DUF1168); Region: DUF1168; pfam06658 66692005167 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 66692005168 dimer interface [polypeptide binding]; other site 66692005169 substrate binding site [chemical binding]; other site 66692005170 ATP binding site [chemical binding]; other site 66692005171 histone-like DNA-binding protein HU; Region: HU; cd13831 66692005172 dimer interface [polypeptide binding]; other site 66692005173 DNA binding site [nucleotide binding] 66692005174 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 66692005175 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12600 66692005176 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 66692005177 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691 66692005178 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 66692005179 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK08600 66692005180 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 66692005181 monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12645 66692005182 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 66692005183 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 66692005184 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 66692005185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692005186 active site 66692005187 motif I; other site 66692005188 motif II; other site 66692005189 GTPase YqeH; Provisional; Region: PRK13796 66692005190 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 66692005191 GTP/Mg2+ binding site [chemical binding]; other site 66692005192 G4 box; other site 66692005193 G5 box; other site 66692005194 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 66692005195 G1 box; other site 66692005196 G1 box; other site 66692005197 GTP/Mg2+ binding site [chemical binding]; other site 66692005198 Switch I region; other site 66692005199 G2 box; other site 66692005200 G2 box; other site 66692005201 G3 box; other site 66692005202 G3 box; other site 66692005203 Switch II region; other site 66692005204 Switch II region; other site 66692005205 G4 box; other site 66692005206 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 66692005207 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 66692005208 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 66692005209 shikimate binding site; other site 66692005210 NAD(P) binding site [chemical binding]; other site 66692005211 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 66692005212 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 66692005213 active site 66692005214 (T/H)XGH motif; other site 66692005215 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692005216 Zn2+ binding site [ion binding]; other site 66692005217 Mg2+ binding site [ion binding]; other site 66692005218 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 66692005219 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 66692005220 S1 domain; Region: S1_2; pfam13509 66692005221 MarR family; Region: MarR_2; pfam12802 66692005222 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692005223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692005224 S-adenosylmethionine binding site [chemical binding]; other site 66692005225 late competence protein ComER; Validated; Region: PRK07680 66692005226 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 66692005227 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 66692005228 SLBB domain; Region: SLBB; pfam10531 66692005229 comEA protein; Region: comE; TIGR01259 66692005230 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 66692005231 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 66692005232 catalytic motif [active] 66692005233 Zn binding site [ion binding]; other site 66692005234 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 66692005235 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 66692005236 Competence protein; Region: Competence; pfam03772 66692005237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 66692005238 YqzM-like protein; Region: YqzM; pfam14141 66692005239 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 66692005240 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 66692005241 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 66692005242 germination protease; Provisional; Region: PRK02858 66692005243 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 66692005244 stage II sporulation protein P; Region: spore_II_P; TIGR02867 66692005245 GTP-binding protein LepA; Provisional; Region: PRK05433 66692005246 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 66692005247 G1 box; other site 66692005248 putative GEF interaction site [polypeptide binding]; other site 66692005249 GTP/Mg2+ binding site [chemical binding]; other site 66692005250 Switch I region; other site 66692005251 G2 box; other site 66692005252 G3 box; other site 66692005253 Switch II region; other site 66692005254 G4 box; other site 66692005255 G5 box; other site 66692005256 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 66692005257 Elongation Factor G, domain II; Region: EFG_II; pfam14492 66692005258 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 66692005259 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 66692005260 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 66692005261 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692005262 FeS/SAM binding site; other site 66692005263 HemN C-terminal domain; Region: HemN_C; pfam06969 66692005264 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 66692005265 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 66692005266 HrcA protein C terminal domain; Region: HrcA; pfam01628 66692005267 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 66692005268 dimer interface [polypeptide binding]; other site 66692005269 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 66692005270 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 66692005271 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 66692005272 nucleotide binding site [chemical binding]; other site 66692005273 NEF interaction site [polypeptide binding]; other site 66692005274 SBD interface [polypeptide binding]; other site 66692005275 chaperone protein DnaJ; Provisional; Region: PRK14287 66692005276 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 66692005277 HSP70 interaction site [polypeptide binding]; other site 66692005278 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 66692005279 substrate binding site [polypeptide binding]; other site 66692005280 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 66692005281 Zn binding sites [ion binding]; other site 66692005282 dimer interface [polypeptide binding]; other site 66692005283 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 66692005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692005285 S-adenosylmethionine binding site [chemical binding]; other site 66692005286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 66692005287 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 66692005288 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 66692005289 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692005290 FeS/SAM binding site; other site 66692005291 TRAM domain; Region: TRAM; cl01282 66692005292 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692005293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692005294 S-adenosylmethionine binding site [chemical binding]; other site 66692005295 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 66692005296 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 66692005297 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 66692005298 intersubunit interface [polypeptide binding]; other site 66692005299 active site 66692005300 catalytic residue [active] 66692005301 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692005302 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 66692005303 active site 66692005304 catalytic tetrad [active] 66692005305 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 66692005306 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 66692005307 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 66692005308 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 66692005309 Yqey-like protein; Region: YqeY; pfam09424 66692005310 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 66692005311 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 66692005312 dimer interface [polypeptide binding]; other site 66692005313 active site residues [active] 66692005314 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 66692005315 hypothetical protein; Provisional; Region: PRK13665 66692005316 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 66692005317 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 66692005318 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 66692005319 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 66692005320 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 66692005321 PhoH-like protein; Region: PhoH; pfam02562 66692005322 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 66692005323 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 66692005324 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692005325 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692005326 Zn2+ binding site [ion binding]; other site 66692005327 Mg2+ binding site [ion binding]; other site 66692005328 metal-binding heat shock protein; Provisional; Region: PRK00016 66692005329 Integral membrane undecaprenol kinase and similar enzymes; Region: UDPK_IM_like; cd14265 66692005330 trimer interface [polypeptide binding]; other site 66692005331 putative active site [active] 66692005332 Zn binding site [ion binding]; other site 66692005333 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 66692005334 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 66692005335 active site 66692005336 catalytic motif [active] 66692005337 Zn binding site [ion binding]; other site 66692005338 GTPase Era; Reviewed; Region: era; PRK00089 66692005339 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 66692005340 G1 box; other site 66692005341 GTP/Mg2+ binding site [chemical binding]; other site 66692005342 Switch I region; other site 66692005343 G2 box; other site 66692005344 Switch II region; other site 66692005345 G3 box; other site 66692005346 G4 box; other site 66692005347 G5 box; other site 66692005348 KH domain; Region: KH_2; pfam07650 66692005349 YqzL-like protein; Region: YqzL; pfam14006 66692005350 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 66692005351 Recombination protein O N terminal; Region: RecO_N; pfam11967 66692005352 Recombination protein O C terminal; Region: RecO_C; pfam02565 66692005353 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 66692005354 dimer interface [polypeptide binding]; other site 66692005355 motif 1; other site 66692005356 active site 66692005357 motif 2; other site 66692005358 motif 3; other site 66692005359 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 66692005360 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 66692005361 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 66692005362 HTH domain; Region: HTH_11; pfam08279 66692005363 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 66692005364 FOG: CBS domain [General function prediction only]; Region: COG0517 66692005365 PEP synthetase regulatory protein; Provisional; Region: PRK05339 66692005366 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 66692005367 DNA primase; Validated; Region: dnaG; PRK05667 66692005368 CHC2 zinc finger; Region: zf-CHC2; pfam01807 66692005369 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 66692005370 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 66692005371 active site 66692005372 metal binding site [ion binding]; metal-binding site 66692005373 interdomain interaction site; other site 66692005374 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 66692005375 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 66692005376 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 66692005377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 66692005378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692005379 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 66692005380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692005381 DNA binding residues [nucleotide binding] 66692005382 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 66692005383 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 66692005384 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 66692005385 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 66692005386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 66692005387 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 66692005388 Fe-S cluster binding site [ion binding]; other site 66692005389 substrate binding site [chemical binding]; other site 66692005390 catalytic site [active] 66692005391 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 66692005392 YqfQ-like protein; Region: YqfQ; pfam14181 66692005393 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 66692005394 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 66692005395 ATP binding site [chemical binding]; other site 66692005396 Mg++ binding site [ion binding]; other site 66692005397 motif III; other site 66692005398 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692005399 nucleotide binding region [chemical binding]; other site 66692005400 ATP-binding site [chemical binding]; other site 66692005401 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 66692005402 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 66692005403 AP (apurinic/apyrimidinic) site pocket; other site 66692005404 DNA interaction; other site 66692005405 Metal-binding active site; metal-binding site 66692005406 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 66692005407 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692005408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692005409 dimer interface [polypeptide binding]; other site 66692005410 phosphorylation site [posttranslational modification] 66692005411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692005412 ATP binding site [chemical binding]; other site 66692005413 Mg2+ binding site [ion binding]; other site 66692005414 G-X-G motif; other site 66692005415 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 66692005416 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 66692005417 N-acetyl-D-glucosamine binding site [chemical binding]; other site 66692005418 catalytic residue [active] 66692005419 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 66692005420 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 66692005421 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692005422 ABC-ATPase subunit interface; other site 66692005423 dimer interface [polypeptide binding]; other site 66692005424 putative PBP binding regions; other site 66692005425 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 66692005426 metal binding site 2 [ion binding]; metal-binding site 66692005427 putative DNA binding helix; other site 66692005428 metal binding site 1 [ion binding]; metal-binding site 66692005429 dimer interface [polypeptide binding]; other site 66692005430 structural Zn2+ binding site [ion binding]; other site 66692005431 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 66692005432 Uncharacterized conserved protein [Function unknown]; Region: COG5663 66692005433 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 66692005434 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 66692005435 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 66692005436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692005437 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692005438 putative substrate translocation pore; other site 66692005439 Protein of unknown function (DUF1002); Region: DUF1002; cl19854 66692005440 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 66692005441 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 66692005442 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 66692005443 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 66692005444 PhoU domain; Region: PhoU; pfam01895 66692005445 PhoU domain; Region: PhoU; pfam01895 66692005446 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 66692005447 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 66692005448 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 66692005449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692005450 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692005451 putative substrate translocation pore; other site 66692005452 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 66692005453 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 66692005454 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 66692005455 proteins similar to Escherichia coli yceG; Region: yceG_like; cl18961 66692005456 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 66692005457 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 66692005458 Integral membrane protein DUF92; Region: DUF92; pfam01940 66692005459 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 66692005460 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 66692005461 ATP binding site [chemical binding]; other site 66692005462 substrate interface [chemical binding]; other site 66692005463 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 66692005464 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692005465 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 66692005466 Rhomboid family; Region: Rhomboid; pfam01694 66692005467 TPR repeat; Region: TPR_11; pfam13414 66692005468 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692005469 TPR motif; other site 66692005470 binding surface 66692005471 Tetratricopeptide repeat; Region: TPR_16; pfam13432 66692005472 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692005473 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 66692005474 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 66692005475 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 66692005476 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692005477 nucleotide binding site [chemical binding]; other site 66692005478 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 66692005479 Aspartase; Region: Aspartase; cd01357 66692005480 active sites [active] 66692005481 tetramer interface [polypeptide binding]; other site 66692005482 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 66692005483 thiamine phosphate binding site [chemical binding]; other site 66692005484 active site 66692005485 pyrophosphate binding site [ion binding]; other site 66692005486 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 66692005487 thiS-thiF/thiG interaction site; other site 66692005488 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 66692005489 ThiS interaction site; other site 66692005490 putative active site [active] 66692005491 tetramer interface [polypeptide binding]; other site 66692005492 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 66692005493 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 66692005494 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 66692005495 dimer interface [polypeptide binding]; other site 66692005496 substrate binding site [chemical binding]; other site 66692005497 ATP binding site [chemical binding]; other site 66692005498 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 66692005499 Domain of unknown function DUF77; Region: DUF77; pfam01910 66692005500 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 66692005501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692005502 Coenzyme A binding pocket [chemical binding]; other site 66692005503 hypothetical protein; Provisional; Region: PRK13679 66692005504 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 66692005505 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 66692005506 Putative esterase; Region: Esterase; pfam00756 66692005507 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692005508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692005509 non-specific DNA binding site [nucleotide binding]; other site 66692005510 salt bridge; other site 66692005511 sequence-specific DNA binding site [nucleotide binding]; other site 66692005512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692005513 non-specific DNA binding site [nucleotide binding]; other site 66692005514 salt bridge; other site 66692005515 sequence-specific DNA binding site [nucleotide binding]; other site 66692005516 fumarate hydratase; Reviewed; Region: fumC; PRK00485 66692005517 Class II fumarases; Region: Fumarase_classII; cd01362 66692005518 active site 66692005519 tetramer interface [polypeptide binding]; other site 66692005520 methionine sulfoxide reductase B; Provisional; Region: PRK00222 66692005521 methionine sulfoxide reductase A; Provisional; Region: PRK14054 66692005522 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 66692005523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692005524 dimer interface [polypeptide binding]; other site 66692005525 phosphorylation site [posttranslational modification] 66692005526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692005527 ATP binding site [chemical binding]; other site 66692005528 Mg2+ binding site [ion binding]; other site 66692005529 G-X-G motif; other site 66692005530 Predicted membrane protein [Function unknown]; Region: COG4129 66692005531 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 66692005532 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 66692005533 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 66692005534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 66692005535 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 66692005536 dimer interface [polypeptide binding]; other site 66692005537 substrate binding site [chemical binding]; other site 66692005538 metal binding site [ion binding]; metal-binding site 66692005539 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 66692005540 peptidase T-like protein; Region: PepT-like; TIGR01883 66692005541 metal binding site [ion binding]; metal-binding site 66692005542 putative dimer interface [polypeptide binding]; other site 66692005543 Protein of unknown function (DUF327); Region: DUF327; pfam03885 66692005544 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 66692005545 hydrophobic ligand binding site; other site 66692005546 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 66692005547 FOG: CBS domain [General function prediction only]; Region: COG0517 66692005548 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 66692005549 Subtilase family; Region: Peptidase_S8; pfam00082 66692005550 active site 66692005551 catalytic triad [active] 66692005552 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 66692005553 NodB motif; other site 66692005554 putative active site [active] 66692005555 putative catalytic site [active] 66692005556 Zn binding site [ion binding]; other site 66692005557 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 66692005558 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692005559 DNA binding residues [nucleotide binding] 66692005560 aspartate kinase; Reviewed; Region: PRK09034 66692005561 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 66692005562 putative catalytic residues [active] 66692005563 putative nucleotide binding site [chemical binding]; other site 66692005564 putative aspartate binding site [chemical binding]; other site 66692005565 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 66692005566 allosteric regulatory residue; other site 66692005567 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 66692005568 Ion transport protein; Region: Ion_trans; pfam00520 66692005569 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 66692005570 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 66692005571 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 66692005572 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 66692005573 putative catalytic cysteine [active] 66692005574 gamma-glutamyl kinase; Provisional; Region: PRK05429 66692005575 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 66692005576 nucleotide binding site [chemical binding]; other site 66692005577 homotetrameric interface [polypeptide binding]; other site 66692005578 putative phosphate binding site [ion binding]; other site 66692005579 putative allosteric binding site; other site 66692005580 PUA domain; Region: PUA; pfam01472 66692005581 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 66692005582 active site 66692005583 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 66692005584 dimer interface [polypeptide binding]; other site 66692005585 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 66692005586 Ligand Binding Site [chemical binding]; other site 66692005587 Molecular Tunnel; other site 66692005588 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 66692005589 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692005590 VanZ like family; Region: VanZ; pfam04892 66692005591 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 66692005592 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 66692005593 DNA binding site [nucleotide binding] 66692005594 active site 66692005595 Predicted transcriptional regulators [Transcription]; Region: COG1510 66692005596 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 66692005597 HPr interaction site; other site 66692005598 glycerol kinase (GK) interaction site [polypeptide binding]; other site 66692005599 active site 66692005600 phosphorylation site [posttranslational modification] 66692005601 hypothetical protein; Provisional; Region: PRK04164 66692005602 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 66692005603 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 66692005604 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 66692005605 dimer interface [polypeptide binding]; other site 66692005606 catalytic residue [active] 66692005607 metal binding site [ion binding]; metal-binding site 66692005608 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 66692005609 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 66692005610 catalytic residues [active] 66692005611 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 66692005612 dimer interface [polypeptide binding]; other site 66692005613 ADP-ribose binding site [chemical binding]; other site 66692005614 active site 66692005615 nudix motif; other site 66692005616 metal binding site [ion binding]; metal-binding site 66692005617 stage II sporulation protein M; Region: spo_II_M; TIGR02831 66692005618 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 66692005619 metal binding site 2 [ion binding]; metal-binding site 66692005620 putative DNA binding helix; other site 66692005621 metal binding site 1 [ion binding]; metal-binding site 66692005622 dimer interface [polypeptide binding]; other site 66692005623 structural Zn2+ binding site [ion binding]; other site 66692005624 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 66692005625 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 66692005626 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 66692005627 active site 66692005628 Int/Topo IB signature motif; other site 66692005629 phosphopentomutase; Provisional; Region: PRK05362 66692005630 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 66692005631 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 66692005632 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 66692005633 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 66692005634 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 66692005635 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 66692005636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692005637 putative substrate translocation pore; other site 66692005638 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 66692005639 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 66692005640 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 66692005641 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 66692005642 NodB motif; other site 66692005643 active site 66692005644 catalytic site [active] 66692005645 metal binding site [ion binding]; metal-binding site 66692005646 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 66692005647 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 66692005648 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 66692005649 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 66692005650 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692005651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692005652 ATP binding site [chemical binding]; other site 66692005653 Mg2+ binding site [ion binding]; other site 66692005654 G-X-G motif; other site 66692005655 sporulation sigma factor SigF; Validated; Region: PRK05572 66692005656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692005657 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 66692005658 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692005659 DNA binding residues [nucleotide binding] 66692005660 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 66692005661 stage V sporulation protein AD; Validated; Region: PRK08304 66692005662 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 66692005663 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 66692005664 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 66692005665 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692005666 diaminopimelate decarboxylase; Region: lysA; TIGR01048 66692005667 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 66692005668 active site 66692005669 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 66692005670 substrate binding site [chemical binding]; other site 66692005671 catalytic residues [active] 66692005672 dimer interface [polypeptide binding]; other site 66692005673 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 66692005674 active site 66692005675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692005676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692005677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692005678 dimerization interface [polypeptide binding]; other site 66692005679 Protein of unknown function (DUF3810); Region: DUF3810; pfam12725 66692005680 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 66692005681 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 66692005682 dimer interface [polypeptide binding]; other site 66692005683 active site 66692005684 coenzyme A binding site [chemical binding]; other site 66692005685 citrylCoA binding site [chemical binding]; other site 66692005686 oxalacetate/citrate binding site [chemical binding]; other site 66692005687 catalytic triad [active] 66692005688 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 66692005689 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 66692005690 tetramer interface [polypeptide binding]; other site 66692005691 active site 66692005692 Mg2+/Mn2+ binding site [ion binding]; other site 66692005693 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 66692005694 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 66692005695 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 66692005696 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 66692005697 tetrameric interface [polypeptide binding]; other site 66692005698 NAD binding site [chemical binding]; other site 66692005699 catalytic residues [active] 66692005700 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 66692005701 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 66692005702 substrate binding site [chemical binding]; other site 66692005703 oxyanion hole (OAH) forming residues; other site 66692005704 trimer interface [polypeptide binding]; other site 66692005705 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 66692005706 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 66692005707 Lumazine binding domain; Region: Lum_binding; pfam00677 66692005708 Lumazine binding domain; Region: Lum_binding; pfam00677 66692005709 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 66692005710 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 66692005711 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 66692005712 dimerization interface [polypeptide binding]; other site 66692005713 active site 66692005714 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 66692005715 homopentamer interface [polypeptide binding]; other site 66692005716 active site 66692005717 Domain of unknown function (DUF309); Region: DUF309; pfam03745 66692005718 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 66692005719 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 66692005720 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692005721 putative DNA binding site [nucleotide binding]; other site 66692005722 dimerization interface [polypeptide binding]; other site 66692005723 putative Zn2+ binding site [ion binding]; other site 66692005724 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 66692005725 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 66692005726 NAD(P) binding site [chemical binding]; other site 66692005727 catalytic residues [active] 66692005728 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 66692005729 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 66692005730 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 66692005731 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 66692005732 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 66692005733 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 66692005734 putative active site [active] 66692005735 catalytic site [active] 66692005736 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 66692005737 putative active site [active] 66692005738 catalytic site [active] 66692005739 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 66692005740 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 66692005741 active site 66692005742 ATP binding site [chemical binding]; other site 66692005743 Uncharacterized conserved protein [Function unknown]; Region: COG3937 66692005744 Predicted membrane protein [Function unknown]; Region: COG2323 66692005745 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 66692005746 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 66692005747 stage V sporulation protein AD; Provisional; Region: PRK12404 66692005748 stage V sporulation protein AD; Region: spore_V_AD; TIGR02845 66692005749 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 66692005750 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 66692005751 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl19191 66692005752 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 66692005753 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 66692005754 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 66692005755 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 66692005756 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692005757 RNA binding surface [nucleotide binding]; other site 66692005758 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 66692005759 active site 66692005760 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 66692005761 catalytic residues [active] 66692005762 ResB-like family; Region: ResB; pfam05140 66692005763 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 66692005764 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692005765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692005766 active site 66692005767 phosphorylation site [posttranslational modification] 66692005768 intermolecular recognition site; other site 66692005769 dimerization interface [polypeptide binding]; other site 66692005770 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692005771 DNA binding site [nucleotide binding] 66692005772 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 66692005773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692005774 dimerization interface [polypeptide binding]; other site 66692005775 PAS domain; Region: PAS; smart00091 66692005776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692005777 dimer interface [polypeptide binding]; other site 66692005778 phosphorylation site [posttranslational modification] 66692005779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692005780 ATP binding site [chemical binding]; other site 66692005781 Mg2+ binding site [ion binding]; other site 66692005782 G-X-G motif; other site 66692005783 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692005784 ABC-ATPase subunit interface; other site 66692005785 dimer interface [polypeptide binding]; other site 66692005786 putative PBP binding regions; other site 66692005787 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 66692005788 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 66692005789 Walker A/P-loop; other site 66692005790 ATP binding site [chemical binding]; other site 66692005791 Q-loop/lid; other site 66692005792 ABC transporter signature motif; other site 66692005793 Walker B; other site 66692005794 D-loop; other site 66692005795 H-loop/switch region; other site 66692005796 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 66692005797 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 66692005798 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 66692005799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692005800 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 66692005801 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 66692005802 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 66692005803 ligand binding site [chemical binding]; other site 66692005804 NAD binding site [chemical binding]; other site 66692005805 dimerization interface [polypeptide binding]; other site 66692005806 catalytic site [active] 66692005807 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 66692005808 putative L-serine binding site [chemical binding]; other site 66692005809 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 66692005810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 66692005811 RQC domain; Region: RQC; cl09632 66692005812 Helix-turn-helix domain; Region: HTH_40; pfam14493 66692005813 DEAD-like helicases superfamily; Region: DEXDc; smart00487 66692005814 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692005815 ATP binding site [chemical binding]; other site 66692005816 putative Mg++ binding site [ion binding]; other site 66692005817 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692005818 nucleotide binding region [chemical binding]; other site 66692005819 ATP-binding site [chemical binding]; other site 66692005820 CAAX protease self-immunity; Region: Abi; pfam02517 66692005821 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 66692005822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692005823 non-specific DNA binding site [nucleotide binding]; other site 66692005824 salt bridge; other site 66692005825 sequence-specific DNA binding site [nucleotide binding]; other site 66692005826 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692005827 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692005828 non-specific DNA binding site [nucleotide binding]; other site 66692005829 salt bridge; other site 66692005830 sequence-specific DNA binding site [nucleotide binding]; other site 66692005831 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692005832 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 66692005833 putative ADP-binding pocket [chemical binding]; other site 66692005834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692005835 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 66692005836 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 66692005837 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692005838 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 66692005839 metal binding site [ion binding]; metal-binding site 66692005840 dimer interface [polypeptide binding]; other site 66692005841 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 66692005842 putative active site [active] 66692005843 putative metal binding site [ion binding]; other site 66692005844 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692005845 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 66692005846 DNA binding residues [nucleotide binding] 66692005847 B12 binding domain; Region: B12-binding_2; pfam02607 66692005848 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 66692005849 adaptor protein; Provisional; Region: PRK02899 66692005850 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692005851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692005852 active site 66692005853 phosphorylation site [posttranslational modification] 66692005854 intermolecular recognition site; other site 66692005855 dimerization interface [polypeptide binding]; other site 66692005856 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692005857 DNA binding site [nucleotide binding] 66692005858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692005859 HAMP domain; Region: HAMP; pfam00672 66692005860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692005861 dimer interface [polypeptide binding]; other site 66692005862 phosphorylation site [posttranslational modification] 66692005863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692005864 ATP binding site [chemical binding]; other site 66692005865 Mg2+ binding site [ion binding]; other site 66692005866 G-X-G motif; other site 66692005867 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 66692005868 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 66692005869 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 66692005870 NAD(P) binding site [chemical binding]; other site 66692005871 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 66692005872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 66692005873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692005874 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 66692005875 active site 66692005876 homotetramer interface [polypeptide binding]; other site 66692005877 homodimer interface [polypeptide binding]; other site 66692005878 Protease prsW family; Region: PrsW-protease; pfam13367 66692005879 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 66692005880 homodimer interface [polypeptide binding]; other site 66692005881 substrate-cofactor binding pocket; other site 66692005882 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692005883 catalytic residue [active] 66692005884 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 66692005885 Homocysteine S-methyltransferase; Region: S-methyl_trans; cl14105 66692005886 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 66692005887 FAD binding site [chemical binding]; other site 66692005888 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 66692005889 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 66692005890 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 66692005891 substrate binding pocket [chemical binding]; other site 66692005892 dimer interface [polypeptide binding]; other site 66692005893 inhibitor binding site; inhibition site 66692005894 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 66692005895 B12 binding site [chemical binding]; other site 66692005896 cobalt ligand [ion binding]; other site 66692005897 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 66692005898 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 66692005899 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692005900 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 66692005901 germination protein YpeB; Region: spore_YpeB; TIGR02889 66692005902 YpeB sporulation; Region: YPEB; pfam14620 66692005903 cytidylate kinase; Provisional; Region: cmk; PRK00023 66692005904 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 66692005905 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 66692005906 active site 66692005907 CMP-binding site; other site 66692005908 The sites determining sugar specificity; other site 66692005909 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 66692005910 putative acyl-acceptor binding pocket; other site 66692005911 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 66692005912 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 66692005913 RNA binding site [nucleotide binding]; other site 66692005914 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 66692005915 RNA binding site [nucleotide binding]; other site 66692005916 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 66692005917 RNA binding site [nucleotide binding]; other site 66692005918 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 66692005919 RNA binding site [nucleotide binding]; other site 66692005920 GTP-binding protein Der; Reviewed; Region: PRK00093 66692005921 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 66692005922 G1 box; other site 66692005923 GTP/Mg2+ binding site [chemical binding]; other site 66692005924 Switch I region; other site 66692005925 G2 box; other site 66692005926 Switch II region; other site 66692005927 G3 box; other site 66692005928 G4 box; other site 66692005929 G5 box; other site 66692005930 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 66692005931 G1 box; other site 66692005932 GTP/Mg2+ binding site [chemical binding]; other site 66692005933 Switch I region; other site 66692005934 G2 box; other site 66692005935 G3 box; other site 66692005936 Switch II region; other site 66692005937 G4 box; other site 66692005938 G5 box; other site 66692005939 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 66692005940 membrane protein; Provisional; Region: PRK14405 66692005941 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 66692005942 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 66692005943 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 66692005944 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 66692005945 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 66692005946 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 66692005947 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 66692005948 active site 66692005949 transcription attenuation protein MtrB; Provisional; Region: PRK13251 66692005950 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 66692005951 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 66692005952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692005953 S-adenosylmethionine binding site [chemical binding]; other site 66692005954 4-Hydroxybenzoate polyprenyltransferase; Region: PT_UbiA_COQ2; cd13959 66692005955 putative active site [active] 66692005956 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 66692005957 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 66692005958 substrate binding pocket [chemical binding]; other site 66692005959 chain length determination region; other site 66692005960 substrate-Mg2+ binding site; other site 66692005961 catalytic residues [active] 66692005962 aspartate-rich region 1; other site 66692005963 active site lid residues [active] 66692005964 aspartate-rich region 2; other site 66692005965 Nucleoside diphosphate kinase; Region: NDK; pfam00334 66692005966 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 66692005967 active site 66692005968 multimer interface [polypeptide binding]; other site 66692005969 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 66692005970 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 66692005971 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 66692005972 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 66692005973 Tetramer interface [polypeptide binding]; other site 66692005974 active site 66692005975 FMN-binding site [chemical binding]; other site 66692005976 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 66692005977 active site 66692005978 dimer interface [polypeptide binding]; other site 66692005979 metal binding site [ion binding]; metal-binding site 66692005980 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 66692005981 homotrimer interaction site [polypeptide binding]; other site 66692005982 active site 66692005983 anthranilate synthase component I; Provisional; Region: PRK13569 66692005984 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 66692005985 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 66692005986 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 66692005987 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 66692005988 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 66692005989 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 66692005990 active site 66692005991 ribulose/triose binding site [chemical binding]; other site 66692005992 phosphate binding site [ion binding]; other site 66692005993 substrate (anthranilate) binding pocket [chemical binding]; other site 66692005994 product (indole) binding pocket [chemical binding]; other site 66692005995 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 66692005996 active site 66692005997 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 66692005998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692005999 catalytic residue [active] 66692006000 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 66692006001 substrate binding site [chemical binding]; other site 66692006002 active site 66692006003 catalytic residues [active] 66692006004 heterodimer interface [polypeptide binding]; other site 66692006005 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 66692006006 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692006007 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692006008 homodimer interface [polypeptide binding]; other site 66692006009 catalytic residue [active] 66692006010 prephenate dehydrogenase; Validated; Region: PRK08507 66692006011 prephenate dehydrogenase; Validated; Region: PRK06545 66692006012 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 66692006013 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 66692006014 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 66692006015 hinge; other site 66692006016 active site 66692006017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692006018 binding surface 66692006019 Tetratricopeptide repeat; Region: TPR_16; pfam13432 66692006020 TPR motif; other site 66692006021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692006022 binding surface 66692006023 TPR motif; other site 66692006024 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 66692006025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692006026 binding surface 66692006027 TPR motif; other site 66692006028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692006029 TPR motif; other site 66692006030 binding surface 66692006031 hypothetical protein; Provisional; Region: PRK03636 66692006032 UPF0302 domain; Region: UPF0302; pfam08864 66692006033 IDEAL domain; Region: IDEAL; pfam08858 66692006034 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 66692006035 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 66692006036 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 66692006037 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 66692006038 iron-sulfur cluster [ion binding]; other site 66692006039 [2Fe-2S] cluster binding site [ion binding]; other site 66692006040 cytochrome b6; Provisional; Region: PRK03735 66692006041 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 66692006042 interchain domain interface [polypeptide binding]; other site 66692006043 intrachain domain interface; other site 66692006044 heme bH binding site [chemical binding]; other site 66692006045 Qi binding site; other site 66692006046 heme bL binding site [chemical binding]; other site 66692006047 Qo binding site; other site 66692006048 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 66692006049 interchain domain interface [polypeptide binding]; other site 66692006050 intrachain domain interface; other site 66692006051 Qi binding site; other site 66692006052 Qo binding site; other site 66692006053 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 66692006054 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 66692006055 Protein of unknown function (DUF1405); Region: DUF1405; pfam07187 66692006056 sporulation protein YpjB; Region: spore_ypjB; TIGR02878 66692006057 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 66692006058 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 66692006059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692006060 putative substrate translocation pore; other site 66692006061 Uncharacterized conserved protein [Function unknown]; Region: COG1284 66692006062 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692006063 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692006064 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 66692006065 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 66692006066 homodimer interface [polypeptide binding]; other site 66692006067 metal binding site [ion binding]; metal-binding site 66692006068 dihydrodipicolinate reductase; Provisional; Region: PRK00048 66692006069 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 66692006070 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 66692006071 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 66692006072 active site 66692006073 dimer interfaces [polypeptide binding]; other site 66692006074 catalytic residues [active] 66692006075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692006076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692006077 Coenzyme A binding pocket [chemical binding]; other site 66692006078 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 66692006079 tRNA-splicing ligase RtcB; Region: RtcB; pfam01139 66692006080 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 66692006081 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692006082 Coenzyme A binding pocket [chemical binding]; other site 66692006083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 66692006084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692006085 S-adenosylmethionine binding site [chemical binding]; other site 66692006086 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 66692006087 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 66692006088 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 66692006089 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 66692006090 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 66692006091 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 66692006092 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 66692006093 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692006094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692006095 S-adenosylmethionine binding site [chemical binding]; other site 66692006096 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 66692006097 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692006098 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692006099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 66692006100 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692006101 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692006102 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 66692006103 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 66692006104 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 66692006105 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 66692006106 homodimer interface [polypeptide binding]; other site 66692006107 substrate-cofactor binding pocket; other site 66692006108 catalytic residue [active] 66692006109 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 66692006110 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692006111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692006112 active site 66692006113 motif I; other site 66692006114 motif II; other site 66692006115 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 66692006116 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 66692006117 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 66692006118 Walker A/P-loop; other site 66692006119 ATP binding site [chemical binding]; other site 66692006120 Q-loop/lid; other site 66692006121 ABC transporter signature motif; other site 66692006122 Walker B; other site 66692006123 D-loop; other site 66692006124 H-loop/switch region; other site 66692006125 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 66692006126 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 66692006127 Walker A/P-loop; other site 66692006128 ATP binding site [chemical binding]; other site 66692006129 Q-loop/lid; other site 66692006130 ABC transporter signature motif; other site 66692006131 Walker B; other site 66692006132 D-loop; other site 66692006133 H-loop/switch region; other site 66692006134 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 66692006135 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 