-- dump date 20140618_221426 -- class Genbank::misc_feature -- table misc_feature_note -- id note 345219000001 aspartate kinase I; Reviewed; Region: PRK08210 345219000002 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 345219000003 nucleotide binding site [chemical binding]; other site 345219000004 substrate binding site [chemical binding]; other site 345219000005 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 345219000006 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 345219000007 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 345219000008 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 345219000009 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 345219000010 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 345219000011 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 345219000012 NAD binding site [chemical binding]; other site 345219000013 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 345219000014 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 345219000015 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 345219000016 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 345219000017 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 345219000018 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 345219000019 NodB motif; other site 345219000020 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 345219000021 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 345219000022 RNase E interface [polypeptide binding]; other site 345219000023 trimer interface [polypeptide binding]; other site 345219000024 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 345219000025 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 345219000026 RNase E interface [polypeptide binding]; other site 345219000027 trimer interface [polypeptide binding]; other site 345219000028 active site 345219000029 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 345219000030 putative nucleic acid binding region [nucleotide binding]; other site 345219000031 G-X-X-G motif; other site 345219000032 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 345219000033 RNA binding site [nucleotide binding]; other site 345219000034 domain interface; other site 345219000035 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 345219000036 16S/18S rRNA binding site [nucleotide binding]; other site 345219000037 S13e-L30e interaction site [polypeptide binding]; other site 345219000038 25S rRNA binding site [nucleotide binding]; other site 345219000039 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 345219000040 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 345219000041 active site 345219000042 Riboflavin kinase; Region: Flavokinase; pfam01687 345219000043 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 345219000044 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 345219000045 RNA binding site [nucleotide binding]; other site 345219000046 active site 345219000047 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 345219000048 Protein of unknown function (DUF503); Region: DUF503; cl00669 345219000049 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 345219000050 translation initiation factor IF-2; Region: IF-2; TIGR00487 345219000051 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 345219000052 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 345219000053 G1 box; other site 345219000054 putative GEF interaction site [polypeptide binding]; other site 345219000055 GTP/Mg2+ binding site [chemical binding]; other site 345219000056 Switch I region; other site 345219000057 G2 box; other site 345219000058 G3 box; other site 345219000059 Switch II region; other site 345219000060 G4 box; other site 345219000061 G5 box; other site 345219000062 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 345219000063 Translation-initiation factor 2; Region: IF-2; pfam11987 345219000064 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 345219000065 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 345219000066 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 345219000067 putative RNA binding cleft [nucleotide binding]; other site 345219000068 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 345219000069 NusA N-terminal domain; Region: NusA_N; pfam08529 345219000070 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 345219000071 RNA binding site [nucleotide binding]; other site 345219000072 homodimer interface [polypeptide binding]; other site 345219000073 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 345219000074 G-X-X-G motif; other site 345219000075 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 345219000076 G-X-X-G motif; other site 345219000077 ribosome maturation protein RimP; Reviewed; Region: PRK00092 345219000078 Sm and related proteins; Region: Sm_like; cl00259 345219000079 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 345219000080 putative oligomer interface [polypeptide binding]; other site 345219000081 putative RNA binding site [nucleotide binding]; other site 345219000082 DNA polymerase III PolC; Validated; Region: polC; PRK00448 345219000083 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 345219000084 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 345219000085 generic binding surface II; other site 345219000086 generic binding surface I; other site 345219000087 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 345219000088 active site 345219000089 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 345219000090 active site 345219000091 catalytic site [active] 345219000092 substrate binding site [chemical binding]; other site 345219000093 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 345219000094 prolyl-tRNA synthetase; Provisional; Region: PRK09194 345219000095 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 345219000096 dimer interface [polypeptide binding]; other site 345219000097 motif 1; other site 345219000098 active site 345219000099 motif 2; other site 345219000100 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 345219000101 putative deacylase active site [active] 345219000102 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 345219000103 active site 345219000104 motif 3; other site 345219000105 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 345219000106 anticodon binding site; other site 345219000107 RIP metalloprotease RseP; Region: TIGR00054 345219000108 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 345219000109 active site 345219000110 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 345219000111 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 345219000112 protein binding site [polypeptide binding]; other site 345219000113 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 345219000114 putative substrate binding region [chemical binding]; other site 345219000115 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 345219000116 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 345219000117 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 345219000118 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 345219000119 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 345219000120 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 345219000121 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 345219000122 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 345219000123 catalytic residue [active] 345219000124 putative FPP diphosphate binding site; other site 345219000125 putative FPP binding hydrophobic cleft; other site 345219000126 dimer interface [polypeptide binding]; other site 345219000127 putative IPP diphosphate binding site; other site 345219000128 ribosome recycling factor; Reviewed; Region: frr; PRK00083 345219000129 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 345219000130 hinge region; other site 345219000131 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 345219000132 putative nucleotide binding site [chemical binding]; other site 345219000133 uridine monophosphate binding site [chemical binding]; other site 345219000134 homohexameric interface [polypeptide binding]; other site 345219000135 elongation factor Ts; Provisional; Region: tsf; PRK09377 345219000136 UBA/TS-N domain; Region: UBA; pfam00627 345219000137 Elongation factor TS; Region: EF_TS; pfam00889 345219000138 Elongation factor TS; Region: EF_TS; pfam00889 345219000139 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 345219000140 rRNA interaction site [nucleotide binding]; other site 345219000141 S8 interaction site; other site 345219000142 putative laminin-1 binding site; other site 345219000143 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 345219000144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219000145 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 345219000146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219000147 DNA binding residues [nucleotide binding] 345219000148 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 345219000149 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 345219000150 CheC-like family; Region: CheC; pfam04509 345219000151 CheC-like family; Region: CheC; pfam04509 345219000152 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 345219000153 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 345219000154 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 345219000155 putative binding surface; other site 345219000156 active site 345219000157 P2 response regulator binding domain; Region: P2; pfam07194 345219000158 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 345219000159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219000160 ATP binding site [chemical binding]; other site 345219000161 Mg2+ binding site [ion binding]; other site 345219000162 G-X-G motif; other site 345219000163 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 345219000164 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 345219000165 CheB methylesterase; Region: CheB_methylest; pfam01339 345219000166 septum site-determining protein MinD; Region: minD_bact; TIGR01968 345219000167 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 345219000168 P-loop; other site 345219000169 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 345219000170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 345219000171 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 345219000172 FHIPEP family; Region: FHIPEP; pfam00771 345219000173 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 345219000174 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 345219000175 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 345219000176 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 345219000177 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 345219000178 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 345219000179 Response regulator receiver domain; Region: Response_reg; pfam00072 345219000180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219000181 active site 345219000182 phosphorylation site [posttranslational modification] 345219000183 intermolecular recognition site; other site 345219000184 dimerization interface [polypeptide binding]; other site 345219000185 flagellar motor switch protein; Validated; Region: PRK08119 345219000186 CheC-like family; Region: CheC; pfam04509 345219000187 CheC-like family; Region: CheC; pfam04509 345219000188 flagellar motor switch protein FliN; Region: fliN; TIGR02480 345219000189 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 345219000190 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 345219000191 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 345219000192 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 345219000193 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 345219000194 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 345219000195 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 345219000196 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 345219000197 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 345219000198 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 345219000199 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 345219000200 Uncharacterized conserved protein [Function unknown]; Region: COG3334 345219000201 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 345219000202 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 345219000203 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 345219000204 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 345219000205 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 345219000206 Walker A motif/ATP binding site; other site 345219000207 Walker B motif; other site 345219000208 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 345219000209 Flagellar assembly protein FliH; Region: FliH; pfam02108 345219000210 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 345219000211 MgtE intracellular N domain; Region: MgtE_N; smart00924 345219000212 FliG C-terminal domain; Region: FliG_C; pfam01706 345219000213 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 345219000214 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 345219000215 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 345219000216 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 345219000217 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 345219000218 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 345219000219 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 345219000220 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 345219000221 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 345219000222 transcriptional repressor CodY; Validated; Region: PRK04158 345219000223 CodY GAF-like domain; Region: CodY; pfam06018 345219000224 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 345219000225 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 345219000226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219000227 Walker A motif; other site 345219000228 ATP binding site [chemical binding]; other site 345219000229 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 345219000230 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 345219000231 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 345219000232 active site 345219000233 HslU subunit interaction site [polypeptide binding]; other site 345219000234 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 345219000235 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 345219000236 active site 345219000237 Int/Topo IB signature motif; other site 345219000238 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 345219000239 DNA topoisomerase; Region: Topoisom_bac; pfam01131 345219000240 domain I; other site 345219000241 DNA binding groove [nucleotide binding] 345219000242 phosphate binding site [ion binding]; other site 345219000243 domain II; other site 345219000244 domain III; other site 345219000245 nucleotide binding site [chemical binding]; other site 345219000246 catalytic site [active] 345219000247 domain IV; other site 345219000248 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 345219000249 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 345219000250 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 345219000251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 345219000252 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 345219000253 active site 345219000254 metal binding site [ion binding]; metal-binding site 345219000255 DNA protecting protein DprA; Region: dprA; TIGR00732 345219000256 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 345219000257 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 345219000258 CoA binding domain; Region: CoA_binding; pfam02629 345219000259 CoA-ligase; Region: Ligase_CoA; pfam00549 345219000260 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 345219000261 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 345219000262 CoA-ligase; Region: Ligase_CoA; pfam00549 345219000263 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 345219000264 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 345219000265 RNA/DNA hybrid binding site [nucleotide binding]; other site 345219000266 active site 345219000267 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 345219000268 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 345219000269 GTP/Mg2+ binding site [chemical binding]; other site 345219000270 G4 box; other site 345219000271 G5 box; other site 345219000272 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 345219000273 G1 box; other site 345219000274 G1 box; other site 345219000275 GTP/Mg2+ binding site [chemical binding]; other site 345219000276 Switch I region; other site 345219000277 G2 box; other site 345219000278 G2 box; other site 345219000279 G3 box; other site 345219000280 G3 box; other site 345219000281 Switch II region; other site 345219000282 Switch II region; other site 345219000283 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 345219000284 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 345219000285 Catalytic site [active] 345219000286 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 345219000287 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 345219000288 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 345219000289 RimM N-terminal domain; Region: RimM; pfam01782 345219000290 PRC-barrel domain; Region: PRC; pfam05239 345219000291 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 345219000292 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 345219000293 KH domain; Region: KH_4; pfam13083 345219000294 G-X-X-G motif; other site 345219000295 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 345219000296 signal recognition particle protein; Provisional; Region: PRK10867 345219000297 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 345219000298 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 345219000299 P loop; other site 345219000300 GTP binding site [chemical binding]; other site 345219000301 Signal peptide binding domain; Region: SRP_SPB; pfam02978 345219000302 putative DNA-binding protein; Validated; Region: PRK00118 345219000303 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 345219000304 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 345219000305 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 345219000306 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 345219000307 P loop; other site 345219000308 GTP binding site [chemical binding]; other site 345219000309 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 345219000310 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 345219000311 Walker A/P-loop; other site 345219000312 ATP binding site [chemical binding]; other site 345219000313 Q-loop/lid; other site 345219000314 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 345219000315 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 345219000316 ABC transporter signature motif; other site 345219000317 Walker B; other site 345219000318 D-loop; other site 345219000319 H-loop/switch region; other site 345219000320 ribonuclease III; Reviewed; Region: rnc; PRK00102 345219000321 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 345219000322 dimerization interface [polypeptide binding]; other site 345219000323 active site 345219000324 metal binding site [ion binding]; metal-binding site 345219000325 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 345219000326 dsRNA binding site [nucleotide binding]; other site 345219000327 acyl carrier protein; Provisional; Region: acpP; PRK00982 345219000328 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 345219000329 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 345219000330 NAD(P) binding site [chemical binding]; other site 345219000331 homotetramer interface [polypeptide binding]; other site 345219000332 homodimer interface [polypeptide binding]; other site 345219000333 active site 345219000334 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 345219000335 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 345219000336 putative phosphate acyltransferase; Provisional; Region: PRK05331 345219000337 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 345219000338 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 345219000339 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 345219000340 active site 2 [active] 345219000341 active site 1 [active] 345219000342 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 345219000343 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 345219000344 generic binding surface II; other site 345219000345 ssDNA binding site; other site 345219000346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219000347 ATP binding site [chemical binding]; other site 345219000348 putative Mg++ binding site [ion binding]; other site 345219000349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219000350 nucleotide binding region [chemical binding]; other site 345219000351 ATP-binding site [chemical binding]; other site 345219000352 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 345219000353 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 345219000354 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 345219000355 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 345219000356 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 345219000357 putative L-serine binding site [chemical binding]; other site 345219000358 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 345219000359 DAK2 domain; Region: Dak2; pfam02734 345219000360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 345219000361 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 345219000362 Thiamine pyrophosphokinase; Region: TPK; cd07995 345219000363 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 345219000364 active site 345219000365 dimerization interface [polypeptide binding]; other site 345219000366 thiamine binding site [chemical binding]; other site 345219000367 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 345219000368 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 345219000369 substrate binding site [chemical binding]; other site 345219000370 hexamer interface [polypeptide binding]; other site 345219000371 metal binding site [ion binding]; metal-binding site 345219000372 GTPase RsgA; Reviewed; Region: PRK00098 345219000373 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 345219000374 RNA binding site [nucleotide binding]; other site 345219000375 homodimer interface [polypeptide binding]; other site 345219000376 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 345219000377 GTPase/Zn-binding domain interface [polypeptide binding]; other site 345219000378 GTP/Mg2+ binding site [chemical binding]; other site 345219000379 G4 box; other site 345219000380 G5 box; other site 345219000381 G1 box; other site 345219000382 Switch I region; other site 345219000383 G2 box; other site 345219000384 G3 box; other site 345219000385 Switch II region; other site 345219000386 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 345219000387 Catalytic domain of Protein Kinases; Region: PKc; cd00180 345219000388 active site 345219000389 ATP binding site [chemical binding]; other site 345219000390 substrate binding site [chemical binding]; other site 345219000391 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 345219000392 substrate binding site [chemical binding]; other site 345219000393 activation loop (A-loop); other site 345219000394 activation loop (A-loop); other site 345219000395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 345219000396 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 345219000397 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 345219000398 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 345219000399 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 345219000400 Protein phosphatase 2C; Region: PP2C; pfam00481 345219000401 active site 345219000402 16S rRNA methyltransferase B; Provisional; Region: PRK14902 345219000403 NusB family; Region: NusB; pfam01029 345219000404 putative RNA binding site [nucleotide binding]; other site 345219000405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219000406 S-adenosylmethionine binding site [chemical binding]; other site 345219000407 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 345219000408 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 345219000409 putative active site [active] 345219000410 substrate binding site [chemical binding]; other site 345219000411 putative cosubstrate binding site; other site 345219000412 catalytic site [active] 345219000413 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 345219000414 substrate binding site [chemical binding]; other site 345219000415 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 345219000416 active site 345219000417 catalytic residues [active] 345219000418 metal binding site [ion binding]; metal-binding site 345219000419 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 345219000420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219000421 ATP binding site [chemical binding]; other site 345219000422 putative Mg++ binding site [ion binding]; other site 345219000423 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219000424 nucleotide binding region [chemical binding]; other site 345219000425 ATP-binding site [chemical binding]; other site 345219000426 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 345219000427 Flavoprotein; Region: Flavoprotein; pfam02441 345219000428 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 345219000429 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 345219000430 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 345219000431 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 345219000432 catalytic site [active] 345219000433 G-X2-G-X-G-K; other site 345219000434 hypothetical protein; Provisional; Region: PRK04323 345219000435 hypothetical protein; Provisional; Region: PRK11820 345219000436 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 345219000437 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 345219000438 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 345219000439 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 345219000440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 345219000441 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 345219000442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219000443 motif II; other site 345219000444 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 345219000445 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 345219000446 Domain of unknown function (DUF814); Region: DUF814; pfam05670 345219000447 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 345219000448 Sodium Bile acid symporter family; Region: SBF; pfam01758 345219000449 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 345219000450 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 345219000451 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 345219000452 active site 345219000453 Winged helix-turn helix; Region: HTH_29; pfam13551 345219000454 Homeodomain-like domain; Region: HTH_32; pfam13565 345219000455 Winged helix-turn helix; Region: HTH_33; pfam13592 345219000456 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 345219000457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219000458 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 345219000459 FAD binding domain; Region: FAD_binding_2; pfam00890 345219000460 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219000461 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 345219000462 active site 345219000463 motif I; other site 345219000464 motif II; other site 345219000465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219000466 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 345219000467 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 345219000468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219000469 Coenzyme A binding pocket [chemical binding]; other site 345219000470 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 345219000471 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219000472 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219000473 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 345219000474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219000475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219000476 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219000477 putative substrate translocation pore; other site 345219000478 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 345219000479 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 345219000480 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 345219000481 active site 345219000482 dimer interfaces [polypeptide binding]; other site 345219000483 catalytic residues [active] 345219000484 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 345219000485 rhamnulose-1-phosphate aldolase; Region: rhamnu_1P_ald; TIGR02624 345219000486 intersubunit interface [polypeptide binding]; other site 345219000487 active site 345219000488 Zn2+ binding site [ion binding]; other site 345219000489 L-rhamnose isomerase; Provisional; Region: PRK01076 345219000490 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 345219000491 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 345219000492 N- and C-terminal domain interface [polypeptide binding]; other site 345219000493 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 345219000494 active site 345219000495 putative catalytic site [active] 345219000496 metal binding site [ion binding]; metal-binding site 345219000497 ATP binding site [chemical binding]; other site 345219000498 carbohydrate binding site [chemical binding]; other site 345219000499 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 345219000500 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 345219000501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219000502 Nuclease-related domain; Region: NERD; pfam08378 345219000503 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219000504 active site 345219000505 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 345219000506 active site 345219000507 dimer interface [polypeptide binding]; other site 345219000508 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 345219000509 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 345219000510 heterodimer interface [polypeptide binding]; other site 345219000511 active site 345219000512 FMN binding site [chemical binding]; other site 345219000513 homodimer interface [polypeptide binding]; other site 345219000514 substrate binding site [chemical binding]; other site 345219000515 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 345219000516 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 345219000517 FAD binding pocket [chemical binding]; other site 345219000518 FAD binding motif [chemical binding]; other site 345219000519 phosphate binding motif [ion binding]; other site 345219000520 beta-alpha-beta structure motif; other site 345219000521 NAD binding pocket [chemical binding]; other site 345219000522 Iron coordination center [ion binding]; other site 345219000523 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 345219000524 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219000525 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 345219000526 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 345219000527 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219000528 ATP-grasp domain; Region: ATP-grasp_4; cl17255 345219000529 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 345219000530 IMP binding site; other site 345219000531 dimer interface [polypeptide binding]; other site 345219000532 interdomain contacts; other site 345219000533 partial ornithine binding site; other site 345219000534 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 345219000535 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 345219000536 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 345219000537 catalytic site [active] 345219000538 subunit interface [polypeptide binding]; other site 345219000539 dihydroorotase; Validated; Region: pyrC; PRK09357 345219000540 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 345219000541 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 345219000542 active site 345219000543 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 345219000544 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 345219000545 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 345219000546 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 345219000547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219000548 active site 345219000549 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 345219000550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219000551 RNA binding surface [nucleotide binding]; other site 345219000552 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 345219000553 active site 345219000554 lipoprotein signal peptidase; Provisional; Region: PRK14787 345219000555 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 345219000556 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 345219000557 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 345219000558 HIGH motif; other site 345219000559 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 345219000560 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 345219000561 active site 345219000562 KMSKS motif; other site 345219000563 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 345219000564 tRNA binding surface [nucleotide binding]; other site 345219000565 anticodon binding site; other site 345219000566 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 345219000567 DivIVA protein; Region: DivIVA; pfam05103 345219000568 DivIVA domain; Region: DivI1A_domain; TIGR03544 345219000569 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 345219000570 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 345219000571 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219000572 RNA binding surface [nucleotide binding]; other site 345219000573 YGGT family; Region: YGGT; pfam02325 345219000574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 345219000575 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 345219000576 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 345219000577 catalytic residue [active] 345219000578 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 345219000579 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 345219000580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219000581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 345219000582 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 345219000583 sporulation sigma factor SigG; Reviewed; Region: PRK08215 345219000584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219000585 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 345219000586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219000587 DNA binding residues [nucleotide binding] 345219000588 sporulation sigma factor SigE; Reviewed; Region: PRK08301 345219000589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219000590 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219000591 DNA binding residues [nucleotide binding] 345219000592 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219000593 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219000594 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219000595 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 345219000596 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 345219000597 cell division protein FtsZ; Validated; Region: PRK09330 345219000598 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 345219000599 nucleotide binding site [chemical binding]; other site 345219000600 SulA interaction site; other site 345219000601 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 345219000602 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 345219000603 nucleotide binding site [chemical binding]; other site 345219000604 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 345219000605 Cell division protein FtsA; Region: FtsA; pfam14450 345219000606 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 345219000607 Cell division protein FtsQ; Region: FtsQ; pfam03799 345219000608 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 345219000609 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 345219000610 active site 345219000611 homodimer interface [polypeptide binding]; other site 345219000612 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 345219000613 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 345219000614 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 345219000615 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 345219000616 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 345219000617 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 345219000618 Mg++ binding site [ion binding]; other site 345219000619 putative catalytic motif [active] 345219000620 putative substrate binding site [chemical binding]; other site 345219000621 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 345219000622 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 345219000623 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 345219000624 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 345219000625 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 345219000626 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 345219000627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 345219000628 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 345219000629 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 345219000630 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 345219000631 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 345219000632 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 345219000633 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 345219000634 Cell division protein FtsL; Region: FtsL; cl11433 345219000635 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 345219000636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219000637 S-adenosylmethionine binding site [chemical binding]; other site 345219000638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 345219000639 MraZ protein; Region: MraZ; pfam02381 345219000640 MraZ protein; Region: MraZ; pfam02381 345219000641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 345219000642 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 345219000643 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 345219000644 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 345219000645 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 345219000646 hypothetical protein; Provisional; Region: PRK13688 345219000647 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 345219000648 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 345219000649 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 345219000650 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 345219000651 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 345219000652 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 345219000653 hypothetical protein; Provisional; Region: PRK13670 345219000654 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 345219000655 PDZ domain of ATP-dependent LON serine proteases. Most PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. In this bacterial subfamily of protease-associated PDZ...; Region: PDZ_LON_protease; cd00986 345219000656 protein binding site [polypeptide binding]; other site 345219000657 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 345219000658 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 345219000659 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 345219000660 active site 345219000661 nucleophile elbow; other site 345219000662 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 345219000663 Nucleoside recognition; Region: Gate; pfam07670 345219000664 Nucleoside recognition; Region: Gate; pfam07670 345219000665 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 345219000666 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 345219000667 active site 345219000668 (T/H)XGH motif; other site 345219000669 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 345219000670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219000671 S-adenosylmethionine binding site [chemical binding]; other site 345219000672 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 345219000673 Protein of unknown function (DUF964); Region: DUF964; pfam06133 345219000674 YlbE-like protein; Region: YlbE; pfam14003 345219000675 Putative coat protein; Region: YlbD_coat; pfam14071 345219000676 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 345219000677 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 345219000678 CoenzymeA binding site [chemical binding]; other site 345219000679 subunit interaction site [polypeptide binding]; other site 345219000680 PHB binding site; other site 345219000681 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 345219000682 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 345219000683 YugN-like family; Region: YugN; pfam08868 345219000684 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 345219000685 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 345219000686 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 345219000687 Subunit I/III interface [polypeptide binding]; other site 345219000688 Subunit III/IV interface [polypeptide binding]; other site 345219000689 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 345219000690 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 345219000691 D-pathway; other site 345219000692 Putative ubiquinol binding site [chemical binding]; other site 345219000693 Low-spin heme (heme b) binding site [chemical binding]; other site 345219000694 Putative water exit pathway; other site 345219000695 Binuclear center (heme o3/CuB) [ion binding]; other site 345219000696 K-pathway; other site 345219000697 Putative proton exit pathway; other site 345219000698 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 345219000699 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 345219000700 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 345219000701 Cytochrome c; Region: Cytochrom_C; pfam00034 345219000702 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 345219000703 UbiA prenyltransferase family; Region: UbiA; pfam01040 345219000704 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 345219000705 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 345219000706 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 345219000707 hypothetical protein; Provisional; Region: PRK13666 345219000708 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 345219000709 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 345219000710 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 345219000711 putative active site [active] 345219000712 PhoH-like protein; Region: PhoH; pfam02562 345219000713 YlaH-like protein; Region: YlaH; pfam14036 345219000714 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 345219000715 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 345219000716 G1 box; other site 345219000717 putative GEF interaction site [polypeptide binding]; other site 345219000718 GTP/Mg2+ binding site [chemical binding]; other site 345219000719 Switch I region; other site 345219000720 G2 box; other site 345219000721 G3 box; other site 345219000722 Switch II region; other site 345219000723 G4 box; other site 345219000724 G5 box; other site 345219000725 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 345219000726 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 345219000727 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 345219000728 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 345219000729 active site 345219000730 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 345219000731 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 345219000732 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 345219000733 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 345219000734 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 345219000735 homodimer interface [polypeptide binding]; other site 345219000736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219000737 catalytic residue [active] 345219000738 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 345219000739 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 345219000740 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 345219000741 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 345219000742 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219000743 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 345219000744 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 345219000745 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 345219000746 E3 interaction surface; other site 345219000747 lipoyl attachment site [posttranslational modification]; other site 345219000748 e3 binding domain; Region: E3_binding; pfam02817 345219000749 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 345219000750 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 345219000751 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 345219000752 alpha subunit interface [polypeptide binding]; other site 345219000753 TPP binding site [chemical binding]; other site 345219000754 heterodimer interface [polypeptide binding]; other site 345219000755 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 345219000756 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 345219000757 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 345219000758 TPP-binding site [chemical binding]; other site 345219000759 tetramer interface [polypeptide binding]; other site 345219000760 heterodimer interface [polypeptide binding]; other site 345219000761 phosphorylation loop region [posttranslational modification] 345219000762 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 345219000763 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 345219000764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 345219000765 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 345219000766 YhfH-like protein; Region: YhfH; pfam14149 345219000767 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 345219000768 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 345219000769 metal binding site [ion binding]; metal-binding site 345219000770 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 345219000771 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 345219000772 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 345219000773 active site 345219000774 trimer interface [polypeptide binding]; other site 345219000775 substrate binding site [chemical binding]; other site 345219000776 CoA binding site [chemical binding]; other site 345219000777 Transcriptional regulator [Transcription]; Region: LysR; COG0583 345219000778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 345219000779 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 345219000780 dimerization interface [polypeptide binding]; other site 345219000781 FOG: CBS domain [General function prediction only]; Region: COG0517 345219000782 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 345219000783 Protein of unknown function (DUF1797); Region: DUF1797; pfam08796 345219000784 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 345219000785 short chain dehydrogenase; Provisional; Region: PRK07677 345219000786 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 345219000787 NAD(P) binding site [chemical binding]; other site 345219000788 substrate binding site [chemical binding]; other site 345219000789 homotetramer interface [polypeptide binding]; other site 345219000790 active site 345219000791 homodimer interface [polypeptide binding]; other site 345219000792 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 345219000793 metal binding site [ion binding]; metal-binding site 345219000794 active site 345219000795 I-site; other site 345219000796 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 345219000797 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 345219000798 YkyB-like protein; Region: YkyB; pfam14177 345219000799 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 345219000800 Response regulator receiver domain; Region: Response_reg; pfam00072 345219000801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219000802 active site 345219000803 phosphorylation site [posttranslational modification] 345219000804 intermolecular recognition site; other site 345219000805 dimerization interface [polypeptide binding]; other site 345219000806 aminotransferase A; Validated; Region: PRK07683 345219000807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219000808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219000809 homodimer interface [polypeptide binding]; other site 345219000810 catalytic residue [active] 345219000811 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 345219000812 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 345219000813 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 345219000814 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 345219000815 putative NAD(P) binding site [chemical binding]; other site 345219000816 putative active site [active] 345219000817 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 345219000818 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 345219000819 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 345219000820 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 345219000821 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 345219000822 dimerization domain swap beta strand [polypeptide binding]; other site 345219000823 regulatory protein interface [polypeptide binding]; other site 345219000824 active site 345219000825 regulatory phosphorylation site [posttranslational modification]; other site 345219000826 Uncharacterized protein conserved in bacteria (DUF2187); Region: DUF2187; pfam09953 345219000827 CAAX protease self-immunity; Region: Abi; pfam02517 345219000828 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 345219000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219000830 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 345219000831 Walker A motif; other site 345219000832 ATP binding site [chemical binding]; other site 345219000833 Walker B motif; other site 345219000834 arginine finger; other site 345219000835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219000836 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 345219000837 Walker A motif; other site 345219000838 ATP binding site [chemical binding]; other site 345219000839 Walker B motif; other site 345219000840 arginine finger; other site 345219000841 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 345219000842 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 345219000843 Uncharacterized conserved protein [Function unknown]; Region: COG3339 345219000844 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 345219000845 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 345219000846 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 345219000847 DNA binding site [nucleotide binding] 345219000848 active site 345219000849 PAS domain S-box; Region: sensory_box; TIGR00229 345219000850 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219000851 putative active site [active] 345219000852 heme pocket [chemical binding]; other site 345219000853 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 345219000854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219000855 putative active site [active] 345219000856 heme pocket [chemical binding]; other site 345219000857 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219000858 dimer interface [polypeptide binding]; other site 345219000859 phosphorylation site [posttranslational modification] 345219000860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219000861 ATP binding site [chemical binding]; other site 345219000862 Mg2+ binding site [ion binding]; other site 345219000863 G-X-G motif; other site 345219000864 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 345219000865 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 345219000866 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 345219000867 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 345219000868 G1 box; other site 345219000869 putative GEF interaction site [polypeptide binding]; other site 345219000870 GTP/Mg2+ binding site [chemical binding]; other site 345219000871 Switch I region; other site 345219000872 G2 box; other site 345219000873 G3 box; other site 345219000874 Switch II region; other site 345219000875 G4 box; other site 345219000876 G5 box; other site 345219000877 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 345219000878 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219000879 PAS domain; Region: PAS_9; pfam13426 345219000880 putative active site [active] 345219000881 heme pocket [chemical binding]; other site 345219000882 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219000883 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219000884 dimer interface [polypeptide binding]; other site 345219000885 phosphorylation site [posttranslational modification] 345219000886 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219000887 ATP binding site [chemical binding]; other site 345219000888 Mg2+ binding site [ion binding]; other site 345219000889 G-X-G motif; other site 345219000890 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 345219000891 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 345219000892 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 345219000893 Ferritin-like domain; Region: Ferritin; pfam00210 345219000894 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 345219000895 dimerization interface [polypeptide binding]; other site 345219000896 DPS ferroxidase diiron center [ion binding]; other site 345219000897 ion pore; other site 345219000898 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 345219000899 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 345219000900 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 345219000901 heme-binding site [chemical binding]; other site 345219000902 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 345219000903 FAD binding pocket [chemical binding]; other site 345219000904 FAD binding motif [chemical binding]; other site 345219000905 phosphate binding motif [ion binding]; other site 345219000906 beta-alpha-beta structure motif; other site 345219000907 NAD binding pocket [chemical binding]; other site 345219000908 Heme binding pocket [chemical binding]; other site 345219000909 Transcriptional regulator; Region: Rrf2; cl17282 345219000910 Rrf2 family protein; Region: rrf2_super; TIGR00738 345219000911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219000912 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219000913 putative substrate translocation pore; other site 345219000914 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 345219000915 short chain dehydrogenase; Provisional; Region: PRK06701 345219000916 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 345219000917 NAD binding site [chemical binding]; other site 345219000918 metal binding site [ion binding]; metal-binding site 345219000919 active site 345219000920 proline/glycine betaine transporter; Provisional; Region: PRK10642 345219000921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219000922 putative substrate translocation pore; other site 345219000923 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 345219000924 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 345219000925 putative ligand binding site [chemical binding]; other site 345219000926 putative NAD binding site [chemical binding]; other site 345219000927 catalytic site [active] 345219000928 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 345219000929 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 345219000930 HsdM N-terminal domain; Region: HsdM_N; pfam12161 345219000931 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 345219000932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 345219000933 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219000934 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 345219000935 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219000936 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 345219000937 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 345219000938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219000939 ATP binding site [chemical binding]; other site 345219000940 putative Mg++ binding site [ion binding]; other site 345219000941 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 345219000942 Protein of unknown function DUF45; Region: DUF45; pfam01863 345219000943 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 345219000944 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 345219000945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 345219000946 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 345219000947 substrate binding site [chemical binding]; other site 345219000948 THF binding site; other site 345219000949 zinc-binding site [ion binding]; other site 345219000950 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 345219000951 propionate/acetate kinase; Provisional; Region: PRK12379 345219000952 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 345219000953 Sensory domain found in PocR; Region: PocR; pfam10114 345219000954 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 345219000955 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219000956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219000957 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 345219000958 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219000959 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219000960 Probable transposase; Region: OrfB_IS605; pfam01385 345219000961 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 345219000962 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 345219000963 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 345219000964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219000965 putative DNA binding site [nucleotide binding]; other site 345219000966 putative Zn2+ binding site [ion binding]; other site 345219000967 AsnC family; Region: AsnC_trans_reg; pfam01037 345219000968 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 345219000969 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 345219000970 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 345219000971 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 345219000972 acyl-activating enzyme (AAE) consensus motif; other site 345219000973 putative AMP binding site [chemical binding]; other site 345219000974 putative active site [active] 345219000975 putative CoA binding site [chemical binding]; other site 345219000976 Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214 345219000977 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 345219000978 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 345219000979 active site 345219000980 Zn binding site [ion binding]; other site 345219000981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219000982 putative substrate translocation pore; other site 345219000983 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219000984 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 345219000985 trimer interface [polypeptide binding]; other site 345219000986 active site 345219000987 G bulge; other site 345219000988 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 345219000989 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 345219000990 ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269 345219000991 Walker A/P-loop; other site 345219000992 ATP binding site [chemical binding]; other site 345219000993 Q-loop/lid; other site 345219000994 ABC transporter signature motif; other site 345219000995 Walker B; other site 345219000996 D-loop; other site 345219000997 H-loop/switch region; other site 345219000998 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 345219000999 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 345219001000 classical (c) SDRs; Region: SDR_c; cd05233 345219001001 NAD(P) binding site [chemical binding]; other site 345219001002 active site 345219001003 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 345219001004 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 345219001005 nucleotide binding site [chemical binding]; other site 345219001006 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 345219001007 Putative esterase; Region: Esterase; pfam00756 345219001008 hypothetical protein; Provisional; Region: PRK13679 345219001009 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 345219001010 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219001011 Coenzyme A binding pocket [chemical binding]; other site 345219001012 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 345219001013 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 345219001014 stage V sporulation protein AD; Provisional; Region: PRK12404 345219001015 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 345219001016 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 345219001017 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 345219001018 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 345219001019 Spore coat protein Z; Region: Spore-coat_CotZ; pfam10612 345219001020 Spore coat protein CotO; Region: Spore_coat_CotO; pfam14153 345219001021 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 345219001022 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 345219001023 NAD binding site [chemical binding]; other site 345219001024 homotetramer interface [polypeptide binding]; other site 345219001025 homodimer interface [polypeptide binding]; other site 345219001026 substrate binding site [chemical binding]; other site 345219001027 active site 345219001028 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 345219001029 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 345219001030 active site 345219001031 metal binding site [ion binding]; metal-binding site 345219001032 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 345219001033 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 345219001034 active site 345219001035 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 345219001036 ATP-NAD kinase; Region: NAD_kinase; pfam01513 345219001037 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 345219001038 synthetase active site [active] 345219001039 NTP binding site [chemical binding]; other site 345219001040 metal binding site [ion binding]; metal-binding site 345219001041 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 345219001042 putative active site [active] 345219001043 putative metal binding residues [ion binding]; other site 345219001044 signature motif; other site 345219001045 putative triphosphate binding site [ion binding]; other site 345219001046 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 345219001047 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 345219001048 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 345219001049 N-acetyl-D-glucosamine binding site [chemical binding]; other site 345219001050 catalytic residue [active] 345219001051 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 345219001052 apolar tunnel; other site 345219001053 heme binding site [chemical binding]; other site 345219001054 dimerization interface [polypeptide binding]; other site 345219001055 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 345219001056 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 345219001057 catalytic residues [active] 345219001058 oligoendopeptidase F; Region: pepF; TIGR00181 345219001059 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 345219001060 active site 345219001061 Zn binding site [ion binding]; other site 345219001062 Competence protein CoiA-like family; Region: CoiA; cl11541 345219001063 adaptor protein; Provisional; Region: PRK02315 345219001064 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 345219001065 ArsC family; Region: ArsC; pfam03960 345219001066 putative catalytic residues [active] 345219001067 thiol/disulfide switch; other site 345219001068 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 345219001069 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219001070 Walker A/P-loop; other site 345219001071 ATP binding site [chemical binding]; other site 345219001072 Q-loop/lid; other site 345219001073 ABC transporter signature motif; other site 345219001074 Walker B; other site 345219001075 D-loop; other site 345219001076 H-loop/switch region; other site 345219001077 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 345219001078 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 345219001079 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219001080 Walker A/P-loop; other site 345219001081 ATP binding site [chemical binding]; other site 345219001082 Q-loop/lid; other site 345219001083 ABC transporter signature motif; other site 345219001084 Walker B; other site 345219001085 D-loop; other site 345219001086 H-loop/switch region; other site 345219001087 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 345219001088 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 345219001089 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 345219001090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001091 dimer interface [polypeptide binding]; other site 345219001092 conserved gate region; other site 345219001093 putative PBP binding loops; other site 345219001094 ABC-ATPase subunit interface; other site 345219001095 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 345219001096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001097 dimer interface [polypeptide binding]; other site 345219001098 conserved gate region; other site 345219001099 putative PBP binding loops; other site 345219001100 ABC-ATPase subunit interface; other site 345219001101 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 345219001102 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 345219001103 peptide binding site [polypeptide binding]; other site 345219001104 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 345219001105 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 345219001106 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 345219001107 active site 345219001108 HIGH motif; other site 345219001109 dimer interface [polypeptide binding]; other site 345219001110 KMSKS motif; other site 345219001111 Protein of unknown function (DUF3603); Region: DUF3603; pfam12227 345219001112 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 345219001113 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 345219001114 peptide binding site [polypeptide binding]; other site 345219001115 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 345219001116 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 345219001117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001118 dimer interface [polypeptide binding]; other site 345219001119 conserved gate region; other site 345219001120 putative PBP binding loops; other site 345219001121 ABC-ATPase subunit interface; other site 345219001122 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 345219001123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001124 dimer interface [polypeptide binding]; other site 345219001125 conserved gate region; other site 345219001126 putative PBP binding loops; other site 345219001127 ABC-ATPase subunit interface; other site 345219001128 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 345219001129 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219001130 Walker A/P-loop; other site 345219001131 ATP binding site [chemical binding]; other site 345219001132 Q-loop/lid; other site 345219001133 ABC transporter signature motif; other site 345219001134 Walker B; other site 345219001135 D-loop; other site 345219001136 H-loop/switch region; other site 345219001137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 345219001138 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 345219001139 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219001140 Walker A/P-loop; other site 345219001141 ATP binding site [chemical binding]; other site 345219001142 Q-loop/lid; other site 345219001143 ABC transporter signature motif; other site 345219001144 Walker B; other site 345219001145 D-loop; other site 345219001146 H-loop/switch region; other site 345219001147 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 345219001148 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 345219001149 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 345219001150 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 345219001151 dimer interface [polypeptide binding]; other site 345219001152 active site 345219001153 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 345219001154 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 345219001155 dimer interface [polypeptide binding]; other site 345219001156 active site 345219001157 CoA binding pocket [chemical binding]; other site 345219001158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219001159 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219001160 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 345219001161 Clp amino terminal domain; Region: Clp_N; pfam02861 345219001162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219001163 Walker A motif; other site 345219001164 ATP binding site [chemical binding]; other site 345219001165 Walker B motif; other site 345219001166 arginine finger; other site 345219001167 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 345219001168 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219001169 Walker A motif; other site 345219001170 ATP binding site [chemical binding]; other site 345219001171 Walker B motif; other site 345219001172 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 345219001173 YjzC-like protein; Region: YjzC; pfam14168 345219001174 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 345219001175 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 345219001176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219001177 active site 345219001178 motif I; other site 345219001179 motif II; other site 345219001180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219001181 Protein of unknown function (DUF3813); Region: DUF3813; pfam12758 345219001182 EDD domain protein, DegV family; Region: DegV; TIGR00762 345219001183 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 345219001184 short chain dehydrogenase; Provisional; Region: PRK06701 345219001185 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 345219001186 NAD binding site [chemical binding]; other site 345219001187 metal binding site [ion binding]; metal-binding site 345219001188 active site 345219001189 Protein of unknown function (DUF2777); Region: DUF2777; pfam10949 345219001190 hypothetical protein; Provisional; Region: PRK13673 345219001191 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 345219001192 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 345219001193 Predicted membrane protein [Function unknown]; Region: COG2311 345219001194 Protein of unknown function (DUF418); Region: DUF418; pfam04235 345219001195 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 345219001196 Spore germination protein GerPC; Region: GerPC; pfam10737 345219001197 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 345219001198 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 345219001199 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 345219001200 Part of AAA domain; Region: AAA_19; pfam13245 345219001201 Protein-interacting Bro1-like domain of mammalian Alix and related domains; Region: BRO1_Alix_like; cl14649 345219001202 Family description; Region: UvrD_C_2; pfam13538 345219001203 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 345219001204 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 345219001205 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 345219001206 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 345219001207 ComK protein; Region: ComK; pfam06338 345219001208 IDEAL domain; Region: IDEAL; pfam08858 345219001209 Peptidase family M48; Region: Peptidase_M48; pfam01435 345219001210 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 345219001211 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 345219001212 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 345219001213 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 345219001214 acyl-activating enzyme (AAE) consensus motif; other site 345219001215 putative AMP binding site [chemical binding]; other site 345219001216 putative active site [active] 345219001217 putative CoA binding site [chemical binding]; other site 345219001218 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 345219001219 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 345219001220 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 345219001221 YhfH-like protein; Region: YhfH; pfam14149 345219001222 YtkA-like; Region: YtkA; pfam13115 345219001223 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 345219001224 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 345219001225 Cu(I) binding site [ion binding]; other site 345219001226 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 345219001227 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 345219001228 NAD binding site [chemical binding]; other site 345219001229 catalytic residues [active] 345219001230 substrate binding site [chemical binding]; other site 345219001231 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 345219001232 EamA-like transporter family; Region: EamA; pfam00892 345219001233 EamA-like transporter family; Region: EamA; pfam00892 345219001234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219001235 putative substrate translocation pore; other site 345219001236 Domain of unknown function (DUF718); Region: DUF718; cl01281 345219001237 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 345219001238 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 345219001239 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 345219001240 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 345219001241 active site turn [active] 345219001242 phosphorylation site [posttranslational modification] 345219001243 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 345219001244 HPr interaction site; other site 345219001245 glycerol kinase (GK) interaction site [polypeptide binding]; other site 345219001246 active site 345219001247 phosphorylation site [posttranslational modification] 345219001248 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 345219001249 Predicted membrane protein [Function unknown]; Region: COG1511 345219001250 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 