-- dump date 20140618_221347 -- class Genbank::misc_feature -- table misc_feature_note -- id note 941639000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 941639000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 941639000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639000004 Walker A motif; other site 941639000005 ATP binding site [chemical binding]; other site 941639000006 Walker B motif; other site 941639000007 arginine finger; other site 941639000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 941639000009 DnaA box-binding interface [nucleotide binding]; other site 941639000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 941639000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 941639000012 putative DNA binding surface [nucleotide binding]; other site 941639000013 dimer interface [polypeptide binding]; other site 941639000014 beta-clamp/clamp loader binding surface; other site 941639000015 beta-clamp/translesion DNA polymerase binding surface; other site 941639000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 941639000017 recombination protein F; Reviewed; Region: recF; PRK00064 941639000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 941639000019 Walker A/P-loop; other site 941639000020 ATP binding site [chemical binding]; other site 941639000021 Q-loop/lid; other site 941639000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639000023 ABC transporter signature motif; other site 941639000024 Walker B; other site 941639000025 D-loop; other site 941639000026 H-loop/switch region; other site 941639000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 941639000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639000029 Mg2+ binding site [ion binding]; other site 941639000030 G-X-G motif; other site 941639000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941639000032 anchoring element; other site 941639000033 dimer interface [polypeptide binding]; other site 941639000034 ATP binding site [chemical binding]; other site 941639000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 941639000036 active site 941639000037 putative metal-binding site [ion binding]; other site 941639000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941639000039 DNA gyrase subunit A; Validated; Region: PRK05560 941639000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941639000041 CAP-like domain; other site 941639000042 active site 941639000043 primary dimer interface [polypeptide binding]; other site 941639000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639000050 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941639000051 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639000052 Zn2+ binding site [ion binding]; other site 941639000053 Mg2+ binding site [ion binding]; other site 941639000054 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 941639000055 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941639000056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941639000057 catalytic residue [active] 941639000058 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941639000059 thymidylate kinase; Validated; Region: tmk; PRK00698 941639000060 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 941639000061 TMP-binding site; other site 941639000062 ATP-binding site [chemical binding]; other site 941639000063 Protein of unknown function (DUF970); Region: DUF970; pfam06153 941639000064 Protein of unknown function (DUF327); Region: DUF327; pfam03885 941639000065 DNA polymerase III subunit delta'; Validated; Region: PRK08058 941639000066 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639000067 Walker A motif; other site 941639000068 ATP binding site [chemical binding]; other site 941639000069 Walker B motif; other site 941639000070 arginine finger; other site 941639000071 RecX family; Region: RecX; cl00936 941639000072 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 941639000073 Protein of unknown function (DUF972); Region: DUF972; pfam06156 941639000074 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 941639000075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639000076 S-adenosylmethionine binding site [chemical binding]; other site 941639000077 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 941639000078 GIY-YIG motif/motif A; other site 941639000079 putative active site [active] 941639000080 putative metal binding site [ion binding]; other site 941639000081 Predicted methyltransferases [General function prediction only]; Region: COG0313 941639000082 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 941639000083 putative SAM binding site [chemical binding]; other site 941639000084 putative homodimer interface [polypeptide binding]; other site 941639000085 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 941639000086 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 941639000087 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 941639000088 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 941639000089 active site 941639000090 HIGH motif; other site 941639000091 KMSKS motif; other site 941639000092 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 941639000093 tRNA binding surface [nucleotide binding]; other site 941639000094 anticodon binding site; other site 941639000095 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 941639000096 dimer interface [polypeptide binding]; other site 941639000097 putative tRNA-binding site [nucleotide binding]; other site 941639000098 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 941639000099 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 941639000100 active site 941639000101 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 941639000102 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 941639000103 putative active site [active] 941639000104 putative metal binding site [ion binding]; other site 941639000105 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 941639000106 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 941639000107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639000108 S-adenosylmethionine binding site [chemical binding]; other site 941639000109 YabG peptidase U57; Region: Peptidase_U57; pfam05582 941639000110 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 941639000111 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941639000112 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 941639000113 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941639000114 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 941639000115 pur operon repressor; Provisional; Region: PRK09213 941639000116 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 941639000117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639000118 active site 941639000119 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 941639000120 homotrimer interaction site [polypeptide binding]; other site 941639000121 putative active site [active] 941639000122 regulatory protein SpoVG; Reviewed; Region: PRK13259 941639000123 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 941639000124 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 941639000125 Substrate binding site; other site 941639000126 Mg++ binding site; other site 941639000127 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 941639000128 active site 941639000129 substrate binding site [chemical binding]; other site 941639000130 CoA binding site [chemical binding]; other site 941639000131 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 941639000132 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 941639000133 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639000134 active site 941639000135 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 941639000136 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 941639000137 5S rRNA interface [nucleotide binding]; other site 941639000138 CTC domain interface [polypeptide binding]; other site 941639000139 L16 interface [polypeptide binding]; other site 941639000140 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 941639000141 putative active site [active] 941639000142 catalytic residue [active] 941639000143 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 941639000144 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 941639000145 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 941639000146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639000147 ATP binding site [chemical binding]; other site 941639000148 putative Mg++ binding site [ion binding]; other site 941639000149 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639000150 nucleotide binding region [chemical binding]; other site 941639000151 ATP-binding site [chemical binding]; other site 941639000152 TRCF domain; Region: TRCF; pfam03461 941639000153 stage V sporulation protein T; Region: spore_V_T; TIGR02851 941639000154 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 941639000155 stage V sporulation protein B; Region: spore_V_B; TIGR02900 941639000156 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 941639000157 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 941639000158 putative homodimer interface [polypeptide binding]; other site 941639000159 putative SAM binding site [chemical binding]; other site 941639000160 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 941639000161 homodimer interface [polypeptide binding]; other site 941639000162 metal binding site [ion binding]; metal-binding site 941639000163 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639000164 RNA binding surface [nucleotide binding]; other site 941639000165 sporulation protein YabP; Region: spore_yabP; TIGR02892 941639000166 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 941639000167 Septum formation initiator; Region: DivIC; pfam04977 941639000168 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 941639000169 hypothetical protein; Provisional; Region: PRK08582 941639000170 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 941639000171 RNA binding site [nucleotide binding]; other site 941639000172 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 941639000173 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639000174 stage II sporulation protein E; Region: spore_II_E; TIGR02865 941639000175 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941639000176 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 941639000177 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 941639000178 metal ion-dependent adhesion site (MIDAS); other site 941639000179 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 941639000180 Catalytic domain of Protein Kinases; Region: PKc; cd00180 941639000181 active site 941639000182 ATP binding site [chemical binding]; other site 941639000183 substrate binding site [chemical binding]; other site 941639000184 activation loop (A-loop); other site 941639000185 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 941639000186 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 941639000187 Ligand Binding Site [chemical binding]; other site 941639000188 TilS substrate binding domain; Region: TilS; pfam09179 941639000189 TilS substrate C-terminal domain; Region: TilS_C; smart00977 941639000190 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639000191 active site 941639000192 FtsH Extracellular; Region: FtsH_ext; pfam06480 941639000193 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 941639000194 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639000195 Walker A motif; other site 941639000196 ATP binding site [chemical binding]; other site 941639000197 Walker B motif; other site 941639000198 arginine finger; other site 941639000199 Peptidase family M41; Region: Peptidase_M41; pfam01434 941639000200 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941639000201 nucleotide binding site [chemical binding]; other site 941639000202 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 941639000203 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 941639000204 dimerization interface [polypeptide binding]; other site 941639000205 domain crossover interface; other site 941639000206 redox-dependent activation switch; other site 941639000207 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941639000208 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941639000209 dimer interface [polypeptide binding]; other site 941639000210 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639000211 catalytic residue [active] 941639000212 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 941639000213 dihydropteroate synthase; Region: DHPS; TIGR01496 941639000214 substrate binding pocket [chemical binding]; other site 941639000215 dimer interface [polypeptide binding]; other site 941639000216 inhibitor binding site; inhibition site 941639000217 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 941639000218 homooctamer interface [polypeptide binding]; other site 941639000219 active site 941639000220 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 941639000221 catalytic center binding site [active] 941639000222 ATP binding site [chemical binding]; other site 941639000223 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 941639000224 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 941639000225 dimer interface [polypeptide binding]; other site 941639000226 putative anticodon binding site; other site 941639000227 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 941639000228 motif 1; other site 941639000229 active site 941639000230 motif 2; other site 941639000231 motif 3; other site 941639000232 YaaC-like Protein; Region: YaaC; pfam14175 941639000233 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 941639000234 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941639000235 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 941639000236 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 941639000237 active site 941639000238 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941639000239 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941639000240 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 941639000241 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 941639000242 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 941639000243 active site 941639000244 multimer interface [polypeptide binding]; other site 941639000245 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 941639000246 predicted active site [active] 941639000247 catalytic triad [active] 941639000248 seryl-tRNA synthetase; Provisional; Region: PRK05431 941639000249 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 941639000250 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 941639000251 dimer interface [polypeptide binding]; other site 941639000252 active site 941639000253 motif 1; other site 941639000254 motif 2; other site 941639000255 motif 3; other site 941639000256 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 941639000257 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 941639000258 Substrate-binding site [chemical binding]; other site 941639000259 Substrate specificity [chemical binding]; other site 941639000260 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 941639000261 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 941639000262 Substrate-binding site [chemical binding]; other site 941639000263 Substrate specificity [chemical binding]; other site 941639000264 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 941639000265 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639000266 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639000267 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 941639000268 active site 941639000269 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 941639000270 nucleoside/Zn binding site; other site 941639000271 dimer interface [polypeptide binding]; other site 941639000272 catalytic motif [active] 941639000273 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 941639000274 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 941639000275 hypothetical protein; Validated; Region: PRK00153 941639000276 recombination protein RecR; Reviewed; Region: recR; PRK00076 941639000277 RecR protein; Region: RecR; pfam02132 941639000278 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 941639000279 putative active site [active] 941639000280 putative metal-binding site [ion binding]; other site 941639000281 tetramer interface [polypeptide binding]; other site 941639000282 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 941639000283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639000284 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639000285 Probable transposase; Region: OrfB_IS605; pfam01385 941639000286 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639000287 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 941639000288 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 941639000289 UvrB/uvrC motif; Region: UVR; pfam02151 941639000290 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 941639000291 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 941639000292 ADP binding site [chemical binding]; other site 941639000293 phosphagen binding site; other site 941639000294 substrate specificity loop; other site 941639000295 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 941639000296 Clp amino terminal domain; Region: Clp_N; pfam02861 941639000297 Clp amino terminal domain; Region: Clp_N; pfam02861 941639000298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639000299 Walker A motif; other site 941639000300 ATP binding site [chemical binding]; other site 941639000301 Walker B motif; other site 941639000302 arginine finger; other site 941639000303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639000304 Walker A motif; other site 941639000305 ATP binding site [chemical binding]; other site 941639000306 Walker B motif; other site 941639000307 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941639000308 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941639000309 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941639000310 Walker A motif; other site 941639000311 ATP binding site [chemical binding]; other site 941639000312 Walker B motif; other site 941639000313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941639000314 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 941639000315 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 941639000316 putative active site [active] 941639000317 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 941639000318 substrate binding site; other site 941639000319 dimer interface; other site 941639000320 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 941639000321 homotrimer interaction site [polypeptide binding]; other site 941639000322 CDP-binding sites; other site 941639000323 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 941639000324 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941639000325 HIGH motif; other site 941639000326 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 941639000327 active site 941639000328 KMSKS motif; other site 941639000329 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 941639000330 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 941639000331 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 941639000332 trimer interface [polypeptide binding]; other site 941639000333 active site 941639000334 substrate binding site [chemical binding]; other site 941639000335 CoA binding site [chemical binding]; other site 941639000336 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 941639000337 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941639000338 active site 941639000339 HIGH motif; other site 941639000340 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 941639000341 KMSKS motif; other site 941639000342 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 941639000343 tRNA binding surface [nucleotide binding]; other site 941639000344 anticodon binding site; other site 941639000345 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 941639000346 active site 941639000347 metal binding site [ion binding]; metal-binding site 941639000348 dimerization interface [polypeptide binding]; other site 941639000349 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 941639000350 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 941639000351 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941639000352 YacP-like NYN domain; Region: NYN_YacP; cl01491 941639000353 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 941639000354 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639000355 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 941639000356 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 941639000357 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766 941639000358 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 941639000359 heterodimer interface [polypeptide binding]; other site 941639000360 homodimer interface [polypeptide binding]; other site 941639000361 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 941639000362 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 941639000363 L7/L12 interface [polypeptide binding]; other site 941639000364 23S rRNA interface [nucleotide binding]; other site 941639000365 L25 interface [polypeptide binding]; other site 941639000366 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 941639000367 mRNA/rRNA interface [nucleotide binding]; other site 941639000368 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 941639000369 23S rRNA interface [nucleotide binding]; other site 941639000370 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 941639000371 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 941639000372 core dimer interface [polypeptide binding]; other site 941639000373 peripheral dimer interface [polypeptide binding]; other site 941639000374 L10 interface [polypeptide binding]; other site 941639000375 L11 interface [polypeptide binding]; other site 941639000376 putative EF-Tu interaction site [polypeptide binding]; other site 941639000377 putative EF-G interaction site [polypeptide binding]; other site 941639000378 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941639000379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639000380 S-adenosylmethionine binding site [chemical binding]; other site 941639000381 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 941639000382 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 941639000383 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 941639000384 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 941639000385 RPB1 interaction site [polypeptide binding]; other site 941639000386 RPB10 interaction site [polypeptide binding]; other site 941639000387 RPB11 interaction site [polypeptide binding]; other site 941639000388 RPB3 interaction site [polypeptide binding]; other site 941639000389 RPB12 interaction site [polypeptide binding]; other site 941639000390 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 941639000391 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 941639000392 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 941639000393 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 941639000394 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 941639000395 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 941639000396 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 941639000397 G-loop; other site 941639000398 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 941639000399 DNA binding site [nucleotide binding] 941639000400 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 941639000401 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 941639000402 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 941639000403 streptomycin interaction site [chemical binding]; other site 941639000404 23S rRNA interaction site [nucleotide binding]; other site 941639000405 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 941639000406 16S rRNA interaction site [nucleotide binding]; other site 941639000407 30S ribosomal protein S7; Validated; Region: PRK05302 941639000408 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941639000409 G4 box; other site 941639000410 G5 box; other site 941639000411 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 941639000412 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 941639000413 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 941639000414 elongation factor Tu; Reviewed; Region: PRK00049 941639000415 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 941639000416 G1 box; other site 941639000417 GEF interaction site [polypeptide binding]; other site 941639000418 GTP/Mg2+ binding site [chemical binding]; other site 941639000419 Switch I region; other site 941639000420 G2 box; other site 941639000421 G3 box; other site 941639000422 Switch II region; other site 941639000423 G4 box; other site 941639000424 G5 box; other site 941639000425 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 941639000426 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 941639000427 Antibiotic Binding Site [chemical binding]; other site 941639000428 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 941639000429 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 941639000430 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 941639000431 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 941639000432 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 941639000433 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 941639000434 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 941639000435 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 941639000436 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 941639000437 putative translocon binding site; other site 941639000438 protein-rRNA interface [nucleotide binding]; other site 941639000439 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 941639000440 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 941639000441 G-X-X-G motif; other site 941639000442 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 941639000443 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 941639000444 23S rRNA interface [nucleotide binding]; other site 941639000445 5S rRNA interface [nucleotide binding]; other site 941639000446 putative antibiotic binding site [chemical binding]; other site 941639000447 L25 interface [polypeptide binding]; other site 941639000448 L27 interface [polypeptide binding]; other site 941639000449 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 941639000450 23S rRNA interface [nucleotide binding]; other site 941639000451 putative translocon interaction site; other site 941639000452 signal recognition particle (SRP54) interaction site; other site 941639000453 L23 interface [polypeptide binding]; other site 941639000454 trigger factor interaction site; other site 941639000455 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 941639000456 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 941639000457 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 941639000458 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 941639000459 RNA binding site [nucleotide binding]; other site 941639000460 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 941639000461 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 941639000462 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 941639000463 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 941639000464 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 941639000465 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 941639000466 23S rRNA interface [nucleotide binding]; other site 941639000467 5S rRNA interface [nucleotide binding]; other site 941639000468 L27 interface [polypeptide binding]; other site 941639000469 L5 interface [polypeptide binding]; other site 941639000470 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 941639000471 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 941639000472 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 941639000473 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 941639000474 23S rRNA binding site [nucleotide binding]; other site 941639000475 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 941639000476 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 941639000477 SecY translocase; Region: SecY; pfam00344 941639000478 adenylate kinase; Reviewed; Region: adk; PRK00279 941639000479 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 941639000480 AMP-binding site [chemical binding]; other site 941639000481 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 941639000482 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 941639000483 rRNA binding site [nucleotide binding]; other site 941639000484 predicted 30S ribosome binding site; other site 941639000485 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 941639000486 30S ribosomal protein S13; Region: bact_S13; TIGR03631 941639000487 30S ribosomal protein S11; Validated; Region: PRK05309 941639000488 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 941639000489 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 941639000490 alphaNTD - beta interaction site [polypeptide binding]; other site 941639000491 alphaNTD - beta' interaction site [polypeptide binding]; other site 941639000492 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 941639000493 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 941639000494 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 941639000495 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941639000496 Walker A/P-loop; other site 941639000497 ATP binding site [chemical binding]; other site 941639000498 Q-loop/lid; other site 941639000499 ABC transporter signature motif; other site 941639000500 Walker B; other site 941639000501 D-loop; other site 941639000502 H-loop/switch region; other site 941639000503 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 941639000504 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941639000505 Walker A/P-loop; other site 941639000506 ATP binding site [chemical binding]; other site 941639000507 Q-loop/lid; other site 941639000508 ABC transporter signature motif; other site 941639000509 Walker B; other site 941639000510 D-loop; other site 941639000511 H-loop/switch region; other site 941639000512 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 941639000513 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 941639000514 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 941639000515 dimerization interface 3.5A [polypeptide binding]; other site 941639000516 active site 941639000517 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 941639000518 23S rRNA interface [nucleotide binding]; other site 941639000519 L3 interface [polypeptide binding]; other site 941639000520 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 941639000521 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 941639000522 ATP-sulfurylase; Region: ATPS; cd00517 941639000523 active site 941639000524 HXXH motif; other site 941639000525 flexible loop; other site 941639000526 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 941639000527 AAA domain; Region: AAA_18; pfam13238 941639000528 ligand-binding site [chemical binding]; other site 941639000529 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 941639000530 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941639000531 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941639000532 active site 941639000533 metal binding site [ion binding]; metal-binding site 941639000534 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 941639000535 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 941639000536 Walker A motif; other site 941639000537 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 941639000538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639000539 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639000540 Probable transposase; Region: OrfB_IS605; pfam01385 941639000541 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639000542 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 941639000543 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 941639000544 active site 941639000545 Helix-turn-helix domain; Region: HTH_18; pfam12833 941639000546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941639000547 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 941639000548 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941639000549 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639000550 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 941639000551 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 941639000552 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 941639000553 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 941639000554 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 941639000555 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639000556 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639000557 Walker A/P-loop; other site 941639000558 ATP binding site [chemical binding]; other site 941639000559 Q-loop/lid; other site 941639000560 ABC transporter signature motif; other site 941639000561 Walker B; other site 941639000562 D-loop; other site 941639000563 H-loop/switch region; other site 941639000564 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 941639000565 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639000566 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 941639000567 Walker A/P-loop; other site 941639000568 ATP binding site [chemical binding]; other site 941639000569 Q-loop/lid; other site 941639000570 ABC transporter signature motif; other site 941639000571 Walker B; other site 941639000572 D-loop; other site 941639000573 H-loop/switch region; other site 941639000574 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 941639000575 Arginase family; Region: Arginase; cd09989 941639000576 agmatinase; Region: agmatinase; TIGR01230 941639000577 active site 941639000578 Mn binding site [ion binding]; other site 941639000579 oligomer interface [polypeptide binding]; other site 941639000580 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 941639000581 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 941639000582 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639000583 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639000584 DNA binding residues [nucleotide binding] 941639000585 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 941639000586 Putative zinc-finger; Region: zf-HC2; pfam13490 941639000587 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 941639000588 Uncharacterized conserved protein [Function unknown]; Region: COG1624 941639000589 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 941639000590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 941639000591 YbbR-like protein; Region: YbbR; pfam07949 941639000592 YbbR-like protein; Region: YbbR; pfam07949 941639000593 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 941639000594 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 941639000595 active site 941639000596 substrate binding site [chemical binding]; other site 941639000597 metal binding site [ion binding]; metal-binding site 941639000598 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 941639000599 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 941639000600 glutaminase active site [active] 941639000601 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941639000602 dimer interface [polypeptide binding]; other site 941639000603 active site 941639000604 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941639000605 dimer interface [polypeptide binding]; other site 941639000606 active site 941639000607 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941639000608 active site 941639000609 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 941639000610 active site 2 [active] 941639000611 active site 1 [active] 941639000612 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639000613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639000614 putative substrate translocation pore; other site 941639000615 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941639000616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639000617 putative substrate translocation pore; other site 941639000618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941639000619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941639000620 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941639000621 dimerization interface [polypeptide binding]; other site 941639000622 NAD-dependent deacetylase; Provisional; Region: PRK00481 941639000623 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 941639000624 NAD+ binding site [chemical binding]; other site 941639000625 substrate binding site [chemical binding]; other site 941639000626 Zn binding site [ion binding]; other site 941639000627 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639000628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639000629 dimer interface [polypeptide binding]; other site 941639000630 putative CheW interface [polypeptide binding]; other site 941639000631 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 941639000632 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 941639000633 Uncharacterized conserved protein [Function unknown]; Region: COG3595 941639000634 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 941639000635 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 941639000636 Cache domain; Region: Cache_2; cl07034 941639000637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639000638 dimerization interface [polypeptide binding]; other site 941639000639 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639000640 dimer interface [polypeptide binding]; other site 941639000641 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639000642 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639000643 dimer interface [polypeptide binding]; other site 941639000644 putative CheW interface [polypeptide binding]; other site 941639000645 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 941639000646 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 941639000647 CAAX protease self-immunity; Region: Abi; cl00558 941639000648 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 941639000649 homodimer interface [polypeptide binding]; other site 941639000650 catalytic residues [active] 941639000651 NAD binding site [chemical binding]; other site 941639000652 substrate binding pocket [chemical binding]; other site 941639000653 flexible flap; other site 941639000654 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 941639000655 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 941639000656 dimer interface [polypeptide binding]; other site 941639000657 active site 941639000658 putative acyltransferase; Provisional; Region: PRK05790 941639000659 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941639000660 dimer interface [polypeptide binding]; other site 941639000661 active site 941639000662 DsrE/DsrF-like family; Region: DrsE; pfam02635 941639000663 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 941639000664 ligand binding site [chemical binding]; other site 941639000665 dimerization interface [polypeptide binding]; other site 941639000666 NADP binding site [chemical binding]; other site 941639000667 catalytic site [active] 941639000668 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 941639000669 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 941639000670 Walker A/P-loop; other site 941639000671 ATP binding site [chemical binding]; other site 941639000672 Q-loop/lid; other site 941639000673 ABC transporter signature motif; other site 941639000674 Walker B; other site 941639000675 D-loop; other site 941639000676 H-loop/switch region; other site 941639000677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639000678 ABC-ATPase subunit interface; other site 941639000679 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 941639000680 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941639000681 HPr interaction site; other site 941639000682 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941639000683 active site 941639000684 phosphorylation site [posttranslational modification] 941639000685 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 941639000686 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941639000687 active site turn [active] 941639000688 phosphorylation site [posttranslational modification] 941639000689 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941639000690 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 941639000691 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 941639000692 Ca binding site [ion binding]; other site 941639000693 active site 941639000694 catalytic site [active] 941639000695 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 941639000696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639000697 DNA-binding site [nucleotide binding]; DNA binding site 941639000698 UTRA domain; Region: UTRA; pfam07702 941639000699 fructuronate transporter; Provisional; Region: PRK10034; cl15264 941639000700 GntP family permease; Region: GntP_permease; pfam02447 941639000701 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 941639000702 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 941639000703 N- and C-terminal domain interface [polypeptide binding]; other site 941639000704 active site 941639000705 catalytic site [active] 941639000706 metal binding site [ion binding]; metal-binding site 941639000707 carbohydrate binding site [chemical binding]; other site 941639000708 ATP binding site [chemical binding]; other site 941639000709 Transcriptional regulators [Transcription]; Region: GntR; COG1802 941639000710 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639000711 DNA-binding site [nucleotide binding]; DNA binding site 941639000712 FCD domain; Region: FCD; pfam07729 941639000713 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 941639000714 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941639000715 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941639000716 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 941639000717 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 941639000718 GIY-YIG motif/motif A; other site 941639000719 active site 941639000720 catalytic site [active] 941639000721 putative DNA binding site [nucleotide binding]; other site 941639000722 metal binding site [ion binding]; metal-binding site 941639000723 UvrB/uvrC motif; Region: UVR; pfam02151 941639000724 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941639000725 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941639000726 ligand binding site [chemical binding]; other site 941639000727 flexible hinge region; other site 941639000728 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941639000729 putative switch regulator; other site 941639000730 non-specific DNA interactions [nucleotide binding]; other site 941639000731 DNA binding site [nucleotide binding] 941639000732 sequence specific DNA binding site [nucleotide binding]; other site 941639000733 putative cAMP binding site [chemical binding]; other site 941639000734 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 941639000735 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941639000736 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 941639000737 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941639000738 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639000739 metal-binding site [ion binding] 941639000740 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 941639000741 Class I ribonucleotide reductase; Region: RNR_I; cd01679 941639000742 active site 941639000743 dimer interface [polypeptide binding]; other site 941639000744 catalytic residues [active] 941639000745 effector binding site; other site 941639000746 R2 peptide binding site; other site 941639000747 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941639000748 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 941639000749 diiron center [ion binding]; other site 941639000750 putative radical transfer pathway; other site 941639000751 dimer interface [polypeptide binding]; other site 941639000752 tyrosyl radical; other site 941639000753 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 941639000754 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 941639000755 active site 941639000756 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941639000757 CoenzymeA binding site [chemical binding]; other site 941639000758 subunit interaction site [polypeptide binding]; other site 941639000759 PHB binding site; other site 941639000760 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 941639000761 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 941639000762 hypothetical protein; Provisional; Region: PRK10621 941639000763 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941639000764 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941639000765 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941639000766 ABC-ATPase subunit interface; other site 941639000767 dimer interface [polypeptide binding]; other site 941639000768 putative PBP binding regions; other site 941639000769 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941639000770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941639000771 ABC-ATPase subunit interface; other site 941639000772 dimer interface [polypeptide binding]; other site 941639000773 putative PBP binding regions; other site 941639000774 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941639000775 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941639000776 intersubunit interface [polypeptide binding]; other site 941639000777 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941639000778 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941639000779 Walker A/P-loop; other site 941639000780 ATP binding site [chemical binding]; other site 941639000781 Q-loop/lid; other site 941639000782 ABC transporter signature motif; other site 941639000783 Walker B; other site 941639000784 D-loop; other site 941639000785 H-loop/switch region; other site 941639000786 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 941639000787 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639000788 hypothetical protein; Provisional; Region: PRK12378 941639000789 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 941639000790 succinic semialdehyde dehydrogenase; Region: PLN02278 941639000791 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 941639000792 tetramerization interface [polypeptide binding]; other site 941639000793 NAD(P) binding site [chemical binding]; other site 941639000794 catalytic residues [active] 941639000795 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 941639000796 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 941639000797 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 941639000798 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 941639000799 Active Sites [active] 941639000800 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 941639000801 diphthine synthase; Region: dph5; TIGR00522 941639000802 active site 941639000803 SAM binding site [chemical binding]; other site 941639000804 homodimer interface [polypeptide binding]; other site 941639000805 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 941639000806 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 941639000807 putative active site [active] 941639000808 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 941639000809 putative active site [active] 941639000810 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 941639000811 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 941639000812 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 941639000813 putative deacylase active site [active] 941639000814 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 941639000815 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 941639000816 dimer interface [polypeptide binding]; other site 941639000817 active site 941639000818 metal binding site [ion binding]; metal-binding site 941639000819 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 941639000820 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 941639000821 acyl-activating enzyme (AAE) consensus motif; other site 941639000822 putative active site [active] 941639000823 AMP binding site [chemical binding]; other site 941639000824 putative CoA binding site [chemical binding]; other site 941639000825 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941639000826 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941639000827 metal binding site [ion binding]; metal-binding site 941639000828 active site 941639000829 I-site; other site 941639000830 EamA-like transporter family; Region: EamA; pfam00892 941639000831 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941639000832 EamA-like transporter family; Region: EamA; pfam00892 941639000833 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 941639000834 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 941639000835 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 941639000836 glutaminase active site [active] 941639000837 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 941639000838 dimer interface [polypeptide binding]; other site 941639000839 active site 941639000840 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 941639000841 dimer interface [polypeptide binding]; other site 941639000842 active site 941639000843 mevalonate kinase; Region: mevalon_kin; TIGR00549 941639000844 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941639000845 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 941639000846 diphosphomevalonate decarboxylase; Region: PLN02407 941639000847 mevalonate kinase; Region: mevalon_kin; TIGR00549 941639000848 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 941639000849 NADH(P)-binding; Region: NAD_binding_10; pfam13460 941639000850 NAD(P) binding site [chemical binding]; other site 941639000851 putative active site [active] 941639000852 potential frameshift: common BLAST hit: gi|288937295|ref|YP_003441354.1| Sigma 54 interacting domain protein 941639000853 Fic family protein [Function unknown]; Region: COG3177 941639000854 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 941639000855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639000856 Walker B motif; other site 941639000857 arginine finger; other site 941639000858 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 941639000859 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639000860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639000861 homodimer interface [polypeptide binding]; other site 941639000862 catalytic residue [active] 941639000863 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 941639000864 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 941639000865 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 941639000866 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 941639000867 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 941639000868 tetramer interface [polypeptide binding]; other site 941639000869 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941639000870 active site 941639000871 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 941639000872 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639000873 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639000874 active site 941639000875 catalytic tetrad [active] 941639000876 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 941639000877 putative FMN binding site [chemical binding]; other site 941639000878 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 941639000879 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 941639000880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639000881 putative substrate translocation pore; other site 941639000882 POT family; Region: PTR2; pfam00854 941639000883 lysine transporter; Provisional; Region: PRK10836 941639000884 Cupin domain; Region: Cupin_2; pfam07883 941639000885 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 941639000886 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 941639000887 Walker A/P-loop; other site 941639000888 ATP binding site [chemical binding]; other site 941639000889 Q-loop/lid; other site 941639000890 ABC transporter signature motif; other site 941639000891 Walker B; other site 941639000892 D-loop; other site 941639000893 H-loop/switch region; other site 941639000894 TOBE domain; Region: TOBE_2; pfam08402 941639000895 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941639000896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639000897 dimer interface [polypeptide binding]; other site 941639000898 conserved gate region; other site 941639000899 putative PBP binding loops; other site 941639000900 ABC-ATPase subunit interface; other site 941639000901 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 941639000902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639000903 dimer interface [polypeptide binding]; other site 941639000904 conserved gate region; other site 941639000905 putative PBP binding loops; other site 941639000906 ABC-ATPase subunit interface; other site 941639000907 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 941639000908 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 941639000909 TPR repeat; Region: TPR_11; pfam13414 941639000910 amino acid transporter; Region: 2A0306; TIGR00909 941639000911 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 941639000912 Uncharacterized conserved protein [Function unknown]; Region: COG1556 941639000913 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 941639000914 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 941639000915 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 941639000916 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 941639000917 Cysteine-rich domain; Region: CCG; pfam02754 941639000918 Cysteine-rich domain; Region: CCG; pfam02754 941639000919 histidine-histamine antiporter; Region: his_histam_anti; TIGR04298 941639000920 Spore germination protein; Region: Spore_permease; cl17796 941639000921 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 941639000922 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 941639000923 dimer interface [polypeptide binding]; other site 941639000924 active site 941639000925 metal binding site [ion binding]; metal-binding site 941639000926 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 941639000927 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 941639000928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639000929 ATP binding site [chemical binding]; other site 941639000930 Mg2+ binding site [ion binding]; other site 941639000931 G-X-G motif; other site 941639000932 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 941639000933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639000934 active site 941639000935 phosphorylation site [posttranslational modification] 941639000936 intermolecular recognition site; other site 941639000937 dimerization interface [polypeptide binding]; other site 941639000938 Transcriptional regulator; Region: CitT; pfam12431 941639000939 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 941639000940 Citrate transporter; Region: CitMHS; pfam03600 941639000941 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 941639000942 Putative Catalytic site; other site 941639000943 DXD motif; other site 941639000944 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 941639000945 Part of AAA domain; Region: AAA_19; pfam13245 941639000946 Family description; Region: UvrD_C_2; pfam13538 941639000947 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 941639000948 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 941639000949 amphipathic channel; other site 941639000950 Asn-Pro-Ala signature motifs; other site 941639000951 glycerol kinase; Provisional; Region: glpK; PRK00047 941639000952 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 941639000953 N- and C-terminal domain interface [polypeptide binding]; other site 941639000954 active site 941639000955 MgATP binding site [chemical binding]; other site 941639000956 catalytic site [active] 941639000957 metal binding site [ion binding]; metal-binding site 941639000958 glycerol binding site [chemical binding]; other site 941639000959 homotetramer interface [polypeptide binding]; other site 941639000960 homodimer interface [polypeptide binding]; other site 941639000961 FBP binding site [chemical binding]; other site 941639000962 protein IIAGlc interface [polypeptide binding]; other site 941639000963 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 941639000964 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 941639000965 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941639000966 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941639000967 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 941639000968 ligand binding site [chemical binding]; other site 941639000969 flexible hinge region; other site 941639000970 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941639000971 non-specific DNA interactions [nucleotide binding]; other site 941639000972 DNA binding site [nucleotide binding] 941639000973 sequence specific DNA binding site [nucleotide binding]; other site 941639000974 putative cAMP binding site [chemical binding]; other site 941639000975 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 941639000976 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 941639000977 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 941639000978 Uncharacterized conserved protein [Function unknown]; Region: COG2353 941639000979 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941639000980 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 941639000981 putative active site [active] 941639000982 putative FMN binding site [chemical binding]; other site 941639000983 putative substrate binding site [chemical binding]; other site 941639000984 putative catalytic residue [active] 941639000985 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 941639000986 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639000987 Zn2+ binding site [ion binding]; other site 941639000988 Mg2+ binding site [ion binding]; other site 941639000989 glycyl-tRNA synthetase; Provisional; Region: PRK04173 941639000990 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941639000991 motif 1; other site 941639000992 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 941639000993 active site 941639000994 motif 2; other site 941639000995 motif 3; other site 941639000996 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 941639000997 anticodon binding site; other site 941639000998 Amino acid permease; Region: AA_permease_2; pfam13520 941639000999 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 941639001000 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 941639001001 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941639001002 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941639001003 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941639001004 ABC transporter; Region: ABC_tran; pfam00005 941639001005 Q-loop/lid; other site 941639001006 ABC transporter signature motif; other site 941639001007 Walker B; other site 941639001008 D-loop; other site 941639001009 H-loop/switch region; other site 941639001010 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941639001011 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639001012 substrate binding pocket [chemical binding]; other site 941639001013 membrane-bound complex binding site; other site 941639001014 hinge residues; other site 941639001015 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941639001016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001017 dimer interface [polypeptide binding]; other site 941639001018 conserved gate region; other site 941639001019 putative PBP binding loops; other site 941639001020 ABC-ATPase subunit interface; other site 941639001021 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941639001022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001023 dimer interface [polypeptide binding]; other site 941639001024 conserved gate region; other site 941639001025 putative PBP binding loops; other site 941639001026 ABC-ATPase subunit interface; other site 941639001027 Predicted transcriptional regulators [Transcription]; Region: COG1725 941639001028 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639001029 DNA-binding site [nucleotide binding]; DNA binding site 941639001030 Predicted membrane protein [General function prediction only]; Region: COG4194 941639001031 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 941639001032 Predicted transcriptional regulators [Transcription]; Region: COG1733 941639001033 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 941639001034 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941639001035 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941639001036 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 941639001037 active site 941639001038 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 941639001039 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 941639001040 Transcriptional regulator [Transcription]; Region: LytR; COG1316 941639001041 potential frameshift: common BLAST hit: gi|239826241|ref|YP_002948865.1| bifunctional homocysteine 941639001042 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 941639001043 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 941639001044 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 941639001045 FAD binding site [chemical binding]; other site 941639001046 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 941639001047 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 941639001048 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 941639001049 substrate binding pocket [chemical binding]; other site 941639001050 dimer interface [polypeptide binding]; other site 941639001051 inhibitor binding site; inhibition site 941639001052 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 941639001053 B12 binding site [chemical binding]; other site 941639001054 cobalt ligand [ion binding]; other site 941639001055 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 941639001056 CsbD-like; Region: CsbD; cl17424 941639001057 ComK protein; Region: ComK; cl11560 941639001058 RNA polymerase factor sigma-70; Validated; Region: PRK06759 941639001059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639001060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 941639001061 DNA binding residues [nucleotide binding] 941639001062 Chain length determinant protein; Region: Wzz; cl15801 941639001063 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 941639001064 AAA domain; Region: AAA_31; pfam13614 941639001065 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941639001066 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 941639001067 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 941639001068 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 941639001069 active site 941639001070 tetramer interface; other site 941639001071 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 941639001072 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 941639001073 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 941639001074 NAD(P) binding site [chemical binding]; other site 941639001075 homodimer interface [polypeptide binding]; other site 941639001076 substrate binding site [chemical binding]; other site 941639001077 active site 941639001078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639001079 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 941639001080 NAD(P) binding site [chemical binding]; other site 941639001081 active site 941639001082 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 941639001083 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941639001084 putative ADP-binding pocket [chemical binding]; other site 941639001085 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941639001086 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 941639001087 putative ADP-binding pocket [chemical binding]; other site 941639001088 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 941639001089 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 941639001090 