66692006136 active site 66692006137 DNA binding site [nucleotide binding] 66692006138 DNA protecting protein DprA; Region: dprA; TIGR00732 66692006139 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 66692006140 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692006141 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 66692006142 NlpC/P60 family; Region: NLPC_P60; pfam00877 66692006143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 66692006144 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 66692006145 Sterol carrier protein domain; Region: SCP2_2; pfam13530 66692006146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692006147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692006148 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 66692006149 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 66692006150 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 66692006151 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 66692006152 cysteine synthase; Region: PLN02565 66692006153 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 66692006154 dimer interface [polypeptide binding]; other site 66692006155 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692006156 catalytic residue [active] 66692006157 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 66692006158 homodimer interface [polypeptide binding]; other site 66692006159 substrate-cofactor binding pocket; other site 66692006160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692006161 catalytic residue [active] 66692006162 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 66692006163 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 66692006164 IucA / IucC family; Region: IucA_IucC; pfam04183 66692006165 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 66692006166 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 66692006167 IucA / IucC family; Region: IucA_IucC; pfam04183 66692006168 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 66692006169 acyl-CoA synthetase; Validated; Region: PRK08308 66692006170 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 66692006171 acyl-activating enzyme (AAE) consensus motif; other site 66692006172 AMP binding site [chemical binding]; other site 66692006173 active site 66692006174 CoA binding site [chemical binding]; other site 66692006175 acyl carrier protein; Provisional; Region: PRK07639 66692006176 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692006177 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692006178 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 66692006179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692006180 active site 66692006181 motif I; other site 66692006182 motif II; other site 66692006183 D-serine dehydratase; Provisional; Region: PRK02991 66692006184 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692006185 catalytic residue [active] 66692006186 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 66692006187 active site 66692006188 putative catalytic site [active] 66692006189 DNA binding site [nucleotide binding] 66692006190 putative phosphate binding site [ion binding]; other site 66692006191 metal binding site A [ion binding]; metal-binding site 66692006192 AP binding site [nucleotide binding]; other site 66692006193 metal binding site B [ion binding]; metal-binding site 66692006194 hypothetical protein; Provisional; Region: PRK12378 66692006195 EamA-like transporter family; Region: EamA; pfam00892 66692006196 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 66692006197 EamA-like transporter family; Region: EamA; pfam00892 66692006198 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 66692006199 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 66692006200 Na2 binding site [ion binding]; other site 66692006201 putative substrate binding site 1 [chemical binding]; other site 66692006202 Na binding site 1 [ion binding]; other site 66692006203 putative substrate binding site 2 [chemical binding]; other site 66692006204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692006205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692006206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692006207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 66692006208 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692006209 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 66692006210 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 66692006211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692006212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692006213 putative substrate translocation pore; other site 66692006214 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 66692006215 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 66692006216 active site 66692006217 NTP binding site [chemical binding]; other site 66692006218 metal binding triad [ion binding]; metal-binding site 66692006219 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 66692006220 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 66692006221 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692006222 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692006223 Walker A/P-loop; other site 66692006224 ATP binding site [chemical binding]; other site 66692006225 Q-loop/lid; other site 66692006226 ABC transporter signature motif; other site 66692006227 Walker B; other site 66692006228 D-loop; other site 66692006229 H-loop/switch region; other site 66692006230 Acyltransferase family; Region: Acyl_transf_3; cl19154 66692006231 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 66692006232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692006233 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692006234 DNA binding residues [nucleotide binding] 66692006235 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 66692006236 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692006237 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692006238 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692006239 Bacterial PH domain; Region: bPH_4; pfam06713 66692006240 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 66692006241 HEAT repeats; Region: HEAT_2; pfam13646 66692006242 Chloramphenicol acetyltransferase; Region: CAT; cl02008 66692006243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 66692006244 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 66692006245 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 66692006246 hypothetical protein; Provisional; Region: PRK07758 66692006247 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 66692006248 Uncharacterized conserved protein [Function unknown]; Region: COG1284 66692006249 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692006250 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 66692006251 flagellar motor protein MotA; Validated; Region: PRK08124 66692006252 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 66692006253 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 66692006254 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 66692006255 ligand binding site [chemical binding]; other site 66692006256 Domain of unknown function DUF20; Region: UPF0118; cl00465 66692006257 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 66692006258 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 66692006259 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 66692006260 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 66692006261 CAP-like domain; other site 66692006262 active site 66692006263 primary dimer interface [polypeptide binding]; other site 66692006264 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692006265 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692006266 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 66692006267 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 66692006268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692006269 ATP binding site [chemical binding]; other site 66692006270 Mg2+ binding site [ion binding]; other site 66692006271 G-X-G motif; other site 66692006272 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 66692006273 anchoring element; other site 66692006274 dimer interface [polypeptide binding]; other site 66692006275 ATP binding site [chemical binding]; other site 66692006276 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 66692006277 active site 66692006278 metal binding site [ion binding]; metal-binding site 66692006279 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 66692006280 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 66692006281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692006282 dimer interface [polypeptide binding]; other site 66692006283 conserved gate region; other site 66692006284 ABC-ATPase subunit interface; other site 66692006285 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 66692006286 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 66692006287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692006288 Walker A/P-loop; other site 66692006289 ATP binding site [chemical binding]; other site 66692006290 Q-loop/lid; other site 66692006291 ABC transporter signature motif; other site 66692006292 Walker B; other site 66692006293 D-loop; other site 66692006294 H-loop/switch region; other site 66692006295 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 66692006296 short chain dehydrogenase; Provisional; Region: PRK07677 66692006297 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 66692006298 NAD(P) binding site [chemical binding]; other site 66692006299 substrate binding site [chemical binding]; other site 66692006300 homotetramer interface [polypeptide binding]; other site 66692006301 active site 66692006302 homodimer interface [polypeptide binding]; other site 66692006303 MarC family integral membrane protein; Region: MarC; cl00919 66692006304 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 66692006305 active site 66692006306 Zn binding site [ion binding]; other site 66692006307 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 66692006308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692006309 S-adenosylmethionine binding site [chemical binding]; other site 66692006310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692006311 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692006312 putative substrate translocation pore; other site 66692006313 Protein of unknown function (DUF2564); Region: DUF2564; pfam10819 66692006314 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 66692006315 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 66692006316 N- and C-terminal domain interface [polypeptide binding]; other site 66692006317 active site 66692006318 catalytic site [active] 66692006319 metal binding site [ion binding]; metal-binding site 66692006320 carbohydrate binding site [chemical binding]; other site 66692006321 ATP binding site [chemical binding]; other site 66692006322 Variant SH3 domain; Region: SH3_2; pfam07653 66692006323 Src Homology 3 domain superfamily; Region: SH3; cd00174 66692006324 peptide ligand binding site [polypeptide binding]; other site 66692006325 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692006326 Spore germination protein; Region: Spore_permease; cl17796 66692006327 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 66692006328 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692006329 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 66692006330 dimer interface [polypeptide binding]; other site 66692006331 putative CheW interface [polypeptide binding]; other site 66692006332 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 66692006333 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 66692006334 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 66692006335 PYR/PP interface [polypeptide binding]; other site 66692006336 dimer interface [polypeptide binding]; other site 66692006337 TPP binding site [chemical binding]; other site 66692006338 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 66692006339 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 66692006340 TPP-binding site [chemical binding]; other site 66692006341 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692006342 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692006343 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692006344 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 66692006345 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 66692006346 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 66692006347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 66692006348 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 66692006349 Probable transposase; Region: OrfB_IS605; pfam01385 66692006350 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 66692006351 RNAse HI family that includes archaeal, some bacterial as well as plant RNase HI; Region: RNase_HI_like; cd09279 66692006352 RNA/DNA hybrid binding site [nucleotide binding]; other site 66692006353 active site 66692006354 cell division protein GpsB; Provisional; Region: PRK14127 66692006355 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 66692006356 hypothetical protein; Provisional; Region: PRK13660 66692006357 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 66692006358 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 66692006359 RNase_H superfamily; Region: RNase_H_2; pfam13482 66692006360 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 66692006361 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 66692006362 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692006363 ATP binding site [chemical binding]; other site 66692006364 putative Mg++ binding site [ion binding]; other site 66692006365 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692006366 nucleotide binding region [chemical binding]; other site 66692006367 ATP-binding site [chemical binding]; other site 66692006368 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 66692006369 oligoendopeptidase F; Region: pepF; TIGR00181 66692006370 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 66692006371 active site 66692006372 Zn binding site [ion binding]; other site 66692006373 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692006374 Spore germination protein; Region: Spore_permease; cl17796 66692006375 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 66692006376 hypothetical protein; Validated; Region: PRK07668 66692006377 Predicted esterase [General function prediction only]; Region: COG0400 66692006378 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692006379 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 66692006380 Zn binding site [ion binding]; other site 66692006381 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 66692006382 Zn binding site [ion binding]; other site 66692006383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692006384 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 66692006385 active site 66692006386 motif I; other site 66692006387 motif II; other site 66692006388 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692006389 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 66692006390 dimer interface [polypeptide binding]; other site 66692006391 active site 66692006392 catalytic residue [active] 66692006393 Kinase associated protein B; Region: KapB; pfam08810 66692006394 YpjP-like protein; Region: YpjP; pfam14005 66692006395 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 66692006396 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 66692006397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692006398 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 66692006399 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 66692006400 active site 66692006401 dimer interface [polypeptide binding]; other site 66692006402 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 66692006403 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 66692006404 active site 66692006405 FMN binding site [chemical binding]; other site 66692006406 substrate binding site [chemical binding]; other site 66692006407 3Fe-4S cluster binding site [ion binding]; other site 66692006408 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 66692006409 domain interface; other site 66692006410 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 66692006411 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 66692006412 Predicted membrane protein [Function unknown]; Region: COG3428 66692006413 Bacterial PH domain; Region: bPH_2; pfam03703 66692006414 Bacterial PH domain; Region: bPH_2; pfam03703 66692006415 Bacterial PH domain; Region: bPH_2; pfam03703 66692006416 Uncharacterized conserved protein [Function unknown]; Region: COG3402 66692006417 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 66692006418 Virulence factor; Region: Virulence_fact; pfam13769 66692006419 HEAT repeats; Region: HEAT_2; pfam13646 66692006420 HEAT repeat; Region: HEAT; pfam02985 66692006421 HEAT repeats; Region: HEAT_2; pfam13646 66692006422 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 66692006423 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 66692006424 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 66692006425 active site 66692006426 metal binding site [ion binding]; metal-binding site 66692006427 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 66692006428 catalytic residues [active] 66692006429 Disulphide isomerase; Region: Disulph_isomer; pfam06491 66692006430 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 66692006431 catalytic residues [active] 66692006432 ribonuclease Z; Region: RNase_Z; TIGR02651 66692006433 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 66692006434 intracellular protease, PfpI family; Region: PfpI; TIGR01382 66692006435 proposed catalytic triad [active] 66692006436 conserved cys residue [active] 66692006437 threonine dehydratase; Validated; Region: PRK08639 66692006438 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 66692006439 tetramer interface [polypeptide binding]; other site 66692006440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692006441 catalytic residue [active] 66692006442 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 66692006443 putative Ile/Val binding site [chemical binding]; other site 66692006444 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 66692006445 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 66692006446 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 66692006447 DNA binding residues [nucleotide binding] 66692006448 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 66692006449 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 66692006450 Transglycosylase; Region: Transgly; pfam00912 66692006451 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 66692006452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 66692006453 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 66692006454 Interdomain contacts; other site 66692006455 Cytokine receptor motif; other site 66692006456 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 66692006457 G1 box; other site 66692006458 GTP/Mg2+ binding site [chemical binding]; other site 66692006459 G2 box; other site 66692006460 Switch I region; other site 66692006461 G3 box; other site 66692006462 Switch II region; other site 66692006463 G4 box; other site 66692006464 G5 box; other site 66692006465 Dynamin family; Region: Dynamin_N; pfam00350 66692006466 G1 box; other site 66692006467 GTP/Mg2+ binding site [chemical binding]; other site 66692006468 G2 box; other site 66692006469 Switch I region; other site 66692006470 G3 box; other site 66692006471 Switch II region; other site 66692006472 G4 box; other site 66692006473 G5 box; other site 66692006474 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 66692006475 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 66692006476 minor groove reading motif; other site 66692006477 helix-hairpin-helix signature motif; other site 66692006478 substrate binding pocket [chemical binding]; other site 66692006479 active site 66692006480 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 66692006481 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 66692006482 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 66692006483 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 66692006484 putative dimer interface [polypeptide binding]; other site 66692006485 putative anticodon binding site; other site 66692006486 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 66692006487 homodimer interface [polypeptide binding]; other site 66692006488 motif 1; other site 66692006489 motif 2; other site 66692006490 active site 66692006491 motif 3; other site 66692006492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 66692006493 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 66692006494 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 66692006495 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 66692006496 active site 66692006497 putative substrate binding pocket [chemical binding]; other site 66692006498 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 66692006499 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 66692006500 active site 66692006501 catalytic site [active] 66692006502 substrate binding site [chemical binding]; other site 66692006503 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cd09708 66692006504 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 66692006505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692006506 binding surface 66692006507 TPR motif; other site 66692006508 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 66692006509 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 66692006510 tetramerization interface [polypeptide binding]; other site 66692006511 active site 66692006512 Pantoate-beta-alanine ligase; Region: PanC; cd00560 66692006513 active site 66692006514 ATP-binding site [chemical binding]; other site 66692006515 pantoate-binding site; other site 66692006516 HXXH motif; other site 66692006517 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 66692006518 oligomerization interface [polypeptide binding]; other site 66692006519 active site 66692006520 metal binding site [ion binding]; metal-binding site 66692006521 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 66692006522 Biotin operon repressor [Transcription]; Region: BirA; COG1654 66692006523 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 66692006524 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 66692006525 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 66692006526 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 66692006527 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 66692006528 active site 66692006529 NTP binding site [chemical binding]; other site 66692006530 metal binding triad [ion binding]; metal-binding site 66692006531 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 66692006532 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 66692006533 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 66692006534 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 66692006535 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 66692006536 active site 66692006537 NTP binding site [chemical binding]; other site 66692006538 metal binding triad [ion binding]; metal-binding site 66692006539 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 66692006540 dimanganese center [ion binding]; other site 66692006541 Bacterial SH3 domain homologues; Region: SH3b; smart00287 66692006542 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692006543 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 66692006544 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 66692006545 active site 66692006546 metal binding site [ion binding]; metal-binding site 66692006547 CAAX protease self-immunity; Region: Abi; pfam02517 66692006548 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 66692006549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692006550 DNA-binding site [nucleotide binding]; DNA binding site 66692006551 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 66692006552 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 66692006553 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 66692006554 NAD binding site [chemical binding]; other site 66692006555 sugar binding site [chemical binding]; other site 66692006556 divalent metal binding site [ion binding]; other site 66692006557 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692006558 dimer interface [polypeptide binding]; other site 66692006559 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 66692006560 putative active site [active] 66692006561 YdjC motif; other site 66692006562 Mg binding site [ion binding]; other site 66692006563 putative homodimer interface [polypeptide binding]; other site 66692006564 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 66692006565 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692006566 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692006567 active site turn [active] 66692006568 phosphorylation site [posttranslational modification] 66692006569 hypothetical protein; Provisional; Region: PRK09272 66692006570 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692006571 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 66692006572 putative Zn2+ binding site [ion binding]; other site 66692006573 putative DNA binding site [nucleotide binding]; other site 66692006574 transcriptional regulator MurR; Provisional; Region: PRK15482 66692006575 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 66692006576 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692006577 putative active site [active] 66692006578 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 66692006579 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 66692006580 tetramer interface [polypeptide binding]; other site 66692006581 active site 66692006582 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 66692006583 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692006584 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692006585 active site turn [active] 66692006586 phosphorylation site [posttranslational modification] 66692006587 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 66692006588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692006589 active site 66692006590 motif I; other site 66692006591 motif II; other site 66692006592 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692006593 DinB superfamily; Region: DinB_2; pfam12867 66692006594 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 66692006595 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 66692006596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692006597 Nucleosome binding factor SPN, SPT16 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]; Region: COG5406 66692006598 hypothetical protein; Validated; Region: PRK07668 66692006599 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692006600 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 66692006601 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; cl09932 66692006602 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 66692006603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 66692006604 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 66692006605 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 66692006606 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 66692006607 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 66692006608 5'-3' exonuclease; Region: 53EXOc; smart00475 66692006609 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 66692006610 active site 66692006611 metal binding site 1 [ion binding]; metal-binding site 66692006612 putative 5' ssDNA interaction site; other site 66692006613 metal binding site 3; metal-binding site 66692006614 metal binding site 2 [ion binding]; metal-binding site 66692006615 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 66692006616 putative DNA binding site [nucleotide binding]; other site 66692006617 putative metal binding site [ion binding]; other site 66692006618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692006619 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 66692006620 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 66692006621 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 66692006622 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692006623 ATP binding site [chemical binding]; other site 66692006624 putative Mg++ binding site [ion binding]; other site 66692006625 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692006626 nucleotide binding region [chemical binding]; other site 66692006627 ATP-binding site [chemical binding]; other site 66692006628 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 66692006629 HRDC domain; Region: HRDC; pfam00570 66692006630 Helix-turn-helix domain; Region: HTH_40; pfam14493 66692006631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692006632 active site 66692006633 catalytic tetrad [active] 66692006634 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 66692006635 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692006636 ABC transporter; Region: ABC_tran_2; pfam12848 66692006637 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692006638 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 66692006639 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 66692006640 E3 interaction surface; other site 66692006641 lipoyl attachment site [posttranslational modification]; other site 66692006642 e3 binding domain; Region: E3_binding; pfam02817 66692006643 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 66692006644 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 66692006645 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 66692006646 TPP-binding site [chemical binding]; other site 66692006647 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 66692006648 dimer interface [polypeptide binding]; other site 66692006649 PYR/PP interface [polypeptide binding]; other site 66692006650 TPP binding site [chemical binding]; other site 66692006651 Transposase; Region: HTH_Tnp_1; cl17663 66692006652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692006653 S-adenosylmethionine binding site [chemical binding]; other site 66692006654 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 66692006655 N-acetyl-D-glucosamine binding site [chemical binding]; other site 66692006656 catalytic residue [active] 66692006657 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 66692006658 DNA topoisomerase III; Provisional; Region: PRK07726 66692006659 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 66692006660 active site 66692006661 putative interdomain interaction site [polypeptide binding]; other site 66692006662 putative metal-binding site [ion binding]; other site 66692006663 putative nucleotide binding site [chemical binding]; other site 66692006664 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 66692006665 domain I; other site 66692006666 DNA binding groove [nucleotide binding] 66692006667 phosphate binding site [ion binding]; other site 66692006668 domain II; other site 66692006669 domain III; other site 66692006670 nucleotide binding site [chemical binding]; other site 66692006671 catalytic site [active] 66692006672 domain IV; other site 66692006673 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 66692006674 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692006675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692006676 Walker A/P-loop; other site 66692006677 ATP binding site [chemical binding]; other site 66692006678 Q-loop/lid; other site 66692006679 ABC transporter signature motif; other site 66692006680 Walker B; other site 66692006681 D-loop; other site 66692006682 H-loop/switch region; other site 66692006683 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 66692006684 ABC-2 type transporter; Region: ABC2_membrane; cl17235 66692006685 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 66692006686 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692006687 Histidine kinase; Region: HisKA_3; pfam07730 66692006688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692006689 ATP binding site [chemical binding]; other site 66692006690 Mg2+ binding site [ion binding]; other site 66692006691 G-X-G motif; other site 66692006692 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692006693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692006694 active site 66692006695 phosphorylation site [posttranslational modification] 66692006696 intermolecular recognition site; other site 66692006697 dimerization interface [polypeptide binding]; other site 66692006698 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692006699 DNA binding residues [nucleotide binding] 66692006700 dimerization interface [polypeptide binding]; other site 66692006701 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 66692006702 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 66692006703 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692006704 FeS/SAM binding site; other site 66692006705 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 66692006706 active site 66692006707 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 66692006708 Ligand Binding Site [chemical binding]; other site 66692006709 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 66692006710 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 66692006711 Acylphosphatase; Region: Acylphosphatase; pfam00708 66692006712 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 66692006713 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 66692006714 Subunit I/III interface [polypeptide binding]; other site 66692006715 Subunit III/IV interface [polypeptide binding]; other site 66692006716 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 66692006717 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 66692006718 D-pathway; other site 66692006719 Putative ubiquinol binding site [chemical binding]; other site 66692006720 Low-spin heme (heme b) binding site [chemical binding]; other site 66692006721 Putative water exit pathway; other site 66692006722 Binuclear center (heme o3/CuB) [ion binding]; other site 66692006723 K-pathway; other site 66692006724 Putative proton exit pathway; other site 66692006725 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 66692006726 The cupredoxin domain of Ubiquinol oxidase subunit II; Region: CuRO_UO_II; cd04212 66692006727 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 66692006728 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692006729 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 66692006730 methionine sulfoxide reductase A; Provisional; Region: PRK14054 66692006731 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 66692006732 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 66692006733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692006734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692006735 active site 66692006736 phosphorylation site [posttranslational modification] 66692006737 intermolecular recognition site; other site 66692006738 dimerization interface [polypeptide binding]; other site 66692006739 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 66692006740 active site 66692006741 dimer interface [polypeptide binding]; other site 66692006742 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 66692006743 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 66692006744 putative dimer interface [polypeptide binding]; other site 66692006745 YppG-like protein; Region: YppG; pfam14179 66692006746 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 66692006747 EAL domain; Region: EAL; pfam00563 66692006748 EAL-domain associated signalling protein domain; Region: YkuI_C; pfam10388 66692006749 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692006750 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 66692006751 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 66692006752 proposed active site lysine [active] 66692006753 conserved cys residue [active] 66692006754 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 66692006755 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 66692006756 homodimer interface [polypeptide binding]; other site 66692006757 NAD binding pocket [chemical binding]; other site 66692006758 ATP binding pocket [chemical binding]; other site 66692006759 Mg binding site [ion binding]; other site 66692006760 active-site loop [active] 66692006761 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 66692006762 active site 66692006763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692006764 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 66692006765 Walker A motif; other site 66692006766 ATP binding site [chemical binding]; other site 66692006767 Walker B motif; other site 66692006768 arginine finger; other site 66692006769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692006770 Walker A motif; other site 66692006771 ATP binding site [chemical binding]; other site 66692006772 Walker B motif; other site 66692006773 arginine finger; other site 66692006774 Copper resistance protein D; Region: CopD; cl00563 66692006775 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 66692006776 aconitate hydratase; Validated; Region: PRK09277 66692006777 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 66692006778 substrate binding site [chemical binding]; other site 66692006779 ligand binding site [chemical binding]; other site 66692006780 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 66692006781 substrate binding site [chemical binding]; other site 66692006782 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 66692006783 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 66692006784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692006785 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 66692006786 Walker A/P-loop; other site 66692006787 ATP binding site [chemical binding]; other site 66692006788 Q-loop/lid; other site 66692006789 ABC transporter signature motif; other site 66692006790 Walker B; other site 66692006791 D-loop; other site 66692006792 H-loop/switch region; other site 66692006793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692006794 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 66692006795 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692006796 Walker A/P-loop; other site 66692006797 ATP binding site [chemical binding]; other site 66692006798 Q-loop/lid; other site 66692006799 ABC transporter signature motif; other site 66692006800 Walker B; other site 66692006801 D-loop; other site 66692006802 H-loop/switch region; other site 66692006803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 66692006804 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 66692006805 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 66692006806 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 66692006807 TPP-binding site [chemical binding]; other site 66692006808 dimer interface [polypeptide binding]; other site 66692006809 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 66692006810 PYR/PP interface [polypeptide binding]; other site 66692006811 dimer interface [polypeptide binding]; other site 66692006812 TPP binding site [chemical binding]; other site 66692006813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692006814 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 66692006815 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 66692006816 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 66692006817 catalytic residues [active] 66692006818 catalytic nucleophile [active] 66692006819 LexA repressor; Validated; Region: PRK00215 66692006820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692006821 putative DNA binding site [nucleotide binding]; other site 66692006822 putative Zn2+ binding site [ion binding]; other site 66692006823 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 66692006824 Catalytic site [active] 66692006825 drug efflux system protein MdtG; Provisional; Region: PRK09874 66692006826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692006827 putative substrate translocation pore; other site 66692006828 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 66692006829 active site 66692006830 DNA polymerase IV; Validated; Region: PRK02406 66692006831 DNA binding site [nucleotide binding] 66692006832 Domain of unknown function (DUF4269); Region: DUF4269; pfam14091 66692006833 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 66692006834 Transcriptional regulator [Transcription]; Region: IclR; COG1414 66692006835 Bacterial transcriptional regulator; Region: IclR; pfam01614 66692006836 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 66692006837 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 66692006838 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 66692006839 malate synthase G; Provisional; Region: PRK02999 66692006840 active site 66692006841 FAD binding domain; Region: FAD_binding_4; pfam01565 66692006842 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 66692006843 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 66692006844 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 66692006845 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692006846 Cysteine-rich domain; Region: CCG; pfam02754 66692006847 Cysteine-rich domain; Region: CCG; pfam02754 66692006848 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 66692006849 FAD binding domain; Region: FAD_binding_4; pfam01565 66692006850 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 66692006851 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692006852 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692006853 Coenzyme A binding pocket [chemical binding]; other site 66692006854 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 66692006855 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 66692006856 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 66692006857 Methionine gamma-lyase; Region: Met_gamma_lyase; pfam06838 66692006858 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692006859 catalytic residue [active] 66692006860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692006861 Walker A motif; other site 66692006862 ATP binding site [chemical binding]; other site 66692006863 Walker B motif; other site 66692006864 arginine finger; other site 66692006865 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 66692006866 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 66692006867 active site 66692006868 Int/Topo IB signature motif; other site 66692006869 DNA binding site [nucleotide binding] 66692006870 bacterial Hfq-like; Region: Hfq; cd01716 66692006871 hexamer interface [polypeptide binding]; other site 66692006872 Sm1 motif; other site 66692006873 RNA binding site [nucleotide binding]; other site 66692006874 Sm2 motif; other site 66692006875 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 66692006876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692006877 S-adenosylmethionine binding site [chemical binding]; other site 66692006878 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 66692006879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692006880 ATP binding site [chemical binding]; other site 66692006881 Mg2+ binding site [ion binding]; other site 66692006882 G-X-G motif; other site 66692006883 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 66692006884 ATP binding site [chemical binding]; other site 66692006885 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 66692006886 MutL C terminal dimerization domain; Region: MutL_C; pfam08676 66692006887 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 66692006888 MutS domain I; Region: MutS_I; pfam01624 66692006889 MutS domain II; Region: MutS_II; pfam05188 66692006890 MutS domain III; Region: MutS_III; pfam05192 66692006891 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 66692006892 Walker A/P-loop; other site 66692006893 ATP binding site [chemical binding]; other site 66692006894 Q-loop/lid; other site 66692006895 ABC transporter signature motif; other site 66692006896 Walker B; other site 66692006897 D-loop; other site 66692006898 H-loop/switch region; other site 66692006899 Outer spore coat protein E (CotE); Region: CotE; pfam10628 66692006900 Predicted membrane protein [Function unknown]; Region: COG4550 66692006901 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 66692006902 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 66692006903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692006904 FeS/SAM binding site; other site 66692006905 TRAM domain; Region: TRAM; pfam01938 66692006906 transglutaminase; Provisional; Region: tgl; PRK03187 66692006907 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 66692006908 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 66692006909 putative active site [active] 66692006910 metal binding site [ion binding]; metal-binding site 66692006911 homodimer binding site [polypeptide binding]; other site 66692006912 ribonuclease Y; Region: RNase_Y; TIGR03319 66692006913 KH domain; Region: KH_1; pfam00013 66692006914 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692006915 Zn2+ binding site [ion binding]; other site 66692006916 Mg2+ binding site [ion binding]; other site 66692006917 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 66692006918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692006919 Walker B; other site 66692006920 D-loop; other site 66692006921 H-loop/switch region; other site 66692006922 Autophagy protein Apg6; Region: APG6; pfam04111 66692006923 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 66692006924 AAA domain; Region: AAA_23; pfam13476 66692006925 Walker A/P-loop; other site 66692006926 ATP binding site [chemical binding]; other site 66692006927 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 66692006928 active site 66692006929 metal binding site [ion binding]; metal-binding site 66692006930 DNA binding site [nucleotide binding] 66692006931 recombinase A; Provisional; Region: recA; PRK09354 66692006932 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 66692006933 hexamer interface [polypeptide binding]; other site 66692006934 Walker A motif; other site 66692006935 ATP binding site [chemical binding]; other site 66692006936 Walker B motif; other site 66692006937 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 66692006938 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 66692006939 ATP binding site [chemical binding]; other site 66692006940 Mg++ binding site [ion binding]; other site 66692006941 motif III; other site 66692006942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692006943 nucleotide binding region [chemical binding]; other site 66692006944 ATP-binding site [chemical binding]; other site 66692006945 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 66692006946 RNA binding site [nucleotide binding]; other site 66692006947 competence damage-inducible protein A; Provisional; Region: PRK00549 66692006948 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 66692006949 putative MPT binding site; other site 66692006950 Pleckstrin homology-like domain; Region: PH-like; cl17171 66692006951 Competence-damaged protein; Region: CinA; pfam02464 66692006952 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 66692006953 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 66692006954 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692006955 non-specific DNA binding site [nucleotide binding]; other site 66692006956 salt bridge; other site 66692006957 sequence-specific DNA binding site [nucleotide binding]; other site 66692006958 ACT domain; Region: ACT; pfam01842 66692006959 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 66692006960 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 66692006961 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 66692006962 classical (c) SDRs; Region: SDR_c; cd05233 66692006963 NAD(P) binding site [chemical binding]; other site 66692006964 active site 66692006965 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 66692006966 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 66692006967 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 66692006968 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 66692006969 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 66692006970 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 66692006971 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692006972 DNA-binding site [nucleotide binding]; DNA binding site 66692006973 UTRA domain; Region: UTRA; pfam07702 66692006974 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 66692006975 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 66692006976 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 66692006977 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 66692006978 YlzJ-like protein; Region: YlzJ; pfam14035 66692006979 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 66692006980 active site 66692006981 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 66692006982 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 66692006983 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 66692006984 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 66692006985 dimer interface [polypeptide binding]; other site 66692006986 active site 66692006987 catalytic residue [active] 66692006988 aspartate kinase I; Reviewed; Region: PRK08210 66692006989 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 66692006990 nucleotide binding site [chemical binding]; other site 66692006991 substrate binding site [chemical binding]; other site 66692006992 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 66692006993 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 66692006994 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 66692006995 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 66692006996 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 66692006997 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 66692006998 dipicolinic acid synthetase, A subunit; Region: spore_dpaA; TIGR02853 66692006999 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; cl19125 66692007000 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 66692007001 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 66692007002 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 66692007003 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 66692007004 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 66692007005 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 66692007006 NodB motif; other site 66692007007 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 66692007008 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 66692007009 RNase E interface [polypeptide binding]; other site 66692007010 trimer interface [polypeptide binding]; other site 66692007011 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 66692007012 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 66692007013 RNase E interface [polypeptide binding]; other site 66692007014 trimer interface [polypeptide binding]; other site 66692007015 active site 66692007016 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 66692007017 putative nucleic acid binding region [nucleotide binding]; other site 66692007018 G-X-X-G motif; other site 66692007019 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 66692007020 RNA binding site [nucleotide binding]; other site 66692007021 domain interface; other site 66692007022 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 66692007023 16S/18S rRNA binding site [nucleotide binding]; other site 66692007024 S13e-L30e interaction site [polypeptide binding]; other site 66692007025 25S rRNA binding site [nucleotide binding]; other site 66692007026 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 66692007027 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 66692007028 active site 66692007029 Riboflavin kinase; Region: Flavokinase; smart00904 66692007030 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 66692007031 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 66692007032 RNA binding site [nucleotide binding]; other site 66692007033 active site 66692007034 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 66692007035 Protein of unknown function (DUF503); Region: DUF503; pfam04456 66692007036 translation initiation factor IF-2; Validated; Region: infB; PRK05306 66692007037 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 66692007038 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 66692007039 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 66692007040 G1 box; other site 66692007041 putative GEF interaction site [polypeptide binding]; other site 66692007042 GTP/Mg2+ binding site [chemical binding]; other site 66692007043 Switch I region; other site 66692007044 G2 box; other site 66692007045 G3 box; other site 66692007046 Switch II region; other site 66692007047 G4 box; other site 66692007048 G5 box; other site 66692007049 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 66692007050 Translation-initiation factor 2; Region: IF-2; pfam11987 66692007051 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 66692007052 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 66692007053 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 66692007054 putative RNA binding cleft [nucleotide binding]; other site 66692007055 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 66692007056 NusA N-terminal domain; Region: NusA_N; pfam08529 66692007057 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 66692007058 RNA binding site [nucleotide binding]; other site 66692007059 homodimer interface [polypeptide binding]; other site 66692007060 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 66692007061 G-X-X-G motif; other site 66692007062 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 66692007063 G-X-X-G motif; other site 66692007064 Sm and related proteins; Region: Sm_like; cl00259 66692007065 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 66692007066 putative oligomer interface [polypeptide binding]; other site 66692007067 putative RNA binding site [nucleotide binding]; other site 66692007068 DNA polymerase III PolC; Validated; Region: polC; PRK00448 66692007069 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 66692007070 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 66692007071 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 66692007072 generic binding surface II; other site 66692007073 generic binding surface I; other site 66692007074 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 66692007075 active site 66692007076 putative PHP Thumb interface [polypeptide binding]; other site 66692007077 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 66692007078 active site 66692007079 catalytic site [active] 66692007080 substrate binding site [chemical binding]; other site 66692007081 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 66692007082 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 66692007083 prolyl-tRNA synthetase; Provisional; Region: PRK09194 66692007084 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 66692007085 dimer interface [polypeptide binding]; other site 66692007086 motif 1; other site 66692007087 active site 66692007088 motif 2; other site 66692007089 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 66692007090 putative deacylase active site [active] 66692007091 motif 3; other site 66692007092 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 66692007093 anticodon binding site; other site 66692007094 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 66692007095 RIP metalloprotease RseP; Region: TIGR00054 66692007096 active site 66692007097 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 66692007098 protein binding site [polypeptide binding]; other site 66692007099 putative substrate binding region [chemical binding]; other site 66692007100 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 66692007101 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 66692007102 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 66692007103 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 66692007104 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 66692007105 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 66692007106 active site 66692007107 dimer interface [polypeptide binding]; other site 66692007108 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 66692007109 hinge region; other site 66692007110 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 66692007111 putative nucleotide binding site [chemical binding]; other site 66692007112 uridine monophosphate binding site [chemical binding]; other site 66692007113 homohexameric