345219001251 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 345219001252 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 345219001253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219001254 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219001255 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 345219001256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 345219001257 ferrochelatase; Provisional; Region: PRK12435 345219001258 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 345219001259 C-terminal domain interface [polypeptide binding]; other site 345219001260 active site 345219001261 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 345219001262 active site 345219001263 N-terminal domain interface [polypeptide binding]; other site 345219001264 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 345219001265 substrate binding site [chemical binding]; other site 345219001266 active site 345219001267 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 345219001268 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 345219001269 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 345219001270 metal binding site [ion binding]; metal-binding site 345219001271 dimer interface [polypeptide binding]; other site 345219001272 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 345219001273 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 345219001274 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219001275 Walker A/P-loop; other site 345219001276 ATP binding site [chemical binding]; other site 345219001277 Q-loop/lid; other site 345219001278 ABC transporter signature motif; other site 345219001279 Walker B; other site 345219001280 D-loop; other site 345219001281 H-loop/switch region; other site 345219001282 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 345219001283 HIT family signature motif; other site 345219001284 catalytic residue [active] 345219001285 Gas vesicle protein [General function prediction only]; Region: GvpP; COG4980 345219001286 transcriptional regulator Hpr; Provisional; Region: PRK13777 345219001287 MarR family; Region: MarR; pfam01047 345219001288 Protein of unknown function (DUF1878); Region: DUF1878; pfam08963 345219001289 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 345219001290 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 345219001291 Sporulation protein YhaL; Region: Spore_YhaL; pfam14147 345219001292 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 345219001293 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 345219001294 generic binding surface II; other site 345219001295 generic binding surface I; other site 345219001296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219001297 Zn2+ binding site [ion binding]; other site 345219001298 Mg2+ binding site [ion binding]; other site 345219001299 Uncharacterized conserved protein [Function unknown]; Region: COG4717 345219001300 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 345219001301 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 345219001302 active site 345219001303 metal binding site [ion binding]; metal-binding site 345219001304 DNA binding site [nucleotide binding] 345219001305 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 345219001306 Predicted permeases [General function prediction only]; Region: COG0701 345219001307 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 345219001308 YhzD-like protein; Region: YhzD; pfam14120 345219001309 enoyl-CoA hydratase; Provisional; Region: PRK07659 345219001310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 345219001311 substrate binding site [chemical binding]; other site 345219001312 oxyanion hole (OAH) forming residues; other site 345219001313 trimer interface [polypeptide binding]; other site 345219001314 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 345219001315 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 345219001316 motif I; other site 345219001317 motif II; other site 345219001318 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 345219001319 hypothetical protein; Provisional; Region: PRK13676 345219001320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 345219001321 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 345219001322 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 345219001323 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 345219001324 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 345219001325 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 345219001326 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 345219001327 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 345219001328 Walker A/P-loop; other site 345219001329 ATP binding site [chemical binding]; other site 345219001330 Q-loop/lid; other site 345219001331 ABC transporter signature motif; other site 345219001332 Walker B; other site 345219001333 D-loop; other site 345219001334 H-loop/switch region; other site 345219001335 TOBE domain; Region: TOBE; pfam03459 345219001336 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 345219001337 fumarate hydratase; Reviewed; Region: fumC; PRK00485 345219001338 Class II fumarases; Region: Fumarase_classII; cd01362 345219001339 active site 345219001340 tetramer interface [polypeptide binding]; other site 345219001341 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219001342 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219001343 Clp protease; Region: CLP_protease; pfam00574 345219001344 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 345219001345 oligomer interface [polypeptide binding]; other site 345219001346 active site residues [active] 345219001347 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 345219001348 dimerization domain swap beta strand [polypeptide binding]; other site 345219001349 regulatory protein interface [polypeptide binding]; other site 345219001350 active site 345219001351 regulatory phosphorylation site [posttranslational modification]; other site 345219001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 345219001353 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 345219001354 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 345219001355 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 345219001356 phosphate binding site [ion binding]; other site 345219001357 putative substrate binding pocket [chemical binding]; other site 345219001358 dimer interface [polypeptide binding]; other site 345219001359 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 345219001360 AAA domain; Region: AAA_18; pfam13238 345219001361 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 345219001362 putative active site [active] 345219001363 nucleotide binding site [chemical binding]; other site 345219001364 nudix motif; other site 345219001365 putative metal binding site [ion binding]; other site 345219001366 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 345219001367 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 345219001368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 345219001369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219001370 TPR repeat; Region: TPR_11; pfam13414 345219001371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219001372 binding surface 345219001373 TPR motif; other site 345219001374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219001375 binding surface 345219001376 Tetratricopeptide repeat; Region: TPR_16; pfam13432 345219001377 TPR motif; other site 345219001378 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 345219001379 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 345219001380 trimer interface [polypeptide binding]; other site 345219001381 active site 345219001382 substrate binding site [chemical binding]; other site 345219001383 CoA binding site [chemical binding]; other site 345219001384 pyrophosphatase PpaX; Provisional; Region: PRK13288 345219001385 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 345219001386 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219001387 motif II; other site 345219001388 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 345219001389 HPr kinase/phosphorylase; Provisional; Region: PRK05428 345219001390 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 345219001391 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 345219001392 Hpr binding site; other site 345219001393 active site 345219001394 homohexamer subunit interaction site [polypeptide binding]; other site 345219001395 Membrane protein of unknown function; Region: DUF360; cl00850 345219001396 Uncharacterized conserved protein [Function unknown]; Region: COG3595 345219001397 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 345219001398 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 345219001399 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 345219001400 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 345219001401 SH3-like domain; Region: SH3_8; pfam13457 345219001402 SH3-like domain; Region: SH3_8; pfam13457 345219001403 SH3-like domain; Region: SH3_8; pfam13457 345219001404 SH3-like domain; Region: SH3_8; pfam13457 345219001405 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 345219001406 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 345219001407 putative ADP-binding pocket [chemical binding]; other site 345219001408 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 345219001409 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 345219001410 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 345219001411 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 345219001412 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 345219001413 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 345219001414 glycerol-3-phosphate cytidylyltransferase; Region: G3P_Cytidylyltransferase; cd02171 345219001415 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 345219001416 active site 345219001417 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 345219001418 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 345219001419 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 345219001420 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 345219001421 excinuclease ABC subunit B; Provisional; Region: PRK05298 345219001422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219001423 ATP binding site [chemical binding]; other site 345219001424 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219001425 nucleotide binding region [chemical binding]; other site 345219001426 ATP-binding site [chemical binding]; other site 345219001427 Ultra-violet resistance protein B; Region: UvrB; pfam12344 345219001428 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 345219001429 Uncharacterized protein conserved in bacteria (DUF2198); Region: DUF2198; cl11559 345219001430 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219001431 Zn2+ binding site [ion binding]; other site 345219001432 Mg2+ binding site [ion binding]; other site 345219001433 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 345219001434 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 345219001435 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 345219001436 Ligand binding site; other site 345219001437 Putative Catalytic site; other site 345219001438 DXD motif; other site 345219001439 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 345219001440 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 345219001441 Walker A/P-loop; other site 345219001442 ATP binding site [chemical binding]; other site 345219001443 Q-loop/lid; other site 345219001444 ABC transporter signature motif; other site 345219001445 Walker B; other site 345219001446 D-loop; other site 345219001447 H-loop/switch region; other site 345219001448 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 345219001449 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 345219001450 Walker A/P-loop; other site 345219001451 ATP binding site [chemical binding]; other site 345219001452 Q-loop/lid; other site 345219001453 ABC transporter signature motif; other site 345219001454 Walker B; other site 345219001455 D-loop; other site 345219001456 H-loop/switch region; other site 345219001457 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 345219001458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001459 dimer interface [polypeptide binding]; other site 345219001460 conserved gate region; other site 345219001461 putative PBP binding loops; other site 345219001462 ABC-ATPase subunit interface; other site 345219001463 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 345219001464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001465 dimer interface [polypeptide binding]; other site 345219001466 conserved gate region; other site 345219001467 putative PBP binding loops; other site 345219001468 ABC-ATPase subunit interface; other site 345219001469 PBP superfamily domain; Region: PBP_like_2; cl17296 345219001470 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 345219001471 protoporphyrinogen oxidase; Provisional; Region: PRK12416 345219001472 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219001473 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219001474 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 345219001475 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219001476 dimerization interface [polypeptide binding]; other site 345219001477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219001478 putative active site [active] 345219001479 heme pocket [chemical binding]; other site 345219001480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219001481 dimer interface [polypeptide binding]; other site 345219001482 phosphorylation site [posttranslational modification] 345219001483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219001484 ATP binding site [chemical binding]; other site 345219001485 Mg2+ binding site [ion binding]; other site 345219001486 G-X-G motif; other site 345219001487 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219001488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219001489 active site 345219001490 phosphorylation site [posttranslational modification] 345219001491 intermolecular recognition site; other site 345219001492 dimerization interface [polypeptide binding]; other site 345219001493 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219001494 DNA binding site [nucleotide binding] 345219001495 4Fe-4S binding domain; Region: Fer4; cl02805 345219001496 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 345219001497 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 345219001498 putative ligand binding residues [chemical binding]; other site 345219001499 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 345219001500 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 345219001501 Walker A/P-loop; other site 345219001502 ATP binding site [chemical binding]; other site 345219001503 Q-loop/lid; other site 345219001504 ABC transporter signature motif; other site 345219001505 Walker B; other site 345219001506 D-loop; other site 345219001507 H-loop/switch region; other site 345219001508 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 345219001509 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 345219001510 ABC-ATPase subunit interface; other site 345219001511 dimer interface [polypeptide binding]; other site 345219001512 putative PBP binding regions; other site 345219001513 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 345219001514 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 345219001515 ABC-ATPase subunit interface; other site 345219001516 dimer interface [polypeptide binding]; other site 345219001517 putative PBP binding regions; other site 345219001518 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 345219001519 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 345219001520 C-terminal peptidase (prc); Region: prc; TIGR00225 345219001521 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 345219001522 protein binding site [polypeptide binding]; other site 345219001523 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 345219001524 Catalytic dyad [active] 345219001525 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 345219001526 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 345219001527 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 345219001528 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 345219001529 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 345219001530 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 345219001531 homodimer interface [polypeptide binding]; other site 345219001532 substrate-cofactor binding pocket; other site 345219001533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219001534 catalytic residue [active] 345219001535 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 345219001536 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 345219001537 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 345219001538 putative active site [active] 345219001539 catalytic site [active] 345219001540 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 345219001541 putative active site [active] 345219001542 catalytic site [active] 345219001543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 345219001544 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 345219001545 Peptidase family M23; Region: Peptidase_M23; pfam01551 345219001546 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 345219001547 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 345219001548 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 345219001549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219001550 Walker A/P-loop; other site 345219001551 ATP binding site [chemical binding]; other site 345219001552 Q-loop/lid; other site 345219001553 ABC transporter signature motif; other site 345219001554 Walker B; other site 345219001555 D-loop; other site 345219001556 H-loop/switch region; other site 345219001557 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 345219001558 Uncharacterized conserved protein [Function unknown]; Region: COG1284 345219001559 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219001560 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219001561 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 345219001562 peptide chain release factor 2; Provisional; Region: PRK06746 345219001563 This domain is found in peptide chain release factors; Region: PCRF; smart00937 345219001564 RF-1 domain; Region: RF-1; pfam00472 345219001565 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 345219001566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219001567 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 345219001568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 345219001569 nucleotide binding region [chemical binding]; other site 345219001570 ATP-binding site [chemical binding]; other site 345219001571 SEC-C motif; Region: SEC-C; pfam02810 345219001572 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 345219001573 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 345219001574 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 345219001575 30S subunit binding site; other site 345219001576 Flagellar protein FliT; Region: FliT; pfam05400 345219001577 Flagellar protein FliS; Region: FliS; cl00654 345219001578 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 345219001579 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 345219001580 FlaG protein; Region: FlaG; cl00591 345219001581 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 345219001582 active site 345219001583 DNA binding site [nucleotide binding] 345219001584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219001585 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219001586 Probable transposase; Region: OrfB_IS605; pfam01385 345219001587 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 345219001588 AAA domain; Region: AAA_32; pfam13654 345219001589 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 345219001590 flagellin; Reviewed; Region: PRK08869 345219001591 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 345219001592 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 345219001593 carbon storage regulator; Provisional; Region: PRK01712 345219001594 flagellar assembly protein FliW; Provisional; Region: PRK13285 345219001595 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 345219001596 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 345219001597 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 345219001598 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 345219001599 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 345219001600 FlgN protein; Region: FlgN; pfam05130 345219001601 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 345219001602 flagellar operon protein TIGR03826; Region: YvyF 345219001603 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 345219001604 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219001605 active site 345219001606 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 345219001607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219001608 ATP binding site [chemical binding]; other site 345219001609 putative Mg++ binding site [ion binding]; other site 345219001610 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219001611 nucleotide binding region [chemical binding]; other site 345219001612 ATP-binding site [chemical binding]; other site 345219001613 EDD domain protein, DegV family; Region: DegV; TIGR00762 345219001614 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 345219001615 amino acid transporter; Region: 2A0306; TIGR00909 345219001616 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 345219001617 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 345219001618 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 345219001619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219001620 active site 345219001621 phosphorylation site [posttranslational modification] 345219001622 intermolecular recognition site; other site 345219001623 dimerization interface [polypeptide binding]; other site 345219001624 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 345219001625 DNA binding residues [nucleotide binding] 345219001626 dimerization interface [polypeptide binding]; other site 345219001627 Sensor protein DegS; Region: DegS; pfam05384 345219001628 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 345219001629 Histidine kinase; Region: HisKA_3; pfam07730 345219001630 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219001631 ATP binding site [chemical binding]; other site 345219001632 Mg2+ binding site [ion binding]; other site 345219001633 G-X-G motif; other site 345219001634 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 345219001635 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 345219001636 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 345219001637 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 345219001638 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 345219001639 Mg++ binding site [ion binding]; other site 345219001640 putative catalytic motif [active] 345219001641 substrate binding site [chemical binding]; other site 345219001642 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 345219001643 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 345219001644 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 345219001645 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 345219001646 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219001647 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219001648 dimer interface [polypeptide binding]; other site 345219001649 putative CheW interface [polypeptide binding]; other site 345219001650 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219001651 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219001652 LysM domain; Region: LysM; pfam01476 345219001653 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219001654 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 345219001655 NlpC/P60 family; Region: NLPC_P60; pfam00877 345219001656 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 345219001657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219001658 DNA-binding site [nucleotide binding]; DNA binding site 345219001659 UTRA domain; Region: UTRA; pfam07702 345219001660 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 345219001661 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 345219001662 active site 345219001663 trimer interface [polypeptide binding]; other site 345219001664 allosteric site; other site 345219001665 active site lid [active] 345219001666 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 345219001667 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 345219001668 active site 345219001669 dimer interface [polypeptide binding]; other site 345219001670 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 345219001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219001672 putative substrate translocation pore; other site 345219001673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219001674 Homoserine O-succinyltransferase; Region: HTS; pfam04204 345219001675 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 345219001676 proposed active site lysine [active] 345219001677 conserved cys residue [active] 345219001678 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 345219001679 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 345219001680 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 345219001681 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 345219001682 putative metal binding site [ion binding]; other site 345219001683 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 345219001684 S1 domain; Region: S1_2; pfam13509 345219001685 Cold-inducible protein YdjO; Region: YdjO; pfam14169 345219001686 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 345219001687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219001688 DNA binding site [nucleotide binding] 345219001689 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 345219001690 putative dimerization interface [polypeptide binding]; other site 345219001691 putative ligand binding site [chemical binding]; other site 345219001692 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 345219001693 active site 345219001694 catalytic residues [active] 345219001695 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 345219001696 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 345219001697 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 345219001698 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 345219001699 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 345219001700 NAD binding site [chemical binding]; other site 345219001701 homodimer interface [polypeptide binding]; other site 345219001702 active site 345219001703 substrate binding site [chemical binding]; other site 345219001704 galactokinase; Provisional; Region: PRK05322 345219001705 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 345219001706 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 345219001707 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 345219001708 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 345219001709 active site 345219001710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219001711 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 345219001712 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 345219001713 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219001714 active site 345219001715 motif I; other site 345219001716 motif II; other site 345219001717 Transport protein; Region: actII; TIGR00833 345219001718 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 345219001719 Transcriptional regulators [Transcription]; Region: MarR; COG1846 345219001720 MarR family; Region: MarR_2; pfam12802 345219001721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219001722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219001723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219001724 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219001725 putative substrate translocation pore; other site 345219001726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219001727 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 345219001728 Spore germination protein; Region: Spore_permease; cl17796 345219001729 aminotransferase; Validated; Region: PRK07678 345219001730 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219001731 inhibitor-cofactor binding pocket; inhibition site 345219001732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219001733 catalytic residue [active] 345219001734 nucleobase-cation-symport-1 (NCS1) transporter Mhp1-like; solute-binding domain; Region: SLC-NCS1sbd_Mhp1-like; cd11483 345219001735 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 345219001736 Na binding site [ion binding]; other site 345219001737 substrate binding site [chemical binding]; other site 345219001738 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 345219001739 allantoinase; Region: allantoinase; TIGR03178 345219001740 active site 345219001741 Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512 345219001742 Putative transcription activator [Transcription]; Region: TenA; COG0819 345219001743 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 345219001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219001745 Methyltransferase domain; Region: Methyltransf_31; pfam13847 345219001746 S-adenosylmethionine binding site [chemical binding]; other site 345219001747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219001748 non-specific DNA binding site [nucleotide binding]; other site 345219001749 salt bridge; other site 345219001750 sequence-specific DNA binding site [nucleotide binding]; other site 345219001751 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 345219001752 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 345219001753 DNA methylase; Region: N6_N4_Mtase; pfam01555 345219001754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219001755 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 345219001756 ATP binding site [chemical binding]; other site 345219001757 putative Mg++ binding site [ion binding]; other site 345219001758 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 345219001759 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 345219001760 putative active site [active] 345219001761 putative NTP binding site [chemical binding]; other site 345219001762 putative nucleic acid binding site [nucleotide binding]; other site 345219001763 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 345219001764 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 345219001765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219001766 S-adenosylmethionine binding site [chemical binding]; other site 345219001767 acyl carrier protein; Provisional; Region: acpP; PRK00982 345219001768 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 345219001769 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 345219001770 Melibiase; Region: Melibiase; pfam02065 345219001771 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 345219001772 aspartate aminotransferase; Provisional; Region: PRK06836 345219001773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219001774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219001775 homodimer interface [polypeptide binding]; other site 345219001776 catalytic residue [active] 345219001777 Protein of unknown function (DUF4004); Region: DUF4004; pfam13171 345219001778 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 345219001779 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 345219001780 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 345219001781 MATE family multidrug exporter; Provisional; Region: PRK10189 345219001782 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 345219001783 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 345219001784 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 345219001785 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 345219001786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219001787 AAA domain; Region: AAA_27; pfam13514 345219001788 Walker A/P-loop; other site 345219001789 ATP binding site [chemical binding]; other site 345219001790 Q-loop/lid; other site 345219001791 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 345219001792 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 345219001793 active site 345219001794 metal binding site [ion binding]; metal-binding site 345219001795 DNA binding site [nucleotide binding] 345219001796 Predicted flavoprotein [General function prediction only]; Region: COG0431 345219001797 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 345219001798 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219001799 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219001800 active site 345219001801 catalytic tetrad [active] 345219001802 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 345219001803 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 345219001804 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 345219001805 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219001806 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219001807 active site 345219001808 catalytic tetrad [active] 345219001809 hypothetical protein; Provisional; Region: PRK06922 345219001810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219001811 S-adenosylmethionine binding site [chemical binding]; other site 345219001812 Esterase/lipase [General function prediction only]; Region: COG1647 345219001813 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 345219001814 Protein of unknown function (DUF3940); Region: DUF3940; pfam13076 345219001815 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219001816 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 345219001817 active site 345219001818 motif I; other site 345219001819 motif II; other site 345219001820 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 345219001821 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 345219001822 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 345219001823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219001824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219001825 DNA binding site [nucleotide binding] 345219001826 domain linker motif; other site 345219001827 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 345219001828 putative dimerization interface [polypeptide binding]; other site 345219001829 putative ligand binding site [chemical binding]; other site 345219001830 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 345219001831 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 345219001832 inhibitor binding site; inhibition site 345219001833 catalytic Zn binding site [ion binding]; other site 345219001834 structural Zn binding site [ion binding]; other site 345219001835 NADP binding site [chemical binding]; other site 345219001836 tetramer interface [polypeptide binding]; other site 345219001837 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 345219001838 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219001839 FeS/SAM binding site; other site 345219001840 YfkB-like domain; Region: YfkB; pfam08756 345219001841 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 345219001842 Ligand Binding Site [chemical binding]; other site 345219001843 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 345219001844 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 345219001845 short chain dehydrogenase; Provisional; Region: PRK06701 345219001846 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 345219001847 NAD binding site [chemical binding]; other site 345219001848 metal binding site [ion binding]; metal-binding site 345219001849 active site 345219001850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 345219001851 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219001852 active site 345219001853 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 345219001854 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 345219001855 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 345219001856 acyl-activating enzyme (AAE) consensus motif; other site 345219001857 putative AMP binding site [chemical binding]; other site 345219001858 putative active site [active] 345219001859 putative CoA binding site [chemical binding]; other site 345219001860 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 345219001861 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 345219001862 DNA binding residues [nucleotide binding] 345219001863 putative dimer interface [polypeptide binding]; other site 345219001864 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 345219001865 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 345219001866 active site 345219001867 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 345219001868 NlpC/P60 family; Region: NLPC_P60; pfam00877 345219001869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219001870 DEAD-like helicases superfamily; Region: DEXDc; smart00487 345219001871 ATP binding site [chemical binding]; other site 345219001872 putative Mg++ binding site [ion binding]; other site 345219001873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219001874 nucleotide binding region [chemical binding]; other site 345219001875 ATP-binding site [chemical binding]; other site 345219001876 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 345219001877 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 345219001878 putative catalytic cysteine [active] 345219001879 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 345219001880 putative active site [active] 345219001881 metal binding site [ion binding]; metal-binding site 345219001882 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 345219001883 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 345219001884 Cl binding site [ion binding]; other site 345219001885 oligomer interface [polypeptide binding]; other site 345219001886 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 345219001887 Na binding site [ion binding]; other site 345219001888 Protein of unknown function (DUF997); Region: DUF997; pfam06196 345219001889 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 345219001890 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 345219001891 active site 345219001892 tetramer interface; other site 345219001893 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 345219001894 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 345219001895 putative substrate binding site [chemical binding]; other site 345219001896 putative ATP binding site [chemical binding]; other site 345219001897 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219001898 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 345219001899 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 345219001900 active site 345219001901 metal binding site [ion binding]; metal-binding site 345219001902 homoserine dehydrogenase; Provisional; Region: PRK06349 345219001903 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 345219001904 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 345219001905 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 345219001906 threonine synthase; Reviewed; Region: PRK06721 345219001907 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 345219001908 homodimer interface [polypeptide binding]; other site 345219001909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219001910 catalytic residue [active] 345219001911 homoserine kinase; Provisional; Region: PRK01212 345219001912 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 345219001913 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 345219001914 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 345219001915 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 345219001916 Walker A/P-loop; other site 345219001917 ATP binding site [chemical binding]; other site 345219001918 Q-loop/lid; other site 345219001919 ABC transporter signature motif; other site 345219001920 Walker B; other site 345219001921 D-loop; other site 345219001922 H-loop/switch region; other site 345219001923 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 345219001924 NMT1/THI5 like; Region: NMT1; pfam09084 345219001925 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 345219001926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219001927 dimer interface [polypeptide binding]; other site 345219001928 conserved gate region; other site 345219001929 putative PBP binding loops; other site 345219001930 ABC-ATPase subunit interface; other site 345219001931 Domain of unknown function DUF77; Region: DUF77; pfam01910 345219001932 amidase; Provisional; Region: PRK06529 345219001933 Amidase; Region: Amidase; cl11426 345219001934 Heat induced stress protein YflT; Region: YflT; pfam11181 345219001935 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 345219001936 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 345219001937 tetramer interface [polypeptide binding]; other site 345219001938 active site 345219001939 Mg2+/Mn2+ binding site [ion binding]; other site 345219001940 2-methylcitrate dehydratase; Region: prpD; TIGR02330 345219001941 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 345219001942 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 345219001943 dimer interface [polypeptide binding]; other site 345219001944 Citrate synthase; Region: Citrate_synt; pfam00285 345219001945 active site 345219001946 coenzyme A binding site [chemical binding]; other site 345219001947 citrylCoA binding site [chemical binding]; other site 345219001948 oxalacetate/citrate binding site [chemical binding]; other site 345219001949 catalytic triad [active] 345219001950 Domain of unknown function (DUF956); Region: DUF956; pfam06115 345219001951 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 345219001952 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 345219001953 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 345219001954 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 345219001955 active pocket/dimerization site; other site 345219001956 active site 345219001957 phosphorylation site [posttranslational modification] 345219001958 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 345219001959 active site 345219001960 phosphorylation site [posttranslational modification] 345219001961 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 345219001962 active site 345219001963 phosphorylation site [posttranslational modification] 345219001964 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 345219001965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219001966 Walker A motif; other site 345219001967 ATP binding site [chemical binding]; other site 345219001968 Walker B motif; other site 345219001969 arginine finger; other site 345219001970 Transcriptional antiterminator [Transcription]; Region: COG3933 345219001971 PRD domain; Region: PRD; pfam00874 345219001972 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 345219001973 active pocket/dimerization site; other site 345219001974 active site 345219001975 phosphorylation site [posttranslational modification] 345219001976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219001977 binding surface 345219001978 TPR motif; other site 345219001979 Dynamin family; Region: Dynamin_N; pfam00350 345219001980 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 345219001981 G3 box; other site 345219001982 Switch II region; other site 345219001983 GTP/Mg2+ binding site [chemical binding]; other site 345219001984 G4 box; other site 345219001985 G5 box; other site 345219001986 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 345219001987 Domain of unknown function DUF77; Region: DUF77; pfam01910 345219001988 Predicted membrane protein [Function unknown]; Region: COG1511 345219001989 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 345219001990 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 345219001991 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 345219001992 HD domain; Region: HD_4; pfam13328 345219001993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 345219001994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 345219001995 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 345219001996 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 345219001997 tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219001998 NAD binding site [chemical binding]; other site 345219001999 dimer interface [polypeptide binding]; other site 345219002000 substrate binding site [chemical binding]; other site 345219002001 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 345219002002 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 345219002003 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 345219002004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219002005 dimer interface [polypeptide binding]; other site 345219002006 phosphorylation site [posttranslational modification] 345219002007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219002008 ATP binding site [chemical binding]; other site 345219002009 Mg2+ binding site [ion binding]; other site 345219002010 G-X-G motif; other site 345219002011 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219002012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219002013 active site 345219002014 phosphorylation site [posttranslational modification] 345219002015 intermolecular recognition site; other site 345219002016 dimerization interface [polypeptide binding]; other site 345219002017 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219002018 DNA binding site [nucleotide binding] 345219002019 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 345219002020 FtsX-like permease family; Region: FtsX; pfam02687 345219002021 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 345219002022 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 345219002023 Walker A/P-loop; other site 345219002024 ATP binding site [chemical binding]; other site 345219002025 Q-loop/lid; other site 345219002026 ABC transporter signature motif; other site 345219002027 Walker B; other site 345219002028 D-loop; other site 345219002029 H-loop/switch region; other site 345219002030 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 345219002031 HlyD family secretion protein; Region: HlyD_3; pfam13437 345219002032 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 345219002033 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 345219002034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219002035 motif II; other site 345219002036 cytochrome aa3 quinol oxidase, subunit II; Region: QOXA; TIGR01432 345219002037 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 345219002038 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 345219002039 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 345219002040 D-pathway; other site 345219002041 Putative ubiquinol binding site [chemical binding]; other site 345219002042 Low-spin heme (heme b) binding site [chemical binding]; other site 345219002043 Putative water exit pathway; other site 345219002044 Binuclear center (heme o3/CuB) [ion binding]; other site 345219002045 K-pathway; other site 345219002046 Putative proton exit pathway; other site 345219002047 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 345219002048 Subunit I/III interface [polypeptide binding]; other site 345219002049 Subunit III/IV interface [polypeptide binding]; other site 345219002050 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 345219002051 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 345219002052 classical (c) SDRs; Region: SDR_c; cd05233 345219002053 NAD(P) binding site [chemical binding]; other site 345219002054 active site 345219002055 teichoic acids export protein ATP-binding subunit; Provisional; Region: PRK13546 345219002056 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 345219002057 Walker A/P-loop; other site 345219002058 ATP binding site [chemical binding]; other site 345219002059 Q-loop/lid; other site 345219002060 ABC transporter signature motif; other site 345219002061 Walker B; other site 345219002062 D-loop; other site 345219002063 H-loop/switch region; other site 345219002064 Predicted integral membrane protein [Function unknown]; Region: COG5652 345219002065 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 345219002066 putative active site [active] 345219002067 catalytic triad [active] 345219002068 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 345219002069 PA/protease domain interface [polypeptide binding]; other site 345219002070 putative integrin binding motif; other site 345219002071 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 345219002072 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 345219002073 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 345219002074 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 345219002075 active site 345219002076 substrate binding site [chemical binding]; other site 345219002077 metal binding site [ion binding]; metal-binding site 345219002078 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 345219002079 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 345219002080 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 345219002081 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 345219002082 NAD(P) binding site [chemical binding]; other site 345219002083 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 345219002084 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 345219002085 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 345219002086 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 345219002087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219002088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219002089 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 345219002090 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 345219002091 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 345219002092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002093 dimer interface [polypeptide binding]; other site 345219002094 conserved gate region; other site 345219002095 putative PBP binding loops; other site 345219002096 ABC-ATPase subunit interface; other site 345219002097 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 345219002098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 345219002099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002100 dimer interface [polypeptide binding]; other site 345219002101 conserved gate region; other site 345219002102 putative PBP binding loops; other site 345219002103 ABC-ATPase subunit interface; other site 345219002104 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 345219002105 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 345219002106 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 345219002107 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 345219002108 cystathionine beta-lyase; Provisional; Region: PRK08064 345219002109 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 345219002110 homodimer interface [polypeptide binding]; other site 345219002111 substrate-cofactor binding pocket; other site 345219002112 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219002113 catalytic residue [active] 345219002114 cystathionine gamma-synthase; Reviewed; Region: PRK08247 345219002115 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 345219002116 homodimer interface [polypeptide binding]; other site 345219002117 substrate-cofactor binding pocket; other site 345219002118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219002119 catalytic residue [active] 345219002120 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219002121 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219002122 Walker A/P-loop; other site 345219002123 ATP binding site [chemical binding]; other site 345219002124 Q-loop/lid; other site 345219002125 ABC transporter signature motif; other site 345219002126 Walker B; other site 345219002127 D-loop; other site 345219002128 H-loop/switch region; other site 345219002129 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 345219002130 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 345219002131 putative active site [active] 345219002132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 345219002133 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 345219002134 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 345219002135 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 345219002136 HTH domain; Region: HTH_11; pfam08279 345219002137 Mga helix-turn-helix domain; Region: Mga; pfam05043 345219002138 PRD domain; Region: PRD; pfam00874 345219002139 PRD domain; Region: PRD; pfam00874 345219002140 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 345219002141 active site 345219002142 P-loop; other site 345219002143 phosphorylation site [posttranslational modification] 345219002144 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 345219002145 active site 345219002146 phosphorylation site [posttranslational modification] 345219002147 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 345219002148 beta-galactosidase; Region: BGL; TIGR03356 345219002149 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 345219002150 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 345219002151 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 345219002152 active site 345219002153 P-loop; other site 345219002154 phosphorylation site [posttranslational modification] 345219002155 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 345219002156 methionine cluster; other site 345219002157 active site 345219002158 phosphorylation site [posttranslational modification] 345219002159 metal binding site [ion binding]; metal-binding site 345219002160 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 345219002161 Peptidase M30; Region: Peptidase_M30; pfam10460 345219002162 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 345219002163 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 345219002164 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 345219002165 YvrJ protein family; Region: YvrJ; pfam12841 345219002166 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 345219002167 tartrate dehydrogenase; Provisional; Region: PRK08194 345219002168 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219002169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002170 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002171 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 345219002172 aspartate aminotransferase; Provisional; Region: PRK06836 345219002173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219002174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219002175 homodimer interface [polypeptide binding]; other site 345219002176 catalytic residue [active] 345219002177 Transcriptional regulators [Transcription]; Region: FadR; COG2186 345219002178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219002179 DNA-binding site [nucleotide binding]; DNA binding site 345219002180 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 345219002181 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 345219002182 L-lactate permease; Region: Lactate_perm; cl00701 345219002183 Arv1-like family; Region: Arv1; pfam04161 345219002184 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 345219002185 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 345219002186 Response regulator receiver domain; Region: Response_reg; pfam00072 345219002187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219002188 active site 345219002189 phosphorylation site [posttranslational modification] 345219002190 intermolecular recognition site; other site 345219002191 dimerization interface [polypeptide binding]; other site 345219002192 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219002193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 345219002194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219002195 Histidine kinase; Region: His_kinase; pfam06580 345219002196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219002197 ATP binding site [chemical binding]; other site 345219002198 Mg2+ binding site [ion binding]; other site 345219002199 G-X-G motif; other site 345219002200 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219002201 LXG domain of WXG superfamily; Region: LXG; pfam04740 345219002202 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 345219002203 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 345219002204 oligomer interface [polypeptide binding]; other site 345219002205 active site 345219002206 metal binding site [ion binding]; metal-binding site 345219002207 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 345219002208 Enoate reductase (ER)-like FMN-binding domain. Enoate reductase catalyzes the NADH-dependent reduction of carbon-carbon double bonds of several molecules, including nonactivated 2-enoates, alpha,beta-unsaturated aldehydes, cyclic ketones, and...; Region: ER_like_FMN; cd02931 345219002209 putative active site [active] 345219002210 putative FMN binding site [chemical binding]; other site 345219002211 putative substrate binding site [chemical binding]; other site 345219002212 putative catalytic residue [active] 345219002213 putative 4Fe-4S cluster binding site [ion binding]; other site 345219002214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 345219002215 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219002216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219002217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219002218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219002219 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 345219002220 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 345219002221 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 345219002222 acyl-activating enzyme (AAE) consensus motif; other site 345219002223 putative AMP binding site [chemical binding]; other site 345219002224 putative active site [active] 345219002225 putative CoA binding site [chemical binding]; other site 345219002226 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219002227 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 345219002228 active site 345219002229 Protein of unknown function (DUF1192); Region: DUF1192; pfam06698 345219002230 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 345219002231 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 345219002232 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 345219002233 putative active site [active] 345219002234 putative catalytic site [active] 345219002235 FOG: CBS domain [General function prediction only]; Region: COG0517 345219002236 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 345219002237 PAS domain S-box; Region: sensory_box; TIGR00229 345219002238 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219002239 putative active site [active] 345219002240 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 345219002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219002242 Walker A motif; other site 345219002243 ATP binding site [chemical binding]; other site 345219002244 Walker B motif; other site 345219002245 arginine finger; other site 345219002246 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219002247 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 345219002248 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH6; cd08194 345219002249 putative active site [active] 345219002250 metal binding site [ion binding]; metal-binding site 345219002251 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 345219002252 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 345219002253 tetrameric interface [polypeptide binding]; other site 345219002254 NAD binding site [chemical binding]; other site 345219002255 catalytic residues [active] 345219002256 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 345219002257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219002258 NAD(P) binding site [chemical binding]; other site 345219002259 active site 345219002260 Uncharacterized conserved protein [Function unknown]; Region: COG1912 345219002261 hypothetical protein; Provisional; Region: PRK13661 345219002262 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 345219002263 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 345219002264 Walker A/P-loop; other site 345219002265 ATP binding site [chemical binding]; other site 345219002266 Q-loop/lid; other site 345219002267 ABC transporter signature motif; other site 345219002268 Walker B; other site 345219002269 D-loop; other site 345219002270 H-loop/switch region; other site 345219002271 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 345219002272 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 345219002273 Walker A/P-loop; other site 345219002274 ATP binding site [chemical binding]; other site 345219002275 Q-loop/lid; other site 345219002276 ABC transporter signature motif; other site 345219002277 Walker B; other site 345219002278 D-loop; other site 345219002279 H-loop/switch region; other site 345219002280 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 345219002281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219002282 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219002283 dimer interface [polypeptide binding]; other site 345219002284 putative CheW interface [polypeptide binding]; other site 345219002285 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 345219002286 Uncharacterized conserved protein [Function unknown]; Region: COG1432 345219002287 LabA_like proteins; Region: LabA_like; cd06167 345219002288 putative metal binding site [ion binding]; other site 345219002289 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 345219002290 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 345219002291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 345219002292 catalytic residue [active] 345219002293 L-aspartate oxidase; Provisional; Region: PRK08071 345219002294 L-aspartate oxidase; Provisional; Region: PRK06175 345219002295 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 345219002296 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK08072 345219002297 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 345219002298 dimerization interface [polypeptide binding]; other site 345219002299 active site 345219002300 quinolinate synthetase; Provisional; Region: PRK09375 345219002301 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 345219002302 putative DNA binding site [nucleotide binding]; other site 345219002303 putative Zn2+ binding site [ion binding]; other site 345219002304 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 345219002305 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 345219002306 nucleotide binding site [chemical binding]; other site 345219002307 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 345219002308 xylose isomerase; Provisional; Region: PRK05474 345219002309 xylose isomerase; Region: xylose_isom_A; TIGR02630 345219002310 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 345219002311 N- and C-terminal domain interface [polypeptide binding]; other site 345219002312 D-xylulose kinase; Region: XylB; TIGR01312 345219002313 active site 345219002314 MgATP binding site [chemical binding]; other site 345219002315 catalytic site [active] 345219002316 metal binding site [ion binding]; metal-binding site 345219002317 xylulose binding site [chemical binding]; other site 345219002318 homodimer interface [polypeptide binding]; other site 345219002319 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 345219002320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002321 putative substrate translocation pore; other site 345219002322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002323 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 345219002324 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 345219002325 putative active site [active] 345219002326 metal binding site [ion binding]; metal-binding site 345219002327 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219002328 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 345219002329 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 345219002330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219002331 Walker A motif; other site 345219002332 ATP binding site [chemical binding]; other site 345219002333 Walker B motif; other site 345219002334 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 345219002335 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 345219002336 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 345219002337 substrate binding pocket [chemical binding]; other site 345219002338 catalytic triad [active] 345219002339 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 345219002340 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 345219002341 active site 345219002342 catalytic triad [active] 345219002343 oxyanion hole [active] 345219002344 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 345219002345 short chain dehydrogenase; Provisional; Region: PRK07109 345219002346 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 345219002347 putative NAD(P) binding site [chemical binding]; other site 345219002348 active site 345219002349 maltose O-acetyltransferase; Provisional; Region: PRK10092 345219002350 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 345219002351 active site 345219002352 substrate binding site [chemical binding]; other site 345219002353 trimer interface [polypeptide binding]; other site 345219002354 CoA binding site [chemical binding]; other site 345219002355 Predicted transcriptional regulators [Transcription]; Region: COG1510 345219002356 MarR family; Region: MarR_2; pfam12802 345219002357 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 345219002358 glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186 345219002359 Walker A/P-loop; other site 345219002360 ATP binding site [chemical binding]; other site 345219002361 Q-loop/lid; other site 345219002362 ABC transporter signature motif; other site 345219002363 Walker B; other site 345219002364 D-loop; other site 345219002365 H-loop/switch region; other site 345219002366 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 345219002367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002368 dimer interface [polypeptide binding]; other site 345219002369 conserved gate region; other site 345219002370 putative PBP binding loops; other site 345219002371 ABC-ATPase subunit interface; other site 345219002372 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 345219002373 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 345219002374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002375 dimer interface [polypeptide binding]; other site 345219002376 conserved gate region; other site 345219002377 putative PBP binding loops; other site 345219002378 ABC-ATPase subunit interface; other site 345219002379 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 345219002380 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 345219002381 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 345219002382 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 345219002383 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 345219002384 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219002385 DNA binding site [nucleotide binding] 345219002386 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 345219002387 putative dimerization interface [polypeptide binding]; other site 345219002388 putative ligand binding site [chemical binding]; other site 345219002389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219002391 putative substrate translocation pore; other site 345219002392 Transcriptional regulators [Transcription]; Region: MarR; COG1846 345219002393 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219002394 putative Zn2+ binding site [ion binding]; other site 345219002395 putative DNA binding site [nucleotide binding]; other site 345219002396 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 345219002397 L-threonine dehydrogenase, extended (e) SDRs; Region: TDH_SDR_e; cd05272 345219002398 NAD binding site [chemical binding]; other site 345219002399 homodimer interface [polypeptide binding]; other site 345219002400 active site 345219002401 putative substrate binding site [chemical binding]; other site 345219002402 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 345219002403 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 345219002404 substrate-cofactor binding pocket; other site 345219002405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219002406 catalytic residue [active] 345219002407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 345219002408 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 345219002409 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 345219002410 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 345219002411 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 345219002412 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 345219002413 Uncharacterized conserved protein [Function unknown]; Region: COG3589 345219002414 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 345219002415 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 345219002416 active site 345219002417 methionine cluster; other site 345219002418 phosphorylation site [posttranslational modification] 345219002419 metal binding site [ion binding]; metal-binding site 345219002420 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 345219002421 active site 345219002422 P-loop; other site 345219002423 phosphorylation site [posttranslational modification] 345219002424 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 345219002425 HTH domain; Region: HTH_11; pfam08279 345219002426 Mga helix-turn-helix domain; Region: Mga; pfam05043 345219002427 PRD domain; Region: PRD; pfam00874 345219002428 PRD domain; Region: PRD; pfam00874 345219002429 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 345219002430 active site 345219002431 P-loop; other site 345219002432 phosphorylation site [posttranslational modification] 345219002433 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 345219002434 active site 345219002435 phosphorylation site [posttranslational modification] 345219002436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002437 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219002438 putative substrate translocation pore; other site 345219002439 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 345219002440 Prostaglandin dehydrogenases; Region: PGDH; cd05288 345219002441 NAD(P) binding site [chemical binding]; other site 345219002442 substrate binding site [chemical binding]; other site 345219002443 dimer interface [polypeptide binding]; other site 345219002444 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 345219002445 CoA-transferase family III; Region: CoA_transf_3; pfam02515 345219002446 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 345219002447 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219002448 active site 345219002449 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 345219002450 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219002451 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219002452 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 345219002453 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219002454 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219002455 active site 345219002456 catalytic tetrad [active] 345219002457 Transcriptional regulator [Transcription]; Region: LytR; COG1316 345219002458 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 345219002459 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 345219002460 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 345219002461 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 345219002462 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 345219002463 Radical SAM superfamily; Region: Radical_SAM; pfam04055 345219002464 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 345219002465 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 345219002466 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 345219002467 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 345219002468 Protein of unknown function (DUF419); Region: DUF419; pfam04237 345219002469 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 345219002470 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 345219002471 FMN binding site [chemical binding]; other site 345219002472 substrate binding site [chemical binding]; other site 345219002473 putative catalytic residue [active] 345219002474 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 345219002475 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 345219002476 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 345219002477 Uncharacterized conserved protein [Function unknown]; Region: COG3535 345219002478 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 345219002479 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 345219002480 Na binding site [ion binding]; other site 345219002481 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 345219002482 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 345219002483 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 345219002484 Protein of unknown function (DUF917); Region: DUF917; cl17829 345219002485 PAS domain; Region: PAS; smart00091 345219002486 PAS domain; Region: PAS_9; pfam13426 345219002487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219002488 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 345219002489 Walker A motif; other site 345219002490 ATP binding site [chemical binding]; other site 345219002491 Walker B motif; other site 345219002492 arginine finger; other site 345219002493 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219002494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219002495 ABC transporter signature motif; other site 345219002496 Walker B; other site 345219002497 D-loop; other site 345219002498 H-loop/switch region; other site 345219002499 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 345219002500 YfzA-like protein; Region: YfzA; pfam14118 345219002501 HipA N-terminal domain; Region: Couple_hipA; cl11853 345219002502 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 345219002503 HipA-like C-terminal domain; Region: HipA_C; pfam07804 345219002504 Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell envelope biogenesis, outer membrane]; Region: GlmS; COG0449 345219002505 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 345219002506 dimer interface [polypeptide binding]; other site 345219002507 active site 345219002508 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 345219002509 dimer interface [polypeptide binding]; other site 345219002510 active site 345219002511 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 