Probable Catalytic site; other site 941639001091 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 941639001092 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 941639001093 putative NAD(P) binding site [chemical binding]; other site 941639001094 active site 941639001095 putative substrate binding site [chemical binding]; other site 941639001096 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 941639001097 Transposase [DNA replication, recombination, and repair]; Region: COG5421 941639001098 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 941639001099 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 941639001100 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 941639001101 substrate binding site; other site 941639001102 tetramer interface; other site 941639001103 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 941639001104 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 941639001105 NADP binding site [chemical binding]; other site 941639001106 active site 941639001107 putative substrate binding site [chemical binding]; other site 941639001108 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 941639001109 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 941639001110 NAD binding site [chemical binding]; other site 941639001111 substrate binding site [chemical binding]; other site 941639001112 homodimer interface [polypeptide binding]; other site 941639001113 active site 941639001114 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 941639001115 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 941639001116 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941639001117 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 941639001118 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 941639001119 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 941639001120 active site 941639001121 NTP binding site [chemical binding]; other site 941639001122 metal binding triad [ion binding]; metal-binding site 941639001123 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 941639001124 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941639001125 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 941639001126 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 941639001127 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 941639001128 N- and C-terminal domain interface [polypeptide binding]; other site 941639001129 D-xylulose kinase; Region: XylB; TIGR01312 941639001130 active site 941639001131 MgATP binding site [chemical binding]; other site 941639001132 catalytic site [active] 941639001133 metal binding site [ion binding]; metal-binding site 941639001134 xylulose binding site [chemical binding]; other site 941639001135 homodimer interface [polypeptide binding]; other site 941639001136 Peptidase M30; Region: Peptidase_M30; pfam10460 941639001137 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 941639001138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639001139 non-specific DNA binding site [nucleotide binding]; other site 941639001140 salt bridge; other site 941639001141 sequence-specific DNA binding site [nucleotide binding]; other site 941639001142 Domain of unknown function (DUF955); Region: DUF955; cl01076 941639001143 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 941639001144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001145 putative substrate translocation pore; other site 941639001146 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 941639001147 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 941639001148 N- and C-terminal domain interface [polypeptide binding]; other site 941639001149 putative active site [active] 941639001150 MgATP binding site [chemical binding]; other site 941639001151 catalytic site [active] 941639001152 metal binding site [ion binding]; metal-binding site 941639001153 putative xylulose binding site [chemical binding]; other site 941639001154 putative homodimer interface [polypeptide binding]; other site 941639001155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639001156 short chain dehydrogenase; Provisional; Region: PRK06114 941639001157 NAD(P) binding site [chemical binding]; other site 941639001158 active site 941639001159 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 941639001160 putative DNA binding site [nucleotide binding]; other site 941639001161 putative Zn2+ binding site [ion binding]; other site 941639001162 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 941639001163 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941639001164 nucleotide binding site [chemical binding]; other site 941639001165 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941639001166 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 941639001167 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941639001168 NAD binding site [chemical binding]; other site 941639001169 catalytic Zn binding site [ion binding]; other site 941639001170 structural Zn binding site [ion binding]; other site 941639001171 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 941639001172 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941639001173 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941639001174 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639001175 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639001176 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639001177 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639001178 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 941639001179 Lysozyme subfamily 2; Region: LYZ2; smart00047 941639001180 Bacterial SH3 domain; Region: SH3_3; cl17532 941639001181 Bacterial SH3 domain; Region: SH3_3; cl17532 941639001182 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 941639001183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941639001184 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 941639001185 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 941639001186 active site 941639001187 catalytic site [active] 941639001188 HipA-like C-terminal domain; Region: HipA_C; pfam07804 941639001189 HipA N-terminal domain; Region: Couple_hipA; cl11853 941639001190 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 941639001191 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 941639001192 Zn2+ binding site [ion binding]; other site 941639001193 intersubunit interface [polypeptide binding]; other site 941639001194 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 941639001195 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941639001196 FMN binding site [chemical binding]; other site 941639001197 substrate binding site [chemical binding]; other site 941639001198 putative catalytic residue [active] 941639001199 Protein of unknown function (DUF419); Region: DUF419; pfam04237 941639001200 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 941639001201 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 941639001202 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 941639001203 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 941639001204 Radical SAM superfamily; Region: Radical_SAM; pfam04055 941639001205 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 941639001206 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 941639001207 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 941639001208 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 941639001209 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941639001210 Transcriptional regulator [Transcription]; Region: LytR; COG1316 941639001211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639001212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639001213 active site 941639001214 catalytic tetrad [active] 941639001215 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 941639001216 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 941639001217 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 941639001218 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 941639001219 Prostaglandin dehydrogenases; Region: PGDH; cd05288 941639001220 dimer interface [polypeptide binding]; other site 941639001221 NAD(P) binding site [chemical binding]; other site 941639001222 substrate binding site [chemical binding]; other site 941639001223 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639001224 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639001225 Probable transposase; Region: OrfB_IS605; pfam01385 941639001226 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639001227 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001228 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639001229 putative substrate translocation pore; other site 941639001230 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 941639001231 HTH domain; Region: HTH_11; pfam08279 941639001232 Mga helix-turn-helix domain; Region: Mga; pfam05043 941639001233 PRD domain; Region: PRD; pfam00874 941639001234 PRD domain; Region: PRD; pfam00874 941639001235 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 941639001236 active site 941639001237 P-loop; other site 941639001238 phosphorylation site [posttranslational modification] 941639001239 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941639001240 active site 941639001241 phosphorylation site [posttranslational modification] 941639001242 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 941639001243 active site 941639001244 P-loop; other site 941639001245 phosphorylation site [posttranslational modification] 941639001246 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 941639001247 active site 941639001248 methionine cluster; other site 941639001249 phosphorylation site [posttranslational modification] 941639001250 metal binding site [ion binding]; metal-binding site 941639001251 Uncharacterized conserved protein [Function unknown]; Region: COG3589 941639001252 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 941639001253 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 941639001254 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 941639001255 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 941639001256 potential frameshift: common BLAST hit: gi|217965972|ref|YP_002351650.1| amino-domain protein 941639001257 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 941639001258 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 941639001259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001261 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941639001262 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941639001263 putative Zn2+ binding site [ion binding]; other site 941639001264 putative DNA binding site [nucleotide binding]; other site 941639001265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639001267 putative substrate translocation pore; other site 941639001268 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 941639001269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639001270 DNA binding site [nucleotide binding] 941639001271 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 941639001272 putative dimerization interface [polypeptide binding]; other site 941639001273 putative ligand binding site [chemical binding]; other site 941639001274 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 941639001275 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 941639001276 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 941639001277 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 941639001278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001279 dimer interface [polypeptide binding]; other site 941639001280 conserved gate region; other site 941639001281 putative PBP binding loops; other site 941639001282 ABC-ATPase subunit interface; other site 941639001283 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 941639001284 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 941639001285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001286 dimer interface [polypeptide binding]; other site 941639001287 conserved gate region; other site 941639001288 putative PBP binding loops; other site 941639001289 ABC-ATPase subunit interface; other site 941639001290 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 941639001291 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 941639001292 Walker A/P-loop; other site 941639001293 ATP binding site [chemical binding]; other site 941639001294 Q-loop/lid; other site 941639001295 ABC transporter signature motif; other site 941639001296 Walker B; other site 941639001297 D-loop; other site 941639001298 H-loop/switch region; other site 941639001299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 941639001300 Predicted transcriptional regulators [Transcription]; Region: COG1510 941639001301 MarR family; Region: MarR_2; pfam12802 941639001302 maltose O-acetyltransferase; Provisional; Region: PRK10092 941639001303 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 941639001304 active site 941639001305 substrate binding site [chemical binding]; other site 941639001306 trimer interface [polypeptide binding]; other site 941639001307 CoA binding site [chemical binding]; other site 941639001308 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 941639001309 active site 941639001310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639001311 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639001312 Probable transposase; Region: OrfB_IS605; pfam01385 941639001313 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639001314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639001315 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 941639001316 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 941639001317 active site 941639001318 catalytic triad [active] 941639001319 oxyanion hole [active] 941639001320 Transposase; Region: DEDD_Tnp_IS110; pfam01548 941639001321 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 941639001322 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 941639001323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941639001324 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 941639001325 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 941639001326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639001327 Walker A motif; other site 941639001328 ATP binding site [chemical binding]; other site 941639001329 Walker B motif; other site 941639001330 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 941639001331 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 941639001332 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 941639001333 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 941639001334 putative active site [active] 941639001335 metal binding site [ion binding]; metal-binding site 941639001336 quinolinate synthetase; Provisional; Region: PRK09375 941639001337 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 941639001338 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 941639001339 dimerization interface [polypeptide binding]; other site 941639001340 active site 941639001341 L-aspartate oxidase; Provisional; Region: PRK08071 941639001342 L-aspartate oxidase; Provisional; Region: PRK06175 941639001343 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 941639001344 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 941639001345 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941639001346 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941639001347 catalytic residue [active] 941639001348 LabA_like proteins; Region: LabA_like; cd06167 941639001349 Uncharacterized conserved protein [Function unknown]; Region: COG1432 941639001350 putative metal binding site [ion binding]; other site 941639001351 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 941639001352 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 941639001353 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 941639001354 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941639001355 Walker A/P-loop; other site 941639001356 ATP binding site [chemical binding]; other site 941639001357 Q-loop/lid; other site 941639001358 ABC transporter signature motif; other site 941639001359 Walker B; other site 941639001360 D-loop; other site 941639001361 H-loop/switch region; other site 941639001362 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 941639001363 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 941639001364 Walker A/P-loop; other site 941639001365 ATP binding site [chemical binding]; other site 941639001366 Q-loop/lid; other site 941639001367 ABC transporter signature motif; other site 941639001368 Walker B; other site 941639001369 D-loop; other site 941639001370 H-loop/switch region; other site 941639001371 hypothetical protein; Provisional; Region: PRK13661 941639001372 Uncharacterized conserved protein [Function unknown]; Region: COG1912 941639001373 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 941639001374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639001375 NAD(P) binding site [chemical binding]; other site 941639001376 active site 941639001377 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 941639001378 fructuronate transporter; Provisional; Region: PRK10034; cl15264 941639001379 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 941639001380 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 941639001381 tetrameric interface [polypeptide binding]; other site 941639001382 NAD binding site [chemical binding]; other site 941639001383 catalytic residues [active] 941639001384 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 941639001385 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 941639001386 putative active site [active] 941639001387 metal binding site [ion binding]; metal-binding site 941639001388 FOG: CBS domain [General function prediction only]; Region: COG0517 941639001389 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 941639001390 PAS fold; Region: PAS; pfam00989 941639001391 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639001392 putative active site [active] 941639001393 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 941639001394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639001395 Walker A motif; other site 941639001396 ATP binding site [chemical binding]; other site 941639001397 Walker B motif; other site 941639001398 arginine finger; other site 941639001399 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941639001400 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 941639001401 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 941639001402 octaprenyl-diphosphate synthase; Region: PLN02857 941639001403 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941639001404 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 941639001405 active site 941639001406 catalytic site [active] 941639001407 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941639001408 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 941639001409 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 941639001410 Walker A/P-loop; other site 941639001411 ATP binding site [chemical binding]; other site 941639001412 Q-loop/lid; other site 941639001413 ABC transporter signature motif; other site 941639001414 Walker B; other site 941639001415 D-loop; other site 941639001416 H-loop/switch region; other site 941639001417 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 941639001418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001419 dimer interface [polypeptide binding]; other site 941639001420 conserved gate region; other site 941639001421 ABC-ATPase subunit interface; other site 941639001422 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 941639001423 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001424 dimer interface [polypeptide binding]; other site 941639001425 conserved gate region; other site 941639001426 ABC-ATPase subunit interface; other site 941639001427 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 941639001428 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639001429 substrate binding pocket [chemical binding]; other site 941639001430 membrane-bound complex binding site; other site 941639001431 hinge residues; other site 941639001432 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 941639001433 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 941639001434 active site 941639001435 metal binding site [ion binding]; metal-binding site 941639001436 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 941639001437 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 941639001438 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 941639001439 oligomer interface [polypeptide binding]; other site 941639001440 active site 941639001441 metal binding site [ion binding]; metal-binding site 941639001442 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 941639001443 L-lactate permease; Region: Lactate_perm; cl00701 941639001444 Transcriptional regulators [Transcription]; Region: FadR; COG2186 941639001445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639001446 DNA-binding site [nucleotide binding]; DNA binding site 941639001447 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 941639001448 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 941639001449 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639001450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639001451 homodimer interface [polypeptide binding]; other site 941639001452 catalytic residue [active] 941639001453 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 941639001454 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639001455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001457 tartrate dehydrogenase; Provisional; Region: PRK08194 941639001458 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 941639001459 YvrJ protein family; Region: YvrJ; pfam12841 941639001460 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 941639001461 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 941639001462 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 941639001463 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 941639001464 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 941639001465 methionine cluster; other site 941639001466 active site 941639001467 phosphorylation site [posttranslational modification] 941639001468 metal binding site [ion binding]; metal-binding site 941639001469 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 941639001470 active site 941639001471 P-loop; other site 941639001472 phosphorylation site [posttranslational modification] 941639001473 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 941639001474 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 941639001475 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 941639001476 beta-galactosidase; Region: BGL; TIGR03356 941639001477 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 941639001478 HTH domain; Region: HTH_11; pfam08279 941639001479 Mga helix-turn-helix domain; Region: Mga; pfam05043 941639001480 PRD domain; Region: PRD; pfam00874 941639001481 PRD domain; Region: PRD; pfam00874 941639001482 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 941639001483 active site 941639001484 P-loop; other site 941639001485 phosphorylation site [posttranslational modification] 941639001486 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941639001487 active site 941639001488 phosphorylation site [posttranslational modification] 941639001489 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 941639001490 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 941639001491 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 941639001492 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 941639001493 putative active site [active] 941639001494 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 941639001495 cystathionine gamma-synthase; Reviewed; Region: PRK08247 941639001496 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941639001497 homodimer interface [polypeptide binding]; other site 941639001498 substrate-cofactor binding pocket; other site 941639001499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639001500 catalytic residue [active] 941639001501 cystathionine beta-lyase; Provisional; Region: PRK08064 941639001502 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941639001503 homodimer interface [polypeptide binding]; other site 941639001504 substrate-cofactor binding pocket; other site 941639001505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639001506 catalytic residue [active] 941639001507 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 941639001508 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 941639001509 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 941639001510 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 941639001511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941639001512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 941639001513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001514 dimer interface [polypeptide binding]; other site 941639001515 conserved gate region; other site 941639001516 putative PBP binding loops; other site 941639001517 ABC-ATPase subunit interface; other site 941639001518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001519 dimer interface [polypeptide binding]; other site 941639001520 conserved gate region; other site 941639001521 putative PBP binding loops; other site 941639001522 ABC-ATPase subunit interface; other site 941639001523 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 941639001524 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941639001525 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941639001526 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941639001527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941639001528 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 941639001529 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 941639001530 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 941639001531 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941639001532 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 941639001533 NAD(P) binding site [chemical binding]; other site 941639001534 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 941639001535 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 941639001536 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 941639001537 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 941639001538 active site 941639001539 substrate binding site [chemical binding]; other site 941639001540 metal binding site [ion binding]; metal-binding site 941639001541 Predicted integral membrane protein [Function unknown]; Region: COG5652 941639001542 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 941639001543 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 941639001544 Walker A/P-loop; other site 941639001545 ATP binding site [chemical binding]; other site 941639001546 Q-loop/lid; other site 941639001547 ABC transporter signature motif; other site 941639001548 Walker B; other site 941639001549 D-loop; other site 941639001550 H-loop/switch region; other site 941639001551 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941639001552 classical (c) SDRs; Region: SDR_c; cd05233 941639001553 NAD(P) binding site [chemical binding]; other site 941639001554 active site 941639001555 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 941639001556 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 941639001557 Subunit I/III interface [polypeptide binding]; other site 941639001558 Subunit III/IV interface [polypeptide binding]; other site 941639001559 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 941639001560 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 941639001561 D-pathway; other site 941639001562 Putative ubiquinol binding site [chemical binding]; other site 941639001563 Low-spin heme (heme b) binding site [chemical binding]; other site 941639001564 Putative water exit pathway; other site 941639001565 Binuclear center (heme o3/CuB) [ion binding]; other site 941639001566 K-pathway; other site 941639001567 Putative proton exit pathway; other site 941639001568 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 941639001569 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 941639001570 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941639001571 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639001572 motif II; other site 941639001573 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 941639001574 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941639001575 HlyD family secretion protein; Region: HlyD_3; pfam13437 941639001576 HTH-like domain; Region: HTH_21; pfam13276 941639001577 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 941639001578 Integrase core domain; Region: rve; pfam00665 941639001579 Integrase core domain; Region: rve_2; pfam13333 941639001580 beta-phosphoglucomutase; Region: bPGM; TIGR01990 941639001581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639001582 motif II; other site 941639001583 maltose phosphorylase; Provisional; Region: PRK13807 941639001584 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 941639001585 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 941639001586 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 941639001587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639001589 putative substrate translocation pore; other site 941639001590 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941639001591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639001592 DNA binding site [nucleotide binding] 941639001593 domain linker motif; other site 941639001594 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941639001595 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941639001596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639001597 dimer interface [polypeptide binding]; other site 941639001598 phosphorylation site [posttranslational modification] 941639001599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639001600 ATP binding site [chemical binding]; other site 941639001601 Mg2+ binding site [ion binding]; other site 941639001602 G-X-G motif; other site 941639001603 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 941639001604 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 941639001605 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 941639001606 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 941639001607 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941639001608 NAD binding site [chemical binding]; other site 941639001609 dimer interface [polypeptide binding]; other site 941639001610 substrate binding site [chemical binding]; other site 941639001611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 941639001612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 941639001613 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 941639001614 HD domain; Region: HD_4; pfam13328 941639001615 Predicted membrane protein [Function unknown]; Region: COG1511 941639001616 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941639001617 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 941639001618 Domain of unknown function DUF77; Region: DUF77; pfam01910 941639001619 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 941639001620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639001621 binding surface 941639001622 TPR motif; other site 941639001623 Dynamin family; Region: Dynamin_N; pfam00350 941639001624 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941639001625 G3 box; other site 941639001626 Switch II region; other site 941639001627 GTP/Mg2+ binding site [chemical binding]; other site 941639001628 G4 box; other site 941639001629 G5 box; other site 941639001630 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 941639001631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639001632 Walker A motif; other site 941639001633 ATP binding site [chemical binding]; other site 941639001634 Walker B motif; other site 941639001635 arginine finger; other site 941639001636 Transcriptional antiterminator [Transcription]; Region: COG3933 941639001637 PRD domain; Region: PRD; pfam00874 941639001638 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 941639001639 active pocket/dimerization site; other site 941639001640 active site 941639001641 phosphorylation site [posttranslational modification] 941639001642 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 941639001643 active site 941639001644 phosphorylation site [posttranslational modification] 941639001645 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 941639001646 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 941639001647 active pocket/dimerization site; other site 941639001648 active site 941639001649 phosphorylation site [posttranslational modification] 941639001650 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 941639001651 active site 941639001652 phosphorylation site [posttranslational modification] 941639001653 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 941639001654 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 941639001655 Domain of unknown function (DUF956); Region: DUF956; pfam06115 941639001656 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 941639001657 dimer interface [polypeptide binding]; other site 941639001658 Citrate synthase; Region: Citrate_synt; pfam00285 941639001659 active site 941639001660 coenzyme A binding site [chemical binding]; other site 941639001661 citrylCoA binding site [chemical binding]; other site 941639001662 oxalacetate/citrate binding site [chemical binding]; other site 941639001663 catalytic triad [active] 941639001664 2-methylcitrate dehydratase; Region: prpD; TIGR02330 941639001665 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 941639001666 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 941639001667 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941639001668 tetramer interface [polypeptide binding]; other site 941639001669 active site 941639001670 Mg2+/Mn2+ binding site [ion binding]; other site 941639001671 Heat induced stress protein YflT; Region: YflT; pfam11181 941639001672 Amidase; Region: Amidase; cl11426 941639001673 amidase; Provisional; Region: PRK06529 941639001674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639001675 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639001676 Probable transposase; Region: OrfB_IS605; pfam01385 941639001677 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639001678 Domain of unknown function DUF77; Region: DUF77; pfam01910 941639001679 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941639001680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639001681 dimer interface [polypeptide binding]; other site 941639001682 conserved gate region; other site 941639001683 putative PBP binding loops; other site 941639001684 ABC-ATPase subunit interface; other site 941639001685 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941639001686 NMT1/THI5 like; Region: NMT1; pfam09084 941639001687 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941639001688 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941639001689 Walker A/P-loop; other site 941639001690 ATP binding site [chemical binding]; other site 941639001691 Q-loop/lid; other site 941639001692 ABC transporter signature motif; other site 941639001693 Walker B; other site 941639001694 D-loop; other site 941639001695 H-loop/switch region; other site 941639001696 homoserine kinase; Provisional; Region: PRK01212 941639001697 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941639001698 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 941639001699 threonine synthase; Reviewed; Region: PRK06721 941639001700 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 941639001701 homodimer interface [polypeptide binding]; other site 941639001702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639001703 catalytic residue [active] 941639001704 homoserine dehydrogenase; Provisional; Region: PRK06349 941639001705 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941639001706 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 941639001707 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 941639001708 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 941639001709 active site 941639001710 metal binding site [ion binding]; metal-binding site 941639001711 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 941639001712 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 941639001713 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 941639001714 putative substrate binding site [chemical binding]; other site 941639001715 putative ATP binding site [chemical binding]; other site 941639001716 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 941639001717 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 941639001718 active site 941639001719 tetramer interface; other site 941639001720 Protein of unknown function (DUF997); Region: DUF997; pfam06196 941639001721 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 941639001722 Na binding site [ion binding]; other site 941639001723 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941639001724 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 941639001725 Cl binding site [ion binding]; other site 941639001726 oligomer interface [polypeptide binding]; other site 941639001727 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 941639001728 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 941639001729 putative catalytic cysteine [active] 941639001730 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 941639001731 putative active site [active] 941639001732 metal binding site [ion binding]; metal-binding site 941639001733 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941639001734 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941639001735 putative Mg++ binding site [ion binding]; other site 941639001736 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639001737 nucleotide binding region [chemical binding]; other site 941639001738 ATP-binding site [chemical binding]; other site 941639001739 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941639001740 active site 941639001741 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 941639001742 short chain dehydrogenase; Provisional; Region: PRK06701 941639001743 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 941639001744 NAD binding site [chemical binding]; other site 941639001745 metal binding site [ion binding]; metal-binding site 941639001746 active site 941639001747 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 941639001748 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 941639001749 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941639001750 Ligand Binding Site [chemical binding]; other site 941639001751 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 941639001752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639001753 FeS/SAM binding site; other site 941639001754 YfkB-like domain; Region: YfkB; pfam08756 941639001755 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 941639001756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941639001757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639001758 DNA binding site [nucleotide binding] 941639001759 domain linker motif; other site 941639001760 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 941639001761 putative dimerization interface [polypeptide binding]; other site 941639001762 putative ligand binding site [chemical binding]; other site 941639001763 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 941639001764 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941639001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639001766 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941639001767 active site 941639001768 motif I; other site 941639001769 motif II; other site 941639001770 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941639001771 Esterase/lipase [General function prediction only]; Region: COG1647 941639001772 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 941639001773 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941639001774 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941639001775 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639001776 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639001777 active site 941639001778 catalytic tetrad [active] 941639001779 Predicted flavoprotein [General function prediction only]; Region: COG0431 941639001780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941639001781 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639001782 non-specific DNA binding site [nucleotide binding]; other site 941639001783 salt bridge; other site 941639001784 sequence-specific DNA binding site [nucleotide binding]; other site 941639001785 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 941639001786 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 941639001787 active site 941639001788 metal binding site [ion binding]; metal-binding site 941639001789 DNA binding site [nucleotide binding] 941639001790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639001791 AAA domain; Region: AAA_27; pfam13514 941639001792 Walker A/P-loop; other site 941639001793 ATP binding site [chemical binding]; other site 941639001794 Q-loop/lid; other site 941639001795 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 941639001796 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941639001797 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941639001798 MATE family multidrug exporter; Provisional; Region: PRK10189 941639001799 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 941639001800 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 941639001801 aspartate aminotransferase; Provisional; Region: PRK06836 941639001802 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639001803 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639001804 homodimer interface [polypeptide binding]; other site 941639001805 catalytic residue [active] 941639001806 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 941639001807 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 941639001808 Melibiase; Region: Melibiase; pfam02065 941639001809 acyl carrier protein; Provisional; Region: acpP; PRK00982 941639001810 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 941639001811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639001812 S-adenosylmethionine binding site [chemical binding]; other site 941639001813 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 941639001814 Low molecular weight phosphatase family; Region: LMWPc; cl00105 941639001815 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 941639001816 arsenical-resistance protein; Region: acr3; TIGR00832 941639001817 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 941639001818 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 941639001819 P loop; other site 941639001820 Nucleotide binding site [chemical binding]; other site 941639001821 DTAP/Switch II; other site 941639001822 Switch I; other site 941639001823 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 941639001824 P loop; other site 941639001825 Nucleotide binding site [chemical binding]; other site 941639001826 DTAP/Switch II; other site 941639001827 Switch I; other site 941639001828 Protein of unknown function DUF262; Region: DUF262; pfam03235 941639001829 Uncharacterized conserved protein [Function unknown]; Region: COG1479 941639001830 Uncharacterized conserved protein [Function unknown]; Region: COG1479 941639001831 Protein of unknown function DUF262; Region: DUF262; pfam03235 941639001832 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 941639001833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639001834 Methyltransferase domain; Region: Methyltransf_31; pfam13847 941639001835 S-adenosylmethionine binding site [chemical binding]; other site 941639001836 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639001837 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 941639001838 active site 941639001839 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 941639001840 TIGR01777 family protein; Region: yfcH 941639001841 putative NAD(P) binding site [chemical binding]; other site 941639001842 putative active site [active] 941639001843 Putative transcription activator [Transcription]; Region: TenA; COG0819 941639001844 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 941639001845 Transposase domain (DUF772); Region: DUF772; pfam05598 941639001846 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639001847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639001848 active site 941639001849 motif I; other site 941639001850 motif II; other site 941639001851 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941639001852 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 941639001853 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 941639001854 Predicted transcriptional regulator [Transcription]; Region: COG4189 941639001855 galactokinase; Provisional; Region: PRK05322 941639001856 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 941639001857 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 941639001858 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 941639001859 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 941639001860 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 941639001861 NAD binding site [chemical binding]; other site 941639001862 homodimer interface [polypeptide binding]; other site 941639001863 active site 941639001864 substrate binding site [chemical binding]; other site 941639001865 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 941639001866 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 941639001867 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 941639001868 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 941639001869 active site 941639001870 catalytic residues [active] 941639001871 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 941639001872 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639001873 DNA binding site [nucleotide binding] 941639001874 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 941639001875 putative dimerization interface [polypeptide binding]; other site 941639001876 putative ligand binding site [chemical binding]; other site 941639001877 Cold-inducible protein YdjO; Region: YdjO; pfam14169 941639001878 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 941639001879 S1 domain; Region: S1_2; pfam13509 941639001880 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 941639001881 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 941639001882 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941639001883 putative metal binding site [ion binding]; other site 941639001884 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 941639001885 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 941639001886 Homoserine O-succinyltransferase; Region: HTS; pfam04204 941639001887 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 941639001888 proposed active site lysine [active] 941639001889 conserved cys residue [active] 941639001890 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941639001891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639001892 putative substrate translocation pore; other site 941639001893 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 941639001894 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 941639001895 active site 941639001896 dimer interface [polypeptide binding]; other site 941639001897 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 941639001898 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 941639001899 active site 941639001900 trimer interface [polypeptide binding]; other site 941639001901 allosteric site; other site 941639001902 active site lid [active] 941639001903 hexamer (dimer of trimers) interface [polypeptide binding]; other site 941639001904 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941639001905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639001906 DNA-binding site [nucleotide binding]; DNA binding site 941639001907 UTRA domain; Region: UTRA; pfam07702 941639001908 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639001909 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639001910 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941639001911 NlpC/P60 family; Region: NLPC_P60; pfam00877 941639001912 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639001913 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639001914 dimer interface [polypeptide binding]; other site 941639001915 putative CheW interface [polypeptide binding]; other site 941639001916 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 941639001917 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 941639001918 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941639001919 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941639001920 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 941639001921 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 941639001922 Mg++ binding site [ion binding]; other site 941639001923 putative catalytic motif [active] 941639001924 substrate binding site [chemical binding]; other site 941639001925 Uncharacterized conserved protein [Function unknown]; Region: COG1739 941639001926 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 941639001927 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 941639001928 Sensor protein DegS; Region: DegS; pfam05384 941639001929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 941639001930 Histidine kinase; Region: HisKA_3; pfam07730 941639001931 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639001932 ATP binding site [chemical binding]; other site 941639001933 Mg2+ binding site [ion binding]; other site 941639001934 G-X-G motif; other site 941639001935 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 941639001936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639001937 active site 941639001938 phosphorylation site [posttranslational modification] 941639001939 intermolecular recognition site; other site 941639001940 dimerization interface [polypeptide binding]; other site 941639001941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941639001942 DNA binding residues [nucleotide binding] 941639001943 dimerization interface [polypeptide binding]; other site 941639001944 amino acid transporter; Region: 2A0306; TIGR00909 941639001945 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 941639001946 EDD domain protein, DegV family; Region: DegV; TIGR00762 941639001947 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941639001948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639001949 ATP binding site [chemical binding]; other site 941639001950 putative Mg++ binding site [ion binding]; other site 941639001951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639001952 nucleotide binding region [chemical binding]; other site 941639001953 ATP-binding site [chemical binding]; other site 941639001954 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 941639001955 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639001956 active site 941639001957 flagellar operon protein TIGR03826; Region: YvyF 941639001958 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 941639001959 FlgN protein; Region: FlgN; pfam05130 941639001960 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 941639001961 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941639001962 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 941639001963 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941639001964 flagellar assembly protein FliW; Provisional; Region: PRK13285 941639001965 carbon storage regulator; Provisional; Region: PRK01712 941639001966 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 941639001967 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 941639001968 AAA domain; Region: AAA_32; pfam13654 941639001969 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941639001970 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 941639001971 active site 941639001972 DNA binding site [nucleotide binding] 941639001973 FlaG protein; Region: FlaG; cl00591 941639001974 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 941639001975 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 941639001976 flagellar protein FliS; Validated; Region: fliS; PRK05685 941639001977 Flagellar protein FliT; Region: FliT; pfam05400 941639001978 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 941639001979 30S subunit binding site; other site 941639001980 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 941639001981 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 941639001982 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 941639001983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941639001984 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 941639001985 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639001986 nucleotide binding region [chemical binding]; other site 941639001987 ATP-binding site [chemical binding]; other site 941639001988 SEC-C motif; Region: SEC-C; pfam02810 941639001989 peptide chain release factor 2; Provisional; Region: PRK06746 941639001990 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941639001991 RF-1 domain; Region: RF-1; pfam00472 941639001992 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941639001993 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941639001994 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941639001995 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941639001996 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941639001997 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 941639001998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639001999 Walker A/P-loop; other site 941639002000 ATP binding site [chemical binding]; other site 941639002001 Q-loop/lid; other site 941639002002 ABC transporter signature motif; other site 941639002003 Walker B; other site 941639002004 D-loop; other site 941639002005 H-loop/switch region; other site 941639002006 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 941639002007 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 941639002008 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 941639002009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 941639002010 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941639002011 Peptidase family M23; Region: Peptidase_M23; pfam01551 941639002012 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 941639002013 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 941639002014 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 941639002015 putative active site [active] 941639002016 catalytic site [active] 941639002017 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 941639002018 putative active site [active] 941639002019 catalytic site [active] 941639002020 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 941639002021 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941639002022 homodimer interface [polypeptide binding]; other site 941639002023 substrate-cofactor binding pocket; other site 941639002024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639002025 catalytic residue [active] 941639002026 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 941639002027 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 941639002028 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 941639002029 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 941639002030 C-terminal peptidase (prc); Region: prc; TIGR00225 941639002031 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 941639002032 protein binding site [polypeptide binding]; other site 941639002033 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 941639002034 Catalytic dyad [active] 941639002035 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941639002036 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941639002037 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941639002038 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941639002039 ABC-ATPase subunit interface; other site 941639002040 dimer interface [polypeptide binding]; other site 941639002041 putative PBP binding regions; other site 941639002042 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 941639002043 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941639002044 ABC-ATPase subunit interface; other site 941639002045 dimer interface [polypeptide binding]; other site 941639002046 putative PBP binding regions; other site 941639002047 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 941639002048 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941639002049 Walker A/P-loop; other site 941639002050 ATP binding site [chemical binding]; other site 941639002051 Q-loop/lid; other site 941639002052 ABC transporter signature motif; other site 941639002053 Walker B; other site 941639002054 D-loop; other site 941639002055 H-loop/switch region; other site 941639002056 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 941639002057 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 941639002058 putative ligand binding residues [chemical binding]; other site 941639002059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 941639002060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639002061 dimerization interface [polypeptide binding]; other site 941639002062 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639002063 putative active site [active] 941639002064 heme pocket [chemical binding]; other site 941639002065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639002066 dimer interface [polypeptide binding]; other site 941639002067 phosphorylation site [posttranslational modification] 941639002068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639002069 ATP binding site [chemical binding]; other site 941639002070 Mg2+ binding site [ion binding]; other site 941639002071 G-X-G motif; other site 941639002072 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639002073 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639002074 active site 941639002075 phosphorylation site [posttranslational modification] 941639002076 intermolecular recognition site; other site 941639002077 dimerization interface [polypeptide binding]; other site 941639002078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639002079 DNA binding site [nucleotide binding] 941639002080 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 941639002081 4Fe-4S binding domain; Region: Fer4; cl02805 941639002082 protoporphyrinogen oxidase; Provisional; Region: PRK12416 941639002083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639002084 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941639002085 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639002086 Transposase domain (DUF772); Region: DUF772; pfam05598 941639002087 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639002088 benzoate transport; Region: 2A0115; TIGR00895 941639002089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639002090 putative substrate translocation pore; other site 941639002091 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 941639002092 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 941639002093 DNA interaction; other site 941639002094 Metal-binding active site; metal-binding site 941639002095 AP (apurinic/apyrimidinic) site pocket; other site 941639002096 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 941639002097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639002098 active site 941639002099 motif I; other site 941639002100 motif II; other site 941639002101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639002102 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941639002103 MgtC family; Region: MgtC; pfam02308 941639002104 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 941639002105 potential frameshift: common BLAST hit: gi|134301069|ref|YP_001114565.1| transposase, IS4 family protein 941639002106 PBP superfamily domain; Region: PBP_like_2; cl17296 941639002107 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941639002108 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 941639002109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639002110 dimer interface [polypeptide binding]; other site 941639002111 conserved gate region; other site 941639002112 putative PBP binding loops; other site 941639002113 ABC-ATPase subunit interface; other site 941639002114 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 941639002115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639002116 dimer interface [polypeptide binding]; other site 941639002117 conserved gate region; other site 941639002118 putative PBP binding loops; other site 941639002119 ABC-ATPase subunit interface; other site 941639002120 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 941639002121 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941639002122 Walker A/P-loop; other site 941639002123 ATP binding site [chemical binding]; other site 941639002124 Q-loop/lid; other site 941639002125 ABC transporter signature motif; other site 941639002126 Walker B; other site 941639002127 D-loop; other site 941639002128 H-loop/switch region; other site 941639002129 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 941639002130 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 941639002131 Walker A/P-loop; other site 941639002132 ATP binding site [chemical binding]; other site 941639002133 Q-loop/lid; other site 941639002134 ABC transporter signature motif; other site 941639002135 Walker B; other site 941639002136 D-loop; other site 941639002137 H-loop/switch region; other site 941639002138 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 941639002139 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 941639002140 Ligand binding site; other site 941639002141 Putative Catalytic site; other site 941639002142 DXD motif; other site 941639002143 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 941639002144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639002145 Zn2+ binding site [ion binding]; other site 941639002146 Mg2+ binding site [ion binding]; other site 941639002147 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 941639002148 excinuclease ABC subunit B; Provisional; Region: PRK05298 941639002149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639002150 ATP binding site [chemical binding]; other site 941639002151 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639002152 nucleotide binding region [chemical binding]; other site 941639002153 ATP-binding site [chemical binding]; other site 941639002154 Ultra-violet resistance protein B; Region: UvrB; pfam12344 941639002155 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 941639002156 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941639002157 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 941639002158 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 941639002159 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 941639002160 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 941639002161 active site 941639002162 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 941639002163 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 941639002164 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 941639002165 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 941639002166 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 941639002167 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 941639002168 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 941639002169 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 941639002170 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941639002171 SH3-like domain; Region: SH3_8; pfam13457 941639002172 SH3-like domain; Region: SH3_8; pfam13457 941639002173 SH3-like domain; Region: SH3_8; pfam13457 941639002174 SH3-like domain; Region: SH3_8; pfam13457 941639002175 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 941639002176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941639002177 putative ADP-binding pocket [chemical binding]; other site 941639002178 Uncharacterized conserved protein [Function unknown]; Region: COG3595 941639002179 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 941639002180 Membrane protein of unknown