interface [polypeptide binding]; other site 66692007114 elongation factor Ts; Provisional; Region: tsf; PRK09377 66692007115 UBA/TS-N domain; Region: UBA; pfam00627 66692007116 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 66692007117 rRNA interaction site [nucleotide binding]; other site 66692007118 S8 interaction site; other site 66692007119 putative laminin-1 binding site; other site 66692007120 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 66692007121 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692007122 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 66692007123 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692007124 DNA binding residues [nucleotide binding] 66692007125 CheD chemotactic sensory transduction; Region: CheD; cl00810 66692007126 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 66692007127 Chemotaxis phosphatase CheX; Region: CheX; cl15816 66692007128 Chemotaxis phosphatase CheX; Region: CheX; cl15816 66692007129 CheB methylesterase; Region: CheB_methylest; pfam01339 66692007130 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 66692007131 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 66692007132 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 66692007133 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 66692007134 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 66692007135 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 66692007136 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 66692007137 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 66692007138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692007139 active site 66692007140 phosphorylation site [posttranslational modification] 66692007141 intermolecular recognition site; other site 66692007142 dimerization interface [polypeptide binding]; other site 66692007143 flagellar motor switch protein; Validated; Region: PRK08119 66692007144 CheC-like family; Region: CheC; pfam04509 66692007145 CheC-like family; Region: CheC; pfam04509 66692007146 flagellar motor switch protein FliN; Region: fliN; TIGR02480 66692007147 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 66692007148 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 66692007149 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 66692007150 Flagellar protein (FlbD); Region: FlbD; pfam06289 66692007151 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 66692007152 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 66692007153 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 66692007154 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 66692007155 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 66692007156 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 66692007157 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 66692007158 rod shape-determining protein MreC; Region: MreC; cl19252 66692007159 Uncharacterized conserved protein [Function unknown]; Region: COG3334 66692007160 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 66692007161 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 66692007162 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 66692007163 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 66692007164 Walker A motif/ATP binding site; other site 66692007165 Walker B motif; other site 66692007166 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 66692007167 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 66692007168 Flagellar assembly protein FliH; Region: FliH; cl19405 66692007169 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 66692007170 FliG N-terminal domain; Region: FliG_N; pfam14842 66692007171 FliG middle domain; Region: FliG_M; pfam14841 66692007172 FliG C-terminal domain; Region: FliG_C; pfam01706 66692007173 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 66692007174 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 66692007175 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 66692007176 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 66692007177 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 66692007178 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 66692007179 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 66692007180 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 66692007181 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 66692007182 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 66692007183 transcriptional repressor CodY; Validated; Region: PRK04158 66692007184 CodY GAF-like domain; Region: CodY; pfam06018 66692007185 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 66692007186 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 66692007187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692007188 Walker A motif; other site 66692007189 ATP binding site [chemical binding]; other site 66692007190 Walker B motif; other site 66692007191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692007192 Walker B motif; other site 66692007193 arginine finger; other site 66692007194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 66692007195 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 66692007196 active site 66692007197 HslU subunit interaction site [polypeptide binding]; other site 66692007198 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 66692007199 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 66692007200 active site 66692007201 DNA binding site [nucleotide binding] 66692007202 Int/Topo IB signature motif; other site 66692007203 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 66692007204 Glucose inhibited division protein A; Region: GIDA; pfam01134 66692007205 DNA topoisomerase I; Validated; Region: PRK05582 66692007206 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 66692007207 active site 66692007208 interdomain interaction site; other site 66692007209 putative metal-binding site [ion binding]; other site 66692007210 nucleotide binding site [chemical binding]; other site 66692007211 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 66692007212 domain I; other site 66692007213 DNA binding groove [nucleotide binding] 66692007214 phosphate binding site [ion binding]; other site 66692007215 domain II; other site 66692007216 domain III; other site 66692007217 nucleotide binding site [chemical binding]; other site 66692007218 catalytic site [active] 66692007219 domain IV; other site 66692007220 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 66692007221 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 66692007222 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 66692007223 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 66692007224 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 66692007225 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 66692007226 CoA binding domain; Region: CoA_binding; pfam02629 66692007227 CoA-ligase; Region: Ligase_CoA; pfam00549 66692007228 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 66692007229 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 66692007230 CoA-ligase; Region: Ligase_CoA; pfam00549 66692007231 FlhB HrpN YscU SpaS Family; Region: Bac_export_2; cl19167 66692007232 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 66692007233 RNA/DNA hybrid binding site [nucleotide binding]; other site 66692007234 active site 66692007235 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 66692007236 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 66692007237 GTP/Mg2+ binding site [chemical binding]; other site 66692007238 G4 box; other site 66692007239 G5 box; other site 66692007240 G1 box; other site 66692007241 Switch I region; other site 66692007242 G2 box; other site 66692007243 G3 box; other site 66692007244 Switch II region; other site 66692007245 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 66692007246 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 66692007247 Catalytic site [active] 66692007248 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 66692007249 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 66692007250 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 66692007251 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 66692007252 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 66692007253 active site 66692007254 nucleotide binding site [chemical binding]; other site 66692007255 HIGH motif; other site 66692007256 KMSKS motif; other site 66692007257 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 66692007258 tRNA binding surface [nucleotide binding]; other site 66692007259 anticodon binding site; other site 66692007260 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 66692007261 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 66692007262 RimM N-terminal domain; Region: RimM; pfam01782 66692007263 PRC-barrel domain; Region: PRC; pfam05239 66692007264 YlqD protein; Region: YlqD; pfam11068 66692007265 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 66692007266 G-X-X-G motif; other site 66692007267 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 66692007268 signal recognition particle protein; Provisional; Region: PRK10867 66692007269 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 66692007270 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 66692007271 P loop; other site 66692007272 GTP binding site [chemical binding]; other site 66692007273 Signal peptide binding domain; Region: SRP_SPB; pfam02978 66692007274 putative DNA-binding protein; Validated; Region: PRK00118 66692007275 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 66692007276 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 66692007277 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 66692007278 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 66692007279 P loop; other site 66692007280 GTP binding site [chemical binding]; other site 66692007281 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 66692007282 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 66692007283 Walker A/P-loop; other site 66692007284 ATP binding site [chemical binding]; other site 66692007285 Q-loop/lid; other site 66692007286 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 66692007287 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 66692007288 Trypsin-like peptidase domain; Region: Trypsin_2; cl19303 66692007289 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 66692007290 ABC transporter signature motif; other site 66692007291 Walker B; other site 66692007292 D-loop; other site 66692007293 H-loop/switch region; other site 66692007294 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 66692007295 ribonuclease III; Reviewed; Region: rnc; PRK00102 66692007296 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 66692007297 dimerization interface [polypeptide binding]; other site 66692007298 active site 66692007299 metal binding site [ion binding]; metal-binding site 66692007300 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 66692007301 dsRNA binding site [nucleotide binding]; other site 66692007302 acyl carrier protein; Provisional; Region: acpP; PRK00982 66692007303 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 66692007304 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 66692007305 NAD(P) binding site [chemical binding]; other site 66692007306 homotetramer interface [polypeptide binding]; other site 66692007307 homodimer interface [polypeptide binding]; other site 66692007308 active site 66692007309 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 66692007310 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 66692007311 putative phosphate acyltransferase; Provisional; Region: PRK05331 66692007312 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 66692007313 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 66692007314 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 66692007315 active site 2 [active] 66692007316 active site 1 [active] 66692007317 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 66692007318 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 66692007319 generic binding surface II; other site 66692007320 ssDNA binding site; other site 66692007321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692007322 ATP binding site [chemical binding]; other site 66692007323 putative Mg++ binding site [ion binding]; other site 66692007324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692007325 nucleotide binding region [chemical binding]; other site 66692007326 ATP-binding site [chemical binding]; other site 66692007327 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 66692007328 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 66692007329 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 66692007330 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 66692007331 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 66692007332 putative L-serine binding site [chemical binding]; other site 66692007333 EDD domain protein, DegV family; Region: DegV; TIGR00762 66692007334 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 66692007335 DAK2 domain; Region: Dak2; pfam02734 66692007336 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 66692007337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 66692007338 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 66692007339 stage V sporulation protein M; Provisional; Region: spoVM; PRK14741 66692007340 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 66692007341 substrate binding site [chemical binding]; other site 66692007342 hexamer interface [polypeptide binding]; other site 66692007343 metal binding site [ion binding]; metal-binding site 66692007344 GTPase RsgA; Reviewed; Region: PRK00098 66692007345 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 66692007346 RNA binding site [nucleotide binding]; other site 66692007347 homodimer interface [polypeptide binding]; other site 66692007348 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 66692007349 GTPase/Zn-binding domain interface [polypeptide binding]; other site 66692007350 GTP/Mg2+ binding site [chemical binding]; other site 66692007351 G4 box; other site 66692007352 G5 box; other site 66692007353 G1 box; other site 66692007354 Switch I region; other site 66692007355 G2 box; other site 66692007356 G3 box; other site 66692007357 Switch II region; other site 66692007358 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 66692007359 Catalytic domain of Protein Kinases; Region: PKc; cd00180 66692007360 active site 66692007361 ATP binding site [chemical binding]; other site 66692007362 substrate binding site [chemical binding]; other site 66692007363 activation loop (A-loop); other site 66692007364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 66692007365 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 66692007366 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 66692007367 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 66692007368 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 66692007369 active site 66692007370 16S rRNA methyltransferase B; Provisional; Region: PRK14902 66692007371 NusB family; Region: NusB; pfam01029 66692007372 putative RNA binding site [nucleotide binding]; other site 66692007373 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692007374 S-adenosylmethionine binding site [chemical binding]; other site 66692007375 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 66692007376 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 66692007377 putative active site [active] 66692007378 substrate binding site [chemical binding]; other site 66692007379 putative cosubstrate binding site; other site 66692007380 catalytic site [active] 66692007381 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 66692007382 substrate binding site [chemical binding]; other site 66692007383 primosome assembly protein PriA; Validated; Region: PRK05580 66692007384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692007385 ATP binding site [chemical binding]; other site 66692007386 putative Mg++ binding site [ion binding]; other site 66692007387 helicase superfamily c-terminal domain; Region: HELICc; smart00490 66692007388 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 66692007389 Flavoprotein; Region: Flavoprotein; cl19190 66692007390 DNA / pantothenate metabolizm flavoprotein; Region: DFP; pfam04127 66692007391 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 66692007392 Guanylate kinase; Region: Guanylate_kin; pfam00625 66692007393 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 66692007394 catalytic site [active] 66692007395 G-X2-G-X-G-K; other site 66692007396 hypothetical protein; Provisional; Region: PRK04323 66692007397 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 66692007398 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 66692007399 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 66692007400 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 66692007401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692007402 motif II; other site 66692007403 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 66692007404 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 66692007405 Domain of unknown function (DUF814); Region: DUF814; pfam05670 66692007406 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 66692007407 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692007408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692007409 S-adenosylmethionine binding site [chemical binding]; other site 66692007410 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692007411 active site 66692007412 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 66692007413 active site 66692007414 dimer interface [polypeptide binding]; other site 66692007415 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 66692007416 heterodimer interface [polypeptide binding]; other site 66692007417 active site 66692007418 FMN binding site [chemical binding]; other site 66692007419 homodimer interface [polypeptide binding]; other site 66692007420 substrate binding site [chemical binding]; other site 66692007421 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 66692007422 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 66692007423 FAD binding pocket [chemical binding]; other site 66692007424 FAD binding motif [chemical binding]; other site 66692007425 phosphate binding motif [ion binding]; other site 66692007426 beta-alpha-beta structure motif; other site 66692007427 NAD binding pocket [chemical binding]; other site 66692007428 Iron coordination center [ion binding]; other site 66692007429 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 66692007430 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692007431 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 66692007432 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 66692007433 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692007434 ATP-grasp domain; Region: ATP-grasp_4; cl17255 66692007435 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 66692007436 IMP binding site; other site 66692007437 dimer interface [polypeptide binding]; other site 66692007438 interdomain contacts; other site 66692007439 partial ornithine binding site; other site 66692007440 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 66692007441 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 66692007442 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 66692007443 catalytic site [active] 66692007444 subunit interface [polypeptide binding]; other site 66692007445 dihydroorotase; Validated; Region: pyrC; PRK09357 66692007446 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692007447 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 66692007448 active site 66692007449 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 66692007450 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 66692007451 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 66692007452 Sulfate transporter family; Region: Sulfate_transp; cl19250 66692007453 uracil-xanthine permease; Region: ncs2; TIGR00801 66692007454 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692007455 active site 66692007456 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 66692007457 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692007458 RNA binding surface [nucleotide binding]; other site 66692007459 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 66692007460 active site 66692007461 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 66692007462 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 66692007463 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 66692007464 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 66692007465 active site 66692007466 HIGH motif; other site 66692007467 KMSKS motif; other site 66692007468 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 66692007469 tRNA binding surface [nucleotide binding]; other site 66692007470 anticodon binding site; other site 66692007471 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 66692007472 DivIVA protein; Region: DivIVA; pfam05103 66692007473 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 66692007474 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 66692007475 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692007476 RNA binding surface [nucleotide binding]; other site 66692007477 YGGT family; Region: YGGT; pfam02325 66692007478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 66692007479 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 66692007480 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 66692007481 catalytic residue [active] 66692007482 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 66692007483 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 66692007484 sporulation sigma factor SigG; Reviewed; Region: PRK08215 66692007485 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692007486 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 66692007487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692007488 DNA binding residues [nucleotide binding] 66692007489 sporulation sigma factor SigE; Reviewed; Region: PRK08301 66692007490 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692007491 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692007492 DNA binding residues [nucleotide binding] 66692007493 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 66692007494 cell division protein FtsZ; Validated; Region: PRK09330 66692007495 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 66692007496 nucleotide binding site [chemical binding]; other site 66692007497 SulA interaction site; other site 66692007498 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 66692007499 Cell division protein FtsA; Region: FtsA; smart00842 66692007500 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692007501 nucleotide binding site [chemical binding]; other site 66692007502 Cell division protein FtsA; Region: FtsA; pfam14450 66692007503 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 66692007504 Cell division protein FtsQ; Region: FtsQ; pfam03799 66692007505 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 66692007506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692007507 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 66692007508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 66692007509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 66692007510 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 66692007511 Mg++ binding site [ion binding]; other site 66692007512 putative catalytic motif [active] 66692007513 putative substrate binding site [chemical binding]; other site 66692007514 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 66692007515 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 66692007516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 66692007517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 66692007518 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 66692007519 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 66692007520 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 66692007521 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 66692007522 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 66692007523 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 66692007524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 66692007525 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 66692007526 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 66692007527 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 66692007528 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 66692007529 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 66692007530 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 66692007531 Cell division protein FtsL; Region: FtsL; cl11433 66692007532 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 66692007533 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 66692007534 MraZ protein; Region: MraZ; pfam02381 66692007535 MraZ protein; Region: MraZ; pfam02381 66692007536 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 66692007537 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 66692007538 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 66692007539 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 66692007540 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 66692007541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692007542 Coenzyme A binding pocket [chemical binding]; other site 66692007543 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692007544 basic leucine zipper DNA-binding and multimerization region of GCN4 and related proteins; Region: B_zip1; cl02576 66692007545 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 66692007546 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 66692007547 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 66692007548 hypothetical protein; Provisional; Region: PRK13670 66692007549 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 66692007550 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 66692007551 protein binding site [polypeptide binding]; other site 66692007552 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 66692007553 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 66692007554 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 66692007555 active site 66692007556 nucleophile elbow; other site 66692007557 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 66692007558 Nucleoside recognition; Region: Gate; pfam07670 66692007559 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 66692007560 active site 66692007561 (T/H)XGH motif; other site 66692007562 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692007563 S-adenosylmethionine binding site [chemical binding]; other site 66692007564 hypothetical protein; Provisional; Region: PRK02886 66692007565 Protein of unknown function (DUF964); Region: DUF964; cl01483 66692007566 ATP-grasp domain; Region: ATP-grasp_4; cl17255 66692007567 YlbE-like protein; Region: YlbE; pfam14003 66692007568 Putative coat protein; Region: YlbD_coat; pfam14071 66692007569 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 66692007570 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 66692007571 CoenzymeA binding site [chemical binding]; other site 66692007572 subunit interaction site [polypeptide binding]; other site 66692007573 PHB binding site; other site 66692007574 CAP-associated N-terminal; Region: CAP_assoc_N; pfam14504 66692007575 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 66692007576 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 66692007577 YugN-like family; Region: YugN; pfam08868 66692007578 Predicted membrane protein [Function unknown]; Region: COG2322 66692007579 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 66692007580 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 66692007581 Subunit I/III interface [polypeptide binding]; other site 66692007582 Subunit III/IV interface [polypeptide binding]; other site 66692007583 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 66692007584 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 66692007585 D-pathway; other site 66692007586 Putative ubiquinol binding site [chemical binding]; other site 66692007587 Low-spin heme (heme b) binding site [chemical binding]; other site 66692007588 Putative water exit pathway; other site 66692007589 Binuclear center (heme o3/CuB) [ion binding]; other site 66692007590 K-pathway; other site 66692007591 Putative proton exit pathway; other site 66692007592 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 66692007593 The cupredoxin domain of Caa3 type Cytochrome c oxidase subunit II; Region: CuRO_CcO_Caa3_II; cd04213 66692007594 oligomer interface [polypeptide binding]; other site 66692007595 CuA binuclear center [ion binding]; other site 66692007596 Cytochrome c; Region: Cytochrom_C; pfam00034 66692007597 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 66692007598 pyruvate carboxylase; Reviewed; Region: PRK12999 66692007599 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692007600 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 66692007601 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 66692007602 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 66692007603 active site 66692007604 catalytic residues [active] 66692007605 metal binding site [ion binding]; metal-binding site 66692007606 homodimer binding site [polypeptide binding]; other site 66692007607 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 66692007608 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 66692007609 carboxyltransferase (CT) interaction site; other site 66692007610 biotinylation site [posttranslational modification]; other site 66692007611 hypothetical protein; Provisional; Region: PRK13666 66692007612 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 66692007613 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 66692007614 putative active site [active] 66692007615 PhoH-like protein; Region: PhoH; cl17668 66692007616 Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; pfam09963 66692007617 YlaH-like protein; Region: YlaH; pfam14036 66692007618 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 66692007619 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 66692007620 G1 box; other site 66692007621 putative GEF interaction site [polypeptide binding]; other site 66692007622 GTP/Mg2+ binding site [chemical binding]; other site 66692007623 Switch I region; other site 66692007624 G2 box; other site 66692007625 G3 box; other site 66692007626 Switch II region; other site 66692007627 G4 box; other site 66692007628 G5 box; other site 66692007629 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 66692007630 Elongation Factor G, domain II; Region: EFG_II; pfam14492 66692007631 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 66692007632 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 66692007633 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 66692007634 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 66692007635 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 66692007636 active site 66692007637 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 66692007638 hypothetical protein; Provisional; Region: PRK04387 66692007639 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 66692007640 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 66692007641 homodimer interface [polypeptide binding]; other site 66692007642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692007643 catalytic residue [active] 66692007644 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 66692007645 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 66692007646 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 66692007647 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 66692007648 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 66692007649 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 66692007650 NodB motif; other site 66692007651 active site 66692007652 catalytic site [active] 66692007653 metal binding site [ion binding]; metal-binding site 66692007654 BCCT family transporter; Region: BCCT; pfam02028 66692007655 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 66692007656 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692007657 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692007658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692007659 dimer interface [polypeptide binding]; other site 66692007660 conserved gate region; other site 66692007661 putative PBP binding loops; other site 66692007662 ABC-ATPase subunit interface; other site 66692007663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692007664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692007665 dimer interface [polypeptide binding]; other site 66692007666 conserved gate region; other site 66692007667 putative PBP binding loops; other site 66692007668 ABC-ATPase subunit interface; other site 66692007669 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692007670 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 66692007671 peptide binding site [polypeptide binding]; other site 66692007672 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 66692007673 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692007674 Walker A/P-loop; other site 66692007675 ATP binding site [chemical binding]; other site 66692007676 Q-loop/lid; other site 66692007677 ABC transporter signature motif; other site 66692007678 Walker B; other site 66692007679 D-loop; other site 66692007680 H-loop/switch region; other site 66692007681 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692007682 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692007683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692007684 Walker A/P-loop; other site 66692007685 ATP binding site [chemical binding]; other site 66692007686 Q-loop/lid; other site 66692007687 ABC transporter signature motif; other site 66692007688 Walker B; other site 66692007689 D-loop; other site 66692007690 H-loop/switch region; other site 66692007691 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692007692 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 66692007693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692007694 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692007695 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 66692007696 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 66692007697 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 66692007698 E3 interaction surface; other site 66692007699 lipoyl attachment site [posttranslational modification]; other site 66692007700 e3 binding domain; Region: E3_binding; pfam02817 66692007701 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 66692007702 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 66692007703 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 66692007704 alpha subunit interface [polypeptide binding]; other site 66692007705 TPP binding site [chemical binding]; other site 66692007706 heterodimer interface [polypeptide binding]; other site 66692007707 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692007708 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 66692007709 TPP-binding site [chemical binding]; other site 66692007710 heterodimer interface [polypeptide binding]; other site 66692007711 tetramer interface [polypeptide binding]; other site 66692007712 phosphorylation loop region [posttranslational modification] 66692007713 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 66692007714 Protein of unknown function (Tiny_TM_bacill); Region: Tiny_TM_bacill; pfam09680 66692007715 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 66692007716 active site 66692007717 catalytic residues [active] 66692007718 metal binding site [ion binding]; metal-binding site 66692007719 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 66692007720 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 66692007721 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 66692007722 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 66692007723 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 66692007724 TrkA-N domain; Region: TrkA_N; pfam02254 66692007725 TrkA-C domain; Region: TrkA_C; pfam02080 66692007726 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 66692007727 catalytic residues [active] 66692007728 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 66692007729 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 66692007730 dimer interface [polypeptide binding]; other site 66692007731 decamer (pentamer of dimers) interface [polypeptide binding]; other site 66692007732 catalytic triad [active] 66692007733 peroxidatic and resolving cysteines [active] 66692007734 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 66692007735 Mechanosensitive ion channel; Region: MS_channel; pfam00924 66692007736 hypothetical protein; Provisional; Region: PRK03094 66692007737 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692007738 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 66692007739 metal binding site [ion binding]; metal-binding site 66692007740 putative dimer interface [polypeptide binding]; other site 66692007741 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 66692007742 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692007743 inhibitor-cofactor binding pocket; inhibition site 66692007744 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692007745 catalytic residue [active] 66692007746 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 66692007747 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 66692007748 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 66692007749 putative trimer interface [polypeptide binding]; other site 66692007750 putative CoA binding site [chemical binding]; other site 66692007751 Predicted permeases [General function prediction only]; Region: COG0679 66692007752 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692007753 Zn2+ binding site [ion binding]; other site 66692007754 Mg2+ binding site [ion binding]; other site 66692007755 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 66692007756 Mechanosensitive ion channel; Region: MS_channel; pfam00924 66692007757 CopC domain; Region: CopC; pfam04234 66692007758 sporulation integral membrane protein YtvI; Region: spore_ytvI; TIGR02872 66692007759 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 66692007760 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 66692007761 NAD(P) binding site [chemical binding]; other site 66692007762 putative active site [active] 66692007763 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 66692007764 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 66692007765 putative metal binding site [ion binding]; other site 66692007766 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 66692007767 active site 66692007768 FMN binding site [chemical binding]; other site 66692007769 substrate binding site [chemical binding]; other site 66692007770 homotetramer interface [polypeptide binding]; other site 66692007771 catalytic residue [active] 66692007772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692007773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692007774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 66692007775 metal-binding site [ion binding] 66692007776 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 66692007777 putative homodimer interface [polypeptide binding]; other site 66692007778 putative homotetramer interface [polypeptide binding]; other site 66692007779 putative allosteric switch controlling residues; other site 66692007780 putative metal binding site [ion binding]; other site 66692007781 putative homodimer-homodimer interface [polypeptide binding]; other site 66692007782 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 66692007783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692007784 active site 66692007785 motif I; other site 66692007786 motif II; other site 66692007787 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692007788 Disulphide isomerase; Region: Disulph_isomer; pfam06491 66692007789 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 66692007790 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 66692007791 E3 interaction surface; other site 66692007792 lipoyl attachment site [posttranslational modification]; other site 66692007793 e3 binding domain; Region: E3_binding; pfam02817 66692007794 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 66692007795 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 66692007796 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 66692007797 alpha subunit interface [polypeptide binding]; other site 66692007798 TPP binding site [chemical binding]; other site 66692007799 heterodimer interface [polypeptide binding]; other site 66692007800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692007801 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 66692007802 tetramer interface [polypeptide binding]; other site 66692007803 TPP-binding site [chemical binding]; other site 66692007804 heterodimer interface [polypeptide binding]; other site 66692007805 phosphorylation loop region [posttranslational modification] 66692007806 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 66692007807 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692007808 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 66692007809 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 66692007810 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 66692007811 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 66692007812 NAD binding site [chemical binding]; other site 66692007813 Phe binding site; other site 66692007814 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692007815 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 66692007816 putative active site [active] 66692007817 heme pocket [chemical binding]; other site 66692007818 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692007819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692007820 Walker A motif; other site 66692007821 ATP binding site [chemical binding]; other site 66692007822 Walker B motif; other site 66692007823 arginine finger; other site 66692007824 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692007825 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 66692007826 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 66692007827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692007828 active site 66692007829 phosphorylation site [posttranslational modification] 66692007830 intermolecular recognition site; other site 66692007831 dimerization interface [polypeptide binding]; other site 66692007832 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 66692007833 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 66692007834 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 66692007835 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 66692007836 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 66692007837 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 66692007838 Walker A/P-loop; other site 66692007839 ATP binding site [chemical binding]; other site 66692007840 Q-loop/lid; other site 66692007841 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 66692007842 ABC transporter signature motif; other site 66692007843 Walker B; other site 66692007844 D-loop; other site 66692007845 H-loop/switch region; other site 66692007846 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 66692007847 arginine repressor; Provisional; Region: PRK04280 66692007848 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 66692007849 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 66692007850 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692007851 RNA binding surface [nucleotide binding]; other site 66692007852 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 66692007853 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 66692007854 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 66692007855 TPP-binding site; other site 66692007856 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 66692007857 PYR/PP interface [polypeptide binding]; other site 66692007858 dimer interface [polypeptide binding]; other site 66692007859 TPP binding site [chemical binding]; other site 66692007860 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692007861 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 66692007862 substrate binding pocket [chemical binding]; other site 66692007863 chain length determination region; other site 66692007864 active site lid residues [active] 66692007865 substrate-Mg2+ binding site; other site 66692007866 catalytic residues [active] 66692007867 aspartate-rich region 1; other site 66692007868 aspartate-rich region 2; other site 66692007869 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 66692007870 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 66692007871 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 66692007872 generic binding surface II; other site 66692007873 generic binding surface I; other site 66692007874 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 66692007875 putative RNA binding site [nucleotide binding]; other site 66692007876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 66692007877 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 66692007878 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692007879 ATP-grasp domain; Region: ATP-grasp_4; cl17255 66692007880 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 66692007881 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 66692007882 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 66692007883 carboxyltransferase (CT) interaction site; other site 66692007884 biotinylation site [posttranslational modification]; other site 66692007885 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 66692007886 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 66692007887 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 66692007888 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 66692007889 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 66692007890 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 66692007891 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 66692007892 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 66692007893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692007894 Walker A motif; other site 66692007895 ATP binding site [chemical binding]; other site 66692007896 Walker B motif; other site 66692007897 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 66692007898 YfzA-like protein; Region: YfzA; pfam14118 66692007899 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 66692007900 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 66692007901 ADP binding site [chemical binding]; other site 66692007902 magnesium binding site [ion binding]; other site 66692007903 putative shikimate binding site; other site 66692007904 elongation factor P; Validated; Region: PRK00529 66692007905 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 66692007906 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 66692007907 RNA binding site [nucleotide binding]; other site 66692007908 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 66692007909 RNA binding site [nucleotide binding]; other site 66692007910 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 66692007911 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 66692007912 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 66692007913 active site 66692007914 Conserved membrane protein YqhR; Region: YqhR; pfam11085 66692007915 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 66692007916 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 66692007917 active site 66692007918 nucleophile elbow; other site 66692007919 manganese transport transcriptional regulator; Provisional; Region: PRK03902 66692007920 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 66692007921 Iron dependent repressor, metal binding and dimerization domain; Region: Fe_dep_repr_C; pfam02742 66692007922 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 66692007923 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692007924 FeS/SAM binding site; other site 66692007925 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 66692007926 homodimer interface [polypeptide binding]; other site 66692007927 substrate-cofactor binding pocket; other site 66692007928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692007929 catalytic residue [active] 66692007930 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 66692007931 Part of AAA domain; Region: AAA_19; pfam13245 66692007932 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 66692007933 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 66692007934 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 66692007935 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 66692007936 active site residue [active] 66692007937 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 66692007938 tetramer interface [polypeptide binding]; other site 66692007939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692007940 catalytic residue [active] 66692007941 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 66692007942 tetramer interface [polypeptide binding]; other site 66692007943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692007944 catalytic residue [active] 66692007945 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 66692007946 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 66692007947 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 66692007948 DEAD-like helicases superfamily; Region: DEXDc; smart00487 66692007949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692007950 ATP binding site [chemical binding]; other site 66692007951 putative Mg++ binding site [ion binding]; other site 66692007952 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 66692007953 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692007954 nucleotide binding region [chemical binding]; other site 66692007955 ATP-binding site [chemical binding]; other site 66692007956 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 66692007957 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 66692007958 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 66692007959 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 66692007960 YqzE-like protein; Region: YqzE; pfam14038 66692007961 ComG operon protein 7; Region: ComGG; pfam14173 66692007962 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 66692007963 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 66692007964 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 66692007965 Haemolytic domain; Region: Haemolytic; pfam01809 66692007966 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 66692007967 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 66692007968 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 66692007969 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 66692007970 Walker A motif; other site 66692007971 ATP binding site [chemical binding]; other site 66692007972 Walker B motif; other site 66692007973 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 66692007974 Part of AAA domain; Region: AAA_19; pfam13245 66692007975 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 66692007976 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 66692007977 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 66692007978 Spore Coat Protein X and V domain; Region: Coat_X; pfam07552 66692007979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692007980 S-adenosylmethionine binding site [chemical binding]; other site 66692007981 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 66692007982 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 66692007983 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 66692007984 NAD binding site [chemical binding]; other site 66692007985 homotetramer interface [polypeptide binding]; other site 66692007986 homodimer interface [polypeptide binding]; other site 66692007987 substrate binding site [chemical binding]; other site 66692007988 active site 66692007989 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 66692007990 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 66692007991 active site 66692007992 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 66692007993 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 66692007994 synthetase active site [active] 66692007995 NTP binding site [chemical binding]; other site 66692007996 metal binding site [ion binding]; metal-binding site 66692007997 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 66692007998 putative active site [active] 66692007999 putative metal binding residues [ion binding]; other site 66692008000 signature motif; other site 66692008001 putative triphosphate binding site [ion binding]; other site 66692008002 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 66692008003 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 66692008004 N-acetyl-D-glucosamine binding site [chemical binding]; other site 66692008005 catalytic residue [active] 66692008006 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 66692008007 apolar tunnel; other site 66692008008 heme binding site [chemical binding]; other site 66692008009 dimerization interface [polypeptide binding]; other site 66692008010 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 66692008011 catalytic residues [active] 66692008012 Competence protein CoiA-like family; Region: CoiA; cl11541 66692008013 adaptor protein; Provisional; Region: PRK02315 66692008014 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 66692008015 putative catalytic residues [active] 66692008016 thiol/disulfide switch; other site 66692008017 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 66692008018 Helix-turn-helix domain; Region: HTH_17; cl17695 66692008019 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 66692008020 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 66692008021 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692008022 Zn2+ binding site [ion binding]; other site 66692008023 Mg2+ binding site [ion binding]; other site 66692008024 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 66692008025 catalytic residues [active] 66692008026 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 66692008027 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 66692008028 active site 66692008029 HIGH motif; other site 66692008030 dimer interface [polypeptide binding]; other site 66692008031 KMSKS motif; other site 66692008032 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 66692008033 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 66692008034 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 66692008035 synthetase active site [active] 66692008036 NTP binding site [chemical binding]; other site 66692008037 metal binding site [ion binding]; metal-binding site 66692008038 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 66692008039 ATP-binding site [chemical binding]; other site 66692008040 CoA-binding site [chemical binding]; other site 66692008041 Mg2+-binding site [ion binding]; other site 66692008042 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 66692008043 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 66692008044 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692008045 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 66692008046 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 66692008047 FOG: CBS domain [General function prediction only]; Region: COG0517 66692008048 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 66692008049 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 66692008050 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 66692008051 active site 66692008052 NTP binding site [chemical binding]; other site 66692008053 metal binding triad [ion binding]; metal-binding site 66692008054 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 66692008055 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 66692008056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 66692008057 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 66692008058 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 66692008059 dimer interface [polypeptide binding]; other site 66692008060 active site 66692008061 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 66692008062 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 66692008063 dimer interface [polypeptide binding]; other site 66692008064 active site 66692008065 CoA binding pocket [chemical binding]; other site 66692008066 ComZ; Region: ComZ; pfam10815 66692008067 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 66692008068 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 