345219002512 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 345219002513 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 345219002514 active site 345219002515 phosphorylation site [posttranslational modification] 345219002516 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 345219002517 active pocket/dimerization site; other site 345219002518 active site 345219002519 phosphorylation site [posttranslational modification] 345219002520 PRD domain; Region: PRD; pfam00874 345219002521 Winged helix-turn helix; Region: HTH_29; pfam13551 345219002522 Helix-turn-helix domain; Region: HTH_28; pfam13518 345219002523 Homeodomain-like domain; Region: HTH_32; pfam13565 345219002524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 345219002525 Integrase core domain; Region: rve; pfam00665 345219002526 Integrase core domain; Region: rve_3; cl15866 345219002527 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 345219002528 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 345219002529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219002530 Walker A motif; other site 345219002531 ATP binding site [chemical binding]; other site 345219002532 Walker B motif; other site 345219002533 arginine finger; other site 345219002534 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 345219002535 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219002536 Walker A motif; other site 345219002537 ATP binding site [chemical binding]; other site 345219002538 Walker B motif; other site 345219002539 arginine finger; other site 345219002540 PRD domain; Region: PRD; pfam00874 345219002541 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 345219002542 active pocket/dimerization site; other site 345219002543 active site 345219002544 phosphorylation site [posttranslational modification] 345219002545 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 345219002546 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 345219002547 Na binding site [ion binding]; other site 345219002548 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 345219002549 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 345219002550 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 345219002551 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 345219002552 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 345219002553 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 345219002554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219002555 non-specific DNA binding site [nucleotide binding]; other site 345219002556 salt bridge; other site 345219002557 sequence-specific DNA binding site [nucleotide binding]; other site 345219002558 Cupin domain; Region: Cupin_2; pfam07883 345219002559 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 345219002560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219002561 DNA-binding site [nucleotide binding]; DNA binding site 345219002562 UTRA domain; Region: UTRA; pfam07702 345219002563 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 345219002564 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 345219002565 active site 345219002566 trimer interface [polypeptide binding]; other site 345219002567 allosteric site; other site 345219002568 active site lid [active] 345219002569 hexamer (dimer of trimers) interface [polypeptide binding]; other site 345219002570 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 345219002571 active site 345219002572 phosphorylation site [posttranslational modification] 345219002573 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 345219002574 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 345219002575 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 345219002576 active pocket/dimerization site; other site 345219002577 active site 345219002578 phosphorylation site [posttranslational modification] 345219002579 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 345219002580 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219002581 Methyltransferase domain; Region: Methyltransf_31; pfam13847 345219002582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219002583 S-adenosylmethionine binding site [chemical binding]; other site 345219002584 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 345219002585 Bacterial SH3 domain; Region: SH3_3; cl17532 345219002586 Bacterial SH3 domain; Region: SH3_3; cl17532 345219002587 Bacterial SH3 domain; Region: SH3_3; pfam08239 345219002588 Bacterial SH3 domain; Region: SH3_3; cl17532 345219002589 Bacterial SH3 domain; Region: SH3_3; cl17532 345219002590 Bacterial SH3 domain; Region: SH3_3; cl17532 345219002591 Bacterial SH3 domain; Region: SH3_3; pfam08239 345219002592 Bacterial SH3 domain; Region: SH3_3; pfam08239 345219002593 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 345219002594 Lysozyme subfamily 2; Region: LYZ2; smart00047 345219002595 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 345219002596 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219002597 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219002598 Probable transposase; Region: OrfB_IS605; pfam01385 345219002599 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 345219002600 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 345219002601 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 345219002602 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 345219002603 NAD binding site [chemical binding]; other site 345219002604 catalytic Zn binding site [ion binding]; other site 345219002605 structural Zn binding site [ion binding]; other site 345219002606 Peptidase M30; Region: Peptidase_M30; pfam10460 345219002607 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 345219002608 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 345219002609 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 345219002610 N- and C-terminal domain interface [polypeptide binding]; other site 345219002611 D-xylulose kinase; Region: XylB; TIGR01312 345219002612 active site 345219002613 MgATP binding site [chemical binding]; other site 345219002614 catalytic site [active] 345219002615 metal binding site [ion binding]; metal-binding site 345219002616 xylulose binding site [chemical binding]; other site 345219002617 homodimer interface [polypeptide binding]; other site 345219002618 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 345219002619 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 345219002620 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219002621 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 345219002622 amino acid transporter; Region: 2A0306; TIGR00909 345219002623 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 345219002624 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 345219002625 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 345219002626 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 345219002627 urea carboxylase; Region: urea_carbox; TIGR02712 345219002628 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219002629 ATP-grasp domain; Region: ATP-grasp_4; cl17255 345219002630 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 345219002631 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 345219002632 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 345219002633 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 345219002634 carboxyltransferase (CT) interaction site; other site 345219002635 biotinylation site [posttranslational modification]; other site 345219002636 allophanate hydrolase; Provisional; Region: PRK08186 345219002637 Amidase; Region: Amidase; cl11426 345219002638 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 345219002639 Ergosterol biosynthesis ERG4/ERG24 family; Region: ERG4_ERG24; pfam01222 345219002640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219002641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219002642 ATP binding site [chemical binding]; other site 345219002643 putative Mg++ binding site [ion binding]; other site 345219002644 nucleotide binding region [chemical binding]; other site 345219002645 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 345219002646 ATP-binding site [chemical binding]; other site 345219002647 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 345219002648 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 345219002649 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 345219002650 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 345219002651 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 345219002652 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 345219002653 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 345219002654 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 345219002655 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 345219002656 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 345219002657 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 345219002658 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 345219002659 Bacterial sugar transferase; Region: Bac_transf; pfam02397 345219002660 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 345219002661 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 345219002662 active site 345219002663 tetramer interface; other site 345219002664 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 345219002665 AAA domain; Region: AAA_31; pfam13614 345219002666 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 345219002667 Chain length determinant protein; Region: Wzz; cl15801 345219002668 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 345219002669 RNA polymerase factor sigma-70; Validated; Region: PRK06759 345219002670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219002671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219002672 DNA binding residues [nucleotide binding] 345219002673 ComK protein; Region: ComK; cl11560 345219002674 CsbD-like; Region: CsbD; pfam05532 345219002675 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 345219002676 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 345219002677 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 345219002678 substrate binding pocket [chemical binding]; other site 345219002679 dimer interface [polypeptide binding]; other site 345219002680 inhibitor binding site; inhibition site 345219002681 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 345219002682 B12 binding site [chemical binding]; other site 345219002683 cobalt ligand [ion binding]; other site 345219002684 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 345219002685 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 345219002686 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 345219002687 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 345219002688 FAD binding site [chemical binding]; other site 345219002689 Transcriptional regulator [Transcription]; Region: LytR; COG1316 345219002690 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 345219002691 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 345219002692 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 345219002693 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 345219002694 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 345219002695 active site 345219002696 Predicted transcriptional regulators [Transcription]; Region: COG1733 345219002697 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219002698 dimerization interface [polypeptide binding]; other site 345219002699 putative DNA binding site [nucleotide binding]; other site 345219002700 putative Zn2+ binding site [ion binding]; other site 345219002701 Predicted membrane protein [General function prediction only]; Region: COG4194 345219002702 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 345219002703 Predicted transcriptional regulators [Transcription]; Region: COG1725 345219002704 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219002705 DNA-binding site [nucleotide binding]; DNA binding site 345219002706 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 345219002707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002708 dimer interface [polypeptide binding]; other site 345219002709 conserved gate region; other site 345219002710 putative PBP binding loops; other site 345219002711 ABC-ATPase subunit interface; other site 345219002712 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 345219002713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002714 dimer interface [polypeptide binding]; other site 345219002715 conserved gate region; other site 345219002716 putative PBP binding loops; other site 345219002717 ABC-ATPase subunit interface; other site 345219002718 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 345219002719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219002720 substrate binding pocket [chemical binding]; other site 345219002721 membrane-bound complex binding site; other site 345219002722 hinge residues; other site 345219002723 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 345219002724 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 345219002725 Walker A/P-loop; other site 345219002726 ATP binding site [chemical binding]; other site 345219002727 Q-loop/lid; other site 345219002728 ABC transporter signature motif; other site 345219002729 Walker B; other site 345219002730 D-loop; other site 345219002731 H-loop/switch region; other site 345219002732 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 345219002733 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 345219002734 Domain of unknown function DUF20; Region: UPF0118; pfam01594 345219002735 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 345219002736 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 345219002737 Amino acid permease; Region: AA_permease_2; pfam13520 345219002738 Transposase; Region: HTH_Tnp_1; cl17663 345219002739 HTH-like domain; Region: HTH_21; pfam13276 345219002740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 345219002741 Integrase core domain; Region: rve; pfam00665 345219002742 Integrase core domain; Region: rve_3; pfam13683 345219002743 glycyl-tRNA synthetase; Provisional; Region: PRK04173 345219002744 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 345219002745 motif 1; other site 345219002746 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 345219002747 active site 345219002748 motif 2; other site 345219002749 motif 3; other site 345219002750 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 345219002751 anticodon binding site; other site 345219002752 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 345219002753 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219002754 Zn2+ binding site [ion binding]; other site 345219002755 Mg2+ binding site [ion binding]; other site 345219002756 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 345219002757 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 345219002758 putative active site [active] 345219002759 putative FMN binding site [chemical binding]; other site 345219002760 putative substrate binding site [chemical binding]; other site 345219002761 putative catalytic residue [active] 345219002762 Uncharacterized conserved protein [Function unknown]; Region: COG2353 345219002763 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 345219002764 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 345219002765 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 345219002766 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 345219002767 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 345219002768 ligand binding site [chemical binding]; other site 345219002769 flexible hinge region; other site 345219002770 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 345219002771 non-specific DNA interactions [nucleotide binding]; other site 345219002772 DNA binding site [nucleotide binding] 345219002773 sequence specific DNA binding site [nucleotide binding]; other site 345219002774 putative cAMP binding site [chemical binding]; other site 345219002775 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 345219002776 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 345219002777 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 345219002778 glycerol kinase; Provisional; Region: glpK; PRK00047 345219002779 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 345219002780 N- and C-terminal domain interface [polypeptide binding]; other site 345219002781 active site 345219002782 MgATP binding site [chemical binding]; other site 345219002783 catalytic site [active] 345219002784 metal binding site [ion binding]; metal-binding site 345219002785 glycerol binding site [chemical binding]; other site 345219002786 homotetramer interface [polypeptide binding]; other site 345219002787 homodimer interface [polypeptide binding]; other site 345219002788 FBP binding site [chemical binding]; other site 345219002789 protein IIAGlc interface [polypeptide binding]; other site 345219002790 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 345219002791 amphipathic channel; other site 345219002792 Asn-Pro-Ala signature motifs; other site 345219002793 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 345219002794 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219002795 non-specific DNA binding site [nucleotide binding]; other site 345219002796 salt bridge; other site 345219002797 sequence-specific DNA binding site [nucleotide binding]; other site 345219002798 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 345219002799 Part of AAA domain; Region: AAA_19; pfam13245 345219002800 Family description; Region: UvrD_C_2; pfam13538 345219002801 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 345219002802 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 345219002803 Ligand binding site; other site 345219002804 Putative Catalytic site; other site 345219002805 DXD motif; other site 345219002806 H+/citrate symporter [Energy production and conversion]; Region: CitM; cl17620 345219002807 Citrate transporter; Region: CitMHS; pfam03600 345219002808 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 345219002809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219002810 active site 345219002811 phosphorylation site [posttranslational modification] 345219002812 intermolecular recognition site; other site 345219002813 dimerization interface [polypeptide binding]; other site 345219002814 Transcriptional regulator; Region: CitT; pfam12431 345219002815 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 345219002816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219002817 ATP binding site [chemical binding]; other site 345219002818 Mg2+ binding site [ion binding]; other site 345219002819 G-X-G motif; other site 345219002820 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 345219002821 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 345219002822 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 345219002823 dimer interface [polypeptide binding]; other site 345219002824 active site 345219002825 metal binding site [ion binding]; metal-binding site 345219002826 Amino acid permease; Region: AA_permease_2; pfam13520 345219002827 Spore germination protein; Region: Spore_permease; cl17796 345219002828 phenylhydantoinase; Validated; Region: PRK08323 345219002829 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 345219002830 tetramer interface [polypeptide binding]; other site 345219002831 active site 345219002832 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 345219002833 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 345219002834 homodimer interface [polypeptide binding]; other site 345219002835 active site 345219002836 FMN binding site [chemical binding]; other site 345219002837 substrate binding site [chemical binding]; other site 345219002838 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 345219002839 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 345219002840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219002841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219002842 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 345219002843 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 345219002844 Na binding site [ion binding]; other site 345219002845 putative substrate binding site [chemical binding]; other site 345219002846 allantoate amidohydrolase; Reviewed; Region: PRK09290 345219002847 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 345219002848 active site 345219002849 metal binding site [ion binding]; metal-binding site 345219002850 dimer interface [polypeptide binding]; other site 345219002851 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 345219002852 Hydroxyethylphosphoate dehydrogenase (HEPD) catalyzes the reduction of phosphonoacetaldehyde (PnAA) to hydroxyethylphosphoate (HEP); Region: HEPD; cd08182 345219002853 putative active site [active] 345219002854 metal binding site [ion binding]; metal-binding site 345219002855 hypothetical protein; Provisional; Region: PRK06062 345219002856 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219002857 inhibitor-cofactor binding pocket; inhibition site 345219002858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219002859 catalytic residue [active] 345219002860 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 345219002861 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 345219002862 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 345219002863 Cysteine-rich domain; Region: CCG; pfam02754 345219002864 Cysteine-rich domain; Region: CCG; pfam02754 345219002865 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 345219002866 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 345219002867 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 345219002868 Uncharacterized conserved protein [Function unknown]; Region: COG1556 345219002869 amino acid transporter; Region: 2A0306; TIGR00909 345219002870 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 345219002871 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 345219002872 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 345219002873 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 345219002874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002875 dimer interface [polypeptide binding]; other site 345219002876 conserved gate region; other site 345219002877 putative PBP binding loops; other site 345219002878 ABC-ATPase subunit interface; other site 345219002879 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 345219002880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219002881 dimer interface [polypeptide binding]; other site 345219002882 conserved gate region; other site 345219002883 putative PBP binding loops; other site 345219002884 ABC-ATPase subunit interface; other site 345219002885 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 345219002886 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 345219002887 Walker A/P-loop; other site 345219002888 ATP binding site [chemical binding]; other site 345219002889 Q-loop/lid; other site 345219002890 ABC transporter signature motif; other site 345219002891 Walker B; other site 345219002892 D-loop; other site 345219002893 H-loop/switch region; other site 345219002894 TOBE domain; Region: TOBE_2; pfam08402 345219002895 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 345219002896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219002897 non-specific DNA binding site [nucleotide binding]; other site 345219002898 salt bridge; other site 345219002899 sequence-specific DNA binding site [nucleotide binding]; other site 345219002900 Cupin domain; Region: Cupin_2; pfam07883 345219002901 lysine transporter; Provisional; Region: PRK10836 345219002902 Spore germination protein; Region: Spore_permease; cl17796 345219002903 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 345219002904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002905 putative substrate translocation pore; other site 345219002906 POT family; Region: PTR2; cl17359 345219002907 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 345219002908 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 345219002909 putative FMN binding site [chemical binding]; other site 345219002910 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219002911 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219002912 active site 345219002913 catalytic tetrad [active] 345219002914 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 345219002915 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 345219002916 tetramer interface [polypeptide binding]; other site 345219002917 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 345219002918 active site 345219002919 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 345219002920 phosphate binding site [ion binding]; other site 345219002921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219002922 D-galactonate transporter; Region: 2A0114; TIGR00893 345219002923 putative substrate translocation pore; other site 345219002924 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 345219002925 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 345219002926 substrate binding site [chemical binding]; other site 345219002927 ATP binding site [chemical binding]; other site 345219002928 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 345219002929 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219002930 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219002931 DNA binding site [nucleotide binding] 345219002932 domain linker motif; other site 345219002933 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 345219002934 putative dimerization interface [polypeptide binding]; other site 345219002935 putative ligand binding site [chemical binding]; other site 345219002936 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 345219002937 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 345219002938 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 345219002939 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 345219002940 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 345219002941 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219002942 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219002943 homodimer interface [polypeptide binding]; other site 345219002944 catalytic residue [active] 345219002945 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219002946 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219002947 Probable transposase; Region: OrfB_IS605; pfam01385 345219002948 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 345219002949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219002950 Walker A motif; other site 345219002951 ATP binding site [chemical binding]; other site 345219002952 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 345219002953 NADH(P)-binding; Region: NAD_binding_10; pfam13460 345219002954 NAD(P) binding site [chemical binding]; other site 345219002955 putative active site [active] 345219002956 mevalonate kinase; Region: mevalon_kin; TIGR00549 345219002957 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 345219002958 diphosphomevalonate decarboxylase; Region: PLN02407 345219002959 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 345219002960 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 345219002961 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 345219002962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 345219002963 active site 345219002964 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 345219002965 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 345219002966 glutaminase active site [active] 345219002967 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 345219002968 dimer interface [polypeptide binding]; other site 345219002969 active site 345219002970 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 345219002971 dimer interface [polypeptide binding]; other site 345219002972 active site 345219002973 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 345219002974 EamA-like transporter family; Region: EamA; pfam00892 345219002975 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 345219002976 EamA-like transporter family; Region: EamA; pfam00892 345219002977 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 345219002978 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 345219002979 metal binding site [ion binding]; metal-binding site 345219002980 active site 345219002981 I-site; other site 345219002982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 345219002983 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 345219002984 acyl-activating enzyme (AAE) consensus motif; other site 345219002985 putative active site [active] 345219002986 AMP binding site [chemical binding]; other site 345219002987 putative CoA binding site [chemical binding]; other site 345219002988 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 345219002989 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 345219002990 dimer interface [polypeptide binding]; other site 345219002991 active site 345219002992 metal binding site [ion binding]; metal-binding site 345219002993 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 345219002994 putative deacylase active site [active] 345219002995 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 345219002996 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 345219002997 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 345219002998 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 345219002999 putative active site [active] 345219003000 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 345219003001 putative active site [active] 345219003002 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 345219003003 diphthine synthase; Region: dph5; TIGR00522 345219003004 active site 345219003005 SAM binding site [chemical binding]; other site 345219003006 homodimer interface [polypeptide binding]; other site 345219003007 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 345219003008 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 345219003009 Active Sites [active] 345219003010 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 345219003011 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 345219003012 succinic semialdehyde dehydrogenase; Region: PLN02278 345219003013 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 345219003014 tetramerization interface [polypeptide binding]; other site 345219003015 NAD(P) binding site [chemical binding]; other site 345219003016 catalytic residues [active] 345219003017 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 345219003018 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 345219003019 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219003020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219003021 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 345219003022 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 345219003023 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 345219003024 Phosphotransferase enzyme family; Region: APH; pfam01636 345219003025 putative active site [active] 345219003026 putative substrate binding site [chemical binding]; other site 345219003027 ATP binding site [chemical binding]; other site 345219003028 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 345219003029 active site 345219003030 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219003031 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219003032 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 345219003033 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 345219003034 acyl-activating enzyme (AAE) consensus motif; other site 345219003035 putative AMP binding site [chemical binding]; other site 345219003036 putative active site [active] 345219003037 putative CoA binding site [chemical binding]; other site 345219003038 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 345219003039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219003040 NAD(P) binding site [chemical binding]; other site 345219003041 active site 345219003042 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219003043 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 345219003044 FAD binding site [chemical binding]; other site 345219003045 substrate binding site [chemical binding]; other site 345219003046 catalytic base [active] 345219003047 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 345219003048 hypothetical protein; Provisional; Region: PRK12378 345219003049 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 345219003050 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219003051 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 345219003052 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 345219003053 Walker A/P-loop; other site 345219003054 ATP binding site [chemical binding]; other site 345219003055 Q-loop/lid; other site 345219003056 ABC transporter signature motif; other site 345219003057 Walker B; other site 345219003058 D-loop; other site 345219003059 H-loop/switch region; other site 345219003060 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 345219003061 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 345219003062 intersubunit interface [polypeptide binding]; other site 345219003063 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 345219003064 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 345219003065 ABC-ATPase subunit interface; other site 345219003066 dimer interface [polypeptide binding]; other site 345219003067 putative PBP binding regions; other site 345219003068 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 345219003069 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 345219003070 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 345219003071 ABC-ATPase subunit interface; other site 345219003072 dimer interface [polypeptide binding]; other site 345219003073 putative PBP binding regions; other site 345219003074 hypothetical protein; Provisional; Region: PRK10621 345219003075 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 345219003076 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 345219003077 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 345219003078 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 345219003079 EamA-like transporter family; Region: EamA; pfam00892 345219003080 EamA-like transporter family; Region: EamA; pfam00892 345219003081 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 345219003082 CoenzymeA binding site [chemical binding]; other site 345219003083 subunit interaction site [polypeptide binding]; other site 345219003084 PHB binding site; other site 345219003085 Mu B transposition protein, C terminal; Region: Phage-MuB_C; pfam09077 345219003086 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219003087 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219003088 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 345219003089 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 345219003090 active site 345219003091 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 345219003092 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 345219003093 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 345219003094 dimer interface [polypeptide binding]; other site 345219003095 putative radical transfer pathway; other site 345219003096 diiron center [ion binding]; other site 345219003097 tyrosyl radical; other site 345219003098 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 345219003099 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 345219003100 Class I ribonucleotide reductase; Region: RNR_I; cd01679 345219003101 active site 345219003102 dimer interface [polypeptide binding]; other site 345219003103 catalytic residues [active] 345219003104 effector binding site; other site 345219003105 R2 peptide binding site; other site 345219003106 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 345219003107 metal-binding site [ion binding] 345219003108 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 345219003109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 345219003110 Soluble P-type ATPase [General function prediction only]; Region: COG4087 345219003111 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 345219003112 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 345219003113 ligand binding site [chemical binding]; other site 345219003114 flexible hinge region; other site 345219003115 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 345219003116 putative switch regulator; other site 345219003117 non-specific DNA interactions [nucleotide binding]; other site 345219003118 DNA binding site [nucleotide binding] 345219003119 sequence specific DNA binding site [nucleotide binding]; other site 345219003120 putative cAMP binding site [chemical binding]; other site 345219003121 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 345219003122 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 345219003123 GIY-YIG motif/motif A; other site 345219003124 active site 345219003125 catalytic site [active] 345219003126 putative DNA binding site [nucleotide binding]; other site 345219003127 metal binding site [ion binding]; metal-binding site 345219003128 UvrB/uvrC motif; Region: UVR; pfam02151 345219003129 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 345219003130 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 345219003131 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 345219003132 Transcriptional regulators [Transcription]; Region: GntR; COG1802 345219003133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219003134 DNA-binding site [nucleotide binding]; DNA binding site 345219003135 FCD domain; Region: FCD; pfam07729 345219003136 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 345219003137 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 345219003138 N- and C-terminal domain interface [polypeptide binding]; other site 345219003139 active site 345219003140 catalytic site [active] 345219003141 metal binding site [ion binding]; metal-binding site 345219003142 carbohydrate binding site [chemical binding]; other site 345219003143 ATP binding site [chemical binding]; other site 345219003144 GntP family permease; Region: GntP_permease; pfam02447 345219003145 fructuronate transporter; Provisional; Region: PRK10034; cl15264 345219003146 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 345219003147 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219003148 DNA-binding site [nucleotide binding]; DNA binding site 345219003149 UTRA domain; Region: UTRA; pfam07702 345219003150 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 345219003151 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 345219003152 Ca binding site [ion binding]; other site 345219003153 active site 345219003154 catalytic site [active] 345219003155 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 345219003156 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 345219003157 active site turn [active] 345219003158 phosphorylation site [posttranslational modification] 345219003159 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 345219003160 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 345219003161 HPr interaction site; other site 345219003162 glycerol kinase (GK) interaction site [polypeptide binding]; other site 345219003163 active site 345219003164 phosphorylation site [posttranslational modification] 345219003165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219003166 ABC-ATPase subunit interface; other site 345219003167 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 345219003168 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 345219003169 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 345219003170 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 345219003171 Walker A/P-loop; other site 345219003172 ATP binding site [chemical binding]; other site 345219003173 Q-loop/lid; other site 345219003174 ABC transporter signature motif; other site 345219003175 Walker B; other site 345219003176 D-loop; other site 345219003177 H-loop/switch region; other site 345219003178 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 345219003179 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 345219003180 dimerization interface [polypeptide binding]; other site 345219003181 ligand binding site [chemical binding]; other site 345219003182 NADP binding site [chemical binding]; other site 345219003183 catalytic site [active] 345219003184 DsrE/DsrF-like family; Region: DrsE; pfam02635 345219003185 putative acyltransferase; Provisional; Region: PRK05790 345219003186 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 345219003187 dimer interface [polypeptide binding]; other site 345219003188 active site 345219003189 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219003190 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 345219003191 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 345219003192 dimer interface [polypeptide binding]; other site 345219003193 active site 345219003194 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 345219003195 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 345219003196 putative active site [active] 345219003197 putative NTP binding site [chemical binding]; other site 345219003198 putative nucleic acid binding site [nucleotide binding]; other site 345219003199 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 345219003200 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 345219003201 homodimer interface [polypeptide binding]; other site 345219003202 catalytic residues [active] 345219003203 NAD binding site [chemical binding]; other site 345219003204 substrate binding pocket [chemical binding]; other site 345219003205 flexible flap; other site 345219003206 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219003207 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 345219003208 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 345219003209 Transposase [DNA replication, recombination, and repair]; Region: COG5421 345219003210 CAAX protease self-immunity; Region: Abi; pfam02517 345219003211 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 345219003212 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 345219003213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219003214 Coenzyme A binding pocket [chemical binding]; other site 345219003215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219003216 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219003217 putative substrate translocation pore; other site 345219003218 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 345219003219 nudix motif; other site 345219003220 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 345219003221 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219003222 Coenzyme A binding pocket [chemical binding]; other site 345219003223 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 345219003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219003225 Coenzyme A binding pocket [chemical binding]; other site 345219003226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219003227 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219003228 putative substrate translocation pore; other site 345219003229 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 345219003230 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 345219003231 Protein of unknown function (DUF3219); Region: DUF3219; pfam11514 345219003232 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219003233 dimerization interface [polypeptide binding]; other site 345219003234 putative DNA binding site [nucleotide binding]; other site 345219003235 putative Zn2+ binding site [ion binding]; other site 345219003236 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 345219003237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219003238 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219003239 putative substrate translocation pore; other site 345219003240 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219003241 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219003242 Isochorismatase family; Region: Isochorismatase; pfam00857 345219003243 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 345219003244 catalytic triad [active] 345219003245 conserved cis-peptide bond; other site 345219003246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219003247 putative substrate translocation pore; other site 345219003248 Cache domain; Region: Cache_2; cl07034 345219003249 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219003250 dimerization interface [polypeptide binding]; other site 345219003251 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219003252 dimer interface [polypeptide binding]; other site 345219003253 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219003254 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219003255 dimer interface [polypeptide binding]; other site 345219003256 putative CheW interface [polypeptide binding]; other site 345219003257 Predicted transcriptional regulators [Transcription]; Region: COG1695 345219003258 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 345219003259 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 345219003260 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 345219003261 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 345219003262 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 345219003263 heme-binding site [chemical binding]; other site 345219003264 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219003265 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219003266 dimer interface [polypeptide binding]; other site 345219003267 putative CheW interface [polypeptide binding]; other site 345219003268 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 345219003269 NAD-dependent deacetylase; Provisional; Region: PRK00481 345219003270 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 345219003271 NAD+ binding site [chemical binding]; other site 345219003272 substrate binding site [chemical binding]; other site 345219003273 Zn binding site [ion binding]; other site 345219003274 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 345219003275 Protein of unknown function (DUF1399); Region: DUF1399; pfam07173 345219003276 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219003278 putative substrate translocation pore; other site 345219003279 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 345219003280 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 345219003281 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 345219003282 glutaminase active site [active] 345219003283 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 345219003284 dimer interface [polypeptide binding]; other site 345219003285 active site 345219003286 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 345219003287 dimer interface [polypeptide binding]; other site 345219003288 active site 345219003289 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 345219003290 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 345219003291 active site 345219003292 substrate binding site [chemical binding]; other site 345219003293 metal binding site [ion binding]; metal-binding site 345219003294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 345219003295 YbbR-like protein; Region: YbbR; pfam07949 345219003296 YbbR-like protein; Region: YbbR; pfam07949 345219003297 Uncharacterized conserved protein [Function unknown]; Region: COG1624 345219003298 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 345219003299 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 345219003300 Putative zinc-finger; Region: zf-HC2; pfam13490 345219003301 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 345219003302 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 345219003303 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219003304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219003305 DNA binding residues [nucleotide binding] 345219003306 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 345219003307 Arginase family; Region: Arginase; cd09989 345219003308 agmatinase; Region: agmatinase; TIGR01230 345219003309 active site 345219003310 Mn binding site [ion binding]; other site 345219003311 oligomer interface [polypeptide binding]; other site 345219003312 short chain dehydrogenase; Provisional; Region: PRK06172 345219003313 classical (c) SDRs; Region: SDR_c; cd05233 345219003314 NAD(P) binding site [chemical binding]; other site 345219003315 active site 345219003316 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 345219003317 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219003318 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 345219003319 Walker A/P-loop; other site 345219003320 ATP binding site [chemical binding]; other site 345219003321 Q-loop/lid; other site 345219003322 ABC transporter signature motif; other site 345219003323 Walker B; other site 345219003324 D-loop; other site 345219003325 H-loop/switch region; other site 345219003326 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 345219003327 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219003328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219003329 Walker A/P-loop; other site 345219003330 ATP binding site [chemical binding]; other site 345219003331 Q-loop/lid; other site 345219003332 ABC transporter signature motif; other site 345219003333 Walker B; other site 345219003334 D-loop; other site 345219003335 H-loop/switch region; other site 345219003336 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 345219003337 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 345219003338 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 345219003339 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 345219003340 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 345219003341 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 345219003342 Choloylglycine hydrolase (CGH)_like. This family of choloylglycine hydrolase-like proteins includes conjugated bile acid hydrolase (CBAH), penicillin V acylase (PVA), acid ceramidase (AC), and N-acylethanolamine-hydrolyzing acid amidase (NAAA) which...; Region: Ntn_CGH_like; cd01935 345219003343 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 345219003344 active site 345219003345 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 345219003346 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 345219003347 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 345219003348 Walker A motif; other site 345219003349 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 345219003350 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 345219003351 active site 345219003352 metal binding site [ion binding]; metal-binding site 345219003353 Protein of unknown function (DUF2521); Region: DUF2521; pfam10730 345219003354 Amino acid transporters [Amino acid transport and metabolism]; Region: LysP; COG0833 345219003355 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 345219003356 AAA domain; Region: AAA_18; pfam13238 345219003357 ligand-binding site [chemical binding]; other site 345219003358 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 345219003359 ATP-sulfurylase; Region: ATPS; cd00517 345219003360 active site 345219003361 HXXH motif; other site 345219003362 flexible loop; other site 345219003363 Uncharacterized conserved protein [Function unknown]; Region: COG3379 345219003364 Uncharacterized conserved protein [Function unknown]; Region: COG3379 345219003365 hydroperoxidase II; Provisional; Region: katE; PRK11249 345219003366 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 345219003367 heme binding pocket [chemical binding]; other site 345219003368 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 345219003369 domain interactions; other site 345219003370 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 345219003371 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 345219003372 23S rRNA interface [nucleotide binding]; other site 345219003373 L3 interface [polypeptide binding]; other site 345219003374 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 345219003375 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 345219003376 dimerization interface 3.5A [polypeptide binding]; other site 345219003377 active site 345219003378 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 345219003379 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 345219003380 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 345219003381 Walker A/P-loop; other site 345219003382 ATP binding site [chemical binding]; other site 345219003383 Q-loop/lid; other site 345219003384 ABC transporter signature motif; other site 345219003385 Walker B; other site 345219003386 D-loop; other site 345219003387 H-loop/switch region; other site 345219003388 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 345219003389 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 345219003390 Walker A/P-loop; other site 345219003391 ATP binding site [chemical binding]; other site 345219003392 Q-loop/lid; other site 345219003393 ABC transporter signature motif; other site 345219003394 Walker B; other site 345219003395 D-loop; other site 345219003396 H-loop/switch region; other site 345219003397 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 345219003398 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 345219003399 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 345219003400 alphaNTD homodimer interface [polypeptide binding]; other site 345219003401 alphaNTD - beta interaction site [polypeptide binding]; other site 345219003402 alphaNTD - beta' interaction site [polypeptide binding]; other site 345219003403 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 345219003404 30S ribosomal protein S11; Validated; Region: PRK05309 345219003405 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 345219003406 30S ribosomal protein S13; Region: bact_S13; TIGR03631 345219003407 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 345219003408 rRNA binding site [nucleotide binding]; other site 345219003409 predicted 30S ribosome binding site; other site 345219003410 adenylate kinase; Reviewed; Region: adk; PRK00279 345219003411 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 345219003412 AMP-binding site [chemical binding]; other site 345219003413 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 345219003414 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 345219003415 SecY translocase; Region: SecY; pfam00344 345219003416 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 345219003417 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 345219003418 23S rRNA binding site [nucleotide binding]; other site 345219003419 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 345219003420 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 345219003421 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 345219003422 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 345219003423 23S rRNA interface [nucleotide binding]; other site 345219003424 5S rRNA interface [nucleotide binding]; other site 345219003425 L27 interface [polypeptide binding]; other site 345219003426 L5 interface [polypeptide binding]; other site 345219003427 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 345219003428 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 345219003429 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 345219003430 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 345219003431 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 345219003432 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 345219003433 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 345219003434 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 345219003435 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 345219003436 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 345219003437 RNA binding site [nucleotide binding]; other site 345219003438 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 345219003439 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 345219003440 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 345219003441 23S rRNA interface [nucleotide binding]; other site 345219003442 putative translocon interaction site; other site 345219003443 signal recognition particle (SRP54) interaction site; other site 345219003444 L23 interface [polypeptide binding]; other site 345219003445 trigger factor interaction site; other site 345219003446 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 345219003447 23S rRNA interface [nucleotide binding]; other site 345219003448 5S rRNA interface [nucleotide binding]; other site 345219003449 putative antibiotic binding site [chemical binding]; other site 345219003450 L25 interface [polypeptide binding]; other site 345219003451 L27 interface [polypeptide binding]; other site 345219003452 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 345219003453 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 345219003454 G-X-X-G motif; other site 345219003455 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 345219003456 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 345219003457 putative translocon binding site; other site 345219003458 protein-rRNA interface [nucleotide binding]; other site 345219003459 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 345219003460 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 345219003461 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 345219003462 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 345219003463 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 345219003464 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 345219003465 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 345219003466 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 345219003467 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219003468 elongation factor Tu; Reviewed; Region: PRK00049 345219003469 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 345219003470 G1 box; other site 345219003471 GEF interaction site [polypeptide binding]; other site 345219003472 GTP/Mg2+ binding site [chemical binding]; other site 345219003473 Switch I region; other site 345219003474 G2 box; other site 345219003475 G3 box; other site 345219003476 Switch II region; other site 345219003477 G4 box; other site 345219003478 G5 box; other site 345219003479 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 345219003480 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 345219003481 Antibiotic Binding Site [chemical binding]; other site 345219003482 elongation factor G; Reviewed; Region: PRK00007 345219003483 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 345219003484 G1 box; other site 345219003485 putative GEF interaction site [polypeptide binding]; other site 345219003486 GTP/Mg2+ binding site [chemical binding]; other site 345219003487 Switch I region; other site 345219003488 G2 box; other site 345219003489 G3 box; other site 345219003490 Switch II region; other site 345219003491 G4 box; other site 345219003492 G5 box; other site 345219003493 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 345219003494 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 345219003495 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 345219003496 30S ribosomal protein S7; Validated; Region: PRK05302 345219003497 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 345219003498 S17 interaction site [polypeptide binding]; other site 345219003499 S8 interaction site; other site 345219003500 16S rRNA interaction site [nucleotide binding]; other site 345219003501 streptomycin interaction site [chemical binding]; other site 345219003502 23S rRNA interaction site [nucleotide binding]; other site 345219003503 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 345219003504 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 345219003505 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 345219003506 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 345219003507 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 345219003508 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 345219003509 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 345219003510 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 345219003511 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 345219003512 G-loop; other site 345219003513 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 345219003514 DNA binding site [nucleotide binding] 345219003515 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 345219003516 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 345219003517 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 345219003518 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 345219003519 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 345219003520 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 345219003521 RPB1 interaction site [polypeptide binding]; other site 345219003522 RPB10 interaction site [polypeptide binding]; other site 345219003523 RPB11 interaction site [polypeptide binding]; other site 345219003524 RPB3 interaction site [polypeptide binding]; other site 345219003525 RPB12 interaction site [polypeptide binding]; other site 345219003526 Methyltransferase domain; Region: Methyltransf_31; pfam13847 345219003527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219003528 S-adenosylmethionine binding site [chemical binding]; other site 345219003529 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 345219003530 core dimer interface [polypeptide binding]; other site 345219003531 peripheral dimer interface [polypeptide binding]; other site 345219003532 L10 interface [polypeptide binding]; other site 345219003533 L11 interface [polypeptide binding]; other site 345219003534 putative EF-Tu interaction site [polypeptide binding]; other site 345219003535 putative EF-G interaction site [polypeptide binding]; other site 345219003536 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 345219003537 23S rRNA interface [nucleotide binding]; other site 345219003538 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 345219003539 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 345219003540 mRNA/rRNA interface [nucleotide binding]; other site 345219003541 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 345219003542 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 345219003543 23S rRNA interface [nucleotide binding]; other site 345219003544 L7/L12 interface [polypeptide binding]; other site 345219003545 putative thiostrepton binding site; other site 345219003546 L25 interface [polypeptide binding]; other site 345219003547 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 345219003548 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 345219003549 putative homodimer interface [polypeptide binding]; other site 345219003550 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 345219003551 heterodimer interface [polypeptide binding]; other site 345219003552 homodimer interface [polypeptide binding]; other site 345219003553 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 345219003554 RNA polymerase factor sigma-70; Validated; Region: PRK08295 345219003555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219003556 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 345219003557 YacP-like NYN domain; Region: NYN_YacP; cl01491 345219003558 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 345219003559 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 345219003560 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 345219003561 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 345219003562 active site 345219003563 metal binding site [ion binding]; metal-binding site 345219003564 dimerization interface [polypeptide binding]; other site 345219003565 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 345219003566 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 345219003567 active site 345219003568 HIGH motif; other site 345219003569 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 345219003570 KMSKS motif; other site 345219003571 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 345219003572 tRNA binding surface [nucleotide binding]; other site 345219003573 anticodon binding site; other site 345219003574 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 345219003575 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 345219003576 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 345219003577 trimer interface [polypeptide binding]; other site 345219003578 active site 345219003579 substrate binding site [chemical binding]; other site 345219003580 CoA binding site [chemical binding]; other site 345219003581 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 345219003582 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 345219003583 HIGH motif; other site 345219003584 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 345219003585 active site 345219003586 KMSKS motif; other site 345219003587 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 345219003588 homotrimer interaction site [polypeptide binding]; other site 345219003589 zinc binding site [ion binding]; other site 345219003590 CDP-binding sites; other site 345219003591 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 345219003592 substrate binding site; other site 345219003593 dimer interface; other site 345219003594 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 345219003595 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 345219003596 putative active site [active] 345219003597 DNA repair protein RadA; Provisional; Region: PRK11823 345219003598 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 345219003599 Walker A motif/ATP binding site; other site 345219003600 ATP binding site [chemical binding]; other site 345219003601 Walker B motif; other site 345219003602 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 345219003603 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 345219003604 Clp amino terminal domain; Region: Clp_N; pfam02861 345219003605 Clp amino terminal domain; Region: Clp_N; pfam02861 345219003606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219003607 Walker A motif; other site 345219003608 ATP binding site [chemical binding]; other site 345219003609 Walker B motif; other site 345219003610 arginine finger; other site 345219003611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219003612 Walker A motif; other site 345219003613 ATP binding site [chemical binding]; other site 345219003614 Walker B motif; other site 345219003615 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 345219003616 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 345219003617 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 345219003618 ADP binding site [chemical binding]; other site 345219003619 phosphagen binding site; other site 345219003620 substrate specificity loop; other site 345219003621 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 345219003622 UvrB/uvrC motif; Region: UVR; pfam02151 345219003623 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 345219003624 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 345219003625 SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441 345219003626 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 345219003627 recombination protein RecR; Reviewed; Region: recR; PRK00076 345219003628 RecR protein; Region: RecR; pfam02132 345219003629 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 345219003630 putative active site [active] 345219003631 putative metal-binding site [ion binding]; other site 345219003632 tetramer interface [polypeptide binding]; other site 345219003633 hypothetical protein; Validated; Region: PRK00153 345219003634 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 345219003635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219003636 Walker A motif; other site 345219003637 ATP binding site [chemical binding]; other site 345219003638 Walker B motif; other site 345219003639 arginine finger; other site 345219003640 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 345219003641 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 345219003642 nucleoside/Zn binding site; other site 345219003643 dimer interface [polypeptide binding]; other site 345219003644 catalytic motif [active] 345219003645 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 345219003646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219003647 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219003648 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 345219003649 active site 345219003650 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 345219003651 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 345219003652 Substrate-binding site [chemical binding]; other site 345219003653 Substrate specificity [chemical binding]; other site 345219003654 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 345219003655 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 345219003656 Substrate-binding site [chemical binding]; other site 345219003657 Substrate specificity [chemical binding]; other site 345219003658 seryl-tRNA synthetase; Provisional; Region: PRK05431 345219003659 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 345219003660 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 345219003661 dimer interface [polypeptide binding]; other site 345219003662 active site 345219003663 motif 1; other site 345219003664 motif 2; other site 345219003665 motif 3; other site 345219003666 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 345219003667 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 345219003668 predicted active site [active] 345219003669 catalytic triad [active] 345219003670 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 345219003671 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 345219003672 active site 345219003673 multimer interface [polypeptide binding]; other site 345219003674 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 345219003675 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 345219003676 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 345219003677 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 345219003678 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 345219003679 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 345219003680 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 345219003681 active site 345219003682 YaaC-like Protein; Region: YaaC; pfam14175 345219003683 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 345219003684 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 345219003685 dimer interface [polypeptide binding]; other site 345219003686 putative anticodon binding site; other site 345219003687 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 345219003688 motif 1; other site 345219003689 active site 345219003690 motif 2; other site 345219003691 motif 3; other site 345219003692 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 345219003693 catalytic center binding site [active] 345219003694 ATP binding site [chemical binding]; other site 345219003695 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 345219003696 homooctamer interface [polypeptide binding]; other site 345219003697 active site 345219003698 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 345219003699 dihydropteroate synthase; Region: DHPS; TIGR01496 345219003700 substrate binding pocket [chemical binding]; other site 345219003701 dimer interface [polypeptide binding]; other site 345219003702 inhibitor binding site; inhibition site 345219003703 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 345219003704 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 345219003705 dimer interface [polypeptide binding]; other site 345219003706 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219003707 catalytic residue [active] 345219003708 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 345219003709 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 345219003710 dimerization interface [polypeptide binding]; other site 345219003711 domain crossover interface; other site 345219003712 redox-dependent activation switch; other site 345219003713 pantothenate kinase; Reviewed; Region: PRK13318 345219003714 FtsH Extracellular; Region: FtsH_ext; pfam06480 345219003715 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 345219003716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219003717 Walker A motif; other site 345219003718 ATP binding site [chemical binding]; other site 345219003719 Walker B motif; other site 345219003720 arginine finger; other site 345219003721 Peptidase family M41; Region: Peptidase_M41; pfam01434 345219003722 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219003723 active site 345219003724 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 345219003725 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 345219003726 Ligand Binding Site [chemical binding]; other site 345219003727 TilS substrate binding domain; Region: TilS; pfam09179 345219003728 TilS substrate C-terminal domain; Region: TilS_C; smart00977 345219003729 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 345219003730 Catalytic domain of Protein Kinases; Region: PKc; cd00180 345219003731 active site 345219003732 ATP binding site [chemical binding]; other site 345219003733 substrate binding site [chemical binding]; other site 345219003734 activation loop (A-loop); other site 345219003735 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 345219003736 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 345219003737 metal ion-dependent adhesion site (MIDAS); other site 345219003738 stage II sporulation protein E; Region: spore_II_E; TIGR02865 345219003739 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 345219003740 hypothetical protein; Provisional; Region: PRK08582 345219003741 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 345219003742 RNA binding site [nucleotide binding]; other site 345219003743 Septum formation initiator; Region: DivIC; pfam04977 345219003744 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 345219003745 spore cortex biosynthesis protein YabQ; Region: spore_yabQ; TIGR02893 345219003746 sporulation protein YabP; Region: spore_yabP; TIGR02892 345219003747 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219003748 RNA binding surface [nucleotide binding]; other site 345219003749 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 345219003750 putative SAM binding site [chemical binding]; other site 345219003751 putative homodimer interface [polypeptide binding]; other site 345219003752 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 345219003753 homodimer interface [polypeptide binding]; other site 345219003754 metal binding site [ion binding]; metal-binding site 345219003755 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 345219003756 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 345219003757 stage V sporulation protein T; Region: spore_V_T; TIGR02851 345219003758 