function; Region: DUF360; cl00850 941639002181 HPr kinase/phosphorylase; Provisional; Region: PRK05428 941639002182 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 941639002183 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 941639002184 Hpr binding site; other site 941639002185 active site 941639002186 homohexamer subunit interaction site [polypeptide binding]; other site 941639002187 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 941639002188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639002189 motif II; other site 941639002190 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 941639002191 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 941639002192 trimer interface [polypeptide binding]; other site 941639002193 active site 941639002194 substrate binding site [chemical binding]; other site 941639002195 CoA binding site [chemical binding]; other site 941639002196 TPR repeat; Region: TPR_11; pfam13414 941639002197 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639002198 binding surface 941639002199 TPR motif; other site 941639002200 TPR repeat; Region: TPR_11; pfam13414 941639002201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639002202 binding surface 941639002203 TPR motif; other site 941639002204 Tetratricopeptide repeat; Region: TPR_16; pfam13432 941639002205 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 941639002206 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941639002207 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639002208 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 941639002209 putative active site [active] 941639002210 nucleotide binding site [chemical binding]; other site 941639002211 nudix motif; other site 941639002212 putative metal binding site [ion binding]; other site 941639002213 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 941639002214 AAA domain; Region: AAA_18; pfam13238 941639002215 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 941639002216 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 941639002217 phosphate binding site [ion binding]; other site 941639002218 putative substrate binding pocket [chemical binding]; other site 941639002219 dimer interface [polypeptide binding]; other site 941639002220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 941639002221 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 941639002222 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941639002223 dimerization domain swap beta strand [polypeptide binding]; other site 941639002224 regulatory protein interface [polypeptide binding]; other site 941639002225 active site 941639002226 regulatory phosphorylation site [posttranslational modification]; other site 941639002227 Clp protease; Region: CLP_protease; pfam00574 941639002228 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 941639002229 oligomer interface [polypeptide binding]; other site 941639002230 active site residues [active] 941639002231 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 941639002232 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 941639002233 fumarate hydratase; Reviewed; Region: fumC; PRK00485 941639002234 Class II fumarases; Region: Fumarase_classII; cd01362 941639002235 active site 941639002236 tetramer interface [polypeptide binding]; other site 941639002237 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941639002238 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 941639002239 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941639002240 Walker A/P-loop; other site 941639002241 ATP binding site [chemical binding]; other site 941639002242 Q-loop/lid; other site 941639002243 ABC transporter signature motif; other site 941639002244 Walker B; other site 941639002245 D-loop; other site 941639002246 H-loop/switch region; other site 941639002247 TOBE domain; Region: TOBE; pfam03459 941639002248 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 941639002249 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 941639002250 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 941639002251 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 941639002252 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 941639002253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 941639002254 hypothetical protein; Provisional; Region: PRK13676 941639002255 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941639002256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 941639002257 motif I; other site 941639002258 motif II; other site 941639002259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 941639002260 motif II; other site 941639002261 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941639002262 phenylacetate degradation probable enoyl-CoA hydratase paaB; Region: PaaB1; TIGR02280 941639002263 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941639002264 substrate binding site [chemical binding]; other site 941639002265 oxyanion hole (OAH) forming residues; other site 941639002266 trimer interface [polypeptide binding]; other site 941639002267 YhzD-like protein; Region: YhzD; pfam14120 941639002268 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 941639002269 Predicted permeases [General function prediction only]; Region: COG0701 941639002270 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 941639002271 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 941639002272 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 941639002273 active site 941639002274 metal binding site [ion binding]; metal-binding site 941639002275 DNA binding site [nucleotide binding] 941639002276 Uncharacterized conserved protein [Function unknown]; Region: COG4717 941639002277 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 941639002278 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 941639002279 generic binding surface II; other site 941639002280 generic binding surface I; other site 941639002281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639002282 Zn2+ binding site [ion binding]; other site 941639002283 Mg2+ binding site [ion binding]; other site 941639002284 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 941639002285 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 941639002286 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 941639002287 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 941639002288 transcriptional regulator Hpr; Provisional; Region: PRK13777 941639002289 MarR family; Region: MarR; pfam01047 941639002290 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 941639002291 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 941639002292 HIT family signature motif; other site 941639002293 catalytic residue [active] 941639002294 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 941639002295 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941639002296 Walker A/P-loop; other site 941639002297 ATP binding site [chemical binding]; other site 941639002298 Q-loop/lid; other site 941639002299 ABC transporter signature motif; other site 941639002300 Walker B; other site 941639002301 D-loop; other site 941639002302 H-loop/switch region; other site 941639002303 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 941639002304 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941639002305 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 941639002306 metal binding site [ion binding]; metal-binding site 941639002307 dimer interface [polypeptide binding]; other site 941639002308 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 941639002309 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 941639002310 substrate binding site [chemical binding]; other site 941639002311 active site 941639002312 ferrochelatase; Provisional; Region: PRK12435 941639002313 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 941639002314 C-terminal domain interface [polypeptide binding]; other site 941639002315 active site 941639002316 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 941639002317 active site 941639002318 N-terminal domain interface [polypeptide binding]; other site 941639002319 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 941639002320 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941639002321 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941639002322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941639002323 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941639002324 Predicted membrane protein [Function unknown]; Region: COG1511 941639002325 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 941639002326 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 941639002327 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 941639002328 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 941639002329 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 941639002330 EamA-like transporter family; Region: EamA; pfam00892 941639002331 EamA-like transporter family; Region: EamA; pfam00892 941639002332 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941639002333 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 941639002334 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 941639002335 Cu(I) binding site [ion binding]; other site 941639002336 YtkA-like; Region: YtkA; pfam13115 941639002337 YhfH-like protein; Region: YhfH; pfam14149 941639002338 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 941639002339 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 941639002340 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 941639002341 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 941639002342 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 941639002343 acyl-activating enzyme (AAE) consensus motif; other site 941639002344 putative AMP binding site [chemical binding]; other site 941639002345 putative active site [active] 941639002346 putative CoA binding site [chemical binding]; other site 941639002347 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 941639002348 Peptidase family M48; Region: Peptidase_M48; pfam01435 941639002349 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 941639002350 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 941639002351 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 941639002352 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 941639002353 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 941639002354 Part of AAA domain; Region: AAA_19; pfam13245 941639002355 Family description; Region: UvrD_C_2; pfam13538 941639002356 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 941639002357 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 941639002358 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 941639002359 Spore germination protein GerPC; Region: GerPC; pfam10737 941639002360 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 941639002361 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 941639002362 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 941639002363 Predicted membrane protein [Function unknown]; Region: COG2311 941639002364 Protein of unknown function (DUF418); Region: DUF418; pfam04235 941639002365 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 941639002366 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 941639002367 hypothetical protein; Provisional; Region: PRK13673 941639002368 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 941639002369 EDD domain protein, DegV family; Region: DegV; TIGR00762 941639002370 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 941639002371 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 941639002372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639002373 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941639002374 active site 941639002375 motif I; other site 941639002376 motif II; other site 941639002377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639002378 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 941639002379 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 941639002380 Clp amino terminal domain; Region: Clp_N; pfam02861 941639002381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639002382 Walker A motif; other site 941639002383 ATP binding site [chemical binding]; other site 941639002384 Walker B motif; other site 941639002385 arginine finger; other site 941639002386 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639002387 Walker A motif; other site 941639002388 ATP binding site [chemical binding]; other site 941639002389 Walker B motif; other site 941639002390 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941639002391 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 941639002392 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639002393 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 941639002394 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 941639002395 dimer interface [polypeptide binding]; other site 941639002396 active site 941639002397 CoA binding pocket [chemical binding]; other site 941639002398 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 941639002399 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 941639002400 dimer interface [polypeptide binding]; other site 941639002401 active site 941639002402 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 941639002403 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941639002404 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941639002405 Walker A/P-loop; other site 941639002406 ATP binding site [chemical binding]; other site 941639002407 Q-loop/lid; other site 941639002408 ABC transporter signature motif; other site 941639002409 Walker B; other site 941639002410 D-loop; other site 941639002411 H-loop/switch region; other site 941639002412 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941639002413 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941639002414 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941639002415 Walker A/P-loop; other site 941639002416 ATP binding site [chemical binding]; other site 941639002417 Q-loop/lid; other site 941639002418 ABC transporter signature motif; other site 941639002419 Walker B; other site 941639002420 D-loop; other site 941639002421 H-loop/switch region; other site 941639002422 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941639002423 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941639002424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639002425 dimer interface [polypeptide binding]; other site 941639002426 conserved gate region; other site 941639002427 putative PBP binding loops; other site 941639002428 ABC-ATPase subunit interface; other site 941639002429 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941639002430 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941639002431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639002432 dimer interface [polypeptide binding]; other site 941639002433 conserved gate region; other site 941639002434 putative PBP binding loops; other site 941639002435 ABC-ATPase subunit interface; other site 941639002436 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 941639002437 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 941639002438 peptide binding site [polypeptide binding]; other site 941639002439 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 941639002440 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 941639002441 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 941639002442 active site 941639002443 HIGH motif; other site 941639002444 dimer interface [polypeptide binding]; other site 941639002445 KMSKS motif; other site 941639002446 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 941639002447 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941639002448 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 941639002449 peptide binding site [polypeptide binding]; other site 941639002450 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941639002451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639002452 dimer interface [polypeptide binding]; other site 941639002453 conserved gate region; other site 941639002454 putative PBP binding loops; other site 941639002455 ABC-ATPase subunit interface; other site 941639002456 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941639002457 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 941639002458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639002459 dimer interface [polypeptide binding]; other site 941639002460 conserved gate region; other site 941639002461 putative PBP binding loops; other site 941639002462 ABC-ATPase subunit interface; other site 941639002463 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941639002464 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941639002465 Walker A/P-loop; other site 941639002466 ATP binding site [chemical binding]; other site 941639002467 Q-loop/lid; other site 941639002468 ABC transporter signature motif; other site 941639002469 Walker B; other site 941639002470 D-loop; other site 941639002471 H-loop/switch region; other site 941639002472 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 941639002473 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 941639002474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941639002475 Walker A/P-loop; other site 941639002476 ATP binding site [chemical binding]; other site 941639002477 Q-loop/lid; other site 941639002478 ABC transporter signature motif; other site 941639002479 Walker B; other site 941639002480 D-loop; other site 941639002481 H-loop/switch region; other site 941639002482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 941639002483 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 941639002484 ArsC family; Region: ArsC; pfam03960 941639002485 putative catalytic residues [active] 941639002486 thiol/disulfide switch; other site 941639002487 adaptor protein; Provisional; Region: PRK02315 941639002488 Competence protein CoiA-like family; Region: CoiA; cl11541 941639002489 oligoendopeptidase F; Region: pepF; TIGR00181 941639002490 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 941639002491 active site 941639002492 Zn binding site [ion binding]; other site 941639002493 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 941639002494 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 941639002495 catalytic residues [active] 941639002496 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 941639002497 apolar tunnel; other site 941639002498 heme binding site [chemical binding]; other site 941639002499 dimerization interface [polypeptide binding]; other site 941639002500 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 941639002501 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941639002502 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941639002503 catalytic residue [active] 941639002504 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 941639002505 putative active site [active] 941639002506 putative metal binding residues [ion binding]; other site 941639002507 signature motif; other site 941639002508 putative triphosphate binding site [ion binding]; other site 941639002509 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941639002510 synthetase active site [active] 941639002511 NTP binding site [chemical binding]; other site 941639002512 metal binding site [ion binding]; metal-binding site 941639002513 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 941639002514 ATP-NAD kinase; Region: NAD_kinase; pfam01513 941639002515 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 941639002516 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941639002517 active site 941639002518 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 941639002519 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 941639002520 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 941639002521 NAD binding site [chemical binding]; other site 941639002522 homotetramer interface [polypeptide binding]; other site 941639002523 homodimer interface [polypeptide binding]; other site 941639002524 substrate binding site [chemical binding]; other site 941639002525 active site 941639002526 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 941639002527 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 941639002528 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 941639002529 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 941639002530 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 941639002531 stage V sporulation protein AD; Provisional; Region: PRK12404 941639002532 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 941639002533 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 941639002534 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 941639002535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941639002536 hypothetical protein; Provisional; Region: PRK13679 941639002537 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941639002538 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 941639002539 Putative esterase; Region: Esterase; pfam00756 941639002540 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 941639002541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941639002542 nucleotide binding site [chemical binding]; other site 941639002543 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941639002544 classical (c) SDRs; Region: SDR_c; cd05233 941639002545 NAD(P) binding site [chemical binding]; other site 941639002546 active site 941639002547 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 941639002548 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 941639002549 Walker A/P-loop; other site 941639002550 ATP binding site [chemical binding]; other site 941639002551 Q-loop/lid; other site 941639002552 ABC transporter signature motif; other site 941639002553 Walker B; other site 941639002554 D-loop; other site 941639002555 H-loop/switch region; other site 941639002556 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 941639002557 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 941639002558 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 941639002559 trimer interface [polypeptide binding]; other site 941639002560 active site 941639002561 G bulge; other site 941639002562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639002563 putative substrate translocation pore; other site 941639002564 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639002565 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 941639002566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639002567 Coenzyme A binding pocket [chemical binding]; other site 941639002568 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 941639002569 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 941639002570 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 941639002571 acyl-activating enzyme (AAE) consensus motif; other site 941639002572 putative AMP binding site [chemical binding]; other site 941639002573 putative active site [active] 941639002574 putative CoA binding site [chemical binding]; other site 941639002575 Chromate transporter; Region: Chromate_transp; cl17781 941639002576 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 941639002577 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 941639002578 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941639002579 putative DNA binding site [nucleotide binding]; other site 941639002580 putative Zn2+ binding site [ion binding]; other site 941639002581 AsnC family; Region: AsnC_trans_reg; pfam01037 941639002582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639002583 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639002584 putative substrate translocation pore; other site 941639002585 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 941639002586 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 941639002587 Amidase; Region: Amidase; cl11426 941639002588 indole-3-acetamide amidohydrolase; Region: PLN02722 941639002589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639002590 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639002591 putative substrate translocation pore; other site 941639002592 Sensory domain found in PocR; Region: PocR; pfam10114 941639002593 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 941639002594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941639002595 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 941639002596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941639002597 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 941639002598 propionate/acetate kinase; Provisional; Region: PRK12379 941639002599 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 941639002600 substrate binding site [chemical binding]; other site 941639002601 THF binding site; other site 941639002602 zinc-binding site [ion binding]; other site 941639002603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 941639002604 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 941639002605 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941639002606 WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266 941639002607 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 941639002608 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 941639002609 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 941639002610 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 941639002611 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 941639002612 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941639002613 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941639002614 type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197 941639002615 LXG domain of WXG superfamily; Region: LXG; pfam04740 941639002616 LXG domain of WXG superfamily; Region: LXG; pfam04740 941639002617 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941639002618 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639002619 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 941639002620 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 941639002621 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 941639002622 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 941639002623 NAD binding site [chemical binding]; other site 941639002624 proline/glycine betaine transporter; Provisional; Region: PRK10642 941639002625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639002626 putative substrate translocation pore; other site 941639002627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639002628 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639002629 Probable transposase; Region: OrfB_IS605; pfam01385 941639002630 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639002631 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 941639002632 Transcriptional regulator; Region: Rrf2; cl17282 941639002633 Rrf2 family protein; Region: rrf2_super; TIGR00738 941639002634 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 941639002635 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 941639002636 heme-binding site [chemical binding]; other site 941639002637 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 941639002638 FAD binding pocket [chemical binding]; other site 941639002639 FAD binding motif [chemical binding]; other site 941639002640 phosphate binding motif [ion binding]; other site 941639002641 beta-alpha-beta structure motif; other site 941639002642 NAD binding pocket [chemical binding]; other site 941639002643 Heme binding pocket [chemical binding]; other site 941639002644 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941639002645 Ferritin-like domain; Region: Ferritin; pfam00210 941639002646 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 941639002647 dimerization interface [polypeptide binding]; other site 941639002648 DPS ferroxidase diiron center [ion binding]; other site 941639002649 ion pore; other site 941639002650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 941639002651 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 941639002652 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 941639002653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639002654 PAS domain; Region: PAS_9; pfam13426 941639002655 putative active site [active] 941639002656 heme pocket [chemical binding]; other site 941639002657 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941639002658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639002659 dimer interface [polypeptide binding]; other site 941639002660 phosphorylation site [posttranslational modification] 941639002661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639002662 ATP binding site [chemical binding]; other site 941639002663 Mg2+ binding site [ion binding]; other site 941639002664 G-X-G motif; other site 941639002665 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 941639002666 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 941639002667 G1 box; other site 941639002668 putative GEF interaction site [polypeptide binding]; other site 941639002669 GTP/Mg2+ binding site [chemical binding]; other site 941639002670 Switch I region; other site 941639002671 G2 box; other site 941639002672 G3 box; other site 941639002673 Switch II region; other site 941639002674 G4 box; other site 941639002675 G5 box; other site 941639002676 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 941639002677 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 941639002678 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941639002679 PAS domain S-box; Region: sensory_box; TIGR00229 941639002680 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639002681 putative active site [active] 941639002682 heme pocket [chemical binding]; other site 941639002683 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 941639002684 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639002685 putative active site [active] 941639002686 heme pocket [chemical binding]; other site 941639002687 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639002688 dimer interface [polypeptide binding]; other site 941639002689 phosphorylation site [posttranslational modification] 941639002690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639002691 ATP binding site [chemical binding]; other site 941639002692 Mg2+ binding site [ion binding]; other site 941639002693 G-X-G motif; other site 941639002694 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 941639002695 DNA binding site [nucleotide binding] 941639002696 active site 941639002697 Uncharacterized conserved protein [Function unknown]; Region: COG3339 941639002698 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 941639002699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639002700 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941639002701 Walker A motif; other site 941639002702 ATP binding site [chemical binding]; other site 941639002703 Walker B motif; other site 941639002704 arginine finger; other site 941639002705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639002706 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 941639002707 Walker A motif; other site 941639002708 ATP binding site [chemical binding]; other site 941639002709 Walker B motif; other site 941639002710 arginine finger; other site 941639002711 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 941639002712 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 941639002713 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 941639002714 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 941639002715 dimerization domain swap beta strand [polypeptide binding]; other site 941639002716 regulatory protein interface [polypeptide binding]; other site 941639002717 active site 941639002718 regulatory phosphorylation site [posttranslational modification]; other site 941639002719 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 941639002720 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 941639002721 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941639002722 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941639002723 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941639002724 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 941639002725 putative NAD(P) binding site [chemical binding]; other site 941639002726 putative active site [active] 941639002727 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941639002728 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941639002729 aminotransferase A; Validated; Region: PRK07683 941639002730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639002731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639002732 homodimer interface [polypeptide binding]; other site 941639002733 catalytic residue [active] 941639002734 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 941639002735 Response regulator receiver domain; Region: Response_reg; pfam00072 941639002736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639002737 active site 941639002738 phosphorylation site [posttranslational modification] 941639002739 intermolecular recognition site; other site 941639002740 dimerization interface [polypeptide binding]; other site 941639002741 YkyB-like protein; Region: YkyB; pfam14177 941639002742 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 941639002743 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941639002744 metal binding site [ion binding]; metal-binding site 941639002745 active site 941639002746 I-site; other site 941639002747 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941639002748 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 941639002749 short chain dehydrogenase; Provisional; Region: PRK07677 941639002750 NAD(P) binding site [chemical binding]; other site 941639002751 substrate binding site [chemical binding]; other site 941639002752 homotetramer interface [polypeptide binding]; other site 941639002753 active site 941639002754 homodimer interface [polypeptide binding]; other site 941639002755 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 941639002756 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 941639002757 FOG: CBS domain [General function prediction only]; Region: COG0517 941639002758 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 941639002759 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941639002760 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941639002761 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 941639002762 dimerization interface [polypeptide binding]; other site 941639002763 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 941639002764 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 941639002765 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 941639002766 active site 941639002767 trimer interface [polypeptide binding]; other site 941639002768 substrate binding site [chemical binding]; other site 941639002769 CoA binding site [chemical binding]; other site 941639002770 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941639002771 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941639002772 metal binding site [ion binding]; metal-binding site 941639002773 YhfH-like protein; Region: YhfH; pfam14149 941639002774 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 941639002775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 941639002776 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941639002777 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 941639002778 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 941639002779 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941639002780 TPP-binding site [chemical binding]; other site 941639002781 tetramer interface [polypeptide binding]; other site 941639002782 heterodimer interface [polypeptide binding]; other site 941639002783 phosphorylation loop region [posttranslational modification] 941639002784 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941639002785 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941639002786 alpha subunit interface [polypeptide binding]; other site 941639002787 TPP binding site [chemical binding]; other site 941639002788 heterodimer interface [polypeptide binding]; other site 941639002789 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941639002790 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941639002791 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941639002792 E3 interaction surface; other site 941639002793 lipoyl attachment site [posttranslational modification]; other site 941639002794 e3 binding domain; Region: E3_binding; pfam02817 941639002795 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941639002796 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 941639002797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941639002798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639002799 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941639002800 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 941639002801 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 941639002802 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 941639002803 homodimer interface [polypeptide binding]; other site 941639002804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639002805 catalytic residue [active] 941639002806 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 941639002807 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 941639002808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 941639002809 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 941639002810 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 941639002811 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 941639002812 active site 941639002813 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 941639002814 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 941639002815 G1 box; other site 941639002816 putative GEF interaction site [polypeptide binding]; other site 941639002817 GTP/Mg2+ binding site [chemical binding]; other site 941639002818 Switch I region; other site 941639002819 G2 box; other site 941639002820 G3 box; other site 941639002821 Switch II region; other site 941639002822 G4 box; other site 941639002823 G5 box; other site 941639002824 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 941639002825 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 941639002826 YlaH-like protein; Region: YlaH; pfam14036 941639002827 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 941639002828 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 941639002829 putative active site [active] 941639002830 PhoH-like protein; Region: PhoH; pfam02562 941639002831 hypothetical protein; Provisional; Region: PRK13666 941639002832 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 941639002833 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 941639002834 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 941639002835 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 941639002836 UbiA prenyltransferase family; Region: UbiA; pfam01040 941639002837 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 941639002838 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 941639002839 Cytochrome c; Region: Cytochrom_C; pfam00034 941639002840 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 941639002841 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 941639002842 Putative ubiquinol binding site [chemical binding]; other site 941639002843 Low-spin heme (heme b) binding site [chemical binding]; other site 941639002844 D-pathway; other site 941639002845 Putative water exit pathway; other site 941639002846 Binuclear center (heme o3/CuB) [ion binding]; other site 941639002847 K-pathway; other site 941639002848 Putative proton exit pathway; other site 941639002849 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 941639002850 Subunit I/III interface [polypeptide binding]; other site 941639002851 Subunit III/IV interface [polypeptide binding]; other site 941639002852 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 941639002853 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 941639002854 YugN-like family; Region: YugN; pfam08868 941639002855 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 941639002856 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 941639002857 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941639002858 CoenzymeA binding site [chemical binding]; other site 941639002859 subunit interaction site [polypeptide binding]; other site 941639002860 PHB binding site; other site 941639002861 Putative coat protein; Region: YlbD_coat; pfam14071 941639002862 YlbE-like protein; Region: YlbE; pfam14003 941639002863 Protein of unknown function (DUF964); Region: DUF964; pfam06133 941639002864 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 941639002865 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 941639002866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639002867 S-adenosylmethionine binding site [chemical binding]; other site 941639002868 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 941639002869 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 941639002870 active site 941639002871 (T/H)XGH motif; other site 941639002872 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 941639002873 Nucleoside recognition; Region: Gate; pfam07670 941639002874 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 941639002875 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 941639002876 active site 941639002877 nucleophile elbow; other site 941639002878 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 941639002879 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 941639002880 protein binding site [polypeptide binding]; other site 941639002881 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941639002882 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 941639002883 hypothetical protein; Provisional; Region: PRK13670 941639002884 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 941639002885 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 941639002886 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 941639002887 hypothetical protein; Provisional; Region: PRK13688 941639002888 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 941639002889 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 941639002890 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 941639002891 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 941639002892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 941639002893 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 941639002894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 941639002895 MraZ protein; Region: MraZ; pfam02381 941639002896 MraZ protein; Region: MraZ; pfam02381 941639002897 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 941639002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639002899 S-adenosylmethionine binding site [chemical binding]; other site 941639002900 Cell division protein FtsL; Region: FtsL; cl11433 941639002901 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 941639002902 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941639002903 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941639002904 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 941639002905 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 941639002906 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 941639002907 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941639002908 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941639002909 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 941639002910 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 941639002911 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941639002912 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941639002913 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941639002914 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 941639002915 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 941639002916 Mg++ binding site [ion binding]; other site 941639002917 putative catalytic motif [active] 941639002918 putative substrate binding site [chemical binding]; other site 941639002919 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 941639002920 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941639002921 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941639002922 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 941639002923 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 941639002924 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 941639002925 active site 941639002926 homodimer interface [polypeptide binding]; other site 941639002927 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 941639002928 Cell division protein FtsQ; Region: FtsQ; pfam03799 941639002929 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 941639002930 Cell division protein FtsA; Region: FtsA; pfam14450 941639002931 cell division protein FtsZ; Validated; Region: PRK09330 941639002932 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 941639002933 nucleotide binding site [chemical binding]; other site 941639002934 SulA interaction site; other site 941639002935 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 941639002936 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 941639002937 sporulation sigma factor SigE; Reviewed; Region: PRK08301 941639002938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639002939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639002940 DNA binding residues [nucleotide binding] 941639002941 sporulation sigma factor SigG; Reviewed; Region: PRK08215 941639002942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639002943 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941639002944 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639002945 DNA binding residues [nucleotide binding] 941639002946 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 941639002947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 941639002948 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 941639002949 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 941639002950 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 941639002951 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941639002952 catalytic residue [active] 941639002953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 941639002954 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 941639002955 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639002956 RNA binding surface [nucleotide binding]; other site 941639002957 DivIVA protein; Region: DivIVA; pfam05103 941639002958 DivIVA domain; Region: DivI1A_domain; TIGR03544 941639002959 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 941639002960 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 941639002961 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 941639002962 HIGH motif; other site 941639002963 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941639002964 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 941639002965 active site 941639002966 KMSKS motif; other site 941639002967 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 941639002968 tRNA binding surface [nucleotide binding]; other site 941639002969 anticodon binding site; other site 941639002970 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 941639002971 lipoprotein signal peptidase; Provisional; Region: PRK14787 941639002972 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 941639002973 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 941639002974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639002975 RNA binding surface [nucleotide binding]; other site 941639002976 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 941639002977 active site 941639002978 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 941639002979 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639002980 active site 941639002981 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 941639002982 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941639002983 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941639002984 dihydroorotase; Validated; Region: pyrC; PRK09357 941639002985 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941639002986 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 941639002987 active site 941639002988 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 941639002989 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 941639002990 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 941639002991 catalytic site [active] 941639002992 subunit interface [polypeptide binding]; other site 941639002993 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 941639002994 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941639002995 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941639002996 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 941639002997 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941639002998 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941639002999 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 941639003000 IMP binding site; other site 941639003001 dimer interface [polypeptide binding]; other site 941639003002 interdomain contacts; other site 941639003003 partial ornithine binding site; other site 941639003004 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 941639003005 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 941639003006 FAD binding pocket [chemical binding]; other site 941639003007 FAD binding motif [chemical binding]; other site 941639003008 phosphate binding motif [ion binding]; other site 941639003009 beta-alpha-beta structure motif; other site 941639003010 NAD binding pocket [chemical binding]; other site 941639003011 Iron coordination center [ion binding]; other site 941639003012 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 941639003013 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 941639003014 heterodimer interface [polypeptide binding]; other site 941639003015 active site 941639003016 FMN binding site [chemical binding]; other site 941639003017 homodimer interface [polypeptide binding]; other site 941639003018 substrate binding site [chemical binding]; other site 941639003019 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 941639003020 active site 941639003021 dimer interface [polypeptide binding]; other site 941639003022 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639003023 active site 941639003024 Nuclease-related domain; Region: NERD; pfam08378 941639003025 Helix-turn-helix domain; Region: HTH_18; pfam12833 941639003026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 941639003027 L-rhamnose isomerase; Provisional; Region: PRK01076 941639003028 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 941639003029 active site 941639003030 dimer interfaces [polypeptide binding]; other site 941639003031 catalytic residues [active] 941639003032 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 941639003033 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 941639003034 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 941639003035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639003036 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639003037 putative substrate translocation pore; other site 941639003038 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941639003039 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941639003040 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941639003041 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 941639003042 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 941639003043 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639003044 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941639003045 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 941639003046 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 941639003047 active site 941639003048 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 941639003049 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 941639003050 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 941639003051 Sodium Bile acid symporter family; Region: SBF; pfam01758 941639003052 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 941639003053 Domain of unknown function (DUF814); Region: DUF814; pfam05670 941639003054 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 941639003055 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 941639003056 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941639003057 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 941639003058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639003059 motif II; other site 941639003060 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 941639003061 hypothetical protein; Provisional; Region: PRK11820 941639003062 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 941639003063 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 941639003064 hypothetical protein; Provisional; Region: PRK04323 941639003065 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 941639003066 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 941639003067 catalytic site [active] 941639003068 G-X2-G-X-G-K; other site 941639003069 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 941639003070 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 941639003071 Flavoprotein; Region: Flavoprotein; pfam02441 941639003072 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 941639003073 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 941639003074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639003075 ATP binding site [chemical binding]; other site 941639003076 putative Mg++ binding site [ion binding]; other site 941639003077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639003078 nucleotide binding region [chemical binding]; other site 941639003079 ATP-binding site [chemical binding]; other site 941639003080 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941639003081 active site 941639003082 catalytic residues [active] 941639003083 metal binding site [ion binding]; metal-binding site 941639003084 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 941639003085 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 941639003086 putative active site [active] 941639003087 substrate binding site [chemical binding]; other site 941639003088 putative cosubstrate binding site; other site 941639003089 catalytic site [active] 941639003090 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 941639003091 substrate binding site [chemical binding]; other site 941639003092 16S rRNA methyltransferase B; Provisional; Region: PRK14902 941639003093 NusB family; Region: NusB; pfam01029 941639003094 putative RNA binding site [nucleotide binding]; other site 941639003095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639003096 S-adenosylmethionine binding site [chemical binding]; other site 941639003097 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 941639003098 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 941639003099 Catalytic domain of Protein Kinases; Region: PKc; cd00180 941639003100 active site 941639003101 ATP binding site [chemical binding]; other site 941639003102 substrate binding site [chemical binding]; other site 941639003103 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 941639003104 substrate binding site [chemical binding]; other site 941639003105 activation loop (A-loop); other site 941639003106 activation loop (A-loop); other site 941639003107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 941639003108 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 941639003109 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 941639003110 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 941639003111 GTPase RsgA; Reviewed; Region: PRK00098 941639003112 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 941639003113 RNA binding site [nucleotide binding]; other site 941639003114 homodimer interface [polypeptide binding]; other site 941639003115 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 941639003116 GTPase/Zn-binding domain interface [polypeptide binding]; other site 941639003117 GTP/Mg2+ binding site [chemical binding]; other site 941639003118 G4 box; other site 941639003119 G5 box; other site 941639003120 G1 box; other site 941639003121 Switch I region; other site 941639003122 G2 box; other site 941639003123 G3 box; other site 941639003124 Switch II region; other site 941639003125 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 941639003126 phosphate binding site [ion binding]; other site 941639003127 Thiamine pyrophosphokinase; Region: TPK; cd07995 941639003128 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 941639003129 active site 941639003130 dimerization interface [polypeptide binding]; other site 941639003131 thiamine binding site [chemical binding]; other site 941639003132 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 941639003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 941639003134 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 941639003135 DAK2 domain; Region: Dak2; pfam02734 941639003136 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 941639003137 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 941639003138 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 941639003139 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 941639003140 putative L-serine binding site [chemical binding]; other site 941639003141 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 941639003142 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 941639003143 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941639003144 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639003145 ATP binding site [chemical binding]; other site 941639003146 putative Mg++ binding site [ion binding]; other site 941639003147 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639003148 nucleotide binding region [chemical binding]; other site 941639003149 ATP-binding site [chemical binding]; other site 941639003150 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 941639003151 HGG motif-containing thioesterase, possibly involved in aromatic compounds catabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PaaI; COG2050 941639003152 active site 2 [active] 941639003153 putative phosphate acyltransferase; Provisional; Region: PRK05331 941639003154 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 941639003155 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 941639003156 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 941639003157 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 941639003158 NAD(P) binding site [chemical binding]; other site 941639003159 homotetramer interface [polypeptide binding]; other site 941639003160 homodimer interface [polypeptide binding]; other site 941639003161 active site 941639003162 acyl carrier protein; Provisional; Region: acpP; PRK00982 941639003163 ribonuclease III; Reviewed; Region: rnc; PRK00102 941639003164 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 941639003165 dimerization interface [polypeptide binding]; other site 941639003166 active site 941639003167 metal binding site [ion binding]; metal-binding site 941639003168 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 941639003169 dsRNA binding site [nucleotide binding]; other site 941639003170 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 941639003171 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941639003172 Walker A/P-loop; other site 941639003173 ATP binding site [chemical binding]; other site 941639003174 Q-loop/lid; other site 941639003175 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 941639003176 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 941639003177 ABC transporter signature motif; other site 941639003178 Walker B; other site 941639003179 D-loop; other site 941639003180 H-loop/switch region; other site 941639003181 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 941639003182 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 941639003183 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 941639003184 P loop; other site 941639003185 GTP binding site [chemical binding]; other site 941639003186 putative DNA-binding protein; Validated; Region: PRK00118 941639003187 signal recognition particle protein; Provisional; Region: PRK10867 941639003188 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 941639003189 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 941639003190 P loop; other site 941639003191 GTP binding site [chemical binding]; other site 941639003192 Signal peptide binding domain; Region: SRP_SPB; pfam02978 941639003193 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 941639003194 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 941639003195 KH domain; Region: KH_4; pfam13083 941639003196 G-X-X-G motif; other site 941639003197 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 941639003198 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 941639003199 RimM N-terminal domain; Region: RimM; pfam01782 941639003200 PRC-barrel domain; Region: PRC; pfam05239 941639003201 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 941639003202 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 941639003203 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 941639003204 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941639003205 Catalytic site [active] 941639003206 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 941639003207 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 941639003208 GTP/Mg2+ binding site [chemical binding]; other site 941639003209 G4 box; other site 941639003210 G5 box; other site 941639003211 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 941639003212 G1 box; other site 941639003213 G1 box; other site 941639003214 GTP/Mg2+ binding site [chemical binding]; other site 941639003215 Switch I region; other site 941639003216 G2 box; other site 941639003217 G2 box; other site 941639003218 G3 box; other site 941639003219 G3 box; other site 941639003220 Switch II region; other site 941639003221 Switch II region; other site 941639003222 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 941639003223 RNA/DNA hybrid binding site [nucleotide binding]; other site 941639003224 active site 941639003225 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 941639003226 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 941639003227 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 941639003228 CoA-ligase; Region: Ligase_CoA; pfam00549 941639003229 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 941639003230 CoA binding domain; Region: CoA_binding; pfam02629 941639003231 CoA-ligase; Region: Ligase_CoA; pfam00549 941639003232 DNA protecting protein DprA; Region: dprA; TIGR00732 941639003233 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 941639003234 DNA topoisomerase I; Validated; Region: PRK05582 941639003235 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 941639003236 active site 941639003237 interdomain interaction site; other site 941639003238 putative metal-binding site [ion binding]; other site 941639003239 nucleotide binding site [chemical binding]; other site 941639003240 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941639003241 domain I; other site 941639003242 DNA binding groove [nucleotide binding] 941639003243 phosphate binding site [ion binding]; other site 941639003244 domain II; other site 941639003245 domain III; other site 941639003246 nucleotide binding site [chemical binding]; other site 941639003247 catalytic site [active] 941639003248 domain IV; other site 941639003249 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941639003250 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941639003251 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 941639003252 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 941639003253 active site 941639003254 Int/Topo IB signature motif; other site 941639003255 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 941639003256 active site 941639003257 HslU subunit interaction site [polypeptide binding]; other site 941639003258 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 941639003259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639003260 Walker A motif; other site 941639003261 ATP binding site [chemical binding]; other site 941639003262 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 941639003263 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941639003264 