66692008069 G1 box; other site 66692008070 putative GEF interaction site [polypeptide binding]; other site 66692008071 GTP/Mg2+ binding site [chemical binding]; other site 66692008072 Switch I region; other site 66692008073 G2 box; other site 66692008074 G3 box; other site 66692008075 Switch II region; other site 66692008076 G4 box; other site 66692008077 G5 box; other site 66692008078 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 66692008079 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 66692008080 extended (e) SDRs; Region: SDR_e; cd08946 66692008081 NAD(P) binding site [chemical binding]; other site 66692008082 active site 66692008083 substrate binding site [chemical binding]; other site 66692008084 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329 66692008085 ornithine carbamoyltransferase; Provisional; Region: PRK00779 66692008086 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 66692008087 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 66692008088 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 66692008089 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692008090 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 66692008091 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 66692008092 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692008093 ATP-grasp domain; Region: ATP-grasp_4; cl17255 66692008094 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 66692008095 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 66692008096 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 66692008097 catalytic site [active] 66692008098 subunit interface [polypeptide binding]; other site 66692008099 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 66692008100 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692008101 inhibitor-cofactor binding pocket; inhibition site 66692008102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692008103 catalytic residue [active] 66692008104 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 66692008105 nucleotide binding site [chemical binding]; other site 66692008106 N-acetyl-L-glutamate binding site [chemical binding]; other site 66692008107 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 66692008108 heterotetramer interface [polypeptide binding]; other site 66692008109 active site pocket [active] 66692008110 cleavage site 66692008111 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 66692008112 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 66692008113 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 66692008114 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 66692008115 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692008116 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 66692008117 active site 66692008118 motif I; other site 66692008119 motif II; other site 66692008120 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692008121 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692008122 Coenzyme A binding pocket [chemical binding]; other site 66692008123 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 66692008124 SNF2 Helicase protein; Region: DUF3670; pfam12419 66692008125 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 66692008126 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692008127 ATP binding site [chemical binding]; other site 66692008128 putative Mg++ binding site [ion binding]; other site 66692008129 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692008130 nucleotide binding region [chemical binding]; other site 66692008131 ATP-binding site [chemical binding]; other site 66692008132 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 66692008133 Uncharacterized conserved protein [Function unknown]; Region: COG1284 66692008134 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692008135 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692008136 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 66692008137 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692008138 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 66692008139 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 66692008140 active site residue [active] 66692008141 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 66692008142 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 66692008143 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 66692008144 Amidinotransferase; Region: Amidinotransf; cl19186 66692008145 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 66692008146 RHS Repeat; Region: RHS_repeat; pfam05593 66692008147 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 66692008148 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 66692008149 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 66692008150 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 66692008151 RHS Repeat; Region: RHS_repeat; pfam05593 66692008152 RHS Repeat; Region: RHS_repeat; pfam05593 66692008153 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 66692008154 RHS protein; Region: RHS; pfam03527 66692008155 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 66692008156 IDEAL domain; Region: IDEAL; pfam08858 66692008157 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 66692008158 active site 66692008159 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 66692008160 dimer interface [polypeptide binding]; other site 66692008161 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 66692008162 Ligand Binding Site [chemical binding]; other site 66692008163 Molecular Tunnel; other site 66692008164 CheW-like domain; Region: CheW; pfam01584 66692008165 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 66692008166 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 66692008167 putative binding surface; other site 66692008168 active site 66692008169 P2 response regulator binding domain; Region: P2; pfam07194 66692008170 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 66692008171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692008172 ATP binding site [chemical binding]; other site 66692008173 Mg2+ binding site [ion binding]; other site 66692008174 G-X-G motif; other site 66692008175 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 66692008176 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 66692008177 Part of AAA domain; Region: AAA_19; pfam13245 66692008178 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 66692008179 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 66692008180 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 66692008181 PhoU domain; Region: PhoU; pfam01895 66692008182 PhoU domain; Region: PhoU; pfam01895 66692008183 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 66692008184 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 66692008185 Walker A/P-loop; other site 66692008186 ATP binding site [chemical binding]; other site 66692008187 Q-loop/lid; other site 66692008188 ABC transporter signature motif; other site 66692008189 Walker B; other site 66692008190 D-loop; other site 66692008191 H-loop/switch region; other site 66692008192 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 66692008193 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 66692008194 Walker A/P-loop; other site 66692008195 ATP binding site [chemical binding]; other site 66692008196 Q-loop/lid; other site 66692008197 ABC transporter signature motif; other site 66692008198 Walker B; other site 66692008199 D-loop; other site 66692008200 H-loop/switch region; other site 66692008201 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 66692008202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692008203 dimer interface [polypeptide binding]; other site 66692008204 conserved gate region; other site 66692008205 putative PBP binding loops; other site 66692008206 ABC-ATPase subunit interface; other site 66692008207 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 66692008208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692008209 dimer interface [polypeptide binding]; other site 66692008210 conserved gate region; other site 66692008211 putative PBP binding loops; other site 66692008212 ABC-ATPase subunit interface; other site 66692008213 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 66692008214 DinB family; Region: DinB; cl17821 66692008215 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 66692008216 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 66692008217 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 66692008218 catalytic triad [active] 66692008219 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 66692008220 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 66692008221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692008222 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 66692008223 Fe-S cluster binding site [ion binding]; other site 66692008224 active site 66692008225 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 66692008226 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 66692008227 active site 66692008228 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 66692008229 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 66692008230 hypothetical protein; Provisional; Region: PRK14553 66692008231 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 66692008232 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 66692008233 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 66692008234 homodimer interface [polypeptide binding]; other site 66692008235 oligonucleotide binding site [chemical binding]; other site 66692008236 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 66692008237 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 66692008238 Peptidase family M50; Region: Peptidase_M50; pfam02163 66692008239 active site 66692008240 putative substrate binding region [chemical binding]; other site 66692008241 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 66692008242 Peptidase family M23; Region: Peptidase_M23; pfam01551 66692008243 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692008244 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 66692008245 active site 66692008246 catalytic tetrad [active] 66692008247 BioY family; Region: BioY; pfam02632 66692008248 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 66692008249 dimer interface [polypeptide binding]; other site 66692008250 putative active site [active] 66692008251 trimer interface [polypeptide binding]; other site 66692008252 intracellular protease, PfpI family; Region: PfpI; TIGR01382 66692008253 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 66692008254 proposed catalytic triad [active] 66692008255 conserved cys residue [active] 66692008256 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 66692008257 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 66692008258 P-loop; other site 66692008259 ADP binding residues [chemical binding]; other site 66692008260 Switch I; other site 66692008261 Switch II; other site 66692008262 septum formation inhibitor; Reviewed; Region: minC; PRK00513 66692008263 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 66692008264 rod shape-determining protein MreD; Region: MreD; cl01087 66692008265 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 66692008266 rod shape-determining protein MreB; Provisional; Region: PRK13927 66692008267 MreB and similar proteins; Region: MreB_like; cd10225 66692008268 nucleotide binding site [chemical binding]; other site 66692008269 Mg binding site [ion binding]; other site 66692008270 putative protofilament interaction site [polypeptide binding]; other site 66692008271 RodZ interaction site [polypeptide binding]; other site 66692008272 hypothetical protein; Reviewed; Region: PRK00024 66692008273 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 66692008274 MPN+ (JAMM) motif; other site 66692008275 Zinc-binding site [ion binding]; other site 66692008276 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 66692008277 active site 66692008278 dimer interface [polypeptide binding]; other site 66692008279 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 66692008280 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 66692008281 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 66692008282 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 66692008283 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 66692008284 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 66692008285 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 66692008286 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 66692008287 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 66692008288 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 66692008289 active site 66692008290 HIGH motif; other site 66692008291 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 66692008292 KMSKS motif; other site 66692008293 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 66692008294 tRNA binding surface [nucleotide binding]; other site 66692008295 anticodon binding site; other site 66692008296 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 66692008297 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 66692008298 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 66692008299 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 66692008300 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692008301 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 66692008302 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692008303 inhibitor-cofactor binding pocket; inhibition site 66692008304 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692008305 catalytic residue [active] 66692008306 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 66692008307 dimer interface [polypeptide binding]; other site 66692008308 active site 66692008309 Schiff base residues; other site 66692008310 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 66692008311 active site 66692008312 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 66692008313 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 66692008314 domain interfaces; other site 66692008315 active site 66692008316 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 66692008317 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 66692008318 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 66692008319 tRNA; other site 66692008320 putative tRNA binding site [nucleotide binding]; other site 66692008321 putative NADP binding site [chemical binding]; other site 66692008322 Glutamyl-tRNAGlu reductase, dimerization domain; Region: GlutR_dimer; pfam00745 66692008323 Predicted GTPase [General function prediction only]; Region: COG0218 66692008324 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 66692008325 G1 box; other site 66692008326 GTP/Mg2+ binding site [chemical binding]; other site 66692008327 Switch I region; other site 66692008328 G2 box; other site 66692008329 G3 box; other site 66692008330 Switch II region; other site 66692008331 G4 box; other site 66692008332 G5 box; other site 66692008333 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 66692008334 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 66692008335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 66692008336 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692008337 Walker A motif; other site 66692008338 ATP binding site [chemical binding]; other site 66692008339 Walker B motif; other site 66692008340 arginine finger; other site 66692008341 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 66692008342 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 66692008343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692008344 Walker A motif; other site 66692008345 ATP binding site [chemical binding]; other site 66692008346 Walker B motif; other site 66692008347 arginine finger; other site 66692008348 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 66692008349 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 66692008350 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 66692008351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692008352 Walker A motif; other site 66692008353 ATP binding site [chemical binding]; other site 66692008354 Walker B motif; other site 66692008355 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 66692008356 trigger factor; Provisional; Region: tig; PRK01490 66692008357 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 66692008358 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 66692008359 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 66692008360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692008361 binding surface 66692008362 TPR motif; other site 66692008363 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 66692008364 substrate binding site [chemical binding]; other site 66692008365 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 66692008366 substrate binding site [chemical binding]; other site 66692008367 ligand binding site [chemical binding]; other site 66692008368 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 66692008369 2-isopropylmalate synthase; Validated; Region: PRK00915 66692008370 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 66692008371 active site 66692008372 catalytic residues [active] 66692008373 metal binding site [ion binding]; metal-binding site 66692008374 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 66692008375 ketol-acid reductoisomerase; Provisional; Region: PRK05479 66692008376 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 66692008377 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 66692008378 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 66692008379 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 66692008380 putative valine binding site [chemical binding]; other site 66692008381 dimer interface [polypeptide binding]; other site 66692008382 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 66692008383 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 66692008384 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 66692008385 PYR/PP interface [polypeptide binding]; other site 66692008386 dimer interface [polypeptide binding]; other site 66692008387 TPP binding site [chemical binding]; other site 66692008388 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 66692008389 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 66692008390 TPP-binding site [chemical binding]; other site 66692008391 dimer interface [polypeptide binding]; other site 66692008392 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 66692008393 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 66692008394 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 66692008395 DXD motif; other site 66692008396 The first Cupredoxin domain of Bilirubin oxidase (BOD), the bacterial endospore coat component CotA, and similar proteins; Region: CuRO_1_BOD_CotA_like; cd13844 66692008397 dimer interface [polypeptide binding]; other site 66692008398 hexamer interface [polypeptide binding]; other site 66692008399 Domain 2 interface [polypeptide binding]; other site 66692008400 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 66692008401 Domain 3 interface [polypeptide binding]; other site 66692008402 trinuclear Cu binding site [ion binding]; other site 66692008403 The second Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_2_CotA_like; cd13868 66692008404 Domain 1 interface [polypeptide binding]; other site 66692008405 Domain 3 interface [polypeptide binding]; other site 66692008406 The third Cupredoxin domain of bacterial laccases including CotA, a bacterial endospore coat component; Region: CuRO_3_CotA_like; cd13891 66692008407 Domain 1 interface [polypeptide binding]; other site 66692008408 Type 1 (T1) Cu binding site [ion binding]; other site 66692008409 Domain 2 interface [polypeptide binding]; other site 66692008410 trinuclear Cu binding site [ion binding]; other site 66692008411 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 66692008412 active site 66692008413 metal binding site [ion binding]; metal-binding site 66692008414 homotetramer interface [polypeptide binding]; other site 66692008415 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 66692008416 active site 66692008417 dimerization interface [polypeptide binding]; other site 66692008418 ribonuclease PH; Reviewed; Region: rph; PRK00173 66692008419 Ribonuclease PH; Region: RNase_PH_bact; cd11362 66692008420 hexamer interface [polypeptide binding]; other site 66692008421 active site 66692008422 Sporulation and spore germination; Region: Germane; pfam10646 66692008423 Spore germination protein [General function prediction only]; Region: COG5401 66692008424 Sporulation and spore germination; Region: Germane; pfam10646 66692008425 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 66692008426 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 66692008427 active site residue [active] 66692008428 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 66692008429 4Fe-4S binding domain; Region: Fer4; pfam00037 66692008430 glutamate racemase; Provisional; Region: PRK00865 66692008431 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692008432 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 66692008433 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 66692008434 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 66692008435 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 66692008436 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 66692008437 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 66692008438 dimerization domain swap beta strand [polypeptide binding]; other site 66692008439 regulatory protein interface [polypeptide binding]; other site 66692008440 active site 66692008441 regulatory phosphorylation site [posttranslational modification]; other site 66692008442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692008443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692008444 DNA binding residues [nucleotide binding] 66692008445 dimerization interface [polypeptide binding]; other site 66692008446 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 66692008447 active site 66692008448 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 66692008449 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 66692008450 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692008451 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 66692008452 L-aspartate oxidase; Provisional; Region: PRK06175 66692008453 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 66692008454 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 66692008455 putative Iron-sulfur protein interface [polypeptide binding]; other site 66692008456 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 66692008457 proximal heme binding site [chemical binding]; other site 66692008458 distal heme binding site [chemical binding]; other site 66692008459 putative dimer interface [polypeptide binding]; other site 66692008460 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 66692008461 Cation transport protein; Region: TrkH; cl17365 66692008462 Cation transport protein; Region: TrkH; cl17365 66692008463 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 66692008464 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 66692008465 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 66692008466 GIY-YIG motif/motif A; other site 66692008467 active site 66692008468 catalytic site [active] 66692008469 putative DNA binding site [nucleotide binding]; other site 66692008470 metal binding site [ion binding]; metal-binding site 66692008471 UvrB/uvrC motif; Region: UVR; pfam02151 66692008472 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 66692008473 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 66692008474 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 66692008475 catalytic residues [active] 66692008476 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 66692008477 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 66692008478 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 66692008479 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 66692008480 Ligand binding site [chemical binding]; other site 66692008481 enoyl-CoA hydratase; Provisional; Region: PRK07658 66692008482 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 66692008483 substrate binding site [chemical binding]; other site 66692008484 oxyanion hole (OAH) forming residues; other site 66692008485 trimer interface [polypeptide binding]; other site 66692008486 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 66692008487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692008488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692008489 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 66692008490 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 66692008491 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 66692008492 acyl-activating enzyme (AAE) consensus motif; other site 66692008493 putative AMP binding site [chemical binding]; other site 66692008494 putative active site [active] 66692008495 putative CoA binding site [chemical binding]; other site 66692008496 Predicted membrane protein [Function unknown]; Region: COG3766 66692008497 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 66692008498 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 66692008499 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 66692008500 MutS domain III; Region: MutS_III; pfam05192 66692008501 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 66692008502 Walker A/P-loop; other site 66692008503 ATP binding site [chemical binding]; other site 66692008504 Q-loop/lid; other site 66692008505 ABC transporter signature motif; other site 66692008506 Walker B; other site 66692008507 D-loop; other site 66692008508 H-loop/switch region; other site 66692008509 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 66692008510 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 66692008511 Smr domain; Region: Smr; pfam01713 66692008512 hypothetical protein; Provisional; Region: PRK08609 66692008513 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 66692008514 active site 66692008515 primer binding site [nucleotide binding]; other site 66692008516 NTP binding site [chemical binding]; other site 66692008517 metal binding triad [ion binding]; metal-binding site 66692008518 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 66692008519 active site 66692008520 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 66692008521 Cell division protein ZapA; Region: ZapA; cl01146 66692008522 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 66692008523 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 66692008524 putative tRNA-binding site [nucleotide binding]; other site 66692008525 B3/4 domain; Region: B3_4; pfam03483 66692008526 tRNA synthetase B5 domain; Region: B5; smart00874 66692008527 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 66692008528 dimer interface [polypeptide binding]; other site 66692008529 motif 1; other site 66692008530 motif 3; other site 66692008531 motif 2; other site 66692008532 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 66692008533 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 66692008534 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 66692008535 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 66692008536 dimer interface [polypeptide binding]; other site 66692008537 motif 1; other site 66692008538 active site 66692008539 motif 2; other site 66692008540 motif 3; other site 66692008541 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 66692008542 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 66692008543 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 66692008544 small acid-soluble spore protein SspI; Provisional; Region: PRK02955 66692008545 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 66692008546 oligomer interface [polypeptide binding]; other site 66692008547 active site 66692008548 metal binding site [ion binding]; metal-binding site 66692008549 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 66692008550 Na binding site [ion binding]; other site 66692008551 Protein of unknown function, DUF485; Region: DUF485; pfam04341 66692008552 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 66692008553 23S rRNA binding site [nucleotide binding]; other site 66692008554 L21 binding site [polypeptide binding]; other site 66692008555 L13 binding site [polypeptide binding]; other site 66692008556 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 66692008557 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 66692008558 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 66692008559 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 66692008560 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 66692008561 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 66692008562 FtsX-like permease family; Region: FtsX; pfam02687 66692008563 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692008564 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692008565 Walker A/P-loop; other site 66692008566 ATP binding site [chemical binding]; other site 66692008567 Q-loop/lid; other site 66692008568 ABC transporter signature motif; other site 66692008569 Walker B; other site 66692008570 D-loop; other site 66692008571 H-loop/switch region; other site 66692008572 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 66692008573 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 66692008574 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 66692008575 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692008576 active site 66692008577 catalytic tetrad [active] 66692008578 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692008579 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692008580 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692008581 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 66692008582 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 66692008583 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 66692008584 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 66692008585 active site 66692008586 dimer interface [polypeptide binding]; other site 66692008587 motif 1; other site 66692008588 motif 2; other site 66692008589 motif 3; other site 66692008590 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 66692008591 anticodon binding site; other site 66692008592 putative sporulation protein YtxC; Region: spo_ytxC; TIGR02834 66692008593 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 66692008594 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692008595 FeS/SAM binding site; other site 66692008596 primosomal protein DnaI; Reviewed; Region: PRK08939 66692008597 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 66692008598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692008599 Walker A motif; other site 66692008600 ATP binding site [chemical binding]; other site 66692008601 Walker B motif; other site 66692008602 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 66692008603 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 66692008604 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 66692008605 ATP cone domain; Region: ATP-cone; pfam03477 66692008606 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 66692008607 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 66692008608 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 66692008609 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 66692008610 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 66692008611 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 66692008612 CoA-binding site [chemical binding]; other site 66692008613 ATP-binding [chemical binding]; other site 66692008614 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 66692008615 Domain of unknown function DUF; Region: DUF204; pfam02659 66692008616 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 66692008617 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 66692008618 DNA binding site [nucleotide binding] 66692008619 catalytic residue [active] 66692008620 H2TH interface [polypeptide binding]; other site 66692008621 putative catalytic residues [active] 66692008622 turnover-facilitating residue; other site 66692008623 intercalation triad [nucleotide binding]; other site 66692008624 8OG recognition residue [nucleotide binding]; other site 66692008625 putative reading head residues; other site 66692008626 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 66692008627 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 66692008628 DNA polymerase I; Provisional; Region: PRK05755 66692008629 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 66692008630 active site 66692008631 metal binding site 1 [ion binding]; metal-binding site 66692008632 putative 5' ssDNA interaction site; other site 66692008633 metal binding site 3; metal-binding site 66692008634 metal binding site 2 [ion binding]; metal-binding site 66692008635 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 66692008636 putative DNA binding site [nucleotide binding]; other site 66692008637 putative metal binding site [ion binding]; other site 66692008638 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 66692008639 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 66692008640 active site 66692008641 DNA binding site [nucleotide binding] 66692008642 catalytic site [active] 66692008643 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 66692008644 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692008645 dimerization interface [polypeptide binding]; other site 66692008646 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 66692008647 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692008648 dimer interface [polypeptide binding]; other site 66692008649 phosphorylation site [posttranslational modification] 66692008650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692008651 ATP binding site [chemical binding]; other site 66692008652 Mg2+ binding site [ion binding]; other site 66692008653 G-X-G motif; other site 66692008654 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692008655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692008656 active site 66692008657 phosphorylation site [posttranslational modification] 66692008658 intermolecular recognition site; other site 66692008659 dimerization interface [polypeptide binding]; other site 66692008660 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692008661 DNA binding site [nucleotide binding] 66692008662 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 66692008663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692008664 putative DNA binding site [nucleotide binding]; other site 66692008665 putative Zn2+ binding site [ion binding]; other site 66692008666 AsnC family; Region: AsnC_trans_reg; pfam01037 66692008667 malate dehydrogenase; Reviewed; Region: PRK06223 66692008668 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 66692008669 NAD(P) binding site [chemical binding]; other site 66692008670 dimer interface [polypeptide binding]; other site 66692008671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692008672 substrate binding site [chemical binding]; other site 66692008673 isocitrate dehydrogenase; Reviewed; Region: PRK07006 66692008674 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 66692008675 dimer interface [polypeptide binding]; other site 66692008676 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 66692008677 active site 66692008678 citrylCoA binding site [chemical binding]; other site 66692008679 oxalacetate/citrate binding site [chemical binding]; other site 66692008680 coenzyme A binding site [chemical binding]; other site 66692008681 catalytic triad [active] 66692008682 Protein of unknown function (DUF441); Region: DUF441; pfam04284 66692008683 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 66692008684 pyruvate kinase; Provisional; Region: PRK06354 66692008685 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 66692008686 domain interfaces; other site 66692008687 active site 66692008688 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 66692008689 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 66692008690 active site 66692008691 ADP/pyrophosphate binding site [chemical binding]; other site 66692008692 dimerization interface [polypeptide binding]; other site 66692008693 allosteric effector site; other site 66692008694 fructose-1,6-bisphosphate binding site; other site 66692008695 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 66692008696 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 66692008697 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692008698 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692008699 DNA-binding site [nucleotide binding]; DNA binding site 66692008700 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 66692008701 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 66692008702 Malic enzyme, N-terminal domain; Region: malic; pfam00390 66692008703 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 66692008704 putative NAD(P) binding site [chemical binding]; other site 66692008705 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 66692008706 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 66692008707 active site 66692008708 PHP Thumb interface [polypeptide binding]; other site 66692008709 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 66692008710 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 66692008711 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 66692008712 generic binding surface II; other site 66692008713 generic binding surface I; other site 66692008714 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 66692008715 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 66692008716 DHH family; Region: DHH; pfam01368 66692008717 DHHA1 domain; Region: DHHA1; pfam02272 66692008718 YtpI-like protein; Region: YtpI; pfam14007 66692008719 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 66692008720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 66692008721 DNA-binding site [nucleotide binding]; DNA binding site 66692008722 DRTGG domain; Region: DRTGG; pfam07085 66692008723 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 66692008724 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 66692008725 active site 2 [active] 66692008726 active site 1 [active] 66692008727 metal-dependent hydrolase; Provisional; Region: PRK00685 66692008728 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 66692008729 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 66692008730 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 66692008731 active site 66692008732 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 66692008733 classical (c) SDRs; Region: SDR_c; cd05233 66692008734 NAD(P) binding site [chemical binding]; other site 66692008735 active site 66692008736 argininosuccinate lyase; Provisional; Region: PRK00855 66692008737 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 66692008738 active sites [active] 66692008739 tetramer interface [polypeptide binding]; other site 66692008740 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 66692008741 ANP binding site [chemical binding]; other site 66692008742 Substrate Binding Site II [chemical binding]; other site 66692008743 Substrate Binding Site I [chemical binding]; other site 66692008744 EcsC protein family; Region: EcsC; pfam12787 66692008745 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 66692008746 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 66692008747 generic binding surface II; other site 66692008748 generic binding surface I; other site 66692008749 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 66692008750 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 66692008751 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692008752 S-adenosylmethionine binding site [chemical binding]; other site 66692008753 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 66692008754 dimer interface [polypeptide binding]; other site 66692008755 catalytic triad [active] 66692008756 peroxidatic and resolving cysteines [active] 66692008757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692008758 major facilitator superfamily transporter; Provisional; Region: PRK05122 66692008759 putative substrate translocation pore; other site 66692008760 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 66692008761 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 66692008762 RDD family; Region: RDD; pfam06271 66692008763 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 66692008764 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 66692008765 tandem repeat interface [polypeptide binding]; other site 66692008766 oligomer interface [polypeptide binding]; other site 66692008767 active site residues [active] 66692008768 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 66692008769 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 66692008770 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 66692008771 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 66692008772 Ligand Binding Site [chemical binding]; other site 66692008773 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 66692008774 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692008775 catalytic residue [active] 66692008776 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 66692008777 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 66692008778 histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856 66692008779 active site 66692008780 dimer interface [polypeptide binding]; other site 66692008781 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692008782 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692008783 Probable transposase; Region: OrfB_IS605; pfam01385 66692008784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 66692008785 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 66692008786 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 66692008787 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 66692008788 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 66692008789 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692008790 RNA binding surface [nucleotide binding]; other site 66692008791 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 66692008792 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 66692008793 active site 66692008794 HIGH motif; other site 66692008795 dimer interface [polypeptide binding]; other site 66692008796 KMSKS motif; other site 66692008797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692008798 RNA binding surface [nucleotide binding]; other site 66692008799 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 66692008800 Transglycosylase; Region: Transgly; pfam00912 66692008801 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 66692008802 acetyl-CoA synthetase; Provisional; Region: PRK04319 66692008803 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 66692008804 active site 66692008805 acyl-activating enzyme (AAE) consensus motif; other site 66692008806 putative CoA binding site [chemical binding]; other site 66692008807 AMP binding site [chemical binding]; other site 66692008808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692008809 Coenzyme A binding pocket [chemical binding]; other site 66692008810 FOG: CBS domain [General function prediction only]; Region: COG0517 66692008811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 66692008812 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 66692008813 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 66692008814 active site 66692008815 Zn binding site [ion binding]; other site 66692008816 catabolite control protein A; Region: ccpA; TIGR01481 66692008817 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692008818 DNA binding site [nucleotide binding] 66692008819 domain linker motif; other site 66692008820 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 66692008821 dimerization interface [polypeptide binding]; other site 66692008822 effector binding site; other site 66692008823 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 66692008824 Chorismate mutase type II; Region: CM_2; cl00693 66692008825 DAHP synthetase I family; Region: DAHP_synth_1; cl17225 66692008826 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 66692008827 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 66692008828 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 66692008829 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 66692008830 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 66692008831 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 66692008832 Serine-rich region of AP3B1, clathrin-adaptor complex; Region: SEEEED; cl19208 66692008833 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 66692008834 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 66692008835 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 66692008836 Domain of unknown function (DUF4479); Region: DUF4479; pfam14794 66692008837 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 66692008838 putative tRNA-binding site [nucleotide binding]; other site 66692008839 hypothetical protein; Provisional; Region: PRK13668 66692008840 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 66692008841 catalytic residues [active] 66692008842 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 66692008843 YtoQ family protein; Region: YtoQ_fam; TIGR03646 66692008844 NTPase; Reviewed; Region: PRK03114 66692008845 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 66692008846 oligomer interface [polypeptide binding]; other site 66692008847 active site 66692008848 metal binding site [ion binding]; metal-binding site 66692008849 Predicted small secreted protein [Function unknown]; Region: COG5584 66692008850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692008851 S-adenosylmethionine binding site [chemical binding]; other site 66692008852 YtzH-like protein; Region: YtzH; pfam14165 66692008853 Phosphotransferase enzyme family; Region: APH; pfam01636 66692008854 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 66692008855 active site 66692008856 ATP binding site [chemical binding]; other site 66692008857 substrate binding site [chemical binding]; other site 66692008858 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 66692008859 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 66692008860 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 66692008861 putative active site [active] 66692008862 putative substrate binding site [chemical binding]; other site 66692008863 putative cosubstrate binding site; other site 66692008864 catalytic site [active] 66692008865 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 66692008866 classical (c) SDRs; Region: SDR_c; cd05233 66692008867 NAD(P) binding site [chemical binding]; other site 66692008868 active site 66692008869 Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691 66692008870 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 66692008871 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 66692008872 E3 interaction surface; other site 66692008873 lipoyl attachment site [posttranslational modification]; other site 66692008874 e3 binding domain; Region: E3_binding; pfam02817 66692008875 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 66692008876 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 66692008877 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 66692008878 PYR/PP interface [polypeptide binding]; other site 66692008879 dimer interface [polypeptide binding]; other site 66692008880 TPP binding site [chemical binding]; other site 66692008881 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 66692008882 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 66692008883 tetramer interface [polypeptide binding]; other site 66692008884 TPP-binding site [chemical binding]; other site 66692008885 heterodimer interface [polypeptide binding]; other site 66692008886 phosphorylation loop region [posttranslational modification] 66692008887 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 66692008888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692008889 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 66692008890 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 66692008891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692008892 Walker A motif; other site 66692008893 ATP binding site [chemical binding]; other site 66692008894 Walker B motif; other site 66692008895 arginine finger; other site 66692008896 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 66692008897 LrgB-like family; Region: LrgB; cl00596 66692008898 LrgA family; Region: LrgA; cl00608 66692008899 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 66692008900 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 66692008901 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 66692008902 cysteine synthase; Region: PLN02565 66692008903 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 66692008904 dimer interface [polypeptide binding]; other site 66692008905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692008906 catalytic residue [active] 66692008907 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692008908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692008909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 66692008910 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692008911 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 66692008912 DNA binding residues [nucleotide binding] 66692008913 putative dimer interface [polypeptide binding]; other site 66692008914 short chain dehydrogenase; Provisional; Region: PRK06180 66692008915 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 66692008916 NADP binding site [chemical binding]; other site 66692008917 active site 66692008918 steroid binding site; other site 66692008919 FosB, a fosfomycin resistance protein, catalyzes the Mg(II) dependent addition of L-cysteine to the epoxide ring of fosfomycin; Region: FosB; cd08363 66692008920 putative active site [active] 66692008921 putative Mg binding site [ion binding]; other site 66692008922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692008923 putative DNA binding site [nucleotide binding]; other site 66692008924 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692008925 putative Zn2+ binding site [ion binding]; other site 66692008926 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 66692008927 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 66692008928 RNA binding surface [nucleotide binding]; other site 66692008929 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 66692008930 active site 66692008931 uracil binding [chemical binding]; other site 66692008932 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 66692008933 cell division protein FtsW; Region: ftsW; TIGR02614 66692008934 stage V sporulation protein B; Region: spore_V_B; TIGR02900 66692008935 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 66692008936 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 66692008937 Uncharacterized conserved protein [Function unknown]; Region: COG0432 66692008938 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692008939 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 66692008940 metal binding site [ion binding]; metal-binding site 66692008941 dimer interface [polypeptide binding]; other site 66692008942 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692008943 YolD-like protein; Region: YolD; pfam08863 66692008944 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 66692008945 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 66692008946 active site 66692008947 DNA binding site [nucleotide binding] 66692008948 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 66692008949 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 66692008950 Transposase; Region: DEDD_Tnp_IS110; pfam01548 66692008951 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 66692008952 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 66692008953 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 66692008954 active site 66692008955 metal binding site [ion binding]; metal-binding site 66692008956 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 66692008957 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692008958 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692008959 Phage lysis protein, holin; Region: Phage_holin; cl04675 66692008960 Prophage endopeptidase tail; Region: Prophage_tail; pfam06605 66692008961 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 66692008962 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 66692008963 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 66692008964 Phage tail protein; Region: Sipho_tail; pfam05709 66692008965 tape measure domain; Region: tape_meas_nterm; TIGR02675 66692008966 Uncharacterized archaeal coiled-coil protein [Function unknown]; Region: COG1340 66692008967 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 66692008968 Phage-related protein [Function unknown]; Region: COG5412 66692008969 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 66692008970 Peptidase family M23; Region: Peptidase_M23; pfam01551 66692008971 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 66692008972 N-acetyl-D-glucosamine binding site [chemical binding]; other site 66692008973 catalytic residue [active] 66692008974 Cdc37 N terminal kinase binding; Region: CDC37_N; cl03951 66692008975 Glycine zipper; Region: Gly-zipper_Omp; pfam13488 66692008976 Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094 66692008977 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 66692008978 Bacteriophage HK97-gp10, putative tail-component; Region: HK97-gp10_like; pfam04883 66692008979 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 66692008980 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 66692008981 Phage terminase large subunit; Region: Terminase_3; cl12054 66692008982 Terminase-like family; Region: Terminase_6; pfam03237 66692008983 Terminase small subunit; Region: Terminase_2; pfam03592 66692008984 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 66692008985 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 66692008986 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 66692008987 Endodeoxyribonuclease RusA; Region: RusA; cl01885 66692008988 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 66692008989 trimer interface [polypeptide binding]; other site 66692008990 active site 66692008991 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 66692008992 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 66692008993 dimer interface [polypeptide binding]; other site 66692008994 ssDNA binding site [nucleotide binding]; other site 66692008995 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692008996 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cl19095 66692008997 cofactor binding site; other site 66692008998 DNA binding site [nucleotide binding] 66692008999 substrate interaction site [chemical binding]; other site 66692009000 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 66692009001 active site 66692009002 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692009003 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 66692009004 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 66692009005 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 66692009006 DNA binding residues [nucleotide binding] 66692009007 hypothetical protein; Validated; Region: PRK08116 66692009008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692009009 Walker A motif; other site 66692009010 ATP binding site [chemical binding]; other site 66692009011 Walker B motif; other site 66692009012 arginine finger; other site 66692009013 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 66692009014 Phage anti-repressor protein [Transcription]; Region: COG3561 66692009015 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 66692009016 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 66692009017 non-specific DNA binding site [nucleotide binding]; other site 66692009018 salt bridge; other site 66692009019 sequence-specific DNA binding site [nucleotide binding]; other site 66692009020 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 66692009021 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 66692009022 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 66692009023 Protein of unknown function (DUF1071); Region: DUF1071; pfam06378 66692009024 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692009025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692009026 non-specific DNA binding site [nucleotide binding]; other site 66692009027 salt bridge; other site 66692009028 sequence-specific DNA binding site [nucleotide binding]; other site 66692009029 