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 345219003759 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 345219003760 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 345219003761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219003762 ATP binding site [chemical binding]; other site 345219003763 putative Mg++ binding site [ion binding]; other site 345219003764 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219003765 nucleotide binding region [chemical binding]; other site 345219003766 ATP-binding site [chemical binding]; other site 345219003767 TRCF domain; Region: TRCF; pfam03461 345219003768 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 345219003769 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 345219003770 putative active site [active] 345219003771 catalytic residue [active] 345219003772 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 345219003773 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 345219003774 5S rRNA interface [nucleotide binding]; other site 345219003775 CTC domain interface [polypeptide binding]; other site 345219003776 L16 interface [polypeptide binding]; other site 345219003777 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 345219003778 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 345219003779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219003780 active site 345219003781 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 345219003782 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 345219003783 Substrate binding site; other site 345219003784 Mg++ binding site; other site 345219003785 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 345219003786 active site 345219003787 substrate binding site [chemical binding]; other site 345219003788 CoA binding site [chemical binding]; other site 345219003789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219003790 ABC transporter signature motif; other site 345219003791 Walker B; other site 345219003792 D-loop; other site 345219003793 H-loop/switch region; other site 345219003794 regulatory protein SpoVG; Reviewed; Region: PRK13259 345219003795 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 345219003796 homotrimer interaction site [polypeptide binding]; other site 345219003797 putative active site [active] 345219003798 pur operon repressor; Provisional; Region: PRK09213 345219003799 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 345219003800 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219003801 active site 345219003802 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 345219003803 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 345219003804 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 345219003805 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 345219003806 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 345219003807 YabG peptidase U57; Region: Peptidase_U57; pfam05582 345219003808 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 345219003809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219003810 S-adenosylmethionine binding site [chemical binding]; other site 345219003811 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 345219003812 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 345219003813 putative active site [active] 345219003814 putative metal binding site [ion binding]; other site 345219003815 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 345219003816 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 345219003817 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 345219003818 active site 345219003819 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 345219003820 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 345219003821 active site 345219003822 HIGH motif; other site 345219003823 KMSKS motif; other site 345219003824 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 345219003825 tRNA binding surface [nucleotide binding]; other site 345219003826 anticodon binding site; other site 345219003827 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 345219003828 dimer interface [polypeptide binding]; other site 345219003829 putative tRNA-binding site [nucleotide binding]; other site 345219003830 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 345219003831 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 345219003832 Predicted methyltransferases [General function prediction only]; Region: COG0313 345219003833 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 345219003834 putative SAM binding site [chemical binding]; other site 345219003835 putative homodimer interface [polypeptide binding]; other site 345219003836 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 345219003837 GIY-YIG motif/motif A; other site 345219003838 putative active site [active] 345219003839 putative metal binding site [ion binding]; other site 345219003840 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 345219003841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219003842 S-adenosylmethionine binding site [chemical binding]; other site 345219003843 Protein of unknown function (DUF972); Region: DUF972; pfam06156 345219003844 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 345219003845 DNA polymerase III subunit delta'; Validated; Region: PRK08058 345219003846 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219003847 Walker A motif; other site 345219003848 ATP binding site [chemical binding]; other site 345219003849 Walker B motif; other site 345219003850 arginine finger; other site 345219003851 Protein of unknown function (DUF327); Region: DUF327; pfam03885 345219003852 Protein of unknown function (DUF970); Region: DUF970; pfam06153 345219003853 thymidylate kinase; Validated; Region: tmk; PRK00698 345219003854 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 345219003855 TMP-binding site; other site 345219003856 ATP-binding site [chemical binding]; other site 345219003857 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 345219003858 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 345219003859 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 345219003860 catalytic residue [active] 345219003861 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 345219003862 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 345219003863 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 345219003864 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 345219003865 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219003866 Zn2+ binding site [ion binding]; other site 345219003867 Mg2+ binding site [ion binding]; other site 345219003868 DNA gyrase subunit A; Validated; Region: PRK05560 345219003869 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 345219003870 CAP-like domain; other site 345219003871 active site 345219003872 primary dimer interface [polypeptide binding]; other site 345219003873 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219003874 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219003875 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219003876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219003877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219003878 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219003879 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 345219003880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219003881 Mg2+ binding site [ion binding]; other site 345219003882 G-X-G motif; other site 345219003883 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 345219003884 anchoring element; other site 345219003885 dimer interface [polypeptide binding]; other site 345219003886 ATP binding site [chemical binding]; other site 345219003887 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 345219003888 active site 345219003889 putative metal-binding site [ion binding]; other site 345219003890 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 345219003891 recombination protein F; Reviewed; Region: recF; PRK00064 345219003892 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 345219003893 Walker A/P-loop; other site 345219003894 ATP binding site [chemical binding]; other site 345219003895 Q-loop/lid; other site 345219003896 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219003897 ABC transporter signature motif; other site 345219003898 Walker B; other site 345219003899 D-loop; other site 345219003900 H-loop/switch region; other site 345219003901 S4 domain; Region: S4_2; pfam13275 345219003902 DNA polymerase III subunit beta; Validated; Region: PRK05643 345219003903 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 345219003904 putative DNA binding surface [nucleotide binding]; other site 345219003905 dimer interface [polypeptide binding]; other site 345219003906 beta-clamp/clamp loader binding surface; other site 345219003907 beta-clamp/translesion DNA polymerase binding surface; other site 345219003908 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 345219003909 DnaA N-terminal domain; Region: DnaA_N; pfam11638 345219003910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219003911 Walker A motif; other site 345219003912 ATP binding site [chemical binding]; other site 345219003913 Walker B motif; other site 345219003914 arginine finger; other site 345219003915 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 345219003916 DnaA box-binding interface [nucleotide binding]; other site 345219003917 ribonuclease P; Reviewed; Region: rnpA; PRK00499 345219003918 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 345219003919 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 345219003920 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 345219003921 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 345219003922 G-X-X-G motif; other site 345219003923 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 345219003924 RxxxH motif; other site 345219003925 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 345219003926 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 345219003927 trmE is a tRNA modification GTPase; Region: trmE; cd04164 345219003928 G1 box; other site 345219003929 GTP/Mg2+ binding site [chemical binding]; other site 345219003930 Switch I region; other site 345219003931 G2 box; other site 345219003932 Switch II region; other site 345219003933 G3 box; other site 345219003934 G4 box; other site 345219003935 G5 box; other site 345219003936 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 345219003937 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 345219003938 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 345219003939 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 345219003940 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 345219003941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219003942 S-adenosylmethionine binding site [chemical binding]; other site 345219003943 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 345219003944 ParB-like nuclease domain; Region: ParBc; pfam02195 345219003945 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 345219003946 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 345219003947 P-loop; other site 345219003948 Magnesium ion binding site [ion binding]; other site 345219003949 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 345219003950 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 345219003951 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 345219003952 ParB-like nuclease domain; Region: ParB; smart00470 345219003953 KorB domain; Region: KorB; pfam08535 345219003954 Protein of unknown function (DUF554); Region: DUF554; pfam04474 345219003955 putative sporulation protein YyaC; Region: spore_YyaC; TIGR02841 345219003956 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 345219003957 Mechanosensitive ion channel; Region: MS_channel; pfam00924 345219003958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 345219003959 GTP-binding protein YchF; Reviewed; Region: PRK09601 345219003960 YchF GTPase; Region: YchF; cd01900 345219003961 G1 box; other site 345219003962 GTP/Mg2+ binding site [chemical binding]; other site 345219003963 Switch I region; other site 345219003964 G2 box; other site 345219003965 Switch II region; other site 345219003966 G3 box; other site 345219003967 G4 box; other site 345219003968 G5 box; other site 345219003969 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 345219003970 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 345219003971 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 345219003972 catalytic motif [active] 345219003973 Zn binding site [ion binding]; other site 345219003974 RibD C-terminal domain; Region: RibD_C; cl17279 345219003975 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 345219003976 Lumazine binding domain; Region: Lum_binding; pfam00677 345219003977 Lumazine binding domain; Region: Lum_binding; pfam00677 345219003978 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 345219003979 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 345219003980 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 345219003981 dimerization interface [polypeptide binding]; other site 345219003982 active site 345219003983 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 345219003984 homopentamer interface [polypeptide binding]; other site 345219003985 active site 345219003986 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 345219003987 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 345219003988 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 345219003989 dimer interface [polypeptide binding]; other site 345219003990 ssDNA binding site [nucleotide binding]; other site 345219003991 tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219003992 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 345219003993 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 345219003994 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 345219003995 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 345219003996 DHH family; Region: DHH; pfam01368 345219003997 DHHA1 domain; Region: DHHA1; pfam02272 345219003998 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 345219003999 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 345219004000 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 345219004001 replicative DNA helicase; Provisional; Region: PRK05748 345219004002 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 345219004003 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 345219004004 Walker A motif; other site 345219004005 ATP binding site [chemical binding]; other site 345219004006 Walker B motif; other site 345219004007 DNA binding loops [nucleotide binding] 345219004008 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 345219004009 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 345219004010 GDP-binding site [chemical binding]; other site 345219004011 ACT binding site; other site 345219004012 IMP binding site; other site 345219004013 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219004014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219004015 active site 345219004016 phosphorylation site [posttranslational modification] 345219004017 intermolecular recognition site; other site 345219004018 dimerization interface [polypeptide binding]; other site 345219004019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219004020 DNA binding site [nucleotide binding] 345219004021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 345219004022 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219004023 dimerization interface [polypeptide binding]; other site 345219004024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219004025 putative active site [active] 345219004026 heme pocket [chemical binding]; other site 345219004027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219004028 dimer interface [polypeptide binding]; other site 345219004029 phosphorylation site [posttranslational modification] 345219004030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219004031 ATP binding site [chemical binding]; other site 345219004032 Mg2+ binding site [ion binding]; other site 345219004033 G-X-G motif; other site 345219004034 YycH protein; Region: YycH; pfam07435 345219004035 YycH protein; Region: YycI; pfam09648 345219004036 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 345219004037 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 345219004038 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 345219004039 protein binding site [polypeptide binding]; other site 345219004040 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 345219004041 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219004042 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 345219004043 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 345219004044 Predicted transcriptional regulators [Transcription]; Region: COG1695 345219004045 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 345219004046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 345219004047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219004048 active site 345219004049 phosphorylation site [posttranslational modification] 345219004050 intermolecular recognition site; other site 345219004051 dimerization interface [polypeptide binding]; other site 345219004052 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 345219004053 DNA binding residues [nucleotide binding] 345219004054 dimerization interface [polypeptide binding]; other site 345219004055 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 345219004056 Histidine kinase; Region: HisKA_3; pfam07730 345219004057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219004058 ATP binding site [chemical binding]; other site 345219004059 Mg2+ binding site [ion binding]; other site 345219004060 G-X-G motif; other site 345219004061 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 345219004062 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 345219004063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219004064 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219004065 Walker A/P-loop; other site 345219004066 ATP binding site [chemical binding]; other site 345219004067 Q-loop/lid; other site 345219004068 ABC transporter signature motif; other site 345219004069 Walker B; other site 345219004070 D-loop; other site 345219004071 H-loop/switch region; other site 345219004072 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 345219004073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219004074 putative substrate translocation pore; other site 345219004075 malate:quinone oxidoreductase; Validated; Region: PRK05257 345219004076 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 345219004077 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219004078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219004079 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219004080 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 345219004081 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219004082 dimer interface [polypeptide binding]; other site 345219004083 conserved gate region; other site 345219004084 putative PBP binding loops; other site 345219004085 ABC-ATPase subunit interface; other site 345219004086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219004087 dimer interface [polypeptide binding]; other site 345219004088 conserved gate region; other site 345219004089 ABC-ATPase subunit interface; other site 345219004090 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 345219004091 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 345219004092 Walker A/P-loop; other site 345219004093 ATP binding site [chemical binding]; other site 345219004094 Q-loop/lid; other site 345219004095 ABC transporter signature motif; other site 345219004096 Walker B; other site 345219004097 D-loop; other site 345219004098 H-loop/switch region; other site 345219004099 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 345219004100 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219004101 substrate binding pocket [chemical binding]; other site 345219004102 membrane-bound complex binding site; other site 345219004103 hinge residues; other site 345219004104 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 345219004105 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 345219004106 active site 345219004107 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 345219004108 dimer interface [polypeptide binding]; other site 345219004109 substrate binding site [chemical binding]; other site 345219004110 catalytic residue [active] 345219004111 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 345219004112 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 345219004113 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 345219004114 dimer interface [polypeptide binding]; other site 345219004115 active site 345219004116 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 345219004117 catalytic residues [active] 345219004118 substrate binding site [chemical binding]; other site 345219004119 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 345219004120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219004121 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 345219004122 putative phosphoketolase; Provisional; Region: PRK05261 345219004123 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 345219004124 TPP-binding site; other site 345219004125 XFP C-terminal domain; Region: XFP_C; pfam09363 345219004126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219004127 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 345219004128 DNA-binding site [nucleotide binding]; DNA binding site 345219004129 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 345219004130 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 345219004131 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 345219004132 I-site; other site 345219004133 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 345219004134 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 345219004135 active site 345219004136 Na/Ca binding site [ion binding]; other site 345219004137 catalytic site [active] 345219004138 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 345219004139 MMPL family; Region: MMPL; pfam03176 345219004140 MMPL family; Region: MMPL; pfam03176 345219004141 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 345219004142 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 345219004143 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 345219004144 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219004145 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219004146 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219004147 Walker A/P-loop; other site 345219004148 ATP binding site [chemical binding]; other site 345219004149 Q-loop/lid; other site 345219004150 ABC transporter signature motif; other site 345219004151 Walker B; other site 345219004152 D-loop; other site 345219004153 H-loop/switch region; other site 345219004154 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 345219004155 intersubunit interface [polypeptide binding]; other site 345219004156 active site 345219004157 catalytic residue [active] 345219004158 pyruvate dehydrogenase; Provisional; Region: PRK09124 345219004159 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 345219004160 PYR/PP interface [polypeptide binding]; other site 345219004161 tetramer interface [polypeptide binding]; other site 345219004162 dimer interface [polypeptide binding]; other site 345219004163 TPP binding site [chemical binding]; other site 345219004164 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 345219004165 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 345219004166 TPP-binding site [chemical binding]; other site 345219004167 uracil transporter; Provisional; Region: PRK10720 345219004168 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 345219004169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219004170 putative substrate translocation pore; other site 345219004171 peptidase T; Region: peptidase-T; TIGR01882 345219004172 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 345219004173 metal binding site [ion binding]; metal-binding site 345219004174 dimer interface [polypeptide binding]; other site 345219004175 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 345219004176 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 345219004177 Ligand binding site; other site 345219004178 metal-binding site 345219004179 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 345219004180 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 345219004181 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 345219004182 Mg binding site [ion binding]; other site 345219004183 nucleotide binding site [chemical binding]; other site 345219004184 putative protofilament interface [polypeptide binding]; other site 345219004185 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 345219004186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219004187 Walker A/P-loop; other site 345219004188 ATP binding site [chemical binding]; other site 345219004189 Q-loop/lid; other site 345219004190 ABC transporter signature motif; other site 345219004191 Walker B; other site 345219004192 D-loop; other site 345219004193 H-loop/switch region; other site 345219004194 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 345219004195 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 345219004196 Walker A/P-loop; other site 345219004197 ATP binding site [chemical binding]; other site 345219004198 Q-loop/lid; other site 345219004199 ABC transporter signature motif; other site 345219004200 Walker B; other site 345219004201 D-loop; other site 345219004202 H-loop/switch region; other site 345219004203 NIL domain; Region: NIL; pfam09383 345219004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219004205 ABC-ATPase subunit interface; other site 345219004206 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 345219004207 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 345219004208 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 345219004209 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 345219004210 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 345219004211 Histidine kinase; Region: His_kinase; pfam06580 345219004212 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219004213 ATP binding site [chemical binding]; other site 345219004214 Mg2+ binding site [ion binding]; other site 345219004215 G-X-G motif; other site 345219004216 two-component response regulator; Provisional; Region: PRK14084 345219004217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219004218 active site 345219004219 phosphorylation site [posttranslational modification] 345219004220 intermolecular recognition site; other site 345219004221 dimerization interface [polypeptide binding]; other site 345219004222 LytTr DNA-binding domain; Region: LytTR; pfam04397 345219004223 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 345219004224 Carbon starvation protein CstA; Region: CstA; pfam02554 345219004225 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 345219004226 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 345219004227 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 345219004228 homodimer interface [polypeptide binding]; other site 345219004229 substrate-cofactor binding pocket; other site 345219004230 catalytic residue [active] 345219004231 Uncharacterized conserved protein [Function unknown]; Region: COG2966 345219004232 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 345219004233 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 345219004234 DDE superfamily endonuclease; Region: DDE_5; cl17874 345219004235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219004236 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 345219004237 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 345219004238 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 345219004239 active site 345219004240 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 345219004241 dimer interface [polypeptide binding]; other site 345219004242 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 345219004243 Ligand Binding Site [chemical binding]; other site 345219004244 Molecular Tunnel; other site 345219004245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 345219004246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 345219004247 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 345219004248 putative dimerization interface [polypeptide binding]; other site 345219004249 holin-like protein; Validated; Region: PRK01658 345219004250 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 345219004251 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 345219004252 putative deacylase active site [active] 345219004253 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 345219004254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219004255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219004256 active site 345219004257 phosphorylation site [posttranslational modification] 345219004258 intermolecular recognition site; other site 345219004259 dimerization interface [polypeptide binding]; other site 345219004260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219004261 DNA binding site [nucleotide binding] 345219004262 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219004263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219004264 dimer interface [polypeptide binding]; other site 345219004265 phosphorylation site [posttranslational modification] 345219004266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219004267 ATP binding site [chemical binding]; other site 345219004268 Mg2+ binding site [ion binding]; other site 345219004269 G-X-G motif; other site 345219004270 Pilus assembly protein, PilO; Region: PilO; cl01234 345219004271 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 345219004272 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 345219004273 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 345219004274 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 345219004275 putative active site [active] 345219004276 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 345219004277 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 345219004278 dimer interface [polypeptide binding]; other site 345219004279 active site 345219004280 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 345219004281 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219004282 ATP binding site [chemical binding]; other site 345219004283 putative Mg++ binding site [ion binding]; other site 345219004284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219004285 nucleotide binding region [chemical binding]; other site 345219004286 ATP-binding site [chemical binding]; other site 345219004287 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 345219004288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 345219004289 HRDC domain; Region: HRDC; pfam00570 345219004290 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 345219004291 DNA binding residues [nucleotide binding] 345219004292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219004293 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 345219004294 active site 345219004295 motif I; other site 345219004296 motif II; other site 345219004297 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 345219004298 bacillithiol biosynthesis deacetylase BshB2; Region: thiol_BshB2; TIGR04000 345219004299 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 345219004300 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 345219004301 dimer interface [polypeptide binding]; other site 345219004302 substrate binding site [chemical binding]; other site 345219004303 ATP binding site [chemical binding]; other site 345219004304 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219004305 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 345219004306 Walker A/P-loop; other site 345219004307 ATP binding site [chemical binding]; other site 345219004308 Q-loop/lid; other site 345219004309 ABC transporter signature motif; other site 345219004310 Walker B; other site 345219004311 D-loop; other site 345219004312 H-loop/switch region; other site 345219004313 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 345219004314 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 345219004315 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219004316 Walker A/P-loop; other site 345219004317 ATP binding site [chemical binding]; other site 345219004318 Q-loop/lid; other site 345219004319 ABC transporter signature motif; other site 345219004320 Walker B; other site 345219004321 D-loop; other site 345219004322 H-loop/switch region; other site 345219004323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219004324 non-specific DNA binding site [nucleotide binding]; other site 345219004325 salt bridge; other site 345219004326 sequence-specific DNA binding site [nucleotide binding]; other site 345219004327 Heat induced stress protein YflT; Region: YflT; pfam11181 345219004328 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 345219004329 ligand binding site [chemical binding]; other site 345219004330 active site 345219004331 UGI interface [polypeptide binding]; other site 345219004332 catalytic site [active] 345219004333 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 345219004334 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 345219004335 putative heme peroxidase; Provisional; Region: PRK12276 345219004336 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 345219004337 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 345219004338 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 345219004339 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 345219004340 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219004341 Zn2+ binding site [ion binding]; other site 345219004342 Mg2+ binding site [ion binding]; other site 345219004343 Uncharacterized conserved protein [Function unknown]; Region: COG3465 345219004344 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cd00491 345219004345 active site 1 [active] 345219004346 dimer interface [polypeptide binding]; other site 345219004347 hexamer interface [polypeptide binding]; other site 345219004348 active site 2 [active] 345219004349 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 345219004350 Peptidase family M50; Region: Peptidase_M50; pfam02163 345219004351 active site 345219004352 putative substrate binding region [chemical binding]; other site 345219004353 YwhD family; Region: YwhD; pfam08741 345219004354 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 345219004355 Transglycosylase; Region: Transgly; pfam00912 345219004356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 345219004357 agmatinase; Region: agmatinase; TIGR01230 345219004358 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 345219004359 putative active site [active] 345219004360 Mn binding site [ion binding]; other site 345219004361 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 345219004362 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 345219004363 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 345219004364 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 345219004365 active site 345219004366 HIGH motif; other site 345219004367 KMSK motif region; other site 345219004368 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 345219004369 tRNA binding surface [nucleotide binding]; other site 345219004370 anticodon binding site; other site 345219004371 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 345219004372 putative active site [active] 345219004373 catalytic site [active] 345219004374 PLD-like domain; Region: PLDc_2; pfam13091 345219004375 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 345219004376 putative active site [active] 345219004377 catalytic site [active] 345219004378 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 345219004379 Cysteine-rich domain; Region: CCG; pfam02754 345219004380 Cysteine-rich domain; Region: CCG; pfam02754 345219004381 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 345219004382 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 345219004383 dimer interface [polypeptide binding]; other site 345219004384 active site 345219004385 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219004386 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 345219004387 FAD binding site [chemical binding]; other site 345219004388 homotetramer interface [polypeptide binding]; other site 345219004389 substrate binding pocket [chemical binding]; other site 345219004390 catalytic base [active] 345219004391 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219004392 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 345219004393 FAD binding site [chemical binding]; other site 345219004394 homotetramer interface [polypeptide binding]; other site 345219004395 substrate binding pocket [chemical binding]; other site 345219004396 catalytic base [active] 345219004397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219004398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219004399 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 345219004400 B12 binding site [chemical binding]; other site 345219004401 cobalt ligand [ion binding]; other site 345219004402 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 345219004403 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 345219004404 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 345219004405 FtsX-like permease family; Region: FtsX; pfam02687 345219004406 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 345219004407 FtsX-like permease family; Region: FtsX; pfam02687 345219004408 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 345219004409 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 345219004410 Walker A/P-loop; other site 345219004411 ATP binding site [chemical binding]; other site 345219004412 Q-loop/lid; other site 345219004413 ABC transporter signature motif; other site 345219004414 Walker B; other site 345219004415 D-loop; other site 345219004416 H-loop/switch region; other site 345219004417 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 345219004418 CTP synthetase; Validated; Region: pyrG; PRK05380 345219004419 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 345219004420 Catalytic site [active] 345219004421 active site 345219004422 UTP binding site [chemical binding]; other site 345219004423 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 345219004424 active site 345219004425 putative oxyanion hole; other site 345219004426 catalytic triad [active] 345219004427 Predicted transcriptional regulators [Transcription]; Region: COG1725 345219004428 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219004429 DNA-binding site [nucleotide binding]; DNA binding site 345219004430 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 345219004431 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219004432 Walker A/P-loop; other site 345219004433 ATP binding site [chemical binding]; other site 345219004434 Q-loop/lid; other site 345219004435 ABC transporter signature motif; other site 345219004436 Walker B; other site 345219004437 D-loop; other site 345219004438 H-loop/switch region; other site 345219004439 Response regulator receiver domain; Region: Response_reg; pfam00072 345219004440 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219004441 active site 345219004442 phosphorylation site [posttranslational modification] 345219004443 intermolecular recognition site; other site 345219004444 dimerization interface [polypeptide binding]; other site 345219004445 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 345219004446 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 345219004447 intersubunit interface [polypeptide binding]; other site 345219004448 active site 345219004449 zinc binding site [ion binding]; other site 345219004450 Na+ binding site [ion binding]; other site 345219004451 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 345219004452 active site 345219004453 intersubunit interactions; other site 345219004454 catalytic residue [active] 345219004455 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 345219004456 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 345219004457 hinge; other site 345219004458 active site 345219004459 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 345219004460 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 345219004461 putative active site [active] 345219004462 transcription termination factor Rho; Provisional; Region: rho; PRK09376 345219004463 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 345219004464 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 345219004465 RNA binding site [nucleotide binding]; other site 345219004466 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 345219004467 multimer interface [polypeptide binding]; other site 345219004468 Walker A motif; other site 345219004469 ATP binding site [chemical binding]; other site 345219004470 Walker B motif; other site 345219004471 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 345219004472 thymidine kinase; Provisional; Region: PRK04296 345219004473 peptide chain release factor 1; Validated; Region: prfA; PRK00591 345219004474 This domain is found in peptide chain release factors; Region: PCRF; smart00937 345219004475 RF-1 domain; Region: RF-1; pfam00472 345219004476 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 345219004477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219004478 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 345219004479 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 345219004480 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 345219004481 Predicted membrane protein [Function unknown]; Region: COG1971 345219004482 Domain of unknown function DUF; Region: DUF204; pfam02659 345219004483 Domain of unknown function DUF; Region: DUF204; pfam02659 345219004484 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 345219004485 Low molecular weight phosphatase family; Region: LMWPc; cd00115 345219004486 active site 345219004487 HAMP domain; Region: HAMP; pfam00672 345219004488 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219004489 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219004490 dimer interface [polypeptide binding]; other site 345219004491 putative CheW interface [polypeptide binding]; other site 345219004492 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 345219004493 hypothetical protein; Provisional; Region: PRK13690 345219004494 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 345219004495 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 345219004496 dimer interface [polypeptide binding]; other site 345219004497 active site 345219004498 glycine-pyridoxal phosphate binding site [chemical binding]; other site 345219004499 folate binding site [chemical binding]; other site 345219004500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219004501 active site 345219004502 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 345219004503 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 345219004504 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 345219004505 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 345219004506 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 345219004507 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 345219004508 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 345219004509 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 345219004510 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 345219004511 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 345219004512 beta subunit interaction interface [polypeptide binding]; other site 345219004513 Walker A motif; other site 345219004514 ATP binding site [chemical binding]; other site 345219004515 Walker B motif; other site 345219004516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 345219004517 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 345219004518 core domain interface [polypeptide binding]; other site 345219004519 delta subunit interface [polypeptide binding]; other site 345219004520 epsilon subunit interface [polypeptide binding]; other site 345219004521 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 345219004522 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 345219004523 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 345219004524 alpha subunit interaction interface [polypeptide binding]; other site 345219004525 Walker A motif; other site 345219004526 ATP binding site [chemical binding]; other site 345219004527 Walker B motif; other site 345219004528 inhibitor binding site; inhibition site 345219004529 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 345219004530 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 345219004531 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 345219004532 gamma subunit interface [polypeptide binding]; other site 345219004533 epsilon subunit interface [polypeptide binding]; other site 345219004534 LBP interface [polypeptide binding]; other site 345219004535 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 345219004536 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 345219004537 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 345219004538 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 345219004539 hinge; other site 345219004540 active site 345219004541 Stage II sporulation protein; Region: SpoIID; pfam08486 345219004542 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 345219004543 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 345219004544 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 345219004545 E3 interaction surface; other site 345219004546 lipoyl attachment site [posttranslational modification]; other site 345219004547 Stage III sporulation protein D; Region: SpoIIID; pfam12116 345219004548 rod shape-determining protein Mbl; Provisional; Region: PRK13928 345219004549 MreB and similar proteins; Region: MreB_like; cd10225 345219004550 nucleotide binding site [chemical binding]; other site 345219004551 Mg binding site [ion binding]; other site 345219004552 putative protofilament interaction site [polypeptide binding]; other site 345219004553 RodZ interaction site [polypeptide binding]; other site 345219004554 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 345219004555 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 345219004556 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 345219004557 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 345219004558 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 345219004559 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 345219004560 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 345219004561 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 345219004562 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 345219004563 dimer interface [polypeptide binding]; other site 345219004564 ssDNA binding site [nucleotide binding]; other site 345219004565 tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219004566 YwpF-like protein; Region: YwpF; pfam14183 345219004567 SNF2 Helicase protein; Region: DUF3670; pfam12419 345219004568 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 345219004569 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219004570 ATP binding site [chemical binding]; other site 345219004571 putative Mg++ binding site [ion binding]; other site 345219004572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219004573 nucleotide binding region [chemical binding]; other site 345219004574 ATP-binding site [chemical binding]; other site 345219004575 Uncharacterized conserved protein [Function unknown]; Region: COG4715 345219004576 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219004577 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 345219004578 Domain of unknown function DUF21; Region: DUF21; pfam01595 345219004579 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 345219004580 Transporter associated domain; Region: CorC_HlyC; smart01091 345219004581 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg4; cd04779 345219004582 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 345219004583 DNA binding residues [nucleotide binding] 345219004584 putative dimer interface [polypeptide binding]; other site 345219004585 Domain of unknown function DUF21; Region: DUF21; pfam01595 345219004586 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 345219004587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 345219004588 Transporter associated domain; Region: CorC_HlyC; smart01091 345219004589 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 345219004590 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 345219004591 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 345219004592 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 345219004593 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 345219004594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 345219004595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 345219004596 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 345219004597 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 345219004598 Ca binding site [ion binding]; other site 345219004599 active site 345219004600 catalytic site [active] 345219004601 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 345219004602 maltose phosphorylase; Provisional; Region: PRK13807 345219004603 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 345219004604 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 345219004605 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 345219004606 Predicted integral membrane protein [Function unknown]; Region: COG5521 345219004607 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 345219004608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219004609 dimer interface [polypeptide binding]; other site 345219004610 conserved gate region; other site 345219004611 putative PBP binding loops; other site 345219004612 ABC-ATPase subunit interface; other site 345219004613 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 345219004614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219004615 dimer interface [polypeptide binding]; other site 345219004616 conserved gate region; other site 345219004617 putative PBP binding loops; other site 345219004618 ABC-ATPase subunit interface; other site 345219004619 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 345219004620 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 345219004621 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 345219004622 homodimer interface [polypeptide binding]; other site 345219004623 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 345219004624 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 345219004625 active site 345219004626 homodimer interface [polypeptide binding]; other site 345219004627 catalytic site [active] 345219004628 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 345219004629 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 345219004630 Ca binding site [ion binding]; other site 345219004631 active site 345219004632 catalytic site [active] 345219004633 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219004634 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219004635 DNA binding site [nucleotide binding] 345219004636 domain linker motif; other site 345219004637 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 345219004638 ligand binding site [chemical binding]; other site 345219004639 dimerization interface [polypeptide binding]; other site 345219004640 beta-phosphoglucomutase; Region: bPGM; TIGR01990 345219004641 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 345219004642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219004643 motif II; other site 345219004644 LysE type translocator; Region: LysE; pfam01810 345219004645 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 345219004646 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 345219004647 ATP binding site [chemical binding]; other site 345219004648 Mg++ binding site [ion binding]; other site 345219004649 motif III; other site 345219004650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219004651 nucleotide binding region [chemical binding]; other site 345219004652 ATP-binding site [chemical binding]; other site 345219004653 Rhomboid family; Region: Rhomboid; pfam01694 345219004654 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 345219004655 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 345219004656 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 345219004657 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 345219004658 active site 345219004659 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 345219004660 dimer interface [polypeptide binding]; other site 345219004661 substrate binding site [chemical binding]; other site 345219004662 catalytic residues [active] 345219004663 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 345219004664 PemK-like protein; Region: PemK; pfam02452 345219004665 Rsbr N terminal; Region: Rsbr_N; pfam08678 345219004666 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 345219004667 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 345219004668 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 345219004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219004670 ATP binding site [chemical binding]; other site 345219004671 Mg2+ binding site [ion binding]; other site 345219004672 G-X-G motif; other site 345219004673 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 345219004674 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 345219004675 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 345219004676 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 345219004677 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 345219004678 anti sigma factor interaction site; other site 345219004679 regulatory phosphorylation site [posttranslational modification]; other site 345219004680 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 345219004681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219004682 ATP binding site [chemical binding]; other site 345219004683 Mg2+ binding site [ion binding]; other site 345219004684 G-X-G motif; other site 345219004685 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 345219004686 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219004687 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 345219004688 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219004689 DNA binding residues [nucleotide binding] 345219004690 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 345219004691 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 345219004692 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 345219004693 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 345219004694 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 345219004695 RNA binding site [nucleotide binding]; other site 345219004696 hypothetical protein; Provisional; Region: PRK04351 345219004697 SprT homologues; Region: SprT; cl01182 345219004698 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 345219004699 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 345219004700 Glycoprotease family; Region: Peptidase_M22; pfam00814 345219004701 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 345219004702 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219004703 Coenzyme A binding pocket [chemical binding]; other site 345219004704 UGMP family protein; Validated; Region: PRK09604 345219004705 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 345219004706 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 345219004707 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 345219004708 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 345219004709 ABC transporter; Region: ABC_tran_2; pfam12848 345219004710 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 345219004711 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 345219004712 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 345219004713 CoA binding domain; Region: CoA_binding; pfam02629 345219004714 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 345219004715 Domain of unknown function (DUF4305); Region: DUF4305; pfam14146 345219004716 CAAX protease self-immunity; Region: Abi; pfam02517 345219004717 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 345219004718 oligomerisation interface [polypeptide binding]; other site 345219004719 mobile loop; other site 345219004720 roof hairpin; other site 345219004721 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 345219004722 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 345219004723 ring oligomerisation interface [polypeptide binding]; other site 345219004724 ATP/Mg binding site [chemical binding]; other site 345219004725 stacking interactions; other site 345219004726 hinge regions; other site 345219004727 Predicted membrane protein [Function unknown]; Region: COG2246 345219004728 GtrA-like protein; Region: GtrA; pfam04138 345219004729 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 345219004730 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 345219004731 Ligand binding site; other site 345219004732 Putative Catalytic site; other site 345219004733 DXD motif; other site 345219004734 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 345219004735 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 345219004736 active site 345219004737 Isochorismatase family; Region: Isochorismatase; pfam00857 345219004738 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 345219004739 catalytic triad [active] 345219004740 conserved cis-peptide bond; other site 345219004741 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 345219004742 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 345219004743 active site 345219004744 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 345219004745 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 345219004746 homodimer interface [polypeptide binding]; other site 345219004747 NAD binding pocket [chemical binding]; other site 345219004748 ATP binding pocket [chemical binding]; other site 345219004749 Mg binding site [ion binding]; other site 345219004750 active-site loop [active] 345219004751 GMP synthase; Reviewed; Region: guaA; PRK00074 345219004752 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 345219004753 AMP/PPi binding site [chemical binding]; other site 345219004754 candidate oxyanion hole; other site 345219004755 catalytic triad [active] 345219004756 potential glutamine specificity residues [chemical binding]; other site 345219004757 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 345219004758 ATP Binding subdomain [chemical binding]; other site 345219004759 Ligand Binding sites [chemical binding]; other site 345219004760 Dimerization subdomain; other site 345219004761 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 345219004762 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219004763 sequence-specific DNA binding site [nucleotide binding]; other site 345219004764 salt bridge; other site 345219004765 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 345219004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 345219004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219004768 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 345219004769 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 345219004770 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 345219004771 ABC-ATPase subunit interface; other site 345219004772 dimer interface [polypeptide binding]; other site 345219004773 putative PBP binding regions; other site 345219004774 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 345219004775 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 345219004776 Walker A/P-loop; other site 345219004777 ATP binding site [chemical binding]; other site 345219004778 Q-loop/lid; other site 345219004779 ABC transporter signature motif; other site 345219004780 Walker B; other site 345219004781 D-loop; other site 345219004782 H-loop/switch region; other site 345219004783 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 345219004784 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 345219004785 intersubunit interface [polypeptide binding]; other site 345219004786 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 345219004787 short chain dehydrogenase; Provisional; Region: PRK06701 345219004788 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 345219004789 NAD binding site [chemical binding]; other site 345219004790 metal binding site [ion binding]; metal-binding site 345219004791 active site 345219004792 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 345219004793 dimerization interface [polypeptide binding]; other site 345219004794 putative active cleft [active] 345219004795 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 345219004796 Sulphur transport; Region: Sulf_transp; pfam04143 345219004797 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219004798 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219004799 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219004800 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 345219004801 CPxP motif; other site 345219004802 Lysine efflux permease [General function prediction only]; Region: COG1279 345219004803 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 345219004804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219004805 DNA-binding site [nucleotide binding]; DNA binding site 345219004806 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219004807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219004808 homodimer interface [polypeptide binding]; other site 345219004809 catalytic residue [active] 345219004810 Predicted transcriptional regulator [Transcription]; Region: COG1959 345219004811 Transcriptional regulator; Region: Rrf2; pfam02082 345219004812 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 345219004813 NADH(P)-binding; Region: NAD_binding_10; pfam13460 345219004814 NAD binding site [chemical binding]; other site 345219004815 substrate binding site [chemical binding]; other site 345219004816 putative active site [active] 345219004817 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 345219004818 Predicted transcriptional regulators [Transcription]; Region: COG1695 345219004819 Transcriptional regulator PadR-like family; Region: PadR; cl17335 345219004820 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 345219004821 Predicted transcriptional regulators [Transcription]; Region: COG1725 345219004822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219004823 DNA-binding site [nucleotide binding]; DNA binding site 345219004824 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 345219004825 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219004826 Walker A/P-loop; other site 345219004827 ATP binding site [chemical binding]; other site 345219004828 Q-loop/lid; other site 345219004829 ABC transporter signature motif; other site 345219004830 Walker B; other site 345219004831 D-loop; other site 345219004832 H-loop/switch region; other site 345219004833 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 345219004834 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 345219004835 transmembrane helices; other site 345219004836 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 345219004837 Cupin domain; Region: Cupin_2; pfam07883 345219004838 Cupin domain; Region: Cupin_2; pfam07883 345219004839 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 345219004840 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 345219004841 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 345219004842 Transcriptional regulator [Transcription]; Region: IclR; COG1414 345219004843 Bacterial transcriptional regulator; Region: IclR; pfam01614 345219004844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219004845 benzoate transport; Region: 2A0115; TIGR00895 345219004846 putative substrate translocation pore; other site 345219004847 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 345219004848 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 345219004849 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 345219004850 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 345219004851 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 345219004852 substrate binding site [chemical binding]; other site 345219004853 oxyanion hole (OAH) forming residues; other site 345219004854 trimer interface [polypeptide binding]; other site 345219004855 putative acyltransferase; Provisional; Region: PRK05790 345219004856 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 345219004857 dimer interface [polypeptide binding]; other site 345219004858 active site 345219004859 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 345219004860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 345219004861 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 345219004862 acyl-activating enzyme (AAE) consensus motif; other site 345219004863 acyl-activating enzyme (AAE) consensus motif; other site 345219004864 putative AMP binding site [chemical binding]; other site 345219004865 putative active site [active] 345219004866 putative CoA binding site [chemical binding]; other site 345219004867 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 345219004868 active site 345219004869 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 345219004870 Transcriptional regulator [Transcription]; Region: IclR; COG1414 345219004871 Bacterial transcriptional regulator; Region: IclR; pfam01614 345219004872 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 345219004873 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 345219004874 DinB family; Region: DinB; cl17821 345219004875 DinB superfamily; Region: DinB_2; pfam12867 345219004876 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 345219004877 Cupin domain; Region: Cupin_2; pfam07883 345219004878 Cupin domain; Region: Cupin_2; pfam07883 345219004879 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 345219004880 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 345219004881 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 345219004882 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 345219004883 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219004884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219004885 Walker A/P-loop; other site 345219004886 ATP binding site [chemical binding]; other site 345219004887 Q-loop/lid; other site 345219004888 ABC transporter signature motif; other site 345219004889 Walker B; other site 345219004890 D-loop; other site 345219004891 H-loop/switch region; other site 345219004892 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 345219004893 Histidine kinase; Region: HisKA_3; pfam07730 345219004894 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 345219004895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219004896 active site 345219004897 phosphorylation site [posttranslational modification] 345219004898 intermolecular recognition site; other site 345219004899 dimerization interface [polypeptide binding]; other site 345219004900 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 345219004901 DNA binding residues [nucleotide binding] 345219004902 dimerization interface [polypeptide binding]; other site 345219004903 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 345219004904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219004905 putative substrate translocation pore; other site 345219004906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219004907 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219004908 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 345219004909 Walker A/P-loop; other site 345219004910 ATP binding site [chemical binding]; other site 345219004911 Q-loop/lid; other site 345219004912 ABC transporter signature motif; other site 345219004913 Walker B; other site 345219004914 D-loop; other site 345219004915 H-loop/switch region; other site 345219004916 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 345219004917 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 345219004918 CAT RNA binding domain; Region: CAT_RBD; smart01061 345219004919 transcriptional antiterminator BglG; Provisional; Region: PRK09772 345219004920 PRD domain; Region: PRD; pfam00874 345219004921 PRD domain; Region: PRD; pfam00874 345219004922 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 345219004923 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 345219004924 active site turn [active] 345219004925 phosphorylation site [posttranslational modification] 345219004926 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 345219004927 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 345219004928 HPr interaction site; other site 345219004929 glycerol kinase (GK) interaction site [polypeptide binding]; other site 345219004930 active site 345219004931 phosphorylation site [posttranslational modification] 345219004932 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 345219004933 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 345219004934 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 345219004935 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 345219004936 catalytic residues [active] 345219004937 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4843 345219004938 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 345219004939 NETI protein; Region: NETI; pfam14044 345219004940 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 345219004941 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 345219004942 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 345219004943 NAD binding site [chemical binding]; other site 345219004944 ATP-grasp domain; Region: ATP-grasp; pfam02222 345219004945 adenylosuccinate lyase; Provisional; Region: PRK07492 345219004946 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 345219004947 tetramer interface [polypeptide binding]; other site 345219004948 active site 345219004949 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 345219004950 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 345219004951 ATP binding site [chemical binding]; other site 345219004952 active site 345219004953 substrate binding site [chemical binding]; other site 345219004954 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 345219004955 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 345219004956 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 345219004957 putative active site [active] 345219004958 catalytic triad [active] 345219004959 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 345219004960 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 345219004961 dimerization interface [polypeptide binding]; other site 345219004962 ATP binding site [chemical binding]; other site 345219004963 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 345219004964 dimerization interface [polypeptide binding]; other site 345219004965 ATP binding site [chemical binding]; other site 345219004966 amidophosphoribosyltransferase; Provisional; Region: PRK07631 345219004967 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 345219004968 active site 345219004969 tetramer interface [polypeptide binding]; other site 345219004970 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219004971 active site 345219004972 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 345219004973 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 345219004974 dimerization interface [polypeptide binding]; other site 345219004975 putative ATP binding site [chemical binding]; other site 345219004976 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 345219004977 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 345219004978 active site 345219004979 substrate binding site [chemical binding]; other site 345219004980 cosubstrate binding site; other site 345219004981 catalytic site [active] 345219004982 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 345219004983 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 345219004984 purine monophosphate binding site [chemical binding]; other site 345219004985 dimer interface [polypeptide binding]; other site 345219004986 putative catalytic residues [active] 345219004987 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 345219004988 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 345219004989 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 345219004990 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 345219004991 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 345219004992 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 345219004993 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 345219004994 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 345219004995 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 345219004996 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 345219004997 active site 345219004998 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 345219004999 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 345219005000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 345219005001 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 345219005002 substrate binding site [chemical binding]; other site 345219005003 putative active site [active] 345219005004 dimer interface [polypeptide binding]; other site 345219005005 Part of AAA domain; Region: AAA_19; pfam13245 345219005006 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 345219005007 Family description; Region: UvrD_C_2; pfam13538 345219005008 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 345219005009 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 345219005010 nucleotide binding pocket [chemical binding]; other site 345219005011 K-X-D-G motif; other site 345219005012 catalytic site [active] 345219005013 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 345219005014 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 345219005015 Helix-hairpin-helix motif; Region: HHH; pfam00633 345219005016 helix-hairpin-helix signature motif; other site 345219005017 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 345219005018 Dimer interface [polypeptide binding]; other site 345219005019 Protein involved in sex pheromone biosynthesis [General function prediction only]; Region: CamS; COG4851 345219005020 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 345219005021 putative dimer interface [polypeptide binding]; other site 345219005022 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 345219005023 putative dimer interface [polypeptide binding]; other site 345219005024 malate synthase A; Region: malate_syn_A; TIGR01344 345219005025 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 345219005026 active site 345219005027 isocitrate lyase; Provisional; Region: PRK15063 345219005028 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 345219005029 tetramer interface [polypeptide binding]; other site 345219005030 active site 345219005031 Mg2+/Mn2+ binding site [ion binding]; other site 345219005032 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 345219005033 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 345219005034 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 345219005035 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 345219005036 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 345219005037 GatB domain; Region: GatB_Yqey; smart00845 345219005038 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 345219005039 General stress protein [General function prediction only]; Region: GsiB; COG3729 345219005040 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 345219005041 putative lipid kinase; Reviewed; Region: PRK13337 345219005042 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 345219005043 putative transporter; Provisional; Region: PRK10484 345219005044 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 345219005045 Na binding site [ion binding]; other site 345219005046 TRAM domain; Region: TRAM; pfam01938 345219005047 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 345219005048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219005049 S-adenosylmethionine binding site [chemical binding]; other site 345219005050 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 345219005051 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219005052 RNA binding surface [nucleotide binding]; other site 345219005053 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 345219005054 Transposase [DNA replication, recombination, and repair]; Region: COG5421 345219005055 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 345219005056 catalytic triad [active] 345219005057 DDE superfamily endonuclease; Region: DDE_5; cl17874 345219005058 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005059 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 345219005060 Walker A motif; other site 345219005061 ATP binding site [chemical binding]; other site 345219005062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 345219005063 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 345219005064 active pocket/dimerization site; other site 345219005065 active site 345219005066 phosphorylation site [posttranslational modification] 345219005067 PRD domain; Region: PRD; pfam00874 345219005068 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 345219005069 active pocket/dimerization site; other site 345219005070 active site 345219005071 phosphorylation site [posttranslational modification] 345219005072 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 345219005073 active site 345219005074 phosphorylation site [posttranslational modification] 345219005075 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 345219005076 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 345219005077 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 345219005078 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 345219005079 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 345219005080 Transposase [DNA replication, recombination, and repair]; Region: COG5421 345219005081 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 345219005082 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 345219005083 Protein of unknown function; Region: DUF3658; pfam12395 345219005084 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 345219005085 acetoin reductases; Region: 23BDH; TIGR02415 345219005086 NAD binding site [chemical binding]; other site 345219005087 homotetramer interface [polypeptide binding]; other site 345219005088 homodimer interface [polypeptide binding]; other site 345219005089 active site 345219005090 substrate binding site [chemical binding]; other site 345219005091 Protein of unknown function (DUF2750); Region: DUF2750; pfam11042 345219005092 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 345219005093 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 345219005094 NAD binding site [chemical binding]; other site 345219005095 substrate binding site [chemical binding]; other site 345219005096 catalytic Zn binding site [ion binding]; other site 345219005097 tetramer interface [polypeptide binding]; other site 345219005098 structural Zn binding site [ion binding]; other site 345219005099 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 345219005100 active site 345219005101 NTP binding site [chemical binding]; other site 345219005102 metal binding triad [ion binding]; metal-binding site 345219005103 antibiotic binding site [chemical binding]; other site 345219005104 Protein of unknown function DUF86; Region: DUF86; pfam01934 345219005105 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 345219005106 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 345219005107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219005108 S-adenosylmethionine binding site [chemical binding]; other site 345219005109 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 345219005110 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 345219005111 active site 345219005112 intersubunit interface [polypeptide binding]; other site 345219005113 catalytic residue [active] 345219005114 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 345219005115 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 345219005116 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 345219005117 Protein of unknown function (DUF1653); Region: DUF1653; cl01949 345219005118 heat shock protein 90; Provisional; Region: PRK05218 345219005119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219005120 ATP binding site [chemical binding]; other site 345219005121 Mg2+ binding site [ion binding]; other site 345219005122 G-X-G motif; other site 345219005123 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 345219005124 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 345219005125 metal binding site [ion binding]; metal-binding site 345219005126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219005127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 345219005128 substrate binding pocket [chemical binding]; other site 345219005129 membrane-bound complex binding site; other site 345219005130 hinge residues; other site 345219005131 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 345219005132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219005133 dimer interface [polypeptide binding]; other site 345219005134 conserved gate region; other site 345219005135 putative PBP binding loops; other site 345219005136 ABC-ATPase subunit interface; other site 345219005137 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 345219005138 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 345219005139 Walker A/P-loop; other site 345219005140 ATP binding site [chemical binding]; other site 345219005141 Q-loop/lid; other site 345219005142 ABC transporter signature motif; other site 345219005143 Walker B; other site 345219005144 D-loop; other site 345219005145 H-loop/switch region; other site 345219005146 peroxiredoxin, SACOL1771 subfamily; Region: perox_SACOL1771; TIGR03563 345219005147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219005149 putative substrate translocation pore; other site 345219005150 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 345219005151 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 345219005152 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 345219005153 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 345219005154 putative active site [active] 345219005155 Protein of unknown function (DUF969); Region: DUF969; pfam06149 345219005156 Predicted membrane protein [Function unknown]; Region: COG3817 345219005157 Protein of unknown function (DUF979); Region: DUF979; pfam06166 345219005158 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 345219005159 putative substrate binding pocket [chemical binding]; other site 345219005160 AC domain interface; other site 345219005161 catalytic triad [active] 345219005162 AB domain interface; other site 345219005163 interchain disulfide; other site 345219005164 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 345219005165 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 345219005166 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 345219005167 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 345219005168 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 345219005169 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 345219005170 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 345219005171 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 345219005172 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 345219005173 phosphopentomutase; Provisional; Region: PRK05362 345219005174 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 345219005175 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 345219005176 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 345219005177 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 345219005178 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 345219005179 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 345219005180 intersubunit interface [polypeptide binding]; other site 345219005181 active site 345219005182 catalytic residue [active] 345219005183 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 345219005184 active site 345219005185 catalytic motif [active] 345219005186 Zn binding site [ion binding]; other site 345219005187 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 345219005188 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 345219005189 THF binding site; other site 345219005190 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 345219005191 substrate binding site [chemical binding]; other site 345219005192 THF binding site; other site 345219005193 zinc-binding site [ion binding]; other site 345219005194 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 345219005195 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 345219005196 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 345219005197 active site 345219005198 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 345219005199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219005200 substrate binding pocket [chemical binding]; other site 345219005201 membrane-bound complex binding site; other site 345219005202 hinge residues; other site 345219005203 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 345219005204 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 345219005205 active site 345219005206 dimer interface [polypeptide binding]; other site 345219005207 non-prolyl cis peptide bond; other site 345219005208 insertion regions; other site 345219005209 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 345219005210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219005211 dimer interface [polypeptide binding]; other site 345219005212 conserved gate region; other site 345219005213 putative PBP binding loops; other site 345219005214 ABC-ATPase subunit interface; other site 345219005215 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 345219005216 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 345219005217 Walker A/P-loop; other site 345219005218 ATP binding site [chemical binding]; other site 345219005219 Q-loop/lid; other site 345219005220 ABC transporter signature motif; other site 345219005221 Walker B; other site 345219005222 D-loop; other site 345219005223 H-loop/switch region; other site 345219005224 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 345219005225 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 345219005226 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 345219005227 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 345219005228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219005229 Coenzyme A binding pocket [chemical binding]; other site 345219005230 Predicted amidohydrolase [General function prediction only]; Region: COG0388 345219005231 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 345219005232 putative active site [active] 345219005233 catalytic triad [active] 345219005234 putative dimer interface [polypeptide binding]; other site 345219005235 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 345219005236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 345219005237 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 345219005238 Protein of unknown function (DUF524); Region: DUF524; pfam04411 345219005239 Membrane transport protein; Region: Mem_trans; cl09117 345219005240 Integral membrane protein TerC family; Region: TerC; cl10468 345219005241 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 345219005242 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219005243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005244 putative substrate translocation pore; other site 345219005245 amidase; Provisional; Region: PRK07487 345219005246 Amidase; Region: Amidase; pfam01425 345219005247 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 345219005248 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 345219005249 substrate binding pocket [chemical binding]; other site 345219005250 catalytic triad [active] 345219005251 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 345219005252 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 345219005253 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219005254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219005255 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219005256 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 345219005257 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 345219005258 NlpC/P60 family; Region: NLPC_P60; pfam00877 345219005259 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 345219005260 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 345219005261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219005262 active site 345219005263 motif I; other site 345219005264 motif II; other site 345219005265 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 345219005266 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219005267 putative Zn2+ binding site [ion binding]; other site 345219005268 putative DNA binding site [nucleotide binding]; other site 345219005269 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219005270 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219005271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219005272 Walker A/P-loop; other site 345219005273 ATP binding site [chemical binding]; other site 345219005274 Q-loop/lid; other site 345219005275 ABC transporter signature motif; other site 345219005276 Walker B; other site 345219005277 D-loop; other site 345219005278 H-loop/switch region; other site 345219005279 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219005280 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219005281 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 345219005282 Walker A/P-loop; other site 345219005283 ATP binding site [chemical binding]; other site 345219005284 Q-loop/lid; other site 345219005285 ABC transporter signature motif; other site 345219005286 Walker B; other site 345219005287 D-loop; other site 345219005288 H-loop/switch region; other site 345219005289 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 345219005290 Beta-lactamase; Region: Beta-lactamase; cl17358 345219005291 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 345219005292 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 345219005293 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 345219005294 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 345219005295 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 345219005296 Protein of unknown function, DUF606; Region: DUF606; pfam04657 345219005297 Protein of unknown function, DUF606; Region: DUF606; pfam04657 345219005298 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 345219005299 DNA-binding site [nucleotide binding]; DNA binding site 345219005300 RNA-binding motif; other site 345219005301 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219005302 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 345219005303 AIR carboxylase; Region: AIRC; smart01001 345219005304 hypothetical protein; Provisional; Region: PRK04194 345219005305 Protein of unknown function DUF111; Region: DUF111; cl03398 345219005306 fructuronate transporter; Provisional; Region: PRK10034; cl15264 345219005307 gluconate transporter; Region: gntP; TIGR00791 345219005308 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 345219005309 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 345219005310 Ligand Binding Site [chemical binding]; other site 345219005311 Propionate catabolism activator; Region: PrpR_N; pfam06506 345219005312 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 345219005313 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 345219005314 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219005315 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 345219005316 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 345219005317 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 345219005318 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 345219005319 High-affinity nickel-transport protein; Region: NicO; cl00964 345219005320 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 345219005321 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 345219005322 active site 345219005323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219005324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 345219005325 dimer interface [polypeptide binding]; other site 345219005326 phosphorylation site [posttranslational modification] 345219005327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219005328 ATP binding site [chemical binding]; other site 345219005329 Mg2+ binding site [ion binding]; other site 345219005330 G-X-G motif; other site 345219005331 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 345219005332 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 345219005333 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219005334 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219005335 DNA binding site [nucleotide binding] 345219005336 domain linker motif; other site 345219005337 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 345219005338 dimerization interface [polypeptide binding]; other site 345219005339 ligand binding site [chemical binding]; other site 345219005340 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 345219005341 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 345219005342 substrate binding site [chemical binding]; other site 345219005343 hexamer interface [polypeptide binding]; other site 345219005344 metal binding site [ion binding]; metal-binding site 345219005345 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 345219005346 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 345219005347 substrate binding site [chemical binding]; other site 345219005348 dimer interface [polypeptide binding]; other site 345219005349 ATP binding site [chemical binding]; other site 345219005350 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219005351 CopC domain; Region: CopC; pfam04234 345219005352 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 345219005353 YtkA-like; Region: YtkA; pfam13115 345219005354 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 345219005355 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219005356 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 345219005357 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219005358 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219005359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219005360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219005361 DNA binding site [nucleotide binding] 345219005362 domain linker motif; other site 345219005363 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 345219005364 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 345219005365 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 345219005366 substrate binding site [chemical binding]; other site 345219005367 dimer interface [polypeptide binding]; other site 345219005368 ATP binding site [chemical binding]; other site 345219005369 D-ribose pyranase; Provisional; Region: PRK11797 345219005370 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 345219005371 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 345219005372 Walker A/P-loop; other site 345219005373 ATP binding site [chemical binding]; other site 345219005374 Q-loop/lid; other site 345219005375 ABC transporter signature motif; other site 345219005376 Walker B; other site 345219005377 D-loop; other site 345219005378 H-loop/switch region; other site 345219005379 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 345219005380 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 345219005381 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 345219005382 TM-ABC transporter signature motif; other site 345219005383 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 345219005384 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 345219005385 ligand binding site [chemical binding]; other site 345219005386 dimerization interface [polypeptide binding]; other site 345219005387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219005388 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219005389 Probable transposase; Region: OrfB_IS605; pfam01385 345219005390 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 345219005391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219005392 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219005393 Probable transposase; Region: OrfB_IS605; pfam01385 345219005394 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 345219005395 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 345219005396 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 345219005397 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 345219005398 putative NAD(P) binding site [chemical binding]; other site 345219005399 catalytic Zn binding site [ion binding]; other site 345219005400 hypothetical protein; Provisional; Region: PRK06851 345219005401 NTPase; Region: NTPase_1; cl17478 345219005402 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 345219005403 G1 box; other site 345219005404 GTP/Mg2+ binding site [chemical binding]; other site 345219005405 G2 box; other site 345219005406 Switch I region; other site 345219005407 G3 box; other site 345219005408 Switch II region; other site 345219005409 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 345219005410 Class III ribonucleotide reductase; Region: RNR_III; cd01675 345219005411 effector binding site; other site 345219005412 active site 345219005413 Zn binding site [ion binding]; other site 345219005414 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 345219005415 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219005416 FeS/SAM binding site; other site 345219005417 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 345219005418 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 345219005419 HsdM N-terminal domain; Region: HsdM_N; pfam12161 345219005420 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 345219005421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 345219005422 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 345219005423 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219005424 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 345219005425 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219005426 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 345219005427 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 345219005428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219005429 ATP binding site [chemical binding]; other site 345219005430 putative Mg++ binding site [ion binding]; other site 345219005431 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 345219005432 Protein of unknown function DUF45; Region: DUF45; pfam01863 345219005433 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 345219005434 FIC domain binding interface [polypeptide binding]; other site 345219005435 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219005436 dimerization interface [polypeptide binding]; other site 345219005437 putative DNA binding site [nucleotide binding]; other site 345219005438 putative Zn2+ binding site [ion binding]; other site 345219005439 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 345219005440 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 345219005441 metal-binding site [ion binding] 345219005442 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 345219005443 Soluble P-type ATPase [General function prediction only]; Region: COG4087 345219005444 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 345219005445 YqcI/YcgG family; Region: YqcI_YcgG; cl01349 345219005446 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 345219005447 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005448 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 345219005449 putative dimer interface [polypeptide binding]; other site 345219005450 catalytic triad [active] 345219005451 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005452 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 345219005453 Transposase domain (DUF772); Region: DUF772; pfam05598 345219005454 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 345219005455 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005456 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 345219005457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 345219005458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 345219005459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 345219005460 dimerization interface [polypeptide binding]; other site 345219005461 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 345219005462 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 345219005463 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 345219005464 putative active site [active] 345219005465 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 345219005466 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 345219005467 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 345219005468 active site turn [active] 345219005469 phosphorylation site [posttranslational modification] 345219005470 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 345219005471 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 345219005472 NAD binding site [chemical binding]; other site 345219005473 sugar binding site [chemical binding]; other site 345219005474 divalent metal binding site [ion binding]; other site 345219005475 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219005476 dimer interface [polypeptide binding]; other site 345219005477 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 345219005478 HPr interaction site; other site 345219005479 glycerol kinase (GK) interaction site [polypeptide binding]; other site 345219005480 active site 345219005481 phosphorylation site [posttranslational modification] 345219005482 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 345219005483 catalytic residues [active] 345219005484 dimer interface [polypeptide binding]; other site 345219005485 LysE type translocator; Region: LysE; pfam01810 345219005486 HsdM N-terminal domain; Region: HsdM_N; pfam12161 345219005487 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 345219005488 Methyltransferase domain; Region: Methyltransf_26; pfam13659 345219005489 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219005490 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 345219005491 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219005492 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 345219005493 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 345219005494 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219005495 ATP binding site [chemical binding]; other site 345219005496 putative Mg++ binding site [ion binding]; other site 345219005497 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 345219005498 EVE domain; Region: EVE; pfam01878 345219005499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219005500 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 345219005501 Walker A motif; other site 345219005502 ATP binding site [chemical binding]; other site 345219005503 Walker B motif; other site 345219005504 arginine finger; other site 345219005505 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 345219005506 Protein of unknown function, DUF600; Region: DUF600; cl04640 345219005507 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 345219005508 Transposase domain (DUF772); Region: DUF772; pfam05598 345219005509 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 345219005510 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 345219005511 LXG domain of WXG superfamily; Region: LXG; pfam04740 345219005512 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 345219005513 antitoxin MqsA for MqsR toxin; Region: MqsA; cl15819 345219005514 toxin interface [polypeptide binding]; other site 345219005515 Zn binding site [ion binding]; other site 345219005516 hydroperoxidase II; Provisional; Region: katE; PRK11249 345219005517 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 345219005518 tetramer interface [polypeptide binding]; other site 345219005519 heme binding pocket [chemical binding]; other site 345219005520 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 345219005521 domain interactions; other site 345219005522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 345219005523 Walker A/P-loop; other site 345219005524 ATP binding site [chemical binding]; other site 345219005525 Q-loop/lid; other site 345219005526 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cd00188 345219005527 active site 345219005528 metal binding site [ion binding]; metal-binding site 345219005529 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 345219005530 active site 345219005531 catalytic residues [active] 345219005532 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219005533 Coenzyme A binding pocket [chemical binding]; other site 345219005534 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 345219005535 putative active site [active] 345219005536 catalytic residue [active] 345219005537 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 345219005538 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 345219005539 transmembrane helices; other site 345219005540 malate dehydrogenase; Provisional; Region: PRK13529 345219005541 Malic enzyme, N-terminal domain; Region: malic; pfam00390 345219005542 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 345219005543 NAD(P) binding site [chemical binding]; other site 345219005544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005545 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 345219005546 putative substrate translocation pore; other site 345219005547 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 345219005548 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 345219005549 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 345219005550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 345219005551 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 345219005552 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 345219005553 [4Fe-4S] binding site [ion binding]; other site 345219005554 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 345219005555 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 345219005556 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 345219005557 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 345219005558 molybdopterin cofactor binding site; other site 345219005559 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 345219005560 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219005561 Walker A/P-loop; other site 345219005562 ATP binding site [chemical binding]; other site 345219005563 Q-loop/lid; other site 345219005564 ABC transporter signature motif; other site 345219005565 Walker B; other site 345219005566 D-loop; other site 345219005567 H-loop/switch region; other site 345219005568 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 345219005569 ABC-2 type transporter; Region: ABC2_membrane; cl17235 345219005570 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219005571 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219005572 lysine transporter; Provisional; Region: PRK10836 345219005573 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 345219005574 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 345219005575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219005576 ATP binding site [chemical binding]; other site 345219005577 putative Mg++ binding site [ion binding]; other site 345219005578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 345219005579 HsdM N-terminal domain; Region: HsdM_N; pfam12161 345219005580 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 345219005581 Methyltransferase domain; Region: Methyltransf_26; pfam13659 345219005582 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 345219005583 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219005584 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 345219005585 PAS fold; Region: PAS_4; pfam08448 345219005586 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 345219005587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219005588 Walker A motif; other site 345219005589 ATP binding site [chemical binding]; other site 345219005590 Walker B motif; other site 345219005591 arginine finger; other site 345219005592 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219005593 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 345219005594 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219005595 inhibitor-cofactor binding pocket; inhibition site 345219005596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219005597 catalytic residue [active] 345219005598 PAS domain; Region: PAS; smart00091 345219005599 PAS domain; Region: PAS_9; pfam13426 345219005600 putative active site [active] 345219005601 heme pocket [chemical binding]; other site 345219005602 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 345219005603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219005604 Walker A motif; other site 345219005605 ATP binding site [chemical binding]; other site 345219005606 Walker B motif; other site 345219005607 arginine finger; other site 345219005608 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219005609 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 345219005610 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 345219005611 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 345219005612 acyl-activating enzyme (AAE) consensus motif; other site 345219005613 putative AMP binding site [chemical binding]; other site 345219005614 putative active site [active] 345219005615 putative CoA binding site [chemical binding]; other site 345219005616 acetyl-CoA synthetase; Provisional; Region: PRK00174 345219005617 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 345219005618 acyl-activating enzyme (AAE) consensus motif; other site 345219005619 AMP binding site [chemical binding]; other site 345219005620 active site 345219005621 CoA binding site [chemical binding]; other site 345219005622 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219005623 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 345219005624 FAD binding site [chemical binding]; other site 345219005625 homotetramer interface [polypeptide binding]; other site 345219005626 substrate binding pocket [chemical binding]; other site 345219005627 catalytic base [active] 345219005628 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 345219005629 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219005630 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 345219005631 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 345219005632 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 345219005633 carboxyltransferase (CT) interaction site; other site 345219005634 biotinylation site [posttranslational modification]; other site 345219005635 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 345219005636 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 345219005637 active site 345219005638 catalytic residues [active] 345219005639 metal binding site [ion binding]; metal-binding site 345219005640 enoyl-CoA hydratase; Provisional; Region: PRK07657 345219005641 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 345219005642 substrate binding site [chemical binding]; other site 345219005643 oxyanion hole (OAH) forming residues; other site 345219005644 trimer interface [polypeptide binding]; other site 345219005645 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 345219005646 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 345219005647 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 345219005648 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 345219005649 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219005650 Coenzyme A binding pocket [chemical binding]; other site 345219005651 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 345219005652 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219005653 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 345219005654 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 345219005655 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 345219005656 Part of AAA domain; Region: AAA_19; pfam13245 345219005657 Family description; Region: UvrD_C_2; pfam13538 345219005658 putative uracil/xanthine transporter; Provisional; Region: PRK11412 345219005659 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 345219005660 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 345219005661 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 345219005662 dimer interface [polypeptide binding]; other site 345219005663 FMN binding site [chemical binding]; other site 345219005664 NADPH bind site [chemical binding]; other site 345219005665 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 345219005666 Type I periplasmic components of amide-binding protein (AmiC) and the active transport system for short-chain and urea (FmdDEF); Region: PBP1_AmiC_like; cd06331 345219005667 ligand binding site [chemical binding]; other site 345219005668 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 345219005669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219005670 Walker A motif; other site 345219005671 ATP binding site [chemical binding]; other site 345219005672 Walker B motif; other site 345219005673 arginine finger; other site 345219005674 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219005675 acylamide amidohydrolase; Provisional; Region: amiE; PRK13286 345219005676 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 345219005677 multimer interface [polypeptide binding]; other site 345219005678 active site 345219005679 catalytic triad [active] 345219005680 dimer interface [polypeptide binding]; other site 345219005681 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 345219005682 Na binding site [ion binding]; other site 345219005683 formamidase; Provisional; Region: amiF; PRK13287 345219005684 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 345219005685 multimer interface [polypeptide binding]; other site 345219005686 active site 345219005687 catalytic triad [active] 345219005688 dimer interface [polypeptide binding]; other site 345219005689 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 345219005690 alpha-gamma subunit interface [polypeptide binding]; other site 345219005691 beta-gamma subunit interface [polypeptide binding]; other site 345219005692 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 345219005693 gamma-beta subunit interface [polypeptide binding]; other site 345219005694 alpha-beta subunit interface [polypeptide binding]; other site 345219005695 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219005696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219005697 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219005698 urease subunit alpha; Reviewed; Region: ureC; PRK13207 345219005699 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 345219005700 subunit interactions [polypeptide binding]; other site 345219005701 active site 345219005702 flap region; other site 345219005703 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 345219005704 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 345219005705 dimer interface [polypeptide binding]; other site 345219005706 catalytic residues [active] 345219005707 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 345219005708 UreF; Region: UreF; pfam01730 345219005709 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 345219005710 UreD urease accessory protein; Region: UreD; pfam01774 345219005711 High-affinity nickel-transport protein; Region: NicO; cl00964 345219005712 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 345219005713 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 345219005714 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 345219005715 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 345219005716 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 345219005717 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 345219005718 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219005719 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219005720 active site 345219005721 catalytic tetrad [active] 345219005722 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 345219005723 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219005724 inhibitor-cofactor binding pocket; inhibition site 345219005725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219005726 catalytic residue [active] 345219005727 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 345219005728 synthetase active site [active] 345219005729 NTP binding site [chemical binding]; other site 345219005730 metal binding site [ion binding]; metal-binding site 345219005731 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 345219005732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219005733 FeS/SAM binding site; other site 345219005734 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 345219005735 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005736 putative substrate translocation pore; other site 345219005737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005738 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 345219005739 HPr interaction site; other site 345219005740 glycerol kinase (GK) interaction site [polypeptide binding]; other site 345219005741 active site 345219005742 phosphorylation site [posttranslational modification] 345219005743 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 345219005744 sugar phosphate phosphatase; Provisional; Region: PRK10513 345219005745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219005746 active site 345219005747 motif I; other site 345219005748 motif II; other site 345219005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219005750 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 345219005751 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 345219005752 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 345219005753 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 345219005754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219005755 ATP binding site [chemical binding]; other site 345219005756 putative Mg++ binding site [ion binding]; other site 345219005757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 345219005758 nucleotide binding region [chemical binding]; other site 345219005759 ATP-binding site [chemical binding]; other site 345219005760 Hemerythrin-like domain; Region: Hr-like; cd12108 345219005761 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 345219005762 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 345219005763 dimer interface [polypeptide binding]; other site 345219005764 active site 345219005765 metal binding site [ion binding]; metal-binding site 345219005766 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 345219005767 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 345219005768 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 345219005769 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 345219005770 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 345219005771 active site 345219005772 phosphorylation site [posttranslational modification] 345219005773 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 345219005774 active site 345219005775 P-loop; other site 345219005776 phosphorylation site [posttranslational modification] 345219005777 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 345219005778 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 345219005779 Helix-turn-helix domain; Region: HTH_17; cl17695 345219005780 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 345219005781 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 345219005782 putative active site cavity [active] 345219005783 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 345219005784 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 345219005785 homotetramer interface [polypeptide binding]; other site 345219005786 FMN binding site [chemical binding]; other site 345219005787 homodimer contacts [polypeptide binding]; other site 345219005788 putative active site [active] 345219005789 putative substrate binding site [chemical binding]; other site 345219005790 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 345219005791 putative FMN binding site [chemical binding]; other site 345219005792 SWIM zinc finger; Region: SWIM; pfam04434 345219005793 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 345219005794 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 345219005795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219005796 ATP binding site [chemical binding]; other site 345219005797 putative Mg++ binding site [ion binding]; other site 345219005798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219005799 nucleotide binding region [chemical binding]; other site 345219005800 ATP-binding site [chemical binding]; other site 345219005801 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 345219005802 Family of unknown function (DUF694); Region: DUF694; pfam05107 345219005803 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 345219005804 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 345219005805 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 345219005806 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 345219005807 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219005808 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 345219005809 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 345219005810 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 345219005811 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005812 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 345219005813 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 345219005814 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 345219005815 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 345219005816 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005817 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 345219005818 Transposase; Region: HTH_Tnp_1; pfam01527 345219005819 putative transposase OrfB; Reviewed; Region: PHA02517 345219005820 HTH-like domain; Region: HTH_21; pfam13276 345219005821 Integrase core domain; Region: rve; pfam00665 345219005822 Integrase core domain; Region: rve_3; pfam13683 345219005823 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 345219005824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219005825 non-specific DNA binding site [nucleotide binding]; other site 345219005826 salt bridge; other site 345219005827 sequence-specific DNA binding site [nucleotide binding]; other site 345219005828 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 345219005829 catalytic core [active] 345219005830 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 345219005831 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 345219005832 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 345219005833 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 345219005834 active site 345219005835 metal binding site [ion binding]; metal-binding site 345219005836 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 345219005837 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 345219005838 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 345219005839 putative active site [active] 345219005840 Predicted secreted protein [Function unknown]; Region: COG4086 345219005841 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 345219005842 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 345219005843 LuxR family transcriptional regulatory, chaperone HchA-associated; Region: reg_near_HchA; TIGR03541 345219005844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 345219005845 DNA binding residues [nucleotide binding] 345219005846 dimerization interface [polypeptide binding]; other site 345219005847 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 345219005848 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 345219005849 active site 345219005850 metal binding site [ion binding]; metal-binding site 345219005851 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 345219005852 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219005853 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 345219005854 active site clefts [active] 345219005855 zinc binding site [ion binding]; other site 345219005856 dimer interface [polypeptide binding]; other site 345219005857 Methyltransferase domain; Region: Methyltransf_23; pfam13489 345219005858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219005859 S-adenosylmethionine binding site [chemical binding]; other site 345219005860 S-ribosylhomocysteinase; Provisional; Region: PRK02260 345219005861 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 345219005862 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 345219005863 dimer interface [polypeptide binding]; other site 345219005864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219005865 catalytic residue [active] 345219005866 cystathionine beta-lyase; Provisional; Region: PRK07671 345219005867 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 345219005868 homodimer interface [polypeptide binding]; other site 345219005869 substrate-cofactor binding pocket; other site 345219005870 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219005871 catalytic residue [active] 345219005872 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 345219005873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 345219005874 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 345219005875 rod-share determining protein MreBH; Provisional; Region: PRK13929 345219005876 MreB and similar proteins; Region: MreB_like; cd10225 345219005877 nucleotide binding site [chemical binding]; other site 345219005878 Mg binding site [ion binding]; other site 345219005879 putative protofilament interaction site [polypeptide binding]; other site 345219005880 RodZ interaction site [polypeptide binding]; other site 345219005881 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 345219005882 regulatory protein, yteA family; Region: bacill_yteA; TIGR02890 345219005883 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005884 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219005885 putative substrate translocation pore; other site 345219005886 Protein of unknown function, DUF488; Region: DUF488; cl01246 345219005887 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 345219005888 flagellar motor protein MotA; Validated; Region: PRK08124 345219005889 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 345219005890 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 345219005891 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 345219005892 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 345219005893 ligand binding site [chemical binding]; other site 345219005894 intracellular protease, PfpI family; Region: PfpI; TIGR01382 345219005895 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 345219005896 proposed catalytic triad [active] 345219005897 conserved cys residue [active] 345219005898 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 345219005899 active site 345219005900 Protein of unknown function (DUF1128); Region: DUF1128; pfam06569 345219005901 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 345219005902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219005903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219005904 putative substrate translocation pore; other site 345219005905 calcium/proton exchanger (cax); Region: cax; TIGR00378 345219005906 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 345219005907 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 345219005908 YfkD-like protein; Region: YfkD; pfam14167 345219005909 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 345219005910 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 345219005911 NodB motif; other site 345219005912 active site 345219005913 catalytic site [active] 345219005914 Cd binding site [ion binding]; other site 345219005915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 345219005916 Homeodomain-like domain; Region: HTH_23; pfam13384 345219005917 Winged helix-turn helix; Region: HTH_33; pfam13592 345219005918 DDE superfamily endonuclease; Region: DDE_3; pfam13358 345219005919 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 345219005920 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 345219005921 minor groove reading motif; other site 345219005922 helix-hairpin-helix signature motif; other site 345219005923 substrate binding pocket [chemical binding]; other site 345219005924 active site 345219005925 TRAM domain; Region: TRAM; pfam01938 345219005926 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 345219005927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219005928 S-adenosylmethionine binding site [chemical binding]; other site 345219005929 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 345219005930 GIY-YIG motif/motif A; other site 345219005931 putative active site [active] 345219005932 putative metal binding site [ion binding]; other site 345219005933 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 345219005934 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 345219005935 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219005936 putative Mg++ binding site [ion binding]; other site 345219005937 Recombinase; Region: Recombinase; pfam07508 345219005938 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 345219005939 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 345219005940 catalytic nucleophile [active] 345219005941 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 345219005942 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 345219005943 Recombinase; Region: Recombinase; pfam07508 345219005944 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 345219005945 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 345219005946 Transposase [DNA replication, recombination, and repair]; Region: COG5421 345219005947 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219005948 dimerization interface [polypeptide binding]; other site 345219005949 putative DNA binding site [nucleotide binding]; other site 345219005950 putative Zn2+ binding site [ion binding]; other site 345219005951 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 345219005952 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 345219005953 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 345219005954 P loop; other site 345219005955 Nucleotide binding site [chemical binding]; other site 345219005956 DTAP/Switch II; other site 345219005957 Switch I; other site 345219005958 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 345219005959 P loop; other site 345219005960 Nucleotide binding site [chemical binding]; other site 345219005961 DTAP/Switch II; other site 345219005962 Switch I; other site 345219005963 Domain of unknown function (DUF2703); Region: DUF2703; pfam10865 345219005964 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 345219005965 arsenical-resistance protein; Region: acr3; TIGR00832 345219005966 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 345219005967 Low molecular weight phosphatase family; Region: LMWPc; cd00115 345219005968 active site 345219005969 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 345219005970 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 345219005971 MarR family; Region: MarR_2; pfam12802 345219005972 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219005973 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219005974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219005975 Walker A/P-loop; other site 345219005976 ATP binding site [chemical binding]; other site 345219005977 Q-loop/lid; other site 345219005978 ABC transporter signature motif; other site 345219005979 Walker B; other site 345219005980 D-loop; other site 345219005981 H-loop/switch region; other site 345219005982 recombination factor protein RarA; Reviewed; Region: PRK13342 345219005983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219005984 Walker A motif; other site 345219005985 ATP binding site [chemical binding]; other site 345219005986 Walker B motif; other site 345219005987 arginine finger; other site 345219005988 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 345219005989 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 345219005990 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 345219005991 active site 345219005992 HAMP domain; Region: HAMP; pfam00672 345219005993 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219005994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219005995 dimer interface [polypeptide binding]; other site 345219005996 putative CheW interface [polypeptide binding]; other site 345219005997 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 345219005998 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 345219005999 putative DNA binding site [nucleotide binding]; other site 345219006000 catalytic residue [active] 345219006001 putative H2TH interface [polypeptide binding]; other site 345219006002 putative catalytic residues [active] 345219006003 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 345219006004 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 345219006005 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219006006 RNA binding surface [nucleotide binding]; other site 345219006007 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 345219006008 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 345219006009 FMN binding site [chemical binding]; other site 345219006010 active site 345219006011 catalytic residues [active] 345219006012 substrate binding site [chemical binding]; other site 345219006013 proline/glycine betaine transporter; Provisional; Region: PRK10642 345219006014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006015 putative substrate translocation pore; other site 345219006016 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 345219006017 Predicted kinase [General function prediction only]; Region: COG4639 345219006018 hypothetical protein; Provisional; Region: PRK06762 345219006019 Uncharacterized conserved protein [Function unknown]; Region: COG3402 345219006020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 345219006021 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 345219006022 Probable transposase; Region: OrfB_IS605; pfam01385 345219006023 Predicted membrane protein [Function unknown]; Region: COG3428 345219006024 Bacterial PH domain; Region: DUF304; pfam03703 345219006025 Bacterial PH domain; Region: DUF304; pfam03703 345219006026 Bacterial PH domain; Region: DUF304; pfam03703 345219006027 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219006028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219006029 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219006030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2839 345219006031 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 345219006032 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 345219006033 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 345219006034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219006035 salt bridge; other site 345219006036 non-specific DNA binding site [nucleotide binding]; other site 345219006037 sequence-specific DNA binding site [nucleotide binding]; other site 345219006038 Protein of unknown function (DUF817); Region: DUF817; pfam05675 345219006039 CHASE3 domain; Region: CHASE3; pfam05227 345219006040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219006041 dimerization interface [polypeptide binding]; other site 345219006042 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219006043 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219006044 dimer interface [polypeptide binding]; other site 345219006045 putative CheW interface [polypeptide binding]; other site 345219006046 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 345219006047 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 345219006048 TIGR02680 family protein; Region: TIGR02680 345219006049 P-loop containing region of AAA domain; Region: AAA_29; cl17516 345219006050 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 345219006051 Protein of unknown function (DUF2398); Region: DUF2398; pfam09661 345219006052 TIGR02677 family protein; Region: TIGR02677 345219006053 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 345219006054 Predicted membrane protein [Function unknown]; Region: COG1511 345219006055 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 345219006056 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 345219006057 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219006058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219006059 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 345219006060 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 345219006061 Multicopper oxidase; Region: Cu-oxidase; pfam00394 345219006062 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 345219006063 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 345219006064 active site 345219006065 homodimer interface [polypeptide binding]; other site 345219006066 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 345219006067 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 345219006068 GAF domain; Region: GAF_3; pfam13492 345219006069 Histidine kinase; Region: His_kinase; pfam06580 345219006070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219006071 ATP binding site [chemical binding]; other site 345219006072 Mg2+ binding site [ion binding]; other site 345219006073 G-X-G motif; other site 345219006074 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 345219006075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219006076 active site 345219006077 phosphorylation site [posttranslational modification] 345219006078 intermolecular recognition site; other site 345219006079 dimerization interface [polypeptide binding]; other site 345219006080 LytTr DNA-binding domain; Region: LytTR; pfam04397 345219006081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006082 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 345219006083 putative substrate translocation pore; other site 345219006084 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 345219006085 substrate binding site [chemical binding]; other site 345219006086 THF binding site; other site 345219006087 zinc-binding site [ion binding]; other site 345219006088 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 345219006089 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 345219006090 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 345219006091 Cytochrome P450; Region: p450; cl12078 345219006092 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 345219006093 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 345219006094 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 345219006095 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07710 345219006096 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 345219006097 PYR/PP interface [polypeptide binding]; other site 345219006098 dimer interface [polypeptide binding]; other site 345219006099 TPP binding site [chemical binding]; other site 345219006100 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 345219006101 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 345219006102 TPP-binding site [chemical binding]; other site 345219006103 dimer interface [polypeptide binding]; other site 345219006104 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 345219006105 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 345219006106 putative valine binding site [chemical binding]; other site 345219006107 dimer interface [polypeptide binding]; other site 345219006108 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 345219006109 ketol-acid reductoisomerase; Provisional; Region: PRK05479 345219006110 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 345219006111 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 345219006112 2-isopropylmalate synthase; Validated; Region: PRK00915 345219006113 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 345219006114 active site 345219006115 catalytic residues [active] 345219006116 metal binding site [ion binding]; metal-binding site 345219006117 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 345219006118 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 345219006119 tartrate dehydrogenase; Region: TTC; TIGR02089 345219006120 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 345219006121 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 345219006122 substrate binding site [chemical binding]; other site 345219006123 ligand binding site [chemical binding]; other site 345219006124 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 345219006125 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 345219006126 substrate binding site [chemical binding]; other site 345219006127 serine racemase; Region: PLN02970 345219006128 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 345219006129 tetramer interface [polypeptide binding]; other site 345219006130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219006131 catalytic residue [active] 345219006132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219006133 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 345219006134 motif II; other site 345219006135 Predicted membrane protein, putative toxin regulator [General function prediction only]; Region: PfoR; COG3641 345219006136 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 345219006137 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 345219006138 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 345219006139 ligand binding site [chemical binding]; other site 345219006140 NAD binding site [chemical binding]; other site 345219006141 dimerization interface [polypeptide binding]; other site 345219006142 catalytic site [active] 345219006143 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 345219006144 putative L-serine binding site [chemical binding]; other site 345219006145 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 345219006146 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 345219006147 catalytic residue [active] 345219006148 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 345219006149 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 345219006150 NAD binding site [chemical binding]; other site 345219006151 ligand binding site [chemical binding]; other site 345219006152 catalytic site [active] 345219006153 Cache domain; Region: Cache_1; pfam02743 345219006154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219006155 dimerization interface [polypeptide binding]; other site 345219006156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219006157 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219006158 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219006159 dimer interface [polypeptide binding]; other site 345219006160 putative CheW interface [polypeptide binding]; other site 345219006161 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 345219006162 homodimer interface [polypeptide binding]; other site 345219006163 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 345219006164 active site pocket [active] 345219006165 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 345219006166 thioester reductase domain; Region: Thioester-redct; TIGR01746 345219006167 putative NAD(P) binding site [chemical binding]; other site 345219006168 active site 345219006169 putative substrate binding site [chemical binding]; other site 345219006170 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 345219006171 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 345219006172 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 345219006173 substrate binding pocket [chemical binding]; other site 345219006174 substrate-Mg2+ binding site; other site 345219006175 aspartate-rich region 1; other site 345219006176 aspartate-rich region 2; other site 345219006177 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 345219006178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 345219006179 Histidine kinase; Region: HisKA_3; pfam07730 345219006180 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 345219006181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219006182 active site 345219006183 phosphorylation site [posttranslational modification] 345219006184 intermolecular recognition site; other site 345219006185 dimerization interface [polypeptide binding]; other site 345219006186 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 345219006187 DNA binding residues [nucleotide binding] 345219006188 dimerization interface [polypeptide binding]; other site 345219006189 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219006190 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 345219006191 Walker A/P-loop; other site 345219006192 ATP binding site [chemical binding]; other site 345219006193 Q-loop/lid; other site 345219006194 ABC transporter signature motif; other site 345219006195 Walker B; other site 345219006196 D-loop; other site 345219006197 H-loop/switch region; other site 345219006198 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 345219006199 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219006200 Walker A/P-loop; other site 345219006201 ATP binding site [chemical binding]; other site 345219006202 Q-loop/lid; other site 345219006203 ABC transporter signature motif; other site 345219006204 Walker B; other site 345219006205 D-loop; other site 345219006206 H-loop/switch region; other site 345219006207 Integral membrane protein DUF95; Region: DUF95; cl00572 345219006208 HlyD family secretion protein; Region: HlyD_2; pfam12700 345219006209 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 345219006210 HlyD family secretion protein; Region: HlyD_3; pfam13437 345219006211 putative membrane fusion protein; Region: TIGR02828 345219006212 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 345219006213 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 345219006214 Walker A/P-loop; other site 345219006215 ATP binding site [chemical binding]; other site 345219006216 Q-loop/lid; other site 345219006217 ABC transporter signature motif; other site 345219006218 Walker B; other site 345219006219 D-loop; other site 345219006220 H-loop/switch region; other site 345219006221 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 345219006222 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 345219006223 FtsX-like permease family; Region: FtsX; pfam02687 345219006224 anthranilate synthase component I; Provisional; Region: PRK13570 345219006225 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 345219006226 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 345219006227 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 345219006228 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 345219006229 glutamine binding [chemical binding]; other site 345219006230 catalytic triad [active] 345219006231 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 345219006232 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 345219006233 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 345219006234 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 345219006235 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 345219006236 active site 345219006237 ribulose/triose binding site [chemical binding]; other site 345219006238 phosphate binding site [ion binding]; other site 345219006239 substrate (anthranilate) binding pocket [chemical binding]; other site 345219006240 product (indole) binding pocket [chemical binding]; other site 345219006241 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 345219006242 active site 345219006243 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 345219006244 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 345219006245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219006246 catalytic residue [active] 345219006247 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 345219006248 substrate binding site [chemical binding]; other site 345219006249 active site 345219006250 catalytic residues [active] 345219006251 heterodimer interface [polypeptide binding]; other site 345219006252 YfhD-like protein; Region: YfhD; pfam14151 345219006253 YfhE-like protein; Region: YfhE; pfam14152 345219006254 recombination regulator RecX; Provisional; Region: recX; PRK14135 345219006255 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 345219006256 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 345219006257 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 345219006258 minor groove reading motif; other site 345219006259 helix-hairpin-helix signature motif; other site 345219006260 substrate binding pocket [chemical binding]; other site 345219006261 active site 345219006262 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 345219006263 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 345219006264 DNA binding and oxoG recognition site [nucleotide binding] 345219006265 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 345219006266 Small acid-soluble spore protein K family; Region: SspK; pfam08176 345219006267 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219006268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 345219006269 Walker A/P-loop; other site 345219006270 ATP binding