transcriptional repressor CodY; Validated; Region: PRK04158 941639003265 CodY GAF-like domain; Region: CodY; pfam06018 941639003266 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 941639003267 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 941639003268 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941639003269 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 941639003270 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941639003271 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941639003272 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 941639003273 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 941639003274 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 941639003275 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 941639003276 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 941639003277 MgtE intracellular N domain; Region: MgtE_N; smart00924 941639003278 FliG C-terminal domain; Region: FliG_C; pfam01706 941639003279 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 941639003280 Flagellar assembly protein FliH; Region: FliH; pfam02108 941639003281 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 941639003282 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941639003283 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 941639003284 Walker A motif/ATP binding site; other site 941639003285 Walker B motif; other site 941639003286 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 941639003287 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 941639003288 Uncharacterized conserved protein [Function unknown]; Region: COG3334 941639003289 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 941639003290 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 941639003291 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 941639003292 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 941639003293 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 941639003294 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941639003295 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941639003296 Flagellar protein (FlbD); Region: FlbD; cl00683 941639003297 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 941639003298 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 941639003299 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 941639003300 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 941639003301 flagellar motor switch protein; Validated; Region: PRK08119 941639003302 CheC-like family; Region: CheC; pfam04509 941639003303 CheC-like family; Region: CheC; pfam04509 941639003304 flagellar motor switch protein FliN; Region: fliN; TIGR02480 941639003305 Response regulator receiver domain; Region: Response_reg; pfam00072 941639003306 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639003307 active site 941639003308 phosphorylation site [posttranslational modification] 941639003309 intermolecular recognition site; other site 941639003310 dimerization interface [polypeptide binding]; other site 941639003311 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 941639003312 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 941639003313 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 941639003314 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 941639003315 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 941639003316 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 941639003317 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 941639003318 FHIPEP family; Region: FHIPEP; pfam00771 941639003319 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 941639003320 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941639003321 septum site-determining protein MinD; Region: minD_bact; TIGR01968 941639003322 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 941639003323 P-loop; other site 941639003324 CheB methylesterase; Region: CheB_methylest; pfam01339 941639003325 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 941639003326 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 941639003327 putative binding surface; other site 941639003328 active site 941639003329 P2 response regulator binding domain; Region: P2; pfam07194 941639003330 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 941639003331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639003332 ATP binding site [chemical binding]; other site 941639003333 Mg2+ binding site [ion binding]; other site 941639003334 G-X-G motif; other site 941639003335 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 941639003336 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 941639003337 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 941639003338 CheC-like family; Region: CheC; pfam04509 941639003339 CheC-like family; Region: CheC; pfam04509 941639003340 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 941639003341 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 941639003342 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639003343 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639003344 DNA binding residues [nucleotide binding] 941639003345 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 941639003346 rRNA interaction site [nucleotide binding]; other site 941639003347 S8 interaction site; other site 941639003348 putative laminin-1 binding site; other site 941639003349 elongation factor Ts; Provisional; Region: tsf; PRK09377 941639003350 UBA/TS-N domain; Region: UBA; pfam00627 941639003351 Elongation factor TS; Region: EF_TS; pfam00889 941639003352 Elongation factor TS; Region: EF_TS; pfam00889 941639003353 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 941639003354 putative nucleotide binding site [chemical binding]; other site 941639003355 uridine monophosphate binding site [chemical binding]; other site 941639003356 homohexameric interface [polypeptide binding]; other site 941639003357 ribosome recycling factor; Reviewed; Region: frr; PRK00083 941639003358 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 941639003359 hinge region; other site 941639003360 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 941639003361 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 941639003362 catalytic residue [active] 941639003363 putative FPP diphosphate binding site; other site 941639003364 putative FPP binding hydrophobic cleft; other site 941639003365 dimer interface [polypeptide binding]; other site 941639003366 putative IPP diphosphate binding site; other site 941639003367 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 941639003368 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 941639003369 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 941639003370 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 941639003371 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 941639003372 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 941639003373 RIP metalloprotease RseP; Region: TIGR00054 941639003374 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941639003375 active site 941639003376 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 941639003377 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 941639003378 protein binding site [polypeptide binding]; other site 941639003379 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 941639003380 putative substrate binding region [chemical binding]; other site 941639003381 prolyl-tRNA synthetase; Provisional; Region: PRK09194 941639003382 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 941639003383 dimer interface [polypeptide binding]; other site 941639003384 motif 1; other site 941639003385 active site 941639003386 motif 2; other site 941639003387 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 941639003388 putative deacylase active site [active] 941639003389 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 941639003390 active site 941639003391 motif 3; other site 941639003392 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 941639003393 anticodon binding site; other site 941639003394 DNA polymerase III PolC; Validated; Region: polC; PRK00448 941639003395 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 941639003396 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 941639003397 generic binding surface II; other site 941639003398 generic binding surface I; other site 941639003399 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941639003400 active site 941639003401 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941639003402 active site 941639003403 catalytic site [active] 941639003404 substrate binding site [chemical binding]; other site 941639003405 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 941639003406 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 941639003407 ribosome maturation protein RimP; Reviewed; Region: PRK00092 941639003408 Sm and related proteins; Region: Sm_like; cl00259 941639003409 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 941639003410 putative oligomer interface [polypeptide binding]; other site 941639003411 putative RNA binding site [nucleotide binding]; other site 941639003412 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 941639003413 NusA N-terminal domain; Region: NusA_N; pfam08529 941639003414 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 941639003415 RNA binding site [nucleotide binding]; other site 941639003416 homodimer interface [polypeptide binding]; other site 941639003417 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 941639003418 G-X-X-G motif; other site 941639003419 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 941639003420 G-X-X-G motif; other site 941639003421 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 941639003422 putative RNA binding cleft [nucleotide binding]; other site 941639003423 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 941639003424 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 941639003425 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 941639003426 G1 box; other site 941639003427 putative GEF interaction site [polypeptide binding]; other site 941639003428 GTP/Mg2+ binding site [chemical binding]; other site 941639003429 Switch I region; other site 941639003430 G2 box; other site 941639003431 G3 box; other site 941639003432 Switch II region; other site 941639003433 G4 box; other site 941639003434 G5 box; other site 941639003435 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 941639003436 Translation-initiation factor 2; Region: IF-2; pfam11987 941639003437 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 941639003438 Protein of unknown function (DUF503); Region: DUF503; cl00669 941639003439 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 941639003440 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 941639003441 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 941639003442 RNA binding site [nucleotide binding]; other site 941639003443 active site 941639003444 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 941639003445 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 941639003446 Riboflavin kinase; Region: Flavokinase; pfam01687 941639003447 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 941639003448 16S/18S rRNA binding site [nucleotide binding]; other site 941639003449 S13e-L30e interaction site [polypeptide binding]; other site 941639003450 25S rRNA binding site [nucleotide binding]; other site 941639003451 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 941639003452 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 941639003453 RNase E interface [polypeptide binding]; other site 941639003454 trimer interface [polypeptide binding]; other site 941639003455 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 941639003456 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 941639003457 RNase E interface [polypeptide binding]; other site 941639003458 trimer interface [polypeptide binding]; other site 941639003459 active site 941639003460 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 941639003461 putative nucleic acid binding region [nucleotide binding]; other site 941639003462 G-X-X-G motif; other site 941639003463 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 941639003464 RNA binding site [nucleotide binding]; other site 941639003465 domain interface; other site 941639003466 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 941639003467 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 941639003468 NodB motif; other site 941639003469 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941639003470 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941639003471 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941639003472 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 941639003473 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 941639003474 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 941639003475 NAD binding site [chemical binding]; other site 941639003476 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 941639003477 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 941639003478 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941639003479 aspartate kinase I; Reviewed; Region: PRK08210 941639003480 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 941639003481 nucleotide binding site [chemical binding]; other site 941639003482 substrate binding site [chemical binding]; other site 941639003483 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 941639003484 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 941639003485 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 941639003486 dihydrodipicolinate synthase; Region: dapA; TIGR00674 941639003487 dimer interface [polypeptide binding]; other site 941639003488 active site 941639003489 catalytic residue [active] 941639003490 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 941639003491 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 941639003492 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 941639003493 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 941639003494 Clp protease; Region: CLP_protease; pfam00574 941639003495 active site 941639003496 YlzJ-like protein; Region: YlzJ; pfam14035 941639003497 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 941639003498 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941639003499 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 941639003500 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 941639003501 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 941639003502 ligand binding site [chemical binding]; other site 941639003503 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 941639003504 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941639003505 Walker A/P-loop; other site 941639003506 ATP binding site [chemical binding]; other site 941639003507 Q-loop/lid; other site 941639003508 ABC transporter signature motif; other site 941639003509 Walker B; other site 941639003510 D-loop; other site 941639003511 H-loop/switch region; other site 941639003512 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941639003513 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941639003514 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941639003515 TM-ABC transporter signature motif; other site 941639003516 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 941639003517 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941639003518 TM-ABC transporter signature motif; other site 941639003519 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941639003520 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941639003521 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 941639003522 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 941639003523 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 941639003524 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941639003525 classical (c) SDRs; Region: SDR_c; cd05233 941639003526 NAD(P) binding site [chemical binding]; other site 941639003527 active site 941639003528 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 941639003529 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 941639003530 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 941639003531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639003532 non-specific DNA binding site [nucleotide binding]; other site 941639003533 salt bridge; other site 941639003534 sequence-specific DNA binding site [nucleotide binding]; other site 941639003535 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 941639003536 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 941639003537 competence damage-inducible protein A; Provisional; Region: PRK00549 941639003538 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 941639003539 putative MPT binding site; other site 941639003540 Competence-damaged protein; Region: CinA; pfam02464 941639003541 recombinase A; Provisional; Region: recA; PRK09354 941639003542 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 941639003543 hexamer interface [polypeptide binding]; other site 941639003544 Walker A motif; other site 941639003545 ATP binding site [chemical binding]; other site 941639003546 Walker B motif; other site 941639003547 phosphodiesterase; Provisional; Region: PRK12704 941639003548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639003549 Zn2+ binding site [ion binding]; other site 941639003550 Mg2+ binding site [ion binding]; other site 941639003551 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 941639003552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941639003553 putative active site [active] 941639003554 metal binding site [ion binding]; metal-binding site 941639003555 homodimer binding site [polypeptide binding]; other site 941639003556 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 941639003557 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941639003558 Peptidase family U32; Region: Peptidase_U32; pfam01136 941639003559 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 941639003560 Peptidase family U32; Region: Peptidase_U32; pfam01136 941639003561 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 941639003562 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 941639003563 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 941639003564 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941639003565 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639003566 FeS/SAM binding site; other site 941639003567 TRAM domain; Region: TRAM; pfam01938 941639003568 Predicted membrane protein [Function unknown]; Region: COG4550 941639003569 Outer spore coat protein E (CotE); Region: CotE; pfam10628 941639003570 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 941639003571 MutS domain I; Region: MutS_I; pfam01624 941639003572 MutS domain II; Region: MutS_II; pfam05188 941639003573 MutS domain III; Region: MutS_III; pfam05192 941639003574 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 941639003575 Walker A/P-loop; other site 941639003576 ATP binding site [chemical binding]; other site 941639003577 Q-loop/lid; other site 941639003578 ABC transporter signature motif; other site 941639003579 Walker B; other site 941639003580 D-loop; other site 941639003581 H-loop/switch region; other site 941639003582 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 941639003583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639003584 ATP binding site [chemical binding]; other site 941639003585 Mg2+ binding site [ion binding]; other site 941639003586 G-X-G motif; other site 941639003587 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 941639003588 ATP binding site [chemical binding]; other site 941639003589 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 941639003590 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 941639003591 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 941639003592 IPP transferase; Region: IPPT; pfam01715 941639003593 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 941639003594 bacterial Hfq-like; Region: Hfq; cd01716 941639003595 hexamer interface [polypeptide binding]; other site 941639003596 Sm1 motif; other site 941639003597 RNA binding site [nucleotide binding]; other site 941639003598 Sm2 motif; other site 941639003599 stage V sporulation protein K; Region: spore_V_K; TIGR02881 941639003600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639003601 Walker A motif; other site 941639003602 ATP binding site [chemical binding]; other site 941639003603 Walker B motif; other site 941639003604 arginine finger; other site 941639003605 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 941639003606 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 941639003607 HflX GTPase family; Region: HflX; cd01878 941639003608 G1 box; other site 941639003609 GTP/Mg2+ binding site [chemical binding]; other site 941639003610 Switch I region; other site 941639003611 G2 box; other site 941639003612 G3 box; other site 941639003613 Switch II region; other site 941639003614 G4 box; other site 941639003615 G5 box; other site 941639003616 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 941639003617 Aluminium resistance protein; Region: Alum_res; pfam06838 941639003618 5'-3' exonuclease; Region: 53EXOc; smart00475 941639003619 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 941639003620 active site 941639003621 metal binding site 1 [ion binding]; metal-binding site 941639003622 putative 5' ssDNA interaction site; other site 941639003623 metal binding site 3; metal-binding site 941639003624 metal binding site 2 [ion binding]; metal-binding site 941639003625 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 941639003626 putative DNA binding site [nucleotide binding]; other site 941639003627 putative metal binding site [ion binding]; other site 941639003628 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 941639003629 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 941639003630 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941639003631 DNA-binding site [nucleotide binding]; DNA binding site 941639003632 RNA-binding motif; other site 941639003633 manganese transport transcriptional regulator; Provisional; Region: PRK03902 941639003634 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 941639003635 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 941639003636 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 941639003637 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 941639003638 Potassium binding sites [ion binding]; other site 941639003639 Cesium cation binding sites [ion binding]; other site 941639003640 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941639003641 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639003642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639003643 ABC transporter; Region: ABC_tran_2; pfam12848 941639003644 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639003645 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 941639003646 Virulence factor; Region: Virulence_fact; pfam13769 941639003647 HEAT repeat; Region: HEAT; pfam02985 941639003648 HEAT repeats; Region: HEAT_2; pfam13646 941639003649 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 941639003650 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 941639003651 YpjP-like protein; Region: YpjP; pfam14005 941639003652 thymidylate synthase; Reviewed; Region: thyA; PRK01827 941639003653 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 941639003654 dimerization interface [polypeptide binding]; other site 941639003655 active site 941639003656 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 941639003657 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 941639003658 folate binding site [chemical binding]; other site 941639003659 NADP+ binding site [chemical binding]; other site 941639003660 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 941639003661 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 941639003662 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 941639003663 active site 941639003664 catalytic triad [active] 941639003665 oxyanion hole [active] 941639003666 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 941639003667 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 941639003668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639003669 S-adenosylmethionine binding site [chemical binding]; other site 941639003670 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 941639003671 SelR domain; Region: SelR; pfam01641 941639003672 methionine sulfoxide reductase B; Provisional; Region: PRK00222 941639003673 CHASE3 domain; Region: CHASE3; pfam05227 941639003674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 941639003675 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639003676 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639003677 dimer interface [polypeptide binding]; other site 941639003678 putative CheW interface [polypeptide binding]; other site 941639003679 YozD-like protein; Region: YozD; pfam14162 941639003680 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 941639003681 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 941639003682 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 941639003683 C-terminal peptidase (prc); Region: prc; TIGR00225 941639003684 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 941639003685 protein binding site [polypeptide binding]; other site 941639003686 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 941639003687 Catalytic dyad [active] 941639003688 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941639003689 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941639003690 MarR family; Region: MarR_2; cl17246 941639003691 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 941639003692 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 941639003693 multidrug efflux protein; Reviewed; Region: PRK01766 941639003694 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 941639003695 cation binding site [ion binding]; other site 941639003696 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 941639003697 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 941639003698 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 941639003699 active site 941639003700 DNA binding site [nucleotide binding] 941639003701 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 941639003702 nucleotide binding site [chemical binding]; other site 941639003703 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 941639003704 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 941639003705 putative homodimer interface [polypeptide binding]; other site 941639003706 putative DNA binding site [nucleotide binding]; other site 941639003707 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 941639003708 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941639003709 active site 941639003710 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 941639003711 Sulfatase; Region: Sulfatase; pfam00884 941639003712 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 941639003713 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 941639003714 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 941639003715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639003716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639003717 putative substrate translocation pore; other site 941639003718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639003719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639003720 active site 941639003721 phosphorylation site [posttranslational modification] 941639003722 intermolecular recognition site; other site 941639003723 dimerization interface [polypeptide binding]; other site 941639003724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639003725 DNA binding site [nucleotide binding] 941639003726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941639003727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639003728 dimerization interface [polypeptide binding]; other site 941639003729 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639003730 dimer interface [polypeptide binding]; other site 941639003731 phosphorylation site [posttranslational modification] 941639003732 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639003733 ATP binding site [chemical binding]; other site 941639003734 Mg2+ binding site [ion binding]; other site 941639003735 G-X-G motif; other site 941639003736 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 941639003737 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 941639003738 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 941639003739 TPP-binding site [chemical binding]; other site 941639003740 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 941639003741 dimer interface [polypeptide binding]; other site 941639003742 PYR/PP interface [polypeptide binding]; other site 941639003743 TPP binding site [chemical binding]; other site 941639003744 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 941639003745 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941639003746 E3 interaction surface; other site 941639003747 lipoyl attachment site [posttranslational modification]; other site 941639003748 e3 binding domain; Region: E3_binding; pfam02817 941639003749 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941639003750 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 941639003751 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941639003752 NAD(P) binding site [chemical binding]; other site 941639003753 catalytic residues [active] 941639003754 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 941639003755 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941639003756 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941639003757 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941639003758 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941639003759 DNA topoisomerase III; Provisional; Region: PRK07726 941639003760 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 941639003761 active site 941639003762 putative interdomain interaction site [polypeptide binding]; other site 941639003763 putative metal-binding site [ion binding]; other site 941639003764 putative nucleotide binding site [chemical binding]; other site 941639003765 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941639003766 domain I; other site 941639003767 DNA binding groove [nucleotide binding] 941639003768 phosphate binding site [ion binding]; other site 941639003769 domain II; other site 941639003770 domain III; other site 941639003771 nucleotide binding site [chemical binding]; other site 941639003772 catalytic site [active] 941639003773 domain IV; other site 941639003774 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941639003775 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 941639003776 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 941639003777 active site residue [active] 941639003778 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 941639003779 Uncharacterized conserved protein [Function unknown]; Region: COG2135 941639003780 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 941639003781 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941639003782 FOG: CBS domain [General function prediction only]; Region: COG0517 941639003783 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941639003784 FAD dependent oxidoreductase; Region: DAO; pfam01266 941639003785 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 941639003786 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 941639003787 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 941639003788 [2Fe-2S] cluster binding site [ion binding]; other site 941639003789 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639003790 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639003791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 941639003792 DNA topoisomerase III; Provisional; Region: PRK07726 941639003793 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 941639003794 active site 941639003795 putative interdomain interaction site [polypeptide binding]; other site 941639003796 putative metal-binding site [ion binding]; other site 941639003797 putative nucleotide binding site [chemical binding]; other site 941639003798 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 941639003799 domain I; other site 941639003800 DNA binding groove [nucleotide binding] 941639003801 phosphate binding site [ion binding]; other site 941639003802 domain II; other site 941639003803 domain III; other site 941639003804 nucleotide binding site [chemical binding]; other site 941639003805 catalytic site [active] 941639003806 domain IV; other site 941639003807 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 941639003808 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 941639003809 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 941639003810 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 941639003811 oligomer interface [polypeptide binding]; other site 941639003812 Cl binding site [ion binding]; other site 941639003813 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941639003814 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 941639003815 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941639003816 dimer interface [polypeptide binding]; other site 941639003817 motif 1; other site 941639003818 active site 941639003819 motif 2; other site 941639003820 motif 3; other site 941639003821 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 941639003822 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 941639003823 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 941639003824 histidinol dehydrogenase; Region: hisD; TIGR00069 941639003825 NAD binding site [chemical binding]; other site 941639003826 dimerization interface [polypeptide binding]; other site 941639003827 product binding site; other site 941639003828 substrate binding site [chemical binding]; other site 941639003829 zinc binding site [ion binding]; other site 941639003830 catalytic residues [active] 941639003831 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 941639003832 putative active site pocket [active] 941639003833 4-fold oligomerization interface [polypeptide binding]; other site 941639003834 metal binding residues [ion binding]; metal-binding site 941639003835 3-fold/trimer interface [polypeptide binding]; other site 941639003836 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 941639003837 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 941639003838 putative active site [active] 941639003839 oxyanion strand; other site 941639003840 catalytic triad [active] 941639003841 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 941639003842 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 941639003843 catalytic residues [active] 941639003844 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 941639003845 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 941639003846 substrate binding site [chemical binding]; other site 941639003847 glutamase interaction surface [polypeptide binding]; other site 941639003848 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 941639003849 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; pfam01502 941639003850 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 941639003851 metal binding site [ion binding]; metal-binding site 941639003852 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941639003853 CPxP motif; other site 941639003854 putative inner membrane protein; Provisional; Region: PRK11099 941639003855 rarD protein; Region: rarD; TIGR00688 941639003856 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 941639003857 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 941639003858 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 941639003859 TrkA-N domain; Region: TrkA_N; pfam02254 941639003860 TrkA-C domain; Region: TrkA_C; pfam02080 941639003861 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 941639003862 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 941639003863 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 941639003864 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639003865 putative substrate translocation pore; other site 941639003866 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 941639003867 ABC1 family; Region: ABC1; pfam03109 941639003868 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941639003869 active site 941639003870 ATP binding site [chemical binding]; other site 941639003871 Uncharacterized conserved protein [Function unknown]; Region: COG3937 941639003872 methionine sulfoxide reductase A; Provisional; Region: PRK14054 941639003873 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941639003874 DNA-binding site [nucleotide binding]; DNA binding site 941639003875 RNA-binding motif; other site 941639003876 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 941639003877 GTP cyclohydrolase I; Provisional; Region: PLN03044 941639003878 active site 941639003879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 941639003880 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639003881 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639003882 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 941639003883 FtsX-like permease family; Region: FtsX; pfam02687 941639003884 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 941639003885 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 941639003886 Walker A/P-loop; other site 941639003887 ATP binding site [chemical binding]; other site 941639003888 Q-loop/lid; other site 941639003889 ABC transporter signature motif; other site 941639003890 Walker B; other site 941639003891 D-loop; other site 941639003892 H-loop/switch region; other site 941639003893 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941639003894 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 941639003895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639003896 ATP binding site [chemical binding]; other site 941639003897 Mg2+ binding site [ion binding]; other site 941639003898 G-X-G motif; other site 941639003899 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639003900 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639003901 active site 941639003902 phosphorylation site [posttranslational modification] 941639003903 intermolecular recognition site; other site 941639003904 dimerization interface [polypeptide binding]; other site 941639003905 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639003906 DNA binding site [nucleotide binding] 941639003907 potential frameshift: common BLAST hit: gi|321313565|ref|YP_004205852.1| putative exopolysaccharide pyruvyl transferase 941639003908 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 941639003909 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 941639003910 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 941639003911 putative transport protein YifK; Provisional; Region: PRK10746 941639003912 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 941639003913 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 941639003914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 941639003915 Transposase; Region: DDE_Tnp_ISL3; pfam01610 941639003916 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639003917 metal-binding site [ion binding] 941639003918 mercuric reductase; Region: MerA; TIGR02053 941639003919 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639003920 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941639003921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 941639003922 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941639003923 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 941639003924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639003925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639003926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639003927 Walker A/P-loop; other site 941639003928 ATP binding site [chemical binding]; other site 941639003929 Q-loop/lid; other site 941639003930 ABC transporter signature motif; other site 941639003931 Walker B; other site 941639003932 D-loop; other site 941639003933 H-loop/switch region; other site 941639003934 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639003935 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639003936 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 941639003937 Walker A/P-loop; other site 941639003938 ATP binding site [chemical binding]; other site 941639003939 Q-loop/lid; other site 941639003940 ABC transporter signature motif; other site 941639003941 Walker B; other site 941639003942 D-loop; other site 941639003943 H-loop/switch region; other site 941639003944 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941639003945 LrgA family; Region: LrgA; cl00608 941639003946 LrgB-like family; Region: LrgB; pfam04172 941639003947 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 941639003948 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 941639003949 dimer interface [polypeptide binding]; other site 941639003950 acyl-activating enzyme (AAE) consensus motif; other site 941639003951 putative active site [active] 941639003952 AMP binding site [chemical binding]; other site 941639003953 putative CoA binding site [chemical binding]; other site 941639003954 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 941639003955 N-acetyl-D-glucosamine binding site [chemical binding]; other site 941639003956 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 941639003957 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 941639003958 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 941639003959 putative active site [active] 941639003960 putative NTP binding site [chemical binding]; other site 941639003961 putative nucleic acid binding site [nucleotide binding]; other site 941639003962 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 941639003963 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 941639003964 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 941639003965 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 941639003966 aconitate hydratase; Validated; Region: PRK09277 941639003967 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 941639003968 substrate binding site [chemical binding]; other site 941639003969 ligand binding site [chemical binding]; other site 941639003970 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 941639003971 substrate binding site [chemical binding]; other site 941639003972 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 941639003973 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 941639003974 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 941639003975 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941639003976 active site 941639003977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 941639003978 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 941639003979 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 941639003980 TopoisomeraseII; Region: TOP2c; smart00433 941639003981 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 941639003982 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 941639003983 anchoring element; other site 941639003984 dimer interface [polypeptide binding]; other site 941639003985 ATP binding site [chemical binding]; other site 941639003986 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 941639003987 active site 941639003988 putative metal-binding site [ion binding]; other site 941639003989 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 941639003990 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 941639003991 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 941639003992 CAP-like domain; other site 941639003993 active site 941639003994 primary dimer interface [polypeptide binding]; other site 941639003995 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639003996 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639003997 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 941639003998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639003999 putative substrate translocation pore; other site 941639004000 PEP synthetase regulatory protein; Provisional; Region: PRK05339 941639004001 pyruvate phosphate dikinase; Provisional; Region: PRK09279 941639004002 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 941639004003 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 941639004004 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 941639004005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941639004006 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 941639004007 dimer interface [polypeptide binding]; other site 941639004008 putative metal binding site [ion binding]; other site 941639004009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 941639004010 Nitronate monooxygenase; Region: NMO; pfam03060 941639004011 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 941639004012 FMN binding site [chemical binding]; other site 941639004013 substrate binding site [chemical binding]; other site 941639004014 putative catalytic residue [active] 941639004015 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 941639004016 Signal peptidase, peptidase S26; Region: Peptidase_S26; pfam10502 941639004017 Catalytic site [active] 941639004018 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 941639004019 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 941639004020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639004021 Coenzyme A binding pocket [chemical binding]; other site 941639004022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 941639004023 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639004024 Coenzyme A binding pocket [chemical binding]; other site 941639004025 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 941639004026 Na binding site [ion binding]; other site 941639004027 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 941639004028 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941639004029 dimer interface [polypeptide binding]; other site 941639004030 substrate binding site [chemical binding]; other site 941639004031 ATP binding site [chemical binding]; other site 941639004032 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 941639004033 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 941639004034 putative NAD(P) binding site [chemical binding]; other site 941639004035 active site 941639004036 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 941639004037 substrate binding site [chemical binding]; other site 941639004038 multimerization interface [polypeptide binding]; other site 941639004039 ATP binding site [chemical binding]; other site 941639004040 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941639004041 dimer interface [polypeptide binding]; other site 941639004042 substrate binding site [chemical binding]; other site 941639004043 ATP binding site [chemical binding]; other site 941639004044 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 941639004045 thiamine phosphate binding site [chemical binding]; other site 941639004046 active site 941639004047 pyrophosphate binding site [ion binding]; other site 941639004048 YkyB-like protein; Region: YkyB; pfam14177 941639004049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 941639004050 MOSC domain; Region: MOSC; pfam03473 941639004051 3-alpha domain; Region: 3-alpha; pfam03475 941639004052 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 941639004053 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 941639004054 putative active site [active] 941639004055 putative NTP binding site [chemical binding]; other site 941639004056 putative nucleic acid binding site [nucleotide binding]; other site 941639004057 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 941639004058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639004059 Coenzyme A binding pocket [chemical binding]; other site 941639004060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941639004061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941639004062 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639004063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639004064 putative substrate translocation pore; other site 941639004065 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941639004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639004067 dimer interface [polypeptide binding]; other site 941639004068 conserved gate region; other site 941639004069 putative PBP binding loops; other site 941639004070 ABC-ATPase subunit interface; other site 941639004071 NMT1/THI5 like; Region: NMT1; pfam09084 941639004072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 941639004073 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941639004074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 941639004075 active site 941639004076 metal binding site [ion binding]; metal-binding site 941639004077 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 941639004078 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 941639004079 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 941639004080 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 941639004081 Flavodoxin; Region: Flavodoxin_1; pfam00258 941639004082 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 941639004083 FAD binding pocket [chemical binding]; other site 941639004084 FAD binding motif [chemical binding]; other site 941639004085 catalytic residues [active] 941639004086 NAD binding pocket [chemical binding]; other site 941639004087 phosphate binding motif [ion binding]; other site 941639004088 beta-alpha-beta structure motif; other site 941639004089 sulfite reductase subunit beta; Provisional; Region: PRK13504 941639004090 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941639004091 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 941639004092 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 941639004093 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941639004094 DNA binding residues [nucleotide binding] 941639004095 dimer interface [polypeptide binding]; other site 941639004096 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 941639004097 hypothetical protein; Provisional; Region: PRK08201 941639004098 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 941639004099 metal binding site [ion binding]; metal-binding site 941639004100 putative dimer interface [polypeptide binding]; other site 941639004101 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 941639004102 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941639004103 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941639004104 tetramer interface [polypeptide binding]; other site 941639004105 TPP-binding site [chemical binding]; other site 941639004106 heterodimer interface [polypeptide binding]; other site 941639004107 phosphorylation loop region [posttranslational modification] 941639004108 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941639004109 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941639004110 alpha subunit interface [polypeptide binding]; other site 941639004111 TPP binding site [chemical binding]; other site 941639004112 heterodimer interface [polypeptide binding]; other site 941639004113 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941639004114 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941639004115 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941639004116 E3 interaction surface; other site 941639004117 lipoyl attachment site [posttranslational modification]; other site 941639004118 e3 binding domain; Region: E3_binding; pfam02817 941639004119 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941639004120 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 941639004121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639004122 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941639004123 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 941639004124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639004125 Walker A motif; other site 941639004126 ATP binding site [chemical binding]; other site 941639004127 Walker B motif; other site 941639004128 arginine finger; other site 941639004129 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941639004130 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941639004131 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941639004132 SCP-2 sterol transfer family; Region: SCP2; pfam02036 941639004133 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 941639004134 putative ADP-ribose binding site [chemical binding]; other site 941639004135 putative active site [active] 941639004136 Small acid-soluble spore protein H family; Region: SspH; pfam08141 941639004137 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 941639004138 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 941639004139 NAD binding site [chemical binding]; other site 941639004140 homodimer interface [polypeptide binding]; other site 941639004141 homotetramer interface [polypeptide binding]; other site 941639004142 active site 941639004143 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 941639004144 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941639004145 dimer interface [polypeptide binding]; other site 941639004146 active site 941639004147 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 941639004148 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 941639004149 acyl-activating enzyme (AAE) consensus motif; other site 941639004150 AMP binding site [chemical binding]; other site 941639004151 active site 941639004152 CoA binding site [chemical binding]; other site 941639004153 Replication terminator protein; Region: RTP; pfam02334 941639004154 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941639004155 Predicted membrane protein [Function unknown]; Region: COG2322 941639004156 YceG-like family; Region: YceG; pfam02618 941639004157 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 941639004158 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 941639004159 NAD binding site [chemical binding]; other site 941639004160 dimer interface [polypeptide binding]; other site 941639004161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941639004162 substrate binding site [chemical binding]; other site 941639004163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639004164 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639004165 putative substrate translocation pore; other site 941639004166 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941639004167 classical (c) SDRs; Region: SDR_c; cd05233 941639004168 NAD(P) binding site [chemical binding]; other site 941639004169 active site 941639004170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639004171 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639004172 putative substrate translocation pore; other site 941639004173 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 941639004174 active site 941639004175 putative catalytic site [active] 941639004176 DNA binding site [nucleotide binding] 941639004177 putative phosphate binding site [ion binding]; other site 941639004178 metal binding site A [ion binding]; metal-binding site 941639004179 AP binding site [nucleotide binding]; other site 941639004180 metal binding site B [ion binding]; metal-binding site 941639004181 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 941639004182 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941639004183 glycogen synthase; Provisional; Region: glgA; PRK00654 941639004184 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 941639004185 ADP-binding pocket [chemical binding]; other site 941639004186 homodimer interface [polypeptide binding]; other site 941639004187 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 941639004188 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 941639004189 ligand binding site; other site 941639004190 oligomer interface; other site 941639004191 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 941639004192 dimer interface [polypeptide binding]; other site 941639004193 N-terminal domain interface [polypeptide binding]; other site 941639004194 sulfate 1 binding site; other site 941639004195 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 941639004196 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 941639004197 ligand binding site; other site 941639004198 oligomer interface; other site 941639004199 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 941639004200 dimer interface [polypeptide binding]; other site 941639004201 N-terminal domain interface [polypeptide binding]; other site 941639004202 sulfate 1 binding site; other site 941639004203 glycogen branching enzyme; Provisional; Region: PRK12313 941639004204 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 941639004205 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 941639004206 active site 941639004207 catalytic site [active] 941639004208 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 941639004209 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 941639004210 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 941639004211 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 941639004212 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 941639004213 putative active site [active] 941639004214 putative CoA binding site [chemical binding]; other site 941639004215 nudix motif; other site 941639004216 metal binding site [ion binding]; metal-binding site 941639004217 manganese transport protein MntH; Reviewed; Region: PRK00701 941639004218 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 941639004219 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 941639004220 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 941639004221 dimerization interface [polypeptide binding]; other site 941639004222 DPS ferroxidase diiron center [ion binding]; other site 941639004223 ion pore; other site 941639004224 VanZ like family; Region: VanZ; pfam04892 941639004225 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941639004226 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 941639004227 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941639004228 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639004229 Walker A/P-loop; other site 941639004230 ATP binding site [chemical binding]; other site 941639004231 Q-loop/lid; other site 941639004232 ABC transporter signature motif; other site 941639004233 Walker B; other site 941639004234 D-loop; other site 941639004235 H-loop/switch region; other site 941639004236 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 941639004237 FAD binding domain; Region: FAD_binding_4; pfam01565 941639004238 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 941639004239 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 941639004240 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 941639004241 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 941639004242 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 941639004243 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 941639004244 active site 2 [active] 941639004245 active site 1 [active] 941639004246 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 941639004247 active site 941639004248 catalytic site [active] 941639004249 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941639004250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639004251 NAD(P) binding site [chemical binding]; other site 941639004252 active site 941639004253 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 941639004254 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 941639004255 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 941639004256 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 941639004257 active site residue [active] 941639004258 selenophosphate synthetase; Provisional; Region: PRK00943 941639004259 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 941639004260 dimerization interface [polypeptide binding]; other site 941639004261 putative ATP binding site [chemical binding]; other site 941639004262 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 941639004263 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941639004264 active site 941639004265 metal binding site [ion binding]; metal-binding site 941639004266 Predicted permease; Region: DUF318; cl17795 941639004267 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 941639004268 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 941639004269 putative catalytic cysteine [active] 941639004270 gamma-glutamyl kinase; Provisional; Region: PRK05429 941639004271 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 941639004272 nucleotide binding site [chemical binding]; other site 941639004273 homotetrameric interface [polypeptide binding]; other site 941639004274 putative phosphate binding site [ion binding]; other site 941639004275 putative allosteric binding site; other site 941639004276 PUA domain; Region: PUA; pfam01472 941639004277 Uncharacterized conserved protein [Function unknown]; Region: COG2427 941639004278 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 941639004279 DHH family; Region: DHH; pfam01368 941639004280 DHHA1 domain; Region: DHHA1; pfam02272 941639004281 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 941639004282 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941639004283 active site 941639004284 dimer interface [polypeptide binding]; other site 941639004285 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 941639004286 putative active site [active] 941639004287 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 941639004288 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941639004289 DNA binding residues [nucleotide binding] 941639004290 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 941639004291 active site 941639004292 catalytic residues [active] 941639004293 metal binding site [ion binding]; metal-binding site 941639004294 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 941639004295 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941639004296 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 941639004297 G3 box; other site 941639004298 Switch II region; other site 941639004299 GTP/Mg2+ binding site [chemical binding]; other site 941639004300 G4 box; other site 941639004301 G5 box; other site 941639004302 Nucleoside recognition; Region: Gate; pfam07670 941639004303 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 941639004304 Nucleoside recognition; Region: Gate; pfam07670 941639004305 FeoA domain; Region: FeoA; pfam04023 941639004306 aspartate aminotransferase; Provisional; Region: PRK07681 941639004307 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639004308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639004309 homodimer interface [polypeptide binding]; other site 941639004310 catalytic residue [active] 941639004311 argininosuccinate lyase; Provisional; Region: PRK00855 941639004312 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 941639004313 active sites [active] 941639004314 tetramer interface [polypeptide binding]; other site 941639004315 argininosuccinate synthase; Provisional; Region: PRK13820 941639004316 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 941639004317 ANP binding site [chemical binding]; other site 941639004318 Substrate Binding Site II [chemical binding]; other site 941639004319 Substrate Binding Site I [chemical binding]; other site 941639004320 ornithine carbamoyltransferase; Provisional; Region: PRK00779 941639004321 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 941639004322 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 941639004323 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 941639004324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941639004325 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 941639004326 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 941639004327 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941639004328 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941639004329 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 941639004330 substrate binding site [chemical binding]; other site 941639004331 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 941639004332 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 941639004333 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 941639004334 catalytic site [active] 941639004335 subunit interface [polypeptide