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 66692009030 Catalytic site [active] 66692009031 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 66692009032 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 66692009033 catalytic residues [active] 66692009034 catalytic nucleophile [active] 66692009035 Presynaptic Site I dimer interface [polypeptide binding]; other site 66692009036 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 66692009037 Synaptic Flat tetramer interface [polypeptide binding]; other site 66692009038 Synaptic Site I dimer interface [polypeptide binding]; other site 66692009039 DNA binding site [nucleotide binding] 66692009040 Recombinase; Region: Recombinase; pfam07508 66692009041 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 66692009042 HI0933-like protein; Region: HI0933_like; pfam03486 66692009043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692009044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692009045 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 66692009046 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 66692009047 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 66692009048 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692009049 metal binding site [ion binding]; metal-binding site 66692009050 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 66692009051 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 66692009052 active site 66692009053 HIGH motif; other site 66692009054 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 66692009055 KMSKS motif; other site 66692009056 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 66692009057 tRNA binding surface [nucleotide binding]; other site 66692009058 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 66692009059 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 66692009060 NAD binding site [chemical binding]; other site 66692009061 dimer interface [polypeptide binding]; other site 66692009062 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692009063 substrate binding site [chemical binding]; other site 66692009064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692009065 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692009066 putative substrate translocation pore; other site 66692009067 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692009068 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692009069 S-adenosylmethionine binding site [chemical binding]; other site 66692009070 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 66692009071 active site clefts [active] 66692009072 zinc binding site [ion binding]; other site 66692009073 dimer interface [polypeptide binding]; other site 66692009074 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 66692009075 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692009076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 66692009077 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 66692009078 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 66692009079 trimer interface [polypeptide binding]; other site 66692009080 putative metal binding site [ion binding]; other site 66692009081 S-adenosylmethionine synthetase; Validated; Region: PRK05250 66692009082 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 66692009083 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 66692009084 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 66692009085 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 66692009086 active site 66692009087 substrate-binding site [chemical binding]; other site 66692009088 metal-binding site [ion binding] 66692009089 ATP binding site [chemical binding]; other site 66692009090 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 66692009091 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692009092 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 66692009093 NMT1-like family; Region: NMT1_2; cl17432 66692009094 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 66692009095 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692009096 Walker A/P-loop; other site 66692009097 ATP binding site [chemical binding]; other site 66692009098 Q-loop/lid; other site 66692009099 ABC transporter signature motif; other site 66692009100 Walker B; other site 66692009101 D-loop; other site 66692009102 H-loop/switch region; other site 66692009103 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692009104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009105 dimer interface [polypeptide binding]; other site 66692009106 conserved gate region; other site 66692009107 putative PBP binding loops; other site 66692009108 ABC-ATPase subunit interface; other site 66692009109 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 66692009110 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 66692009111 nudix motif; other site 66692009112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692009113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692009114 putative substrate translocation pore; other site 66692009115 YwpF-like protein; Region: YwpF; pfam14183 66692009116 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 66692009117 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692009118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692009119 homodimer interface [polypeptide binding]; other site 66692009120 catalytic residue [active] 66692009121 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 66692009122 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 66692009123 Substrate-binding site [chemical binding]; other site 66692009124 Substrate specificity [chemical binding]; other site 66692009125 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 66692009126 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 66692009127 Substrate-binding site [chemical binding]; other site 66692009128 Substrate specificity [chemical binding]; other site 66692009129 Restriction endonuclease; Region: Mrr_cat; pfam04471 66692009130 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692009131 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 66692009132 putative ligand binding residues [chemical binding]; other site 66692009133 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 66692009134 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 66692009135 Walker A/P-loop; other site 66692009136 ATP binding site [chemical binding]; other site 66692009137 Q-loop/lid; other site 66692009138 ABC transporter signature motif; other site 66692009139 Walker B; other site 66692009140 D-loop; other site 66692009141 H-loop/switch region; other site 66692009142 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692009143 ABC-ATPase subunit interface; other site 66692009144 dimer interface [polypeptide binding]; other site 66692009145 putative PBP binding regions; other site 66692009146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692009147 ABC-ATPase subunit interface; other site 66692009148 dimer interface [polypeptide binding]; other site 66692009149 putative PBP binding regions; other site 66692009150 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 66692009151 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 66692009152 active site 66692009153 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 66692009154 DinB superfamily; Region: DinB_2; pfam12867 66692009155 hypothetical protein; Provisional; Region: PRK13673 66692009156 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 66692009157 Protoheme IX farnesyltransferase; Region: PT_UbiA_Cox10; cd13957 66692009158 putative active site [active] 66692009159 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 66692009160 DHH family; Region: DHH; pfam01368 66692009161 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 66692009162 DHHA2 domain; Region: DHHA2; pfam02833 66692009163 YugN-like family; Region: YugN; pfam08868 66692009164 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 66692009165 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 66692009166 active site 66692009167 dimer interface [polypeptide binding]; other site 66692009168 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 66692009169 dimer interface [polypeptide binding]; other site 66692009170 active site 66692009171 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 66692009172 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 66692009173 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 66692009174 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 66692009175 dimer interface [polypeptide binding]; other site 66692009176 active site 66692009177 metal binding site [ion binding]; metal-binding site 66692009178 Uncharacterized conserved protein [Function unknown]; Region: COG2155 66692009179 general stress protein 13; Validated; Region: PRK08059 66692009180 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 66692009181 RNA binding site [nucleotide binding]; other site 66692009182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 66692009183 DEAD-like helicases superfamily; Region: DEXDc; smart00487 66692009184 ATP binding site [chemical binding]; other site 66692009185 putative Mg++ binding site [ion binding]; other site 66692009186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692009187 nucleotide binding region [chemical binding]; other site 66692009188 ATP-binding site [chemical binding]; other site 66692009189 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 66692009190 substrate binding site [chemical binding]; other site 66692009191 multimerization interface [polypeptide binding]; other site 66692009192 ATP binding site [chemical binding]; other site 66692009193 aspartate aminotransferase; Provisional; Region: PRK05764 66692009194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692009195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692009196 homodimer interface [polypeptide binding]; other site 66692009197 catalytic residue [active] 66692009198 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 66692009199 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 66692009200 S-ribosylhomocysteinase; Provisional; Region: PRK02260 66692009201 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 66692009202 histone-like DNA-binding protein HU; Region: HU; cd13831 66692009203 dimer interface [polypeptide binding]; other site 66692009204 DNA binding site [nucleotide binding] 66692009205 Predicted permease [General function prediction only]; Region: COG2056 66692009206 Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726 66692009207 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 66692009208 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 66692009209 multifunctional aminopeptidase A; Provisional; Region: PRK00913 66692009210 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 66692009211 interface (dimer of trimers) [polypeptide binding]; other site 66692009212 Substrate-binding/catalytic site; other site 66692009213 Zn-binding sites [ion binding]; other site 66692009214 Divergent PAP2 family; Region: DUF212; pfam02681 66692009215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 66692009216 Putative membrane protein; Region: YuiB; pfam14068 66692009217 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 66692009218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692009219 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 66692009220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692009221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692009222 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 66692009223 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 66692009224 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 66692009225 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692009226 active site 66692009227 phosphorylation site [posttranslational modification] 66692009228 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692009229 HTH domain; Region: HTH_11; cl17392 66692009230 PRD domain; Region: PRD; pfam00874 66692009231 PRD domain; Region: PRD; pfam00874 66692009232 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692009233 active site 66692009234 P-loop; other site 66692009235 phosphorylation site [posttranslational modification] 66692009236 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 66692009237 active site 66692009238 phosphorylation site [posttranslational modification] 66692009239 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 66692009240 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 66692009241 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 66692009242 active site 66692009243 P-loop; other site 66692009244 phosphorylation site [posttranslational modification] 66692009245 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 66692009246 active site 66692009247 P-loop; other site 66692009248 phosphorylation site [posttranslational modification] 66692009249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692009250 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 66692009251 substrate binding pocket [chemical binding]; other site 66692009252 membrane-bound complex binding site; other site 66692009253 hinge residues; other site 66692009254 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 66692009255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009256 dimer interface [polypeptide binding]; other site 66692009257 conserved gate region; other site 66692009258 putative PBP binding loops; other site 66692009259 ABC-ATPase subunit interface; other site 66692009260 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 66692009261 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 66692009262 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692009263 FeS/SAM binding site; other site 66692009264 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 66692009265 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 66692009266 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 66692009267 hypothetical protein; Provisional; Region: PRK13669 66692009268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692009269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692009270 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 66692009271 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692009272 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 66692009273 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 66692009274 homoserine kinase; Provisional; Region: PRK01212 66692009275 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 66692009276 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 66692009277 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 66692009278 homodimer interface [polypeptide binding]; other site 66692009279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692009280 catalytic residue [active] 66692009281 homoserine dehydrogenase; Provisional; Region: PRK06349 66692009282 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 66692009283 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 66692009284 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 66692009285 spore coat protein YutH; Region: spore_yutH; TIGR02905 66692009286 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 66692009287 tetramer interfaces [polypeptide binding]; other site 66692009288 binuclear metal-binding site [ion binding]; other site 66692009289 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 66692009290 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692009291 active site 66692009292 motif I; other site 66692009293 motif II; other site 66692009294 Uncharacterized conserved protein [Function unknown]; Region: COG2445 66692009295 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 66692009296 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 66692009297 lipoyl synthase; Provisional; Region: PRK05481 66692009298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 66692009299 FeS/SAM binding site; other site 66692009300 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 66692009301 Peptidase family M23; Region: Peptidase_M23; pfam01551 66692009302 Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757 66692009303 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 66692009304 sporulation protein YunB; Region: spo_yunB; TIGR02832 66692009305 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 66692009306 folate binding site [chemical binding]; other site 66692009307 NADP+ binding site [chemical binding]; other site 66692009308 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 66692009309 dimerization interface [polypeptide binding]; other site 66692009310 active site 66692009311 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 66692009312 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 66692009313 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 66692009314 active site 66692009315 metal binding site [ion binding]; metal-binding site 66692009316 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 66692009317 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 66692009318 Uncharacterized conserved protein [Function unknown]; Region: COG1801 66692009319 Bacterial PH domain; Region: bPH_4; pfam06713 66692009320 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692009321 Protein of unknown function (DUF3130; Region: DUF3130; cl12867 66692009322 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 66692009323 Phosphotransferase enzyme family; Region: APH; pfam01636 66692009324 putative active site [active] 66692009325 putative substrate binding site [chemical binding]; other site 66692009326 ATP binding site [chemical binding]; other site 66692009327 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692009328 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692009329 intersubunit interface [polypeptide binding]; other site 66692009330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692009331 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692009332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692009333 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 66692009334 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692009335 active site 66692009336 catalytic tetrad [active] 66692009337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692009338 S-adenosylmethionine binding site [chemical binding]; other site 66692009339 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 66692009340 CAT RNA binding domain; Region: CAT_RBD; smart01061 66692009341 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 66692009342 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 66692009343 tetramer interface [polypeptide binding]; other site 66692009344 active site 66692009345 Mg2+/Mn2+ binding site [ion binding]; other site 66692009346 FeS assembly protein SufB; Region: sufB; TIGR01980 66692009347 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 66692009348 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 66692009349 trimerization site [polypeptide binding]; other site 66692009350 active site 66692009351 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 66692009352 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692009353 catalytic residue [active] 66692009354 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 66692009355 FeS assembly protein SufD; Region: sufD; TIGR01981 66692009356 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 66692009357 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 66692009358 Walker A/P-loop; other site 66692009359 ATP binding site [chemical binding]; other site 66692009360 Q-loop/lid; other site 66692009361 ABC transporter signature motif; other site 66692009362 Walker B; other site 66692009363 D-loop; other site 66692009364 H-loop/switch region; other site 66692009365 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 66692009366 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 66692009367 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 66692009368 putative binding site residues; other site 66692009369 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 66692009370 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 66692009371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009372 dimer interface [polypeptide binding]; other site 66692009373 conserved gate region; other site 66692009374 putative PBP binding loops; other site 66692009375 ABC-ATPase subunit interface; other site 66692009376 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 66692009377 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 66692009378 Walker A/P-loop; other site 66692009379 ATP binding site [chemical binding]; other site 66692009380 Q-loop/lid; other site 66692009381 ABC transporter signature motif; other site 66692009382 Walker B; other site 66692009383 D-loop; other site 66692009384 H-loop/switch region; other site 66692009385 NIL domain; Region: NIL; pfam09383 66692009386 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 66692009387 lipoyl attachment site [posttranslational modification]; other site 66692009388 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 66692009389 putative ArsC-like catalytic residues; other site 66692009390 putative TRX-like catalytic residues [active] 66692009391 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 66692009392 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 66692009393 active site 66692009394 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 66692009395 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 66692009396 dimer interface [polypeptide binding]; other site 66692009397 active site 66692009398 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 66692009399 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 66692009400 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 66692009401 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 66692009402 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 66692009403 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 66692009404 substrate binding site [chemical binding]; other site 66692009405 oxyanion hole (OAH) forming residues; other site 66692009406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692009407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692009408 putative substrate translocation pore; other site 66692009409 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 66692009410 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 66692009411 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 66692009412 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 66692009413 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 66692009414 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 66692009415 NodB motif; other site 66692009416 active site 66692009417 catalytic site [active] 66692009418 metal binding site [ion binding]; metal-binding site 66692009419 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 66692009420 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692009421 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692009422 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692009423 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 66692009424 inhibitor-cofactor binding pocket; inhibition site 66692009425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692009426 catalytic residue [active] 66692009427 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 66692009428 Nucleoside recognition; Region: Gate; pfam07670 66692009429 active site 66692009430 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 66692009431 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 66692009432 SmpB-tmRNA interface; other site 66692009433 Predicted membrane protein [Function unknown]; Region: COG2259 66692009434 ribonuclease R; Region: RNase_R; TIGR02063 66692009435 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 66692009436 RNB domain; Region: RNB; pfam00773 66692009437 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 66692009438 RNA binding site [nucleotide binding]; other site 66692009439 Esterase/lipase [General function prediction only]; Region: COG1647 66692009440 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692009441 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 66692009442 Esterase/lipase [General function prediction only]; Region: COG1647 66692009443 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692009444 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 66692009445 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 66692009446 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 66692009447 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 66692009448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 66692009449 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 66692009450 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cd00308 66692009451 metal binding site [ion binding]; metal-binding site 66692009452 substrate binding pocket [chemical binding]; other site 66692009453 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 66692009454 NAD(P) binding site [chemical binding]; other site 66692009455 catalytic residues [active] 66692009456 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 66692009457 inhibitor site; inhibition site 66692009458 active site 66692009459 dimer interface [polypeptide binding]; other site 66692009460 catalytic residue [active] 66692009461 Transcriptional regulators [Transcription]; Region: GntR; COG1802 66692009462 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692009463 DNA-binding site [nucleotide binding]; DNA binding site 66692009464 FCD domain; Region: FCD; pfam07729 66692009465 enolase; Provisional; Region: eno; PRK00077 66692009466 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 66692009467 dimer interface [polypeptide binding]; other site 66692009468 metal binding site [ion binding]; metal-binding site 66692009469 substrate binding pocket [chemical binding]; other site 66692009470 phosphoglyceromutase; Provisional; Region: PRK05434 66692009471 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 66692009472 substrate binding site [chemical binding]; other site 66692009473 dimer interface [polypeptide binding]; other site 66692009474 catalytic triad [active] 66692009475 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 66692009476 substrate binding site [chemical binding]; other site 66692009477 hinge regions; other site 66692009478 ADP binding site [chemical binding]; other site 66692009479 catalytic site [active] 66692009480 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 66692009481 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 66692009482 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 66692009483 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 66692009484 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 66692009485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692009486 TPR motif; other site 66692009487 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692009488 binding surface 66692009489 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692009490 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 66692009491 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 66692009492 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 66692009493 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 66692009494 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 66692009495 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 66692009496 oligomer interface [polypeptide binding]; other site 66692009497 active site residues [active] 66692009498 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 66692009499 hypothetical protein; Provisional; Region: PRK06446 66692009500 metal binding site [ion binding]; metal-binding site 66692009501 putative dimer interface [polypeptide binding]; other site 66692009502 Tic20-like protein; Region: Tic20; pfam09685 66692009503 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 66692009504 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 66692009505 Walker A/P-loop; other site 66692009506 ATP binding site [chemical binding]; other site 66692009507 Q-loop/lid; other site 66692009508 ABC transporter signature motif; other site 66692009509 Walker B; other site 66692009510 D-loop; other site 66692009511 H-loop/switch region; other site 66692009512 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 66692009513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009514 dimer interface [polypeptide binding]; other site 66692009515 conserved gate region; other site 66692009516 putative PBP binding loops; other site 66692009517 ABC-ATPase subunit interface; other site 66692009518 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 66692009519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009520 dimer interface [polypeptide binding]; other site 66692009521 conserved gate region; other site 66692009522 putative PBP binding loops; other site 66692009523 ABC-ATPase subunit interface; other site 66692009524 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 66692009525 dimerization domain swap beta strand [polypeptide binding]; other site 66692009526 regulatory protein interface [polypeptide binding]; other site 66692009527 active site 66692009528 regulatory phosphorylation site [posttranslational modification]; other site 66692009529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 66692009530 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 66692009531 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 66692009532 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 66692009533 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 66692009534 phosphate binding site [ion binding]; other site 66692009535 putative substrate binding pocket [chemical binding]; other site 66692009536 dimer interface [polypeptide binding]; other site 66692009537 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 66692009538 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 66692009539 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 66692009540 putative active site [active] 66692009541 nucleotide binding site [chemical binding]; other site 66692009542 nudix motif; other site 66692009543 putative metal binding site [ion binding]; other site 66692009544 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 66692009545 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692009546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692009547 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 66692009548 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692009549 binding surface 66692009550 TPR motif; other site 66692009551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692009552 binding surface 66692009553 TPR motif; other site 66692009554 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 66692009555 EamA-like transporter family; Region: EamA; cl17759 66692009556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692009557 Coenzyme A binding pocket [chemical binding]; other site 66692009558 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 66692009559 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 66692009560 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 66692009561 metal binding site [ion binding]; metal-binding site 66692009562 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 66692009563 substrate binding site [chemical binding]; other site 66692009564 glutamase interaction surface [polypeptide binding]; other site 66692009565 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 66692009566 catalytic residues [active] 66692009567 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 66692009568 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 66692009569 putative active site [active] 66692009570 oxyanion strand; other site 66692009571 catalytic triad [active] 66692009572 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 66692009573 putative active site pocket [active] 66692009574 4-fold oligomerization interface [polypeptide binding]; other site 66692009575 metal binding residues [ion binding]; metal-binding site 66692009576 3-fold/trimer interface [polypeptide binding]; other site 66692009577 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 66692009578 histidinol dehydrogenase; Region: hisD; TIGR00069 66692009579 NAD binding site [chemical binding]; other site 66692009580 dimerization interface [polypeptide binding]; other site 66692009581 product binding site; other site 66692009582 substrate binding site [chemical binding]; other site 66692009583 zinc binding site [ion binding]; other site 66692009584 catalytic residues [active] 66692009585 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 66692009586 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 66692009587 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 66692009588 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 66692009589 dimer interface [polypeptide binding]; other site 66692009590 motif 1; other site 66692009591 active site 66692009592 motif 2; other site 66692009593 motif 3; other site 66692009594 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 66692009595 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 66692009596 trimer interface [polypeptide binding]; other site 66692009597 active site 66692009598 substrate binding site [chemical binding]; other site 66692009599 CoA binding site [chemical binding]; other site 66692009600 pyrophosphatase PpaX; Provisional; Region: PRK13288 66692009601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692009602 active site 66692009603 motif I; other site 66692009604 motif II; other site 66692009605 Nucleoside recognition; Region: Gate; pfam07670 66692009606 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 66692009607 HPr kinase/phosphorylase; Provisional; Region: PRK05428 66692009608 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 66692009609 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 66692009610 Hpr binding site; other site 66692009611 active site 66692009612 homohexamer subunit interaction site [polypeptide binding]; other site 66692009613 Membrane protein of unknown function; Region: DUF360; pfam04020 66692009614 Uncharacterized conserved protein [Function unknown]; Region: COG3595 66692009615 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 66692009616 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 66692009617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 66692009618 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 66692009619 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 66692009620 excinuclease ABC subunit B; Provisional; Region: PRK05298 66692009621 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692009622 ATP binding site [chemical binding]; other site 66692009623 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692009624 nucleotide binding region [chemical binding]; other site 66692009625 ATP-binding site [chemical binding]; other site 66692009626 Ultra-violet resistance protein B; Region: UvrB; pfam12344 66692009627 UvrB/uvrC motif; Region: UVR; pfam02151 66692009628 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 66692009629 EamA-like transporter family; Region: EamA; pfam00892 66692009630 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 66692009631 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 66692009632 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 66692009633 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 66692009634 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 66692009635 protein binding site [polypeptide binding]; other site 66692009636 Catalytic dyad [active] 66692009637 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692009638 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 66692009639 Protein of unknown function (DUF342); Region: DUF342; cl19219 66692009640 Peptidase family M23; Region: Peptidase_M23; pfam01551 66692009641 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 66692009642 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 66692009643 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 66692009644 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692009645 Walker A/P-loop; other site 66692009646 ATP binding site [chemical binding]; other site 66692009647 Q-loop/lid; other site 66692009648 ABC transporter signature motif; other site 66692009649 Walker B; other site 66692009650 D-loop; other site 66692009651 H-loop/switch region; other site 66692009652 Uncharacterized conserved protein [Function unknown]; Region: COG1284 66692009653 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692009654 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 66692009655 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 66692009656 peptide chain release factor 2; Provisional; Region: PRK06746 66692009657 This domain is found in peptide chain release factors; Region: PCRF; smart00937 66692009658 RF-1 domain; Region: RF-1; pfam00472 66692009659 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 66692009660 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 66692009661 helicase superfamily c-terminal domain; Region: HELICc; smart00490 66692009662 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 66692009663 SEC-C motif; Region: SEC-C; pfam02810 66692009664 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 66692009665 30S subunit binding site; other site 66692009666 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 66692009667 DNA-binding site [nucleotide binding]; DNA binding site 66692009668 RNA-binding motif; other site 66692009669 Flagellar protein FliS; Region: FliS; cl00654 66692009670 flagellar capping protein; Validated; Region: fliD; PRK07737 66692009671 Flagellar hook-associated protein 2 N-terminus; Region: FliD_N; pfam02465 66692009672 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 66692009673 FlaG protein; Region: FlaG; cl00591 66692009674 carbon storage regulator; Provisional; Region: PRK01712 66692009675 flagellar assembly protein FliW; Provisional; Region: PRK13285 66692009676 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 66692009677 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 66692009678 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 66692009679 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 66692009680 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 66692009681 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 66692009682 FlgN protein; Region: FlgN; pfam05130 66692009683 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 66692009684 flagellar operon protein TIGR03826; Region: YvyF 66692009685 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 66692009686 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692009687 active site 66692009688 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 66692009689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 66692009690 ATP binding site [chemical binding]; other site 66692009691 putative Mg++ binding site [ion binding]; other site 66692009692 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692009693 nucleotide binding region [chemical binding]; other site 66692009694 ATP-binding site [chemical binding]; other site 66692009695 EDD domain protein, DegV family; Region: DegV; TIGR00762 66692009696 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692009697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692009698 active site 66692009699 phosphorylation site [posttranslational modification] 66692009700 intermolecular recognition site; other site 66692009701 dimerization interface [polypeptide binding]; other site 66692009702 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692009703 DNA binding residues [nucleotide binding] 66692009704 dimerization interface [polypeptide binding]; other site 66692009705 Sensor protein DegS; Region: DegS; pfam05384 66692009706 Histidine kinase; Region: HisKA_3; pfam07730 66692009707 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692009708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692009709 ATP binding site [chemical binding]; other site 66692009710 Mg2+ binding site [ion binding]; other site 66692009711 G-X-G motif; other site 66692009712 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 66692009713 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 66692009714 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 66692009715 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 66692009716 putative substrate binding pocket [chemical binding]; other site 66692009717 AC domain interface; other site 66692009718 catalytic triad [active] 66692009719 AB domain interface; other site 66692009720 interchain disulfide; other site 66692009721 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 66692009722 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692009723 peptide binding site [polypeptide binding]; other site 66692009724 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692009725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009726 dimer interface [polypeptide binding]; other site 66692009727 conserved gate region; other site 66692009728 putative PBP binding loops; other site 66692009729 ABC-ATPase subunit interface; other site 66692009730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692009731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009732 dimer interface [polypeptide binding]; other site 66692009733 conserved gate region; other site 66692009734 putative PBP binding loops; other site 66692009735 ABC-ATPase subunit interface; other site 66692009736 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 66692009737 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692009738 Walker A/P-loop; other site 66692009739 ATP binding site [chemical binding]; other site 66692009740 Q-loop/lid; other site 66692009741 ABC transporter signature motif; other site 66692009742 Walker B; other site 66692009743 D-loop; other site 66692009744 H-loop/switch region; other site 66692009745 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 66692009746 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692009747 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692009748 Walker A/P-loop; other site 66692009749 ATP binding site [chemical binding]; other site 66692009750 Q-loop/lid; other site 66692009751 ABC transporter signature motif; other site 66692009752 Walker B; other site 66692009753 D-loop; other site 66692009754 H-loop/switch region; other site 66692009755 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692009756 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 66692009757 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692009758 putative DNA binding site [nucleotide binding]; other site 66692009759 putative Zn2+ binding site [ion binding]; other site 66692009760 AsnC family; Region: AsnC_trans_reg; pfam01037 66692009761 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 66692009762 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 66692009763 Lysozyme subfamily 2; Region: LYZ2; smart00047 66692009764 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009765 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009766 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009767 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009768 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009769 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009770 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009771 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009772 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009773 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692009774 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 66692009775 Vesicle coat trafficking protein Sec16 N-terminus; Region: Sec16_N; pfam12935 66692009776 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 66692009777 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 66692009778 active site 66692009779 tetramer interface; other site 66692009780 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692009781 active site 66692009782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 66692009783 active site 66692009784 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 66692009785 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 66692009786 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 66692009787 active site 66692009788 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 66692009789 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 66692009790 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 66692009791 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 66692009792 CoA binding domain; Region: CoA_binding; cl17356 66692009793 Bacterial sugar transferase; Region: Bac_transf; pfam02397 66692009794 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 66692009795 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 66692009796 Ligand binding site; other site 66692009797 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 66692009798 active site 66692009799 catalytic triad [active] 66692009800 oxyanion hole [active] 66692009801 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 66692009802 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 66692009803 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 66692009804 Class I ribonucleotide reductase; Region: RNR_I; cd01679 66692009805 active site 66692009806 dimer interface [polypeptide binding]; other site 66692009807 catalytic residues [active] 66692009808 effector binding site; other site 66692009809 R2 peptide binding site; other site 66692009810 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 66692009811 dimer interface [polypeptide binding]; other site 66692009812 putative radical transfer pathway; other site 66692009813 diiron center [ion binding]; other site 66692009814 tyrosyl radical; other site 66692009815 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 66692009816 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 66692009817 catalytic triad [active] 66692009818 conserved cis-peptide bond; other site 66692009819 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 66692009820 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692009821 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692009822 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 66692009823 active site 66692009824 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 66692009825 classical (c) SDRs; Region: SDR_c; cd05233 66692009826 NAD(P) binding site [chemical binding]; other site 66692009827 active site 66692009828 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 66692009829 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 66692009830 substrate binding [chemical binding]; other site 66692009831 active site 66692009832 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 66692009833 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 66692009834 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 66692009835 active site 66692009836 substrate binding [chemical binding]; other site 66692009837 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 66692009838 Bacterial Ig-like domain 2; Region: BID_2; smart00635 66692009839 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692009840 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692009841 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692009842 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009843 dimer interface [polypeptide binding]; other site 66692009844 conserved gate region; other site 66692009845 putative PBP binding loops; other site 66692009846 ABC-ATPase subunit interface; other site 66692009847 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692009848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009849 dimer interface [polypeptide binding]; other site 66692009850 conserved gate region; other site 66692009851 putative PBP binding loops; other site 66692009852 ABC-ATPase subunit interface; other site 66692009853 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692009854 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692009855 DNA binding site [nucleotide binding] 66692009856 domain linker motif; other site 66692009857 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 66692009858 dimerization interface [polypeptide binding]; other site 66692009859 ligand binding site [chemical binding]; other site 66692009860 sodium binding site [ion binding]; other site 66692009861 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 66692009862 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 66692009863 Walker A/P-loop; other site 66692009864 ATP binding site [chemical binding]; other site 66692009865 Q-loop/lid; other site 66692009866 ABC transporter signature motif; other site 66692009867 Walker B; other site 66692009868 D-loop; other site 66692009869 H-loop/switch region; other site 66692009870 TOBE domain; Region: TOBE_2; pfam08402 66692009871 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692009872 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009873 dimer interface [polypeptide binding]; other site 66692009874 conserved gate region; other site 66692009875 putative PBP binding loops; other site 66692009876 ABC-ATPase subunit interface; other site 66692009877 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692009878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692009879 dimer interface [polypeptide binding]; other site 66692009880 conserved gate region; other site 66692009881 putative PBP binding loops; other site 66692009882 ABC-ATPase subunit interface; other site 66692009883 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692009884 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692009885 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 66692009886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692009887 non-specific DNA binding site [nucleotide binding]; other site 66692009888 salt bridge; other site 66692009889 sequence-specific DNA binding site [nucleotide binding]; other site 66692009890 Uncharacterized conserved protein [Function unknown]; Region: COG1432 66692009891 LabA_like proteins; Region: LabA_like; cd06167 66692009892 putative metal binding site [ion binding]; other site 66692009893 Predicted transcriptional regulators [Transcription]; Region: COG1725 66692009894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 66692009895 DNA-binding site [nucleotide binding]; DNA binding site 66692009896 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 66692009897 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692009898 Walker A/P-loop; other site 66692009899 ATP binding site [chemical binding]; other site 66692009900 Q-loop/lid; other site 66692009901 ABC transporter signature motif; other site 66692009902 Walker B; other site 66692009903 D-loop; other site 66692009904 H-loop/switch region; other site 66692009905 Entner-Doudoroff aldolase; Region: eda; TIGR01182 66692009906 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 66692009907 active site 66692009908 intersubunit interface [polypeptide binding]; other site 66692009909 catalytic residue [active] 66692009910 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 66692009911 Predicted transcriptional regulator [Transcription]; Region: COG1959 66692009912 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692009913 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 66692009914 active site 66692009915 ATP binding site [chemical binding]; other site 66692009916 GAF domain; Region: GAF_2; pfam13185 66692009917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692009918 Histidine kinase; Region: HisKA_3; pfam07730 66692009919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692009920 ATP binding site [chemical binding]; other site 66692009921 Mg2+ binding site [ion binding]; other site 66692009922 G-X-G motif; other site 66692009923 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692009924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692009925 active site 66692009926 phosphorylation site [posttranslational modification] 66692009927 intermolecular recognition site; other site 66692009928 dimerization interface [polypeptide binding]; other site 66692009929 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692009930 DNA binding residues [nucleotide binding] 66692009931 dimerization interface [polypeptide binding]; other site 66692009932 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 66692009933 active site 66692009934 S-adenosylmethionine:tRNA-ribosyltransferase- isomerase (queuine synthetase) [Translation, ribosomal structure and biogenesis]; Region: QueA; COG0809 66692009935 short chain dehydrogenase; Region: adh_short; pfam00106 66692009936 classical (c) SDRs; Region: SDR_c; cd05233 66692009937 NAD(P) binding site [chemical binding]; other site 66692009938 active site 66692009939 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 66692009940 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 66692009941 Predicted transcriptional regulator [Transcription]; Region: COG2378 66692009942 HTH domain; Region: HTH_11; pfam08279 66692009943 WYL domain; Region: WYL; pfam13280 66692009944 DinB family; Region: DinB; cl17821 66692009945 sugar phosphate phosphatase; Provisional; Region: PRK10513 66692009946 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692009947 active site 66692009948 motif I; other site 66692009949 motif II; other site 66692009950 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 66692009951 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 66692009952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692009953 active site 66692009954 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692009955 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692009956 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692009957 Immunity protein Imm1; Region: Imm1; pfam14430 66692009958 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 66692009959 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 66692009960 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 66692009961 minor groove reading motif; other site 66692009962 helix-hairpin-helix signature motif; other site 66692009963 substrate binding pocket [chemical binding]; other site 66692009964 active site 66692009965 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 66692009966 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 66692009967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692009968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692009969 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 66692009970 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 66692009971 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 66692009972 DNA binding site [nucleotide binding] 66692009973 active site 66692009974 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692009975 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 66692009976 CsbD-like; Region: CsbD; pfam05532 66692009977 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692009978 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692009979 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 66692009980 Mg++ binding site [ion binding]; other site 66692009981 putative catalytic motif [active] 66692009982 substrate binding site [chemical binding]; other site 66692009983 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692009984 active site 66692009985 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 66692009986 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 66692009987 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 66692009988 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 66692009989 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 66692009990 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 66692009991 putative ADP-binding pocket [chemical binding]; other site 66692009992 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 66692009993 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692009994 active site 66692009995 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 66692009996 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 66692009997 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 66692009998 Predicted transcriptional regulator [Transcription]; Region: COG2345 66692009999 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692010000 putative DNA binding site [nucleotide binding]; other site 66692010001 putative Zn2+ binding site [ion binding]; other site 66692010002 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 66692010003 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 66692010004 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 66692010005 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 66692010006 4Fe-4S binding domain; Region: Fer4; pfam00037 66692010007 Transposase IS200 like; Region: Y1_Tnp; pfam01797 