site [chemical binding]; other site 345219006271 Q-loop/lid; other site 345219006272 ABC transporter signature motif; other site 345219006273 Walker B; other site 345219006274 D-loop; other site 345219006275 H-loop/switch region; other site 345219006276 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 345219006277 YfzA-like protein; Region: YfzA; pfam14118 345219006278 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 345219006279 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 345219006280 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 345219006281 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 345219006282 active site 345219006283 dimer interface [polypeptide binding]; other site 345219006284 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 345219006285 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 345219006286 active site 345219006287 FMN binding site [chemical binding]; other site 345219006288 substrate binding site [chemical binding]; other site 345219006289 3Fe-4S cluster binding site [ion binding]; other site 345219006290 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 345219006291 domain interface; other site 345219006292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 345219006293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 345219006294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 345219006295 dimerization interface [polypeptide binding]; other site 345219006296 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 345219006297 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 345219006298 putative NAD(P) binding site [chemical binding]; other site 345219006299 active site 345219006300 YgaB-like protein; Region: YgaB; pfam14182 345219006301 hypothetical protein; Provisional; Region: PRK13662 345219006302 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219006303 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219006304 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 345219006305 Walker A/P-loop; other site 345219006306 ATP binding site [chemical binding]; other site 345219006307 Q-loop/lid; other site 345219006308 ABC transporter signature motif; other site 345219006309 Walker B; other site 345219006310 D-loop; other site 345219006311 H-loop/switch region; other site 345219006312 Uncharacterized conserved protein [Function unknown]; Region: COG3589 345219006313 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 345219006314 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 345219006315 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 345219006316 putative active site [active] 345219006317 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 345219006318 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 345219006319 active site turn [active] 345219006320 phosphorylation site [posttranslational modification] 345219006321 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 345219006322 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 345219006323 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 345219006324 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 345219006325 putative active site [active] 345219006326 Predicted membrane protein [Function unknown]; Region: COG4129 345219006327 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 345219006328 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 345219006329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219006331 putative substrate translocation pore; other site 345219006332 Uncharacterized conserved protein [Function unknown]; Region: COG1284 345219006333 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219006334 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 345219006335 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 345219006336 Walker A/P-loop; other site 345219006337 ATP binding site [chemical binding]; other site 345219006338 Q-loop/lid; other site 345219006339 ABC transporter signature motif; other site 345219006340 Walker B; other site 345219006341 D-loop; other site 345219006342 H-loop/switch region; other site 345219006343 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 345219006344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219006345 dimer interface [polypeptide binding]; other site 345219006346 conserved gate region; other site 345219006347 putative PBP binding loops; other site 345219006348 ABC-ATPase subunit interface; other site 345219006349 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 345219006350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219006351 substrate binding pocket [chemical binding]; other site 345219006352 membrane-bound complex binding site; other site 345219006353 hinge residues; other site 345219006354 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 345219006355 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219006356 inhibitor-cofactor binding pocket; inhibition site 345219006357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219006358 catalytic residue [active] 345219006359 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 345219006360 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 345219006361 metal binding site 2 [ion binding]; metal-binding site 345219006362 putative DNA binding helix; other site 345219006363 metal binding site 1 [ion binding]; metal-binding site 345219006364 dimer interface [polypeptide binding]; other site 345219006365 structural Zn2+ binding site [ion binding]; other site 345219006366 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 345219006367 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 345219006368 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 345219006369 dimerization interface [polypeptide binding]; other site 345219006370 acetolactate synthase; Reviewed; Region: PRK08617 345219006371 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 345219006372 PYR/PP interface [polypeptide binding]; other site 345219006373 dimer interface [polypeptide binding]; other site 345219006374 TPP binding site [chemical binding]; other site 345219006375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 345219006376 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 345219006377 TPP-binding site [chemical binding]; other site 345219006378 dimer interface [polypeptide binding]; other site 345219006379 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 345219006380 Protein of unknown function (DUF2614); Region: DUF2614; pfam11023 345219006381 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219006382 Predicted membrane protein [Function unknown]; Region: COG2323 345219006383 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 345219006384 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 345219006385 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 345219006386 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 345219006387 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 345219006388 NAD binding site [chemical binding]; other site 345219006389 catalytic Zn binding site [ion binding]; other site 345219006390 substrate binding site [chemical binding]; other site 345219006391 structural Zn binding site [ion binding]; other site 345219006392 EamA-like transporter family; Region: EamA; pfam00892 345219006393 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 345219006394 EamA-like transporter family; Region: EamA; pfam00892 345219006395 benzoate transport; Region: 2A0115; TIGR00895 345219006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006397 putative substrate translocation pore; other site 345219006398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006399 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219006400 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219006401 MarR family; Region: MarR_2; pfam12802 345219006402 Uncharacterized conserved protein [Function unknown]; Region: COG1284 345219006403 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219006404 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 345219006405 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 345219006406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219006407 dimerization interface [polypeptide binding]; other site 345219006408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219006409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219006410 dimer interface [polypeptide binding]; other site 345219006411 phosphorylation site [posttranslational modification] 345219006412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219006413 ATP binding site [chemical binding]; other site 345219006414 Mg2+ binding site [ion binding]; other site 345219006415 G-X-G motif; other site 345219006416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219006417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219006418 active site 345219006419 phosphorylation site [posttranslational modification] 345219006420 intermolecular recognition site; other site 345219006421 dimerization interface [polypeptide binding]; other site 345219006422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219006423 DNA binding site [nucleotide binding] 345219006424 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 345219006425 active site 345219006426 catalytic triad [active] 345219006427 oxyanion hole [active] 345219006428 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219006429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219006430 Walker A/P-loop; other site 345219006431 ATP binding site [chemical binding]; other site 345219006432 Q-loop/lid; other site 345219006433 ABC transporter signature motif; other site 345219006434 Walker B; other site 345219006435 D-loop; other site 345219006436 H-loop/switch region; other site 345219006437 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 345219006438 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 345219006439 hypothetical protein; Provisional; Region: PRK06770 345219006440 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 345219006441 Predicted flavoprotein [General function prediction only]; Region: COG0431 345219006442 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 345219006443 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219006444 FeS/SAM binding site; other site 345219006445 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 345219006446 Pyruvate formate lyase 1; Region: PFL1; cd01678 345219006447 coenzyme A binding site [chemical binding]; other site 345219006448 active site 345219006449 catalytic residues [active] 345219006450 glycine loop; other site 345219006451 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 345219006452 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 345219006453 dimer interface [polypeptide binding]; other site 345219006454 active site 345219006455 metal binding site [ion binding]; metal-binding site 345219006456 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 345219006457 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 345219006458 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 345219006459 Walker A/P-loop; other site 345219006460 ATP binding site [chemical binding]; other site 345219006461 Q-loop/lid; other site 345219006462 ABC transporter signature motif; other site 345219006463 Walker B; other site 345219006464 D-loop; other site 345219006465 H-loop/switch region; other site 345219006466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 345219006467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219006468 dimer interface [polypeptide binding]; other site 345219006469 conserved gate region; other site 345219006470 putative PBP binding loops; other site 345219006471 ABC-ATPase subunit interface; other site 345219006472 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 345219006473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219006474 substrate binding pocket [chemical binding]; other site 345219006475 membrane-bound complex binding site; other site 345219006476 hinge residues; other site 345219006477 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 345219006478 Uncharacterized conserved protein [Function unknown]; Region: COG1633 345219006479 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 345219006480 dinuclear metal binding motif [ion binding]; other site 345219006481 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 345219006482 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 345219006483 DHHA2 domain; Region: DHHA2; pfam02833 345219006484 MarC family integral membrane protein; Region: MarC; pfam01914 345219006485 epoxyqueuosine reductase; Region: TIGR00276 345219006486 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 345219006487 HEAT repeats; Region: HEAT_2; pfam13646 345219006488 Putative amidase domain; Region: Amidase_6; pfam12671 345219006489 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 345219006490 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 345219006491 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 345219006492 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 345219006493 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 345219006494 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219006495 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 345219006496 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 345219006497 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 345219006498 catalytic residues [active] 345219006499 putative disulfide oxidoreductase; Provisional; Region: PRK03113 345219006500 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 345219006501 active site 345219006502 catalytic triad [active] 345219006503 oxyanion hole [active] 345219006504 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 345219006505 SpoVR like protein; Region: SpoVR; pfam04293 345219006506 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 345219006507 YhdB-like protein; Region: YhdB; pfam14148 345219006508 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 345219006509 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 345219006510 oligomer interface [polypeptide binding]; other site 345219006511 metal binding site [ion binding]; metal-binding site 345219006512 metal binding site [ion binding]; metal-binding site 345219006513 putative Cl binding site [ion binding]; other site 345219006514 aspartate ring; other site 345219006515 basic sphincter; other site 345219006516 hydrophobic gate; other site 345219006517 periplasmic entrance; other site 345219006518 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 345219006519 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 345219006520 catalytic triad [active] 345219006521 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 345219006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219006523 dimer interface [polypeptide binding]; other site 345219006524 conserved gate region; other site 345219006525 putative PBP binding loops; other site 345219006526 ABC-ATPase subunit interface; other site 345219006527 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 345219006528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219006529 dimer interface [polypeptide binding]; other site 345219006530 conserved gate region; other site 345219006531 putative PBP binding loops; other site 345219006532 ABC-ATPase subunit interface; other site 345219006533 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 345219006534 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219006535 Walker A/P-loop; other site 345219006536 ATP binding site [chemical binding]; other site 345219006537 Q-loop/lid; other site 345219006538 ABC transporter signature motif; other site 345219006539 Walker B; other site 345219006540 D-loop; other site 345219006541 H-loop/switch region; other site 345219006542 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 345219006543 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 345219006544 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 345219006545 peptide binding site [polypeptide binding]; other site 345219006546 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 345219006547 NlpC/P60 family; Region: NLPC_P60; pfam00877 345219006548 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 345219006549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219006550 Walker A/P-loop; other site 345219006551 ATP binding site [chemical binding]; other site 345219006552 Q-loop/lid; other site 345219006553 ABC transporter signature motif; other site 345219006554 Walker B; other site 345219006555 D-loop; other site 345219006556 H-loop/switch region; other site 345219006557 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 345219006558 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 345219006559 Ligand Binding Site [chemical binding]; other site 345219006560 Transglycosylase; Region: Transgly; pfam00912 345219006561 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 345219006562 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 345219006563 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219006564 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219006565 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 345219006566 heme-binding site [chemical binding]; other site 345219006567 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219006568 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219006569 dimer interface [polypeptide binding]; other site 345219006570 putative CheW interface [polypeptide binding]; other site 345219006571 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 345219006572 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 345219006573 catalytic loop [active] 345219006574 iron binding site [ion binding]; other site 345219006575 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 345219006576 4Fe-4S binding domain; Region: Fer4; pfam00037 345219006577 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 345219006578 [4Fe-4S] binding site [ion binding]; other site 345219006579 molybdopterin cofactor binding site; other site 345219006580 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 345219006581 molybdopterin cofactor binding site; other site 345219006582 Uncharacterized conserved protein [Function unknown]; Region: COG2427 345219006583 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 345219006584 metal-binding site [ion binding] 345219006585 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 345219006586 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 345219006587 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 345219006588 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 345219006589 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 345219006590 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 345219006591 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 345219006592 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 345219006593 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 345219006594 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 345219006595 Phosphoglycerate kinase; Region: PGK; pfam00162 345219006596 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 345219006597 substrate binding site [chemical binding]; other site 345219006598 hinge regions; other site 345219006599 ADP binding site [chemical binding]; other site 345219006600 catalytic site [active] 345219006601 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 345219006602 triosephosphate isomerase; Provisional; Region: PRK14565 345219006603 substrate binding site [chemical binding]; other site 345219006604 dimer interface [polypeptide binding]; other site 345219006605 catalytic triad [active] 345219006606 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 345219006607 phosphoglyceromutase; Provisional; Region: PRK05434 345219006608 enolase; Provisional; Region: eno; PRK00077 345219006609 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 345219006610 dimer interface [polypeptide binding]; other site 345219006611 metal binding site [ion binding]; metal-binding site 345219006612 substrate binding pocket [chemical binding]; other site 345219006613 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 345219006614 Esterase/lipase [General function prediction only]; Region: COG1647 345219006615 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 345219006616 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 345219006617 ribonuclease R; Region: RNase_R; TIGR02063 345219006618 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 345219006619 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 345219006620 RNB domain; Region: RNB; pfam00773 345219006621 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 345219006622 RNA binding site [nucleotide binding]; other site 345219006623 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 345219006624 SmpB-tmRNA interface; other site 345219006625 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219006626 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 345219006627 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 345219006628 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 345219006629 active site 345219006630 catalytic triad [active] 345219006631 calcium binding site [ion binding]; other site 345219006632 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 345219006633 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219006634 Transcriptional regulator [Transcription]; Region: IclR; COG1414 345219006635 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 345219006636 Bacterial transcriptional regulator; Region: IclR; pfam01614 345219006637 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 345219006638 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 345219006639 active site 345219006640 intersubunit interface [polypeptide binding]; other site 345219006641 catalytic residue [active] 345219006642 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 345219006643 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 345219006644 substrate binding site [chemical binding]; other site 345219006645 ATP binding site [chemical binding]; other site 345219006646 altronate oxidoreductase; Provisional; Region: PRK03643 345219006647 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 345219006648 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 345219006649 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 345219006650 galactarate dehydratase; Region: galactar-dH20; TIGR03248 345219006651 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 345219006652 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 345219006653 Glucuronate isomerase; Region: UxaC; pfam02614 345219006654 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 345219006655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006656 putative substrate translocation pore; other site 345219006657 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 345219006658 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 345219006659 NADP binding site [chemical binding]; other site 345219006660 homodimer interface [polypeptide binding]; other site 345219006661 active site 345219006662 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 345219006663 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 345219006664 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 345219006665 substrate binding site [chemical binding]; other site 345219006666 ATP binding site [chemical binding]; other site 345219006667 biotin synthase; Validated; Region: PRK06256 345219006668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219006669 FeS/SAM binding site; other site 345219006670 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 345219006671 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 345219006672 active site 345219006673 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 345219006674 conserved hypothetical integral membrane protein; Region: TIGR03766 345219006675 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 345219006676 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 345219006677 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 345219006678 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 345219006679 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219006680 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219006681 DNA binding residues [nucleotide binding] 345219006682 Putative zinc-finger; Region: zf-HC2; pfam13490 345219006683 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 345219006684 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 345219006685 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 345219006686 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 345219006687 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 345219006688 NodB motif; other site 345219006689 putative active site [active] 345219006690 putative catalytic site [active] 345219006691 putative Zn binding site [ion binding]; other site 345219006692 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 345219006693 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 345219006694 active site 345219006695 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 345219006696 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 345219006697 tetramer interface [polypeptide binding]; other site 345219006698 heme binding pocket [chemical binding]; other site 345219006699 NADPH binding site [chemical binding]; other site 345219006700 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 345219006701 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 345219006702 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 345219006703 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 345219006704 putative active site [active] 345219006705 putative catalytic site [active] 345219006706 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 345219006707 PLD-like domain; Region: PLDc_2; pfam13091 345219006708 putative active site [active] 345219006709 putative catalytic site [active] 345219006710 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 345219006711 catalytic residues [active] 345219006712 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 345219006713 Coat F domain; Region: Coat_F; pfam07875 345219006714 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219006715 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219006716 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219006717 YuzL-like protein; Region: YuzL; pfam14115 345219006718 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 345219006719 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 345219006720 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 345219006721 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 345219006722 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 345219006723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 345219006724 substrate binding site [chemical binding]; other site 345219006725 oxyanion hole (OAH) forming residues; other site 345219006726 trimer interface [polypeptide binding]; other site 345219006727 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 345219006728 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 345219006729 dimer interface [polypeptide binding]; other site 345219006730 active site 345219006731 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 345219006732 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 345219006733 active site 345219006734 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 345219006735 ArsC family; Region: ArsC; pfam03960 345219006736 putative ArsC-like catalytic residues; other site 345219006737 putative TRX-like catalytic residues [active] 345219006738 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 345219006739 lipoyl attachment site [posttranslational modification]; other site 345219006740 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 345219006741 catalytic residues [active] 345219006742 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 345219006743 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 345219006744 Walker A/P-loop; other site 345219006745 ATP binding site [chemical binding]; other site 345219006746 Q-loop/lid; other site 345219006747 ABC transporter signature motif; other site 345219006748 Walker B; other site 345219006749 D-loop; other site 345219006750 H-loop/switch region; other site 345219006751 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 345219006752 FeS assembly protein SufD; Region: sufD; TIGR01981 345219006753 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 345219006754 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 345219006755 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 345219006756 catalytic residue [active] 345219006757 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 345219006758 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 345219006759 trimerization site [polypeptide binding]; other site 345219006760 active site 345219006761 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 345219006762 FeS assembly protein SufB; Region: sufB; TIGR01980 345219006763 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 345219006764 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 345219006765 active site 345219006766 metal binding site [ion binding]; metal-binding site 345219006767 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 345219006768 Uncharacterized conserved protein [Function unknown]; Region: COG3377 345219006769 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 345219006770 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 345219006771 Peptidase family M23; Region: Peptidase_M23; pfam01551 345219006772 lipoyl synthase; Provisional; Region: PRK05481 345219006773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219006774 FeS/SAM binding site; other site 345219006775 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 345219006776 Uncharacterized conserved protein [Function unknown]; Region: COG2445 345219006777 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 345219006778 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219006779 active site 345219006780 motif I; other site 345219006781 motif II; other site 345219006782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219006783 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 345219006784 tetramer interfaces [polypeptide binding]; other site 345219006785 binuclear metal-binding site [ion binding]; other site 345219006786 spore coat protein YutH; Region: spore_yutH; TIGR02905 345219006787 NifU-like domain; Region: NifU; pfam01106 345219006788 Protein of unknown function (DUF1462); Region: DUF1462; pfam07315 345219006789 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 345219006790 Predicted membrane protein [Function unknown]; Region: COG4640 345219006791 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 345219006792 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219006793 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219006794 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 345219006795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219006796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219006797 Putative membrane protein; Region: YuiB; pfam14068 345219006798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 345219006799 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 345219006800 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 345219006801 interface (dimer of trimers) [polypeptide binding]; other site 345219006802 Substrate-binding/catalytic site; other site 345219006803 Zn-binding sites [ion binding]; other site 345219006804 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 345219006805 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 345219006806 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 345219006807 Spore germination protein; Region: Spore_permease; pfam03845 345219006808 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 345219006809 CoenzymeA binding site [chemical binding]; other site 345219006810 subunit interaction site [polypeptide binding]; other site 345219006811 PHB binding site; other site 345219006812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219006814 putative substrate translocation pore; other site 345219006815 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 345219006816 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 345219006817 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 345219006818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 345219006819 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 345219006820 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 345219006821 hydroxyglutarate oxidase; Provisional; Region: PRK11728 345219006822 Kinase associated protein B; Region: KapB; pfam08810 345219006823 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 345219006824 active site 345219006825 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 345219006826 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 345219006827 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219006828 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219006829 active site 345219006830 catalytic tetrad [active] 345219006831 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219006832 active site 345219006833 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219006834 catalytic tetrad [active] 345219006835 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 345219006836 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 345219006837 active site 345219006838 FMN binding site [chemical binding]; other site 345219006839 substrate binding site [chemical binding]; other site 345219006840 homotetramer interface [polypeptide binding]; other site 345219006841 catalytic residue [active] 345219006842 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219006843 non-specific DNA binding site [nucleotide binding]; other site 345219006844 salt bridge; other site 345219006845 sequence-specific DNA binding site [nucleotide binding]; other site 345219006846 general stress protein 13; Validated; Region: PRK08059 345219006847 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 345219006848 RNA binding site [nucleotide binding]; other site 345219006849 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 345219006850 Uncharacterized conserved protein [Function unknown]; Region: COG2155 345219006851 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 345219006852 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 345219006853 active site 345219006854 dimer interface [polypeptide binding]; other site 345219006855 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 345219006856 dimer interface [polypeptide binding]; other site 345219006857 active site 345219006858 Ion channel; Region: Ion_trans_2; pfam07885 345219006859 TrkA-N domain; Region: TrkA_N; pfam02254 345219006860 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 345219006861 ornithine cyclodeaminase; Validated; Region: PRK08618 345219006862 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 345219006863 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 345219006864 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 345219006865 NAD(P) binding site [chemical binding]; other site 345219006866 catalytic residues [active] 345219006867 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 345219006868 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 345219006869 hydroxyglutarate oxidase; Provisional; Region: PRK11728 345219006870 Divergent PAP2 family; Region: DUF212; pfam02681 345219006871 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 345219006872 classical (c) SDRs; Region: SDR_c; cd05233 345219006873 NAD(P) binding site [chemical binding]; other site 345219006874 active site 345219006875 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 345219006876 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 345219006877 Ligand binding site; other site 345219006878 Putative Catalytic site; other site 345219006879 DXD motif; other site 345219006880 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 345219006881 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 345219006882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219006883 dimerization interface [polypeptide binding]; other site 345219006884 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219006885 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219006886 dimer interface [polypeptide binding]; other site 345219006887 putative CheW interface [polypeptide binding]; other site 345219006888 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219006889 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 345219006890 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219006891 DNA-binding site [nucleotide binding]; DNA binding site 345219006892 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219006893 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 345219006894 putative dimerization interface [polypeptide binding]; other site 345219006895 putative ligand binding site [chemical binding]; other site 345219006896 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 345219006897 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 345219006898 putative N- and C-terminal domain interface [polypeptide binding]; other site 345219006899 putative active site [active] 345219006900 MgATP binding site [chemical binding]; other site 345219006901 catalytic site [active] 345219006902 metal binding site [ion binding]; metal-binding site 345219006903 putative carbohydrate binding site [chemical binding]; other site 345219006904 L-arabinose isomerase; Provisional; Region: PRK02929 345219006905 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 345219006906 hexamer (dimer of trimers) interface [polypeptide binding]; other site 345219006907 trimer interface [polypeptide binding]; other site 345219006908 substrate binding site [chemical binding]; other site 345219006909 Mn binding site [ion binding]; other site 345219006910 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 345219006911 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 345219006912 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 345219006913 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 345219006914 TM-ABC transporter signature motif; other site 345219006915 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 345219006916 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 345219006917 Walker A/P-loop; other site 345219006918 ATP binding site [chemical binding]; other site 345219006919 Q-loop/lid; other site 345219006920 ABC transporter signature motif; other site 345219006921 Walker B; other site 345219006922 D-loop; other site 345219006923 H-loop/switch region; other site 345219006924 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 345219006925 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 345219006926 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 345219006927 putative ligand binding site [chemical binding]; other site 345219006928 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 345219006929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219006930 DNA-binding site [nucleotide binding]; DNA binding site 345219006931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 345219006932 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 345219006933 putative dimerization interface [polypeptide binding]; other site 345219006934 putative ligand binding site [chemical binding]; other site 345219006935 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 345219006936 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 345219006937 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219006938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 345219006939 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 345219006940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 345219006942 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 345219006943 L-arabinose isomerase; Provisional; Region: PRK02929 345219006944 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 345219006945 hexamer (dimer of trimers) interface [polypeptide binding]; other site 345219006946 trimer interface [polypeptide binding]; other site 345219006947 substrate binding site [chemical binding]; other site 345219006948 Mn binding site [ion binding]; other site 345219006949 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 345219006950 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 345219006951 intersubunit interface [polypeptide binding]; other site 345219006952 active site 345219006953 Zn2+ binding site [ion binding]; other site 345219006954 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 345219006955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006956 putative substrate translocation pore; other site 345219006957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219006958 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 345219006959 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 345219006960 putative N- and C-terminal domain interface [polypeptide binding]; other site 345219006961 putative active site [active] 345219006962 MgATP binding site [chemical binding]; other site 345219006963 catalytic site [active] 345219006964 metal binding site [ion binding]; metal-binding site 345219006965 putative carbohydrate binding site [chemical binding]; other site 345219006966 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 345219006967 HPr interaction site; other site 345219006968 glycerol kinase (GK) interaction site [polypeptide binding]; other site 345219006969 active site 345219006970 phosphorylation site [posttranslational modification] 345219006971 Staphylococcal nuclease homologues; Region: SNc; smart00318 345219006972 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 345219006973 Catalytic site; other site 345219006974 Excalibur calcium-binding domain; Region: Excalibur; smart00894 345219006975 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 345219006976 putative homodimer interface [polypeptide binding]; other site 345219006977 putative homotetramer interface [polypeptide binding]; other site 345219006978 putative metal binding site [ion binding]; other site 345219006979 putative homodimer-homodimer interface [polypeptide binding]; other site 345219006980 putative allosteric switch controlling residues; other site 345219006981 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 345219006982 active site residue [active] 345219006983 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 345219006984 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 345219006985 Cl- selectivity filter; other site 345219006986 Cl- binding residues [ion binding]; other site 345219006987 pore gating glutamate residue; other site 345219006988 dimer interface [polypeptide binding]; other site 345219006989 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 345219006990 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 345219006991 NodB motif; other site 345219006992 active site 345219006993 catalytic site [active] 345219006994 Zn binding site [ion binding]; other site 345219006995 Putative cell-wall binding lipoprotein; Region: YkyA; pfam10368 345219006996 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 345219006997 classical (c) SDRs; Region: SDR_c; cd05233 345219006998 NAD(P) binding site [chemical binding]; other site 345219006999 active site 345219007000 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 345219007001 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 345219007002 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219007003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219007004 active site 345219007005 phosphorylation site [posttranslational modification] 345219007006 intermolecular recognition site; other site 345219007007 dimerization interface [polypeptide binding]; other site 345219007008 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219007009 DNA binding site [nucleotide binding] 345219007010 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219007011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219007012 dimerization interface [polypeptide binding]; other site 345219007013 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219007014 dimer interface [polypeptide binding]; other site 345219007015 phosphorylation site [posttranslational modification] 345219007016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219007017 ATP binding site [chemical binding]; other site 345219007018 Mg2+ binding site [ion binding]; other site 345219007019 G-X-G motif; other site 345219007020 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 345219007021 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 345219007022 dimerization interface [polypeptide binding]; other site 345219007023 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 345219007024 dimerization interface [polypeptide binding]; other site 345219007025 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 345219007026 Na binding site [ion binding]; other site 345219007027 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 345219007028 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 345219007029 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 345219007030 metal binding site [ion binding]; metal-binding site 345219007031 dimer interface [polypeptide binding]; other site 345219007032 Uncharacterized conserved protein [Function unknown]; Region: COG2128 345219007033 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 345219007034 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219007035 putative DNA binding site [nucleotide binding]; other site 345219007036 putative Zn2+ binding site [ion binding]; other site 345219007037 AsnC family; Region: AsnC_trans_reg; pfam01037 345219007038 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 345219007039 putative homodimer interface [polypeptide binding]; other site 345219007040 putative homotetramer interface [polypeptide binding]; other site 345219007041 allosteric switch controlling residues; other site 345219007042 putative metal binding site [ion binding]; other site 345219007043 putative homodimer-homodimer interface [polypeptide binding]; other site 345219007044 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 345219007045 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 345219007046 metal-binding site [ion binding] 345219007047 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 345219007048 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 345219007049 metal-binding site [ion binding] 345219007050 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 345219007051 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 345219007052 metal-binding site [ion binding] 345219007053 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 345219007054 Soluble P-type ATPase [General function prediction only]; Region: COG4087 345219007055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219007056 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219007057 putative substrate translocation pore; other site 345219007058 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 345219007059 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 345219007060 MgtC family; Region: MgtC; pfam02308 345219007061 EamA-like transporter family; Region: EamA; pfam00892 345219007062 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 345219007063 EamA-like transporter family; Region: EamA; pfam00892 345219007064 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 345219007065 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 345219007066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219007067 salt bridge; other site 345219007068 non-specific DNA binding site [nucleotide binding]; other site 345219007069 sequence-specific DNA binding site [nucleotide binding]; other site 345219007070 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 345219007071 UbiA prenyltransferase family; Region: UbiA; pfam01040 345219007072 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 345219007073 chorismate binding enzyme; Region: Chorismate_bind; cl10555 345219007074 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 345219007075 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 345219007076 dimer interface [polypeptide binding]; other site 345219007077 tetramer interface [polypeptide binding]; other site 345219007078 PYR/PP interface [polypeptide binding]; other site 345219007079 TPP binding site [chemical binding]; other site 345219007080 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 345219007081 TPP-binding site; other site 345219007082 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 345219007083 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 345219007084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 345219007085 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 345219007086 substrate binding site [chemical binding]; other site 345219007087 oxyanion hole (OAH) forming residues; other site 345219007088 trimer interface [polypeptide binding]; other site 345219007089 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 345219007090 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 345219007091 acyl-activating enzyme (AAE) consensus motif; other site 345219007092 putative AMP binding site [chemical binding]; other site 345219007093 putative active site [active] 345219007094 putative CoA binding site [chemical binding]; other site 345219007095 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 345219007096 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 345219007097 active site 345219007098 octamer interface [polypeptide binding]; other site 345219007099 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 345219007100 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 345219007101 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 345219007102 intersubunit interface [polypeptide binding]; other site 345219007103 Protein of unknown function (DUF4021); Region: DUF4021; pfam13213 345219007104 hypothetical protein; Validated; Region: PRK00041 345219007105 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 345219007106 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 345219007107 dimerization interface [polypeptide binding]; other site 345219007108 DPS ferroxidase diiron center [ion binding]; other site 345219007109 ion pore; other site 345219007110 nucleoside triphosphatase YtkD; Region: nudix_YtkD; TIGR02705 345219007111 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_8; cd04665 345219007112 nudix motif; other site 345219007113 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 345219007114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219007115 dimer interface [polypeptide binding]; other site 345219007116 conserved gate region; other site 345219007117 putative PBP binding loops; other site 345219007118 ABC-ATPase subunit interface; other site 345219007119 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 345219007120 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 345219007121 Walker A/P-loop; other site 345219007122 ATP binding site [chemical binding]; other site 345219007123 Q-loop/lid; other site 345219007124 ABC transporter signature motif; other site 345219007125 Walker B; other site 345219007126 D-loop; other site 345219007127 H-loop/switch region; other site 345219007128 NMT1-like family; Region: NMT1_2; pfam13379 345219007129 NMT1/THI5 like; Region: NMT1; pfam09084 345219007130 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 345219007131 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 345219007132 N- and C-terminal domain interface [polypeptide binding]; other site 345219007133 active site 345219007134 catalytic site [active] 345219007135 metal binding site [ion binding]; metal-binding site 345219007136 carbohydrate binding site [chemical binding]; other site 345219007137 ATP binding site [chemical binding]; other site 345219007138 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 345219007139 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 345219007140 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 345219007141 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 345219007142 Protein of unknown function (DUF2584); Region: DUF2584; pfam10763 345219007143 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 345219007144 nudix motif; other site 345219007145 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 345219007146 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 345219007147 active site 345219007148 substrate-binding site [chemical binding]; other site 345219007149 metal-binding site [ion binding] 345219007150 ATP binding site [chemical binding]; other site 345219007151 S-adenosylmethionine synthetase; Validated; Region: PRK05250 345219007152 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 345219007153 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 345219007154 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 345219007155 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 345219007156 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 345219007157 active site 345219007158 dimer interface [polypeptide binding]; other site 345219007159 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 345219007160 Ligand Binding Site [chemical binding]; other site 345219007161 Molecular Tunnel; other site 345219007162 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 345219007163 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 345219007164 trimer interface [polypeptide binding]; other site 345219007165 putative metal binding site [ion binding]; other site 345219007166 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 345219007167 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 345219007168 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 345219007169 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 345219007170 Methyltransferase domain; Region: Methyltransf_31; pfam13847 345219007171 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 345219007172 Protein of unknown function (DUF2524); Region: DUF2524; pfam10732 345219007173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219007174 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 345219007175 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 345219007176 HIGH motif; other site 345219007177 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 345219007178 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 345219007179 active site 345219007180 KMSKS motif; other site 345219007181 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 345219007182 tRNA binding surface [nucleotide binding]; other site 345219007183 Protein of unknown function (DUF2758); Region: DUF2758; pfam10957 345219007184 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 345219007185 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 345219007186 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 345219007187 dipeptidase PepV; Reviewed; Region: PRK07318 345219007188 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 345219007189 active site 345219007190 metal binding site [ion binding]; metal-binding site 345219007191 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 345219007192 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 345219007193 homodimer interface [polypeptide binding]; other site 345219007194 substrate-cofactor binding pocket; other site 345219007195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219007196 catalytic residue [active] 345219007197 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 345219007198 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 345219007199 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 345219007200 Phosphotransferase enzyme family; Region: APH; pfam01636 345219007201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 345219007202 active site 345219007203 substrate binding site [chemical binding]; other site 345219007204 ATP binding site [chemical binding]; other site 345219007205 YtzH-like protein; Region: YtzH; pfam14165 345219007206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219007207 S-adenosylmethionine binding site [chemical binding]; other site 345219007208 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 345219007209 Predicted small secreted protein [Function unknown]; Region: COG5584 345219007210 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 345219007211 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 345219007212 oligomer interface [polypeptide binding]; other site 345219007213 active site 345219007214 metal binding site [ion binding]; metal-binding site 345219007215 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 345219007216 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219007217 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 345219007218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219007219 dimerization interface [polypeptide binding]; other site 345219007220 GAF domain; Region: GAF; cl17456 345219007221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219007222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219007223 dimer interface [polypeptide binding]; other site 345219007224 phosphorylation site [posttranslational modification] 345219007225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219007226 ATP binding site [chemical binding]; other site 345219007227 Mg2+ binding site [ion binding]; other site 345219007228 G-X-G motif; other site 345219007229 Response regulator receiver domain; Region: Response_reg; pfam00072 345219007230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219007231 active site 345219007232 phosphorylation site [posttranslational modification] 345219007233 intermolecular recognition site; other site 345219007234 dimerization interface [polypeptide binding]; other site 345219007235 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 345219007236 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 345219007237 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 345219007238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219007239 active site 345219007240 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 345219007241 phosphorylation site [posttranslational modification] 345219007242 intermolecular recognition site; other site 345219007243 dimerization interface [polypeptide binding]; other site 345219007244 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 345219007245 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 345219007246 catalytic residues [active] 345219007247 Protein of unknown function (DUF1444); Region: DUF1444; pfam07285 345219007248 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 345219007249 putative tRNA-binding site [nucleotide binding]; other site 345219007250 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 345219007251 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 345219007252 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 345219007253 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 345219007254 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 345219007255 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 345219007256 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 345219007257 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 345219007258 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 345219007259 YtxH-like protein; Region: YtxH; pfam12732 345219007260 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 345219007261 Chorismate mutase type II; Region: CM_2; cl00693 345219007262 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 345219007263 catabolite control protein A; Region: ccpA; TIGR01481 345219007264 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 345219007265 DNA binding site [nucleotide binding] 345219007266 domain linker motif; other site 345219007267 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 345219007268 dimerization interface [polypeptide binding]; other site 345219007269 effector binding site; other site 345219007270 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 345219007271 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 345219007272 active site 345219007273 Zn binding site [ion binding]; other site 345219007274 FOG: CBS domain [General function prediction only]; Region: COG0517 345219007275 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 345219007276 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 345219007277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219007278 Coenzyme A binding pocket [chemical binding]; other site 345219007279 acetyl-CoA synthetase; Provisional; Region: PRK04319 345219007280 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 345219007281 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 345219007282 active site 345219007283 acyl-activating enzyme (AAE) consensus motif; other site 345219007284 putative CoA binding site [chemical binding]; other site 345219007285 AMP binding site [chemical binding]; other site 345219007286 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 345219007287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 345219007288 substrate binding pocket [chemical binding]; other site 345219007289 membrane-bound complex binding site; other site 345219007290 hinge residues; other site 345219007291 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 345219007292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219007293 dimer interface [polypeptide binding]; other site 345219007294 conserved gate region; other site 345219007295 putative PBP binding loops; other site 345219007296 ABC-ATPase subunit interface; other site 345219007297 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219007298 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 345219007299 Walker A/P-loop; other site 345219007300 ATP binding site [chemical binding]; other site 345219007301 Q-loop/lid; other site 345219007302 ABC transporter signature motif; other site 345219007303 Walker B; other site 345219007304 D-loop; other site 345219007305 H-loop/switch region; other site 345219007306 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 345219007307 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219007308 FeS/SAM binding site; other site 345219007309 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 345219007310 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 345219007311 MPT binding site; other site 345219007312 trimer interface [polypeptide binding]; other site 345219007313 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 345219007314 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 345219007315 GTP binding site; other site 345219007316 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 345219007317 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 345219007318 dimer interface [polypeptide binding]; other site 345219007319 putative functional site; other site 345219007320 putative MPT binding site; other site 345219007321 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 345219007322 Walker A motif; other site 345219007323 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 345219007324 MoaE homodimer interface [polypeptide binding]; other site 345219007325 MoaD interaction [polypeptide binding]; other site 345219007326 active site residues [active] 345219007327 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 345219007328 MoaE interaction surface [polypeptide binding]; other site 345219007329 MoeB interaction surface [polypeptide binding]; other site 345219007330 thiocarboxylated glycine; other site 345219007331 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 345219007332 trimer interface [polypeptide binding]; other site 345219007333 dimer interface [polypeptide binding]; other site 345219007334 putative active site [active] 345219007335 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 345219007336 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 345219007337 ATP binding site [chemical binding]; other site 345219007338 substrate interface [chemical binding]; other site 345219007339 Uncharacterized conserved protein [Function unknown]; Region: COG2427 345219007340 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 345219007341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 345219007342 catalytic loop [active] 345219007343 iron binding site [ion binding]; other site 345219007344 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 345219007345 4Fe-4S binding domain; Region: Fer4; pfam00037 345219007346 4Fe-4S binding domain; Region: Fer4; pfam00037 345219007347 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 345219007348 [4Fe-4S] binding site [ion binding]; other site 345219007349 molybdopterin cofactor binding site; other site 345219007350 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 345219007351 molybdopterin cofactor binding site; other site 345219007352 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 345219007353 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 345219007354 catalytic core domain of tyrosinyl-tRNA and tryptophanyl-tRNA synthetase; Region: Tyr_Trp_RS_core; cd00395 345219007355 active site 345219007356 HIGH motif; other site 345219007357 dimer interface [polypeptide binding]; other site 345219007358 KMSKS motif; other site 345219007359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219007360 RNA binding surface [nucleotide binding]; other site 345219007361 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219007362 PAS domain; Region: PAS_9; pfam13426 345219007363 putative active site [active] 345219007364 heme pocket [chemical binding]; other site 345219007365 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 345219007366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219007367 Walker A motif; other site 345219007368 ATP binding site [chemical binding]; other site 345219007369 Walker B motif; other site 345219007370 arginine finger; other site 345219007371 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219007372 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 345219007373 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 345219007374 Glutamate binding site [chemical binding]; other site 345219007375 homodimer interface [polypeptide binding]; other site 345219007376 NAD binding site [chemical binding]; other site 345219007377 catalytic residues [active] 345219007378 Proline dehydrogenase; Region: Pro_dh; cl03282 345219007379 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219007380 non-specific DNA binding site [nucleotide binding]; other site 345219007381 salt bridge; other site 345219007382 sequence-specific DNA binding site [nucleotide binding]; other site 345219007383 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 345219007384 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 345219007385 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219007386 RNA binding surface [nucleotide binding]; other site 345219007387 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 345219007388 GAF domain; Region: GAF_2; pfam13185 345219007389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 345219007390 GAF domain; Region: GAF_3; pfam13492 345219007391 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 345219007392 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 345219007393 metal binding site [ion binding]; metal-binding site 345219007394 active site 345219007395 I-site; other site 345219007396 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 345219007397 GAF domain; Region: GAF_2; pfam13185 345219007398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219007399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219007400 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 345219007401 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 345219007402 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 345219007403 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 345219007404 catalytic residue [active] 345219007405 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 345219007406 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 345219007407 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 345219007408 Ligand Binding Site [chemical binding]; other site 345219007409 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 345219007410 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 345219007411 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 345219007412 active site 345219007413 acyl-activating enzyme (AAE) consensus motif; other site 345219007414 putative CoA binding site [chemical binding]; other site 345219007415 AMP binding site [chemical binding]; other site 345219007416 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 345219007417 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 345219007418 tandem repeat interface [polypeptide binding]; other site 345219007419 oligomer interface [polypeptide binding]; other site 345219007420 active site residues [active] 345219007421 RDD family; Region: RDD; pfam06271 345219007422 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 345219007423 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 345219007424 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 345219007425 dimer interface [polypeptide binding]; other site 345219007426 catalytic triad [active] 345219007427 peroxidatic and resolving cysteines [active] 345219007428 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 345219007429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219007430 S-adenosylmethionine binding site [chemical binding]; other site 345219007431 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 345219007432 propionate/acetate kinase; Provisional; Region: PRK12379 345219007433 EcsC protein family; Region: EcsC; pfam12787 345219007434 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 345219007435 Ligand Binding Site [chemical binding]; other site 345219007436 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 345219007437 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 345219007438 hexamer interface [polypeptide binding]; other site 345219007439 ligand binding site [chemical binding]; other site 345219007440 putative active site [active] 345219007441 NAD(P) binding site [chemical binding]; other site 345219007442 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 345219007443 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 345219007444 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 345219007445 active site 345219007446 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 345219007447 metal-dependent hydrolase; Provisional; Region: PRK00685 345219007448 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 345219007449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 345219007450 DNA-binding site [nucleotide binding]; DNA binding site 345219007451 DRTGG domain; Region: DRTGG; pfam07085 345219007452 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 345219007453 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 345219007454 active site 2 [active] 345219007455 active site 1 [active] 345219007456 YtpI-like protein; Region: YtpI; pfam14007 345219007457 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 345219007458 DHH family; Region: DHH; pfam01368 345219007459 DHHA1 domain; Region: DHHA1; pfam02272 345219007460 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 345219007461 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 345219007462 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 345219007463 active site 345219007464 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 345219007465 generic binding surface II; other site 345219007466 generic binding surface I; other site 345219007467 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 345219007468 Malic enzyme, N-terminal domain; Region: malic; pfam00390 345219007469 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 345219007470 putative NAD(P) binding site [chemical binding]; other site 345219007471 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 345219007472 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 345219007473 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 345219007474 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 345219007475 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 345219007476 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 345219007477 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 345219007478 active site 345219007479 ADP/pyrophosphate binding site [chemical binding]; other site 345219007480 dimerization interface [polypeptide binding]; other site 345219007481 allosteric effector site; other site 345219007482 fructose-1,6-bisphosphate binding site; other site 345219007483 pyruvate kinase; Provisional; Region: PRK06354 345219007484 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 345219007485 domain interfaces; other site 345219007486 active site 345219007487 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 345219007488 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 345219007489 Domain of unknown function DUF20; Region: UPF0118; pfam01594 345219007490 Protein of unknown function (DUF441); Region: DUF441; pfam04284 345219007491 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 345219007492 dimer interface [polypeptide binding]; other site 345219007493 Citrate synthase; Region: Citrate_synt; pfam00285 345219007494 active site 345219007495 citrylCoA binding site [chemical binding]; other site 345219007496 oxalacetate/citrate binding site [chemical binding]; other site 345219007497 coenzyme A binding site [chemical binding]; other site 345219007498 catalytic triad [active] 345219007499 isocitrate dehydrogenase; Reviewed; Region: PRK07006 345219007500 isocitrate dehydrogenase; Validated; Region: PRK07362 345219007501 malate dehydrogenase; Reviewed; Region: PRK06223 345219007502 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 345219007503 NAD(P) binding site [chemical binding]; other site 345219007504 dimer interface [polypeptide binding]; other site 345219007505 tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219007506 substrate binding site [chemical binding]; other site 345219007507 DNA polymerase I; Provisional; Region: PRK05755 345219007508 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 345219007509 active site 345219007510 metal binding site 1 [ion binding]; metal-binding site 345219007511 putative 5' ssDNA interaction site; other site 345219007512 metal binding site 3; metal-binding site 345219007513 metal binding site 2 [ion binding]; metal-binding site 345219007514 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 345219007515 putative DNA binding site [nucleotide binding]; other site 345219007516 putative metal binding site [ion binding]; other site 345219007517 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 345219007518 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 345219007519 active site 345219007520 DNA binding site [nucleotide binding] 345219007521 catalytic site [active] 