binding]; other site 941639004336 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941639004337 acetylornithine aminotransferase; Provisional; Region: PRK02627 941639004338 inhibitor-cofactor binding pocket; inhibition site 941639004339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639004340 catalytic residue [active] 941639004341 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 941639004342 nucleotide binding site [chemical binding]; other site 941639004343 N-acetyl-L-glutamate binding site [chemical binding]; other site 941639004344 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 941639004345 heterotetramer interface [polypeptide binding]; other site 941639004346 active site pocket [active] 941639004347 cleavage site 941639004348 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 941639004349 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 941639004350 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 941639004351 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 941639004352 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 941639004353 DNA-binding site [nucleotide binding]; DNA binding site 941639004354 RNA-binding motif; other site 941639004355 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 941639004356 dimer interface [polypeptide binding]; other site 941639004357 catalytic triad [active] 941639004358 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 941639004359 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 941639004360 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 941639004361 putative acyl-acceptor binding pocket; other site 941639004362 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 941639004363 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 941639004364 Response regulator receiver domain; Region: Response_reg; pfam00072 941639004365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639004366 active site 941639004367 phosphorylation site [posttranslational modification] 941639004368 intermolecular recognition site; other site 941639004369 dimerization interface [polypeptide binding]; other site 941639004370 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 941639004371 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 941639004372 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 941639004373 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 941639004374 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 941639004375 TPP-binding site [chemical binding]; other site 941639004376 dimer interface [polypeptide binding]; other site 941639004377 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941639004378 PYR/PP interface [polypeptide binding]; other site 941639004379 dimer interface [polypeptide binding]; other site 941639004380 TPP binding site [chemical binding]; other site 941639004381 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 941639004382 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 941639004383 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 941639004384 catalytic residues [active] 941639004385 catalytic nucleophile [active] 941639004386 cell division suppressor protein YneA; Provisional; Region: PRK14125 941639004387 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 941639004388 Catalytic site [active] 941639004389 glutamine synthetase, type I; Region: GlnA; TIGR00653 941639004390 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 941639004391 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 941639004392 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 941639004393 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 941639004394 putative dimer interface [polypeptide binding]; other site 941639004395 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 941639004396 Dynamin family; Region: Dynamin_N; pfam00350 941639004397 G1 box; other site 941639004398 GTP/Mg2+ binding site [chemical binding]; other site 941639004399 G2 box; other site 941639004400 Switch I region; other site 941639004401 G3 box; other site 941639004402 Switch II region; other site 941639004403 G4 box; other site 941639004404 G5 box; other site 941639004405 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941639004406 Dynamin family; Region: Dynamin_N; pfam00350 941639004407 G1 box; other site 941639004408 GTP/Mg2+ binding site [chemical binding]; other site 941639004409 G2 box; other site 941639004410 Switch I region; other site 941639004411 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 941639004412 G3 box; other site 941639004413 Switch II region; other site 941639004414 GTP/Mg2+ binding site [chemical binding]; other site 941639004415 G4 box; other site 941639004416 G5 box; other site 941639004417 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 941639004418 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 941639004419 xanthine permease; Region: pbuX; TIGR03173 941639004420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639004421 active site 941639004422 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 941639004423 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 941639004424 active site 941639004425 Zn binding site [ion binding]; other site 941639004426 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 941639004427 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 941639004428 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 941639004429 cell division protein GpsB; Provisional; Region: PRK14127 941639004430 DivIVA domain; Region: DivI1A_domain; TIGR03544 941639004431 hypothetical protein; Provisional; Region: PRK13660 941639004432 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 941639004433 RNase_H superfamily; Region: RNase_H_2; pfam13482 941639004434 active site 941639004435 substrate binding site [chemical binding]; other site 941639004436 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 941639004437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639004438 ATP binding site [chemical binding]; other site 941639004439 putative Mg++ binding site [ion binding]; other site 941639004440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639004441 nucleotide binding region [chemical binding]; other site 941639004442 ATP-binding site [chemical binding]; other site 941639004443 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 941639004444 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941639004445 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 941639004446 putative dimer interface [polypeptide binding]; other site 941639004447 YppG-like protein; Region: YppG; pfam14179 941639004448 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 941639004449 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 941639004450 Transglycosylase; Region: Transgly; pfam00912 941639004451 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 941639004452 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941639004453 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 941639004454 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941639004455 minor groove reading motif; other site 941639004456 helix-hairpin-helix signature motif; other site 941639004457 substrate binding pocket [chemical binding]; other site 941639004458 active site 941639004459 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 941639004460 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 941639004461 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 941639004462 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 941639004463 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 941639004464 homodimer interface [polypeptide binding]; other site 941639004465 motif 1; other site 941639004466 motif 2; other site 941639004467 active site 941639004468 motif 3; other site 941639004469 aspartate aminotransferase; Provisional; Region: PRK05764 941639004470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639004471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639004472 homodimer interface [polypeptide binding]; other site 941639004473 catalytic residue [active] 941639004474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 941639004475 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 941639004476 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 941639004477 active site 941639004478 catalytic site [active] 941639004479 substrate binding site [chemical binding]; other site 941639004480 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 941639004481 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941639004482 putative Mg++ binding site [ion binding]; other site 941639004483 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 941639004484 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 941639004485 tetramerization interface [polypeptide binding]; other site 941639004486 active site 941639004487 pantoate--beta-alanine ligase; Region: panC; TIGR00018 941639004488 Pantoate-beta-alanine ligase; Region: PanC; cd00560 941639004489 active site 941639004490 ATP-binding site [chemical binding]; other site 941639004491 pantoate-binding site; other site 941639004492 HXXH motif; other site 941639004493 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 941639004494 oligomerization interface [polypeptide binding]; other site 941639004495 active site 941639004496 metal binding site [ion binding]; metal-binding site 941639004497 HTH domain; Region: HTH_11; cl17392 941639004498 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 941639004499 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 941639004500 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 941639004501 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 941639004502 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 941639004503 active site 941639004504 NTP binding site [chemical binding]; other site 941639004505 metal binding triad [ion binding]; metal-binding site 941639004506 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 941639004507 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 941639004508 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 941639004509 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 941639004510 dihydrodipicolinate reductase; Provisional; Region: PRK00048 941639004511 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 941639004512 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 941639004513 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 941639004514 homodimer interface [polypeptide binding]; other site 941639004515 metal binding site [ion binding]; metal-binding site 941639004516 Uncharacterized conserved protein [Function unknown]; Region: COG1284 941639004517 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941639004518 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 941639004519 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941639004520 QueT transporter; Region: QueT; pfam06177 941639004521 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 941639004522 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 941639004523 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 941639004524 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 941639004525 interchain domain interface [polypeptide binding]; other site 941639004526 intrachain domain interface; other site 941639004527 Qi binding site; other site 941639004528 Qo binding site; other site 941639004529 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941639004530 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941639004531 cytochrome b6; Provisional; Region: PRK03735 941639004532 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 941639004533 interchain domain interface [polypeptide binding]; other site 941639004534 intrachain domain interface; other site 941639004535 heme bH binding site [chemical binding]; other site 941639004536 Qi binding site; other site 941639004537 heme bL binding site [chemical binding]; other site 941639004538 Qo binding site; other site 941639004539 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 941639004540 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 941639004541 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 941639004542 iron-sulfur cluster [ion binding]; other site 941639004543 [2Fe-2S] cluster binding site [ion binding]; other site 941639004544 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 941639004545 UPF0302 domain; Region: UPF0302; pfam08864 941639004546 IDEAL domain; Region: IDEAL; pfam08858 941639004547 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639004548 binding surface 941639004549 TPR motif; other site 941639004550 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 941639004551 binding surface 941639004552 TPR motif; other site 941639004553 TPR repeat; Region: TPR_11; pfam13414 941639004554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639004555 binding surface 941639004556 TPR motif; other site 941639004557 TPR repeat; Region: TPR_11; pfam13414 941639004558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639004559 binding surface 941639004560 TPR motif; other site 941639004561 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 941639004562 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 941639004563 hinge; other site 941639004564 active site 941639004565 prephenate dehydrogenase; Validated; Region: PRK06545 941639004566 prephenate dehydrogenase; Validated; Region: PRK08507 941639004567 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 941639004568 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 941639004569 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 941639004570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639004571 homodimer interface [polypeptide binding]; other site 941639004572 catalytic residue [active] 941639004573 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 941639004574 homotrimer interaction site [polypeptide binding]; other site 941639004575 active site 941639004576 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 941639004577 active site 941639004578 dimer interface [polypeptide binding]; other site 941639004579 metal binding site [ion binding]; metal-binding site 941639004580 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 941639004581 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 941639004582 Tetramer interface [polypeptide binding]; other site 941639004583 active site 941639004584 FMN-binding site [chemical binding]; other site 941639004585 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 941639004586 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 941639004587 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 941639004588 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 941639004589 active site 941639004590 multimer interface [polypeptide binding]; other site 941639004591 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941639004592 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941639004593 substrate binding pocket [chemical binding]; other site 941639004594 chain length determination region; other site 941639004595 substrate-Mg2+ binding site; other site 941639004596 catalytic residues [active] 941639004597 aspartate-rich region 1; other site 941639004598 active site lid residues [active] 941639004599 aspartate-rich region 2; other site 941639004600 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 941639004601 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639004602 S-adenosylmethionine binding site [chemical binding]; other site 941639004603 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 941639004604 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 941639004605 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 941639004606 IHF dimer interface [polypeptide binding]; other site 941639004607 IHF - DNA interface [nucleotide binding]; other site 941639004608 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 941639004609 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 941639004610 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 941639004611 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 941639004612 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 941639004613 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 941639004614 GTP-binding protein Der; Reviewed; Region: PRK00093 941639004615 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 941639004616 G1 box; other site 941639004617 GTP/Mg2+ binding site [chemical binding]; other site 941639004618 Switch I region; other site 941639004619 G2 box; other site 941639004620 Switch II region; other site 941639004621 G3 box; other site 941639004622 G4 box; other site 941639004623 G5 box; other site 941639004624 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 941639004625 G1 box; other site 941639004626 GTP/Mg2+ binding site [chemical binding]; other site 941639004627 Switch I region; other site 941639004628 G2 box; other site 941639004629 G3 box; other site 941639004630 Switch II region; other site 941639004631 G4 box; other site 941639004632 G5 box; other site 941639004633 YpzI-like protein; Region: YpzI; pfam14140 941639004634 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 941639004635 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 941639004636 RNA binding site [nucleotide binding]; other site 941639004637 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 941639004638 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941639004639 RNA binding site [nucleotide binding]; other site 941639004640 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 941639004641 RNA binding site [nucleotide binding]; other site 941639004642 cytidylate kinase; Provisional; Region: cmk; PRK00023 941639004643 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 941639004644 CMP-binding site; other site 941639004645 The sites determining sugar specificity; other site 941639004646 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 941639004647 Flagellar protein YcgR; Region: YcgR_2; pfam12945 941639004648 PilZ domain; Region: PilZ; pfam07238 941639004649 germination protein YpeB; Region: spore_YpeB; TIGR02889 941639004650 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 941639004651 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 941639004652 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 941639004653 Protease prsW family; Region: PrsW-protease; pfam13367 941639004654 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 941639004655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639004656 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 941639004657 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 941639004658 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 941639004659 NAD(P) binding site [chemical binding]; other site 941639004660 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 941639004661 phosphodiesterase YaeI; Provisional; Region: PRK11340 941639004662 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 941639004663 putative active site [active] 941639004664 putative metal binding site [ion binding]; other site 941639004665 Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546 941639004666 dinuclear metal binding motif [ion binding]; other site 941639004667 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 941639004668 CAAX protease self-immunity; Region: Abi; pfam02517 941639004669 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 941639004670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639004671 ATP binding site [chemical binding]; other site 941639004672 putative Mg++ binding site [ion binding]; other site 941639004673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639004674 nucleotide binding region [chemical binding]; other site 941639004675 ATP-binding site [chemical binding]; other site 941639004676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 941639004677 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 941639004678 Predicted membrane protein [Function unknown]; Region: COG3601 941639004679 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 941639004680 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941639004681 Peptidase family M23; Region: Peptidase_M23; pfam01551 941639004682 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 941639004683 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639004684 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 941639004685 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639004686 dimerization interface [polypeptide binding]; other site 941639004687 PAS domain; Region: PAS; smart00091 941639004688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639004689 dimer interface [polypeptide binding]; other site 941639004690 phosphorylation site [posttranslational modification] 941639004691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639004692 ATP binding site [chemical binding]; other site 941639004693 Mg2+ binding site [ion binding]; other site 941639004694 G-X-G motif; other site 941639004695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639004696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639004697 active site 941639004698 phosphorylation site [posttranslational modification] 941639004699 intermolecular recognition site; other site 941639004700 dimerization interface [polypeptide binding]; other site 941639004701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639004702 DNA binding site [nucleotide binding] 941639004703 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 941639004704 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 941639004705 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 941639004706 ResB-like family; Region: ResB; pfam05140 941639004707 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 941639004708 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941639004709 catalytic residues [active] 941639004710 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 941639004711 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639004712 RNA binding surface [nucleotide binding]; other site 941639004713 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 941639004714 active site 941639004715 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 941639004716 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 941639004717 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 941639004718 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941639004719 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 941639004720 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 941639004721 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 941639004722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639004723 Coenzyme A binding pocket [chemical binding]; other site 941639004724 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 941639004725 dimer interface [polypeptide binding]; other site 941639004726 active site 941639004727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941639004728 substrate binding site [chemical binding]; other site 941639004729 catalytic residues [active] 941639004730 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 941639004731 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 941639004732 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 941639004733 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 941639004734 sporulation sigma factor SigF; Validated; Region: PRK05572 941639004735 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639004736 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941639004737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639004738 DNA binding residues [nucleotide binding] 941639004739 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 941639004740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639004741 ATP binding site [chemical binding]; other site 941639004742 Mg2+ binding site [ion binding]; other site 941639004743 G-X-G motif; other site 941639004744 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 941639004745 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 941639004746 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 941639004747 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 941639004748 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 941639004749 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 941639004750 active site 941639004751 Int/Topo IB signature motif; other site 941639004752 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 941639004753 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941639004754 metal binding site 2 [ion binding]; metal-binding site 941639004755 putative DNA binding helix; other site 941639004756 metal binding site 1 [ion binding]; metal-binding site 941639004757 dimer interface [polypeptide binding]; other site 941639004758 structural Zn2+ binding site [ion binding]; other site 941639004759 Integral membrane protein DUF95; Region: DUF95; cl00572 941639004760 TIGR00375 family protein; Region: TIGR00375 941639004761 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941639004762 active site 941639004763 PHP-associated; Region: PHP_C; pfam13263 941639004764 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 941639004765 dimer interface [polypeptide binding]; other site 941639004766 ADP-ribose binding site [chemical binding]; other site 941639004767 active site 941639004768 nudix motif; other site 941639004769 metal binding site [ion binding]; metal-binding site 941639004770 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 941639004771 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639004772 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639004773 active site 941639004774 catalytic tetrad [active] 941639004775 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 941639004776 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 941639004777 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 941639004778 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 941639004779 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639004780 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 941639004781 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639004782 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639004783 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 941639004784 active site 941639004785 YolD-like protein; Region: YolD; pfam08863 941639004786 DNA polymerase IV; Reviewed; Region: PRK03103 941639004787 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 941639004788 active site 941639004789 DNA binding site [nucleotide binding] 941639004790 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 941639004791 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 941639004792 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639004793 NAD(P) binding site [chemical binding]; other site 941639004794 active site 941639004795 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 941639004796 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 941639004797 ribonuclease Z; Region: RNase_Z; TIGR02651 941639004798 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 941639004799 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 941639004800 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 941639004801 DNA polymerase IV; Validated; Region: PRK01810 941639004802 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 941639004803 active site 941639004804 DNA binding site [nucleotide binding] 941639004805 CheW-like domain; Region: CheW; pfam01584 941639004806 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 941639004807 peptidase T-like protein; Region: PepT-like; TIGR01883 941639004808 metal binding site [ion binding]; metal-binding site 941639004809 putative dimer interface [polypeptide binding]; other site 941639004810 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941639004811 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 941639004812 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 941639004813 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 941639004814 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 941639004815 putative substrate binding site [chemical binding]; other site 941639004816 putative ATP binding site [chemical binding]; other site 941639004817 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 941639004818 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941639004819 E3 interaction surface; other site 941639004820 lipoyl attachment site [posttranslational modification]; other site 941639004821 e3 binding domain; Region: E3_binding; pfam02817 941639004822 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 941639004823 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 941639004824 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 941639004825 alpha subunit interface [polypeptide binding]; other site 941639004826 TPP binding site [chemical binding]; other site 941639004827 heterodimer interface [polypeptide binding]; other site 941639004828 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941639004829 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 941639004830 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 941639004831 tetramer interface [polypeptide binding]; other site 941639004832 TPP-binding site [chemical binding]; other site 941639004833 heterodimer interface [polypeptide binding]; other site 941639004834 phosphorylation loop region [posttranslational modification] 941639004835 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 941639004836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639004837 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941639004838 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 941639004839 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 941639004840 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 941639004841 NAD binding site [chemical binding]; other site 941639004842 Phe binding site; other site 941639004843 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941639004844 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 941639004845 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941639004846 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 941639004847 active site 941639004848 metal binding site [ion binding]; metal-binding site 941639004849 catalytic site [active] 941639004850 dimer interface [polypeptide binding]; other site 941639004851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639004852 active site 941639004853 phosphorylation site [posttranslational modification] 941639004854 intermolecular recognition site; other site 941639004855 dimerization interface [polypeptide binding]; other site 941639004856 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 941639004857 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 941639004858 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 941639004859 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 941639004860 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 941639004861 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941639004862 Walker A/P-loop; other site 941639004863 ATP binding site [chemical binding]; other site 941639004864 Q-loop/lid; other site 941639004865 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 941639004866 ABC transporter signature motif; other site 941639004867 Walker B; other site 941639004868 D-loop; other site 941639004869 H-loop/switch region; other site 941639004870 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 941639004871 arginine repressor; Provisional; Region: PRK04280 941639004872 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 941639004873 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 941639004874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639004875 RNA binding surface [nucleotide binding]; other site 941639004876 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 941639004877 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 941639004878 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 941639004879 TPP-binding site; other site 941639004880 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 941639004881 PYR/PP interface [polypeptide binding]; other site 941639004882 dimer interface [polypeptide binding]; other site 941639004883 TPP binding site [chemical binding]; other site 941639004884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 941639004885 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 941639004886 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 941639004887 substrate binding pocket [chemical binding]; other site 941639004888 substrate-Mg2+ binding site; other site 941639004889 catalytic residues [active] 941639004890 aspartate-rich region 1; other site 941639004891 active site lid residues [active] 941639004892 aspartate-rich region 2; other site 941639004893 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 941639004894 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 941639004895 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 941639004896 generic binding surface II; other site 941639004897 generic binding surface I; other site 941639004898 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 941639004899 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 941639004900 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 941639004901 homodimer interface [polypeptide binding]; other site 941639004902 NADP binding site [chemical binding]; other site 941639004903 substrate binding site [chemical binding]; other site 941639004904 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 941639004905 putative RNA binding site [nucleotide binding]; other site 941639004906 Asp23 family; Region: Asp23; pfam03780 941639004907 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 941639004908 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 941639004909 ATP-grasp domain; Region: ATP-grasp_4; cl17255 941639004910 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 941639004911 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 941639004912 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941639004913 carboxyltransferase (CT) interaction site; other site 941639004914 biotinylation site [posttranslational modification]; other site 941639004915 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 941639004916 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 941639004917 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 941639004918 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 941639004919 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 941639004920 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 941639004921 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 941639004922 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 941639004923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639004924 Walker A/P-loop; other site 941639004925 ATP binding site [chemical binding]; other site 941639004926 Q-loop/lid; other site 941639004927 ABC transporter signature motif; other site 941639004928 Walker B; other site 941639004929 H-loop/switch region; other site 941639004930 elongation factor P; Validated; Region: PRK00529 941639004931 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 941639004932 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 941639004933 RNA binding site [nucleotide binding]; other site 941639004934 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 941639004935 RNA binding site [nucleotide binding]; other site 941639004936 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941639004937 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941639004938 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 941639004939 active site 941639004940 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 941639004941 Dehydroquinase class II; Region: DHquinase_II; pfam01220 941639004942 trimer interface [polypeptide binding]; other site 941639004943 active site 941639004944 dimer interface [polypeptide binding]; other site 941639004945 Conserved membrane protein YqhR; Region: YqhR; pfam11085 941639004946 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 941639004947 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 941639004948 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 941639004949 active site 941639004950 nucleophile elbow; other site 941639004951 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 941639004952 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 941639004953 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 941639004954 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 941639004955 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 941639004956 active site 941639004957 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 941639004958 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941639004959 active site residue [active] 941639004960 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 941639004961 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941639004962 tetramer interface [polypeptide binding]; other site 941639004963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639004964 catalytic residue [active] 941639004965 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 941639004966 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 941639004967 tetramer interface [polypeptide binding]; other site 941639004968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639004969 catalytic residue [active] 941639004970 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 941639004971 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 941639004972 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 941639004973 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941639004974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639004975 ATP binding site [chemical binding]; other site 941639004976 putative Mg++ binding site [ion binding]; other site 941639004977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639004978 nucleotide binding region [chemical binding]; other site 941639004979 ATP-binding site [chemical binding]; other site 941639004980 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 941639004981 shikimate kinase; Reviewed; Region: aroK; PRK00131 941639004982 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 941639004983 ADP binding site [chemical binding]; other site 941639004984 magnesium binding site [ion binding]; other site 941639004985 putative shikimate binding site; other site 941639004986 ComG operon protein 7; Region: ComGG; pfam14173 941639004987 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 941639004988 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 941639004989 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 941639004990 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941639004991 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941639004992 Type II/IV secretion system protein; Region: T2SE; pfam00437 941639004993 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941639004994 Walker A motif; other site 941639004995 ATP binding site [chemical binding]; other site 941639004996 Walker B motif; other site 941639004997 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941639004998 dimerization interface [polypeptide binding]; other site 941639004999 putative DNA binding site [nucleotide binding]; other site 941639005000 Predicted transcriptional regulator [Transcription]; Region: COG2345 941639005001 putative Zn2+ binding site [ion binding]; other site 941639005002 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 941639005003 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 941639005004 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 941639005005 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 941639005006 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 941639005007 Rhomboid family; Region: Rhomboid; pfam01694 941639005008 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 941639005009 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941639005010 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 941639005011 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 941639005012 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639005013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639005014 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 941639005015 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 941639005016 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 941639005017 GcpE protein; Region: GcpE; pfam04551 941639005018 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941639005019 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 941639005020 Uncharacterized conserved protein [Function unknown]; Region: COG5663 941639005021 ferric uptake regulator; Provisional; Region: fur; PRK09462 941639005022 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941639005023 metal binding site 2 [ion binding]; metal-binding site 941639005024 putative DNA binding helix; other site 941639005025 metal binding site 1 [ion binding]; metal-binding site 941639005026 dimer interface [polypeptide binding]; other site 941639005027 structural Zn2+ binding site [ion binding]; other site 941639005028 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 941639005029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 941639005030 ABC-ATPase subunit interface; other site 941639005031 dimer interface [polypeptide binding]; other site 941639005032 putative PBP binding regions; other site 941639005033 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 941639005034 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 941639005035 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 941639005036 Protein of unknown function (DUF1640); Region: DUF1640; pfam07798 941639005037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941639005038 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941639005039 NlpC/P60 family; Region: NLPC_P60; pfam00877 941639005040 endonuclease IV; Provisional; Region: PRK01060 941639005041 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 941639005042 AP (apurinic/apyrimidinic) site pocket; other site 941639005043 DNA interaction; other site 941639005044 Metal-binding active site; metal-binding site 941639005045 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941639005046 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941639005047 ATP binding site [chemical binding]; other site 941639005048 Mg++ binding site [ion binding]; other site 941639005049 motif III; other site 941639005050 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639005051 nucleotide binding region [chemical binding]; other site 941639005052 ATP-binding site [chemical binding]; other site 941639005053 YqfQ-like protein; Region: YqfQ; pfam14181 941639005054 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 941639005055 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 941639005056 Uncharacterized conserved protein [Function unknown]; Region: COG0327 941639005057 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 941639005058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 941639005059 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 941639005060 Uncharacterized conserved protein [Function unknown]; Region: COG0327 941639005061 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 941639005062 Family of unknown function (DUF633); Region: DUF633; pfam04816 941639005063 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 941639005064 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 941639005065 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 941639005066 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 941639005067 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 941639005068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639005069 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941639005070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639005071 DNA binding residues [nucleotide binding] 941639005072 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 941639005073 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 941639005074 active site 941639005075 metal binding site [ion binding]; metal-binding site 941639005076 interdomain interaction site; other site 941639005077 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 941639005078 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 941639005079 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 941639005080 HTH domain; Region: HTH_11; pfam08279 941639005081 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 941639005082 FOG: CBS domain [General function prediction only]; Region: COG0517 941639005083 DNA repair protein RecO; Region: reco; TIGR00613 941639005084 Recombination protein O N terminal; Region: RecO_N; pfam11967 941639005085 Recombination protein O C terminal; Region: RecO_C; pfam02565 941639005086 YqzL-like protein; Region: YqzL; pfam14006 941639005087 GTPase Era; Reviewed; Region: era; PRK00089 941639005088 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 941639005089 G1 box; other site 941639005090 GTP/Mg2+ binding site [chemical binding]; other site 941639005091 Switch I region; other site 941639005092 G2 box; other site 941639005093 Switch II region; other site 941639005094 G3 box; other site 941639005095 G4 box; other site 941639005096 G5 box; other site 941639005097 KH domain; Region: KH_2; pfam07650 941639005098 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 941639005099 metal-binding heat shock protein; Provisional; Region: PRK00016 941639005100 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 941639005101 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 941639005102 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639005103 Zn2+ binding site [ion binding]; other site 941639005104 Mg2+ binding site [ion binding]; other site 941639005105 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 941639005106 PhoH-like protein; Region: PhoH; pfam02562 941639005107 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 941639005108 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 941639005109 Yqey-like protein; Region: YqeY; pfam09424 941639005110 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 941639005111 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 941639005112 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941639005113 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 941639005114 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 941639005115 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 941639005116 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639005117 FeS/SAM binding site; other site 941639005118 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 941639005119 RNA methyltransferase, RsmE family; Region: TIGR00046 941639005120 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 941639005121 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941639005122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639005123 S-adenosylmethionine binding site [chemical binding]; other site 941639005124 chaperone protein DnaJ; Provisional; Region: PRK14280 941639005125 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 941639005126 HSP70 interaction site [polypeptide binding]; other site 941639005127 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 941639005128 substrate binding site [polypeptide binding]; other site 941639005129 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 941639005130 Zn binding sites [ion binding]; other site 941639005131 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 941639005132 dimer interface [polypeptide binding]; other site 941639005133 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 941639005134 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 941639005135 nucleotide binding site [chemical binding]; other site 941639005136 NEF interaction site [polypeptide binding]; other site 941639005137 SBD interface [polypeptide binding]; other site 941639005138 heat shock protein GrpE; Provisional; Region: PRK14140 941639005139 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 941639005140 dimer interface [polypeptide binding]; other site 941639005141 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 941639005142 HrcA protein C terminal domain; Region: HrcA; pfam01628 941639005143 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 941639005144 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639005145 FeS/SAM binding site; other site 941639005146 HemN C-terminal domain; Region: HemN_C; pfam06969 941639005147 GTP-binding protein LepA; Provisional; Region: PRK05433 941639005148 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 941639005149 G1 box; other site 941639005150 putative GEF interaction site [polypeptide binding]; other site 941639005151 GTP/Mg2+ binding site [chemical binding]; other site 941639005152 Switch I region; other site 941639005153 G2 box; other site 941639005154 G3 box; other site 941639005155 Switch II region; other site 941639005156 G4 box; other site 941639005157 G5 box; other site 941639005158 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 941639005159 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 941639005160 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 941639005161 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 941639005162 stage II sporulation protein P; Region: spore_II_P; TIGR02867 941639005163 germination protease; Provisional; Region: PRK02858 941639005164 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 941639005165 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 941639005166 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 941639005167 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 941639005168 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 941639005169 Competence protein; Region: Competence; pfam03772 941639005170 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 941639005171 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941639005172 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 941639005173 active site 941639005174 Zn binding site [ion binding]; other site 941639005175 SLBB domain; Region: SLBB; pfam10531 941639005176 comEA protein; Region: comE; TIGR01259 941639005177 Helix-hairpin-helix motif; Region: HHH; pfam00633 941639005178 late competence protein ComER; Validated; Region: PRK07680 941639005179 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 941639005180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639005181 S-adenosylmethionine binding site [chemical binding]; other site 941639005182 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 941639005183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639005184 Zn2+ binding site [ion binding]; other site 941639005185 Mg2+ binding site [ion binding]; other site 941639005186 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 941639005187 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 941639005188 active site 941639005189 (T/H)XGH motif; other site 941639005190 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 941639005191 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 941639005192 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 941639005193 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 941639005194 shikimate binding site; other site 941639005195 NAD(P) binding site [chemical binding]; other site 941639005196 GTPase YqeH; Provisional; Region: PRK13796 941639005197 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 941639005198 GTP/Mg2+ binding site [chemical binding]; other site 941639005199 G4 box; other site 941639005200 G5 box; other site 941639005201 G1 box; other site 941639005202 Switch I region; other site 941639005203 G2 box; other site 941639005204 G3 box; other site 941639005205 Switch II region; other site 941639005206 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 941639005207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639005208 active site 941639005209 motif I; other site 941639005210 motif II; other site 941639005211 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 941639005212 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 941639005213 Cysteine-rich domain; Region: CCG; pfam02754 941639005214 Cysteine-rich domain; Region: CCG; pfam02754 941639005215 FAD binding domain; Region: FAD_binding_4; pfam01565 941639005216 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 941639005217 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 941639005218 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 941639005219 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 941639005220 multicopper oxidase; Provisional; Region: PRK10965 941639005221 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 941639005222 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 941639005223 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941639005224 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 941639005225 putative dimer interface [polypeptide binding]; other site 941639005226 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 941639005227 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 941639005228 catalytic residues [active] 941639005229 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941639005230 active site residue [active] 941639005231 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 941639005232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639005233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639005234 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 941639005235 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 941639005236 active site residue [active] 941639005237 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941639005238 CPxP motif; other site 941639005239 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941639005240 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639005241 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 941639005242 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 941639005243 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 941639005244 putative dimer interface [polypeptide binding]; other site 941639005245 Short C-terminal domain; Region: SHOCT; pfam09851 941639005246 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 941639005247 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941639005248 catalytic residues [active] 941639005249 Repair protein; Region: Repair_PSII; pfam04536 941639005250 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 941639005251 CrcB-like protein; Region: CRCB; cl09114 941639005252 CCC1-related family of proteins; Region: CCC1_like; cl00278 941639005253 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 941639005254 Sporulation inhibitor A; Region: Sda; pfam08970 941639005255 sporulation sigma factor SigK; Reviewed; Region: PRK05803 941639005256 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639005257 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639005258 DNA binding residues [nucleotide binding] 941639005259 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 941639005260 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 941639005261 catalytic residue [active] 941639005262 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 941639005263 catalytic residues [active] 941639005264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639005265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639005266 peroxiredoxin; Region: AhpC; TIGR03137 941639005267 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 941639005268 dimer interface [polypeptide binding]; other site 941639005269 decamer (pentamer of dimers) interface [polypeptide binding]; other site 941639005270 catalytic triad [active] 941639005271 peroxidatic and resolving cysteines [active] 941639005272 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 941639005273 YrhC-like protein; Region: YrhC; pfam14143 941639005274 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 941639005275 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 941639005276 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 941639005277 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 941639005278 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 941639005279 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 941639005280 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 941639005281 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 941639005282 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 941639005283 ATP-binding site [chemical binding]; other site 941639005284 Sugar specificity; other site 941639005285 Pyrimidine base specificity; other site 941639005286 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 941639005287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639005288 S-adenosylmethionine binding site [chemical binding]; other site 941639005289 YceG-like family; Region: YceG; pfam02618 941639005290 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 941639005291 dimerization interface [polypeptide binding]; other site 941639005292 hypothetical protein; Provisional; Region: PRK13678 941639005293 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 941639005294 hypothetical protein; Provisional; Region: PRK05473 941639005295 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 941639005296 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 941639005297 motif 1; other site 941639005298 active site 941639005299 motif 2; other site 941639005300 motif 3; other site 941639005301 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 941639005302 DHHA1 domain; Region: DHHA1; pfam02272 941639005303 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 941639005304 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941639005305 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 941639005306 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 941639005307 AAA domain; Region: AAA_30; pfam13604 941639005308 Family description; Region: UvrD_C_2; pfam13538 941639005309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639005310 binding surface 941639005311 TPR motif; other site 941639005312 TPR repeat; Region: TPR_11; pfam13414 941639005313 Tetratricopeptide repeat; Region: TPR_16; pfam13432 941639005314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 941639005315 binding surface 941639005316 TPR motif; other site 941639005317 TPR repeat; Region: TPR_11; pfam13414 941639005318 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 941639005319 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 941639005320 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 941639005321 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941639005322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941639005323 catalytic residue [active] 941639005324 Predicted transcriptional regulator [Transcription]; Region: COG1959 941639005325 Transcriptional regulator; Region: Rrf2; pfam02082 941639005326 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 941639005327 classical (c) SDRs; Region: SDR_c; cd05233 941639005328 NAD(P) binding site [chemical binding]; other site 941639005329 active site 941639005330 recombination factor protein RarA; Reviewed; Region: PRK13342 941639005331 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005332 Walker A motif; other site 941639005333 ATP binding site [chemical binding]; other site 941639005334 Walker B motif; other site 941639005335 arginine finger; other site 941639005336 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 941639005337 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 941639005338 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 941639005339 putative ATP binding site [chemical binding]; other site 941639005340 putative substrate interface [chemical binding]; other site 941639005341 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 941639005342 Sodium Bile acid symporter family; Region: SBF; cl17470 941639005343 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 941639005344 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 941639005345 dimer interface [polypeptide binding]; other site 941639005346 anticodon binding site; other site 941639005347 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 941639005348 homodimer interface [polypeptide binding]; other site 941639005349 motif 1; other site 941639005350 active site 941639005351 motif 2; other site 941639005352 GAD domain; Region: GAD; pfam02938 941639005353 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 941639005354 motif 3; other site 941639005355 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 941639005356 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 941639005357 dimer interface [polypeptide binding]; other site 941639005358 motif 1; other site 941639005359 active site 941639005360 motif 2; other site 941639005361 motif 3; other site 941639005362 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 941639005363 anticodon binding site; other site 941639005364 Bacterial SH3 domain homologues; Region: SH3b; smart00287 941639005365 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639005366 Bacterial SH3 domain; Region: SH3_3; pfam08239 941639005367 Bacterial SH3 domain; Region: SH3_3; cl17532 941639005368 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941639005369 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941639005370 active site 941639005371 metal binding site [ion binding]; metal-binding site 941639005372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639005373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639005374 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 941639005375 carboxyltransferase (CT) interaction site; other site 941639005376 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 941639005377 biotinylation site [posttranslational modification]; other site 941639005378 HlyD family secretion protein; Region: HlyD_3; pfam13437 941639005379 Transcriptional regulators [Transcription]; Region: MarR; COG1846 941639005380 MarR family; Region: MarR; pfam01047 941639005381 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 941639005382 putative active site [active] 941639005383 dimerization interface [polypeptide binding]; other site 941639005384 putative tRNAtyr binding site [nucleotide binding]; other site 941639005385 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 941639005386 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639005387 Zn2+ binding site [ion binding]; other site 941639005388 Mg2+ binding site [ion binding]; other site 941639005389 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941639005390 synthetase active site [active] 941639005391 NTP binding site [chemical binding]; other site 941639005392 metal binding site [ion binding]; metal-binding site 941639005393 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 941639005394 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 941639005395 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639005396 active site 941639005397 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 941639005398 DHH family; Region: DHH; pfam01368 941639005399 DHHA1 domain; Region: DHHA1; pfam02272 941639005400 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 941639005401 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 941639005402 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 941639005403 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 941639005404 Protein export membrane protein; Region: SecD_SecF; pfam02355 941639005405 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 941639005406 stage V sporulation protein B; Region: spore_V_B; TIGR02900 941639005407 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 941639005408 Predicted membrane protein [Function unknown]; Region: COG2323 941639005409 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 941639005410 Preprotein translocase subunit; Region: YajC; pfam02699 941639005411 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 941639005412 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 941639005413 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 941639005414 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 941639005415 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 941639005416 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 941639005417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005418 Walker A motif; other site 941639005419 