66692010008 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692010009 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 66692010010 putative metal binding site [ion binding]; other site 66692010011 dimer interface [polypeptide binding]; other site 66692010012 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 66692010013 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 66692010014 amidohydrolase; Region: amidohydrolases; TIGR01891 66692010015 putative metal binding site [ion binding]; other site 66692010016 Predicted transcriptional regulator [Transcription]; Region: COG2345 66692010017 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 66692010018 active site 66692010019 zinc binding site [ion binding]; other site 66692010020 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 66692010021 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 66692010022 homodimer interface [polypeptide binding]; other site 66692010023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692010024 catalytic residue [active] 66692010025 Biotin-lipoyl like; Region: Biotin_lipoyl_2; cl19169 66692010026 HlyD family secretion protein; Region: HlyD_3; pfam13437 66692010027 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 66692010028 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692010029 Walker A/P-loop; other site 66692010030 ATP binding site [chemical binding]; other site 66692010031 Q-loop/lid; other site 66692010032 ABC transporter signature motif; other site 66692010033 Walker B; other site 66692010034 D-loop; other site 66692010035 H-loop/switch region; other site 66692010036 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 66692010037 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 66692010038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692010039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692010040 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 66692010041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692010042 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692010043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692010044 dimerization interface [polypeptide binding]; other site 66692010045 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 66692010046 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 66692010047 tetramer interfaces [polypeptide binding]; other site 66692010048 binuclear metal-binding site [ion binding]; other site 66692010049 Sm and related proteins; Region: Sm_like; cl00259 66692010050 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692010051 intersubunit interface [polypeptide binding]; other site 66692010052 active site 66692010053 zinc binding site [ion binding]; other site 66692010054 Na+ binding site [ion binding]; other site 66692010055 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692010056 active site 66692010057 phosphorylation site [posttranslational modification] 66692010058 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 66692010059 active site 66692010060 P-loop; other site 66692010061 phosphorylation site [posttranslational modification] 66692010062 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 66692010063 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 66692010064 putative substrate binding site [chemical binding]; other site 66692010065 putative ATP binding site [chemical binding]; other site 66692010066 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 66692010067 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 66692010068 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692010069 putative active site [active] 66692010070 universal stress protein UspE; Provisional; Region: PRK11175 66692010071 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 66692010072 Ligand Binding Site [chemical binding]; other site 66692010073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 66692010074 Ligand Binding Site [chemical binding]; other site 66692010075 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 66692010076 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 66692010077 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 66692010078 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 66692010079 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 66692010080 active site 66692010081 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010083 dimer interface [polypeptide binding]; other site 66692010084 conserved gate region; other site 66692010085 putative PBP binding loops; other site 66692010086 ABC-ATPase subunit interface; other site 66692010087 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692010088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010089 dimer interface [polypeptide binding]; other site 66692010090 conserved gate region; other site 66692010091 putative PBP binding loops; other site 66692010092 ABC-ATPase subunit interface; other site 66692010093 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 66692010094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692010095 Walker A/P-loop; other site 66692010096 ATP binding site [chemical binding]; other site 66692010097 Q-loop/lid; other site 66692010098 ABC transporter signature motif; other site 66692010099 Walker B; other site 66692010100 D-loop; other site 66692010101 H-loop/switch region; other site 66692010102 TOBE domain; Region: TOBE_2; pfam08402 66692010103 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 66692010104 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692010105 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692010106 active site 66692010107 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 66692010108 Inner spore coat protein D; Region: Spore-coat_CotD; pfam11122 66692010109 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010111 dimer interface [polypeptide binding]; other site 66692010112 conserved gate region; other site 66692010113 putative PBP binding loops; other site 66692010114 ABC-ATPase subunit interface; other site 66692010115 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692010116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010117 dimer interface [polypeptide binding]; other site 66692010118 conserved gate region; other site 66692010119 putative PBP binding loops; other site 66692010120 ABC-ATPase subunit interface; other site 66692010121 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692010122 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692010123 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 66692010124 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 66692010125 active site 66692010126 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 66692010127 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 66692010128 Sulfatase; Region: Sulfatase; pfam00884 66692010129 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692010130 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 66692010131 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692010132 galactokinase; Provisional; Region: PRK05322 66692010133 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 66692010134 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 66692010135 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 66692010136 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 66692010137 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 66692010138 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 66692010139 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 66692010140 HEAT repeats; Region: HEAT_2; pfam13646 66692010141 HEAT repeats; Region: HEAT_2; pfam13646 66692010142 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692010143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692010144 putative substrate translocation pore; other site 66692010145 M20 Peptidase Arginine utilization protein, RocB; Region: M20_ArgE_RocB; cd05654 66692010146 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 66692010147 putative metal binding site [ion binding]; other site 66692010148 putative dimer interface [polypeptide binding]; other site 66692010149 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692010150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692010151 nucleotide binding site [chemical binding]; other site 66692010152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692010153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692010154 active site 66692010155 phosphorylation site [posttranslational modification] 66692010156 intermolecular recognition site; other site 66692010157 dimerization interface [polypeptide binding]; other site 66692010158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692010159 DNA binding site [nucleotide binding] 66692010160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692010161 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 66692010162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692010163 ATP binding site [chemical binding]; other site 66692010164 Mg2+ binding site [ion binding]; other site 66692010165 G-X-G motif; other site 66692010166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692010167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692010168 Walker A/P-loop; other site 66692010169 ATP binding site [chemical binding]; other site 66692010170 Q-loop/lid; other site 66692010171 ABC transporter signature motif; other site 66692010172 Walker B; other site 66692010173 D-loop; other site 66692010174 H-loop/switch region; other site 66692010175 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 66692010176 FtsX-like permease family; Region: FtsX; pfam02687 66692010177 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 66692010178 metal-binding site [ion binding] 66692010179 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 66692010180 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 66692010181 metal-binding site [ion binding] 66692010182 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 66692010183 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 66692010184 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 66692010185 catalytic residue [active] 66692010186 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692010187 motif II; other site 66692010188 CAAX protease self-immunity; Region: Abi; pfam02517 66692010189 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 66692010190 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692010191 dimerization interface [polypeptide binding]; other site 66692010192 putative DNA binding site [nucleotide binding]; other site 66692010193 putative Zn2+ binding site [ion binding]; other site 66692010194 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 66692010195 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 66692010196 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 66692010197 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 66692010198 Nucleoside recognition; Region: Gate; pfam07670 66692010199 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 66692010200 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 66692010201 Glucitol operon activator protein (GutM); Region: GutM; cl01890 66692010202 Predicted homoserine dehydrogenase [Amino acid transport and metabolism]; Region: COG4091 66692010203 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 66692010204 SAF domain of putative dehydrogenases or oxidoreductases; Region: SAF_DH_OX_like; cd11616 66692010205 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 66692010206 dimerization domain swap beta strand [polypeptide binding]; other site 66692010207 regulatory protein interface [polypeptide binding]; other site 66692010208 active site 66692010209 regulatory phosphorylation site [posttranslational modification]; other site 66692010210 Predicted integral membrane protein [Function unknown]; Region: COG5652 66692010211 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692010212 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 66692010213 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 66692010214 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692010215 Coenzyme A binding pocket [chemical binding]; other site 66692010216 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692010217 NMT1-like family; Region: NMT1_2; cl17432 66692010218 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 66692010219 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692010220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010221 dimer interface [polypeptide binding]; other site 66692010222 conserved gate region; other site 66692010223 putative PBP binding loops; other site 66692010224 ABC-ATPase subunit interface; other site 66692010225 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 66692010226 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692010227 Walker A/P-loop; other site 66692010228 ATP binding site [chemical binding]; other site 66692010229 Q-loop/lid; other site 66692010230 ABC transporter signature motif; other site 66692010231 Walker B; other site 66692010232 D-loop; other site 66692010233 H-loop/switch region; other site 66692010234 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 66692010235 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692010236 Cysteine-rich domain; Region: CCG; pfam02754 66692010237 Cysteine-rich domain; Region: CCG; pfam02754 66692010238 FAD binding domain; Region: FAD_binding_4; pfam01565 66692010239 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 66692010240 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 66692010241 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 66692010242 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 66692010243 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692010244 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 66692010245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692010246 putative substrate translocation pore; other site 66692010247 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 66692010248 Tetratricopeptide repeat; Region: TPR_16; pfam13432 66692010249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692010250 binding surface 66692010251 TPR motif; other site 66692010252 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692010253 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 66692010254 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 66692010255 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 66692010256 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 66692010257 acyl-activating enzyme (AAE) consensus motif; other site 66692010258 AMP binding site [chemical binding]; other site 66692010259 active site 66692010260 CoA binding site [chemical binding]; other site 66692010261 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 66692010262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692010263 NAD(P) binding site [chemical binding]; other site 66692010264 active site 66692010265 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 66692010266 putative active site; other site 66692010267 putative triphosphate binding site [ion binding]; other site 66692010268 signature motif; other site 66692010269 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 66692010270 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 66692010271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010272 dimer interface [polypeptide binding]; other site 66692010273 conserved gate region; other site 66692010274 putative PBP binding loops; other site 66692010275 ABC-ATPase subunit interface; other site 66692010276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010277 dimer interface [polypeptide binding]; other site 66692010278 conserved gate region; other site 66692010279 putative PBP binding loops; other site 66692010280 ABC-ATPase subunit interface; other site 66692010281 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 66692010282 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 66692010283 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692010284 Walker A/P-loop; other site 66692010285 ATP binding site [chemical binding]; other site 66692010286 Q-loop/lid; other site 66692010287 ABC transporter signature motif; other site 66692010288 Walker B; other site 66692010289 D-loop; other site 66692010290 H-loop/switch region; other site 66692010291 TOBE domain; Region: TOBE_2; pfam08402 66692010292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692010293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692010294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 66692010295 dimerization interface [polypeptide binding]; other site 66692010296 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 66692010297 HAD-hyrolase-like; Region: Hydrolase_like; cl19142 66692010298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692010299 motif II; other site 66692010300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692010301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692010302 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 66692010303 EamA-like transporter family; Region: EamA; pfam00892 66692010304 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 66692010305 EamA-like transporter family; Region: EamA; pfam00892 66692010306 Right handed beta helix region; Region: Beta_helix; pfam13229 66692010307 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 66692010308 nudix motif; other site 66692010309 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 66692010310 Transposase, Mutator family; Region: Transposase_mut; cl19537 66692010311 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692010312 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692010313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010315 dimer interface [polypeptide binding]; other site 66692010316 conserved gate region; other site 66692010317 putative PBP binding loops; other site 66692010318 ABC-ATPase subunit interface; other site 66692010319 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692010320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010321 dimer interface [polypeptide binding]; other site 66692010322 conserved gate region; other site 66692010323 putative PBP binding loops; other site 66692010324 ABC-ATPase subunit interface; other site 66692010325 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 66692010326 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692010327 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692010328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010330 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010331 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692010332 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010334 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; cl19130 66692010335 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010336 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692010337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010339 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692010340 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692010341 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010343 dimer interface [polypeptide binding]; other site 66692010344 conserved gate region; other site 66692010345 putative PBP binding loops; other site 66692010346 ABC-ATPase subunit interface; other site 66692010347 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692010348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010349 dimer interface [polypeptide binding]; other site 66692010350 conserved gate region; other site 66692010351 putative PBP binding loops; other site 66692010352 ABC-ATPase subunit interface; other site 66692010353 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692010354 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692010355 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010356 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692010357 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010358 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692010359 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692010360 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 66692010361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692010363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010364 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010365 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692010366 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010367 Protein of unknown function, DUF393; Region: DUF393; pfam04134 66692010368 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 66692010369 phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654 66692010370 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660 66692010371 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 66692010372 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 66692010373 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 66692010374 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692010375 catalytic residue [active] 66692010376 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 66692010377 Sulfatase; Region: Sulfatase; pfam00884 66692010378 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 66692010379 active site 66692010380 metal binding site [ion binding]; metal-binding site 66692010381 Bacterial SH3 domain; Region: SH3_3; pfam08239 66692010382 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 66692010383 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 66692010384 active site 66692010385 metal binding site [ion binding]; metal-binding site 66692010386 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5504 66692010387 heat shock protein HtpX; Provisional; Region: PRK05457 66692010388 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 66692010389 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 66692010390 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 66692010391 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010393 dimer interface [polypeptide binding]; other site 66692010394 conserved gate region; other site 66692010395 putative PBP binding loops; other site 66692010396 ABC-ATPase subunit interface; other site 66692010397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010398 dimer interface [polypeptide binding]; other site 66692010399 conserved gate region; other site 66692010400 putative PBP binding loops; other site 66692010401 ABC-ATPase subunit interface; other site 66692010402 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692010403 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 66692010404 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692010405 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 66692010406 AzlC protein; Region: AzlC; cl00570 66692010407 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692010408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692010409 non-specific DNA binding site [nucleotide binding]; other site 66692010410 salt bridge; other site 66692010411 sequence-specific DNA binding site [nucleotide binding]; other site 66692010412 Cupin domain; Region: Cupin_2; pfam07883 66692010413 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692010414 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692010415 Coenzyme A binding pocket [chemical binding]; other site 66692010416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692010417 S-adenosylmethionine binding site [chemical binding]; other site 66692010418 Predicted membrane protein [Function unknown]; Region: COG2261 66692010419 histidyl-tRNA synthetase; Provisional; Region: PRK12420 66692010420 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 66692010421 dimer interface [polypeptide binding]; other site 66692010422 motif 1; other site 66692010423 active site 66692010424 motif 2; other site 66692010425 motif 3; other site 66692010426 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 66692010427 anticodon binding site; other site 66692010428 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 66692010429 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692010430 Zn2+ binding site [ion binding]; other site 66692010431 Mg2+ binding site [ion binding]; other site 66692010432 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 66692010433 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 66692010434 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 66692010435 Protein of unknown function (DUF917); Region: DUF917; pfam06032 66692010436 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 66692010437 Na binding site [ion binding]; other site 66692010438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692010439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692010440 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 66692010441 stage II sporulation protein P; Region: spore_II_P; TIGR02867 66692010442 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 66692010443 active site 66692010444 ATP binding site [chemical binding]; other site 66692010445 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 66692010446 substrate binding site [chemical binding]; other site 66692010447 activation loop (A-loop); other site 66692010448 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 66692010449 nucleotide binding site/active site [active] 66692010450 HIT family signature motif; other site 66692010451 catalytic residue [active] 66692010452 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 66692010453 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692010454 Zn2+ binding site [ion binding]; other site 66692010455 Mg2+ binding site [ion binding]; other site 66692010456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692010457 binding surface 66692010458 TPR motif; other site 66692010459 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692010460 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 66692010461 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692010462 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 66692010463 Nucleoside recognition; Region: Gate; pfam07670 66692010464 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 66692010465 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 66692010466 active site 66692010467 putative substrate binding pocket [chemical binding]; other site 66692010468 allantoate amidohydrolase; Reviewed; Region: PRK12890 66692010469 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 66692010470 active site 66692010471 metal binding site [ion binding]; metal-binding site 66692010472 dimer interface [polypeptide binding]; other site 66692010473 imidazolonepropionase; Validated; Region: PRK09356 66692010474 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 66692010475 active site 66692010476 urocanate hydratase; Provisional; Region: PRK05414 66692010477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692010478 active site 66692010479 phosphorylation site [posttranslational modification] 66692010480 intermolecular recognition site; other site 66692010481 dimerization interface [polypeptide binding]; other site 66692010482 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692010483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692010485 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692010486 putative substrate translocation pore; other site 66692010487 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 66692010488 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 66692010489 Histidine kinase; Region: HisKA_3; pfam07730 66692010490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692010491 ATP binding site [chemical binding]; other site 66692010492 Mg2+ binding site [ion binding]; other site 66692010493 G-X-G motif; other site 66692010494 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692010495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692010496 active site 66692010497 phosphorylation site [posttranslational modification] 66692010498 intermolecular recognition site; other site 66692010499 dimerization interface [polypeptide binding]; other site 66692010500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692010501 DNA binding residues [nucleotide binding] 66692010502 dimerization interface [polypeptide binding]; other site 66692010503 YfzA-like protein; Region: YfzA; pfam14118 66692010504 transcriptional antiterminator BglG; Provisional; Region: PRK09772 66692010505 CAT RNA binding domain; Region: CAT_RBD; smart01061 66692010506 PRD domain; Region: PRD; pfam00874 66692010507 PRD domain; Region: PRD; pfam00874 66692010508 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 66692010509 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692010510 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692010511 active site turn [active] 66692010512 phosphorylation site [posttranslational modification] 66692010513 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 66692010514 dimer interface [polypeptide binding]; other site 66692010515 catalytic triad [active] 66692010516 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 66692010517 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 66692010518 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 66692010519 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692010520 ABC transporter; Region: ABC_tran_2; pfam12848 66692010521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 66692010522 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692010523 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 66692010524 putative NAD(P) binding site [chemical binding]; other site 66692010525 catalytic Zn binding site [ion binding]; other site 66692010526 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692010527 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 66692010528 putative NAD(P) binding site [chemical binding]; other site 66692010529 catalytic Zn binding site [ion binding]; other site 66692010530 structural Zn binding site [ion binding]; other site 66692010531 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 66692010532 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 66692010533 active site 66692010534 P-loop; other site 66692010535 phosphorylation site [posttranslational modification] 66692010536 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692010537 active site 66692010538 phosphorylation site [posttranslational modification] 66692010539 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692010540 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692010541 PRD domain; Region: PRD; pfam00874 66692010542 PRD domain; Region: PRD; pfam00874 66692010543 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692010544 active site 66692010545 P-loop; other site 66692010546 phosphorylation site [posttranslational modification] 66692010547 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692010548 active site 66692010549 phosphorylation site [posttranslational modification] 66692010550 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 66692010551 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 66692010552 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 66692010553 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 66692010554 active site 66692010555 dimer interface [polypeptide binding]; other site 66692010556 magnesium binding site [ion binding]; other site 66692010557 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 66692010558 substrate binding site [chemical binding]; other site 66692010559 ATP binding site [chemical binding]; other site 66692010560 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 66692010561 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692010562 active site 66692010563 dimer interface [polypeptide binding]; other site 66692010564 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 66692010565 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 66692010566 tetramer interface [polypeptide binding]; other site 66692010567 active site 66692010568 DctM-like transporters; Region: DctM; pfam06808 66692010569 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692010570 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692010571 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692010572 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692010573 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692010574 DNA binding site [nucleotide binding] 66692010575 domain linker motif; other site 66692010576 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 66692010577 putative dimerization interface [polypeptide binding]; other site 66692010578 putative ligand binding site [chemical binding]; other site 66692010579 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692010580 2TM domain; Region: 2TM; pfam13239 66692010581 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 66692010582 oligomer interface [polypeptide binding]; other site 66692010583 active site 66692010584 metal binding site [ion binding]; metal-binding site 66692010585 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cd11523 66692010586 metal binding site [ion binding]; metal-binding site 66692010587 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 66692010588 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 66692010589 Walker A/P-loop; other site 66692010590 ATP binding site [chemical binding]; other site 66692010591 Q-loop/lid; other site 66692010592 ABC transporter signature motif; other site 66692010593 Walker B; other site 66692010594 D-loop; other site 66692010595 H-loop/switch region; other site 66692010596 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 66692010597 Predicted acetyltransferase [General function prediction only]; Region: COG3393 66692010598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692010599 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 66692010600 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 66692010601 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 66692010602 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 66692010603 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692010604 motif II; other site 66692010605 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 66692010606 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 66692010607 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 66692010608 substrate binding site [chemical binding]; other site 66692010609 active site 66692010610 Acyl transferase domain; Region: Acyl_transf_1; cl08282 66692010611 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 66692010612 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 66692010613 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 66692010614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010615 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 66692010616 dimer interface [polypeptide binding]; other site 66692010617 conserved gate region; other site 66692010618 putative PBP binding loops; other site 66692010619 ABC-ATPase subunit interface; other site 66692010620 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692010621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692010622 active site 66692010623 phosphorylation site [posttranslational modification] 66692010624 intermolecular recognition site; other site 66692010625 dimerization interface [polypeptide binding]; other site 66692010626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692010627 DNA binding residues [nucleotide binding] 66692010628 dimerization interface [polypeptide binding]; other site 66692010629 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 66692010630 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692010631 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 66692010632 Histidine kinase; Region: HisKA_3; pfam07730 66692010633 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692010634 ATP binding site [chemical binding]; other site 66692010635 Mg2+ binding site [ion binding]; other site 66692010636 G-X-G motif; other site 66692010637 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 66692010638 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 66692010639 Cupin; Region: Cupin_1; smart00835 66692010640 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 66692010641 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692010642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692010643 DNA binding site [nucleotide binding] 66692010644 domain linker motif; other site 66692010645 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 66692010646 dimerization interface [polypeptide binding]; other site 66692010647 ligand binding site [chemical binding]; other site 66692010648 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 66692010649 amphipathic channel; other site 66692010650 Asn-Pro-Ala signature motifs; other site 66692010651 glycerol kinase; Provisional; Region: glpK; PRK00047 66692010652 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 66692010653 N- and C-terminal domain interface [polypeptide binding]; other site 66692010654 active site 66692010655 MgATP binding site [chemical binding]; other site 66692010656 catalytic site [active] 66692010657 metal binding site [ion binding]; metal-binding site 66692010658 glycerol binding site [chemical binding]; other site 66692010659 homotetramer interface [polypeptide binding]; other site 66692010660 homodimer interface [polypeptide binding]; other site 66692010661 FBP binding site [chemical binding]; other site 66692010662 protein IIAGlc interface [polypeptide binding]; other site 66692010663 short chain dehydrogenase; Provisional; Region: PRK08303 66692010664 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 66692010665 NAD(P) binding site [chemical binding]; other site 66692010666 active site 66692010667 Predicted transcriptional regulator [Transcription]; Region: COG2378 66692010668 Transcriptional regulator; Region: Rrf2; cl17282 66692010669 HTH domain; Region: HTH_11; pfam08279 66692010670 WYL domain; Region: WYL; pfam13280 66692010671 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 66692010672 E-class dimer interface [polypeptide binding]; other site 66692010673 P-class dimer interface [polypeptide binding]; other site 66692010674 active site 66692010675 Cu2+ binding site [ion binding]; other site 66692010676 Zn2+ binding site [ion binding]; other site 66692010677 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 66692010678 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 66692010679 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 66692010680 homodimer interface [polypeptide binding]; other site 66692010681 NADP binding site [chemical binding]; other site 66692010682 substrate binding site [chemical binding]; other site 66692010683 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 66692010684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692010685 dimerization interface [polypeptide binding]; other site 66692010686 putative DNA binding site [nucleotide binding]; other site 66692010687 putative Zn2+ binding site [ion binding]; other site 66692010688 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692010689 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692010690 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 66692010691 putative dimerization interface [polypeptide binding]; other site 66692010692 glutamate dehydrogenase; Provisional; Region: PRK09414 66692010693 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 66692010694 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 66692010695 NAD(P) binding site [chemical binding]; other site 66692010696 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692010697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010698 dimer interface [polypeptide binding]; other site 66692010699 conserved gate region; other site 66692010700 putative PBP binding loops; other site 66692010701 ABC-ATPase subunit interface; other site 66692010702 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692010703 substrate binding pocket [chemical binding]; other site 66692010704 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 66692010705 membrane-bound complex binding site; other site 66692010706 hinge residues; other site 66692010707 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 66692010708 active site 66692010709 dimer interface [polypeptide binding]; other site 66692010710 non-prolyl cis peptide bond; other site 66692010711 insertion regions; other site 66692010712 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 66692010713 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692010714 Walker A/P-loop; other site 66692010715 ATP binding site [chemical binding]; other site 66692010716 Q-loop/lid; other site 66692010717 ABC transporter signature motif; other site 66692010718 Walker B; other site 66692010719 D-loop; other site 66692010720 H-loop/switch region; other site 66692010721 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 66692010722 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 66692010723 active site 66692010724 non-prolyl cis peptide bond; other site 66692010725 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 66692010726 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 66692010727 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692010728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692010729 dimerization interface [polypeptide binding]; other site 66692010730 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 66692010731 Cu(I) binding site [ion binding]; other site 66692010732 Predicted membrane protein [Function unknown]; Region: COG2323 66692010733 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 66692010734 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 66692010735 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 66692010736 MMPL family; Region: MMPL; cl14618 66692010737 MMPL family; Region: MMPL; cl14618 66692010738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692010739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692010740 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692010741 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692010742 Walker A/P-loop; other site 66692010743 ATP binding site [chemical binding]; other site 66692010744 Q-loop/lid; other site 66692010745 ABC transporter signature motif; other site 66692010746 Walker B; other site 66692010747 D-loop; other site 66692010748 H-loop/switch region; other site 66692010749 Predicted transcriptional regulators [Transcription]; Region: COG1725 66692010750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692010751 DNA-binding site [nucleotide binding]; DNA binding site 66692010752 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692010753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692010754 S-adenosylmethionine binding site [chemical binding]; other site 66692010755 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 66692010756 active site 66692010757 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 66692010758 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692010759 NAD(P) binding site [chemical binding]; other site 66692010760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 66692010761 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 66692010762 dimanganese center [ion binding]; other site 66692010763 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 66692010764 Predicted membrane protein [Function unknown]; Region: COG4325 66692010765 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 66692010766 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 66692010767 Domain of unknown function DUF21; Region: DUF21; pfam01595 66692010768 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 66692010769 Transporter associated domain; Region: CorC_HlyC; pfam03471 66692010770 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 66692010771 active site 66692010772 catalytic site [active] 66692010773 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 66692010774 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 66692010775 Walker A/P-loop; other site 66692010776 ATP binding site [chemical binding]; other site 66692010777 Q-loop/lid; other site 66692010778 ABC transporter signature motif; other site 66692010779 Walker B; other site 66692010780 D-loop; other site 66692010781 H-loop/switch region; other site 66692010782 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692010783 ABC-ATPase subunit interface; other site 66692010784 dimer interface [polypeptide binding]; other site 66692010785 putative PBP binding regions; other site 66692010786 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 66692010787 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692010788 intersubunit interface [polypeptide binding]; other site 66692010789 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 66692010790 heme-binding site [chemical binding]; other site 66692010791 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 66692010792 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 66692010793 heme-binding site [chemical binding]; other site 66692010794 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 66692010795 heme-binding site [chemical binding]; other site 66692010796 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 66692010797 heme-binding site [chemical binding]; other site 66692010798 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 66692010799 heme uptake protein IsdC; Region: IsdC; TIGR03656 66692010800 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 66692010801 heme-binding site [chemical binding]; other site 66692010802 sortase B cell surface sorting signal; Region: srtB_target; TIGR03063 66692010803 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 66692010804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692010805 ABC-ATPase subunit interface; other site 66692010806 dimer interface [polypeptide binding]; other site 66692010807 putative PBP binding regions; other site 66692010808 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692010809 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692010810 intersubunit interface [polypeptide binding]; other site 66692010811 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 66692010812 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692010813 NAD binding site [chemical binding]; other site 66692010814 catalytic Zn binding site [ion binding]; other site 66692010815 structural Zn binding site [ion binding]; other site 66692010816 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692010817 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692010818 S-adenosylmethionine binding site [chemical binding]; other site 66692010819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692010820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692010821 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 66692010822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692010823 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692010824 putative substrate translocation pore; other site 66692010825 Transposase IS200 like; Region: Y1_Tnp; pfam01797 66692010826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692010827 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692010828 putative substrate translocation pore; other site 66692010829 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 66692010830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692010831 NAD(P) binding site [chemical binding]; other site 66692010832 active site 66692010833 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692010834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692010835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 66692010836 dimerization interface [polypeptide binding]; other site 66692010837 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 66692010838 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692010839 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692010840 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692010841 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010842 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692010843 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692010846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010847 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010849 dimer interface [polypeptide binding]; other site 66692010850 conserved gate region; other site 66692010851 putative PBP binding loops; other site 66692010852 ABC-ATPase subunit interface; other site 66692010853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010854 dimer interface [polypeptide binding]; other site 66692010855 conserved gate region; other site 66692010856 putative PBP binding loops; other site 66692010857 ABC-ATPase subunit interface; other site 66692010858 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692010859 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692010860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692010861 putative DNA binding site [nucleotide binding]; other site 66692010862 dimerization interface [polypeptide binding]; other site 66692010863 putative Zn2+ binding site [ion binding]; other site 66692010864 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692010865 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692010866 nucleotide binding site [chemical binding]; other site 66692010867 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 66692010868 Predicted membrane protein [Function unknown]; Region: COG2311 66692010869 Protein of unknown function (DUF418); Region: DUF418; pfam04235 66692010870 YolD-like protein; Region: YolD; pfam08863 66692010871 Mga helix-turn-helix domain; Region: Mga; pfam05043 66692010872 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 66692010873 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 66692010874 active site 66692010875 metal binding site [ion binding]; metal-binding site 66692010876 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 66692010877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692010878 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 66692010879 Walker A motif; other site 66692010880 ATP binding site [chemical binding]; other site 66692010881 Walker B motif; other site 66692010882 arginine finger; other site 66692010883 UvrB/uvrC motif; Region: UVR; pfam02151 66692010884 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692010885 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 66692010886 Walker A motif; other site 66692010887 ATP binding site [chemical binding]; other site 66692010888 Walker B motif; other site 66692010889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 66692010890 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 66692010891 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 66692010892 active site 66692010893 Zn binding site [ion binding]; other site 66692010894 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 66692010895 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 66692010896 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 66692010897 Subtilase family; Region: Peptidase_S8; pfam00082 66692010898 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 66692010899 active site 66692010900 catalytic residues [active] 66692010901 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 66692010902 VanW like protein; Region: VanW; pfam04294 66692010903 CAAX protease self-immunity; Region: Abi; pfam02517 66692010904 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692010905 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692010906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692010907 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 66692010908 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 66692010909 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 66692010910 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 66692010911 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 66692010912 Predicted membrane protein [Function unknown]; Region: COG2259 66692010913 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 66692010914 active site 66692010915 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692010916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 66692010917 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 66692010918 DNA binding residues [nucleotide binding] 66692010919 dimerization interface [polypeptide binding]; other site 66692010920 Predicted permeases [General function prediction only]; Region: COG0679 66692010921 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 66692010922 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 66692010923 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 66692010924 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692010925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010926 dimer interface [polypeptide binding]; other site 66692010927 conserved gate region; other site 66692010928 putative PBP binding loops; other site 66692010929 ABC-ATPase subunit interface; other site 66692010930 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692010931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692010932 dimer interface [polypeptide binding]; other site 66692010933 conserved gate region; other site 66692010934 putative PBP binding loops; other site 66692010935 ABC-ATPase subunit interface; other site 66692010936 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692010937 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 66692010938 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 66692010939 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 66692010940 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 66692010941 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692010942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692010943 DNA binding site [nucleotide binding] 66692010944 domain linker motif; other site 66692010945 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 66692010946 ligand binding site [chemical binding]; other site 66692010947 SnoaL-like domain; Region: SnoaL_2; pfam12680 66692010948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692010949 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692010950 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692010951 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 66692010952 putative ligand binding residues [chemical binding]; other site 66692010953 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 66692010954 active site 66692010955 catalytic tetrad [active] 66692010956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692010957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692010958 DNA binding site [nucleotide binding] 66692010959 domain linker motif; other site 66692010960 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 66692010961 dimerization interface [polypeptide binding]; other site 66692010962 ligand binding site [chemical binding]; other site 66692010963 Protoglobin; Region: Protoglobin; pfam11563 66692010964 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692010965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 66692010966 dimer interface [polypeptide binding]; other site 66692010967 putative CheW interface [polypeptide binding]; other site 66692010968 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 66692010969 active site 66692010970 NTP binding site [chemical binding]; other site 66692010971 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 66692010972 metal binding triad [ion binding]; metal-binding site 66692010973 metal binding triad [ion binding]; metal-binding site 66692010974 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 66692010975 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 66692010976 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 66692010977 phosphopeptide binding site; other site 66692010978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 66692010979 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692010980 DNA binding site [nucleotide binding] 66692010981 allantoate amidohydrolase; Reviewed; Region: PRK09290 66692010982 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 66692010983 active site 66692010984 metal binding site [ion binding]; metal-binding site 66692010985 dimer interface [polypeptide binding]; other site 66692010986 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 66692010987 Putative esterase; Region: Esterase; pfam00756 66692010988 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692010989 ABC-ATPase subunit interface; other site 66692010990 dimer interface [polypeptide binding]; other site 66692010991 putative PBP binding regions; other site 66692010992 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692010993 ABC-ATPase subunit interface; other site 66692010994 dimer interface [polypeptide binding]; other site 66692010995 putative PBP