345219007522 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 345219007523 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 345219007524 DNA binding site [nucleotide binding] 345219007525 catalytic residue [active] 345219007526 H2TH interface [polypeptide binding]; other site 345219007527 putative catalytic residues [active] 345219007528 turnover-facilitating residue; other site 345219007529 intercalation triad [nucleotide binding]; other site 345219007530 8OG recognition residue [nucleotide binding]; other site 345219007531 putative reading head residues; other site 345219007532 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 345219007533 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 345219007534 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 345219007535 Domain of unknown function DUF; Region: DUF204; pfam02659 345219007536 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 345219007537 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 345219007538 CoA-binding site [chemical binding]; other site 345219007539 ATP-binding [chemical binding]; other site 345219007540 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 345219007541 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 345219007542 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 345219007543 Uncharacterized conserved protein [Function unknown]; Region: COG5476 345219007544 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 345219007545 MlrC C-terminus; Region: MlrC_C; pfam07171 345219007546 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 345219007547 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 345219007548 metal binding site [ion binding]; metal-binding site 345219007549 putative dimer interface [polypeptide binding]; other site 345219007550 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 345219007551 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_16; cd08502 345219007552 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 345219007553 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219007554 dimer interface [polypeptide binding]; other site 345219007555 conserved gate region; other site 345219007556 putative PBP binding loops; other site 345219007557 ABC-ATPase subunit interface; other site 345219007558 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 345219007559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 345219007560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219007561 dimer interface [polypeptide binding]; other site 345219007562 conserved gate region; other site 345219007563 putative PBP binding loops; other site 345219007564 ABC-ATPase subunit interface; other site 345219007565 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 345219007566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219007567 Walker A/P-loop; other site 345219007568 ATP binding site [chemical binding]; other site 345219007569 Q-loop/lid; other site 345219007570 ABC transporter signature motif; other site 345219007571 Walker B; other site 345219007572 D-loop; other site 345219007573 H-loop/switch region; other site 345219007574 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 345219007575 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 345219007576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 345219007577 Walker A/P-loop; other site 345219007578 ATP binding site [chemical binding]; other site 345219007579 Q-loop/lid; other site 345219007580 ABC transporter signature motif; other site 345219007581 Walker B; other site 345219007582 D-loop; other site 345219007583 H-loop/switch region; other site 345219007584 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 345219007585 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 345219007586 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 345219007587 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 345219007588 active site 345219007589 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219007590 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219007591 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219007592 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 345219007593 ATP cone domain; Region: ATP-cone; pfam03477 345219007594 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 345219007595 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 345219007596 primosomal protein DnaI; Reviewed; Region: PRK08939 345219007597 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 345219007598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219007599 Walker A motif; other site 345219007600 ATP binding site [chemical binding]; other site 345219007601 Walker B motif; other site 345219007602 YtxC-like family; Region: YtxC; pfam08812 345219007603 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 345219007604 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 345219007605 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 345219007606 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 345219007607 active site 345219007608 dimer interface [polypeptide binding]; other site 345219007609 motif 1; other site 345219007610 motif 2; other site 345219007611 motif 3; other site 345219007612 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 345219007613 anticodon binding site; other site 345219007614 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219007615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219007616 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 345219007617 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 345219007618 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 345219007619 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 345219007620 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 345219007621 23S rRNA binding site [nucleotide binding]; other site 345219007622 L21 binding site [polypeptide binding]; other site 345219007623 L13 binding site [polypeptide binding]; other site 345219007624 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 345219007625 trimer interface [polypeptide binding]; other site 345219007626 active site 345219007627 O-Antigen ligase; Region: Wzy_C; pfam04932 345219007628 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 345219007629 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 345219007630 active site 345219007631 metal binding site [ion binding]; metal-binding site 345219007632 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 345219007633 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 345219007634 putative NAD(P) binding site [chemical binding]; other site 345219007635 substrate binding site [chemical binding]; other site 345219007636 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219007637 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219007638 dimer interface [polypeptide binding]; other site 345219007639 putative CheW interface [polypeptide binding]; other site 345219007640 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 345219007641 Predicted flavoprotein [General function prediction only]; Region: COG0431 345219007642 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 345219007643 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 345219007644 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 345219007645 Ligand Binding Site [chemical binding]; other site 345219007646 Predicted transcriptional regulators [Transcription]; Region: COG1695 345219007647 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 345219007648 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 345219007649 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 345219007650 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219007651 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219007652 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219007653 DDE superfamily endonuclease; Region: DDE_5; cl17874 345219007654 Small, acid-soluble spore protein I; Region: SSPI; pfam14098 345219007655 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 345219007656 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 345219007657 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 345219007658 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 345219007659 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 345219007660 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 345219007661 dimer interface [polypeptide binding]; other site 345219007662 motif 1; other site 345219007663 active site 345219007664 motif 2; other site 345219007665 motif 3; other site 345219007666 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 345219007667 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 345219007668 putative tRNA-binding site [nucleotide binding]; other site 345219007669 B3/4 domain; Region: B3_4; pfam03483 345219007670 tRNA synthetase B5 domain; Region: B5; smart00874 345219007671 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 345219007672 dimer interface [polypeptide binding]; other site 345219007673 motif 1; other site 345219007674 motif 3; other site 345219007675 motif 2; other site 345219007676 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 345219007677 ribonuclease HIII; Provisional; Region: PRK00996 345219007678 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 345219007679 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 345219007680 RNA/DNA hybrid binding site [nucleotide binding]; other site 345219007681 active site 345219007682 Cell division protein ZapA; Region: ZapA; cl01146 345219007683 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 345219007684 Colicin V production protein; Region: Colicin_V; pfam02674 345219007685 hypothetical protein; Provisional; Region: PRK08609 345219007686 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 345219007687 active site 345219007688 primer binding site [nucleotide binding]; other site 345219007689 NTP binding site [chemical binding]; other site 345219007690 metal binding triad [ion binding]; metal-binding site 345219007691 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 345219007692 active site 345219007693 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 345219007694 MutS domain III; Region: MutS_III; pfam05192 345219007695 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 345219007696 Walker A/P-loop; other site 345219007697 ATP binding site [chemical binding]; other site 345219007698 Q-loop/lid; other site 345219007699 ABC transporter signature motif; other site 345219007700 Walker B; other site 345219007701 D-loop; other site 345219007702 H-loop/switch region; other site 345219007703 Smr domain; Region: Smr; pfam01713 345219007704 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 345219007705 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 345219007706 acyl-activating enzyme (AAE) consensus motif; other site 345219007707 putative AMP binding site [chemical binding]; other site 345219007708 putative active site [active] 345219007709 putative CoA binding site [chemical binding]; other site 345219007710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219007711 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219007712 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 345219007713 enoyl-CoA hydratase; Provisional; Region: PRK07658 345219007714 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 345219007715 substrate binding site [chemical binding]; other site 345219007716 oxyanion hole (OAH) forming residues; other site 345219007717 trimer interface [polypeptide binding]; other site 345219007718 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 345219007719 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 345219007720 Ligand binding site [chemical binding]; other site 345219007721 Electron transfer flavoprotein domain; Region: ETF; pfam01012 345219007722 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 345219007723 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 345219007724 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 345219007725 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 345219007726 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 345219007727 catalytic residues [active] 345219007728 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 345219007729 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 345219007730 GIY-YIG motif/motif A; other site 345219007731 active site 345219007732 catalytic site [active] 345219007733 putative DNA binding site [nucleotide binding]; other site 345219007734 metal binding site [ion binding]; metal-binding site 345219007735 UvrB/uvrC motif; Region: UVR; pfam02151 345219007736 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 345219007737 aspartate kinase; Reviewed; Region: PRK06635 345219007738 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 345219007739 putative nucleotide binding site [chemical binding]; other site 345219007740 putative catalytic residues [active] 345219007741 putative Mg ion binding site [ion binding]; other site 345219007742 putative aspartate binding site [chemical binding]; other site 345219007743 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 345219007744 putative allosteric regulatory site; other site 345219007745 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 345219007746 putative allosteric regulatory residue; other site 345219007747 Protein of unknown function (DUF2507); Region: DUF2507; pfam10702 345219007748 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 345219007749 putative Iron-sulfur protein interface [polypeptide binding]; other site 345219007750 proximal heme binding site [chemical binding]; other site 345219007751 distal heme binding site [chemical binding]; other site 345219007752 putative dimer interface [polypeptide binding]; other site 345219007753 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 345219007754 L-aspartate oxidase; Provisional; Region: PRK06175 345219007755 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 345219007756 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 345219007757 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 345219007758 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 345219007759 active site 345219007760 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 345219007761 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 345219007762 DNA binding residues [nucleotide binding] 345219007763 dimerization interface [polypeptide binding]; other site 345219007764 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 345219007765 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 345219007766 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 345219007767 MarR family; Region: MarR; pfam01047 345219007768 glutamate racemase; Provisional; Region: PRK00865 345219007769 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 345219007770 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 345219007771 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 345219007772 NAD binding site [chemical binding]; other site 345219007773 catalytic Zn binding site [ion binding]; other site 345219007774 structural Zn binding site [ion binding]; other site 345219007775 Coat F domain; Region: Coat_F; cl17715 345219007776 Sporulation and spore germination; Region: Germane; pfam10646 345219007777 Spore germination protein [General function prediction only]; Region: COG5401 345219007778 Sporulation and spore germination; Region: Germane; pfam10646 345219007779 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 345219007780 active site 345219007781 dimerization interface [polypeptide binding]; other site 345219007782 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 345219007783 active site 345219007784 metal binding site [ion binding]; metal-binding site 345219007785 homotetramer interface [polypeptide binding]; other site 345219007786 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 345219007787 trigger factor; Provisional; Region: tig; PRK01490 345219007788 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 345219007789 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 345219007790 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 345219007791 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 345219007792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219007793 Walker A motif; other site 345219007794 ATP binding site [chemical binding]; other site 345219007795 Walker B motif; other site 345219007796 arginine finger; other site 345219007797 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 345219007798 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 345219007799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219007800 Walker A motif; other site 345219007801 ATP binding site [chemical binding]; other site 345219007802 Walker B motif; other site 345219007803 arginine finger; other site 345219007804 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 345219007805 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 345219007806 Found in ATP-dependent protease La (LON); Region: LON; smart00464 345219007807 Found in ATP-dependent protease La (LON); Region: LON; smart00464 345219007808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219007809 Walker A motif; other site 345219007810 ATP binding site [chemical binding]; other site 345219007811 Walker B motif; other site 345219007812 arginine finger; other site 345219007813 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 345219007814 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 345219007815 G1 box; other site 345219007816 GTP/Mg2+ binding site [chemical binding]; other site 345219007817 Switch I region; other site 345219007818 G2 box; other site 345219007819 G3 box; other site 345219007820 Switch II region; other site 345219007821 G4 box; other site 345219007822 G5 box; other site 345219007823 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 345219007824 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 345219007825 tRNA; other site 345219007826 putative tRNA binding site [nucleotide binding]; other site 345219007827 putative NADP binding site [chemical binding]; other site 345219007828 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 345219007829 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 345219007830 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 345219007831 domain interfaces; other site 345219007832 active site 345219007833 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 345219007834 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 345219007835 active site 345219007836 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 345219007837 dimer interface [polypeptide binding]; other site 345219007838 active site 345219007839 Schiff base residues; other site 345219007840 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 345219007841 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219007842 inhibitor-cofactor binding pocket; inhibition site 345219007843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219007844 catalytic residue [active] 345219007845 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 345219007846 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219007847 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 345219007848 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 345219007849 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 345219007850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 345219007851 active site 345219007852 HIGH motif; other site 345219007853 nucleotide binding site [chemical binding]; other site 345219007854 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 345219007855 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 345219007856 active site 345219007857 KMSKS motif; other site 345219007858 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 345219007859 tRNA binding surface [nucleotide binding]; other site 345219007860 anticodon binding site; other site 345219007861 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 345219007862 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 345219007863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 345219007864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 345219007865 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 345219007866 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 345219007867 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 345219007868 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 345219007869 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 345219007870 PRC-barrel domain; Region: PRC; pfam05239 345219007871 VanW like protein; Region: VanW; pfam04294 345219007872 G5 domain; Region: G5; pfam07501 345219007873 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 345219007874 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 345219007875 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 345219007876 Walker A motif; other site 345219007877 ATP binding site [chemical binding]; other site 345219007878 Walker B motif; other site 345219007879 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 345219007880 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 345219007881 Walker A motif; other site 345219007882 ATP binding site [chemical binding]; other site 345219007883 Walker B motif; other site 345219007884 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 345219007885 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 345219007886 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 345219007887 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 345219007888 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 345219007889 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 345219007890 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 345219007891 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 345219007892 hypothetical protein; Reviewed; Region: PRK00024 345219007893 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 345219007894 MPN+ (JAMM) motif; other site 345219007895 Zinc-binding site [ion binding]; other site 345219007896 rod shape-determining protein MreC; Provisional; Region: PRK13922 345219007897 Protein of unknown function (DUF972); Region: DUF972; pfam06156 345219007898 rod shape-determining protein MreC; Region: MreC; pfam04085 345219007899 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 345219007900 septum formation inhibitor; Reviewed; Region: minC; PRK00513 345219007901 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 345219007902 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 345219007903 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 345219007904 Switch I; other site 345219007905 Switch II; other site 345219007906 Peptidase family M23; Region: Peptidase_M23; pfam01551 345219007907 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 345219007908 Peptidase family M50; Region: Peptidase_M50; pfam02163 345219007909 active site 345219007910 putative substrate binding region [chemical binding]; other site 345219007911 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 345219007912 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 345219007913 homodimer interface [polypeptide binding]; other site 345219007914 oligonucleotide binding site [chemical binding]; other site 345219007915 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 345219007916 hypothetical protein; Provisional; Region: PRK14553 345219007917 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 345219007918 GTPase CgtA; Reviewed; Region: obgE; PRK12297 345219007919 GTP1/OBG; Region: GTP1_OBG; pfam01018 345219007920 Obg GTPase; Region: Obg; cd01898 345219007921 G1 box; other site 345219007922 GTP/Mg2+ binding site [chemical binding]; other site 345219007923 Switch I region; other site 345219007924 G2 box; other site 345219007925 G3 box; other site 345219007926 Switch II region; other site 345219007927 G4 box; other site 345219007928 G5 box; other site 345219007929 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 345219007930 hypothetical protein; Provisional; Region: PRK04435 345219007931 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 345219007932 prephenate dehydratase; Provisional; Region: PRK11898 345219007933 Prephenate dehydratase; Region: PDT; pfam00800 345219007934 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 345219007935 putative L-Phe binding site [chemical binding]; other site 345219007936 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 345219007937 HTH domain; Region: HTH_11; pfam08279 345219007938 3H domain; Region: 3H; pfam02829 345219007939 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 345219007940 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219007941 Phosphotransferase enzyme family; Region: APH; pfam01636 345219007942 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 345219007943 hypothetical protein; Validated; Region: PRK00110 345219007944 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 345219007945 RuvA N terminal domain; Region: RuvA_N; pfam01330 345219007946 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 345219007947 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 345219007948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219007949 Walker A motif; other site 345219007950 ATP binding site [chemical binding]; other site 345219007951 Walker B motif; other site 345219007952 arginine finger; other site 345219007953 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 345219007954 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 345219007955 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 345219007956 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 345219007957 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 345219007958 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 345219007959 Preprotein translocase subunit; Region: YajC; pfam02699 345219007960 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 345219007961 Predicted membrane protein [Function unknown]; Region: COG2323 345219007962 stage V sporulation protein B; Region: spore_V_B; TIGR02900 345219007963 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 345219007964 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 345219007965 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 345219007966 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 345219007967 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 345219007968 Protein export membrane protein; Region: SecD_SecF; pfam02355 345219007969 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 345219007970 DHH family; Region: DHH; pfam01368 345219007971 DHHA1 domain; Region: DHHA1; pfam02272 345219007972 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 345219007973 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219007974 active site 345219007975 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 345219007976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219007977 Zn2+ binding site [ion binding]; other site 345219007978 Mg2+ binding site [ion binding]; other site 345219007979 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 345219007980 synthetase active site [active] 345219007981 NTP binding site [chemical binding]; other site 345219007982 metal binding site [ion binding]; metal-binding site 345219007983 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 345219007984 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 345219007985 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 345219007986 putative active site [active] 345219007987 dimerization interface [polypeptide binding]; other site 345219007988 putative tRNAtyr binding site [nucleotide binding]; other site 345219007989 MarR family; Region: MarR; pfam01047 345219007990 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 345219007991 carboxyltransferase (CT) interaction site; other site 345219007992 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 345219007993 biotinylation site [posttranslational modification]; other site 345219007994 HlyD family secretion protein; Region: HlyD_3; pfam13437 345219007995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219007996 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 345219007997 putative substrate translocation pore; other site 345219007998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219007999 Bacterial SH3 domain homologues; Region: SH3b; smart00287 345219008000 Bacterial SH3 domain; Region: SH3_3; pfam08239 345219008001 Bacterial SH3 domain; Region: SH3_3; pfam08239 345219008002 Bacterial SH3 domain; Region: SH3_3; cl17532 345219008003 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 345219008004 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 345219008005 active site 345219008006 metal binding site [ion binding]; metal-binding site 345219008007 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 345219008008 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 345219008009 dimer interface [polypeptide binding]; other site 345219008010 motif 1; other site 345219008011 active site 345219008012 motif 2; other site 345219008013 motif 3; other site 345219008014 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 345219008015 anticodon binding site; other site 345219008016 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 345219008017 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 345219008018 dimer interface [polypeptide binding]; other site 345219008019 anticodon binding site; other site 345219008020 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 345219008021 homodimer interface [polypeptide binding]; other site 345219008022 motif 1; other site 345219008023 active site 345219008024 motif 2; other site 345219008025 GAD domain; Region: GAD; pfam02938 345219008026 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 345219008027 motif 3; other site 345219008028 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 345219008029 Sodium Bile acid symporter family; Region: SBF; cl17470 345219008030 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 345219008031 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 345219008032 putative ATP binding site [chemical binding]; other site 345219008033 putative substrate interface [chemical binding]; other site 345219008034 recombination factor protein RarA; Reviewed; Region: PRK13342 345219008035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219008036 Walker A motif; other site 345219008037 ATP binding site [chemical binding]; other site 345219008038 Walker B motif; other site 345219008039 arginine finger; other site 345219008040 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 345219008041 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 345219008042 classical (c) SDRs; Region: SDR_c; cd05233 345219008043 NAD(P) binding site [chemical binding]; other site 345219008044 active site 345219008045 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219008046 Predicted transcriptional regulator [Transcription]; Region: COG1959 345219008047 Transcriptional regulator; Region: Rrf2; pfam02082 345219008048 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 345219008049 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 345219008050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 345219008051 catalytic residue [active] 345219008052 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 345219008053 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 345219008054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219008055 binding surface 345219008056 TPR motif; other site 345219008057 TPR repeat; Region: TPR_11; pfam13414 345219008058 TPR repeat; Region: TPR_11; pfam13414 345219008059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219008060 binding surface 345219008061 TPR motif; other site 345219008062 TPR repeat; Region: TPR_11; pfam13414 345219008063 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 345219008064 AAA domain; Region: AAA_30; pfam13604 345219008065 Family description; Region: UvrD_C_2; pfam13538 345219008066 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 345219008067 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 345219008068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 345219008069 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 345219008070 AsnC family; Region: AsnC_trans_reg; pfam01037 345219008071 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 345219008072 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 345219008073 Domain of unknown function DUF20; Region: UPF0118; pfam01594 345219008074 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 345219008075 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 345219008076 motif 1; other site 345219008077 active site 345219008078 motif 2; other site 345219008079 motif 3; other site 345219008080 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 345219008081 DHHA1 domain; Region: DHHA1; pfam02272 345219008082 hypothetical protein; Provisional; Region: PRK05473 345219008083 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 345219008084 hypothetical protein; Provisional; Region: PRK13678 345219008085 YceG-like family; Region: YceG; pfam02618 345219008086 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 345219008087 dimerization interface [polypeptide binding]; other site 345219008088 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 345219008089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219008090 S-adenosylmethionine binding site [chemical binding]; other site 345219008091 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 345219008092 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 345219008093 ATP-binding site [chemical binding]; other site 345219008094 Sugar specificity; other site 345219008095 Pyrimidine base specificity; other site 345219008096 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 345219008097 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 345219008098 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 345219008099 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 345219008100 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 345219008101 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 345219008102 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 345219008103 YrhC-like protein; Region: YrhC; pfam14143 345219008104 Probable sporulation protein (Bac_small_yrzI); Region: Bac_small_YrzI; cl09734 345219008105 peroxiredoxin; Region: AhpC; TIGR03137 345219008106 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 345219008107 dimer interface [polypeptide binding]; other site 345219008108 decamer (pentamer of dimers) interface [polypeptide binding]; other site 345219008109 catalytic triad [active] 345219008110 peroxidatic and resolving cysteines [active] 345219008111 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 345219008112 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 345219008113 catalytic residue [active] 345219008114 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 345219008115 catalytic residues [active] 345219008116 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219008117 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219008118 sporulation sigma factor SigK; Reviewed; Region: PRK05803 345219008119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219008120 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219008121 DNA binding residues [nucleotide binding] 345219008122 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 345219008123 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 345219008124 Sporulation inhibitor A; Region: Sda; pfam08970 345219008125 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 345219008126 CCC1-related family of proteins; Region: CCC1_like; cl00278 345219008127 CrcB-like protein; Region: CRCB; cl09114 345219008128 CrcB-like protein; Region: CRCB; cl09114 345219008129 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 345219008130 Repair protein; Region: Repair_PSII; pfam04536 345219008131 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 345219008132 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 345219008133 catalytic residues [active] 345219008134 Short C-terminal domain; Region: SHOCT; pfam09851 345219008135 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 345219008136 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 345219008137 putative dimer interface [polypeptide binding]; other site 345219008138 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 345219008139 Multicopper oxidase; Region: Cu-oxidase; pfam00394 345219008140 Short C-terminal domain; Region: SHOCT; pfam09851 345219008141 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 345219008142 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219008143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219008144 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 345219008145 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 345219008146 active site residue [active] 345219008147 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 345219008148 CPxP motif; other site 345219008149 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 345219008150 active site residue [active] 345219008151 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 345219008152 catalytic residues [active] 345219008153 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 345219008154 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 345219008155 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 345219008156 putative dimer interface [polypeptide binding]; other site 345219008157 multicopper oxidase; Provisional; Region: PRK10965 345219008158 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 345219008159 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 345219008160 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 345219008161 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 345219008162 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 345219008163 FAD binding domain; Region: FAD_binding_4; pfam01565 345219008164 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 345219008165 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 345219008166 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 345219008167 Cysteine-rich domain; Region: CCG; pfam02754 345219008168 Cysteine-rich domain; Region: CCG; pfam02754 345219008169 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 345219008170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219008171 active site 345219008172 motif I; other site 345219008173 motif II; other site 345219008174 GTPase YqeH; Provisional; Region: PRK13796 345219008175 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 345219008176 GTP/Mg2+ binding site [chemical binding]; other site 345219008177 G4 box; other site 345219008178 G5 box; other site 345219008179 G1 box; other site 345219008180 Switch I region; other site 345219008181 G2 box; other site 345219008182 G3 box; other site 345219008183 Switch II region; other site 345219008184 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 345219008185 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 345219008186 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 345219008187 shikimate binding site; other site 345219008188 NAD(P) binding site [chemical binding]; other site 345219008189 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 345219008190 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 345219008191 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 345219008192 active site 345219008193 (T/H)XGH motif; other site 345219008194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219008195 Zn2+ binding site [ion binding]; other site 345219008196 Mg2+ binding site [ion binding]; other site 345219008197 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 345219008198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219008199 S-adenosylmethionine binding site [chemical binding]; other site 345219008200 late competence protein ComER; Validated; Region: PRK07680 345219008201 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 345219008202 SLBB domain; Region: SLBB; pfam10531 345219008203 comEA protein; Region: comE; TIGR01259 345219008204 Helix-hairpin-helix motif; Region: HHH; pfam00633 345219008205 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 345219008206 catalytic motif [active] 345219008207 Zn binding site [ion binding]; other site 345219008208 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 345219008209 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 345219008210 Competence protein; Region: Competence; pfam03772 345219008211 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 345219008212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 345219008213 YqzM-like protein; Region: YqzM; pfam14141 345219008214 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 345219008215 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 345219008216 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 345219008217 germination protease; Provisional; Region: PRK02858 345219008218 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 345219008219 stage II sporulation protein P; Region: spore_II_P; TIGR02867 345219008220 GTP-binding protein LepA; Provisional; Region: PRK05433 345219008221 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 345219008222 G1 box; other site 345219008223 putative GEF interaction site [polypeptide binding]; other site 345219008224 GTP/Mg2+ binding site [chemical binding]; other site 345219008225 Switch I region; other site 345219008226 G2 box; other site 345219008227 G3 box; other site 345219008228 Switch II region; other site 345219008229 G4 box; other site 345219008230 G5 box; other site 345219008231 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 345219008232 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 345219008233 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 345219008234 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 345219008235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219008236 FeS/SAM binding site; other site 345219008237 HemN C-terminal domain; Region: HemN_C; pfam06969 345219008238 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 345219008239 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 345219008240 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 345219008241 dimer interface [polypeptide binding]; other site 345219008242 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 345219008243 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 345219008244 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 345219008245 nucleotide binding site [chemical binding]; other site 345219008246 NEF interaction site [polypeptide binding]; other site 345219008247 SBD interface [polypeptide binding]; other site 345219008248 chaperone protein DnaJ; Provisional; Region: PRK14280 345219008249 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 345219008250 HSP70 interaction site [polypeptide binding]; other site 345219008251 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 345219008252 substrate binding site [polypeptide binding]; other site 345219008253 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 345219008254 Zn binding sites [ion binding]; other site 345219008255 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 345219008256 dimer interface [polypeptide binding]; other site 345219008257 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 345219008258 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 345219008259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219008260 S-adenosylmethionine binding site [chemical binding]; other site 345219008261 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 345219008262 RNA methyltransferase, RsmE family; Region: TIGR00046 345219008263 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 345219008264 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 345219008265 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219008266 FeS/SAM binding site; other site 345219008267 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 345219008268 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 345219008269 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 345219008270 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 345219008271 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 345219008272 Yqey-like protein; Region: YqeY; pfam09424 345219008273 sporulation protein YqfC; Region: spore_yqfC; TIGR02856 345219008274 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 345219008275 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 345219008276 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 345219008277 PhoH-like protein; Region: PhoH; pfam02562 345219008278 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 345219008279 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 345219008280 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219008281 Zn2+ binding site [ion binding]; other site 345219008282 Mg2+ binding site [ion binding]; other site 345219008283 metal-binding heat shock protein; Provisional; Region: PRK00016 345219008284 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 345219008285 GTPase Era; Reviewed; Region: era; PRK00089 345219008286 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 345219008287 G1 box; other site 345219008288 GTP/Mg2+ binding site [chemical binding]; other site 345219008289 Switch I region; other site 345219008290 G2 box; other site 345219008291 Switch II region; other site 345219008292 G3 box; other site 345219008293 G4 box; other site 345219008294 G5 box; other site 345219008295 KH domain; Region: KH_2; pfam07650 345219008296 YqzL-like protein; Region: YqzL; pfam14006 345219008297 DNA repair protein RecO; Region: reco; TIGR00613 345219008298 Recombination protein O N terminal; Region: RecO_N; pfam11967 345219008299 Recombination protein O C terminal; Region: RecO_C; pfam02565 345219008300 HTH domain; Region: HTH_11; pfam08279 345219008301 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 345219008302 FOG: CBS domain [General function prediction only]; Region: COG0517 345219008303 PEP synthetase regulatory protein; Provisional; Region: PRK05339 345219008304 DNA primase; Validated; Region: dnaG; PRK05667 345219008305 CHC2 zinc finger; Region: zf-CHC2; pfam01807 345219008306 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 345219008307 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 345219008308 active site 345219008309 metal binding site [ion binding]; metal-binding site 345219008310 interdomain interaction site; other site 345219008311 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 345219008312 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 345219008313 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 345219008314 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 345219008315 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 345219008316 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219008317 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 345219008318 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219008319 DNA binding residues [nucleotide binding] 345219008320 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 345219008321 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 345219008322 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 345219008323 Family of unknown function (DUF633); Region: DUF633; pfam04816 345219008324 Uncharacterized conserved protein [Function unknown]; Region: COG0327 345219008325 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 345219008326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 345219008327 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 345219008328 Uncharacterized conserved protein [Function unknown]; Region: COG0327 345219008329 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 345219008330 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 345219008331 YqfQ-like protein; Region: YqfQ; pfam14181 345219008332 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 345219008333 DEAD-like helicases superfamily; Region: DEXDc; smart00487 345219008334 ATP binding site [chemical binding]; other site 345219008335 Mg++ binding site [ion binding]; other site 345219008336 motif III; other site 345219008337 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219008338 nucleotide binding region [chemical binding]; other site 345219008339 ATP-binding site [chemical binding]; other site 345219008340 endonuclease IV; Provisional; Region: PRK01060 345219008341 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 345219008342 AP (apurinic/apyrimidinic) site pocket; other site 345219008343 DNA interaction; other site 345219008344 Metal-binding active site; metal-binding site 345219008345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 345219008346 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 345219008347 NlpC/P60 family; Region: NLPC_P60; pfam00877 345219008348 Protein of unknown function (DUF2624); Region: DUF2624; pfam11116 345219008349 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 345219008350 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 345219008351 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 345219008352 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 345219008353 ABC-ATPase subunit interface; other site 345219008354 dimer interface [polypeptide binding]; other site 345219008355 putative PBP binding regions; other site 345219008356 ferric uptake regulator; Provisional; Region: fur; PRK09462 345219008357 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 345219008358 metal binding site 2 [ion binding]; metal-binding site 345219008359 putative DNA binding helix; other site 345219008360 metal binding site 1 [ion binding]; metal-binding site 345219008361 dimer interface [polypeptide binding]; other site 345219008362 structural Zn2+ binding site [ion binding]; other site 345219008363 Uncharacterized conserved protein [Function unknown]; Region: COG5663 345219008364 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 345219008365 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 345219008366 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 345219008367 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 345219008368 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 345219008369 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 345219008370 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219008371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219008372 putative substrate translocation pore; other site 345219008373 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 345219008374 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 345219008375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 345219008376 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 345219008377 Rhomboid family; Region: Rhomboid; pfam01694 345219008378 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 345219008379 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 345219008380 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 345219008381 nucleotide binding site [chemical binding]; other site 345219008382 Protein of unknown function (DUF2759); Region: DUF2759; pfam10958 345219008383 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 345219008384 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 345219008385 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219008386 dimerization interface [polypeptide binding]; other site 345219008387 putative DNA binding site [nucleotide binding]; other site 345219008388 Predicted transcriptional regulator [Transcription]; Region: COG2345 345219008389 putative Zn2+ binding site [ion binding]; other site 345219008390 Type II/IV secretion system protein; Region: T2SE; pfam00437 345219008391 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 345219008392 Walker A motif; other site 345219008393 ATP binding site [chemical binding]; other site 345219008394 Walker B motif; other site 345219008395 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 345219008396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 345219008397 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 345219008398 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 345219008399 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 345219008400 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 345219008401 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 345219008402 ComG operon protein 7; Region: ComGG; pfam14173 345219008403 shikimate kinase; Reviewed; Region: aroK; PRK00131 345219008404 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 345219008405 ADP binding site [chemical binding]; other site 345219008406 magnesium binding site [ion binding]; other site 345219008407 putative shikimate binding site; other site 345219008408 YqzE-like protein; Region: YqzE; pfam14038 345219008409 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 345219008410 DEAD-like helicases superfamily; Region: DEXDc; smart00487 345219008411 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219008412 ATP binding site [chemical binding]; other site 345219008413 putative Mg++ binding site [ion binding]; other site 345219008414 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219008415 nucleotide binding region [chemical binding]; other site 345219008416 ATP-binding site [chemical binding]; other site 345219008417 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 345219008418 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 345219008419 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 345219008420 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 345219008421 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 345219008422 tetramer interface [polypeptide binding]; other site 345219008423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219008424 catalytic residue [active] 345219008425 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 345219008426 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 345219008427 tetramer interface [polypeptide binding]; other site 345219008428 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219008429 catalytic residue [active] 345219008430 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 345219008431 active site residue [active] 345219008432 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 345219008433 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08115 345219008434 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 345219008435 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 345219008436 active site 345219008437 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 345219008438 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219008439 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 345219008440 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 345219008441 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 345219008442 NAD(P) binding site [chemical binding]; other site 345219008443 catalytic residues [active] 345219008444 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 345219008445 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 345219008446 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 345219008447 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 345219008448 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 345219008449 dimer interface [polypeptide binding]; other site 345219008450 active site 345219008451 PaaX-like protein; Region: PaaX; pfam07848 345219008452 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 345219008453 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 345219008454 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 345219008455 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 345219008456 FMN binding site [chemical binding]; other site 345219008457 substrate binding site [chemical binding]; other site 345219008458 putative catalytic residue [active] 345219008459 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 345219008460 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 345219008461 active site 345219008462 nucleophile elbow; other site 345219008463 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 345219008464 Conserved membrane protein YqhR; Region: YqhR; pfam11085 345219008465 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 345219008466 Dehydroquinase class II; Region: DHquinase_II; pfam01220 345219008467 active site 345219008468 trimer interface [polypeptide binding]; other site 345219008469 dimer interface [polypeptide binding]; other site 345219008470 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 345219008471 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 345219008472 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 345219008473 active site 345219008474 elongation factor P; Validated; Region: PRK00529 345219008475 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 345219008476 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 345219008477 RNA binding site [nucleotide binding]; other site 345219008478 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 345219008479 RNA binding site [nucleotide binding]; other site 345219008480 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 345219008481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219008482 Walker A/P-loop; other site 345219008483 ATP binding site [chemical binding]; other site 345219008484 Q-loop/lid; other site 345219008485 ABC transporter signature motif; other site 345219008486 Walker B; other site 345219008487 H-loop/switch region; other site 345219008488 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 345219008489 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 345219008490 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 345219008491 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 345219008492 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 345219008493 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 345219008494 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 345219008495 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 345219008496 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 345219008497 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 345219008498 carboxyltransferase (CT) interaction site; other site 345219008499 biotinylation site [posttranslational modification]; other site 345219008500 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 345219008501 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219008502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 345219008503 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 345219008504 Asp23 family; Region: Asp23; pfam03780 345219008505 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 345219008506 putative RNA binding site [nucleotide binding]; other site 345219008507 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 345219008508 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 345219008509 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 345219008510 homodimer interface [polypeptide binding]; other site 345219008511 NADP binding site [chemical binding]; other site 345219008512 substrate binding site [chemical binding]; other site 345219008513 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 345219008514 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 345219008515 generic binding surface II; other site 345219008516 generic binding surface I; other site 345219008517 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 345219008518 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 345219008519 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 345219008520 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 345219008521 substrate binding pocket [chemical binding]; other site 345219008522 chain length determination region; other site 345219008523 substrate-Mg2+ binding site; other site 345219008524 catalytic residues [active] 345219008525 aspartate-rich region 1; other site 345219008526 active site lid residues [active] 345219008527 aspartate-rich region 2; other site 345219008528 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 345219008529 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 345219008530 TPP-binding site; other site 345219008531 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 345219008532 PYR/PP interface [polypeptide binding]; other site 345219008533 dimer interface [polypeptide binding]; other site 345219008534 TPP binding site [chemical binding]; other site 345219008535 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 345219008536 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 345219008537 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219008538 RNA binding surface [nucleotide binding]; other site 345219008539 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 345219008540 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 345219008541 arginine repressor; Provisional; Region: PRK04280 345219008542 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 345219008543 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 345219008544 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 345219008545 Walker A/P-loop; other site 345219008546 ATP binding site [chemical binding]; other site 345219008547 Q-loop/lid; other site 345219008548 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 345219008549 ABC transporter signature motif; other site 345219008550 Walker B; other site 345219008551 D-loop; other site 345219008552 H-loop/switch region; other site 345219008553 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 345219008554 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 345219008555 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 345219008556 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 345219008557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219008558 active site 345219008559 phosphorylation site [posttranslational modification] 345219008560 intermolecular recognition site; other site 345219008561 dimerization interface [polypeptide binding]; other site 345219008562 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 345219008563 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 345219008564 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 345219008565 active site 345219008566 catalytic site [active] 345219008567 metal binding site [ion binding]; metal-binding site 345219008568 dimer interface [polypeptide binding]; other site 345219008569 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 345219008570 PAS domain S-box; Region: sensory_box; TIGR00229 345219008571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219008572 putative active site [active] 345219008573 heme pocket [chemical binding]; other site 345219008574 PAS domain S-box; Region: sensory_box; TIGR00229 345219008575 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219008576 putative active site [active] 345219008577 heme pocket [chemical binding]; other site 345219008578 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219008579 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 345219008580 Walker A motif; other site 345219008581 ATP binding site [chemical binding]; other site 345219008582 Walker B motif; other site 345219008583 arginine finger; other site 345219008584 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219008585 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 345219008586 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 345219008587 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 345219008588 NAD binding site [chemical binding]; other site 345219008589 Phe binding site; other site 345219008590 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 345219008591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219008592 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 345219008593 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 345219008594 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 345219008595 tetramer interface [polypeptide binding]; other site 345219008596 TPP-binding site [chemical binding]; other site 345219008597 heterodimer interface [polypeptide binding]; other site 345219008598 phosphorylation loop region [posttranslational modification] 345219008599 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 345219008600 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 345219008601 alpha subunit interface [polypeptide binding]; other site 345219008602 TPP binding site [chemical binding]; other site 345219008603 heterodimer interface [polypeptide binding]; other site 345219008604 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 345219008605 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 345219008606 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 345219008607 E3 interaction surface; other site 345219008608 lipoyl attachment site [posttranslational modification]; other site 345219008609 e3 binding domain; Region: E3_binding; pfam02817 345219008610 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 345219008611 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 345219008612 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 345219008613 putative substrate binding site [chemical binding]; other site 345219008614 putative ATP binding site [chemical binding]; other site 345219008615 Disulphide isomerase; Region: Disulph_isomer; pfam06491 345219008616 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 345219008617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 345219008618 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 345219008619 peptidase T-like protein; Region: PepT-like; TIGR01883 345219008620 metal binding site [ion binding]; metal-binding site 345219008621 putative dimer interface [polypeptide binding]; other site 345219008622 CheW-like domain; Region: CheW; pfam01584 345219008623 DNA polymerase IV; Validated; Region: PRK01810 345219008624 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 345219008625 active site 345219008626 DNA binding site [nucleotide binding] 345219008627 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 345219008628 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 345219008629 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 345219008630 ribonuclease Z; Region: RNase_Z; TIGR02651 345219008631 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 345219008632 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 345219008633 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 345219008634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219008635 NAD(P) binding site [chemical binding]; other site 345219008636 active site 345219008637 DNA polymerase IV; Reviewed; Region: PRK03103 345219008638 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 345219008639 active site 345219008640 DNA binding site [nucleotide binding] 345219008641 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 345219008642 YolD-like protein; Region: YolD; pfam08863 345219008643 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 345219008644 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219008645 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 345219008646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219008647 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219008648 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 345219008649 active site 345219008650 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 345219008651 PhoPQ-activated pathogenicity-related protein; Region: PhoPQ_related; cl01750 345219008652 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 345219008653 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; pfam10112 345219008654 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 345219008655 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 345219008656 active site 345219008657 catalytic tetrad [active] 345219008658 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 345219008659 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 345219008660 dimer interface [polypeptide binding]; other site 345219008661 ADP-ribose binding site [chemical binding]; other site 345219008662 active site 345219008663 nudix motif; other site 345219008664 metal binding site [ion binding]; metal-binding site 345219008665 TIGR00375 family protein; Region: TIGR00375 345219008666 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 345219008667 PHP-associated; Region: PHP_C; pfam13263 345219008668 Integral membrane protein DUF95; Region: DUF95; cl00572 345219008669 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 345219008670 metal binding site 2 [ion binding]; metal-binding site 345219008671 putative DNA binding helix; other site 345219008672 metal binding site 1 [ion binding]; metal-binding site 345219008673 dimer interface [polypeptide binding]; other site 345219008674 structural Zn2+ binding site [ion binding]; other site 345219008675 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 345219008676 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 345219008677 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 345219008678 active site 345219008679 Int/Topo IB signature motif; other site 345219008680 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 345219008681 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 345219008682 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 345219008683 anti-sigma F factor antagonist; Region: spore_II_AA; TIGR02886 345219008684 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 345219008685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219008686 ATP binding site [chemical binding]; other site 345219008687 Mg2+ binding site [ion binding]; other site 345219008688 G-X-G motif; other site 345219008689 sporulation sigma factor SigF; Validated; Region: PRK05572 345219008690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 345219008691 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 345219008692 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 345219008693 DNA binding residues [nucleotide binding] 345219008694 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 345219008695 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 345219008696 Stage V sporulation protein AE1; Region: SpoVAE; pfam14097 345219008697 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 345219008698 diaminopimelate decarboxylase; Region: lysA; TIGR01048 345219008699 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 345219008700 active site 345219008701 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 345219008702 substrate binding site [chemical binding]; other site 345219008703 catalytic residues [active] 345219008704 dimer interface [polypeptide binding]; other site 345219008705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219008706 Coenzyme A binding pocket [chemical binding]; other site 345219008707 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 345219008708 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 345219008709 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 345219008710 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 345219008711 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 345219008712 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 345219008713 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 345219008714 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 345219008715 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 345219008716 RNA binding surface [nucleotide binding]; other site 345219008717 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 345219008718 active site 345219008719 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 345219008720 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 345219008721 catalytic residues [active] 345219008722 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 345219008723 ResB-like family; Region: ResB; pfam05140 345219008724 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 345219008725 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 345219008726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219008727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219008728 active site 345219008729 phosphorylation site [posttranslational modification] 345219008730 intermolecular recognition site; other site 345219008731 dimerization interface [polypeptide binding]; other site 345219008732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219008733 DNA binding site [nucleotide binding] 345219008734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 345219008735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219008736 dimerization interface [polypeptide binding]; other site 345219008737 PAS domain; Region: PAS; smart00091 345219008738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219008739 dimer interface [polypeptide binding]; other site 345219008740 phosphorylation site [posttranslational modification] 345219008741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219008742 ATP binding site [chemical binding]; other site 345219008743 Mg2+ binding site [ion binding]; other site 345219008744 G-X-G motif; other site 345219008745 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 345219008746 Peptidase family M23; Region: Peptidase_M23; pfam01551 345219008747 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 345219008748 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219008749 Predicted membrane protein [Function unknown]; Region: COG3601 345219008750 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 345219008751 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 345219008752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 345219008753 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 345219008754 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219008755 ATP binding site [chemical binding]; other site 345219008756 putative Mg++ binding site [ion binding]; other site 345219008757 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219008758 nucleotide binding region [chemical binding]; other site 345219008759 ATP-binding site [chemical binding]; other site 345219008760 CAAX protease self-immunity; Region: Abi; pfam02517 345219008761 Protein of unknown function (DUF2663); Region: DUF2663; pfam10864 345219008762 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 345219008763 dimanganese center [ion binding]; other site 345219008764 CotJB protein; Region: CotJB; pfam12652 345219008765 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 345219008766 phosphodiesterase YaeI; Provisional; Region: PRK11340 345219008767 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 345219008768 putative active site [active] 345219008769 putative metal binding site [ion binding]; other site 345219008770 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 345219008771 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 345219008772 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 345219008773 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 345219008774 NAD(P) binding site [chemical binding]; other site 345219008775 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 345219008776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 345219008777 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219008778 Protease prsW family; Region: PrsW-protease; pfam13367 345219008779 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 345219008780 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 345219008781 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 345219008782 potential frameshift: common BLAST hit: gi|336114250|ref|YP_004569017.1| proteptide PepSY amd peptidase M4 345219008783 germination protein YpeB; Region: spore_YpeB; TIGR02889 345219008784 germination protein YpeB; Region: spore_YpeB; TIGR02889 345219008785 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 345219008786 Flagellar protein YcgR; Region: YcgR_2; pfam12945 345219008787 PilZ domain; Region: PilZ; pfam07238 345219008788 cytidylate kinase; Provisional; Region: cmk; PRK00023 345219008789 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 345219008790 CMP-binding site; other site 345219008791 The sites determining sugar specificity; other site 345219008792 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 345219008793 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 345219008794 RNA binding site [nucleotide binding]; other site 345219008795 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 345219008796 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 345219008797 RNA binding site [nucleotide binding]; other site 345219008798 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 345219008799 RNA binding site [nucleotide binding]; other site 345219008800 YpzI-like protein; Region: YpzI; pfam14140 345219008801 GTP-binding protein Der; Reviewed; Region: PRK00093 345219008802 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 345219008803 G1 box; other site 345219008804 GTP/Mg2+ binding site [chemical binding]; other site 345219008805 Switch I region; other site 345219008806 G2 box; other site 345219008807 Switch II region; other site 345219008808 G3 box; other site 345219008809 G4 box; other site 345219008810 G5 box; other site 345219008811 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 345219008812 G1 box; other site 345219008813 GTP/Mg2+ binding site [chemical binding]; other site 345219008814 Switch I region; other site 345219008815 G2 box; other site 345219008816 G3 box; other site 345219008817 Switch II region; other site 345219008818 G4 box; other site 345219008819 G5 box; other site 345219008820 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 345219008821 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 345219008822 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 345219008823 Protein of unknown function (DUF2768); Region: DUF2768; pfam10966 345219008824 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 345219008825 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 345219008826 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 345219008827 IHF dimer interface [polypeptide binding]; other site 345219008828 IHF - DNA interface [nucleotide binding]; other site 345219008829 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 345219008830 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 345219008831 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 345219008832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219008833 S-adenosylmethionine binding site [chemical binding]; other site 345219008834 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 345219008835 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 345219008836 substrate binding pocket [chemical binding]; other site 345219008837 chain length determination region; other site 345219008838 substrate-Mg2+ binding site; other site 345219008839 catalytic residues [active] 345219008840 aspartate-rich region 1; other site 345219008841 active site lid residues [active] 345219008842 aspartate-rich region 2; other site 345219008843 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 345219008844 active site 345219008845 multimer interface [polypeptide binding]; other site 345219008846 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 345219008847 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 345219008848 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 345219008849 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 345219008850 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 345219008851 Tetramer interface [polypeptide binding]; other site 345219008852 active site 345219008853 FMN-binding site [chemical binding]; other site 345219008854 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 345219008855 active site 345219008856 dimer interface [polypeptide binding]; other site 345219008857 metal binding site [ion binding]; metal-binding site 345219008858 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 345219008859 homotrimer interaction site [polypeptide binding]; other site 345219008860 active site 345219008861 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 345219008862 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219008863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219008864 homodimer interface [polypeptide binding]; other site 345219008865 catalytic residue [active] 345219008866 prephenate dehydrogenase; Validated; Region: PRK06545 345219008867 prephenate dehydrogenase; Validated; Region: PRK08507 345219008868 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 345219008869 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 345219008870 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 345219008871 hinge; other site 345219008872 active site 345219008873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219008874 binding surface 345219008875 TPR motif; other site 345219008876 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 345219008877 binding surface 345219008878 TPR motif; other site 345219008879 TPR repeat; Region: TPR_11; pfam13414 345219008880 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219008881 binding surface 345219008882 TPR motif; other site 345219008883 TPR repeat; Region: TPR_11; pfam13414 345219008884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 345219008885 binding surface 345219008886 TPR motif; other site 345219008887 hypothetical protein; Provisional; Region: PRK03636 345219008888 UPF0302 domain; Region: UPF0302; pfam08864 345219008889 IDEAL domain; Region: IDEAL; pfam08858 345219008890 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 345219008891 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 345219008892 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 345219008893 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 345219008894 iron-sulfur cluster [ion binding]; other site 345219008895 [2Fe-2S] cluster binding site [ion binding]; other site 345219008896 cytochrome b6; Provisional; Region: PRK03735 345219008897 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 345219008898 interchain domain interface [polypeptide binding]; other site 345219008899 intrachain domain interface; other site 345219008900 heme bH binding site [chemical binding]; other site 345219008901 Qi binding site; other site 345219008902 heme bL binding site [chemical binding]; other site 345219008903 Qo binding site; other site 345219008904 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 345219008905 interchain domain interface [polypeptide binding]; other site 345219008906 intrachain domain interface; other site 345219008907 Qi binding site; other site 345219008908 Qo binding site; other site 345219008909 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 345219008910 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 345219008911 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 345219008912 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 345219008913 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 345219008914 QueT transporter; Region: QueT; pfam06177 345219008915 Uncharacterized conserved protein [Function unknown]; Region: COG1284 345219008916 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219008917 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219008918 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 345219008919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 345219008920 homodimer interface [polypeptide binding]; other site 345219008921 metal binding site [ion binding]; metal-binding site 345219008922 dihydrodipicolinate reductase; Provisional; Region: PRK00048 345219008923 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 345219008924 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 345219008925 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 345219008926 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 345219008927 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 345219008928 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 345219008929 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 345219008930 active site 345219008931 NTP binding site [chemical binding]; other site 345219008932 metal binding triad [ion binding]; metal-binding site 345219008933 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 345219008934 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 345219008935 Biotin operon repressor [Transcription]; Region: BirA; COG1654 345219008936 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 345219008937 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 345219008938 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 345219008939 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 345219008940 oligomerization interface [polypeptide binding]; other site 345219008941 active site 345219008942 metal binding site [ion binding]; metal-binding site 345219008943 pantoate--beta-alanine ligase; Region: panC; TIGR00018 345219008944 Pantoate-beta-alanine ligase; Region: PanC; cd00560 345219008945 active site 345219008946 ATP-binding site [chemical binding]; other site 345219008947 pantoate-binding site; other site 345219008948 HXXH motif; other site 345219008949 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 345219008950 tetramerization interface [polypeptide binding]; other site 345219008951 active site 345219008952 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 345219008953 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 345219008954 active site 345219008955 catalytic site [active] 345219008956 substrate binding site [chemical binding]; other site 345219008957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 345219008958 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 345219008959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 345219008960 aspartate aminotransferase; Provisional; Region: PRK05764 345219008961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219008962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219008963 homodimer interface [polypeptide binding]; other site 345219008964 catalytic residue [active] 345219008965 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 345219008966 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 345219008967 putative dimer interface [polypeptide binding]; other site 345219008968 putative anticodon binding site; other site 345219008969 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 345219008970 homodimer interface [polypeptide binding]; other site 345219008971 motif 1; other site 345219008972 motif 2; other site 345219008973 active site 345219008974 motif 3; other site 345219008975 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 345219008976 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 345219008977 putative active site [active] 345219008978 putative NTP binding site [chemical binding]; other site 345219008979 putative nucleic acid binding site [nucleotide binding]; other site 345219008980 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 345219008981 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 345219008982 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 345219008983 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 345219008984 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 345219008985 minor groove reading motif; other site 345219008986 helix-hairpin-helix signature motif; other site 345219008987 substrate binding pocket [chemical binding]; other site 345219008988 active site 345219008989 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 345219008990 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 345219008991 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 345219008992 putative active site [active] 345219008993 putative NTP binding site [chemical binding]; other site 345219008994 putative nucleic acid binding site [nucleotide binding]; other site 345219008995 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 345219008996 Transglycosylase; Region: Transgly; pfam00912 345219008997 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 345219008998 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 345219008999 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 345219009000 Bacterial domain of unknown function (DUF1798); Region: DUF1798; pfam08807 345219009001 YppG-like protein; Region: YppG; pfam14179 345219009002 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 345219009003 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 345219009004 putative dimer interface [polypeptide binding]; other site 345219009005 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 345219009006 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 345219009007 ATP binding site [chemical binding]; other site 345219009008 putative Mg++ binding site [ion binding]; other site 345219009009 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 345219009010 nucleotide binding region [chemical binding]; other site 345219009011 ATP-binding site [chemical binding]; other site 345219009012 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 345219009013 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 345219009014 RNase_H superfamily; Region: RNase_H_2; pfam13482 345219009015 active site 345219009016 catalytic site [active] 345219009017 substrate binding site [chemical binding]; other site 345219009018 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 345219009019 hypothetical protein; Provisional; Region: PRK13660 345219009020 cell division protein GpsB; Provisional; Region: PRK14127 345219009021 DivIVA domain; Region: DivI1A_domain; TIGR03544 345219009022 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 345219009023 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 345219009024 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 345219009025 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 345219009026 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 345219009027 active site 345219009028 Zn binding site [ion binding]; other site 345219009029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 345219009030 active site 345219009031 xanthine permease; Region: pbuX; TIGR03173 345219009032 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 345219009033 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 345219009034 Archaea-specific RecJ-like exonuclease, contains DnaJ-type Zn finger domain [DNA replication, recombination, and repair]; Region: COG1107 345219009035 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 345219009036 Dynamin family; Region: Dynamin_N; pfam00350 345219009037 G1 box; other site 345219009038 GTP/Mg2+ binding site [chemical binding]; other site 345219009039 G2 box; other site 345219009040 Switch I region; other site 345219009041 G3 box; other site 345219009042 Switch II region; other site 345219009043 G4 box; other site 345219009044 G5 box; other site 345219009045 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 345219009046 Dynamin family; Region: Dynamin_N; pfam00350 345219009047 G1 box; other site 345219009048 GTP/Mg2+ binding site [chemical binding]; other site 345219009049 G2 box; other site 345219009050 Switch I region; other site 345219009051 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 345219009052 G3 box; other site 345219009053 Switch II region; other site 345219009054 GTP/Mg2+ binding site [chemical binding]; other site 345219009055 G4 box; other site 345219009056 G5 box; other site 345219009057 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 345219009058 DNA binding residues [nucleotide binding] 345219009059 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 345219009060 putative dimer interface [polypeptide binding]; other site 345219009061 glutamine synthetase, type I; Region: GlnA; TIGR00653 345219009062 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 345219009063 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 345219009064 LexA repressor; Validated; Region: PRK00215 345219009065 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219009066 putative Zn2+ binding site [ion binding]; other site 345219009067 putative DNA binding site [nucleotide binding]; other site 345219009068 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 345219009069 Catalytic site [active] 345219009070 cell division suppressor protein YneA; Provisional; Region: PRK14125 345219009071 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219009072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 345219009073 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 345219009074 catalytic residues [active] 345219009075 catalytic nucleophile [active] 345219009076 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 345219009077 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 345219009078 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 345219009079 TPP-binding site [chemical binding]; other site 345219009080 dimer interface [polypeptide binding]; other site 345219009081 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 345219009082 PYR/PP interface [polypeptide binding]; other site 345219009083 dimer interface [polypeptide binding]; other site 345219009084 TPP binding site [chemical binding]; other site 345219009085 Protein of unknown function (DUF2522); Region: DUF2522; pfam10747 345219009086 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 345219009087 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 345219009088 Response regulator receiver domain; Region: Response_reg; pfam00072 345219009089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219009090 active site 345219009091 phosphorylation site [posttranslational modification] 345219009092 intermolecular recognition site; other site 345219009093 dimerization interface [polypeptide binding]; other site 345219009094 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 345219009095 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 345219009096 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 345219009097 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 345219009098 putative acyl-acceptor binding pocket; other site 345219009099 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 345219009100 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 345219009101 dimer interface [polypeptide binding]; other site 345219009102 catalytic triad [active] 345219009103 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 345219009104 DNA-binding site [nucleotide binding]; DNA binding site 345219009105 RNA-binding motif; other site 345219009106 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 345219009107 dimanganese center [ion binding]; other site 345219009108 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 345219009109 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 345219009110 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 345219009111 heterotetramer interface [polypeptide binding]; other site 345219009112 active site pocket [active] 345219009113 cleavage site 345219009114 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 345219009115 nucleotide binding site [chemical binding]; other site 345219009116 N-acetyl-L-glutamate binding site [chemical binding]; other site 345219009117 acetylornithine aminotransferase; Provisional; Region: PRK02627 345219009118 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219009119 inhibitor-cofactor binding pocket; inhibition site 345219009120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219009121 catalytic residue [active] 345219009122 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12838 345219009123 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 345219009124 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 345219009125 catalytic site [active] 345219009126 subunit interface [polypeptide binding]; other site 345219009127 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 345219009128 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219009129 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 345219009130 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 345219009131 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 345219009132 ATP-grasp domain; Region: ATP-grasp_4; cl17255 345219009133 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 345219009134 substrate binding site [chemical binding]; other site 345219009135 ornithine carbamoyltransferase; Provisional; Region: PRK00779 345219009136 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 345219009137 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 345219009138 argininosuccinate synthase; Provisional; Region: PRK13820 345219009139 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 345219009140 ANP binding site [chemical binding]; other site 345219009141 Substrate Binding Site II [chemical binding]; other site 345219009142 Substrate Binding Site I [chemical binding]; other site 345219009143 argininosuccinate lyase; Provisional; Region: PRK00855 345219009144 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 345219009145 active sites [active] 345219009146 tetramer interface [polypeptide binding]; other site 345219009147 aspartate aminotransferase; Provisional; Region: PRK07681 345219009148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 345219009149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219009150 homodimer interface [polypeptide binding]; other site 345219009151 catalytic residue [active] 345219009152 FeoA domain; Region: FeoA; pfam04023 345219009153 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 345219009154 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 345219009155 G1 box; other site 345219009156 GTP/Mg2+ binding site [chemical binding]; other site 345219009157 Switch I region; other site 345219009158 G2 box; other site 345219009159 G3 box; other site 345219009160 Switch II region; other site 345219009161 G4 box; other site 345219009162 G5 box; other site 345219009163 Nucleoside recognition; Region: Gate; pfam07670 345219009164 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 345219009165 Nucleoside recognition; Region: Gate; pfam07670 345219009166 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 345219009167 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 345219009168 active site 345219009169 catalytic residues [active] 345219009170 metal binding site [ion binding]; metal-binding site 345219009171 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 345219009172 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 345219009173 DNA binding residues [nucleotide binding] 345219009174 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 345219009175 putative active site [active] 345219009176 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 345219009177 tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219009178 active site 345219009179 dimer interface [polypeptide binding]; other site 345219009180 DHH family; Region: DHH; pfam01368 345219009181 DHHA1 domain; Region: DHHA1; pfam02272 345219009182 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 345219009183 Uncharacterized conserved protein [Function unknown]; Region: COG2427 345219009184 gamma-glutamyl kinase; Provisional; Region: PRK05429 345219009185 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 345219009186 nucleotide binding site [chemical binding]; other site 345219009187 homotetrameric interface [polypeptide binding]; other site 345219009188 putative phosphate binding site [ion binding]; other site 345219009189 putative allosteric binding site; other site 345219009190 PUA domain; Region: PUA; pfam01472 345219009191 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 345219009192 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 345219009193 putative catalytic cysteine [active] 345219009194 Predicted permease; Region: DUF318; cl17795 345219009195 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 345219009196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 345219009197 active site 345219009198 metal binding site [ion binding]; metal-binding site 345219009199 selenophosphate synthetase; Provisional; Region: PRK00943 345219009200 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 345219009201 dimerization interface [polypeptide binding]; other site 345219009202 putative ATP binding site [chemical binding]; other site 345219009203 tRNA 2-selenouridine synthase; Region: tRNA_sel_U_synt; TIGR03167 345219009204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 345219009205 active site residue [active] 345219009206 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 345219009207 FAD binding domain; Region: FAD_binding_4; pfam01565 345219009208 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 345219009209 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219009210 NAD(P) binding site [chemical binding]; other site 345219009211 active site 345219009212 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 345219009213 active site 345219009214 catalytic site [active] 345219009215 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 345219009216 active site 2 [active] 345219009217 active site 1 [active] 345219009218 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 345219009219 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 345219009220 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 345219009221 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 345219009222 Protein of unknown function (DUF1189); Region: DUF1189; pfam06691 345219009223 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 345219009224 FAD binding domain; Region: FAD_binding_4; pfam01565 345219009225 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 345219009226 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 345219009227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219009228 Walker A/P-loop; other site 345219009229 ATP binding site [chemical binding]; other site 345219009230 Q-loop/lid; other site 345219009231 ABC transporter signature motif; other site 345219009232 Walker B; other site 345219009233 D-loop; other site 345219009234 H-loop/switch region; other site 345219009235 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 345219009236 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 345219009237 VanZ like family; Region: VanZ; cl01971 345219009238 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 345219009239 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 345219009240 dimerization interface [polypeptide binding]; other site 345219009241 DPS ferroxidase diiron center [ion binding]; other site 345219009242 ion pore; other site 345219009243 manganese transport protein MntH; Reviewed; Region: PRK00701 345219009244 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 345219009245 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 345219009246 putative active site [active] 345219009247 putative CoA binding site [chemical binding]; other site 345219009248 nudix motif; other site 345219009249 metal binding site [ion binding]; metal-binding site 345219009250 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 345219009251 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219009252 Coenzyme A binding pocket [chemical binding]; other site 345219009253 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 345219009254 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 345219009255 YpzG-like protein; Region: YpzG; pfam14139 345219009256 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 345219009257 glycogen branching enzyme; Provisional; Region: PRK12313 345219009258 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 345219009259 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 345219009260 active site 345219009261 catalytic site [active] 345219009262 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 345219009263 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 345219009264 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 345219009265 ligand binding site; other site 345219009266 oligomer interface; other site 345219009267 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 345219009268 dimer interface [polypeptide binding]; other site 345219009269 N-terminal domain interface [polypeptide binding]; other site 345219009270 sulfate 1 binding site; other site 345219009271 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 345219009272 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 345219009273 ligand binding site; other site 345219009274 oligomer interface; other site 345219009275 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 345219009276 dimer interface [polypeptide binding]; other site 345219009277 N-terminal domain interface [polypeptide binding]; other site 345219009278 sulfate 1 binding site; other site 345219009279 glycogen synthase; Provisional; Region: glgA; PRK00654 345219009280 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 345219009281 ADP-binding pocket [chemical binding]; other site 345219009282 homodimer interface [polypeptide binding]; other site 345219009283 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 345219009284 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 345219009285 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 345219009286 active site 345219009287 putative catalytic site [active] 345219009288 DNA binding site [nucleotide binding] 345219009289 putative phosphate binding site [ion binding]; other site 345219009290 metal binding site A [ion binding]; metal-binding site 345219009291 AP binding site [nucleotide binding]; other site 345219009292 metal binding site B [ion binding]; metal-binding site 345219009293 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 345219009294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219009296 putative substrate translocation pore; other site 345219009297 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 345219009298 classical (c) SDRs; Region: SDR_c; cd05233 345219009299 NAD(P) binding site [chemical binding]; other site 345219009300 active site 345219009301 A subgroup of L-lactate dehydrogenases; Region: LDH_3; cd05290 345219009302 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 345219009303 NAD binding site [chemical binding]; other site 345219009304 dimer interface [polypeptide binding]; other site 345219009305 tetramer (dimer of dimers) interface [polypeptide binding]; other site 345219009306 substrate binding site [chemical binding]; other site 345219009307 YceG-like family; Region: YceG; pfam02618 345219009308 Predicted membrane protein [Function unknown]; Region: COG2322 345219009309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 345219009310 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 345219009311 active site 345219009312 motif I; other site 345219009313 motif II; other site 345219009314 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 345219009315 Replication terminator protein; Region: RTP; pfam02334 345219009316 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 345219009317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 345219009318 acyl-activating enzyme (AAE) consensus motif; other site 345219009319 AMP binding site [chemical binding]; other site 345219009320 active site 345219009321 CoA binding site [chemical binding]; other site 345219009322 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 345219009323 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 345219009324 dimer interface [polypeptide binding]; other site 345219009325 active site 345219009326 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 345219009327 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 345219009328 NAD binding site [chemical binding]; other site 345219009329 homodimer interface [polypeptide binding]; other site 345219009330 homotetramer interface [polypeptide binding]; other site 345219009331 active site 345219009332 Small acid-soluble spore protein H family; Region: SspH; pfam08141 345219009333 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 345219009334 putative ADP-ribose binding site [chemical binding]; other site 345219009335 putative active site [active] 345219009336 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 345219009337 active site 345219009338 diiron metal binding site [ion binding]; other site 345219009339 SCP-2 sterol transfer family; Region: SCP2; pfam02036 345219009340 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 345219009341 Mechanosensitive ion channel; Region: MS_channel; pfam00924 345219009342 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 345219009343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219009344 Walker A motif; other site 345219009345 ATP binding site [chemical binding]; other site 345219009346 Walker B motif; other site 345219009347 arginine finger; other site 345219009348 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 345219009349 dihydrolipoamide dehydrogenase; Validated; Region: acoL; PRK06912 345219009350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 345219009351 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219009352 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 345219009353 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 345219009354 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 345219009355 E3 interaction surface; other site 345219009356 lipoyl attachment site [posttranslational modification]; other site 345219009357 e3 binding domain; Region: E3_binding; pfam02817 345219009358 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 345219009359 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 345219009360 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 345219009361 alpha subunit interface [polypeptide binding]; other site 345219009362 TPP binding site [chemical binding]; other site 345219009363 heterodimer interface [polypeptide binding]; other site 345219009364 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 345219009365 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 345219009366 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 345219009367 tetramer interface [polypeptide binding]; other site 345219009368 TPP-binding site [chemical binding]; other site 345219009369 heterodimer interface [polypeptide binding]; other site 345219009370 phosphorylation loop region [posttranslational modification] 345219009371 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 345219009372 hypothetical protein; Provisional; Region: PRK08201 345219009373 metal binding site [ion binding]; metal-binding site 345219009374 putative dimer interface [polypeptide binding]; other site 345219009375 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 345219009376 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 345219009377 DNA binding residues [nucleotide binding] 345219009378 dimer interface [polypeptide binding]; other site 345219009379 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 345219009380 sulfite reductase subunit beta; Provisional; Region: PRK13504 345219009381 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 345219009382 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 345219009383 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 345219009384 Flavodoxin; Region: Flavodoxin_1; pfam00258 345219009385 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 345219009386 FAD binding pocket [chemical binding]; other site 345219009387 FAD binding motif [chemical binding]; other site 345219009388 catalytic residues [active] 345219009389 NAD binding pocket [chemical binding]; other site 345219009390 phosphate binding motif [ion binding]; other site 345219009391 beta-alpha-beta structure motif; other site 345219009392 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 345219009393 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 345219009394 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 345219009395 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 345219009396 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 345219009397 active site 345219009398 metal binding site [ion binding]; metal-binding site 345219009399 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 345219009400 NMT1/THI5 like; Region: NMT1; pfam09084 345219009401 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 345219009402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 345219009403 dimer interface [polypeptide binding]; other site 345219009404 conserved gate region; other site 345219009405 putative PBP binding loops; other site 345219009406 ABC-ATPase subunit interface; other site 345219009407 H+ Antiporter protein; Region: 2A0121; TIGR00900 345219009408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009409 putative substrate translocation pore; other site 345219009410 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 345219009411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 345219009412 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219009413 Coenzyme A binding pocket [chemical binding]; other site 345219009414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 345219009415 MOSC domain; Region: MOSC; pfam03473 345219009416 3-alpha domain; Region: 3-alpha; pfam03475 345219009417 YkyB-like protein; Region: YkyB; pfam14177 345219009418 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 345219009419 thiamine phosphate binding site [chemical binding]; other site 345219009420 active site 345219009421 pyrophosphate binding site [ion binding]; other site 345219009422 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 345219009423 dimer interface [polypeptide binding]; other site 345219009424 substrate binding site [chemical binding]; other site 345219009425 ATP binding site [chemical binding]; other site 345219009426 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 345219009427 substrate binding site [chemical binding]; other site 345219009428 multimerization interface [polypeptide binding]; other site 345219009429 ATP binding site [chemical binding]; other site 345219009430 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 345219009431 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 345219009432 NAD(P) binding site [chemical binding]; other site 345219009433 active site 345219009434 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 345219009435 dimer interface [polypeptide binding]; other site 345219009436 substrate binding site [chemical binding]; other site 345219009437 ATP binding site [chemical binding]; other site 345219009438 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 345219009439 Na binding site [ion binding]; other site 345219009440 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 345219009441 nudix motif; other site 345219009442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219009443 Coenzyme A binding pocket [chemical binding]; other site 345219009444 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 345219009445 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 345219009446 Coenzyme A binding pocket [chemical binding]; other site 345219009447 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 345219009448 Antitoxin SpoIISB, type II toxin-antitoxin system; Region: SpoIISB_antitox; pfam14185 345219009449 Methyltransferase domain; Region: Methyltransf_31; pfam13847 345219009450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219009451 S-adenosylmethionine binding site [chemical binding]; other site 345219009452 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 345219009453 tartrate dehydrogenase; Region: TTC; TIGR02089 345219009454 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 345219009455 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 345219009456 Catalytic site [active] 345219009457 short chain dehydrogenase; Provisional; Region: PRK08309 345219009458 Nitronate monooxygenase; Region: NMO; pfam03060 345219009459 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 345219009460 FMN binding site [chemical binding]; other site 345219009461 substrate binding site [chemical binding]; other site 345219009462 putative catalytic residue [active] 345219009463 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 345219009464 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 345219009465 dimer interface [polypeptide binding]; other site 345219009466 putative metal binding site [ion binding]; other site 345219009467 pyruvate phosphate dikinase; Provisional; Region: PRK09279 345219009468 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 345219009469 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 345219009470 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 345219009471 PEP synthetase regulatory protein; Provisional; Region: PRK05339 345219009472 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219009473 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009474 putative substrate translocation pore; other site 345219009475 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 345219009476 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 345219009477 CAP-like domain; other site 345219009478 active site 345219009479 primary dimer interface [polypeptide binding]; other site 345219009480 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219009481 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219009482 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 345219009483 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 345219009484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219009485 ATP binding site [chemical binding]; other site 345219009486 Mg2+ binding site [ion binding]; other site 345219009487 G-X-G motif; other site 345219009488 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 345219009489 anchoring element; other site 345219009490 dimer interface [polypeptide binding]; other site 345219009491 ATP binding site [chemical binding]; other site 345219009492 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 345219009493 active site 345219009494 putative metal-binding site [ion binding]; other site 345219009495 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 345219009496 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 345219009497 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 345219009498 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 345219009499 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 345219009500 active site 345219009501 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 345219009502 acid-soluble spore protein N; Provisional; Region: sspN; PRK09398 345219009503 Protein of unknown function (DUF3901); Region: DUF3901; pfam13040 345219009504 aconitate hydratase; Validated; Region: PRK09277 345219009505 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 345219009506 substrate binding site [chemical binding]; other site 345219009507 ligand binding site [chemical binding]; other site 345219009508 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 345219009509 substrate binding site [chemical binding]; other site 345219009510 acid-soluble spore protein O; Provisional; Region: sspO; PRK02984 345219009511 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 345219009512 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 345219009513 tyrosine kinase; Provisional; Region: PRK11519 345219009514 acid-soluble spore protein P; Provisional; Region: sspP; PRK09399 345219009515 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 345219009516 N-acetyl-D-glucosamine binding site [chemical binding]; other site 345219009517 catalytic residue [active] 345219009518 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 345219009519 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 345219009520 dimer interface [polypeptide binding]; other site 345219009521 acyl-activating enzyme (AAE) consensus motif; other site 345219009522 putative active site [active] 345219009523 AMP binding site [chemical binding]; other site 345219009524 putative CoA binding site [chemical binding]; other site 345219009525 LrgB-like family; Region: LrgB; pfam04172 345219009526 LrgA family; Region: LrgA; cl00608 345219009527 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 345219009528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 345219009529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219009530 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 345219009531 Walker A/P-loop; other site 345219009532 ATP binding site [chemical binding]; other site 345219009533 Q-loop/lid; other site 345219009534 ABC transporter signature motif; other site 345219009535 Walker B; other site 345219009536 D-loop; other site 345219009537 H-loop/switch region; other site 345219009538 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 345219009539 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 345219009540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219009541 Walker A/P-loop; other site 345219009542 ATP binding site [chemical binding]; other site 345219009543 Q-loop/lid; other site 345219009544 ABC transporter signature motif; other site 345219009545 Walker B; other site 345219009546 D-loop; other site 345219009547 H-loop/switch region; other site 345219009548 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 345219009549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219009551 putative substrate translocation pore; other site 345219009552 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 345219009553 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 345219009554 putative transport protein YifK; Provisional; Region: PRK10746 345219009555 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 345219009556 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 345219009557 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 345219009558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009559 putative substrate translocation pore; other site 345219009560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 345219009561 dimerization interface [polypeptide binding]; other site 345219009562 putative DNA binding site [nucleotide binding]; other site 345219009563 putative Zn2+ binding site [ion binding]; other site 345219009564 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 345219009565 Protein of unknown function (DUF1672); Region: DUF1672; pfam07901 345219009566 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219009567 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219009568 active site 345219009569 phosphorylation site [posttranslational modification] 345219009570 intermolecular recognition site; other site 345219009571 dimerization interface [polypeptide binding]; other site 345219009572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219009573 DNA binding site [nucleotide binding] 345219009574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219009575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 345219009576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219009577 ATP binding site [chemical binding]; other site 345219009578 Mg2+ binding site [ion binding]; other site 345219009579 G-X-G motif; other site 345219009580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 345219009581 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 345219009582 Walker A/P-loop; other site 345219009583 ATP binding site [chemical binding]; other site 345219009584 Q-loop/lid; other site 345219009585 ABC transporter signature motif; other site 345219009586 Walker B; other site 345219009587 D-loop; other site 345219009588 H-loop/switch region; other site 345219009589 FtsX-like permease family; Region: FtsX; pfam02687 345219009590 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 345219009591 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 345219009592 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 345219009593 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 345219009594 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 345219009595 GTP cyclohydrolase I; Provisional; Region: PLN03044 345219009596 active site 345219009597 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 345219009598 DNA-binding site [nucleotide binding]; DNA binding site 345219009599 RNA-binding motif; other site 345219009600 methionine sulfoxide reductase A; Provisional; Region: PRK14054 345219009601 Uncharacterized conserved protein [Function unknown]; Region: COG3937 345219009602 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 345219009603 ABC1 family; Region: ABC1; pfam03109 345219009604 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 345219009605 active site 345219009606 ATP binding site [chemical binding]; other site 345219009607 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 345219009608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009609 putative substrate translocation pore; other site 345219009610 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 345219009611 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 345219009612 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 345219009613 TrkA-N domain; Region: TrkA_N; pfam02254 345219009614 TrkA-C domain; Region: TrkA_C; pfam02080 345219009615 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 345219009616 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 345219009617 Predicted permeases [General function prediction only]; Region: RarD; COG2962 345219009618 EamA-like transporter family; Region: EamA; pfam00892 345219009619 putative inner membrane protein; Provisional; Region: PRK11099 345219009620 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 345219009621 CPxP motif; other site 345219009622 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 345219009623 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 345219009624 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 345219009625 metal binding site [ion binding]; metal-binding site 345219009626 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 345219009627 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 345219009628 substrate binding site [chemical binding]; other site 345219009629 glutamase interaction surface [polypeptide binding]; other site 345219009630 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 345219009631 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 345219009632 catalytic residues [active] 345219009633 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 345219009634 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 345219009635 putative active site [active] 345219009636 oxyanion strand; other site 345219009637 catalytic triad [active] 345219009638 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 345219009639 putative active site pocket [active] 345219009640 4-fold oligomerization interface [polypeptide binding]; other site 345219009641 metal binding residues [ion binding]; metal-binding site 345219009642 3-fold/trimer interface [polypeptide binding]; other site 345219009643 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 345219009644 histidinol dehydrogenase; Region: hisD; TIGR00069 345219009645 NAD binding site [chemical binding]; other site 345219009646 dimerization interface [polypeptide binding]; other site 345219009647 product binding site; other site 345219009648 substrate binding site [chemical binding]; other site 345219009649 zinc binding site [ion binding]; other site 345219009650 catalytic residues [active] 345219009651 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 345219009652 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 345219009653 Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393 345219009654 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 345219009655 dimer interface [polypeptide binding]; other site 345219009656 motif 1; other site 345219009657 active site 345219009658 motif 2; other site 345219009659 motif 3; other site 345219009660 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 345219009661 CHY zinc finger; Region: zf-CHY; pfam05495 345219009662 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 345219009663 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 345219009664 Cl binding site [ion binding]; other site 345219009665 oligomer interface [polypeptide binding]; other site 345219009666 LysE type translocator; Region: LysE; pfam01810 345219009667 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 345219009668 Spore germination protein; Region: Spore_permease; cl17796 345219009669 DNA topoisomerase III; Provisional; Region: PRK07726 345219009670 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 345219009671 active site 345219009672 putative interdomain interaction site [polypeptide binding]; other site 345219009673 putative metal-binding site [ion binding]; other site 345219009674 putative nucleotide binding site [chemical binding]; other site 345219009675 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 345219009676 domain I; other site 345219009677 DNA binding groove [nucleotide binding] 345219009678 phosphate binding site [ion binding]; other site 345219009679 domain II; other site 345219009680 domain III; other site 345219009681 nucleotide binding site [chemical binding]; other site 345219009682 catalytic site [active] 345219009683 domain IV; other site 345219009684 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 345219009685 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219009686 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 345219009687 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 345219009688 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 345219009689 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 345219009690 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 345219009691 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 345219009692 [2Fe-2S] cluster binding site [ion binding]; other site 345219009693 FOG: CBS domain [General function prediction only]; Region: COG0517 345219009694 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 345219009695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 345219009696 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 345219009697 Uncharacterized conserved protein [Function unknown]; Region: COG2135 345219009698 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 345219009699 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 345219009700 active site residue [active] 345219009701 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 345219009702 DNA topoisomerase III; Provisional; Region: PRK07726 345219009703 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 345219009704 active site 345219009705 putative interdomain interaction site [polypeptide binding]; other site 345219009706 putative metal-binding site [ion binding]; other site 345219009707 putative nucleotide binding site [chemical binding]; other site 345219009708 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 345219009709 domain I; other site 345219009710 DNA binding groove [nucleotide binding] 345219009711 phosphate binding site [ion binding]; other site 345219009712 domain II; other site 345219009713 domain III; other site 345219009714 nucleotide binding site [chemical binding]; other site 345219009715 catalytic site [active] 345219009716 domain IV; other site 345219009717 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 345219009718 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219009719 Uncharacterized conserved protein [Function unknown]; Region: COG1284 345219009720 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 345219009721 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 345219009722 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 345219009723 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 345219009724 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 345219009725 NAD(P) binding site [chemical binding]; other site 345219009726 catalytic residues [active] 345219009727 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 345219009728 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 345219009729 E3 interaction surface; other site 345219009730 lipoyl attachment site [posttranslational modification]; other site 345219009731 e3 binding domain; Region: E3_binding; pfam02817 345219009732 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 345219009733 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 345219009734 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 345219009735 TPP-binding site [chemical binding]; other site 345219009736 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 345219009737 dimer interface [polypeptide binding]; other site 345219009738 PYR/PP interface [polypeptide binding]; other site 345219009739 TPP binding site [chemical binding]; other site 345219009740 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 345219009741 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 345219009742 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 345219009743 dimerization interface [polypeptide binding]; other site 345219009744 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 345219009745 dimer interface [polypeptide binding]; other site 345219009746 phosphorylation site [posttranslational modification] 345219009747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219009748 ATP binding site [chemical binding]; other site 345219009749 Mg2+ binding site [ion binding]; other site 345219009750 G-X-G motif; other site 345219009751 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 345219009752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 345219009753 active site 345219009754 phosphorylation site [posttranslational modification] 345219009755 intermolecular recognition site; other site 345219009756 dimerization interface [polypeptide binding]; other site 345219009757 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 345219009758 DNA binding site [nucleotide binding] 345219009759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 345219009760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 345219009761 putative substrate translocation pore; other site 345219009762 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 345219009763 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 345219009764 catalytic residues [active] 345219009765 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 345219009766 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 345219009767 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 345219009768 active site 345219009769 Predicted transcriptional regulators [Transcription]; Region: COG1695 345219009770 Transcriptional regulator PadR-like family; Region: PadR; cl17335 345219009771 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 345219009772 Sulfatase; Region: Sulfatase; pfam00884 345219009773 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 345219009774 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 345219009775 active site 345219009776 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 345219009777 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 345219009778 putative DNA binding site [nucleotide binding]; other site 345219009779 putative homodimer interface [polypeptide binding]; other site 345219009780 ATP-dependent DNA ligase; Reviewed; Region: ligD; PRK09633 345219009781 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 345219009782 active site 345219009783 DNA binding site [nucleotide binding] 345219009784 LigD_Pol_like_3: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 3. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_3; cd04866 345219009785 nucleotide binding site [chemical binding]; other site 345219009786 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 345219009787 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 345219009788 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 345219009789 multidrug efflux protein; Reviewed; Region: PRK01766 345219009790 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 345219009791 cation binding site [ion binding]; other site 345219009792 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 345219009793 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 345219009794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 345219009795 MarR family; Region: MarR_2; cl17246 345219009796 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 345219009797 C-terminal peptidase (prc); Region: prc; TIGR00225 345219009798 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 345219009799 protein binding site [polypeptide binding]; other site 345219009800 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 345219009801 Catalytic dyad [active] 345219009802 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 345219009803 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 345219009804 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 345219009805 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 345219009806 YozD-like protein; Region: YozD; pfam14162 345219009807 hypothetical protein; Provisional; Region: PRK13672 345219009808 CHASE3 domain; Region: CHASE3; pfam05227 345219009809 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 345219009810 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 345219009811 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 345219009812 dimer interface [polypeptide binding]; other site 345219009813 putative CheW interface [polypeptide binding]; other site 345219009814 methionine sulfoxide reductase B; Provisional; Region: PRK00222 345219009815 SelR domain; Region: SelR; pfam01641 345219009816 methionine sulfoxide reductase A; Provisional; Region: PRK14054 345219009817 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 345219009818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 345219009819 S-adenosylmethionine binding site [chemical binding]; other site 345219009820 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 345219009821 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 345219009822 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 345219009823 active site 345219009824 catalytic triad [active] 345219009825 oxyanion hole [active] 345219009826 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 345219009827 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 345219009828 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 345219009829 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 345219009830 folate binding site [chemical binding]; other site 345219009831 NADP+ binding site [chemical binding]; other site 345219009832 thymidylate synthase; Reviewed; Region: thyA; PRK01827 345219009833 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 345219009834 dimerization interface [polypeptide binding]; other site 345219009835 active site 345219009836 YpjP-like protein; Region: YpjP; pfam14005 345219009837 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 345219009838 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 345219009839 Virulence factor; Region: Virulence_fact; pfam13769 345219009840 HEAT repeat; Region: HEAT; pfam02985 345219009841 HEAT repeats; Region: HEAT_2; pfam13646 345219009842 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 345219009843 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 345219009844 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 345219009845 Walker A/P-loop; other site 345219009846 ATP binding site [chemical binding]; other site 345219009847 Q-loop/lid; other site 345219009848 ABC transporter signature motif; other site 345219009849 Walker B; other site 345219009850 D-loop; other site 345219009851 H-loop/switch region; other site 345219009852 ABC transporter; Region: ABC_tran_2; pfam12848 345219009853 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 345219009854 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 345219009855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219009856 Zn2+ binding site [ion binding]; other site 345219009857 Mg2+ binding site [ion binding]; other site 345219009858 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 345219009859 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 345219009860 Potassium binding sites [ion binding]; other site 345219009861 Cesium cation binding sites [ion binding]; other site 345219009862 manganese transport transcriptional regulator; Provisional; Region: PRK03902 345219009863 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 345219009864 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 345219009865 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 345219009866 DNA-binding site [nucleotide binding]; DNA binding site 345219009867 RNA-binding motif; other site 345219009868 Protein of unknown function (DUF2602); Region: DUF2602; pfam10782 345219009869 small, acid-soluble spore protein L; Region: SASP_sspL; TIGR03093 345219009870 5'-3' exonuclease; Region: 53EXOc; smart00475 345219009871 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 345219009872 active site 345219009873 metal binding site 1 [ion binding]; metal-binding site 345219009874 putative 5' ssDNA interaction site; other site 345219009875 metal binding site 3; metal-binding site 345219009876 metal binding site 2 [ion binding]; metal-binding site 345219009877 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 345219009878 putative DNA binding site [nucleotide binding]; other site 345219009879 putative metal binding site [ion binding]; other site 345219009880 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 345219009881 Aluminium resistance protein; Region: Alum_res; pfam06838 345219009882 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 345219009883 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 345219009884 HflX GTPase family; Region: HflX; cd01878 345219009885 G1 box; other site 345219009886 GTP/Mg2+ binding site [chemical binding]; other site 345219009887 Switch I region; other site 345219009888 G2 box; other site 345219009889 G3 box; other site 345219009890 Switch II region; other site 345219009891 G4 box; other site 345219009892 G5 box; other site 345219009893 stage V sporulation protein K; Region: spore_V_K; TIGR02881 345219009894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219009895 Walker A motif; other site 345219009896 ATP binding site [chemical binding]; other site 345219009897 Walker B motif; other site 345219009898 arginine finger; other site 345219009899 bacterial Hfq-like; Region: Hfq; cd01716 345219009900 hexamer interface [polypeptide binding]; other site 345219009901 Sm1 motif; other site 345219009902 RNA binding site [nucleotide binding]; other site 345219009903 Sm2 motif; other site 345219009904 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 345219009905 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 345219009906 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 345219009907 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 345219009908 Excalibur calcium-binding domain; Region: Excalibur; cl05460 345219009909 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 345219009910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 345219009911 ATP binding site [chemical binding]; other site 345219009912 Mg2+ binding site [ion binding]; other site 345219009913 G-X-G motif; other site 345219009914 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 345219009915 ATP binding site [chemical binding]; other site 345219009916 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 345219009917 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 345219009918 MutS domain I; Region: MutS_I; pfam01624 345219009919 MutS domain II; Region: MutS_II; pfam05188 345219009920 MutS domain III; Region: MutS_III; pfam05192 345219009921 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 345219009922 Walker A/P-loop; other site 345219009923 ATP binding site [chemical binding]; other site 345219009924 Q-loop/lid; other site 345219009925 ABC transporter signature motif; other site 345219009926 Walker B; other site 345219009927 D-loop; other site 345219009928 H-loop/switch region; other site 345219009929 Outer spore coat protein E (CotE); Region: CotE; pfam10628 345219009930 Predicted membrane protein [Function unknown]; Region: COG4550 345219009931 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 345219009932 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 345219009933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 345219009934 FeS/SAM binding site; other site 345219009935 TRAM domain; Region: TRAM; pfam01938 345219009936 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 345219009937 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 345219009938 inhibitor-cofactor binding pocket; inhibition site 345219009939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 345219009940 catalytic residue [active] 345219009941 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 345219009942 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 345219009943 tetramerization interface [polypeptide binding]; other site 345219009944 NAD(P) binding site [chemical binding]; other site 345219009945 catalytic residues [active] 345219009946 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 345219009947 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 345219009948 putative active site [active] 345219009949 heme pocket [chemical binding]; other site 345219009950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 345219009951 Walker A motif; other site 345219009952 ATP binding site [chemical binding]; other site 345219009953 Walker B motif; other site 345219009954 arginine finger; other site 345219009955 amino acid transporter; Region: 2A0306; TIGR00909 345219009956 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 345219009957 Peptidase family U32; Region: Peptidase_U32; pfam01136 345219009958 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 345219009959 Peptidase family U32; Region: Peptidase_U32; pfam01136 345219009960 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 345219009961 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 345219009962 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 345219009963 putative active site [active] 345219009964 metal binding site [ion binding]; metal-binding site 345219009965 homodimer binding site [polypeptide binding]; other site 345219009966 phosphodiesterase; Provisional; Region: PRK12704 345219009967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 345219009968 Zn2+ binding site [ion binding]; other site 345219009969 Mg2+ binding site [ion binding]; other site 345219009970 recombinase A; Provisional; Region: recA; PRK09354 345219009971 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 345219009972 hexamer interface [polypeptide binding]; other site 345219009973 Walker A motif; other site 345219009974 ATP binding site [chemical binding]; other site 345219009975 Walker B motif; other site 345219009976 competence damage-inducible protein A; Provisional; Region: PRK00549 345219009977 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 345219009978 putative MPT binding site; other site 345219009979 Competence-damaged protein; Region: CinA; pfam02464 345219009980 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 345219009981 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 345219009982 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 345219009983 non-specific DNA binding site [nucleotide binding]; other site 345219009984 salt bridge; other site 345219009985 sequence-specific DNA binding site [nucleotide binding]; other site 345219009986 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 345219009987 ACT domain; Region: ACT; pfam01842 345219009988 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 345219009989 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 345219009990 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 345219009991 classical (c) SDRs; Region: SDR_c; cd05233 345219009992 NAD(P) binding site [chemical binding]; other site 345219009993 active site 345219009994 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 345219009995 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 345219009996 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 345219009997 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 345219009998 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 345219009999 Transposase; Region: DEDD_Tnp_IS110; pfam01548 345219010000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 345219010001 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 345219010002 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 345219010003 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 345219010004 TM-ABC transporter signature motif; other site 345219010005 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 345219010006 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 345219010007 TM-ABC transporter signature motif; other site 345219010008 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 345219010009 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 345219010010 Walker A/P-loop; other site 345219010011 ATP binding site [chemical binding]; other site 345219010012 Q-loop/lid; other site 345219010013 ABC transporter signature motif; other site 345219010014 Walker B; other site 345219010015 D-loop; other site 345219010016 H-loop/switch region; other site 345219010017 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 345219010018 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 345219010019 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 345219010020 ligand binding site [chemical binding]; other site 345219010021 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 345219010022 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 345219010023 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 345219010024 YlzJ-like protein; Region: YlzJ; pfam14035 345219010025 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 345219010026 Clp protease; Region: CLP_protease; pfam00574 345219010027 active site 345219010028 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 345219010029 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 345219010030 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 345219010031 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 345219010032 dihydrodipicolinate synthase; Region: dapA; TIGR00674 345219010033 dimer interface [polypeptide binding]; other site 345219010034 active site 345219010035 catalytic residue [active]