ATP binding site [chemical binding]; other site 941639005420 Walker B motif; other site 941639005421 arginine finger; other site 941639005422 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 941639005423 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 941639005424 RuvA N terminal domain; Region: RuvA_N; pfam01330 941639005425 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 941639005426 hypothetical protein; Validated; Region: PRK00110 941639005427 Phosphotransferase enzyme family; Region: APH; pfam01636 941639005428 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941639005429 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 941639005430 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639005431 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 941639005432 HTH domain; Region: HTH_11; pfam08279 941639005433 3H domain; Region: 3H; pfam02829 941639005434 prephenate dehydratase; Provisional; Region: PRK11898 941639005435 Prephenate dehydratase; Region: PDT; pfam00800 941639005436 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 941639005437 putative L-Phe binding site [chemical binding]; other site 941639005438 hypothetical protein; Provisional; Region: PRK04435 941639005439 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 941639005440 GTPase CgtA; Reviewed; Region: obgE; PRK12297 941639005441 GTP1/OBG; Region: GTP1_OBG; pfam01018 941639005442 Obg GTPase; Region: Obg; cd01898 941639005443 G1 box; other site 941639005444 GTP/Mg2+ binding site [chemical binding]; other site 941639005445 Switch I region; other site 941639005446 G2 box; other site 941639005447 G3 box; other site 941639005448 Switch II region; other site 941639005449 G4 box; other site 941639005450 G5 box; other site 941639005451 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 941639005452 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 941639005453 hypothetical protein; Provisional; Region: PRK14553 941639005454 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 941639005455 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 941639005456 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 941639005457 homodimer interface [polypeptide binding]; other site 941639005458 oligonucleotide binding site [chemical binding]; other site 941639005459 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 941639005460 Peptidase family M50; Region: Peptidase_M50; pfam02163 941639005461 active site 941639005462 putative substrate binding region [chemical binding]; other site 941639005463 Peptidase family M23; Region: Peptidase_M23; pfam01551 941639005464 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 941639005465 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 941639005466 Switch I; other site 941639005467 Switch II; other site 941639005468 septum formation inhibitor; Reviewed; Region: minC; PRK00513 941639005469 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 941639005470 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 941639005471 rod shape-determining protein MreC; Provisional; Region: PRK13922 941639005472 Protein of unknown function (DUF972); Region: DUF972; pfam06156 941639005473 rod shape-determining protein MreC; Region: MreC; pfam04085 941639005474 rod shape-determining protein MreB; Provisional; Region: PRK13927 941639005475 MreB and similar proteins; Region: MreB_like; cd10225 941639005476 nucleotide binding site [chemical binding]; other site 941639005477 Mg binding site [ion binding]; other site 941639005478 putative protofilament interaction site [polypeptide binding]; other site 941639005479 RodZ interaction site [polypeptide binding]; other site 941639005480 hypothetical protein; Reviewed; Region: PRK00024 941639005481 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 941639005482 MPN+ (JAMM) motif; other site 941639005483 Zinc-binding site [ion binding]; other site 941639005484 Transposase; Region: DEDD_Tnp_IS110; pfam01548 941639005485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 941639005486 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 941639005487 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 941639005488 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 941639005489 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 941639005490 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 941639005491 Competence protein A; Region: Competence_A; pfam11104 941639005492 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 941639005493 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941639005494 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 941639005495 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 941639005496 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 941639005497 Walker A motif; other site 941639005498 ATP binding site [chemical binding]; other site 941639005499 Walker B motif; other site 941639005500 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 941639005501 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 941639005502 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 941639005503 Walker A motif; other site 941639005504 ATP binding site [chemical binding]; other site 941639005505 Walker B motif; other site 941639005506 VanW like protein; Region: VanW; pfam04294 941639005507 G5 domain; Region: G5; pfam07501 941639005508 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 941639005509 PRC-barrel domain; Region: PRC; pfam05239 941639005510 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 941639005511 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 941639005512 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 941639005513 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 941639005514 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 941639005515 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941639005516 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941639005517 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 941639005518 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 941639005519 active site 941639005520 HIGH motif; other site 941639005521 nucleotide binding site [chemical binding]; other site 941639005522 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941639005523 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 941639005524 active site 941639005525 KMSKS motif; other site 941639005526 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 941639005527 tRNA binding surface [nucleotide binding]; other site 941639005528 anticodon binding site; other site 941639005529 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 941639005530 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 941639005531 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 941639005532 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639005533 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 941639005534 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941639005535 inhibitor-cofactor binding pocket; inhibition site 941639005536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639005537 catalytic residue [active] 941639005538 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 941639005539 dimer interface [polypeptide binding]; other site 941639005540 active site 941639005541 Schiff base residues; other site 941639005542 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 941639005543 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 941639005544 active site 941639005545 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 941639005546 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 941639005547 domain interfaces; other site 941639005548 active site 941639005549 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 941639005550 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 941639005551 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 941639005552 tRNA; other site 941639005553 putative tRNA binding site [nucleotide binding]; other site 941639005554 putative NADP binding site [chemical binding]; other site 941639005555 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 941639005556 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 941639005557 G1 box; other site 941639005558 GTP/Mg2+ binding site [chemical binding]; other site 941639005559 Switch I region; other site 941639005560 G2 box; other site 941639005561 G3 box; other site 941639005562 Switch II region; other site 941639005563 G4 box; other site 941639005564 G5 box; other site 941639005565 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 941639005566 Found in ATP-dependent protease La (LON); Region: LON; smart00464 941639005567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005568 Walker A motif; other site 941639005569 ATP binding site [chemical binding]; other site 941639005570 Walker B motif; other site 941639005571 arginine finger; other site 941639005572 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941639005573 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 941639005574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005575 Walker A motif; other site 941639005576 ATP binding site [chemical binding]; other site 941639005577 Walker B motif; other site 941639005578 arginine finger; other site 941639005579 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 941639005580 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 941639005581 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 941639005582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005583 Walker A motif; other site 941639005584 ATP binding site [chemical binding]; other site 941639005585 Walker B motif; other site 941639005586 arginine finger; other site 941639005587 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 941639005588 trigger factor; Provisional; Region: tig; PRK01490 941639005589 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 941639005590 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 941639005591 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 941639005592 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 941639005593 active site 941639005594 metal binding site [ion binding]; metal-binding site 941639005595 homotetramer interface [polypeptide binding]; other site 941639005596 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 941639005597 active site 941639005598 dimerization interface [polypeptide binding]; other site 941639005599 Spore germination protein [General function prediction only]; Region: COG5401 941639005600 Sporulation and spore germination; Region: Germane; pfam10646 941639005601 Sporulation and spore germination; Region: Germane; smart00909 941639005602 Coat F domain; Region: Coat_F; cl17715 941639005603 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 941639005604 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941639005605 NAD binding site [chemical binding]; other site 941639005606 catalytic Zn binding site [ion binding]; other site 941639005607 structural Zn binding site [ion binding]; other site 941639005608 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 941639005609 glutamate racemase; Provisional; Region: PRK00865 941639005610 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941639005611 MarR family; Region: MarR; pfam01047 941639005612 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 941639005613 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 941639005614 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 941639005615 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 941639005616 active site 941639005617 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 941639005618 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 941639005619 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 941639005620 L-aspartate oxidase; Provisional; Region: PRK06175 941639005621 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 941639005622 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 941639005623 proximal heme binding site [chemical binding]; other site 941639005624 putative dimer interface [polypeptide binding]; other site 941639005625 putative Iron-sulfur protein interface [polypeptide binding]; other site 941639005626 distal heme binding site [chemical binding]; other site 941639005627 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 941639005628 aspartate kinase; Reviewed; Region: PRK06635 941639005629 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 941639005630 putative nucleotide binding site [chemical binding]; other site 941639005631 putative catalytic residues [active] 941639005632 putative Mg ion binding site [ion binding]; other site 941639005633 putative aspartate binding site [chemical binding]; other site 941639005634 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 941639005635 putative allosteric regulatory site; other site 941639005636 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 941639005637 putative allosteric regulatory residue; other site 941639005638 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 941639005639 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 941639005640 GIY-YIG motif/motif A; other site 941639005641 active site 941639005642 catalytic site [active] 941639005643 putative DNA binding site [nucleotide binding]; other site 941639005644 metal binding site [ion binding]; metal-binding site 941639005645 UvrB/uvrC motif; Region: UVR; pfam02151 941639005646 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 941639005647 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941639005648 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 941639005649 catalytic residues [active] 941639005650 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 941639005651 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 941639005652 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 941639005653 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 941639005654 Ligand binding site [chemical binding]; other site 941639005655 Electron transfer flavoprotein domain; Region: ETF; pfam01012 941639005656 enoyl-CoA hydratase; Provisional; Region: PRK07658 941639005657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941639005658 substrate binding site [chemical binding]; other site 941639005659 oxyanion hole (OAH) forming residues; other site 941639005660 trimer interface [polypeptide binding]; other site 941639005661 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941639005662 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 941639005663 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 941639005664 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 941639005665 acyl-activating enzyme (AAE) consensus motif; other site 941639005666 putative AMP binding site [chemical binding]; other site 941639005667 putative active site [active] 941639005668 putative CoA binding site [chemical binding]; other site 941639005669 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 941639005670 MutS domain III; Region: MutS_III; pfam05192 941639005671 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 941639005672 Walker A/P-loop; other site 941639005673 ATP binding site [chemical binding]; other site 941639005674 Q-loop/lid; other site 941639005675 ABC transporter signature motif; other site 941639005676 Walker B; other site 941639005677 D-loop; other site 941639005678 H-loop/switch region; other site 941639005679 Smr domain; Region: Smr; pfam01713 941639005680 hypothetical protein; Provisional; Region: PRK08609 941639005681 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 941639005682 active site 941639005683 primer binding site [nucleotide binding]; other site 941639005684 NTP binding site [chemical binding]; other site 941639005685 metal binding triad [ion binding]; metal-binding site 941639005686 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 941639005687 active site 941639005688 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 941639005689 Colicin V production protein; Region: Colicin_V; pfam02674 941639005690 Cell division protein ZapA; Region: ZapA; cl01146 941639005691 ribonuclease HIII; Provisional; Region: PRK00996 941639005692 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 941639005693 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 941639005694 RNA/DNA hybrid binding site [nucleotide binding]; other site 941639005695 active site 941639005696 Nuclease-related domain; Region: NERD; pfam08378 941639005697 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 941639005698 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 941639005699 putative tRNA-binding site [nucleotide binding]; other site 941639005700 B3/4 domain; Region: B3_4; pfam03483 941639005701 tRNA synthetase B5 domain; Region: B5; smart00874 941639005702 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 941639005703 dimer interface [polypeptide binding]; other site 941639005704 motif 1; other site 941639005705 motif 3; other site 941639005706 motif 2; other site 941639005707 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 941639005708 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 941639005709 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 941639005710 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 941639005711 dimer interface [polypeptide binding]; other site 941639005712 motif 1; other site 941639005713 active site 941639005714 motif 2; other site 941639005715 motif 3; other site 941639005716 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 941639005717 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 941639005718 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 941639005719 Small, acid-soluble spore protein I; Region: SSPI; pfam14098 941639005720 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 941639005721 Predicted transcriptional regulators [Transcription]; Region: COG1695 941639005722 Transcriptional regulator PadR-like family; Region: PadR; cl17335 941639005723 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 941639005724 Ligand Binding Site [chemical binding]; other site 941639005725 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 941639005726 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 941639005727 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 941639005728 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941639005729 Predicted flavoprotein [General function prediction only]; Region: COG0431 941639005730 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 941639005731 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 941639005732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 941639005733 active site 941639005734 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941639005735 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 941639005736 trimer interface [polypeptide binding]; other site 941639005737 active site 941639005738 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 941639005739 23S rRNA binding site [nucleotide binding]; other site 941639005740 L21 binding site [polypeptide binding]; other site 941639005741 L13 binding site [polypeptide binding]; other site 941639005742 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 941639005743 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 941639005744 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 941639005745 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 941639005746 H+ Antiporter protein; Region: 2A0121; TIGR00900 941639005747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639005748 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 941639005749 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 941639005750 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 941639005751 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 941639005752 active site 941639005753 dimer interface [polypeptide binding]; other site 941639005754 motif 1; other site 941639005755 motif 2; other site 941639005756 motif 3; other site 941639005757 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 941639005758 anticodon binding site; other site 941639005759 YtxC-like family; Region: YtxC; pfam08812 941639005760 primosomal protein DnaI; Reviewed; Region: PRK08939 941639005761 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 941639005762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005763 Walker A motif; other site 941639005764 ATP binding site [chemical binding]; other site 941639005765 Walker B motif; other site 941639005766 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 941639005767 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 941639005768 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 941639005769 ATP cone domain; Region: ATP-cone; pfam03477 941639005770 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 941639005771 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 941639005772 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941639005773 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 941639005774 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 941639005775 CoA-binding site [chemical binding]; other site 941639005776 ATP-binding [chemical binding]; other site 941639005777 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 941639005778 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 941639005779 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 941639005780 DNA binding site [nucleotide binding] 941639005781 catalytic residue [active] 941639005782 H2TH interface [polypeptide binding]; other site 941639005783 putative catalytic residues [active] 941639005784 turnover-facilitating residue; other site 941639005785 intercalation triad [nucleotide binding]; other site 941639005786 8OG recognition residue [nucleotide binding]; other site 941639005787 putative reading head residues; other site 941639005788 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 941639005789 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 941639005790 DNA polymerase I; Provisional; Region: PRK05755 941639005791 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 941639005792 active site 941639005793 metal binding site 1 [ion binding]; metal-binding site 941639005794 putative 5' ssDNA interaction site; other site 941639005795 metal binding site 3; metal-binding site 941639005796 metal binding site 2 [ion binding]; metal-binding site 941639005797 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 941639005798 putative DNA binding site [nucleotide binding]; other site 941639005799 putative metal binding site [ion binding]; other site 941639005800 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 941639005801 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 941639005802 active site 941639005803 DNA binding site [nucleotide binding] 941639005804 catalytic site [active] 941639005805 malate dehydrogenase; Reviewed; Region: PRK06223 941639005806 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 941639005807 NAD(P) binding site [chemical binding]; other site 941639005808 dimer interface [polypeptide binding]; other site 941639005809 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941639005810 substrate binding site [chemical binding]; other site 941639005811 isocitrate dehydrogenase; Reviewed; Region: PRK07006 941639005812 isocitrate dehydrogenase; Validated; Region: PRK07362 941639005813 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 941639005814 dimer interface [polypeptide binding]; other site 941639005815 Citrate synthase; Region: Citrate_synt; pfam00285 941639005816 active site 941639005817 citrylCoA binding site [chemical binding]; other site 941639005818 oxalacetate/citrate binding site [chemical binding]; other site 941639005819 coenzyme A binding site [chemical binding]; other site 941639005820 catalytic triad [active] 941639005821 Protein of unknown function (DUF441); Region: DUF441; pfam04284 941639005822 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 941639005823 Domain of unknown function DUF20; Region: UPF0118; pfam01594 941639005824 pyruvate kinase; Provisional; Region: PRK06354 941639005825 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 941639005826 domain interfaces; other site 941639005827 active site 941639005828 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 941639005829 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 941639005830 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 941639005831 active site 941639005832 ADP/pyrophosphate binding site [chemical binding]; other site 941639005833 dimerization interface [polypeptide binding]; other site 941639005834 allosteric effector site; other site 941639005835 fructose-1,6-bisphosphate binding site; other site 941639005836 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 941639005837 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 941639005838 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 941639005839 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 941639005840 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 941639005841 Malic enzyme, N-terminal domain; Region: malic; pfam00390 941639005842 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 941639005843 putative NAD(P) binding site [chemical binding]; other site 941639005844 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 941639005845 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 941639005846 active site 941639005847 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 941639005848 generic binding surface II; other site 941639005849 generic binding surface I; other site 941639005850 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 941639005851 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 941639005852 DHH family; Region: DHH; pfam01368 941639005853 DHHA1 domain; Region: DHHA1; pfam02272 941639005854 YtpI-like protein; Region: YtpI; pfam14007 941639005855 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 941639005856 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639005857 DNA-binding site [nucleotide binding]; DNA binding site 941639005858 DRTGG domain; Region: DRTGG; pfam07085 941639005859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 941639005860 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 941639005861 active site 2 [active] 941639005862 active site 1 [active] 941639005863 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 941639005864 metal-dependent hydrolase; Provisional; Region: PRK00685 941639005865 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941639005866 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941639005867 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 941639005868 active site 941639005869 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 941639005870 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 941639005871 hexamer interface [polypeptide binding]; other site 941639005872 ligand binding site [chemical binding]; other site 941639005873 putative active site [active] 941639005874 NAD(P) binding site [chemical binding]; other site 941639005875 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941639005876 Ligand Binding Site [chemical binding]; other site 941639005877 EcsC protein family; Region: EcsC; pfam12787 941639005878 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 941639005879 propionate/acetate kinase; Provisional; Region: PRK12379 941639005880 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 941639005881 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639005882 S-adenosylmethionine binding site [chemical binding]; other site 941639005883 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 941639005884 dimer interface [polypeptide binding]; other site 941639005885 catalytic triad [active] 941639005886 peroxidatic and resolving cysteines [active] 941639005887 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 941639005888 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 941639005889 RDD family; Region: RDD; pfam06271 941639005890 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 941639005891 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 941639005892 tandem repeat interface [polypeptide binding]; other site 941639005893 oligomer interface [polypeptide binding]; other site 941639005894 active site residues [active] 941639005895 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 941639005896 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 941639005897 active site 941639005898 acyl-activating enzyme (AAE) consensus motif; other site 941639005899 putative CoA binding site [chemical binding]; other site 941639005900 AMP binding site [chemical binding]; other site 941639005901 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 941639005902 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 941639005903 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 941639005904 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 941639005905 Ligand Binding Site [chemical binding]; other site 941639005906 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 941639005907 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 941639005908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941639005909 catalytic residue [active] 941639005910 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 941639005911 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941639005912 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941639005913 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 941639005914 GAF domain; Region: GAF_3; pfam13492 941639005915 GAF domain; Region: GAF_2; pfam13185 941639005916 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 941639005917 GAF domain; Region: GAF; cl17456 941639005918 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 941639005919 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 941639005920 metal binding site [ion binding]; metal-binding site 941639005921 active site 941639005922 I-site; other site 941639005923 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 941639005924 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 941639005925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639005926 RNA binding surface [nucleotide binding]; other site 941639005927 Proline dehydrogenase; Region: Pro_dh; cl03282 941639005928 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 941639005929 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 941639005930 Glutamate binding site [chemical binding]; other site 941639005931 homodimer interface [polypeptide binding]; other site 941639005932 NAD binding site [chemical binding]; other site 941639005933 catalytic residues [active] 941639005934 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639005935 PAS domain; Region: PAS_9; pfam13426 941639005936 putative active site [active] 941639005937 heme pocket [chemical binding]; other site 941639005938 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 941639005939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639005940 Walker A motif; other site 941639005941 ATP binding site [chemical binding]; other site 941639005942 Walker B motif; other site 941639005943 arginine finger; other site 941639005944 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 941639005945 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 941639005946 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 941639005947 active site 941639005948 HIGH motif; other site 941639005949 dimer interface [polypeptide binding]; other site 941639005950 KMSKS motif; other site 941639005951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639005952 RNA binding surface [nucleotide binding]; other site 941639005953 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 941639005954 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 941639005955 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941639005956 catalytic loop [active] 941639005957 iron binding site [ion binding]; other site 941639005958 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 941639005959 4Fe-4S binding domain; Region: Fer4; pfam00037 941639005960 4Fe-4S binding domain; Region: Fer4; pfam00037 941639005961 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 941639005962 [4Fe-4S] binding site [ion binding]; other site 941639005963 molybdopterin cofactor binding site; other site 941639005964 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 941639005965 molybdopterin cofactor binding site; other site 941639005966 Uncharacterized conserved protein [Function unknown]; Region: COG2427 941639005967 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 941639005968 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 941639005969 ATP binding site [chemical binding]; other site 941639005970 substrate interface [chemical binding]; other site 941639005971 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 941639005972 trimer interface [polypeptide binding]; other site 941639005973 dimer interface [polypeptide binding]; other site 941639005974 putative active site [active] 941639005975 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 941639005976 MoaE interaction surface [polypeptide binding]; other site 941639005977 MoeB interaction surface [polypeptide binding]; other site 941639005978 thiocarboxylated glycine; other site 941639005979 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 941639005980 MoaE homodimer interface [polypeptide binding]; other site 941639005981 MoaD interaction [polypeptide binding]; other site 941639005982 active site residues [active] 941639005983 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 941639005984 Walker A motif; other site 941639005985 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 941639005986 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 941639005987 dimer interface [polypeptide binding]; other site 941639005988 putative functional site; other site 941639005989 putative MPT binding site; other site 941639005990 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 941639005991 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 941639005992 GTP binding site; other site 941639005993 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 941639005994 MPT binding site; other site 941639005995 trimer interface [polypeptide binding]; other site 941639005996 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 941639005997 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639005998 FeS/SAM binding site; other site 941639005999 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 941639006000 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639006001 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 941639006002 Walker A/P-loop; other site 941639006003 ATP binding site [chemical binding]; other site 941639006004 Q-loop/lid; other site 941639006005 ABC transporter signature motif; other site 941639006006 Walker B; other site 941639006007 D-loop; other site 941639006008 H-loop/switch region; other site 941639006009 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 941639006010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639006011 dimer interface [polypeptide binding]; other site 941639006012 conserved gate region; other site 941639006013 putative PBP binding loops; other site 941639006014 ABC-ATPase subunit interface; other site 941639006015 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 941639006016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639006017 substrate binding pocket [chemical binding]; other site 941639006018 membrane-bound complex binding site; other site 941639006019 hinge residues; other site 941639006020 acetyl-CoA synthetase; Provisional; Region: PRK04319 941639006021 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 941639006022 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 941639006023 active site 941639006024 acyl-activating enzyme (AAE) consensus motif; other site 941639006025 putative CoA binding site [chemical binding]; other site 941639006026 AMP binding site [chemical binding]; other site 941639006027 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639006028 Coenzyme A binding pocket [chemical binding]; other site 941639006029 FOG: CBS domain [General function prediction only]; Region: COG0517 941639006030 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 941639006031 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 941639006032 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 941639006033 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 941639006034 active site 941639006035 Zn binding site [ion binding]; other site 941639006036 catabolite control protein A; Region: ccpA; TIGR01481 941639006037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639006038 DNA binding site [nucleotide binding] 941639006039 domain linker motif; other site 941639006040 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 941639006041 dimerization interface [polypeptide binding]; other site 941639006042 effector binding site; other site 941639006043 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 941639006044 Chorismate mutase type II; Region: CM_2; cl00693 941639006045 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 941639006046 YtxH-like protein; Region: YtxH; pfam12732 941639006047 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 941639006048 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 941639006049 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941639006050 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941639006051 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941639006052 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 941639006053 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 941639006054 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 941639006055 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 941639006056 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 941639006057 putative tRNA-binding site [nucleotide binding]; other site 941639006058 hypothetical protein; Provisional; Region: PRK13668 941639006059 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941639006060 catalytic residues [active] 941639006061 Response regulator receiver domain; Region: Response_reg; pfam00072 941639006062 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639006063 active site 941639006064 phosphorylation site [posttranslational modification] 941639006065 intermolecular recognition site; other site 941639006066 dimerization interface [polypeptide binding]; other site 941639006067 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941639006068 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 941639006069 HAMP domain; Region: HAMP; pfam00672 941639006070 Predicted small secreted protein [Function unknown]; Region: COG5584 941639006071 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 941639006072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639006073 S-adenosylmethionine binding site [chemical binding]; other site 941639006074 YtzH-like protein; Region: YtzH; pfam14165 941639006075 Phosphotransferase enzyme family; Region: APH; pfam01636 941639006076 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 941639006077 active site 941639006078 substrate binding site [chemical binding]; other site 941639006079 ATP binding site [chemical binding]; other site 941639006080 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 941639006081 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941639006082 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 941639006083 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 941639006084 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 941639006085 homodimer interface [polypeptide binding]; other site 941639006086 substrate-cofactor binding pocket; other site 941639006087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639006088 catalytic residue [active] 941639006089 dipeptidase PepV; Reviewed; Region: PRK07318 941639006090 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 941639006091 active site 941639006092 metal binding site [ion binding]; metal-binding site 941639006093 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 941639006094 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 941639006095 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 941639006096 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 941639006097 HIGH motif; other site 941639006098 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 941639006099 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 941639006100 active site 941639006101 KMSKS motif; other site 941639006102 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 941639006103 tRNA binding surface [nucleotide binding]; other site 941639006104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639006105 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639006106 putative substrate translocation pore; other site 941639006107 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 941639006108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 941639006109 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 941639006110 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 941639006111 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 941639006112 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941639006113 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 941639006114 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 941639006115 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 941639006116 trimer interface [polypeptide binding]; other site 941639006117 putative metal binding site [ion binding]; other site 941639006118 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 941639006119 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941639006120 dimer interface [polypeptide binding]; other site 941639006121 active site 941639006122 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941639006123 Ligand Binding Site [chemical binding]; other site 941639006124 Molecular Tunnel; other site 941639006125 S-adenosylmethionine synthetase; Validated; Region: PRK05250 941639006126 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 941639006127 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 941639006128 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 941639006129 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 941639006130 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 941639006131 active site 941639006132 substrate-binding site [chemical binding]; other site 941639006133 metal-binding site [ion binding] 941639006134 ATP binding site [chemical binding]; other site 941639006135 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 941639006136 nudix motif; other site 941639006137 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 941639006138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 941639006139 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 941639006140 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 941639006141 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941639006142 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 941639006143 N- and C-terminal domain interface [polypeptide binding]; other site 941639006144 active site 941639006145 catalytic site [active] 941639006146 metal binding site [ion binding]; metal-binding site 941639006147 carbohydrate binding site [chemical binding]; other site 941639006148 ATP binding site [chemical binding]; other site 941639006149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941639006150 NMT1-like family; Region: NMT1_2; pfam13379 941639006151 NMT1/THI5 like; Region: NMT1; pfam09084 941639006152 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941639006153 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941639006154 Walker A/P-loop; other site 941639006155 ATP binding site [chemical binding]; other site 941639006156 Q-loop/lid; other site 941639006157 ABC transporter signature motif; other site 941639006158 Walker B; other site 941639006159 D-loop; other site 941639006160 H-loop/switch region; other site 941639006161 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941639006162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639006163 dimer interface [polypeptide binding]; other site 941639006164 conserved gate region; other site 941639006165 putative PBP binding loops; other site 941639006166 ABC-ATPase subunit interface; other site 941639006167 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 941639006168 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 941639006169 nudix motif; other site 941639006170 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 941639006171 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 941639006172 dimerization interface [polypeptide binding]; other site 941639006173 DPS ferroxidase diiron center [ion binding]; other site 941639006174 ion pore; other site 941639006175 hypothetical protein; Validated; Region: PRK00041 941639006176 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 941639006177 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941639006178 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 941639006179 intersubunit interface [polypeptide binding]; other site 941639006180 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 941639006181 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 941639006182 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 941639006183 active site 941639006184 octamer interface [polypeptide binding]; other site 941639006185 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 941639006186 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 941639006187 acyl-activating enzyme (AAE) consensus motif; other site 941639006188 putative AMP binding site [chemical binding]; other site 941639006189 putative active site [active] 941639006190 putative CoA binding site [chemical binding]; other site 941639006191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941639006192 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 941639006193 substrate binding site [chemical binding]; other site 941639006194 oxyanion hole (OAH) forming residues; other site 941639006195 trimer interface [polypeptide binding]; other site 941639006196 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 941639006197 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 941639006198 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 941639006199 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 941639006200 dimer interface [polypeptide binding]; other site 941639006201 tetramer interface [polypeptide binding]; other site 941639006202 PYR/PP interface [polypeptide binding]; other site 941639006203 TPP binding site [chemical binding]; other site 941639006204 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941639006205 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 941639006206 TPP-binding site; other site 941639006207 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 941639006208 chorismate binding enzyme; Region: Chorismate_bind; cl10555 941639006209 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 941639006210 UbiA prenyltransferase family; Region: UbiA; pfam01040 941639006211 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941639006212 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 941639006213 EamA-like transporter family; Region: EamA; pfam00892 941639006214 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 941639006215 EamA-like transporter family; Region: EamA; pfam00892 941639006216 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 941639006217 MgtC family; Region: MgtC; pfam02308 941639006218 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 941639006219 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941639006220 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639006221 metal-binding site [ion binding] 941639006222 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941639006223 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639006224 metal-binding site [ion binding] 941639006225 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941639006226 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941639006227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941639006228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639006229 metal-binding site [ion binding] 941639006230 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 941639006231 putative homodimer interface [polypeptide binding]; other site 941639006232 putative homotetramer interface [polypeptide binding]; other site 941639006233 allosteric switch controlling residues; other site 941639006234 putative metal binding site [ion binding]; other site 941639006235 putative homodimer-homodimer interface [polypeptide binding]; other site 941639006236 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 941639006237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941639006238 putative DNA binding site [nucleotide binding]; other site 941639006239 putative Zn2+ binding site [ion binding]; other site 941639006240 AsnC family; Region: AsnC_trans_reg; pfam01037 941639006241 Uncharacterized conserved protein [Function unknown]; Region: COG2128 941639006242 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941639006243 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 941639006244 metal binding site [ion binding]; metal-binding site 941639006245 dimer interface [polypeptide binding]; other site 941639006246 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 941639006247 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 941639006248 Na binding site [ion binding]; other site 941639006249 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 941639006250 dimerization interface [polypeptide binding]; other site 941639006251 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 941639006252 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941639006253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639006254 dimerization interface [polypeptide binding]; other site 941639006255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639006256 dimer interface [polypeptide binding]; other site 941639006257 phosphorylation site [posttranslational modification] 941639006258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639006259 ATP binding site [chemical binding]; other site 941639006260 Mg2+ binding site [ion binding]; other site 941639006261 G-X-G motif; other site 941639006262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639006263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639006264 active site 941639006265 phosphorylation site [posttranslational modification] 941639006266 intermolecular recognition site; other site 941639006267 dimerization interface [polypeptide binding]; other site 941639006268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639006269 DNA binding site [nucleotide binding] 941639006270 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 941639006271 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 941639006272 classical (c) SDRs; Region: SDR_c; cd05233 941639006273 active site 941639006274 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 941639006275 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941639006276 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 941639006277 NodB motif; other site 941639006278 active site 941639006279 catalytic site [active] 941639006280 Zn binding site [ion binding]; other site 941639006281 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 941639006282 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 941639006283 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 941639006284 Cl- selectivity filter; other site 941639006285 Cl- binding residues [ion binding]; other site 941639006286 pore gating glutamate residue; other site 941639006287 dimer interface [polypeptide binding]; other site 941639006288 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 941639006289 active site residue [active] 941639006290 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 941639006291 putative homodimer interface [polypeptide binding]; other site 941639006292 putative homotetramer interface [polypeptide binding]; other site 941639006293 putative allosteric switch controlling residues; other site 941639006294 putative metal binding site [ion binding]; other site 941639006295 putative homodimer-homodimer interface [polypeptide binding]; other site 941639006296 Staphylococcal nuclease homologues; Region: SNc; smart00318 941639006297 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 941639006298 Catalytic site; other site 941639006299 Excalibur calcium-binding domain; Region: Excalibur; smart00894 941639006300 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941639006301 HPr interaction site; other site 941639006302 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941639006303 active site 941639006304 phosphorylation site [posttranslational modification] 941639006305 L-arabinose isomerase; Provisional; Region: PRK02929 941639006306 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 941639006307 hexamer (dimer of trimers) interface [polypeptide binding]; other site 941639006308 trimer interface [polypeptide binding]; other site 941639006309 substrate binding site [chemical binding]; other site 941639006310 Mn binding site [ion binding]; other site 941639006311 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 941639006312 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 941639006313 intersubunit interface [polypeptide binding]; other site 941639006314 active site 941639006315 Zn2+ binding site [ion binding]; other site 941639006316 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 941639006317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639006318 putative substrate translocation pore; other site 941639006319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639006320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 941639006321 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 941639006322 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639006323 DNA-binding site [nucleotide binding]; DNA binding site 941639006324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941639006325 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 941639006326 putative dimerization interface [polypeptide binding]; other site 941639006327 putative ligand binding site [chemical binding]; other site 941639006328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639006329 dimerization interface [polypeptide binding]; other site 941639006330 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639006331 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639006332 dimer interface [polypeptide binding]; other site 941639006333 putative CheW interface [polypeptide binding]; other site 941639006334 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 941639006335 putative acyl-acceptor binding pocket; other site 941639006336 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 941639006337 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 941639006338 Ligand binding site; other site 941639006339 Putative Catalytic site; other site 941639006340 DXD motif; other site 941639006341 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 941639006342 classical (c) SDRs; Region: SDR_c; cd05233 941639006343 NAD(P) binding site [chemical binding]; other site 941639006344 active site 941639006345 Divergent PAP2 family; Region: DUF212; cl00855 941639006346 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 941639006347 hydroxyglutarate oxidase; Provisional; Region: PRK11728 941639006348 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941639006349 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 941639006350 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 941639006351 NAD(P) binding site [chemical binding]; other site 941639006352 catalytic residues [active] 941639006353 ornithine cyclodeaminase; Validated; Region: PRK08618 941639006354 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 941639006355 Ion channel; Region: Ion_trans_2; pfam07885 941639006356 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 941639006357 TrkA-N domain; Region: TrkA_N; pfam02254 941639006358 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 941639006359 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 941639006360 active site 941639006361 dimer interface [polypeptide binding]; other site 941639006362 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 941639006363 dimer interface [polypeptide binding]; other site 941639006364 active site 941639006365 Uncharacterized conserved protein [Function unknown]; Region: COG2155 941639006366 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 941639006367 general stress protein 13; Validated; Region: PRK08059 941639006368 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 941639006369 RNA binding site [nucleotide binding]; other site 941639006370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639006371 non-specific DNA binding site [nucleotide binding]; other site 941639006372 salt bridge; other site 941639006373 sequence-specific DNA binding site [nucleotide binding]; other site 941639006374 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 941639006375 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 941639006376 active site 941639006377 FMN binding site [chemical binding]; other site 941639006378 substrate binding site [chemical binding]; other site 941639006379 homotetramer interface [polypeptide binding]; other site 941639006380 catalytic residue [active] 941639006381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639006382 active site 941639006383 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639006384 catalytic tetrad [active] 941639006385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639006386 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639006387 active site 941639006388 catalytic tetrad [active] 941639006389 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 941639006390 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 941639006391 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 941639006392 active site 941639006393 Kinase associated protein B; Region: KapB; pfam08810 941639006394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639006395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639006396 putative substrate translocation pore; other site 941639006397 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 941639006398 CoenzymeA binding site [chemical binding]; other site 941639006399 subunit interaction site [polypeptide binding]; other site 941639006400 PHB binding site; other site 941639006401 Spore germination protein; Region: Spore_permease; pfam03845 941639006402 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 941639006403 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 941639006404 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 941639006405 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 941639006406 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 941639006407 interface (dimer of trimers) [polypeptide binding]; other site 941639006408 Substrate-binding/catalytic site; other site 941639006409 Zn-binding sites [ion binding]; other site 941639006410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 941639006411 Putative membrane protein; Region: YuiB; pfam14068 941639006412 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 941639006413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639006414 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 941639006415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639006416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 941639006417 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 941639006418 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 941639006419 NifU-like domain; Region: NifU; pfam01106 941639006420 spore coat protein YutH; Region: spore_yutH; TIGR02905 941639006421 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 941639006422 tetramer interfaces [polypeptide binding]; other site 941639006423 binuclear metal-binding site [ion binding]; other site 941639006424 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 941639006425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639006426 active site 941639006427 motif I; other site 941639006428 motif II; other site 941639006429 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639006430 Uncharacterized conserved protein [Function unknown]; Region: COG2445 941639006431 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 941639006432 lipoyl synthase; Provisional; Region: PRK05481 941639006433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639006434 FeS/SAM binding site; other site 941639006435 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941639006436 Peptidase family M23; Region: Peptidase_M23; pfam01551 941639006437 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; pfam09560 941639006438 Uncharacterized conserved protein [Function unknown]; Region: COG3377 941639006439 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 941639006440 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 941639006441 active site 941639006442 metal binding site [ion binding]; metal-binding site 941639006443 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 941639006444 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 941639006445 FeS assembly protein SufB; Region: sufB; TIGR01980 941639006446 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 941639006447 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 941639006448 active site 941639006449 trimerization site [polypeptide binding]; other site 941639006450 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 941639006451 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 941639006452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941639006453 catalytic residue [active] 941639006454 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 941639006455 FeS assembly protein SufD; Region: sufD; TIGR01981 941639006456 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 941639006457 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 941639006458 Walker A/P-loop; other site 941639006459 ATP binding site [chemical binding]; other site 941639006460 Q-loop/lid; other site 941639006461 ABC transporter signature motif; other site 941639006462 Walker B; other site 941639006463 D-loop; other site 941639006464 H-loop/switch region; other site 941639006465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941639006466 catalytic residues [active] 941639006467 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 941639006468 lipoyl attachment site [posttranslational modification]; other site 941639006469 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 941639006470 ArsC family; Region: ArsC; pfam03960 941639006471 putative ArsC-like catalytic residues; other site 941639006472 putative TRX-like catalytic residues [active] 941639006473 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 941639006474 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941639006475 active site 941639006476 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 941639006477 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941639006478 dimer interface [polypeptide binding]; other site 941639006479 active site 941639006480 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 941639006481 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941639006482 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941639006483 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 941639006484 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 941639006485 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 941639006486 substrate binding site [chemical binding]; other site 941639006487 oxyanion hole (OAH) forming residues; other site 941639006488 trimer interface [polypeptide binding]; other site 941639006489 YuzL-like protein; Region: YuzL; pfam14115 941639006490 Coat F domain; Region: Coat_F; pfam07875 941639006491 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 941639006492 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941639006493 catalytic residues [active] 941639006494 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 941639006495 putative active site [active] 941639006496 putative catalytic site [active] 941639006497 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 941639006498 PLD-like domain; Region: PLDc_2; pfam13091 941639006499 putative active site [active] 941639006500 putative catalytic site [active] 941639006501 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 941639006502 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 941639006503 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 941639006504 putative active site [active] 941639006505 putative NTP binding site [chemical binding]; other site 941639006506 putative nucleic acid binding site [nucleotide binding]; other site 941639006507 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 941639006508 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 941639006509 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 941639006510 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 941639006511 tetramer interface [polypeptide binding]; other site 941639006512 heme binding pocket [chemical binding]; other site 941639006513 NADPH binding site [chemical binding]; other site 941639006514 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 941639006515 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 941639006516 active site 941639006517 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 941639006518 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 941639006519 NodB motif; other site 941639006520 putative active site [active] 941639006521 putative catalytic site [active] 941639006522 putative Zn binding site [ion binding]; other site 941639006523 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 941639006524 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 941639006525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941639006526 Putative zinc-finger; Region: zf-HC2; pfam13490 941639006527 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 941639006528 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639006529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639006530 DNA binding residues [nucleotide binding] 941639006531 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 941639006532 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941639006533 conserved hypothetical integral membrane protein; Region: TIGR03766 941639006534 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941639006535 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639006536 ABC transporter; Region: ABC_tran_2; pfam12848 941639006537 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639006538 ABC transporter; Region: ABC_tran; pfam00005 941639006539 Homeodomain-like domain; Region: HTH_23; pfam13384 941639006540 Winged helix-turn helix; Region: HTH_29; pfam13551 941639006541 Homeodomain-like domain; Region: HTH_32; pfam13565 941639006542 Winged helix-turn helix; Region: HTH_33; pfam13592 941639006543 DDE superfamily endonuclease; Region: DDE_3; pfam13358 941639006544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 941639006545 Probable transposase; Region: OrfB_IS605; pfam01385 941639006546 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639006547 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 941639006548 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 941639006549 SmpB-tmRNA interface; other site 941639006550 ribonuclease R; Region: RNase_R; TIGR02063 941639006551 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 941639006552 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 941639006553 RNB domain; Region: RNB; pfam00773 941639006554 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 941639006555 RNA binding site [nucleotide binding]; other site 941639006556 Esterase/lipase [General function prediction only]; Region: COG1647 941639006557 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 941639006558 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 941639006559 enolase; Provisional; Region: eno; PRK00077 941639006560 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 941639006561 dimer interface [polypeptide binding]; other site 941639006562 metal binding site [ion binding]; metal-binding site 941639006563 substrate binding pocket [chemical binding]; other site 941639006564 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 941639006565 phosphoglyceromutase; Provisional; Region: PRK05434 941639006566 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 941639006567 triosephosphate isomerase; Provisional; Region: PRK14565 941639006568 substrate binding site [chemical binding]; other site 941639006569 dimer interface [polypeptide binding]; other site 941639006570 catalytic triad [active] 941639006571 Phosphoglycerate kinase; Region: PGK; pfam00162 941639006572 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 941639006573 substrate binding site [chemical binding]; other site 941639006574 hinge regions; other site 941639006575 ADP binding site [chemical binding]; other site 941639006576 catalytic site [active] 941639006577 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 941639006578 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 941639006579 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 941639006580 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941639006581 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941639006582 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 941639006583 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 941639006584 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 941639006585 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 941639006586 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 941639006587 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639006588 metal-binding site [ion binding] 941639006589 Uncharacterized conserved protein [Function unknown]; Region: COG2427 941639006590 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 941639006591 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 941639006592 catalytic loop [active] 941639006593 iron binding site [ion binding]; other site 941639006594 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 941639006595 4Fe-4S binding domain; Region: Fer4; pfam00037 941639006596 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 941639006597 [4Fe-4S] binding site [ion binding]; other site 941639006598 molybdopterin cofactor binding site; other site 941639006599 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 941639006600 molybdopterin cofactor binding site; other site 941639006601 PCI domain; Region: PCI; cl02111 941639006602 Transglycosylase; Region: Transgly; pfam00912 941639006603 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 941639006604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941639006605 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 941639006606 Ligand Binding Site [chemical binding]; other site 941639006607 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 941639006608 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941639006609 Walker A/P-loop; other site 941639006610 ATP binding site [chemical binding]; other site 941639006611 Q-loop/lid; other site 941639006612 ABC transporter signature motif; other site 941639006613 Walker B; other site 941639006614 D-loop; other site 941639006615 H-loop/switch region; other site 941639006616 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941639006617 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941639006618 NlpC/P60 family; Region: NLPC_P60; pfam00877 941639006619 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 941639006620 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 941639006621 peptide binding site [polypeptide binding]; other site 941639006622 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 941639006623 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 941639006624 Walker A/P-loop; other site 941639006625 ATP binding site [chemical binding]; other site 941639006626 Q-loop/lid; other site 941639006627 ABC transporter signature motif; other site 941639006628 Walker B; other site 941639006629 D-loop; other site 941639006630 H-loop/switch region; other site 941639006631 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 941639006632 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 941639006633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639006634 dimer interface [polypeptide binding]; other site 941639006635 conserved gate region; other site 941639006636 putative PBP binding loops; other site 941639006637 ABC-ATPase subunit interface; other site 941639006638 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 941639006639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639006640 dimer interface [polypeptide binding]; other site 941639006641 conserved gate region; other site 941639006642 putative PBP binding loops; other site 941639006643 ABC-ATPase subunit interface; other site 941639006644 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 941639006645 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 941639006646 catalytic triad [active] 941639006647 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 941639006648 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 941639006649 oligomer interface [polypeptide binding]; other site 941639006650 metal binding site [ion binding]; metal-binding site 941639006651 metal binding site [ion binding]; metal-binding site 941639006652 putative Cl binding site [ion binding]; other site 941639006653 aspartate ring; other site 941639006654 basic sphincter; other site 941639006655 hydrophobic gate; other site 941639006656 periplasmic entrance; other site 941639006657 YhdB-like protein; Region: YhdB; pfam14148 941639006658 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 941639006659 SpoVR like protein; Region: SpoVR; pfam04293 941639006660 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 941639006661 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 941639006662 active site 941639006663 catalytic triad [active] 941639006664 oxyanion hole [active] 941639006665 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 941639006666 catalytic residues [active] 941639006667 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 941639006668 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 941639006669 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 941639006670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639006671 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 941639006672 Transposase; Region: DEDD_Tnp_IS110; pfam01548 941639006673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 941639006674 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 941639006675 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 941639006676 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 941639006677 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 941639006678 Putative amidase domain; Region: Amidase_6; pfam12671 941639006679 epoxyqueuosine reductase; Region: TIGR00276 941639006680 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 941639006681 4Fe-4S binding domain; Region: Fer4; cl02805 941639006682 HEAT repeats; Region: HEAT_2; pfam13646 941639006683 MarC family integral membrane protein; Region: MarC; pfam01914 941639006684 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 941639006685 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 941639006686 DHHA2 domain; Region: DHHA2; pfam02833 941639006687 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 941639006688 Uncharacterized conserved protein [Function unknown]; Region: COG1633 941639006689 dinuclear metal binding motif [ion binding]; other site 941639006690 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941639006691 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639006692 substrate binding pocket [chemical binding]; other site 941639006693 membrane-bound complex binding site; other site 941639006694 hinge residues; other site 941639006695 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941639006696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639006697 dimer interface [polypeptide binding]; other site 941639006698 conserved gate region; other site 941639006699 putative PBP binding loops; other site 941639006700 ABC-ATPase subunit interface; other site 941639006701 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941639006702 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 941639006703 Walker A/P-loop; other site 941639006704 ATP binding site [chemical binding]; other site 941639006705 Q-loop/lid; other site 941639006706 ABC transporter signature motif; other site 941639006707 Walker B; other site 941639006708 D-loop; other site 941639006709 H-loop/switch region; other site 941639006710 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 941639006711 Protein of unknown function (DUF2705); Region: DUF2705; pfam10920 941639006712 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 941639006713 Pyruvate formate lyase 1; Region: PFL1; cd01678 941639006714 coenzyme A binding site [chemical binding]; other site 941639006715 active site 941639006716 catalytic residues [active] 941639006717 glycine loop; other site 941639006718 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 941639006719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639006720 FeS/SAM binding site; other site 941639006721 Predicted flavoprotein [General function prediction only]; Region: COG0431 941639006722 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941639006723 hypothetical protein; Provisional; Region: PRK06770 941639006724 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 941639006725 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 941639006726 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 941639006727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639006728 Walker A/P-loop; other site 941639006729 ATP binding site [chemical binding]; other site 941639006730 Q-loop/lid; other site 941639006731 ABC transporter signature motif; other site 941639006732 Walker B; other site 941639006733 D-loop; other site 941639006734 H-loop/switch region; other site 941639006735 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 941639006736 active site 941639006737 catalytic triad [active] 941639006738 oxyanion hole [active] 941639006739 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 941639006740 Protein of unknown function DUF91; Region: DUF91; cl00709 941639006741 Uncharacterized conserved protein [Function unknown]; Region: COG3586 941639006742 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 941639006743 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 941639006744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 941639006745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 941639006746 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 941639006747 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 941639006748 NAD(P) binding site [chemical binding]; other site 941639006749 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 941639006750 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 941639006751 acetolactate synthase; Reviewed; Region: PRK08617 941639006752 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941639006753 PYR/PP interface [polypeptide binding]; other site 941639006754 dimer interface [polypeptide binding]; other site 941639006755 TPP binding site [chemical binding]; other site 941639006756 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941639006757 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 941639006758 TPP-binding site [chemical binding]; other site 941639006759 dimer interface [polypeptide binding]; other site 941639006760 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 941639006761 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941639006762 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941639006763 dimerization interface [polypeptide binding]; other site 941639006764 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 941639006765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 941639006766 ligand binding site [chemical binding]; other site 941639006767 flexible hinge region; other site 941639006768 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 941639006769 putative switch regulator; other site 941639006770 non-specific DNA interactions [nucleotide binding]; other site 941639006771 DNA binding site [nucleotide binding] 941639006772 sequence specific DNA binding site [nucleotide binding]; other site 941639006773 putative cAMP binding site [chemical binding]; other site 941639006774 Amidinotransferase; Region: Amidinotransf; cl12043 941639006775 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 941639006776 metal binding site 2 [ion binding]; metal-binding site 941639006777 metal binding site 1 [ion binding]; metal-binding site 941639006778 dimer interface [polypeptide binding]; other site 941639006779 structural Zn2+ binding site [ion binding]; other site 941639006780 potential frameshift: common BLAST hit: gi|239828605|ref|YP_002951229.1| transposase IS4 family protein 941639006781 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 941639006782 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 941639006783 Ion channel; Region: Ion_trans_2; pfam07885 941639006784 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 941639006785 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941639006786 inhibitor-cofactor binding pocket; inhibition site 941639006787 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639006788 catalytic residue [active] 941639006789 potential frameshift: common BLAST hit: gi|321314825|ref|YP_004207112.1| putative efflux transporter 941639006790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639006791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639006792 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 941639006793 Predicted membrane protein [Function unknown]; Region: COG4129 941639006794 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 941639006795 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941639006796 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941639006797 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941639006798 putative active site [active] 941639006799 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 941639006800 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941639006801 active site turn [active] 941639006802 phosphorylation site [posttranslational modification] 941639006803 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941639006804 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 941639006805 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 941639006806 putative active site [active] 941639006807 Uncharacterized conserved protein [Function unknown]; Region: COG3589 941639006808 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 941639006809 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639006810 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639006811 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 941639006812 Walker A/P-loop; other site 941639006813 ATP binding site [chemical binding]; other site 941639006814 Q-loop/lid; other site 941639006815 ABC transporter signature motif; other site 941639006816 Walker B; other site 941639006817 D-loop; other site 941639006818 H-loop/switch region; other site 941639006819 Protein of unknown function (DUF402); Region: DUF402; cl00979 941639006820 YgaB-like protein; Region: YgaB; pfam14182 941639006821 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 941639006822 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 941639006823 putative NAD(P) binding site [chemical binding]; other site 941639006824 active site 941639006825 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941639006826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941639006827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941639006828 dimerization interface [polypeptide binding]; other site 941639006829 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 941639006830 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 941639006831 active site 941639006832 dimer interface [polypeptide binding]; other site 941639006833 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 941639006834 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 941639006835 active site 941639006836 FMN binding site [chemical binding]; other site 941639006837 substrate binding site [chemical binding]; other site 941639006838 3Fe-4S cluster binding site [ion binding]; other site 941639006839 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 941639006840 domain interface; other site 941639006841 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 941639006842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 941639006843 Transposase domain (DUF772); Region: DUF772; pfam05598 941639006844 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 941639006845 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639006846 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 941639006847 Small acid-soluble spore protein K family; Region: SspK; pfam08176 941639006848 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 941639006849 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 941639006850 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941639006851 helix-hairpin-helix signature motif; other site 941639006852 substrate binding pocket [chemical binding]; other site 941639006853 active site 941639006854 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 941639006855 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 941639006856 DNA binding and oxoG recognition site [nucleotide binding] 941639006857 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 941639006858 recombination regulator RecX; Provisional; Region: recX; PRK14135 941639006859 YfhD-like protein; Region: YfhD; pfam14151 941639006860 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 941639006861 substrate binding site [chemical binding]; other site 941639006862 active site 941639006863 catalytic residues [active] 941639006864 heterodimer interface [polypeptide binding]; other site 941639006865 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 941639006866 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 941639006867 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 941639006868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639006869 catalytic residue [active] 941639006870 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 941639006871 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 941639006872 active site 941639006873 ribulose/triose binding site [chemical binding]; other site 941639006874 phosphate binding site [ion binding]; other site 941639006875 substrate (anthranilate) binding pocket [chemical binding]; other site 941639006876 product (indole) binding pocket [chemical binding]; other site 941639006877 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 941639006878 active site 941639006879 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 941639006880 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 941639006881 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 941639006882 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 941639006883 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 941639006884 glutamine binding [chemical binding]; other site 941639006885 catalytic triad [active] 941639006886 anthranilate synthase component I; Provisional; Region: PRK13570 941639006887 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 941639006888 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 941639006889 potential frameshift: common BLAST hit: gi|328958028|ref|YP_004375414.1| glycogen phosphorylase 941639006890 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941639006891 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 941639006892 Cache domain; Region: Cache_1; pfam02743 941639006893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639006894 dimerization interface [polypeptide binding]; other site 941639006895 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639006896 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639006897 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639006898 dimer interface [polypeptide binding]; other site 941639006899 putative CheW interface [polypeptide binding]; other site 941639006900 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 941639006901 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 941639006902 NAD binding site [chemical binding]; other site 941639006903 ligand binding site [chemical binding]; other site 941639006904 catalytic site [active] 941639006905 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 941639006906 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 941639006907 catalytic residue [active] 941639006908 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 941639006909 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 941639006910 ligand binding site [chemical binding]; other site 941639006911 NAD binding site [chemical binding]; other site 941639006912 dimerization interface [polypeptide binding]; other site 941639006913 catalytic site [active] 941639006914 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 941639006915 putative L-serine binding site [chemical binding]; other site 941639006916 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 941639006917 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 941639006918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639006919 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 941639006920 motif II; other site 941639006921 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 941639006922 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 941639006923 tetramer interface [polypeptide binding]; other site 941639006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639006925 catalytic residue [active] 941639006926 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 941639006927 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 941639006928 substrate binding site [chemical binding]; other site 941639006929 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 941639006930 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 941639006931 substrate binding site [chemical binding]; other site 941639006932 ligand binding site [chemical binding]; other site 941639006933 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 941639006934 tartrate dehydrogenase; Region: TTC; TIGR02089 941639006935 2-isopropylmalate synthase; Validated; Region: PRK00915 941639006936 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 941639006937 active site 941639006938 catalytic residues [active] 941639006939 metal binding site [ion binding]; metal-binding site 941639006940 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 941639006941 ketol-acid reductoisomerase; Provisional; Region: PRK05479 941639006942 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 941639006943 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 941639006944 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 941639006945 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 941639006946 putative valine binding site [chemical binding]; other site 941639006947 dimer interface [polypeptide binding]; other site 941639006948 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 941639006949 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 941639006950 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 941639006951 dimer interface [polypeptide binding]; other site 941639006952 PYR/PP interface [polypeptide binding]; other site 941639006953 TPP binding site [chemical binding]; other site 941639006954 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941639006955 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 941639006956 TPP-binding site [chemical binding]; other site 941639006957 dimer interface [polypeptide binding]; other site 941639006958 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 941639006959 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 941639006960 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 941639006961 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 941639006962 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 941639006963 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 941639006964 substrate binding site [chemical binding]; other site 941639006965 THF binding site; other site 941639006966 zinc-binding site [ion binding]; other site 941639006967 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639006968 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 941639006969 putative substrate translocation pore; other site 941639006970 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 941639006971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639006972 active site 941639006973 phosphorylation site [posttranslational modification] 941639006974 intermolecular recognition site; other site 941639006975 dimerization interface [polypeptide binding]; other site 941639006976 LytTr DNA-binding domain; Region: LytTR; pfam04397 941639006977 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 941639006978 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 941639006979 GAF domain; Region: GAF_3; pfam13492 941639006980 Histidine kinase; Region: His_kinase; pfam06580 941639006981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639006982 ATP binding site [chemical binding]; other site 941639006983 Mg2+ binding site [ion binding]; other site 941639006984 G-X-G motif; other site 941639006985 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 941639006986 active site 941639006987 homodimer interface [polypeptide binding]; other site 941639006988 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 941639006989 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 941639006990 Multicopper oxidase; Region: Cu-oxidase; pfam00394 941639006991 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 941639006992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941639006993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941639006994 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 941639006995 Predicted membrane protein [Function unknown]; Region: COG1511 941639006996 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 941639006997 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 941639006998 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 941639006999 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 941639007000 ATP11 protein; Region: ATP11; pfam06644 941639007001 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 941639007002 TIGR02680 family protein; Region: TIGR02680 941639007003 P-loop containing region of AAA domain; Region: AAA_29; cl17516 941639007004 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 941639007005 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 941639007006 TIGR02677 family protein; Region: TIGR02677 941639007007 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 941639007008 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 941639007009 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941639007010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 941639007011 Bacterial PH domain; Region: DUF304; pfam03703 941639007012 Bacterial PH domain; Region: DUF304; pfam03703 941639007013 Bacterial PH domain; Region: DUF304; pfam03703 941639007014 hypothetical protein; Provisional; Region: PRK06762 941639007015 proline/glycine betaine transporter; Provisional; Region: PRK10642 941639007016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007017 putative substrate translocation pore; other site 941639007018 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 941639007019 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 941639007020 FMN binding site [chemical binding]; other site 941639007021 active site 941639007022 catalytic residues [active] 941639007023 substrate binding site [chemical binding]; other site 941639007024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639007025 RNA binding surface [nucleotide binding]; other site 941639007026 HAMP domain; Region: HAMP; pfam00672 941639007027 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639007028 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639007029 dimer interface [polypeptide binding]; other site 941639007030 putative CheW interface [polypeptide binding]; other site 941639007031 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 941639007032 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 941639007033 active site 941639007034 recombination factor protein RarA; Reviewed; Region: PRK13342 941639007035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 941639007036 Walker A motif; other site 941639007037 ATP binding site [chemical binding]; other site 941639007038 Walker B motif; other site 941639007039 arginine finger; other site 941639007040 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 941639007041 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639007042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639007043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007044 Walker A/P-loop; other site 941639007045 ATP binding site [chemical binding]; other site 941639007046 Q-loop/lid; other site 941639007047 ABC transporter signature motif; other site 941639007048 Walker B; other site 941639007049 D-loop; other site 941639007050 H-loop/switch region; other site 941639007051 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941639007052 MarR family; Region: MarR_2; pfam12802 941639007053 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639007054 S-adenosylmethionine binding site [chemical binding]; other site 941639007055 TRAM domain; Region: TRAM; pfam01938 941639007056 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 941639007057 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 941639007058 endonuclease III; Region: ENDO3c; smart00478 941639007059 minor groove reading motif; other site 941639007060 helix-hairpin-helix signature motif; other site 941639007061 substrate binding pocket [chemical binding]; other site 941639007062 active site 941639007063 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 941639007064 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 941639007065 NodB motif; other site 941639007066 active site 941639007067 catalytic site [active] 941639007068 Cd binding site [ion binding]; other site 941639007069 YfkD-like protein; Region: YfkD; pfam14167 941639007070 calcium/proton exchanger (cax); Region: cax; TIGR00378 941639007071 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 941639007072 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 941639007073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639007075 putative substrate translocation pore; other site 941639007076 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 941639007077 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 941639007078 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 941639007079 active site 941639007080 intracellular protease, PfpI family; Region: PfpI; TIGR01382 941639007081 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 941639007082 proposed catalytic triad [active] 941639007083 conserved cys residue [active] 941639007084 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 941639007085 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 941639007086 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 941639007087 ligand binding site [chemical binding]; other site 941639007088 flagellar motor protein MotA; Validated; Region: PRK08124 941639007089 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 941639007090 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 941639007091 Protein of unknown function, DUF488; Region: DUF488; cl01246 941639007092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007093 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639007094 putative substrate translocation pore; other site 941639007095 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 941639007096 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 941639007097 rod-share determining protein MreBH; Provisional; Region: PRK13929 941639007098 MreB and similar proteins; Region: MreB_like; cd10225 941639007099 nucleotide binding site [chemical binding]; other site 941639007100 Mg binding site [ion binding]; other site 941639007101 putative protofilament interaction site [polypeptide binding]; other site 941639007102 RodZ interaction site [polypeptide binding]; other site 941639007103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 941639007104 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 941639007105 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 941639007106 cystathionine beta-lyase; Provisional; Region: PRK07671 941639007107 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 941639007108 homodimer interface [polypeptide binding]; other site 941639007109 substrate-cofactor binding pocket; other site 941639007110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639007111 catalytic residue [active] 941639007112 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 941639007113 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 941639007114 dimer interface [polypeptide binding]; other site 941639007115 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639007116 catalytic residue [active] 941639007117 S-ribosylhomocysteinase; Provisional; Region: PRK02260 941639007118 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639007119 S-adenosylmethionine binding site [chemical binding]; other site 941639007120 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 941639007121 active site clefts [active] 941639007122 zinc binding site [ion binding]; other site 941639007123 dimer interface [polypeptide binding]; other site 941639007124 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 941639007125 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 941639007126 active site 941639007127 metal binding site [ion binding]; metal-binding site 941639007128 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 941639007129 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639007130 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 941639007131 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 941639007132 DNA binding residues [nucleotide binding] 941639007133 dimerization interface [polypeptide binding]; other site 941639007134 Predicted secreted protein [Function unknown]; Region: COG4086 941639007135 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 941639007136 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941639007137 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941639007138 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941639007139 putative active site [active] 941639007140 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 941639007141 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 941639007142 active site 941639007143 metal binding site [ion binding]; metal-binding site 941639007144 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 941639007145 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941639007146 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 941639007147 catalytic core [active] 941639007148 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941639007149 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639007150 non-specific DNA binding site [nucleotide binding]; other site 941639007151 salt bridge; other site 941639007152 sequence-specific DNA binding site [nucleotide binding]; other site 941639007153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 941639007154 Transposase; Region: HTH_Tnp_1; pfam01527 941639007155 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639007156 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 941639007157 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 941639007158 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 941639007159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 941639007160 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 941639007161 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 941639007162 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 941639007163 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 941639007164 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 941639007165 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 941639007166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639007167 ATP binding site [chemical binding]; other site 941639007168 putative Mg++ binding site [ion binding]; other site 941639007169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639007170 nucleotide binding region [chemical binding]; other site 941639007171 ATP-binding site [chemical binding]; other site 941639007172 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 941639007173 putative FMN binding site [chemical binding]; other site 941639007174 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 941639007175 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 941639007176 homotetramer interface [polypeptide binding]; other site 941639007177 FMN binding site [chemical binding]; other site 941639007178 homodimer contacts [polypeptide binding]; other site 941639007179 putative active site [active] 941639007180 putative substrate binding site [chemical binding]; other site 941639007181 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 941639007182 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 941639007183 putative active site cavity [active] 941639007184 Helix-turn-helix domain; Region: HTH_17; cl17695 941639007185 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 941639007186 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 941639007187 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 941639007188 active site 941639007189 phosphorylation site [posttranslational modification] 941639007190 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 941639007191 active site 941639007192 P-loop; other site 941639007193 phosphorylation site [posttranslational modification] 941639007194 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 941639007195 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 941639007196 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 941639007197 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 941639007198 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 941639007199 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 941639007200 dimer interface [polypeptide binding]; other site 941639007201 active site 941639007202 metal binding site [ion binding]; metal-binding site 941639007203 Hemerythrin-like domain; Region: Hr-like; cd12108 941639007204 Fe binding site [ion binding]; other site 941639007205 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 941639007206 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 941639007207 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639007208 ATP binding site [chemical binding]; other site 941639007209 putative Mg++ binding site [ion binding]; other site 941639007210 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 941639007211 sugar phosphate phosphatase; Provisional; Region: PRK10513 941639007212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639007213 active site 941639007214 motif I; other site 941639007215 motif II; other site 941639007216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639007217 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 941639007218 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941639007219 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941639007220 HPr interaction site; other site 941639007221 active site 941639007222 phosphorylation site [posttranslational modification] 941639007223 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 941639007224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007226 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 941639007227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 941639007228 FeS/SAM binding site; other site 941639007229 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 941639007230 synthetase active site [active] 941639007231 NTP binding site [chemical binding]; other site 941639007232 metal binding site [ion binding]; metal-binding site 941639007233 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 941639007234 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941639007235 inhibitor-cofactor binding pocket; inhibition site 941639007236 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639007237 catalytic residue [active] 941639007238 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 941639007239 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 941639007240 active site 941639007241 catalytic tetrad [active] 941639007242 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 941639007243 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 941639007244 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 941639007245 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 941639007246 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 941639007247 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 941639007248 UreD urease accessory protein; Region: UreD; cl00530 941639007249 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941639007250 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 941639007251 UreF; Region: UreF; pfam01730 941639007252 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 941639007253 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 941639007254 dimer interface [polypeptide binding]; other site 941639007255 catalytic residues [active] 941639007256 urease subunit alpha; Reviewed; Region: ureC; PRK13207 941639007257 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 941639007258 subunit interactions [polypeptide binding]; other site 941639007259 active site 941639007260 flap region; other site 941639007261 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 941639007262 gamma-beta subunit interface [polypeptide binding]; other site 941639007263 alpha-beta subunit interface [polypeptide binding]; other site 941639007264 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 941639007265 alpha-gamma subunit interface [polypeptide binding]; other site 941639007266 beta-gamma subunit interface [polypeptide binding]; other site 941639007267 Transposase; Region: DEDD_Tnp_IS110; pfam01548 941639007268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 941639007269 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 941639007270 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 941639007271 dimer interface [polypeptide binding]; other site 941639007272 FMN binding site [chemical binding]; other site 941639007273 NADPH bind site [chemical binding]; other site 941639007274 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 941639007275 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 941639007276 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639007277 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 941639007278 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639007279 non-specific DNA binding site [nucleotide binding]; other site 941639007280 salt bridge; other site 941639007281 sequence-specific DNA binding site [nucleotide binding]; other site 941639007282 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 941639007283 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 941639007284 cofactor binding site; other site 941639007285 DNA binding site [nucleotide binding] 941639007286 substrate interaction site [chemical binding]; other site 941639007287 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 941639007288 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 941639007289 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 941639007290 active site 941639007291 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 941639007292 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 941639007293 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 941639007294 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941639007295 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639007296 potential frameshift: common BLAST hit: gi|239828605|ref|YP_002951229.1| transposase IS4 family protein 941639007297 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 941639007298 putative uracil/xanthine transporter; Provisional; Region: PRK11412 941639007299 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 941639007300 Part of AAA domain; Region: AAA_19; pfam13245 941639007301 Family description; Region: UvrD_C_2; pfam13538 941639007302 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 941639007303 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 941639007304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 941639007305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 941639007306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639007307 Coenzyme A binding pocket [chemical binding]; other site 941639007308 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 941639007309 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 941639007310 inhibitor-cofactor binding pocket; inhibition site 941639007311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 941639007312 catalytic residue [active] 941639007313 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 941639007314 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639007315 ATP binding site [chemical binding]; other site 941639007316 putative Mg++ binding site [ion binding]; other site 941639007317 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941639007318 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 941639007319 lysine transporter; Provisional; Region: PRK10836 941639007320 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 941639007321 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 941639007322 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 941639007323 ABC-2 type transporter; Region: ABC2_membrane; cl17235 941639007324 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 941639007325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941639007326 Walker A/P-loop; other site 941639007327 ATP binding site [chemical binding]; other site 941639007328 Q-loop/lid; other site 941639007329 ABC transporter signature motif; other site 941639007330 Walker B; other site 941639007331 D-loop; other site 941639007332 H-loop/switch region; other site 941639007333 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 941639007334 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 941639007335 [4Fe-4S] binding site [ion binding]; other site 941639007336 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941639007337 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 941639007338 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007339 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 941639007340 putative active site [active] 941639007341 catalytic residue [active] 941639007342 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 941639007343 catalytic residues [active] 941639007344 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 941639007345 active site 941639007346 catalytic residues [active] 941639007347 hydroperoxidase II; Provisional; Region: katE; PRK11249 941639007348 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 941639007349 tetramer interface [polypeptide binding]; other site 941639007350 heme binding pocket [chemical binding]; other site 941639007351 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 941639007352 domain interactions; other site 941639007353 LXG domain of WXG superfamily; Region: LXG; pfam04740 941639007354 LXG domain of WXG superfamily; Region: LXG; pfam04740 941639007355 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 941639007356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007357 Walker B; other site 941639007358 D-loop; other site 941639007359 H-loop/switch region; other site 941639007360 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 941639007361 PLD-like domain; Region: PLDc_2; pfam13091 941639007362 putative homodimer interface [polypeptide binding]; other site 941639007363 putative active site [active] 941639007364 catalytic site [active] 941639007365 DEAD-like helicases superfamily; Region: DEXDc; smart00487 941639007366 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639007367 ATP binding site [chemical binding]; other site 941639007368 putative Mg++ binding site [ion binding]; other site 941639007369 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639007370 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941639007371 nucleotide binding region [chemical binding]; other site 941639007372 ATP-binding site [chemical binding]; other site 941639007373 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 941639007374 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 941639007375 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 941639007376 Mrr N-terminal domain; Region: Mrr_N; pfam14338 941639007377 Restriction endonuclease; Region: Mrr_cat; pfam04471 941639007378 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 941639007379 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 941639007380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639007381 ATP binding site [chemical binding]; other site 941639007382 putative Mg++ binding site [ion binding]; other site 941639007383 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 941639007384 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 941639007385 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941639007386 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941639007387 HsdM N-terminal domain; Region: HsdM_N; pfam12161 941639007388 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 941639007389 Methyltransferase domain; Region: Methyltransf_26; pfam13659 941639007390 LysE type translocator; Region: LysE; pfam01810 941639007391 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 941639007392 catalytic residues [active] 941639007393 dimer interface [polypeptide binding]; other site 941639007394 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941639007395 HPr interaction site; other site 941639007396 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941639007397 active site 941639007398 phosphorylation site [posttranslational modification] 941639007399 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 941639007400 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 941639007401 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 941639007402 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 941639007403 Int/Topo IB signature motif; other site 941639007404 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 941639007405 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 941639007406 metal-binding site [ion binding] 941639007407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 941639007408 Soluble P-type ATPase [General function prediction only]; Region: COG4087 941639007409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 941639007410 dimerization interface [polypeptide binding]; other site 941639007411 putative DNA binding site [nucleotide binding]; other site 941639007412 putative Zn2+ binding site [ion binding]; other site 941639007413 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941639007414 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941639007415 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 941639007416 dimerization interface [polypeptide binding]; other site 941639007417 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 941639007418 Class III ribonucleotide reductase; Region: RNR_III; cd01675 941639007419 effector binding site; other site 941639007420 active site 941639007421 Zn binding site [ion binding]; other site 941639007422 hypothetical protein; Provisional; Region: PRK06851 941639007423 NTPase; Region: NTPase_1; cl17478 941639007424 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 941639007425 G1 box; other site 941639007426 GTP/Mg2+ binding site [chemical binding]; other site 941639007427 G2 box; other site 941639007428 Switch I region; other site 941639007429 G3 box; other site 941639007430 Switch II region; other site 941639007431 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 941639007432 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 941639007433 putative NAD(P) binding site [chemical binding]; other site 941639007434 catalytic Zn binding site [ion binding]; other site 941639007435 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 941639007436 Probable transposase; Region: OrfB_IS605; pfam01385 941639007437 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639007438 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 941639007439 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 941639007440 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 941639007441 ligand binding site [chemical binding]; other site 941639007442 dimerization interface [polypeptide binding]; other site 941639007443 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 941639007444 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 941639007445 TM-ABC transporter signature motif; other site 941639007446 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 941639007447 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 941639007448 Walker A/P-loop; other site 941639007449 ATP binding site [chemical binding]; other site 941639007450 Q-loop/lid; other site 941639007451 ABC transporter signature motif; other site 941639007452 Walker B; other site 941639007453 D-loop; other site 941639007454 H-loop/switch region; other site 941639007455 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 941639007456 D-ribose pyranase; Provisional; Region: PRK11797 941639007457 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 941639007458 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 941639007459 substrate binding site [chemical binding]; other site 941639007460 dimer interface [polypeptide binding]; other site 941639007461 ATP binding site [chemical binding]; other site 941639007462 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941639007463 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639007464 DNA binding site [nucleotide binding] 941639007465 domain linker motif; other site 941639007466 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 941639007467 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 941639007468 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 941639007469 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 941639007470 putative active site [active] 941639007471 putative NTP binding site [chemical binding]; other site 941639007472 putative nucleic acid binding site [nucleotide binding]; other site 941639007473 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 941639007474 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639007475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639007476 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 941639007477 Walker A/P-loop; other site 941639007478 ATP binding site [chemical binding]; other site 941639007479 Q-loop/lid; other site 941639007480 ABC transporter signature motif; other site 941639007481 Walker B; other site 941639007482 D-loop; other site 941639007483 H-loop/switch region; other site 941639007484 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639007485 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639007486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007487 Walker A/P-loop; other site 941639007488 ATP binding site [chemical binding]; other site 941639007489 Q-loop/lid; other site 941639007490 ABC transporter signature motif; other site 941639007491 Walker B; other site 941639007492 D-loop; other site 941639007493 H-loop/switch region; other site 941639007494 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 941639007495 MarR family; Region: MarR_2; pfam12802 941639007496 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639007497 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639007498 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 941639007499 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 941639007500 NlpC/P60 family; Region: NLPC_P60; pfam00877 941639007501 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 941639007502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639007503 Coenzyme A binding pocket [chemical binding]; other site 941639007504 Predicted amidohydrolase [General function prediction only]; Region: COG0388 941639007505 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 941639007506 putative active site [active] 941639007507 catalytic triad [active] 941639007508 putative dimer interface [polypeptide binding]; other site 941639007509 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 941639007510 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 941639007511 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 941639007512 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 941639007513 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 941639007514 Walker A/P-loop; other site 941639007515 ATP binding site [chemical binding]; other site 941639007516 Q-loop/lid; other site 941639007517 ABC transporter signature motif; other site 941639007518 Walker B; other site 941639007519 D-loop; other site 941639007520 H-loop/switch region; other site 941639007521 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 941639007522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639007523 dimer interface [polypeptide binding]; other site 941639007524 conserved gate region; other site 941639007525 putative PBP binding loops; other site 941639007526 ABC-ATPase subunit interface; other site 941639007527 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 941639007528 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 941639007529 active site 941639007530 dimer interface [polypeptide binding]; other site 941639007531 non-prolyl cis peptide bond; other site 941639007532 insertion regions; other site 941639007533 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 941639007534 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639007535 substrate binding pocket [chemical binding]; other site 941639007536 membrane-bound complex binding site; other site 941639007537 hinge residues; other site 941639007538 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 941639007539 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 941639007540 active site 941639007541 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 941639007542 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 941639007543 THF binding site; other site 941639007544 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 941639007545 substrate binding site [chemical binding]; other site 941639007546 THF binding site; other site 941639007547 zinc-binding site [ion binding]; other site 941639007548 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 941639007549 active site 941639007550 catalytic motif [active] 941639007551 Zn binding site [ion binding]; other site 941639007552 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 941639007553 intersubunit interface [polypeptide binding]; other site 941639007554 active site 941639007555 catalytic residue [active] 941639007556 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 941639007557 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 941639007558 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 941639007559 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 941639007560 phosphopentomutase; Provisional; Region: PRK05362 941639007561 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 941639007562 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 941639007563 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639007564 DNA binding residues [nucleotide binding] 941639007565 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 941639007566 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 941639007567 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 941639007568 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 941639007569 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 941639007570 Nucleoside recognition; Region: Gate; pfam07670 941639007571 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 941639007572 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941639007573 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 