binding regions; other site 66692010996 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692010997 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692010998 intersubunit interface [polypeptide binding]; other site 66692010999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692011001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011002 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692011003 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 66692011004 intersubunit interface [polypeptide binding]; other site 66692011005 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 66692011006 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692011007 Spore germination protein; Region: Spore_permease; cl17796 66692011008 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 66692011009 FtsX-like permease family; Region: FtsX; pfam02687 66692011010 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692011011 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 66692011012 Walker A/P-loop; other site 66692011013 ATP binding site [chemical binding]; other site 66692011014 Q-loop/lid; other site 66692011015 ABC transporter signature motif; other site 66692011016 Walker B; other site 66692011017 D-loop; other site 66692011018 H-loop/switch region; other site 66692011019 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692011020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692011021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011022 dimer interface [polypeptide binding]; other site 66692011023 conserved gate region; other site 66692011024 putative PBP binding loops; other site 66692011025 ABC-ATPase subunit interface; other site 66692011026 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692011027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011028 dimer interface [polypeptide binding]; other site 66692011029 conserved gate region; other site 66692011030 putative PBP binding loops; other site 66692011031 ABC-ATPase subunit interface; other site 66692011032 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692011033 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 66692011034 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 66692011035 active site 66692011036 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 66692011037 PRD domain; Region: PRD; pfam00874 66692011038 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 66692011039 active site 66692011040 P-loop; other site 66692011041 phosphorylation site [posttranslational modification] 66692011042 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692011043 active site 66692011044 phosphorylation site [posttranslational modification] 66692011045 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 66692011046 active site 66692011047 ADP/pyrophosphate binding site [chemical binding]; other site 66692011048 dimerization interface [polypeptide binding]; other site 66692011049 allosteric effector site; other site 66692011050 fructose-1,6-bisphosphate binding site; other site 66692011051 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 66692011052 active site 66692011053 P-loop; other site 66692011054 phosphorylation site [posttranslational modification] 66692011055 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 66692011056 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692011057 intersubunit interface [polypeptide binding]; other site 66692011058 active site 66692011059 zinc binding site [ion binding]; other site 66692011060 Na+ binding site [ion binding]; other site 66692011061 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 66692011062 intracellular protease, PfpI family; Region: PfpI; TIGR01382 66692011063 conserved cys residue [active] 66692011064 General stress protein [General function prediction only]; Region: GsiB; COG3729 66692011065 General stress protein [General function prediction only]; Region: GsiB; COG3729 66692011066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692011067 S-adenosylmethionine binding site [chemical binding]; other site 66692011068 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 66692011069 Zn(II)-responsive transcriptional regulator; Region: ZntR; TIGR02043 66692011070 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 66692011071 DNA binding residues [nucleotide binding] 66692011072 dimer interface [polypeptide binding]; other site 66692011073 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 66692011074 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 66692011075 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 66692011076 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 66692011077 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 66692011078 metal binding site [ion binding]; metal-binding site 66692011079 dimer interface [polypeptide binding]; other site 66692011080 DinB superfamily; Region: DinB_2; pfam12867 66692011081 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 66692011082 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 66692011083 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 66692011084 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 66692011085 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 66692011086 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 66692011087 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692011088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011089 dimer interface [polypeptide binding]; other site 66692011090 conserved gate region; other site 66692011091 putative PBP binding loops; other site 66692011092 ABC-ATPase subunit interface; other site 66692011093 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692011094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011095 dimer interface [polypeptide binding]; other site 66692011096 conserved gate region; other site 66692011097 putative PBP binding loops; other site 66692011098 ABC-ATPase subunit interface; other site 66692011099 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 66692011100 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 66692011101 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692011102 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692011103 DNA binding site [nucleotide binding] 66692011104 domain linker motif; other site 66692011105 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 66692011106 putative dimerization interface [polypeptide binding]; other site 66692011107 putative ligand binding site [chemical binding]; other site 66692011108 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 66692011109 EamA-like transporter family; Region: EamA; pfam00892 66692011110 EamA-like transporter family; Region: EamA; pfam00892 66692011111 Predicted transcriptional regulators [Transcription]; Region: COG1378 66692011112 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 66692011113 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 66692011114 C-terminal domain interface [polypeptide binding]; other site 66692011115 sugar binding site [chemical binding]; other site 66692011116 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 66692011117 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692011118 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692011119 Walker A/P-loop; other site 66692011120 ATP binding site [chemical binding]; other site 66692011121 Q-loop/lid; other site 66692011122 ABC transporter signature motif; other site 66692011123 Walker B; other site 66692011124 D-loop; other site 66692011125 H-loop/switch region; other site 66692011126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692011128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011129 Amidinotransferase; Region: Amidinotransf; cl19186 66692011130 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 66692011131 Na binding site [ion binding]; other site 66692011132 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 66692011133 classical (c) SDRs; Region: SDR_c; cd05233 66692011134 NAD(P) binding site [chemical binding]; other site 66692011135 active site 66692011136 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692011137 dimerization interface [polypeptide binding]; other site 66692011138 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692011139 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 66692011140 dimer interface [polypeptide binding]; other site 66692011141 putative CheW interface [polypeptide binding]; other site 66692011142 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 66692011143 Erythromycin esterase; Region: Erythro_esteras; cl17110 66692011144 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 66692011145 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 66692011146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 66692011147 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 66692011148 Phosphotransferase enzyme family; Region: APH; pfam01636 66692011149 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 66692011150 active site 66692011151 substrate binding site [chemical binding]; other site 66692011152 ATP binding site [chemical binding]; other site 66692011153 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 66692011154 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 66692011155 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692011156 DNA binding residues [nucleotide binding] 66692011157 putative dimer interface [polypeptide binding]; other site 66692011158 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 66692011159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692011160 NAD(P) binding site [chemical binding]; other site 66692011161 active site 66692011162 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 66692011163 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 66692011164 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 66692011165 ligand binding site [chemical binding]; other site 66692011166 dimerization interface [polypeptide binding]; other site 66692011167 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 66692011168 TM-ABC transporter signature motif; other site 66692011169 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 66692011170 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 66692011171 Walker A/P-loop; other site 66692011172 ATP binding site [chemical binding]; other site 66692011173 Q-loop/lid; other site 66692011174 ABC transporter signature motif; other site 66692011175 Walker B; other site 66692011176 D-loop; other site 66692011177 H-loop/switch region; other site 66692011178 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 66692011179 D-ribose pyranase; Provisional; Region: PRK11797 66692011180 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 66692011181 substrate binding site [chemical binding]; other site 66692011182 dimer interface [polypeptide binding]; other site 66692011183 ATP binding site [chemical binding]; other site 66692011184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692011185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692011186 DNA binding site [nucleotide binding] 66692011187 domain linker motif; other site 66692011188 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 66692011189 dimerization interface [polypeptide binding]; other site 66692011190 ligand binding site [chemical binding]; other site 66692011191 sodium binding site [ion binding]; other site 66692011192 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 66692011193 active site 66692011194 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 66692011195 germination protein YpeB; Region: spore_YpeB; TIGR02889 66692011196 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 66692011197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692011198 dimerization interface [polypeptide binding]; other site 66692011199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692011200 dimer interface [polypeptide binding]; other site 66692011201 phosphorylation site [posttranslational modification] 66692011202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692011203 ATP binding site [chemical binding]; other site 66692011204 Mg2+ binding site [ion binding]; other site 66692011205 G-X-G motif; other site 66692011206 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692011207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692011208 active site 66692011209 phosphorylation site [posttranslational modification] 66692011210 intermolecular recognition site; other site 66692011211 dimerization interface [polypeptide binding]; other site 66692011212 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692011213 DNA binding site [nucleotide binding] 66692011214 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 66692011215 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 66692011216 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 66692011217 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692011218 Walker A/P-loop; other site 66692011219 ATP binding site [chemical binding]; other site 66692011220 Q-loop/lid; other site 66692011221 ABC transporter signature motif; other site 66692011222 Walker B; other site 66692011223 D-loop; other site 66692011224 H-loop/switch region; other site 66692011225 Flavoprotein; Region: Flavoprotein; pfam02441 66692011226 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 66692011227 active site 66692011228 zinc binding site [ion binding]; other site 66692011229 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 66692011230 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 66692011231 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 66692011232 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 66692011233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692011234 non-specific DNA binding site [nucleotide binding]; other site 66692011235 salt bridge; other site 66692011236 sequence-specific DNA binding site [nucleotide binding]; other site 66692011237 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692011238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692011239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692011240 Walker A/P-loop; other site 66692011241 ATP binding site [chemical binding]; other site 66692011242 Q-loop/lid; other site 66692011243 ABC transporter signature motif; other site 66692011244 Walker B; other site 66692011245 D-loop; other site 66692011246 H-loop/switch region; other site 66692011247 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 66692011248 dinuclear metal binding motif [ion binding]; other site 66692011249 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 66692011250 non-specific DNA binding site [nucleotide binding]; other site 66692011251 salt bridge; other site 66692011252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 66692011253 sequence-specific DNA binding site [nucleotide binding]; other site 66692011254 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 66692011255 active site 66692011256 catalytic site [active] 66692011257 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 66692011258 Cna protein B-type domain; Region: Cna_B; pfam05738 66692011259 Cna protein B-type domain; Region: Cna_B; pfam05738 66692011260 Cna protein B-type domain; Region: Cna_B; pfam05738 66692011261 Cna protein B-type domain; Region: Cna_B; pfam05738 66692011262 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 66692011263 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692011264 intersubunit interface [polypeptide binding]; other site 66692011265 active site 66692011266 zinc binding site [ion binding]; other site 66692011267 Na+ binding site [ion binding]; other site 66692011268 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 66692011269 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 66692011270 putative NAD(P) binding site [chemical binding]; other site 66692011271 catalytic Zn binding site [ion binding]; other site 66692011272 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 66692011273 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 66692011274 active site 66692011275 P-loop; other site 66692011276 phosphorylation site [posttranslational modification] 66692011277 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 66692011278 active site 66692011279 phosphorylation site [posttranslational modification] 66692011280 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692011281 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 66692011282 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692011283 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 66692011284 substrate binding site [chemical binding]; other site 66692011285 ATP binding site [chemical binding]; other site 66692011286 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 66692011287 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 66692011288 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 66692011289 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 66692011290 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 66692011291 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692011292 putative active site [active] 66692011293 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 66692011294 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692011295 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692011296 active site turn [active] 66692011297 phosphorylation site [posttranslational modification] 66692011298 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 66692011299 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 66692011300 NAD binding site [chemical binding]; other site 66692011301 sugar binding site [chemical binding]; other site 66692011302 divalent metal binding site [ion binding]; other site 66692011303 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692011304 dimer interface [polypeptide binding]; other site 66692011305 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 66692011306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692011307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011308 dimer interface [polypeptide binding]; other site 66692011309 conserved gate region; other site 66692011310 putative PBP binding loops; other site 66692011311 ABC-ATPase subunit interface; other site 66692011312 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692011313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011314 dimer interface [polypeptide binding]; other site 66692011315 conserved gate region; other site 66692011316 putative PBP binding loops; other site 66692011317 ABC-ATPase subunit interface; other site 66692011318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692011319 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692011320 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 66692011321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692011322 dimerization interface [polypeptide binding]; other site 66692011323 Histidine kinase; Region: His_kinase; pfam06580 66692011324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692011325 ATP binding site [chemical binding]; other site 66692011326 Mg2+ binding site [ion binding]; other site 66692011327 G-X-G motif; other site 66692011328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 66692011329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692011330 active site 66692011331 phosphorylation site [posttranslational modification] 66692011332 intermolecular recognition site; other site 66692011333 dimerization interface [polypeptide binding]; other site 66692011334 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 66692011335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011337 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 66692011338 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 66692011339 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 66692011340 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 66692011341 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 66692011342 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 66692011343 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 66692011344 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 66692011345 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 66692011346 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 66692011347 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 66692011348 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 66692011349 BCCT family transporter; Region: BCCT; pfam02028 66692011350 Predicted membrane protein [Function unknown]; Region: COG4682 66692011351 yiaA/B two helix domain; Region: YiaAB; pfam05360 66692011352 yiaA/B two helix domain; Region: YiaAB; pfam05360 66692011353 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692011354 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692011355 DNA binding site [nucleotide binding] 66692011356 domain linker motif; other site 66692011357 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 66692011358 ligand binding site [chemical binding]; other site 66692011359 dimerization interface [polypeptide binding]; other site 66692011360 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 66692011361 substrate binding site [chemical binding]; other site 66692011362 dimer interface [polypeptide binding]; other site 66692011363 ATP binding site [chemical binding]; other site 66692011364 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 66692011365 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 66692011366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 66692011367 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 66692011368 inhibitor site; inhibition site 66692011369 active site 66692011370 dimer interface [polypeptide binding]; other site 66692011371 catalytic residue [active] 66692011372 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 66692011373 putative active site [active] 66692011374 DAK2 domain; Region: Dak2; cl03685 66692011375 Dak1 domain; Region: Dak1; cl10557 66692011376 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 66692011377 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 66692011378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692011379 putative DNA binding site [nucleotide binding]; other site 66692011380 putative Zn2+ binding site [ion binding]; other site 66692011381 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 66692011382 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 66692011383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692011384 NAD(P) binding site [chemical binding]; other site 66692011385 active site 66692011386 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692011387 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH2; cd08256 66692011388 putative NAD(P) binding site [chemical binding]; other site 66692011389 catalytic Zn binding site [ion binding]; other site 66692011390 structural Zn binding site [ion binding]; other site 66692011391 polyol permease family; Region: 2A0118; TIGR00897 66692011392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692011393 putative substrate translocation pore; other site 66692011394 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 66692011395 DUF35 OB-fold domain; Region: DUF35; pfam01796 66692011396 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 66692011397 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 66692011398 active site 66692011399 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 66692011400 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 66692011401 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 66692011402 acyl-activating enzyme (AAE) consensus motif; other site 66692011403 acyl-activating enzyme (AAE) consensus motif; other site 66692011404 putative AMP binding site [chemical binding]; other site 66692011405 putative active site [active] 66692011406 putative CoA binding site [chemical binding]; other site 66692011407 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 66692011408 trimer interface [polypeptide binding]; other site 66692011409 putative Zn binding site [ion binding]; other site 66692011410 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 66692011411 classical (c) SDRs; Region: SDR_c; cd05233 66692011412 NAD(P) binding site [chemical binding]; other site 66692011413 active site 66692011414 DctM-like transporters; Region: DctM; pfam06808 66692011415 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692011416 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 66692011417 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692011418 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 66692011419 Transcriptional regulator [Transcription]; Region: IclR; COG1414 66692011420 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692011421 putative DNA binding site [nucleotide binding]; other site 66692011422 putative Zn2+ binding site [ion binding]; other site 66692011423 Bacterial transcriptional regulator; Region: IclR; pfam01614 66692011424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692011425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692011426 TPR motif; other site 66692011427 binding surface 66692011428 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692011429 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 66692011430 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 66692011431 dinuclear metal binding motif [ion binding]; other site 66692011432 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 66692011433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 66692011434 hypothetical protein; Provisional; Region: PRK08204 66692011435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692011436 active site 66692011437 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 66692011438 Transcriptional regulators [Transcription]; Region: MarR; COG1846 66692011439 Pirin-related protein [General function prediction only]; Region: COG1741 66692011440 Pirin; Region: Pirin; pfam02678 66692011441 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 66692011442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692011443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692011444 Predicted membrane protein [Function unknown]; Region: COG2311 66692011445 Protein of unknown function (DUF418); Region: DUF418; pfam04235 66692011446 Hsp70 protein; Region: HSP70; pfam00012 66692011447 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 66692011448 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 66692011449 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 66692011450 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692011451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692011452 Walker A/P-loop; other site 66692011453 ATP binding site [chemical binding]; other site 66692011454 Q-loop/lid; other site 66692011455 ABC transporter signature motif; other site 66692011456 Walker B; other site 66692011457 D-loop; other site 66692011458 H-loop/switch region; other site 66692011459 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692011460 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692011461 active site 66692011462 phosphorylation site [posttranslational modification] 66692011463 intermolecular recognition site; other site 66692011464 dimerization interface [polypeptide binding]; other site 66692011465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692011466 DNA binding site [nucleotide binding] 66692011467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692011468 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692011469 dimer interface [polypeptide binding]; other site 66692011470 phosphorylation site [posttranslational modification] 66692011471 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692011472 ATP binding site [chemical binding]; other site 66692011473 Mg2+ binding site [ion binding]; other site 66692011474 G-X-G motif; other site 66692011475 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 66692011476 substrate binding site [chemical binding]; other site 66692011477 dimer interface [polypeptide binding]; other site 66692011478 ATP binding site [chemical binding]; other site 66692011479 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 66692011480 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 66692011481 catalytic triad [active] 66692011482 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 66692011483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692011484 active site 66692011485 phosphorylation site [posttranslational modification] 66692011486 intermolecular recognition site; other site 66692011487 dimerization interface [polypeptide binding]; other site 66692011488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 66692011489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 66692011490 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 66692011491 Histidine kinase; Region: His_kinase; pfam06580 66692011492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692011493 ATP binding site [chemical binding]; other site 66692011494 Mg2+ binding site [ion binding]; other site 66692011495 G-X-G motif; other site 66692011496 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 66692011497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011498 dimer interface [polypeptide binding]; other site 66692011499 conserved gate region; other site 66692011500 putative PBP binding loops; other site 66692011501 ABC-ATPase subunit interface; other site 66692011502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011503 dimer interface [polypeptide binding]; other site 66692011504 conserved gate region; other site 66692011505 putative PBP binding loops; other site 66692011506 ABC-ATPase subunit interface; other site 66692011507 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 66692011508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692011509 Walker A/P-loop; other site 66692011510 ATP binding site [chemical binding]; other site 66692011511 Q-loop/lid; other site 66692011512 ABC transporter signature motif; other site 66692011513 Walker B; other site 66692011514 D-loop; other site 66692011515 H-loop/switch region; other site 66692011516 TOBE domain; Region: TOBE_2; pfam08402 66692011517 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 66692011518 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 66692011519 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 66692011520 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692011521 metal binding site [ion binding]; metal-binding site 66692011522 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 66692011523 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 66692011524 metal binding site [ion binding]; metal-binding site 66692011525 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 66692011526 anion transporter; Region: dass; TIGR00785 66692011527 transmembrane helices; other site 66692011528 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 66692011529 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 66692011530 putative metal binding site [ion binding]; other site 66692011531 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 66692011532 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692011533 Walker A/P-loop; other site 66692011534 ATP binding site [chemical binding]; other site 66692011535 Q-loop/lid; other site 66692011536 ABC transporter signature motif; other site 66692011537 Walker B; other site 66692011538 D-loop; other site 66692011539 H-loop/switch region; other site 66692011540 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692011541 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692011542 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692011543 Walker A/P-loop; other site 66692011544 ATP binding site [chemical binding]; other site 66692011545 Q-loop/lid; other site 66692011546 ABC transporter signature motif; other site 66692011547 Walker B; other site 66692011548 D-loop; other site 66692011549 H-loop/switch region; other site 66692011550 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692011551 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692011552 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692011553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011554 dimer interface [polypeptide binding]; other site 66692011555 conserved gate region; other site 66692011556 putative PBP binding loops; other site 66692011557 ABC-ATPase subunit interface; other site 66692011558 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692011559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011560 dimer interface [polypeptide binding]; other site 66692011561 conserved gate region; other site 66692011562 putative PBP binding loops; other site 66692011563 ABC-ATPase subunit interface; other site 66692011564 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692011565 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 66692011566 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692011567 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692011568 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692011569 dimerization interface [polypeptide binding]; other site 66692011570 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 66692011571 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 66692011572 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 66692011573 nucleotide binding site [chemical binding]; other site 66692011574 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 66692011575 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 66692011576 methionine cluster; other site 66692011577 active site 66692011578 phosphorylation site [posttranslational modification] 66692011579 metal binding site [ion binding]; metal-binding site 66692011580 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 66692011581 active site 66692011582 P-loop; other site 66692011583 phosphorylation site [posttranslational modification] 66692011584 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 66692011585 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 66692011586 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 66692011587 NAD binding site [chemical binding]; other site 66692011588 sugar binding site [chemical binding]; other site 66692011589 divalent metal binding site [ion binding]; other site 66692011590 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692011591 dimer interface [polypeptide binding]; other site 66692011592 CAAX protease self-immunity; Region: Abi; pfam02517 66692011593 Bacterial PH domain; Region: bPH_2; cl01348 66692011594 Predicted membrane protein [Function unknown]; Region: COG3428 66692011595 Bacterial PH domain; Region: bPH_2; pfam03703 66692011596 Bacterial PH domain; Region: bPH_2; pfam03703 66692011597 Bacterial PH domain; Region: bPH_2; pfam03703 66692011598 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692011599 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 66692011600 Predicted transcriptional regulators [Transcription]; Region: COG1733 66692011601 hypothetical protein; Provisional; Region: PRK09739 66692011602 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 66692011603 conserved cys residue [active] 66692011604 Domain of unknown function (DUF3784); Region: DUF3784; pfam12650 66692011605 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 66692011606 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721 66692011607 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 66692011608 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 66692011609 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 66692011610 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 66692011611 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 66692011612 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 66692011613 NADP binding site [chemical binding]; other site 66692011614 active site 66692011615 putative substrate binding site [chemical binding]; other site 66692011616 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 66692011617 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 66692011618 NAD binding site [chemical binding]; other site 66692011619 substrate binding site [chemical binding]; other site 66692011620 homodimer interface [polypeptide binding]; other site 66692011621 active site 66692011622 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 66692011623 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 66692011624 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 66692011625 substrate binding site; other site 66692011626 tetramer interface; other site 66692011627 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 66692011628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 66692011629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 66692011630 active site 66692011631 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 66692011632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 66692011633 active site 66692011634 Protein of unknown function DUF70; Region: DUF70; cl00785 66692011635 Integrase core domain; Region: rve; pfam00665 66692011636 Bacterial sugar transferase; Region: Bac_transf; pfam02397 66692011637 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 66692011638 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 66692011639 active site 66692011640 tetramer interface; other site 66692011641 flagellin; Provisional; Region: PRK12804 66692011642 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 66692011643 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 66692011644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692011645 binding surface 66692011646 TPR motif; other site 66692011647 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692011648 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 66692011649 Spore germination protein; Region: Spore_permease; cl17796 66692011650 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692011651 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 66692011652 putative active site [active] 66692011653 putative FMN binding site [chemical binding]; other site 66692011654 putative substrate binding site [chemical binding]; other site 66692011655 putative catalytic residue [active] 66692011656 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692011657 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692011658 Bacterial PH domain; Region: bPH_4; pfam06713 66692011659 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 66692011660 classical (c) SDRs; Region: SDR_c; cd05233 66692011661 NAD(P) binding site [chemical binding]; other site 66692011662 active site 66692011663 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 66692011664 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 66692011665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692011666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692011667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 66692011668 dimerization interface [polypeptide binding]; other site 66692011669 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692011670 dimerization interface [polypeptide binding]; other site 66692011671 putative DNA binding site [nucleotide binding]; other site 66692011672 putative Zn2+ binding site [ion binding]; other site 66692011673 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 66692011674 Sodium/glutamate symporter; Region: Glt_symporter; cl19414 66692011675 SdpI/YhfL protein family; Region: SdpI; pfam13630 66692011676 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 66692011677 tetramer interface [polypeptide binding]; other site 66692011678 active site 66692011679 Mg2+/Mn2+ binding site [ion binding]; other site 66692011680 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 66692011681 NMT1-like family; Region: NMT1_2; cl17432 66692011682 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 66692011683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 66692011684 substrate binding pocket [chemical binding]; other site 66692011685 membrane-bound complex binding site; other site 66692011686 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692011687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011688 dimer interface [polypeptide binding]; other site 66692011689 conserved gate region; other site 66692011690 putative PBP binding loops; other site 66692011691 ABC-ATPase subunit interface; other site 66692011692 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 66692011693 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692011694 Walker A/P-loop; other site 66692011695 ATP binding site [chemical binding]; other site 66692011696 Q-loop/lid; other site 66692011697 ABC transporter signature motif; other site 66692011698 Walker B; other site 66692011699 D-loop; other site 66692011700 H-loop/switch region; other site 66692011701 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 66692011702 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 66692011703 conserved cys residue [active] 66692011704 purine nucleoside phosphorylase; Provisional; Region: PRK08202 66692011705 Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005 66692011706 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 66692011707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692011708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692011709 Coenzyme A binding pocket [chemical binding]; other site 66692011710 Putative lysophospholipase; Region: Hydrolase_4; cl19140 66692011711 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 66692011712 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 66692011713 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 66692011714 putative NAD(P) binding site [chemical binding]; other site 66692011715 active site 66692011716 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 66692011717 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 66692011718 G1 box; other site 66692011719 putative GEF interaction site [polypeptide binding]; other site 66692011720 GTP/Mg2+ binding site [chemical binding]; other site 66692011721 Switch I region; other site 66692011722 G2 box; other site 66692011723 G3 box; other site 66692011724 Switch II region; other site 66692011725 G4 box; other site 66692011726 G5 box; other site 66692011727 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 66692011728 Elongation Factor G, domain II; Region: EFG_II; pfam14492 66692011729 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 66692011730 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 66692011731 Predicted peptidase [General function prediction only]; Region: COG4099 66692011732 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 66692011733 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 66692011734 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 66692011735 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 66692011736 amidase; Provisional; Region: PRK08310 66692011737 allantoinase; Region: allantoinase; TIGR03178 66692011738 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 66692011739 active site 66692011740 Predicted membrane protein [Function unknown]; Region: COG1288 66692011741 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 66692011742 active site 66692011743 homotetramer interface [polypeptide binding]; other site 66692011744 urate oxidase; Region: urate_oxi; TIGR03383 66692011745 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 66692011746 active site 66692011747 OHCU decarboxylase; Region: UHCUDC; TIGR03164 66692011748 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 66692011749 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 66692011750 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692011751 allantoate amidohydrolase; Reviewed; Region: PRK12893 66692011752 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 66692011753 active site 66692011754 metal binding site [ion binding]; metal-binding site 66692011755 dimer interface [polypeptide binding]; other site 66692011756 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 66692011757 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692011758 catalytic residue [active] 66692011759 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 66692011760 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 66692011761 catalytic loop [active] 66692011762 iron binding site [ion binding]; other site 66692011763 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 66692011764 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 66692011765 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 66692011766 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 66692011767 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 66692011768 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 66692011769 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 66692011770 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 66692011771 Ligand binding site; other site 66692011772 metal-binding site 66692011773 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 66692011774 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 66692011775 XdhC Rossmann domain; Region: XdhC_C; pfam13478 66692011776 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 66692011777 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 66692011778 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692011779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011780 dimer interface [polypeptide binding]; other site 66692011781 conserved gate region; other site 66692011782 putative PBP binding loops; other site 66692011783 ABC-ATPase subunit interface; other site 66692011784 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 66692011785 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692011786 Walker A/P-loop; other site 66692011787 ATP binding site [chemical binding]; other site 66692011788 Q-loop/lid; other site 66692011789 ABC transporter signature motif; other site 66692011790 Walker B; other site 66692011791 D-loop; other site 66692011792 H-loop/switch region; other site 66692011793 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 66692011794 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 66692011795 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 66692011796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011797 dimer interface [polypeptide binding]; other site 66692011798 conserved gate region; other site 66692011799 putative PBP binding loops; other site 66692011800 ABC-ATPase subunit interface; other site 66692011801 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 66692011802 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 66692011803 Walker A/P-loop; other site 66692011804 ATP binding site [chemical binding]; other site 66692011805 Q-loop/lid; other site 66692011806 ABC transporter signature motif; other site 66692011807 Walker B; other site 66692011808 D-loop; other site 66692011809 H-loop/switch region; other site 66692011810 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 66692011811 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692011812 ABC-ATPase subunit interface; other site 66692011813 dimer interface [polypeptide binding]; other site 66692011814 putative PBP binding regions; other site 66692011815 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692011816 ABC-ATPase subunit interface; other site 66692011817 dimer interface [polypeptide binding]; other site 66692011818 putative PBP binding regions; other site 66692011819 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 66692011820 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 66692011821 siderophore binding site; other site 66692011822 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 66692011823 nucleotide binding site/active site [active] 66692011824 HIT family signature motif; other site 66692011825 catalytic residue [active] 66692011826 Transcriptional regulator; Region: Rrf2; cl17282 66692011827 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692011828 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 66692011829 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 66692011830 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 66692011831 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 66692011832 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 66692011833 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 66692011834 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 66692011835 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 66692011836 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 66692011837 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 66692011838 putative active site [active] 66692011839 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 66692011840 DctM-like transporters; Region: DctM; pfam06808 66692011841 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 66692011842 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 66692011843 classical (c) SDRs; Region: SDR_c; cd05233 66692011844 NAD(P) binding site [chemical binding]; other site 66692011845 active site 66692011846 Predicted transcriptional regulator [Transcription]; Region: COG4189 66692011847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 66692011848 putative DNA binding site [nucleotide binding]; other site 66692011849 dimerization interface [polypeptide binding]; other site 66692011850 putative Zn2+ binding site [ion binding]; other site 66692011851 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 66692011852 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692011853 active site turn [active] 66692011854 phosphorylation site [posttranslational modification] 66692011855 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692011856 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 66692011857 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 66692011858 substrate binding [chemical binding]; other site 66692011859 active site 66692011860 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 66692011861 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692011862 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692011863 DNA binding site [nucleotide binding] 66692011864 domain linker motif; other site 66692011865 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 66692011866 dimerization interface [polypeptide binding]; other site 66692011867 ligand binding site [chemical binding]; other site 66692011868 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 66692011869 dimer interface [polypeptide binding]; other site 66692011870 FMN binding site [chemical binding]; other site 66692011871 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692011872 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 66692011873 DNA binding residues [nucleotide binding] 66692011874 dimer interface [polypeptide binding]; other site 66692011875 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692011876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692011877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692011878 Coenzyme A binding pocket [chemical binding]; other site 66692011879 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 66692011880 putative active site [active] 66692011881 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 66692011882 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 66692011883 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 66692011884 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 66692011885 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 66692011886 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 66692011887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011888 dimer interface [polypeptide binding]; other site 66692011889 conserved gate region; other site 66692011890 putative PBP binding loops; other site 66692011891 ABC-ATPase subunit interface; other site 66692011892 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692011893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692011894 dimer interface [polypeptide binding]; other site 66692011895 conserved gate region; other site 66692011896 putative PBP binding loops; other site 66692011897 ABC-ATPase subunit interface; other site 66692011898 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 66692011899 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692011900 DNA binding residues [nucleotide binding] 66692011901 putative dimer interface [polypeptide binding]; other site 66692011902 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 66692011903 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692011904 DNA binding residues [nucleotide binding] 66692011905 putative dimer interface [polypeptide binding]; other site 66692011906 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 66692011907 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 66692011908 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692011909 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692011910 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 66692011911 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 66692011912 homodimer interface [polypeptide binding]; other site 66692011913 active site 66692011914 FMN binding site [chemical binding]; other site 66692011915 substrate binding site [chemical binding]; other site 66692011916 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 66692011917 phenylhydantoinase; Validated; Region: PRK08323 66692011918 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 66692011919 tetramer interface [polypeptide binding]; other site 66692011920 active site 66692011921 allantoate amidohydrolase; Reviewed; Region: PRK12890 66692011922 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 66692011923 active site 66692011924 metal binding site [ion binding]; metal-binding site 66692011925 dimer interface [polypeptide binding]; other site 66692011926 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 66692011927 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 66692011928 inhibitor-cofactor binding pocket; inhibition site 66692011929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692011930 catalytic residue [active] 66692011931 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 66692011932 putative active site pocket [active] 66692011933 dimerization interface [polypeptide binding]; other site 66692011934 putative catalytic residue [active] 66692011935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 66692011936 NAD(P) binding site [chemical binding]; other site 66692011937 active site 66692011938 Predicted transcriptional regulator [Transcription]; Region: COG1959 66692011939 Rrf2 family protein; Region: rrf2_super; TIGR00738 66692011940 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 66692011941 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 66692011942 active site turn [active] 66692011943 phosphorylation site [posttranslational modification] 66692011944 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 66692011945 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 66692011946 HPr interaction site; other site 66692011947 glycerol kinase (GK) interaction site [polypeptide binding]; other site 66692011948 active site 66692011949 phosphorylation site [posttranslational modification] 66692011950 transcriptional antiterminator BglG; Provisional; Region: PRK09772 66692011951 CAT RNA binding domain; Region: CAT_RBD; smart01061 66692011952 PRD domain; Region: PRD; pfam00874 66692011953 PRD domain; Region: PRD; pfam00874 66692011954 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 66692011955 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 66692011956 Protein of unknown function, DUF600; Region: DUF600; cl04640 66692011957 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 66692011958 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 66692011959 Immunity protein 42; Region: Imm42; pfam15601 66692011960 LXG domain of WXG superfamily; Region: LXG; pfam04740 66692011961 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 66692011962 carboxyl-terminal processing protease; Provisional; Region: PLN00049 66692011963 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 66692011964 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692011965 Tetratricopeptide repeat; Region: TPR_12; pfam13424 66692011966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692011967 binding surface 66692011968 TPR motif; other site 66692011969 GAF domain; Region: GAF; pfam01590 66692011970 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692011971 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 66692011972 NAD(P) binding site [chemical binding]; other site 66692011973 catalytic residues [active] 66692011974 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 66692011975 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 66692011976 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase; Region: NAD_binding_11; pfam14833 