941639007574 putative substrate binding pocket [chemical binding]; other site 941639007575 AC domain interface; other site 941639007576 catalytic triad [active] 941639007577 AB domain interface; other site 941639007578 interchain disulfide; other site 941639007579 Predicted membrane protein [Function unknown]; Region: COG3817 941639007580 Protein of unknown function (DUF979); Region: DUF979; pfam06166 941639007581 Protein of unknown function (DUF969); Region: DUF969; pfam06149 941639007582 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 941639007583 putative active site [active] 941639007584 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 941639007585 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 941639007586 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 941639007587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639007589 putative substrate translocation pore; other site 941639007590 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 941639007591 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941639007592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007593 ABC transporter signature motif; other site 941639007594 Walker B; other site 941639007595 D-loop; other site 941639007596 H-loop/switch region; other site 941639007597 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941639007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639007599 dimer interface [polypeptide binding]; other site 941639007600 conserved gate region; other site 941639007601 putative PBP binding loops; other site 941639007602 ABC-ATPase subunit interface; other site 941639007603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639007604 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 941639007605 substrate binding pocket [chemical binding]; other site 941639007606 membrane-bound complex binding site; other site 941639007607 hinge residues; other site 941639007608 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 941639007609 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 941639007610 metal binding site [ion binding]; metal-binding site 941639007611 heat shock protein 90; Provisional; Region: PRK05218 941639007612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639007613 ATP binding site [chemical binding]; other site 941639007614 Mg2+ binding site [ion binding]; other site 941639007615 G-X-G motif; other site 941639007616 Eukaryotic cobalamin-binding protein; Region: Cobalamin_bind; pfam01122 941639007617 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 941639007618 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 941639007619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639007620 S-adenosylmethionine binding site [chemical binding]; other site 941639007621 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 941639007622 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 941639007623 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 941639007624 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 941639007625 NAD binding site [chemical binding]; other site 941639007626 substrate binding site [chemical binding]; other site 941639007627 catalytic Zn binding site [ion binding]; other site 941639007628 tetramer interface [polypeptide binding]; other site 941639007629 structural Zn binding site [ion binding]; other site 941639007630 potential frameshift: common BLAST hit: gi|219670864|ref|YP_002461299.1| transposase IS4 family protein 941639007631 DDE superfamily endonuclease; Region: DDE_5; cl17874 941639007632 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639007633 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 941639007634 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 941639007635 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 941639007636 RNA binding surface [nucleotide binding]; other site 941639007637 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 941639007638 Transposase [DNA replication, recombination, and repair]; Region: COG5421 941639007639 TRAM domain; Region: TRAM; pfam01938 941639007640 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 941639007641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639007642 S-adenosylmethionine binding site [chemical binding]; other site 941639007643 Transposase; Region: DEDD_Tnp_IS110; pfam01548 941639007644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 941639007645 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 941639007646 putative transporter; Provisional; Region: PRK10484 941639007647 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 941639007648 Na binding site [ion binding]; other site 941639007649 putative lipid kinase; Reviewed; Region: PRK13337 941639007650 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 941639007651 General stress protein [General function prediction only]; Region: GsiB; COG3729 941639007652 General stress protein [General function prediction only]; Region: GsiB; COG3729 941639007653 General stress protein [General function prediction only]; Region: GsiB; COG3729 941639007654 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 941639007655 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 941639007656 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 941639007657 GatB domain; Region: GatB_Yqey; smart00845 941639007658 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 941639007659 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 941639007660 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 941639007661 isocitrate lyase; Provisional; Region: PRK15063 941639007662 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 941639007663 tetramer interface [polypeptide binding]; other site 941639007664 active site 941639007665 Mg2+/Mn2+ binding site [ion binding]; other site 941639007666 malate synthase A; Region: malate_syn_A; TIGR01344 941639007667 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 941639007668 active site 941639007669 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 941639007670 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 941639007671 putative dimer interface [polypeptide binding]; other site 941639007672 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 941639007673 putative dimer interface [polypeptide binding]; other site 941639007674 Ligase N family; Region: LIGANc; smart00532 941639007675 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 941639007676 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 941639007677 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 941639007678 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 941639007679 Helix-hairpin-helix motif; Region: HHH; pfam00633 941639007680 helix-hairpin-helix signature motif; other site 941639007681 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 941639007682 Dimer interface [polypeptide binding]; other site 941639007683 AAA domain; Region: AAA_12; pfam13087 941639007684 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 941639007685 Family description; Region: UvrD_C_2; pfam13538 941639007686 Part of AAA domain; Region: AAA_19; pfam13245 941639007687 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 941639007688 substrate binding site [chemical binding]; other site 941639007689 putative active site [active] 941639007690 dimer interface [polypeptide binding]; other site 941639007691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 941639007692 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 941639007693 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 941639007694 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 941639007695 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 941639007696 active site 941639007697 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 941639007698 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 941639007699 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 941639007700 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 941639007701 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 941639007702 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 941639007703 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 941639007704 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 941639007705 purine monophosphate binding site [chemical binding]; other site 941639007706 dimer interface [polypeptide binding]; other site 941639007707 putative catalytic residues [active] 941639007708 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 941639007709 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 941639007710 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 941639007711 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 941639007712 active site 941639007713 substrate binding site [chemical binding]; other site 941639007714 cosubstrate binding site; other site 941639007715 catalytic site [active] 941639007716 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 941639007717 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 941639007718 dimerization interface [polypeptide binding]; other site 941639007719 putative ATP binding site [chemical binding]; other site 941639007720 amidophosphoribosyltransferase; Provisional; Region: PRK07631 941639007721 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 941639007722 active site 941639007723 tetramer interface [polypeptide binding]; other site 941639007724 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639007725 active site 941639007726 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 941639007727 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 941639007728 dimerization interface [polypeptide binding]; other site 941639007729 ATP binding site [chemical binding]; other site 941639007730 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 941639007731 dimerization interface [polypeptide binding]; other site 941639007732 ATP binding site [chemical binding]; other site 941639007733 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 941639007734 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 941639007735 putative active site [active] 941639007736 catalytic triad [active] 941639007737 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 941639007738 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 941639007739 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 941639007740 ATP binding site [chemical binding]; other site 941639007741 active site 941639007742 substrate binding site [chemical binding]; other site 941639007743 adenylosuccinate lyase; Provisional; Region: PRK07492 941639007744 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 941639007745 tetramer interface [polypeptide binding]; other site 941639007746 active site 941639007747 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 941639007748 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 941639007749 NAD binding site [chemical binding]; other site 941639007750 ATP-grasp domain; Region: ATP-grasp; pfam02222 941639007751 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 941639007752 NETI protein; Region: NETI; pfam14044 941639007753 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 941639007754 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 941639007755 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 941639007756 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 941639007757 catalytic residues [active] 941639007758 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 941639007759 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 941639007760 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 941639007761 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 941639007762 active site turn [active] 941639007763 phosphorylation site [posttranslational modification] 941639007764 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 941639007765 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 941639007766 HPr interaction site; other site 941639007767 glycerol kinase (GK) interaction site [polypeptide binding]; other site 941639007768 active site 941639007769 phosphorylation site [posttranslational modification] 941639007770 CAT RNA binding domain; Region: CAT_RBD; pfam03123 941639007771 transcriptional antiterminator BglG; Provisional; Region: PRK09772 941639007772 PRD domain; Region: PRD; pfam00874 941639007773 PRD domain; Region: PRD; pfam00874 941639007774 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 941639007775 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 941639007776 potential frameshift: common BLAST hit: gi|52082386|ref|YP_081177.1| glycoside hydrolase family protein 941639007777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007778 ABC transporter signature motif; other site 941639007779 Walker B; other site 941639007780 D-loop; other site 941639007781 H-loop/switch region; other site 941639007782 potential frameshift: common BLAST hit: gi|52082386|ref|YP_081177.1| glycoside hydrolase family protein 941639007783 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639007784 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639007785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007786 Walker A/P-loop; other site 941639007787 ATP binding site [chemical binding]; other site 941639007788 Q-loop/lid; other site 941639007789 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 941639007790 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007791 putative substrate translocation pore; other site 941639007792 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 941639007793 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 941639007794 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 941639007795 transmembrane helices; other site 941639007796 potential frameshift: common BLAST hit: gi|239826951|ref|YP_002949575.1| endonuclease I 941639007797 Endonuclease I; Region: Endonuclease_1; cl01003 941639007798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639007799 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639007800 Probable transposase; Region: OrfB_IS605; pfam01385 941639007801 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639007802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639007803 Walker A/P-loop; other site 941639007804 ATP binding site [chemical binding]; other site 941639007805 Q-loop/lid; other site 941639007806 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 941639007807 Predicted transcriptional regulators [Transcription]; Region: COG1725 941639007808 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639007809 DNA-binding site [nucleotide binding]; DNA binding site 941639007810 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 941639007811 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 941639007812 NADH(P)-binding; Region: NAD_binding_10; pfam13460 941639007813 NAD binding site [chemical binding]; other site 941639007814 substrate binding site [chemical binding]; other site 941639007815 putative active site [active] 941639007816 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 941639007817 hypothetical protein; Provisional; Region: PRK09609 941639007818 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 941639007819 CPxP motif; other site 941639007820 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 941639007821 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639007822 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639007823 Probable transposase; Region: OrfB_IS605; pfam01385 941639007824 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639007825 short chain dehydrogenase; Provisional; Region: PRK06701 941639007826 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 941639007827 NAD binding site [chemical binding]; other site 941639007828 metal binding site [ion binding]; metal-binding site 941639007829 active site 941639007830 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 941639007831 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941639007832 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941639007833 Transposase domain (DUF772); Region: DUF772; pfam05598 941639007834 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 941639007835 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639007836 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 941639007837 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 941639007838 intersubunit interface [polypeptide binding]; other site 941639007839 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 941639007840 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 941639007841 Walker A/P-loop; other site 941639007842 ATP binding site [chemical binding]; other site 941639007843 Q-loop/lid; other site 941639007844 ABC transporter signature motif; other site 941639007845 Walker B; other site 941639007846 D-loop; other site 941639007847 H-loop/switch region; other site 941639007848 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 941639007849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639007850 Transposase domain (DUF772); Region: DUF772; pfam05598 941639007851 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639007852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 941639007853 sequence-specific DNA binding site [nucleotide binding]; other site 941639007854 salt bridge; other site 941639007855 GMP synthase; Reviewed; Region: guaA; PRK00074 941639007856 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 941639007857 AMP/PPi binding site [chemical binding]; other site 941639007858 candidate oxyanion hole; other site 941639007859 catalytic triad [active] 941639007860 potential glutamine specificity residues [chemical binding]; other site 941639007861 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 941639007862 ATP Binding subdomain [chemical binding]; other site 941639007863 Ligand Binding sites [chemical binding]; other site 941639007864 Dimerization subdomain; other site 941639007865 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 941639007866 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 941639007867 homodimer interface [polypeptide binding]; other site 941639007868 NAD binding pocket [chemical binding]; other site 941639007869 ATP binding pocket [chemical binding]; other site 941639007870 Mg binding site [ion binding]; other site 941639007871 active-site loop [active] 941639007872 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 941639007873 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 941639007874 active site 941639007875 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 941639007876 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 941639007877 active site 941639007878 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 941639007879 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 941639007880 Ligand binding site; other site 941639007881 Putative Catalytic site; other site 941639007882 DXD motif; other site 941639007883 Predicted membrane protein [Function unknown]; Region: COG2246 941639007884 GtrA-like protein; Region: GtrA; pfam04138 941639007885 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 941639007886 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 941639007887 ring oligomerisation interface [polypeptide binding]; other site 941639007888 ATP/Mg binding site [chemical binding]; other site 941639007889 stacking interactions; other site 941639007890 hinge regions; other site 941639007891 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 941639007892 oligomerisation interface [polypeptide binding]; other site 941639007893 mobile loop; other site 941639007894 roof hairpin; other site 941639007895 CAAX protease self-immunity; Region: Abi; pfam02517 941639007896 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 941639007897 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 941639007898 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 941639007899 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 941639007900 CoA binding domain; Region: CoA_binding; pfam02629 941639007901 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 941639007902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639007903 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639007904 ABC transporter; Region: ABC_tran_2; pfam12848 941639007905 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 941639007906 ABC transporter; Region: ABC_tran_2; pfam12848 941639007907 UGMP family protein; Validated; Region: PRK09604 941639007908 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 941639007909 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 941639007910 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 941639007911 Coenzyme A binding pocket [chemical binding]; other site 941639007912 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 941639007913 Glycoprotease family; Region: Peptidase_M22; pfam00814 941639007914 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 941639007915 hypothetical protein; Provisional; Region: PRK04351 941639007916 SprT homologues; Region: SprT; cl01182 941639007917 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 941639007918 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 941639007919 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 941639007920 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 941639007921 RNA binding site [nucleotide binding]; other site 941639007922 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 941639007923 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 941639007924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 941639007925 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 941639007926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 941639007927 DNA binding residues [nucleotide binding] 941639007928 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 941639007929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639007930 ATP binding site [chemical binding]; other site 941639007931 Mg2+ binding site [ion binding]; other site 941639007932 G-X-G motif; other site 941639007933 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 941639007934 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 941639007935 anti sigma factor interaction site; other site 941639007936 regulatory phosphorylation site [posttranslational modification]; other site 941639007937 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 941639007938 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 941639007939 CoA binding domain; Region: CoA_binding; cl17356 941639007940 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 941639007941 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 941639007942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639007943 ATP binding site [chemical binding]; other site 941639007944 Mg2+ binding site [ion binding]; other site 941639007945 G-X-G motif; other site 941639007946 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 941639007947 Rsbr N terminal; Region: Rsbr_N; pfam08678 941639007948 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 941639007949 PemK-like protein; Region: PemK; pfam02452 941639007950 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 941639007951 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 941639007952 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 941639007953 active site 941639007954 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941639007955 dimer interface [polypeptide binding]; other site 941639007956 substrate binding site [chemical binding]; other site 941639007957 catalytic residues [active] 941639007958 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 941639007959 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 941639007960 Rhomboid family; Region: Rhomboid; pfam01694 941639007961 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 941639007962 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 941639007963 ATP binding site [chemical binding]; other site 941639007964 Mg++ binding site [ion binding]; other site 941639007965 motif III; other site 941639007966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639007967 nucleotide binding region [chemical binding]; other site 941639007968 ATP-binding site [chemical binding]; other site 941639007969 LysE type translocator; Region: LysE; pfam01810 941639007970 beta-phosphoglucomutase; Region: bPGM; TIGR01990 941639007971 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941639007972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639007973 motif II; other site 941639007974 Transcriptional regulators [Transcription]; Region: PurR; COG1609 941639007975 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 941639007976 DNA binding site [nucleotide binding] 941639007977 domain linker motif; other site 941639007978 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 941639007979 ligand binding site [chemical binding]; other site 941639007980 dimerization interface [polypeptide binding]; other site 941639007981 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 941639007982 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 941639007983 Ca binding site [ion binding]; other site 941639007984 active site 941639007985 catalytic site [active] 941639007986 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 941639007987 homodimer interface [polypeptide binding]; other site 941639007988 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 941639007989 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 941639007990 active site 941639007991 homodimer interface [polypeptide binding]; other site 941639007992 catalytic site [active] 941639007993 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 941639007994 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941639007995 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 941639007996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639007997 dimer interface [polypeptide binding]; other site 941639007998 conserved gate region; other site 941639007999 putative PBP binding loops; other site 941639008000 ABC-ATPase subunit interface; other site 941639008001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941639008002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639008003 dimer interface [polypeptide binding]; other site 941639008004 conserved gate region; other site 941639008005 putative PBP binding loops; other site 941639008006 ABC-ATPase subunit interface; other site 941639008007 Predicted integral membrane protein [Function unknown]; Region: COG5521 941639008008 maltose phosphorylase; Provisional; Region: PRK13807 941639008009 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 941639008010 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 941639008011 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 941639008012 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 941639008013 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 941639008014 Ca binding site [ion binding]; other site 941639008015 active site 941639008016 catalytic site [active] 941639008017 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 941639008018 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 941639008019 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 941639008020 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 941639008021 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 941639008022 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 941639008023 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 941639008024 Domain of unknown function DUF21; Region: DUF21; pfam01595 941639008025 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941639008026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941639008027 Transporter associated domain; Region: CorC_HlyC; smart01091 941639008028 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 941639008029 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 941639008030 DNA binding residues [nucleotide binding] 941639008031 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 941639008032 Domain of unknown function DUF21; Region: DUF21; pfam01595 941639008033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 941639008034 Transporter associated domain; Region: CorC_HlyC; smart01091 941639008035 Uncharacterized conserved protein [Function unknown]; Region: COG4715 941639008036 SNF2 Helicase protein; Region: DUF3670; pfam12419 941639008037 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 941639008038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639008039 ATP binding site [chemical binding]; other site 941639008040 putative Mg++ binding site [ion binding]; other site 941639008041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639008042 nucleotide binding region [chemical binding]; other site 941639008043 ATP-binding site [chemical binding]; other site 941639008044 YwpF-like protein; Region: YwpF; pfam14183 941639008045 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 941639008046 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941639008047 dimer interface [polypeptide binding]; other site 941639008048 ssDNA binding site [nucleotide binding]; other site 941639008049 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941639008050 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 941639008051 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 941639008052 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941639008053 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 941639008054 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 941639008055 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 941639008056 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 941639008057 rod shape-determining protein Mbl; Provisional; Region: PRK13928 941639008058 MreB and similar proteins; Region: MreB_like; cd10225 941639008059 nucleotide binding site [chemical binding]; other site 941639008060 Mg binding site [ion binding]; other site 941639008061 putative protofilament interaction site [polypeptide binding]; other site 941639008062 RodZ interaction site [polypeptide binding]; other site 941639008063 Stage III sporulation protein D; Region: SpoIIID; cl17560 941639008064 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 941639008065 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 941639008066 E3 interaction surface; other site 941639008067 lipoyl attachment site [posttranslational modification]; other site 941639008068 Stage II sporulation protein; Region: SpoIID; pfam08486 941639008069 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 941639008070 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 941639008071 hinge; other site 941639008072 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 941639008073 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 941639008074 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 941639008075 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 941639008076 gamma subunit interface [polypeptide binding]; other site 941639008077 epsilon subunit interface [polypeptide binding]; other site 941639008078 LBP interface [polypeptide binding]; other site 941639008079 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 941639008080 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941639008081 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 941639008082 alpha subunit interaction interface [polypeptide binding]; other site 941639008083 Walker A motif; other site 941639008084 ATP binding site [chemical binding]; other site 941639008085 Walker B motif; other site 941639008086 inhibitor binding site; inhibition site 941639008087 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941639008088 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 941639008089 delta subunit interface [polypeptide binding]; other site 941639008090 core domain interface [polypeptide binding]; other site 941639008091 epsilon subunit interface [polypeptide binding]; other site 941639008092 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 941639008093 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 941639008094 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 941639008095 beta subunit interaction interface [polypeptide binding]; other site 941639008096 Walker A motif; other site 941639008097 ATP binding site [chemical binding]; other site 941639008098 Walker B motif; other site 941639008099 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 941639008100 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 941639008101 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 941639008102 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 941639008103 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 941639008104 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 941639008105 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 941639008106 active site 941639008107 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 941639008108 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 941639008109 dimer interface [polypeptide binding]; other site 941639008110 active site 941639008111 glycine-pyridoxal phosphate binding site [chemical binding]; other site 941639008112 folate binding site [chemical binding]; other site 941639008113 hypothetical protein; Provisional; Region: PRK13690 941639008114 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 941639008115 HAMP domain; Region: HAMP; pfam00672 941639008116 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 941639008117 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 941639008118 dimer interface [polypeptide binding]; other site 941639008119 putative CheW interface [polypeptide binding]; other site 941639008120 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 941639008121 Low molecular weight phosphatase family; Region: LMWPc; cd00115 941639008122 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 941639008123 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 941639008124 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 941639008125 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 941639008126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639008127 peptide chain release factor 1; Validated; Region: prfA; PRK00591 941639008128 This domain is found in peptide chain release factors; Region: PCRF; smart00937 941639008129 RF-1 domain; Region: RF-1; pfam00472 941639008130 thymidine kinase; Provisional; Region: PRK04296 941639008131 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 941639008132 transcription termination factor Rho; Provisional; Region: rho; PRK09376 941639008133 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 941639008134 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 941639008135 RNA binding site [nucleotide binding]; other site 941639008136 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 941639008137 multimer interface [polypeptide binding]; other site 941639008138 Walker A motif; other site 941639008139 ATP binding site [chemical binding]; other site 941639008140 Walker B motif; other site 941639008141 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 941639008142 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 941639008143 putative active site [active] 941639008144 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 941639008145 active site 941639008146 hinge; other site 941639008147 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 941639008148 active site 941639008149 intersubunit interactions; other site 941639008150 catalytic residue [active] 941639008151 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 941639008152 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 941639008153 intersubunit interface [polypeptide binding]; other site 941639008154 active site 941639008155 zinc binding site [ion binding]; other site 941639008156 Na+ binding site [ion binding]; other site 941639008157 Response regulator receiver domain; Region: Response_reg; pfam00072 941639008158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639008159 active site 941639008160 phosphorylation site [posttranslational modification] 941639008161 intermolecular recognition site; other site 941639008162 dimerization interface [polypeptide binding]; other site 941639008163 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 941639008164 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 941639008165 Walker A/P-loop; other site 941639008166 ATP binding site [chemical binding]; other site 941639008167 Q-loop/lid; other site 941639008168 ABC transporter signature motif; other site 941639008169 Walker B; other site 941639008170 D-loop; other site 941639008171 H-loop/switch region; other site 941639008172 Predicted transcriptional regulators [Transcription]; Region: COG1725 941639008173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 941639008174 DNA-binding site [nucleotide binding]; DNA binding site 941639008175 CTP synthetase; Validated; Region: pyrG; PRK05380 941639008176 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 941639008177 UTP binding site [chemical binding]; other site 941639008178 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 941639008179 active site 941639008180 putative oxyanion hole; other site 941639008181 catalytic triad [active] 941639008182 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 941639008183 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 941639008184 B12 binding site [chemical binding]; other site 941639008185 cobalt ligand [ion binding]; other site 941639008186 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 941639008187 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941639008188 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 941639008189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941639008190 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 941639008191 FAD binding site [chemical binding]; other site 941639008192 homotetramer interface [polypeptide binding]; other site 941639008193 substrate binding pocket [chemical binding]; other site 941639008194 catalytic base [active] 941639008195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 941639008196 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 941639008197 FAD binding site [chemical binding]; other site 941639008198 homotetramer interface [polypeptide binding]; other site 941639008199 substrate binding pocket [chemical binding]; other site 941639008200 catalytic base [active] 941639008201 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 941639008202 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 941639008203 dimer interface [polypeptide binding]; other site 941639008204 active site 941639008205 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 941639008206 Cysteine-rich domain; Region: CCG; pfam02754 941639008207 Cysteine-rich domain; Region: CCG; pfam02754 941639008208 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 941639008209 putative active site [active] 941639008210 catalytic site [active] 941639008211 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 941639008212 PLD-like domain; Region: PLDc_2; pfam13091 941639008213 putative active site [active] 941639008214 catalytic site [active] 941639008215 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 941639008216 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 941639008217 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 941639008218 active site 941639008219 HIGH motif; other site 941639008220 KMSK motif region; other site 941639008221 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 941639008222 tRNA binding surface [nucleotide binding]; other site 941639008223 anticodon binding site; other site 941639008224 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 941639008225 agmatinase; Region: agmatinase; TIGR01230 941639008226 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 941639008227 putative active site [active] 941639008228 Mn binding site [ion binding]; other site 941639008229 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 941639008230 Transglycosylase; Region: Transgly; pfam00912 941639008231 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 941639008232 YwhD family; Region: YwhD; pfam08741 941639008233 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 941639008234 Peptidase family M50; Region: Peptidase_M50; pfam02163 941639008235 active site 941639008236 putative substrate binding region [chemical binding]; other site 941639008237 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 941639008238 active site 1 [active] 941639008239 dimer interface [polypeptide binding]; other site 941639008240 hexamer interface [polypeptide binding]; other site 941639008241 active site 2 [active] 941639008242 Uncharacterized conserved protein [Function unknown]; Region: COG3465 941639008243 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 941639008244 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 941639008245 Zn2+ binding site [ion binding]; other site 941639008246 Mg2+ binding site [ion binding]; other site 941639008247 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 941639008248 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 941639008249 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 941639008250 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 941639008251 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 941639008252 putative heme peroxidase; Provisional; Region: PRK12276 941639008253 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 941639008254 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 941639008255 Probable transposase; Region: OrfB_IS605; pfam01385 941639008256 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 941639008257 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 941639008258 ligand binding site [chemical binding]; other site 941639008259 active site 941639008260 UGI interface [polypeptide binding]; other site 941639008261 catalytic site [active] 941639008262 Heat induced stress protein YflT; Region: YflT; pfam11181 941639008263 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 941639008264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639008265 Walker A/P-loop; other site 941639008266 ATP binding site [chemical binding]; other site 941639008267 Q-loop/lid; other site 941639008268 ABC transporter signature motif; other site 941639008269 Walker B; other site 941639008270 D-loop; other site 941639008271 H-loop/switch region; other site 941639008272 Transposase domain (DUF772); Region: DUF772; pfam05598 941639008273 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639008274 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 941639008275 dimer interface [polypeptide binding]; other site 941639008276 substrate binding site [chemical binding]; other site 941639008277 ATP binding site [chemical binding]; other site 941639008278 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 941639008279 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 941639008280 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 941639008281 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 941639008282 active site 941639008283 motif I; other site 941639008284 motif II; other site 941639008285 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 941639008286 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 941639008287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639008288 ATP binding site [chemical binding]; other site 941639008289 putative Mg++ binding site [ion binding]; other site 941639008290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 941639008291 nucleotide binding region [chemical binding]; other site 941639008292 ATP-binding site [chemical binding]; other site 941639008293 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 941639008294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 941639008295 HRDC domain; Region: HRDC; pfam00570 941639008296 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 941639008297 DNA binding residues [nucleotide binding] 941639008298 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 941639008299 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 941639008300 dimer interface [polypeptide binding]; other site 941639008301 active site 941639008302 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 941639008303 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 941639008304 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 941639008305 putative active site [active] 941639008306 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 941639008307 PGAP1-like protein; Region: PGAP1; pfam07819 941639008308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 941639008309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639008310 dimer interface [polypeptide binding]; other site 941639008311 phosphorylation site [posttranslational modification] 941639008312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639008313 ATP binding site [chemical binding]; other site 941639008314 Mg2+ binding site [ion binding]; other site 941639008315 G-X-G motif; other site 941639008316 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639008317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639008318 active site 941639008319 phosphorylation site [posttranslational modification] 941639008320 intermolecular recognition site; other site 941639008321 dimerization interface [polypeptide binding]; other site 941639008322 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639008323 DNA binding site [nucleotide binding] 941639008324 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 941639008325 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 941639008326 putative deacylase active site [active] 941639008327 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 941639008328 holin-like protein; Validated; Region: PRK01658 941639008329 Transcriptional regulator [Transcription]; Region: LysR; COG0583 941639008330 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 941639008331 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 941639008332 putative dimerization interface [polypeptide binding]; other site 941639008333 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 941639008334 active site 941639008335 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 941639008336 dimer interface [polypeptide binding]; other site 941639008337 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 941639008338 Ligand Binding Site [chemical binding]; other site 941639008339 Molecular Tunnel; other site 941639008340 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 941639008341 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 941639008342 Uncharacterized conserved protein [Function unknown]; Region: COG2966 941639008343 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 941639008344 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 941639008345 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 941639008346 homodimer interface [polypeptide binding]; other site 941639008347 substrate-cofactor binding pocket; other site 941639008348 catalytic residue [active] 941639008349 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 941639008350 Carbon starvation protein CstA; Region: CstA; pfam02554 941639008351 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 941639008352 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 941639008353 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 941639008354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639008355 ABC-ATPase subunit interface; other site 941639008356 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 941639008357 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 941639008358 Walker A/P-loop; other site 941639008359 ATP binding site [chemical binding]; other site 941639008360 Q-loop/lid; other site 941639008361 ABC transporter signature motif; other site 941639008362 Walker B; other site 941639008363 D-loop; other site 941639008364 H-loop/switch region; other site 941639008365 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 941639008366 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 941639008367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639008368 Walker A/P-loop; other site 941639008369 ATP binding site [chemical binding]; other site 941639008370 Q-loop/lid; other site 941639008371 ABC transporter signature motif; other site 941639008372 Walker B; other site 941639008373 D-loop; other site 941639008374 H-loop/switch region; other site 941639008375 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 941639008376 Mg binding site [ion binding]; other site 941639008377 nucleotide binding site [chemical binding]; other site 941639008378 putative protofilament interface [polypeptide binding]; other site 941639008379 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 941639008380 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 941639008381 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 941639008382 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 941639008383 Ligand binding site; other site 941639008384 metal-binding site 941639008385 peptidase T; Region: peptidase-T; TIGR01882 941639008386 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 941639008387 metal binding site [ion binding]; metal-binding site 941639008388 dimer interface [polypeptide binding]; other site 941639008389 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 941639008390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639008391 putative substrate translocation pore; other site 941639008392 K+ potassium transporter; Region: K_trans; cl15781 941639008393 uracil transporter; Provisional; Region: PRK10720 941639008394 pyruvate dehydrogenase; Provisional; Region: PRK09124 941639008395 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 941639008396 PYR/PP interface [polypeptide binding]; other site 941639008397 tetramer interface [polypeptide binding]; other site 941639008398 dimer interface [polypeptide binding]; other site 941639008399 TPP binding site [chemical binding]; other site 941639008400 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 941639008401 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 941639008402 TPP-binding site [chemical binding]; other site 941639008403 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 941639008404 intersubunit interface [polypeptide binding]; other site 941639008405 active site 941639008406 catalytic residue [active] 941639008407 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941639008408 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639008409 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 941639008410 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 941639008411 Walker A/P-loop; other site 941639008412 ATP binding site [chemical binding]; other site 941639008413 Q-loop/lid; other site 941639008414 ABC transporter signature motif; other site 941639008415 Walker B; other site 941639008416 D-loop; other site 941639008417 H-loop/switch region; other site 941639008418 TOBE domain; Region: TOBE_2; pfam08402 941639008419 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 941639008420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639008421 dimer interface [polypeptide binding]; other site 941639008422 conserved gate region; other site 941639008423 putative PBP binding loops; other site 941639008424 ABC-ATPase subunit interface; other site 941639008425 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 941639008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639008427 dimer interface [polypeptide binding]; other site 941639008428 conserved gate region; other site 941639008429 putative PBP binding loops; other site 941639008430 ABC-ATPase subunit interface; other site 941639008431 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 941639008432 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 941639008433 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 941639008434 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 941639008435 active site 941639008436 catalytic site [active] 941639008437 metal binding site [ion binding]; metal-binding site 941639008438 dimer interface [polypeptide binding]; other site 941639008439 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 941639008440 Transposase domain (DUF772); Region: DUF772; pfam05598 941639008441 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 941639008442 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 941639008443 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639008444 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 941639008445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 941639008446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 941639008447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639008448 Walker A/P-loop; other site 941639008449 ATP binding site [chemical binding]; other site 941639008450 Q-loop/lid; other site 941639008451 ABC transporter signature motif; other site 941639008452 Walker B; other site 941639008453 D-loop; other site 941639008454 H-loop/switch region; other site 941639008455 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 941639008456 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 941639008457 MMPL family; Region: MMPL; pfam03176 941639008458 MMPL family; Region: MMPL; pfam03176 941639008459 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 941639008460 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 941639008461 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 941639008462 active site 941639008463 Na/Ca binding site [ion binding]; other site 941639008464 catalytic site [active] 941639008465 XFP C-terminal domain; Region: XFP_C; pfam09363 941639008466 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 941639008467 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 941639008468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 941639008469 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 941639008470 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 941639008471 dimer interface [polypeptide binding]; other site 941639008472 active site 941639008473 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941639008474 catalytic residues [active] 941639008475 substrate binding site [chemical binding]; other site 941639008476 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 941639008477 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 941639008478 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 941639008479 active site 941639008480 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 941639008481 dimer interface [polypeptide binding]; other site 941639008482 substrate binding site [chemical binding]; other site 941639008483 catalytic residue [active] 941639008484 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 941639008485 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 941639008486 substrate binding pocket [chemical binding]; other site 941639008487 membrane-bound complex binding site; other site 941639008488 hinge residues; other site 941639008489 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 941639008490 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 941639008491 ABC transporter signature motif; other site 941639008492 Walker B; other site 941639008493 D-loop; other site 941639008494 H-loop/switch region; other site 941639008495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639008496 dimer interface [polypeptide binding]; other site 941639008497 conserved gate region; other site 941639008498 ABC-ATPase subunit interface; other site 941639008499 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 941639008500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 941639008501 dimer interface [polypeptide binding]; other site 941639008502 conserved gate region; other site 941639008503 putative PBP binding loops; other site 941639008504 ABC-ATPase subunit interface; other site 941639008505 malate:quinone oxidoreductase; Validated; Region: PRK05257 941639008506 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 941639008507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 941639008508 Major Facilitator Superfamily; Region: MFS_1; pfam07690 941639008509 putative substrate translocation pore; other site 941639008510 Superfamily II helicase [General function prediction only]; Region: COG1204 941639008511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639008512 ATP binding site [chemical binding]; other site 941639008513 putative Mg++ binding site [ion binding]; other site 941639008514 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 941639008515 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 941639008516 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 941639008517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 941639008518 ATP binding site [chemical binding]; other site 941639008519 putative Mg++ binding site [ion binding]; other site 941639008520 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 941639008521 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941639008522 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 941639008523 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 941639008524 HsdM N-terminal domain; Region: HsdM_N; pfam12161 941639008525 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 941639008526 Methyltransferase domain; Region: Methyltransf_26; pfam13659 941639008527 Transposase, Mutator family; Region: Transposase_mut; pfam00872 941639008528 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 941639008529 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 941639008530 protein binding site [polypeptide binding]; other site 941639008531 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 941639008532 YycH protein; Region: YycI; pfam09648 941639008533 YycH protein; Region: YycH; pfam07435 941639008534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 941639008535 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 941639008536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 941639008537 dimerization interface [polypeptide binding]; other site 941639008538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 941639008539 putative active site [active] 941639008540 heme pocket [chemical binding]; other site 941639008541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 941639008542 dimer interface [polypeptide binding]; other site 941639008543 phosphorylation site [posttranslational modification] 941639008544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 941639008545 ATP binding site [chemical binding]; other site 941639008546 Mg2+ binding site [ion binding]; other site 941639008547 G-X-G motif; other site 941639008548 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 941639008549 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 941639008550 active site 941639008551 phosphorylation site [posttranslational modification] 941639008552 intermolecular recognition site; other site 941639008553 dimerization interface [polypeptide binding]; other site 941639008554 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 941639008555 DNA binding site [nucleotide binding] 941639008556 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 941639008557 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 941639008558 IMP binding site; other site 941639008559 replicative DNA helicase; Provisional; Region: PRK05748 941639008560 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 941639008561 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 941639008562 Walker A motif; other site 941639008563 ATP binding site [chemical binding]; other site 941639008564 Walker B motif; other site 941639008565 DNA binding loops [nucleotide binding] 941639008566 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 941639008567 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 941639008568 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 941639008569 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 941639008570 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 941639008571 DHH family; Region: DHH; pfam01368 941639008572 DHHA1 domain; Region: DHHA1; pfam02272 941639008573 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 941639008574 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 941639008575 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 941639008576 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 941639008577 dimer interface [polypeptide binding]; other site 941639008578 ssDNA binding site [nucleotide binding]; other site 941639008579 tetramer (dimer of dimers) interface [polypeptide binding]; other site 941639008580 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 941639008581 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 941639008582 homopentamer interface [polypeptide binding]; other site 941639008583 active site 941639008584 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 941639008585 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 941639008586 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 941639008587 dimerization interface [polypeptide binding]; other site 941639008588 active site 941639008589 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 941639008590 Lumazine binding domain; Region: Lum_binding; pfam00677 941639008591 Lumazine binding domain; Region: Lum_binding; pfam00677 941639008592 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 941639008593 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 941639008594 catalytic motif [active] 941639008595 Zn binding site [ion binding]; other site 941639008596 RibD C-terminal domain; Region: RibD_C; cl17279 941639008597 GTP-binding protein YchF; Reviewed; Region: PRK09601 941639008598 YchF GTPase; Region: YchF; cd01900 941639008599 G1 box; other site 941639008600 GTP/Mg2+ binding site [chemical binding]; other site 941639008601 Switch I region; other site 941639008602 G2 box; other site 941639008603 Switch II region; other site 941639008604 G3 box; other site 941639008605 G4 box; other site 941639008606 G5 box; other site 941639008607 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 941639008608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 941639008609 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 941639008610 Mechanosensitive ion channel; Region: MS_channel; pfam00924 941639008611 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 941639008612 Protein of unknown function (DUF554); Region: DUF554; pfam04474 941639008613 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 941639008614 ParB-like nuclease domain; Region: ParB; smart00470 941639008615 KorB domain; Region: KorB; pfam08535 941639008616 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 941639008617 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941639008618 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 941639008619 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 941639008620 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 941639008621 ParB-like nuclease domain; Region: ParBc; pfam02195 941639008622 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 941639008623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 941639008624 S-adenosylmethionine binding site [chemical binding]; other site 941639008625 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 941639008626 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 941639008627 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 941639008628 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 941639008629 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 941639008630 trmE is a tRNA modification GTPase; Region: trmE; cd04164 941639008631 G1 box; other site 941639008632 GTP/Mg2+ binding site [chemical binding]; other site 941639008633 Switch I region; other site 941639008634 G2 box; other site 941639008635 Switch II region; other site 941639008636 G3 box; other site 941639008637 G4 box; other site 941639008638 G5 box; other site 941639008639 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 941639008640 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 941639008641 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 941639008642 G-X-X-G motif; other site 941639008643 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 941639008644 RxxxH motif; other site 941639008645 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 941639008646 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 941639008647 ribonuclease P; Reviewed; Region: rnpA; PRK00499 941639008648 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399