66692011977 Protein of unknown function (DUF3100); Region: DUF3100; pfam11299 66692011978 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 66692011979 PHP domain; Region: PHP; pfam02811 66692011980 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 66692011981 AAA domain; Region: AAA_31; pfam13614 66692011982 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 66692011983 Chain length determinant protein; Region: Wzz; pfam02706 66692011984 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 66692011985 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 66692011986 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 66692011987 binding surface 66692011988 Tetratricopeptide repeat; Region: TPR_16; pfam13432 66692011989 TPR motif; other site 66692011990 Tetratrico peptide repeat; Region: TPR_5; pfam12688 66692011991 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 66692011992 nucleoside/Zn binding site; other site 66692011993 dimer interface [polypeptide binding]; other site 66692011994 catalytic motif [active] 66692011995 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 66692011996 nucleotide binding site/active site [active] 66692011997 HIT family signature motif; other site 66692011998 catalytic residue [active] 66692011999 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 66692012000 UDP-glucose 4-epimerase; Region: PLN02240 66692012001 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 66692012002 NAD binding site [chemical binding]; other site 66692012003 homodimer interface [polypeptide binding]; other site 66692012004 active site 66692012005 substrate binding site [chemical binding]; other site 66692012006 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 66692012007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692012008 Coenzyme A binding pocket [chemical binding]; other site 66692012009 DNA polymerase IV; Reviewed; Region: PRK03103 66692012010 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 66692012011 active site 66692012012 DNA binding site [nucleotide binding] 66692012013 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692012014 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 66692012015 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692012016 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692012017 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 66692012018 NlpC/P60 family; Region: NLPC_P60; pfam00877 66692012019 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 66692012020 DinB family; Region: DinB; cl17821 66692012021 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 66692012022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692012023 Predicted membrane protein [Function unknown]; Region: COG1511 66692012024 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 66692012025 Spindle pole body component BBP1, C-terminal; Region: BBP1_C; pfam15272 66692012026 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 66692012027 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 66692012028 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 66692012029 Putative esterase; Region: Esterase; pfam00756 66692012030 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 66692012031 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl19906 66692012032 Spore germination protein; Region: Spore_permease; cl17796 66692012033 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 66692012034 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 66692012035 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 66692012036 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 66692012037 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 66692012038 flagellar basal body rod protein FlgB; Provisional; Region: flgB; cl19173 66692012039 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 66692012040 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 66692012041 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 66692012042 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 66692012043 rod shape-determining protein Mbl; Provisional; Region: PRK13928 66692012044 MreB and similar proteins; Region: MreB_like; cd10225 66692012045 nucleotide binding site [chemical binding]; other site 66692012046 Mg binding site [ion binding]; other site 66692012047 putative protofilament interaction site [polypeptide binding]; other site 66692012048 RodZ interaction site [polypeptide binding]; other site 66692012049 Stage III sporulation protein D; Region: SpoIIID; cl17560 66692012050 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 66692012051 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 66692012052 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 66692012053 Peptidase family M23; Region: Peptidase_M23; pfam01551 66692012054 stage II sporulation protein D; Region: spore_II_D; TIGR02870 66692012055 Stage II sporulation protein; Region: SpoIID; pfam08486 66692012056 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 66692012057 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 66692012058 hinge; other site 66692012059 active site 66692012060 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 66692012061 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 66692012062 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 66692012063 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 66692012064 gamma subunit interface [polypeptide binding]; other site 66692012065 epsilon subunit interface [polypeptide binding]; other site 66692012066 LBP interface [polypeptide binding]; other site 66692012067 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 66692012068 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 66692012069 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 66692012070 alpha subunit interaction interface [polypeptide binding]; other site 66692012071 Walker A motif; other site 66692012072 ATP binding site [chemical binding]; other site 66692012073 Walker B motif; other site 66692012074 inhibitor binding site; inhibition site 66692012075 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 66692012076 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 66692012077 core domain interface [polypeptide binding]; other site 66692012078 delta subunit interface [polypeptide binding]; other site 66692012079 epsilon subunit interface [polypeptide binding]; other site 66692012080 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 66692012081 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 66692012082 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 66692012083 beta subunit interaction interface [polypeptide binding]; other site 66692012084 Walker A motif; other site 66692012085 ATP binding site [chemical binding]; other site 66692012086 Walker B motif; other site 66692012087 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 66692012088 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 66692012089 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 66692012090 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 66692012091 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 66692012092 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 66692012093 ATP synthase I chain; Region: ATP_synt_I; pfam03899 66692012094 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 66692012095 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 66692012096 Subtilase family; Region: Peptidase_S8; pfam00082 66692012097 catalytic triad [active] 66692012098 putative active site [active] 66692012099 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 66692012100 PA/protease domain interface [polypeptide binding]; other site 66692012101 putative integrin binding motif; other site 66692012102 IG-like fold at C-terminal of FixG, putative oxidoreductase; Region: FixG_C; pfam11614 66692012103 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 66692012104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692012105 Coenzyme A binding pocket [chemical binding]; other site 66692012106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 66692012107 active site 66692012108 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 66692012109 dimer interface [polypeptide binding]; other site 66692012110 active site 66692012111 glycine-pyridoxal phosphate binding site [chemical binding]; other site 66692012112 folate binding site [chemical binding]; other site 66692012113 hypothetical protein; Provisional; Region: PRK13690 66692012114 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 66692012115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692012116 dimerization interface [polypeptide binding]; other site 66692012117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692012118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 66692012119 dimer interface [polypeptide binding]; other site 66692012120 putative CheW interface [polypeptide binding]; other site 66692012121 Low molecular weight phosphatase family; Region: LMWPc; cd00115 66692012122 active site 66692012123 Predicted membrane protein [Function unknown]; Region: COG1971 66692012124 Domain of unknown function DUF; Region: DUF204; pfam02659 66692012125 Domain of unknown function DUF; Region: DUF204; pfam02659 66692012126 Regulator of ribonuclease activity B; Region: RraB; pfam06877 66692012127 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 66692012128 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 66692012129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692012130 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 66692012131 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 66692012132 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 66692012133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692012134 S-adenosylmethionine binding site [chemical binding]; other site 66692012135 peptide chain release factor 1; Validated; Region: prfA; PRK00591 66692012136 This domain is found in peptide chain release factors; Region: PCRF; smart00937 66692012137 RF-1 domain; Region: RF-1; pfam00472 66692012138 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 66692012139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 66692012140 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 66692012141 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 66692012142 thymidine kinase; Provisional; Region: PRK04296 66692012143 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 66692012144 transcription termination factor Rho; Provisional; Region: rho; PRK09376 66692012145 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 66692012146 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 66692012147 RNA binding site [nucleotide binding]; other site 66692012148 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 66692012149 multimer interface [polypeptide binding]; other site 66692012150 Walker A motif; other site 66692012151 ATP binding site [chemical binding]; other site 66692012152 Walker B motif; other site 66692012153 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 66692012154 putative active site [active] 66692012155 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 66692012156 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 66692012157 hinge; other site 66692012158 active site 66692012159 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 66692012160 active site 66692012161 intersubunit interactions; other site 66692012162 catalytic residue [active] 66692012163 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 66692012164 intersubunit interface [polypeptide binding]; other site 66692012165 active site 66692012166 zinc binding site [ion binding]; other site 66692012167 Na+ binding site [ion binding]; other site 66692012168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692012169 active site 66692012170 phosphorylation site [posttranslational modification] 66692012171 intermolecular recognition site; other site 66692012172 dimerization interface [polypeptide binding]; other site 66692012173 Protein of unknown function (DUF2529); Region: DUF2529; pfam10740 66692012174 CTP synthetase; Validated; Region: pyrG; PRK05380 66692012175 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 66692012176 Catalytic site [active] 66692012177 active site 66692012178 UTP binding site [chemical binding]; other site 66692012179 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 66692012180 active site 66692012181 putative oxyanion hole; other site 66692012182 catalytic triad [active] 66692012183 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 66692012184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692012185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 66692012186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 66692012187 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 66692012188 FAD binding site [chemical binding]; other site 66692012189 homotetramer interface [polypeptide binding]; other site 66692012190 substrate binding pocket [chemical binding]; other site 66692012191 catalytic base [active] 66692012192 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 66692012193 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 66692012194 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 66692012195 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 66692012196 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 66692012197 dimer interface [polypeptide binding]; other site 66692012198 active site 66692012199 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 66692012200 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692012201 Cysteine-rich domain; Region: CCG; pfam02754 66692012202 Cysteine-rich domain; Region: CCG; pfam02754 66692012203 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 66692012204 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 66692012205 putative active site [active] 66692012206 catalytic site [active] 66692012207 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 66692012208 putative active site [active] 66692012209 catalytic site [active] 66692012210 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 66692012211 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 66692012212 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 66692012213 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 66692012214 active site 66692012215 HIGH motif; other site 66692012216 KMSK motif region; other site 66692012217 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 66692012218 tRNA binding surface [nucleotide binding]; other site 66692012219 anticodon binding site; other site 66692012220 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 66692012221 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 66692012222 putative active site [active] 66692012223 Mn binding site [ion binding]; other site 66692012224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692012225 S-adenosylmethionine binding site [chemical binding]; other site 66692012226 Transglycosylase; Region: Transgly; pfam00912 66692012227 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 66692012228 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 66692012229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692012230 Coenzyme A binding pocket [chemical binding]; other site 66692012231 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692012232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692012233 Coenzyme A binding pocket [chemical binding]; other site 66692012234 oligoendopeptidase F; Region: pepF; TIGR00181 66692012235 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 66692012236 active site 66692012237 Zn binding site [ion binding]; other site 66692012238 YwhD family; Region: YwhD; pfam08741 66692012239 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 66692012240 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 66692012241 active site 66692012242 catalytic site [active] 66692012243 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 66692012244 active site 1 [active] 66692012245 dimer interface [polypeptide binding]; other site 66692012246 hexamer interface [polypeptide binding]; other site 66692012247 active site 2 [active] 66692012248 Uncharacterized conserved protein [Function unknown]; Region: COG3465 66692012249 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 66692012250 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 66692012251 Zn2+ binding site [ion binding]; other site 66692012252 Mg2+ binding site [ion binding]; other site 66692012253 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 66692012254 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 66692012255 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 66692012256 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 66692012257 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 66692012258 substrate binding site [chemical binding]; other site 66692012259 oxyanion hole (OAH) forming residues; other site 66692012260 trimer interface [polypeptide binding]; other site 66692012261 putative heme peroxidase; Provisional; Region: PRK12276 66692012262 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 66692012263 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 66692012264 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 66692012265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692012266 Walker A/P-loop; other site 66692012267 ATP binding site [chemical binding]; other site 66692012268 Q-loop/lid; other site 66692012269 ABC transporter signature motif; other site 66692012270 Walker B; other site 66692012271 D-loop; other site 66692012272 H-loop/switch region; other site 66692012273 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 66692012274 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 66692012275 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692012276 Walker A/P-loop; other site 66692012277 ATP binding site [chemical binding]; other site 66692012278 Q-loop/lid; other site 66692012279 ABC transporter signature motif; other site 66692012280 Walker B; other site 66692012281 D-loop; other site 66692012282 H-loop/switch region; other site 66692012283 Predicted transcriptional regulators [Transcription]; Region: COG1725 66692012284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692012285 DNA-binding site [nucleotide binding]; DNA binding site 66692012286 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 66692012287 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 66692012288 Protein of unknown function (DUF423); Region: DUF423; pfam04241 66692012289 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692012290 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 66692012291 Na binding site [ion binding]; other site 66692012292 hypothetical protein; Provisional; Region: PRK07740 66692012293 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 66692012294 active site 66692012295 catalytic site [active] 66692012296 substrate binding site [chemical binding]; other site 66692012297 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 66692012298 metal binding triad; other site 66692012299 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 66692012300 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 66692012301 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 66692012302 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 66692012303 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 66692012304 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 66692012305 ligand binding site [chemical binding]; other site 66692012306 active site 66692012307 UGI interface [polypeptide binding]; other site 66692012308 catalytic site [active] 66692012309 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 66692012310 Nucleoside recognition; Region: Gate; pfam07670 66692012311 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 66692012312 dimer interface [polypeptide binding]; other site 66692012313 substrate binding site [chemical binding]; other site 66692012314 ATP binding site [chemical binding]; other site 66692012315 Aromatic amino acid lyase; Region: Lyase_aromatic; pfam00221 66692012316 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 66692012317 active sites [active] 66692012318 tetramer interface [polypeptide binding]; other site 66692012319 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 66692012320 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 66692012321 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 66692012322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692012323 DNA-binding site [nucleotide binding]; DNA binding site 66692012324 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 66692012325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692012326 homodimer interface [polypeptide binding]; other site 66692012327 catalytic residue [active] 66692012328 B3/4 domain; Region: B3_4; cl19243 66692012329 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 66692012330 homodimer interface [polypeptide binding]; other site 66692012331 substrate-cofactor binding pocket; other site 66692012332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 66692012333 catalytic residue [active] 66692012334 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 66692012335 putative di-iron ligands [ion binding]; other site 66692012336 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 66692012337 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 66692012338 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 66692012339 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 66692012340 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692012341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692012342 Coenzyme A binding pocket [chemical binding]; other site 66692012343 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 66692012344 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 66692012345 ATP binding site [chemical binding]; other site 66692012346 Mg++ binding site [ion binding]; other site 66692012347 motif III; other site 66692012348 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 66692012349 nucleotide binding region [chemical binding]; other site 66692012350 ATP-binding site [chemical binding]; other site 66692012351 mRNA cap methylation, RNMT-activating mini protein; Region: RAM; pfam15320 66692012352 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 66692012353 catalytic residues [active] 66692012354 putative disulfide oxidoreductase; Provisional; Region: PRK03113 66692012355 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 66692012356 FAD dependent oxidoreductase; Region: DAO; pfam01266 66692012357 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 66692012358 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 66692012359 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 66692012360 [2Fe-2S] cluster binding site [ion binding]; other site 66692012361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 66692012362 Flotillin or reggie family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_flotillin; cd03399 66692012363 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 66692012364 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 66692012365 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 66692012366 active site 66692012367 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 66692012368 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 66692012369 dimer interface [polypeptide binding]; other site 66692012370 active site 66692012371 DNA topoisomerase III; Provisional; Region: PRK07726 66692012372 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 66692012373 active site 66692012374 putative interdomain interaction site [polypeptide binding]; other site 66692012375 putative metal-binding site [ion binding]; other site 66692012376 putative nucleotide binding site [chemical binding]; other site 66692012377 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 66692012378 DNA binding groove [nucleotide binding] 66692012379 domain I; other site 66692012380 phosphate binding site [ion binding]; other site 66692012381 domain II; other site 66692012382 domain III; other site 66692012383 nucleotide binding site [chemical binding]; other site 66692012384 catalytic site [active] 66692012385 domain IV; other site 66692012386 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 66692012387 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 66692012388 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 66692012389 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 66692012390 putative RNA binding site [nucleotide binding]; other site 66692012391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692012392 S-adenosylmethionine binding site [chemical binding]; other site 66692012393 integral membrane protein; Region: integ_memb_HG; TIGR03954 66692012394 Heat induced stress protein YflT; Region: YflT; pfam11181 66692012395 hypothetical protein; Provisional; Region: PRK03057 66692012396 UPF0302 domain; Region: UPF0302; pfam08864 66692012397 IDEAL domain; Region: IDEAL; pfam08858 66692012398 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692012399 ABC-ATPase subunit interface; other site 66692012400 dimer interface [polypeptide binding]; other site 66692012401 putative PBP binding regions; other site 66692012402 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 66692012403 ABC-ATPase subunit interface; other site 66692012404 dimer interface [polypeptide binding]; other site 66692012405 putative PBP binding regions; other site 66692012406 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 66692012407 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 66692012408 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 66692012409 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 66692012410 intersubunit interface [polypeptide binding]; other site 66692012411 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 66692012412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 66692012413 active site 66692012414 motif I; other site 66692012415 motif II; other site 66692012416 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 66692012417 hypothetical protein; Provisional; Region: PRK08201 66692012418 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 66692012419 metal binding site [ion binding]; metal-binding site 66692012420 putative dimer interface [polypeptide binding]; other site 66692012421 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 66692012422 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 66692012423 Sterol carrier protein domain; Region: SCP2_2; pfam13530 66692012424 Cache domain; Region: Cache_1; pfam02743 66692012425 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692012426 dimerization interface [polypeptide binding]; other site 66692012427 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692012428 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 66692012429 dimer interface [polypeptide binding]; other site 66692012430 putative CheW interface [polypeptide binding]; other site 66692012431 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 66692012432 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 66692012433 active site 66692012434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692012435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 66692012436 putative substrate translocation pore; other site 66692012437 DinB superfamily; Region: DinB_2; pfam12867 66692012438 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 66692012439 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 66692012440 tetramer interface [polypeptide binding]; other site 66692012441 heme binding pocket [chemical binding]; other site 66692012442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 66692012443 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 66692012444 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 66692012445 Walker A/P-loop; other site 66692012446 ATP binding site [chemical binding]; other site 66692012447 Q-loop/lid; other site 66692012448 ABC transporter signature motif; other site 66692012449 Walker B; other site 66692012450 D-loop; other site 66692012451 H-loop/switch region; other site 66692012452 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 66692012453 FAD binding domain; Region: FAD_binding_4; pfam01565 66692012454 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 66692012455 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 66692012456 Predicted membrane protein [Function unknown]; Region: COG2323 66692012457 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 66692012458 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 66692012459 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 66692012460 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692012461 DNA binding residues [nucleotide binding] 66692012462 dimer interface [polypeptide binding]; other site 66692012463 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 66692012464 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 66692012465 GrpB protein; Region: GrpB; pfam04229 66692012466 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 66692012467 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 66692012468 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 66692012469 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 66692012470 active site 66692012471 dimer interface [polypeptide binding]; other site 66692012472 motif 1; other site 66692012473 motif 2; other site 66692012474 motif 3; other site 66692012475 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 66692012476 anticodon binding site; other site 66692012477 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 66692012478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 66692012479 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 66692012480 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 66692012481 catalytic motif [active] 66692012482 Zn binding site [ion binding]; other site 66692012483 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 66692012484 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 66692012485 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692012486 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692012487 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 66692012488 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692012489 dimer interface [polypeptide binding]; other site 66692012490 phosphorylation site [posttranslational modification] 66692012491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692012492 ATP binding site [chemical binding]; other site 66692012493 Mg2+ binding site [ion binding]; other site 66692012494 G-X-G motif; other site 66692012495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692012496 active site 66692012497 phosphorylation site [posttranslational modification] 66692012498 intermolecular recognition site; other site 66692012499 dimerization interface [polypeptide binding]; other site 66692012500 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 66692012501 Histidine kinase; Region: His_kinase; pfam06580 66692012502 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692012503 ATP binding site [chemical binding]; other site 66692012504 Mg2+ binding site [ion binding]; other site 66692012505 G-X-G motif; other site 66692012506 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 66692012507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 66692012508 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 66692012509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692012510 Walker A/P-loop; other site 66692012511 ATP binding site [chemical binding]; other site 66692012512 Q-loop/lid; other site 66692012513 ABC transporter signature motif; other site 66692012514 Walker B; other site 66692012515 D-loop; other site 66692012516 H-loop/switch region; other site 66692012517 anion transporter; Region: dass; TIGR00785 66692012518 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 66692012519 transmembrane helices; other site 66692012520 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 66692012521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692012522 active site 66692012523 phosphorylation site [posttranslational modification] 66692012524 intermolecular recognition site; other site 66692012525 dimerization interface [polypeptide binding]; other site 66692012526 sensory histidine kinase DcuS; Provisional; Region: PRK11086 66692012527 Sensory domain of two-component sensor kinase; Region: Cache_3; pfam14827 66692012528 PAS domain; Region: PAS_8; pfam13188 66692012529 Sensor_kinase_SpoOB-type, alpha-helical domain; Region: SPOB_a; pfam14689 66692012530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692012531 ATP binding site [chemical binding]; other site 66692012532 Mg2+ binding site [ion binding]; other site 66692012533 G-X-G motif; other site 66692012534 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 66692012535 nudix motif; other site 66692012536 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cd00455 66692012537 active site 66692012538 CHY zinc finger; Region: zf-CHY; cl19861 66692012539 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 66692012540 Predicted integral membrane protein [Function unknown]; Region: COG5658 66692012541 SdpI/YhfL protein family; Region: SdpI; pfam13630 66692012542 H+ Antiporter protein; Region: 2A0121; TIGR00900 66692012543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692012544 putative substrate translocation pore; other site 66692012545 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 66692012546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692012547 Methyltransferase domain; Region: Methyltransf_31; pfam13847 66692012548 S-adenosylmethionine binding site [chemical binding]; other site 66692012549 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 66692012550 Na2 binding site [ion binding]; other site 66692012551 putative substrate binding site 1 [chemical binding]; other site 66692012552 Na binding site 1 [ion binding]; other site 66692012553 putative substrate binding site 2 [chemical binding]; other site 66692012554 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 66692012555 aromatic arch; other site 66692012556 DCoH dimer interaction site [polypeptide binding]; other site 66692012557 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 66692012558 DCoH tetramer interaction site [polypeptide binding]; other site 66692012559 substrate binding site [chemical binding]; other site 66692012560 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 66692012561 YtkA-like; Region: YtkA; pfam13115 66692012562 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 66692012563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692012564 dimerization interface [polypeptide binding]; other site 66692012565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692012566 dimer interface [polypeptide binding]; other site 66692012567 phosphorylation site [posttranslational modification] 66692012568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692012569 ATP binding site [chemical binding]; other site 66692012570 Mg2+ binding site [ion binding]; other site 66692012571 G-X-G motif; other site 66692012572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692012573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692012574 active site 66692012575 phosphorylation site [posttranslational modification] 66692012576 intermolecular recognition site; other site 66692012577 dimerization interface [polypeptide binding]; other site 66692012578 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692012579 DNA binding site [nucleotide binding] 66692012580 Uncharacterized conserved protein [Function unknown]; Region: COG3391 66692012581 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 66692012582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 66692012583 putative substrate translocation pore; other site 66692012584 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 66692012585 Predicted transcriptional regulators [Transcription]; Region: COG1695 66692012586 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 66692012587 putative active site [active] 66692012588 EDD domain protein, DegV family; Region: DegV; TIGR00762 66692012589 MutS domain III; Region: MutS_III; pfam05192 66692012590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 66692012591 Walker A/P-loop; other site 66692012592 ATP binding site [chemical binding]; other site 66692012593 Q-loop/lid; other site 66692012594 ABC transporter signature motif; other site 66692012595 Walker B; other site 66692012596 D-loop; other site 66692012597 H-loop/switch region; other site 66692012598 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 66692012599 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 66692012600 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 66692012601 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 66692012602 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 66692012603 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 66692012604 Zn binding site [ion binding]; other site 66692012605 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 66692012606 Zn binding site [ion binding]; other site 66692012607 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 66692012608 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 66692012609 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 66692012610 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 66692012611 Transcriptional regulators [Transcription]; Region: PurR; COG1609 66692012612 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 66692012613 DNA binding site [nucleotide binding] 66692012614 domain linker motif; other site 66692012615 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 66692012616 putative dimerization interface [polypeptide binding]; other site 66692012617 putative ligand binding site [chemical binding]; other site 66692012618 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 66692012619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692012620 dimer interface [polypeptide binding]; other site 66692012621 conserved gate region; other site 66692012622 putative PBP binding loops; other site 66692012623 ABC-ATPase subunit interface; other site 66692012624 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 66692012625 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 66692012626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692012627 dimer interface [polypeptide binding]; other site 66692012628 conserved gate region; other site 66692012629 putative PBP binding loops; other site 66692012630 ABC-ATPase subunit interface; other site 66692012631 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 66692012632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 66692012633 maltodextrin glucosidase; Provisional; Region: PRK10785 66692012634 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 66692012635 homodimer interface [polypeptide binding]; other site 66692012636 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 66692012637 active site 66692012638 homodimer interface [polypeptide binding]; other site 66692012639 catalytic site [active] 66692012640 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 66692012641 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 66692012642 active site 66692012643 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 66692012644 Na binding site [ion binding]; other site 66692012645 putative substrate binding site [chemical binding]; other site 66692012646 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 66692012647 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 66692012648 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 66692012649 Predicted dehydrogenase [General function prediction only]; Region: COG0579 66692012650 hydroxyglutarate oxidase; Provisional; Region: PRK11728 66692012651 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 66692012652 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 66692012653 Cysteine-rich domain; Region: CCG; pfam02754 66692012654 Cysteine-rich domain; Region: CCG; pfam02754 66692012655 FAD binding domain; Region: FAD_binding_4; pfam01565 66692012656 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 66692012657 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 66692012658 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692012659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692012660 DNA-binding site [nucleotide binding]; DNA binding site 66692012661 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 66692012662 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692012663 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692012664 DNA-binding site [nucleotide binding]; DNA binding site 66692012665 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 66692012666 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 66692012667 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 66692012668 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 66692012669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 66692012670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 66692012671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 66692012672 dimerization interface [polypeptide binding]; other site 66692012673 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 66692012674 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 66692012675 dimer interface [polypeptide binding]; other site 66692012676 active site 66692012677 citrylCoA binding site [chemical binding]; other site 66692012678 oxalacetate/citrate binding site [chemical binding]; other site 66692012679 coenzyme A binding site [chemical binding]; other site 66692012680 catalytic triad [active] 66692012681 DctM-like transporters; Region: DctM; pfam06808 66692012682 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692012683 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692012684 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692012685 Transcriptional regulators [Transcription]; Region: FadR; COG2186 66692012686 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692012687 DNA-binding site [nucleotide binding]; DNA binding site 66692012688 FCD domain; Region: FCD; pfam07729 66692012689 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 66692012690 Cache domain; Region: Cache_1; pfam02743 66692012691 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692012692 dimerization interface [polypeptide binding]; other site 66692012693 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 66692012694 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 66692012695 dimer interface [polypeptide binding]; other site 66692012696 putative CheW interface [polypeptide binding]; other site 66692012697 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 66692012698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 66692012699 Coenzyme A binding pocket [chemical binding]; other site 66692012700 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 66692012701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 66692012702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 66692012703 DNA binding residues [nucleotide binding] 66692012704 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 66692012705 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 66692012706 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 66692012707 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 66692012708 CGNR zinc finger; Region: zf-CGNR; pfam11706 66692012709 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 66692012710 Carbon starvation protein CstA; Region: CstA; pfam02554 66692012711 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 66692012712 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 66692012713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692012714 active site 66692012715 phosphorylation site [posttranslational modification] 66692012716 intermolecular recognition site; other site 66692012717 dimerization interface [polypeptide binding]; other site 66692012718 LytTr DNA-binding domain; Region: LytTR; pfam04397 66692012719 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 66692012720 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 66692012721 GAF domain; Region: GAF; cl17456 66692012722 Histidine kinase; Region: His_kinase; pfam06580 66692012723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692012724 ATP binding site [chemical binding]; other site 66692012725 Mg2+ binding site [ion binding]; other site 66692012726 G-X-G motif; other site 66692012727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 66692012728 Bacterial regulatory proteins, tetR family; Region: TetR_N; cl19382 66692012729 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 66692012730 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 66692012731 MMPL family; Region: MMPL; cl14618 66692012732 MMPL family; Region: MMPL; cl14618 66692012733 Predicted membrane protein [Function unknown]; Region: COG1511 66692012734 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 66692012735 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692012736 Walker A/P-loop; other site 66692012737 ATP binding site [chemical binding]; other site 66692012738 Q-loop/lid; other site 66692012739 ABC transporter signature motif; other site 66692012740 Walker B; other site 66692012741 D-loop; other site 66692012742 H-loop/switch region; other site 66692012743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692012744 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 66692012745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 66692012746 Walker A/P-loop; other site 66692012747 ATP binding site [chemical binding]; other site 66692012748 Q-loop/lid; other site 66692012749 ABC transporter signature motif; other site 66692012750 Walker B; other site 66692012751 D-loop; other site 66692012752 H-loop/switch region; other site 66692012753 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 66692012754 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 66692012755 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 66692012756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692012757 dimer interface [polypeptide binding]; other site 66692012758 conserved gate region; other site 66692012759 putative PBP binding loops; other site 66692012760 ABC-ATPase subunit interface; other site 66692012761 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 66692012762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 66692012763 dimer interface [polypeptide binding]; other site 66692012764 conserved gate region; other site 66692012765 putative PBP binding loops; other site 66692012766 ABC-ATPase subunit interface; other site 66692012767 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 66692012768 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 66692012769 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 66692012770 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 66692012771 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 66692012772 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 66692012773 Walker A/P-loop; other site 66692012774 ATP binding site [chemical binding]; other site 66692012775 Q-loop/lid; other site 66692012776 ABC transporter signature motif; other site 66692012777 Walker B; other site 66692012778 D-loop; other site 66692012779 H-loop/switch region; other site 66692012780 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 66692012781 active site 66692012782 active pocket/dimerization site; other site 66692012783 phosphorylation site [posttranslational modification] 66692012784 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 66692012785 active site 66692012786 phosphorylation site [posttranslational modification] 66692012787 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 66692012788 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 66692012789 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 66692012790 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 66692012791 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 66692012792 dimer interface [polypeptide binding]; other site 66692012793 active site 66692012794 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 66692012795 dimer interface [polypeptide binding]; other site 66692012796 active site 66692012797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 66692012798 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 66692012799 Walker A motif; other site 66692012800 ATP binding site [chemical binding]; other site 66692012801 Walker B motif; other site 66692012802 arginine finger; other site 66692012803 Transcriptional antiterminator [Transcription]; Region: COG3933 66692012804 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 66692012805 active pocket/dimerization site; other site 66692012806 active site 66692012807 phosphorylation site [posttranslational modification] 66692012808 PRD domain; Region: PRD; pfam00874 66692012809 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 66692012810 intersubunit interface [polypeptide binding]; other site 66692012811 active site 66692012812 Zn2+ binding site [ion binding]; other site 66692012813 DctM-like transporters; Region: DctM; pfam06808 66692012814 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 66692012815 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 66692012816 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 66692012817 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 66692012818 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 66692012819 NAD(P) binding site [chemical binding]; other site 66692012820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 66692012821 DNA-binding site [nucleotide binding]; DNA binding site 66692012822 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 66692012823 FCD domain; Region: FCD; pfam07729 66692012824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 66692012825 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 66692012826 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 66692012827 active site 66692012828 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 66692012829 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 66692012830 DNA binding residues [nucleotide binding] 66692012831 dimer interface [polypeptide binding]; other site 66692012832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 66692012833 S-adenosylmethionine binding site [chemical binding]; other site 66692012834 TatD related DNase; Region: TatD_DNase; pfam01026 66692012835 active site 66692012836 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 66692012837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 66692012838 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 66692012839 serine endoprotease; Provisional; Region: PRK10898 66692012840 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 66692012841 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 66692012842 protein binding site [polypeptide binding]; other site 66692012843 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 66692012844 YycH protein; Region: YycI; pfam09648 66692012845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 66692012846 YycH protein; Region: YycH; pfam07435 66692012847 gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513 66692012848 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 66692012849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 66692012850 dimerization interface [polypeptide binding]; other site 66692012851 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 66692012852 putative active site [active] 66692012853 heme pocket [chemical binding]; other site 66692012854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 66692012855 dimer interface [polypeptide binding]; other site 66692012856 phosphorylation site [posttranslational modification] 66692012857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 66692012858 ATP binding site [chemical binding]; other site 66692012859 Mg2+ binding site [ion binding]; other site 66692012860 G-X-G motif; other site 66692012861 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 66692012862 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 66692012863 active site 66692012864 phosphorylation site [posttranslational modification] 66692012865 intermolecular recognition site; other site 66692012866 dimerization interface [polypeptide binding]; other site 66692012867 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 66692012868 DNA binding site [nucleotide binding] 66692012869 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 66692012870 GDP-binding site [chemical binding]; other site 66692012871 ACT binding site; other site 66692012872 IMP binding site; other site 66692012873 replicative DNA helicase; Provisional; Region: PRK05748 66692012874 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 66692012875 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 66692012876 Walker A motif; other site 66692012877 ATP binding site [chemical binding]; other site 66692012878 Walker B motif; other site 66692012879 DNA binding loops [nucleotide binding] 66692012880 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 66692012881 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 66692012882 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 66692012883 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 66692012884 Conserved membrane protein YqhR; Region: YqhR; pfam11085 66692012885 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 66692012886 DHH family; Region: DHH; pfam01368 66692012887 DHHA1 domain; Region: DHHA1; pfam02272 66692012888 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 66692012889 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 66692012890 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 66692012891 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 66692012892 dimer interface [polypeptide binding]; other site 66692012893 ssDNA binding site [nucleotide binding]; other site 66692012894 tetramer (dimer of dimers) interface [polypeptide binding]; other site 66692012895 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 66692012896 GTP-binding protein YchF; Reviewed; Region: PRK09601 66692012897 YchF GTPase; Region: YchF; cd01900 66692012898 G1 box; other site 66692012899 GTP/Mg2+ binding site [chemical binding]; other site 66692012900 Switch I region; other site 66692012901 G2 box; other site 66692012902 Switch II region; other site 66692012903 G3 box; other site 66692012904 G4 box; other site 66692012905 G5 box; other site 66692012906 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 66692012907 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 66692012908 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 66692012909 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 66692012910 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 66692012911 catalytic residue [active] 66692012912 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 66692012913 ParB-like nuclease domain; Region: ParB; smart00470 66692012914 KorB domain; Region: KorB; pfam08535 66692012915 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 66692012916 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 66692012917 P-loop; other site 66692012918 Magnesium ion binding site [ion binding]; other site 66692012919 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 66692012920 ParB-like nuclease domain; Region: ParB; smart00470 66692012921 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 66692012922 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 66692012923 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 66692012924 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 66692012925 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 66692012926 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 66692012927 trmE is a tRNA modification GTPase; Region: trmE; cd04164 66692012928 G1 box; other site 66692012929 GTP/Mg2+ binding site [chemical binding]; other site 66692012930 Switch I region; other site 66692012931 G2 box; other site 66692012932 Switch II region; other site 66692012933 G3 box; other site 66692012934 G4 box; other site 66692012935 G5 box; other site 66692012936 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 66692012937 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 66692012938 Jag N-terminus; Region: Jag_N; pfam14804 66692012939 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 66692012940 G-X-X-G motif; other site 66692012941 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 66692012942 RxxxH motif; other site 66692012943 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 66692012944 ribonuclease P; Reviewed; Region: rnpA; PRK00499 66692012945 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399